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356 results on '"Garmendia J"'

2. Lipid-based nanomedicines for the treatment of bacterial respiratory infections: current state and new perspectives

Author

Comunidad de Madrid, Ministerio de Ciencia e Innovación (España), Diputación Foral de Navarra, Instituto de Salud Carlos III, Ministerio de Ciencia, Innovación y Universidades (España), Arroyo-Urea, E. M., Lázaro-Díez, M., Garmendia, J., Herranz, Fernando, González-Paredes, Ana, Comunidad de Madrid, Ministerio de Ciencia e Innovación (España), Diputación Foral de Navarra, Instituto de Salud Carlos III, Ministerio de Ciencia, Innovación y Universidades (España), Arroyo-Urea, E. M., Lázaro-Díez, M., Garmendia, J., Herranz, Fernando, and González-Paredes, Ana

Abstract

The global threat posed by antimicrobial resistance demands urgent action and the development of effective drugs. Lower respiratory tract infections remain the deadliest communicable disease worldwide, often challenging to treat due to the presence of bacteria that form recalcitrant biofilms. There is consensus that novel anti-infectives with reduced resistance compared with conventional antibiotics are needed, leading to extensive research on innovative antibacterial agents. This review explores the recent progress in lipid-based nanomedicines developed to counteract bacterial respiratory infections, especially those involving biofilm growth; focuses on improved drug bioavailability and targeting and highlights novel strategies to enhance treatment efficacy while emphasizing the importance of continued research in this dynamic field.

Published
2024

7. Adapting a dynamic system model using life traits and local fishery knowledge — Application to a population of exploited marine bivalves (Ruditapes philippinarum) in a mesotidal coastal lagoon

Author

Caill-milly, Nathalie, Garmendia, J. Bald, D'Amico, Franck, Guyader, Olivier, Dang, C., Bru, N., Caill-milly, Nathalie, Garmendia, J. Bald, D'Amico, Franck, Guyader, Olivier, Dang, C., and Bru, N.

Abstract

Effective planning and management strategies of the Manila clam (Ruditapes philippinarum) stock in Arcachon Bay rely on a co-management approach, involving scientific advice and the fishing industry. In order to strengthen this management process, a specific compartmental single-species model has been developed to assess different management strategies. Based upon a size structure of the population and built from the dynamic systems paradigm, the modelling involves selected environmental and fishery-related parameters for their impact on the population dynamics. Integration of newly available life traits data regarding the local population and better knowledge of the fishing activity and its control parameters have enabled a revision of the existing version including model parameters and integration of new formulations. Effect of food availability and total suspended matter on the production of newly settled juveniles, natural mortality, growth rates, and price, accounted for the bulk of the undertaken improvements. Model performance was evaluated by comparing simulation outputs to observed data from stock assessments (2003, 2006, 2008, 2010, 2012, 2014 and 2018). In addition, a sensitivity analysis regarding uncertainty on parameters related to biological and environmental aspects was carried out to provide information about parameters that influence the outputs of the model the most. In particular, this highlighted that a deeper understanding of the processes related to the reproduction phase and its control parameters on biomass should be pursued. The improvements enable the calibration of the model with parameters that are as close as possible to the specificities of the stock considered. This adaptation permits use of the model to test various management strategies on the stock evolution and also to evaluate potential effects of environmental or market fluctuations. It encompasses ecological and socio-economic valuations of the measures of impact. As long as th

Published
2022
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8. Contribuciones al conocimiento de la flora del País Vasco (VIII)

Author

Aizpuru, I., Aperribay, J.A., Garin, I., Garmendia, J., Olariaga, I.

Subjects
Spermatophyta, Corológia, SO de Europa, País Vasco, Science
Abstract

Nueva entrega con datos de interés acerca de la distribución de 18 taxones de plantas raras en el País Vasco. A destacar el hallazgo de dos nuevas especies de árboles - Prunus padus L. y Ulmus laevis Pallas- para Gipuzkoa y la ampliación de área de Woodwardia radicans (L.) Sm. hasta Navarra

Published
2009

9. Viral detection and serological response critically ill patients with SARS-CoV-2. Implications for isolation withdrawal

Author

Garcia Garmendia, J. L., Ramirez Arcos, M., Barrero Almodovar, A. E., Chavez Caballero, M., Jorge Amigo, V., Serrano Martino, M. C., [Garcia Garmendia, J. L.] Hosp San Juan Dios Aljarafe, Serv Cuidados Crit & Urgencias, Unidad Cuidados Intens, Seville, Spain, [Barrero Almodovar, A. E.] Hosp San Juan Dios Aljarafe, Serv Cuidados Crit & Urgencias, Unidad Cuidados Intens, Seville, Spain, [Jorge Amigo, V.] Hosp San Juan Dios Aljarafe, Serv Cuidados Crit & Urgencias, Unidad Cuidados Intens, Seville, Spain, [Ramirez Arcos, M.] Hosp San Juan Dios Aljarafe, Serv Lab, Unidad Microbiol, Seville, Spain, [Chavez Caballero, M.] Hosp San Juan Dios Aljarafe, Serv Lab, Unidad Microbiol, Seville, Spain, and [Serrano Martino, M. C.] Hosp San Juan Dios Aljarafe, Serv Lab, Unidad Microbiol, Seville, Spain

Published
2020

10. ESICM LIVES 2016: part one: Milan, Italy. 1-5 October 2016

Author

Bos, L., Schouten, L., van Vught, L., Wiewel, M., Ong, D., Cremer, O., Artigas, A., Martin-Loeches, I., Hoogendijk, A., van der Poll, T., Horn, J., Juffermans, N., Schultz, M., de Prost, N., Pham, T., Carteaux, G., Dessap, A. Mekontso, Brun-Buisson, C., Fan, E., Bellani, G., Laffey, J., Mercat, A., Brochard, L., Maitre, B., Howells, P. A., Thickett, D. R., Knox, C., Park, D. P., Gao, F., Tucker, O., Whitehouse, T., McAuley, D. F., Perkins, G. D., Pham, T., Laffey, J., Bellani, G., Fan, E., Pisani, L., Roozeman, J. P., Simonis, F. D., Giangregorio, A., Schouten, L. R., Van der Hoeven, S. M., Horn, J., Neto, A. Serpa, Festic, E., Dondorp, A. M., Grasso, S., Bos, L. D., Schultz, M. J., Koster-Brouwer, M., Verboom, D., Scicluna, B., van de Groep, K., Frencken, J., Schultz, M., van der Poll, T., Bonten, M., Cremer, O., Ko, J. I., Kim, K. S., Suh, G. J., Kwon, W. Y., Kim, K., Shin, J. H., Ranzani, O. T., Prina, E., Menendez, R., Ceccato, A., Mendez, R., Cilloniz, C., Gabarrus, A., Ferrer, M., Torres, A., Urbano, A., Zhang, L. A., Swigon, D., Pike, F., Parker, R. S., Clermont, G., Scheer, C., Kuhn, S. O., Modler, A., Vollmer, M., Fuchs, C., Hahnenkamp, K., Rehberg, S., Gründling, M., Taggu, A., Darang, N., Öveges, N., László, I., Tánczos, K., Németh, M., Lebák, G., Tudor, B., Érces, D., Kaszaki, J., Huber, W., Trásy, D., Molnár, Z., Ferrara, G., Edul, V. S. Kanoore, Canales, H. S., Martins, E., Canullán, C., Murias, G., Pozo, M. O., Eguillor, J. F. Caminos, Buscetti, M. G., Ince, C., Dubin, A., Aya, H. D., Rhodes, A., Fletcher, N., Grounds, R. M., Cecconi, M., Jacquet-Lagrèze, M., Riche, M., Schweizer, R., Portran, P., Fornier, W., Lilot, M., Neidecker, J., Fellahi, J. L., Escoresca-Ortega, A., Gutiérrez-Pizarraya, A., Charris-Castro, L., Corcia-Palomo, Y., Fernandez-Delgado, E., Garnacho-Montero, J., Roger, C., Muller, L., Elotmani, L., Lipman, J., Lefrant, J. Y., Roberts, J. A., Muñoz-Bermúdez, R., Samper, M., Climent, C., Vasco, F., Sara, V., Luque, S., Campillo, N., Cerrato, S. Grau, Masclans, J. R., Alvarez-Lerma, F., Brugger, S. Carvalho, Jimenez, G. Jimenez, Torner, M. Miralbés, Cabello, J. Trujillano, Garrido, B. Balsera, Casals, X. Nuvials, Gaite, F. Barcenilla, Vidal, M. Vallverdú, Martínez, M. Palomar, Gusarov, V., Shilkin, D., Dementienko, M., Nesterova, E., Lashenkova, N., Kuzovlev, A., Zamyatin, M., Demoule, A., Carreira, S., Lavault, S., Palancca, O., Morawiec, E., Mayaux, J., Arnulf, I., Similowski, T., Rasmussen, B. S., Maltesen, R. G., Hanifa, M., Pedersen, S., Kristensen, S. R., Wimmer, R., Panigada, M., Bassi, G. Li, Ranzani, O. T., Kolobow, T., Zanella, A., Cressoni, M., Berra, L., Parrini, V., Kandil, H., Salati, G., Livigni, S., Amatu, A., Andreotti, A., Tagliaferri, F., Moise, G., Mercurio, G., Costa, A., Vezzani, A., Lindau, S., Babel, J., Cavana, M., Consonni, D., Pesenti, A., Gattinoni, L., Torres, A., Mansouri, P., Zand, F., Zahed, L., Dehghanrad, F., Bahrani, M., Ghorbani, M., Cambiaghi, B., Moerer, O., Mauri, T., Kunze-Szikszay, N., Ritter, C., Pesenti, A., Quintel, M., Vilander, L. M., Kaunisto, M. A., Vaara, S. T., Pettilä, V., Mulier, J. L. G. Haitsma, Rozemeijer, S., Spoelstra-de Man, A. M. E., Elbers, P. E., Tuinman, P. R., de Waard, M. C., Oudemans-van Straaten, H. M., Liberatore, A. M. A., Souza, R. B., Martins, A. M. C. R. P. F., Vieira, J. C. F., Koh, I. H. J., Martínez, M. Galindo, Sánchez, R. Jiménez, Gascón, L. Martínez, Mulero, M. D. Rodríguez, Freire, A. Ortín, Muñoz, A. Ojados, Acebes, S. Rebollo, Martínez, Á. Fernández, Aliaga, S. Moreno, Para, L. Herrera, Payá, J. Murcia, Mulero, F. Rodríguez, Guerci, P., Ince, Y., Heeman, P., Ergin, B., Ince, C., Uz, Z., Massey, M., Ince, Y., Papatella, R., Bulent, E., Guerci, P., Toraman, F., Ince, C., Longbottom, E. R., Torrance, H. D., Owen, H. C., Hinds, C. J., Pearse, R. M., O’Dywer, M. J., Trogrlic, Z., van der Jagt, M., Lingsma, H., Ponssen, H. H., Schoonderbeek, J. F., Schreiner, F., Verbrugge, S. J., Duran, S., van Achterberg, T., Bakker, J., Gommers, D. A. M. P. J., Ista, E., Krajčová, A., Waldauf, P., Duška, F., Shah, A., Roy, N., McKechnie, S., Doree, C., Fisher, S., Stanworth, S. J., Jensen, J. F., Overgaard, D., Bestle, M. H., Christensen, D. F., Egerod, I., Pivkina, A., Gusarov, V., Zhivotneva, I., Pasko, N., Zamyatin, M., Jensen, J. F., Egerod, I., Bestle, M. H., Christensen, D. F., Alklit, A., Hansen, R. L., Knudsen, H., Grode, L. B., Overgaard, D., Hravnak, M., Chen, L., Dubrawski, A., Clermont, G., Pinsky, M. R., Parry, S. M., Knight, L. D., Connolly, B. C., Baldwin, C. E., Puthucheary, Z. A., Denehy, L., Hart, N., Morris, P. E., Mortimore, J., Granger, C. L., Jensen, H. I., Piers, R., Van den Bulcke, B., Malmgren, J., Metaxa, V., Reyners, A. K., Darmon, M., Rusinova, K., Talmor, D., Meert, A. P., Cancelliere, L., Zubek, L., Maia, P., Michalsen, A., Decruyenaere, J., Kompanje, E., Vanheule, S., Azoulay, E., Vansteelandt, S., Benoit, D., Van den Bulcke, B., Piers, R., Jensen, H. I., Malmgren, J., Metaxa, V., Reyners, A. K., Darmon, M., Rusinova, K., Talmor, D., Meert, A. P., Cancelliere, L., Zubek, L., Maia, P., Michalsen, A., Decruyenaere, J., Kompanje, E., Vanheule, S., Azoulay, E., Vansteelandt, S., Benoit, D., Ryan, C., Dawson, D., Ball, J., Noone, K., Aisling, B., Prudden, S., Ntantana, A., Matamis, D., Savvidou, S., Giannakou, M., Gouva, M., Nakos, G., Koulouras, V., Aron, J., Lumley, G., Milliken, D., Dhadwal, K., McGrath, B. A., Lynch, S. J., Bovento, B., Sharpe, G., Grainger, E., Pieri-Davies, S., Wallace, S., McGrath, B., Lynch, S. J., Bovento, B., Grainger, E., Pieri-Davies, S., Sharpe, G., Wallace, S., Jung, M., Cho, J., Park, H., Suh, G., Kousha, O., Paddle, J., Gripenberg, L. Gamrin, Rehal, M. Sundström, Wernerman, J., Rooyackers, O., de Grooth, H. J., Choo, W. P., Spoelstra-de Man, A. M., Swart, E. L., Oudemans-van Straaten, H. M., Talan, L., Güven, G., Altıntas, N. D., Padar, M., Uusvel, G., Starkopf, L., Starkopf, J., Blaser, A. Reintam, Kalaiselvan, M. S., Arunkumar, A. S., Renuka, M. K., Shivkumar, R. L., Volbeda, M., ten Kate, D., Hoekstra, M., van der Maaten, J. M., Nijsten, M. W., Komaromi, A., Rooyackers, O., Wernerman, J., Norberg, Å., Smedberg, M., Mori, M., Pettersson, L., Norberg, Å., Rooyackers, O., Wernerman, J., Theodorakopoulou, M., Christodoulopoulou, T., Diamantakis, A., Frantzeskaki, F., Kontogiorgi, M., Chrysanthopoulou, E., Lygnos, M., Diakaki, C., Armaganidis, A., Gundogan, K., Dogan, E., Coskun, R., Muhtaroglu, S., Sungur, M., Ziegler, T., Guven, M., Kleyman, A., Khaliq, W., Andreas, D., Singer, M., Meierhans, R., Schuepbach, R., De Brito-Ashurst, I., Zand, F., Sabetian, G., Nikandish, R., Hagar, F., Masjedi, M., Maghsudi, B., Vazin, A., Ghorbani, M., Asadpour, E., Kao, K. C., Chiu, L. C., Hung, C. Y., Chang, C. H., Li, S. H., Hu, H. C., El Maraghi, S., Ali, M., Rageb, D., Helmy, M., Marin-Corral, J., Vilà, C., Masclans, J. R., Vàzquez, A., Martín-Loeches, I., Díaz, E., Yébenes, J. C., Rodriguez, A., Álvarez-Lerma, F., Varga, N., Cortina-Gutiérrez, A., Dono, L., Martínez-Martínez, M., Maldonado, C., Papiol, E., Pérez-Carrasco, M., Ferrer, R., Nweze, K., Morton, B., Welters, I., Houard, M., Voisin, B., Ledoux, G., Six, S., Jaillette, E., Nseir, S., Romdhani, S., Bouneb, R., Loghmari, D., Aicha, N. Ben, Ayachi, J., Meddeb, K., Chouchène, I., Khedher, A., Boussarsar, M., Chan, K. S., Yu, W. L., Marin-Corral, J., Vilà, C., Masclans, J. R., Nolla, J., Vidaur, L., Bonastre, J., Suberbiola, B., Guerrero, J. E., Rodriguez, A., Coll, N. Ramon, Jiménez, G. Jiménez, Brugger, S. Carvalho, Calero, J. Codina, Garrido, B. Balsera, García, M., Martínez, M. Palomar, Vidal, M. Vallverdú, de la Torre, M. C., Vendrell, E., Palomera, E., Güell, E., Yébenes, J. C., Serra-Prat, M., Bermejo-Martín, J. F., Almirall, J., Tomas, E., Escoval, A., Froe, F., Pereira, M. H. Vitoria, Velez, N., Viegas, E., Filipe, E., Groves, C., Reay, M., Chiu, L. C., Hu, H. C., Hung, C. Y., Chang, C. H., Li, S. H., Kao, K. C., Ballin, A., Facchin, F., Sartori, G., Zarantonello, F., Campello, E., Radu, C. M., Rossi, S., Ori, C., Simioni, P., Umei, N., Shingo, I., Santos, A. C., Candeias, C., Moniz, I., Marçal, R., e Silva, Z. Costa, Ribeiro, J. M., Georger, J. F., Ponthus, J. P., Tchir, M., Amilien, V., Ayoub, M., Barsam, E., Martucci, G., Panarello, G., Tuzzolino, F., Capitanio, G., Ferrazza, V., Carollo, T., Giovanni, L., Arcadipane, A., Sánchez, M. López, González-Gay, M. A., Díaz, F. J. Llorca, López, M. I. Rubio, Zogheib, E., Villeret, L., Nader, J., Bernasinski, M., Besserve, P., Caus, T., Dupont, H., Morimont, P., Habran, S., Hubert, R., Desaive, T., Blaffart, F., Janssen, N., Guiot, J., Pironet, A., Dauby, P., Lambermont, B., Zarantonello, F., Ballin, A., Facchin, F., Sartori, G., Campello, E., Pettenuzzo, T., Citton, G., Rossi, S., Simioni, P., Ori, C., Kirakli, C., Ediboglu, O., Ataman, S., Yarici, M., Tuksavul, F., Keating, S., Gibson, A., Gilles, M., Dunn, M., Price, G., Young, N., Remeta, P., Bishop, P., Zamora, M. D. Fernández, Muñoz-Bono, J., Curiel-Balsera, E., Aguilar-Alonso, E., Hinojosa, R., Gordillo-Brenes, A., Arboleda-Sánchez, J. A., Skorniakov, I., Vikulova, D., Whiteley, C., Shaikh, O., Jones, A., Ostermann, M., Forni, L., Scott, M., Sahatjian, J., Linde-Zwirble, W., Hansell, D., Laoveeravat, P., Srisawat, N., Kongwibulwut, M., Peerapornrattana, S., Suwachittanont, N., Wirotwan, T. O., Chatkaew, P., Saeyub, P., Latthaprecha, K., Tiranathanagul, K., Eiam-ong, S., Kellum, J. A., Berthelsen, R. E., Perner, A., Jensen, A. E. K., Jensen, J. U., Bestle, M. H., Gebhard, D. J., Price, J., Kennedy, C. E., Akcan-Arikan, A., Liberatore, A. M. A., Souza, R. B., Martins, A. M. C. R. P. F., Vieira, J. C. F., Kang, Y. R., Nakamae, M. N., Koh, I. H. J., Hamed, K., Khaled, M. M., Soliman, R. Aly, Mokhtar, M. Sherif, Seller-Pérez, G., Arias-Verdú, D., Llopar-Valdor, E., De-Diós-Chacón, I., Quesada-García, G., Herrera-Gutierrez, M. E., Hafes, R., Carroll, G., Doherty, P., Wright, C., Vera, I. G. Guerra, Ralston, M., Gemmell, M. L., MacKay, A., Black, E., Wright, C., Docking, R. I., Appleton, R., Ralston, M. R., Gemmell, L., Appleton, R., Wright, C., Docking, R. I., Black, E., Mackay, A., Rozemeijer, S., Mulier, J. L. G. Haitsma, Röttgering, J. G., Elbers, P. W. G., Spoelstra-de Man, A. M. E., Tuinman, P. R., de Waard, M. C., Oudemans-van Straaten, H. M., Mejeni, N., Nsiala, J., Kilembe, A., Akilimali, P., Thomas, G., Egerod, I., Andersson, A. E., Fagerdahl, A. M., Knudsen, V., Meddeb, K., Cheikh, A. Ben, Hamdaoui, Y., Ayachi, J., Guiga, A., Fraj, N., Romdhani, S., Sma, N., Bouneb, R., Chouchene, I., Khedher, A., Bouafia, N., Boussarsar, M., Amirian, A., Ziaian, B., Masjedi, M., Fleischmann, C., Thomas-Rueddel, D. O., Schettler, A., Schwarzkopf, D., Stacke, A., Reinhart, K., Filipe, E., Escoval, A., Martins, A., Sousa, P., Velez, N., Viegas, E., Tomas, E., Snell, G., Matsa, R., Paary, T. T. S., Kalaiselvan, M. S., Cavalheiro, A. M., Rocha, L. L., Vallone, C. S., Tonilo, A., Lobato, M. D. S., Malheiro, D. T., Sussumo, G., Lucino, N. M., Zand, F., Rosenthal, V. D., Masjedi, M., Sabetian, G., Maghsudi, B., Ghorbani, M., Dashti, A. Sanaei, Yousefipour, A., Goodall, J. R., Williamson, M., Tant, E., Thomas, N., Balci, C., Gonen, C., Haftacı, E., Gurarda, H., Karaca, E., Paldusová, B., Zýková, I., Šímová, D., Houston, S., D’Antona, L., Lloyd, J., Garnelo-Rey, V., Sosic, M., Sotosek-Tokmazic, V., Kuharic, J., Antoncic, I., Dunatov, S., Sustic, A., Chong, C. T., Sim, M., Lyovarin, T., Díaz, F. M. Acosta, Galdó, S. Narbona, Garach, M. Muñoz, Romero, O. Moreno, Bailón, A. M. Pérez, Pinel, A. Carranza, Colmenero, M., Gritsan, A., Gazenkampf, A., Korchagin, E., Dovbish, N., Lee, R. M., Lim, M. P. P., Chong, C. T., Lim, B. C. L., See, J. J., Assis, R., Filipe, F., Lopes, N., Pessoa, L., Pereira, T., Catorze, N., Aydogan, M. S., Aldasoro, C., Marchio, P., Jorda, A., Mauricio, M. D., Guerra-Ojeda, S., Gimeno-Raga, M., Colque-Cano, M., Bertomeu-Artecero, A., Aldasoro, M., Valles, S. L., Tonon, D., Triglia, T., Martin, J. C., Alessi, M. C., Bruder, N., Garrigue, P., Velly, L., Spina, S., Scaravilli, V., Marzorati, C., Colombo, E., Savo, D., Vargiolu, A., Cavenaghi, G., Citerio, G., Andrade, A. H. V., Bulgarelli, P., Araujo, J. A. P., Gonzalez, V., Souza, V. A., Costa, A., Massant, C., Filho, C. A. C. Abreu, Morbeck, R. A., Burgo, L. E., van Groenendael, R., van Eijk, L. T., Leijte, G. P., Koeneman, B., Kox, M., Pickkers, P., García-de la Torre, A., de la Torre-Prados, M., Fernández-Porcel, A., Rueda-Molina, C., Nuevo-Ortega, P., Tsvetanova-Spasova, T., Cámara-Sola, E., García-Alcántara, A., Salido-Díaz, L., Liao, X., Feng, T., Zhang, J., Cao, X., Wu, Q., Xie, Z., Li, H., Kang, Y., Winkler, M. S., Nierhaus, A., Mudersbach, E., Bauer, A., Robbe, L., Zahrte, C., Schwedhelm, E., Kluge, S., Zöllner, C., Morton, B., Mitsi, E., Pennington, S. H., Reine, J., Wright, A. D., Parker, R., Welters, I. D., Blakey, J. D., Rajam, G., Ades, E. W., Ferreira, D. M., Wang, D., Kadioglu, A., Gordon, S. B., Koch, R., Kox, M., Rahamat-Langedoen, J., Schloesser, J., de Jonge, M., Pickkers, P., Bringue, J., Guillamat-Prats, R., Torrents, E., Martinez, M. L., Camprubí-Rimblas, M., Artigas, A., Blanch, L., Park, S. Y., Park, Y. B., Song, D. K., Shrestha, S., Park, S. H., Koh, Y., Park, M. J., Hong, C. W., Lesur, O., Coquerel, D., Sainsily, X., Cote, J., Söllradl, T., Murza, A., Dumont, L., Dumaine, R., Grandbois, M., Sarret, P., Marsault, E., Salvail, D., Auger-Messier, M., Chagnon, F., Lauretta, M. P., Greco, E., Dyson, A., Singer, M., Preau, S., Ambler, M., Sigurta, A., Saeed, S., Singer, M., Sarıca, L. Topcu, Zibandeh, N., Genc, D., Gul, F., Akkoc, T., Kombak, E., Cinel, L., Akkoc, T., Cinel, I., Pollen, S. J., Arulkumaran, N., Singer, M., Torrance, H. D., Longbottom, E. R., Warnes, G., Hinds, C. J., Pennington, D. J., Brohi, K., O’Dwyer, M. J., Kim, H. Y., Na, S., Kim, J., Chang, Y. F., Chao, A., Shih, P. Y., Lee, C. T., Yeh, Y. C., Chen, L. 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R., Parlevliet, K., Boer, C., Elbers, P. W., Tuinman, P. R., Reina, Á. J. Roldán, Palomo, Y. Corcia, Bermúdez, R. Martín, Villén, L. Martín, García, I. Palacios, Izurieta, J. R. Naranjo, Bernal, J. B. Pérez, Jiménez, F. J. Jiménez, Cota-Delgado, F., de la Torre-Prados, M. V., Fernández-Porcel, A., Nuevo-Ortega, P., Cámara-Sola, E., Tsvetanova-Spasova, T., Rueda-Molina, C., Salido-Díaz, L., García-Alcántara, A., Kaneko, T., Tanaka, H., Kamikawa, M., Karashima, R., Iwashita, S., Irie, H., Kasaoka, S., Arola, O., Laitio, R., Saraste, A., Airaksinen, J., Pietilä, M., Hynninen, M., Wennervirta, J., Bäcklund, M., Ylikoski, E., Silvasti, P., Nukarinen, E., Grönlund, J., Harjola, V. P., Niiranen, J., Korpi, K., Varpula, M., Roine, R. O., Laitio, T., Salah, S., Hassen, B. G., Fehmi, A. Mohamed, Kim, S., Hsu, Y. C., Barea-Mendoza, J., García-Fuentes, C., Castillo-Jaramillo, M., Dominguez-Aguado, H., Viejo-Moreno, R., Terceros-Almanza, L., Aznárez, S. 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R., Parenti, N., Agrusta, F., Palazzi, C., Pifferi, B., Sganzerla, R., Tagliazucchi, F., Luciani, A., Möller, M., Müller-Engelmann, J., Montag, G., Adams, P., Lange, C., Neuzner, J., Gradaus, R., Wodack, K. H., Thürk, F., Waldmann, A. D., Grässler, M. F., Nishimoto, S., Böhm, S. H., Kaniusas, E., Reuter, D. A., Trepte, C. J., Sigmundsson, T., Öhman, T., Redondo, E., Hallbäck, M., Wallin, M., Sipman, F. Suarez, Oldner, A., Sander, C. Hällsjö, Björne, H., Colinas, L., Hernandez, G., Vicho, R., Serna, M., Cuena, R., Canabal, A., Chaari, A., Hakim, K. Abdel, Etman, M., El Bahr, M., El Sakka, A., Bousselmi, K., Arali, A., Kauts, V., Casey, W. F., Bond, O., De Santis, P., Iesu, E., Franchi, F., Vincent, J. L., Creteur, J., Scolletta, S., Taccone, F. S., Marutyan, Z., Hamidova, L., Shakotko, A., Movsisyan, V., Uysupova, I., Evdokimov, A., Petrikov, S., Gonen, C., Haftacı, E., Balci, C., Calvo, F. J. Redondo, Bejarano, N., Baladron, V., Villazala, R., Redondo, J., Padilla, D., Villarejo, P., Akcan-Arikan, A., Kennedy, C. E., Arzapalo, M. F. Aguilar, Gomez-Gonzalez, C., Mas-Font, S., Puppo-Moreno, A., Herrera-Gutierrez, M., Garcia-Garcia, M., Aldunate-Calvo, S., Plata-Menchaca, E. P., Pérez-Fernández, X. L., Estruch, M., Betbese-Roig, A., Campos, P. Cárdenas, Lora, M. Rojas, Gaibor, N. D. Toapanta, Medina, R. S. Contreras, Sanguino, V. D. Gumucio, Casanova, E. J., Riera, J. Sabater, Kritmetapak, K., Peerapornratana, S., Kittiskulnam, P., Dissayabutra, T., Tiranathanagul, K., Susantithapong, P., Praditpornsilpa, K., Tungsanga, K., Eiam-Ong, S., Srisawat, N., Winkelmann, T., Busch, T., Meixensberger, J., Bercker, S., Cabeza, E. M. Flores, Sánchez, M. Sánchez, Giménez, N. Cáceres, Melón, C. Gutierrez, de Lucas, E. Herrero, Estañ, P. Millán, Bernal, M. Hernández, de Lorenzo y Mateos, A. Garcia, Ergin, B., Guerci, P., Specht, P. A. C., Ince, Y., Ince, C., Balik, M., Zakharchenko, M., Los, F., Brodska, H., de Tymowski, C., Augustin, P., Desmard, M., Montravers, P., Stapel, S. N., de Boer, R., Oudemans, H. M., Hollinger, A., Schweingruber, T., Jockers, F., Dickenmann, M., Siegemund, M., Runciman, N., Ralston, M., Appleton, R., Mauri, T., Alban, L., Turrini, C., Sasso, T., Langer, T., Panigada, M., Taccone, P., Carlesso, E., Marenghi, C., Grasselli, G., Pesenti, A., Wibart, P., Reginault, T., Garcia, M., Barbrel, B., Benard, A., Bader, C., Vargas, F., Bui, H. N., Hilbert, G., Simón, J. M. Serrano, Sánchez, P. Carmona, Ferrón, F. Ruiz, de Acilu, M. García, Marin, J., Antonia, V., Ruano, L., Monica, M., Ferrer, R., Masclans, J. R., Roca, O., Hong, G., Kim, D. H., Kim, Y. S., Park, J. S., Jee, Y. K., xiang, Z. Yu, Jia-xing, W., dan, W. Xiao, long, N. Wen, Yu, W., Yan, Z., Cheng, X., Kobayashi, T., Onodera, Y., Akimoto, R., Sugiura, A., Suzuki, H., Iwabuchi, M., Nakane, M., Kawamae, K., Sanchez, P. Carmona, Rodriguez, M. D. Bautista, Delgado, M. Rodriguez, Sánchez, V. Martínez de Pinillos, Gómez, A. Mula, Simón, J. M. Serrano, Beuret, P., Fortes, C., Lauer, M., Reboul, M., Chakarian, J. C., Fabre, X., Philippon-Jouve, B., Devillez, S., Clerc, M., Rittayamai, N., Sklar, M., Dres, M., Rauseo, M., Campbell, C., West, B., Tullis, D. E., Brochard, L., Onodera, Y., Akimoto, R., Suzuki, H., Okada, M., Nakane, M., Kawamae, K., Ahmad, N., Wood, M., Glossop, A., Lucas, J. Higuera, Ortiz, A. Blandino, Alonso, D. Cabestrero, De Pablo Sánchez, R., González, L. Rey, Costa, R., Spinazzola, G., Pizza, A., Ferrone, G., Rossi, M., Antonelli, M., Conti, G., Ribeiro, H., Alves, J., Sousa, M., Reis, P., Socolovsky, C. S., Cauley, R. P., Frankel, J. E., Beam, A. L., Olaniran, K. O., Gibbons, F. K., Christopher, K. B., Pennington, J., Zolfaghari, P., King, H. S., Kong, H. H. Y., Shum, H. P., Yan, W. W., Kaymak, C., Okumus, N., Sari, A., Erdogdu, B., Aksun, S., Basar, H., Ozcan, A., Ozcan, N., Oztuna, D., Malmgren, J. A., Lundin, S., Torén, K., Eckerström, M., Wallin, A., Waldenström, A. C., Riccio, F. C., Pogson, D., Antonio, A. C. P., Leivas, A. F., Kenji, F., James, E., Morgan, P., Carroll, G., Gemmell, L., MacKay, A., Wright, C., Ballantyne, J., Jonnada, S., Gerrard, C. S., Jones, N., Salciccioli, J. D., Marshall, D. C., Komorowski, M., Hartley, A., Sykes, M. C., Goodson, R., Shalhoub, J., Villanueva, J. R. Fernández, Garda, R. Fernández, Lago, A. M. López, Ruiz, E. Rodríguez, Vaquero, R. Hernández, Rodríguez, C. Galbán, Pérez, E. Varo, Hilasque, C., Oliva, I., Sirgo, G., Martin, M. C., Olona, M., Gilavert, M. C., Bodí, M., Ebm, C., Aggarwal, G., Huddart, S., Quiney, N., Cecconi, M., Fernandes, S. M., Silva, J. Santos, Gouveia, J., Silva, D., Marques, R., Bento, H., Alvarez, A., Silva, Z. Costa, Diaz, D. Díaz, Martínez, M. Villanova, Herrejon, E. Palencia, de la Gandara, A. Martinez, Gonzalo, G., Lopez, M. A., de Gopegui Miguelena, P. Ruíz, Matilla, C. I. Bernal, Chueca, P. Sánchez, Longares, M. D. C. Rodríguez, Abril, R. Ramos, Aguilar, A. L. Ruíz, de Murillas, R. Garrido López, Fernández, R. Fernández, Laborías, P. Morales, Castellanos, M. A. Díaz, Laborías, M. E. Morales, Cho, J., Kim, J., Park, J., Woo, S., West, T., Powell, E., Rimmer, A., Orford, C., Jones, N., Williams, J., Matilla, C. I. Bernal, de Gopegui Miguelena, P. Ruiz, Chueca, P. Sánchez, Abril, R. Ramos, Longares, M. D. C. Rodríguez, Aguilar, A. L. Ruíz, de Murillas, R. Garrido López, Bourne, R. S., Shulman, R., Tomlin, M., Mills, G. H., Borthwick, M., Berry, W., Huertas, D. García, Manzano, F., Villagrán-Ramírez, F., Ruiz-Perea, A., Rodríguez-Mejías, C., Santiago-Ruiz, F., Colmenero-Ruiz, M., König, C., Matt, B., Kortgen, A., Hartog, C. S., Wong, A., Balan, C., Barker, G., Srisawat, N., Peerapornratana, S., Laoveeravat, P., Tachaboon, S., Eiam-ong, S., Paratz, J., Kayambu, G., Boots, R., Arzapalo, M. F. Aguilar, Vlasenko, R., Gromova, E., Loginov, S., Kiselevskiy, M., Dolgikova, Y., Tang, K. B., Chau, C. M., Lam, K. N., Gil, E., Suh, G. Y., Park, C. M., Park, J., Chung, C. R., Lee, C. T., Chao, A., Shih, P. Y., Chang, Y. F., Lai, C. H., Hsu, Y. C., Yeh, Y. C., Cheng, Y. J., Colella, V., Zarrillo, N., D’Amico, M., Forfori, F., Pezza, B., Laddomada, T., Beltramelli, V., Pizzaballa, M. L., Doronzio, A., Balicco, B., Kiers, D., van der Heijden, W., Gerretsen, J., de Mast, Q., el Messaoudi, S., Rongen, G., Gomes, M., Kox, M., Pickkers, P., Riksen, N. P., Kashiwagi, Y., Okada, M., Hayashi, K., Inagaki, Y., Fujita, S., Nakamae, M. N., Kang, Y. R., Souza, R. B., Liberatore, A. M. A., Koh, I. H. J., Blet, A., Sadoune, M., Lemarié, J., Bihry, N., Bern, R., Polidano, E., Merval, R., Launay, J. M., Lévy, B., Samuel, J. L., Mebazaa, A., Hartmann, J., Harm, S., and Weber, V.

Published
2016
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12. Predictive factors of six-week mortality in critically ill patients with SARS COV 2: a multicenter prospective study

Author

Estella, Á, Garcia Garmendia, J L, de la Fuente, C, Machado Casas, J F, Yuste, M E, Amaya Villar, R, Estecha, M A, Yaguez Mateos, L, Cantón Bulnes, M L, Loza, A, Mora, J, Fernández Ruiz, L, Díez Del Corral Fernández, B, Rojas Amezcua, M, Rodriguez Higueras, M I, Díaz Torres, I, Recuerda Núñez, M, Zaheri Beryanaki, M, Rivera Espinar, F, Matallana Zapata, D F, Moreno Cano, S G, Gimenez Beltrán, B, Muñoz, N, Sainz de Baranda Piñero, A, Bustelo Bueno, P, Moreno Barriga, E, Rios Toro, J J, Pérez Ruiz, M, Gómez González, C, Breval Flores, A, de San José Bermejo Gómez, A, Ruiz Cabello Jimenez, M A, Guerrero Marín, M, Ortega Ordiales, A, Tejero-Aranguren, J, Rodriguez Mejías, C, Gomez de Oña, J, de la Hoz, C, Ocaña Fernández, D, Ibañez Cuadros, S, Garnacho Montero, J, and Work Group of Infectious Disease (GTEI) de la Sociedad Andaluza de Medicina Intensiva y Unidades coronarias SAMIUC

Subjects
Male, medicine.medical_specialty, medicine.medical_treatment, Critical Illness, Lopinavir/ritonavir, Critical Care and Intensive Care Medicine, Lopinavir, Article, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, Intensive care, Internal medicine, medicine, Corticosteroids, Humans, Renal replacement therapy, Hospital Mortality, Prospective Studies, Prospective cohort study, Ritonavir, business.industry, Proportional hazards model, SARS-CoV-2, COVID-19, Infant, 030208 emergency & critical care medicine, Tocilizumab, Middle Aged, Corticoides, 030228 respiratory system, Propensity score matching, ICU, UCI, SOFA score, Female, business, medicine.drug, Cohort study
Abstract

The objective of the study is to identify the risk factors associated with mortality at six weeks, especially by analyzing the role of antivirals and munomodulators. Prospective descriptive multicenter cohort study. 26 Intensive care units (ICU) from Andalusian region in Spain. Consecutive critically ill patients with confirmed SARS-CoV-2 infection were included from March 8 to May 30. None. Variables analyzed were demographic, severity scores and clinical condition. Support therapy, drug and mortality were analyzed. An univariate followed by multivariate Cox regression with propensity score analysis was applied. 495 patients were enrolled, but 73 of them were excluded for incomplete data. Thus, 422 patients were included in the final analysis. Median age was 63 years and 305 (72.3%) were men. ICU mortality: 144/422 34%; 14 days mortality: 81/422 (19.2%); 28 days mortality: 121/422 (28.7%); 6-week mortality 152/422 36.5%. By multivariable Cox proportional analysis, factors independently associated with 42-day mortality were age, APACHE II score, SOFA score at ICU admission >6, Lactate dehydrogenase at ICU admission >470U/L, Use of vasopressors, extrarenal depuration, %lymphocytes 72h post-ICU admission 6, Lactate dehydrogenase at ICU admission >470U/L, Use of vasopressors, extrarenal depuration, %lymphocytes 72h post-ICU admission 470U/L, Use of vasopressors, extrarenal depuration, %lymphocytes 72h post-ICU admission Age, APACHE II, SOFA>value of 6 points, along with vasopressor requirements or renal replacement therapy have been identified as predictor factors of mortality at six weeks. Administration of corticosteroids showed no benefits in mortality, as did treatment with tocilizumab. Lopinavir/ritonavir administration is identified as a protective factor.

Published
2021

13. Exploration of galectin ligands displayed on gram-negative respiratory bacterial pathogens with different cell surface architectures

Author

Ministerio de Ciencia, Innovación y Universidades (España), Instituto de Salud Carlos III, Campanero-Rhodes, María Asunción, Kalograiaki, Ioanna, Euba, Begoña, Llobet, E., Ardá, Ana, Jiménez-Barbero, Jesús, Garmendia, J., Solís, Dolores, Ministerio de Ciencia, Innovación y Universidades (España), Instituto de Salud Carlos III, Campanero-Rhodes, María Asunción, Kalograiaki, Ioanna, Euba, Begoña, Llobet, E., Ardá, Ana, Jiménez-Barbero, Jesús, Garmendia, J., and Solís, Dolores

Abstract

Galectins bind various pathogens through recognition of distinct carbohydrate structures. In this work, we examined the binding of four human galectins to the Gram-negative bacteria Klebsiella pneumoniae (Kpn) and non-typeable Haemophilus influenzae (NTHi), which display different surface glycans. In particular, Kpn cells are covered by a polysaccharide capsule and display an O-chain-containing lipopolysaccharide (LPS), whereas NTHi is not capsulated and its LPS, termed lipooligosacccharide (LOS), does not contain O-chain. Binding assays to microarray-printed bacteria revealed that galectins-3, -4, and -8, but not galectin-1, bind to Kpn and NTHi cells, and confocal microscopy attested binding to bacterial cells in suspension. The three galectins bound to array-printed Kpn LPS. Moreover, analysis of galectin binding to mutant Kpn cells evidenced that the O-chain is the docking point for galectins on wild type Kpn. Galectins-3, -4, and -8 also bound the NTHi LOS. Microarray-assisted comparison of the binding to full-length and truncated LOSs, as well as to wild type and mutant cells, supported LOS involvement in galectin binding to NTHi. However, deletion of the entire LOS oligosaccharide chain actually increased binding to NTHi cells, indicating the availability of other ligands on the bacterial surface, as similarly inferred for Kpn cells devoid of both O-chain and capsule. Altogether, the results illustrate galectins’ versatility for recognizing different bacterial structures, and point out the occurrence of so far overlooked galectin ligands on bacterial surfaces.

Published
2021

15. Visualization of DNA-protein intermediates during activation of the Pu promoter of the TOL plasmid of Pseudomonas putida

Author

Garmendia, J. and De Lorenzo, V.

Subjects
Cytochemistry -- Research, Bacterial genetics -- Research, Plasmids -- Physiological aspects, DNA -- Physiological aspects, Pseudomonas putida -- Genetic aspects, Cellular control mechanisms -- Research, Variation (Biology) -- Physiological aspects, Transmission electron microscopes -- Usage, Adenosine triphosphate -- Physiological aspects, Genetic transcription -- Regulation, Biological sciences
Abstract

DNA-protein intermediates in activation of the Pu promoter of the TOL plasmid of Pseudomonas putida has been visualized. Transmission electron microscopy was used to look at the ATP-dependent multimerization process undergone by the sigma(super.54) dependent activator XylR of the TOL plasmid pWW0 of P. putida when bound to the upstream activating sequences of the cognate Pu promoter. It appears, based on this study, that each time ATP is hydrolyzed the transcriptional activation complex is taken apart.

Published
2000

16. A multidrug-resistant microorganism infection risk prediction model: development and validation in an emergency medicine population

Author

del Castillo J, Julian-Jimenez A, Gamazo-Del Rio J, Garcia-Lamberechts E, Llopis-Roca F, Tey J, de Zarate M, Bustos C, Salmeron P, Alvarez-Manzanares J, Romero M, Grinspan M, Gutierrez S, Martin-Sanchez F, Gonzalez F, Borrego B, Rodrigo I, Corrochano E, del Campo K, Martinez L, Belloso M, Soriano S, Ramos A, Xanco C, Martinez C, Munoz C, Gonzalez E, Aguilar N, Rodriguez V, Rodriguez A, Diaz J, Flores M, Cana C, Loranca M, Pareja R, Galan J, Beliz O, Ramirez J, Suberviola A, Moreno B, Rodriguez J, Rodrigo S, del Blanco C, Ruano O, Pena M, Canovas J, Gutierrez C, Garmendia J, Prieto S, Garcia V, Moll M, Gallego M, Arranz R, Sanchez M, Bonilla F, Luperena J, Gomez A, Garcia A, Martin L, Hermida A, Moreno M, Mocanu C, Calvo C, Diaz-Guerra M, Leal C, Yebes N, Pizarro A, Galan C, Teleki A, Guijorro N, Rua M, Murillo E, Mulet M, Ubago A, Poveda C, Garcia R, de Santos F, del Val S, Hortoneda M, Isidro I, Fernandez B, Domingo L, Torresano M, Torres A, Otero L, Ricoy L, Molina I, Roca M, Mateo S, Roig M, Andion M, Sansone L, Reus F, Motto E, Fajardo L, Valencia M, Romero R, Cerdan M, Belvis J, Morata M, Pineda M, Asensio C, Rodriguez E, Toldos C, Perales R, Sanchez A, Ordenana I, Borras M, Bargallo L, Vazquez E, Arenas M, Maimo M, Ruiz F, Aznar N, Martinez S, Redondo G, Carballo C, Quiros A, Paredes M, Gallego-Acho P, Barco J, Alvira R, Garcia F, Martin A, Izquierdo R, Ramos J, Pardal A, Castrodeza M, Aguirre R, Pelaez J, Fernandez-Bermejo M, Serrano C, Gallar P, David M, Orantos M, Putze G, Gomez M, Perez C, Sanz I, Querejeta A, Anza D, Martin-Penaranda T, Aguirre A, Betegon M, Ruiz M, Moreno A, Santos L, de Sosa S, Lafont M, Montoya M, Noriega A, Rodriguez G, Rocamora J, Vicente L, Escudero I, Morcillo A, Dominguez A, Ayala M, Espinosa P, Mebuy A, Latorre F, de Valderrama M, Crepo C, Francia B, Perez-Reverte F, Diaz M, Saldumbide S, Quevedo J, Vela M, Gilmartin L, Fernandez R, Natal I, Huerga S, Orus M, Martinez F, Olmeda D, Varea P, Criado J, Garcia M, Galindo A, Avellaneda C, Hernandez F, Penalver C, Onate J, Grima M, Garcia D, Edo I, Rodriguez M, Entrala B, Amez J, Clemens R, Olivares M, Esteban M, Ortega A, Slaoui H, Palmerin J, Mota M, Inchauspe F, Gorrotxategi A, Gamito G, Quesada S, Ungerer O, Urraca A, Brezmez M, Mendia I, Pinto D, Ordonez B, Navarro R, Navarro S, Fernandez E, Macias A, Jimenez M, Martin S, Canovas E, Marin S, Cayuela G, Nicolas J, Fernandez M, Barroso I, Bautista J, Hostalet F, and INFURG-SEMES Investigators

Subjects
Antibiotic resistant, Risk factors, Stewardship, MDRO, Empirical antibiotic treatment
Abstract

The aim was to develop a predictive model of infection by multidrug-resistant microorganisms (MDRO). A national, retrospective cohort study was carried out including all patients attended for an infectious disease in 54 Spanish Emergency Departments (ED), in whom a microbiological isolation was available from a culture obtained during their attention in the ED. A MDRO infection prediction model was created in a derivation cohort using backward logistic regression. Those variables significant at p < 0.05 assigned an integer score proportional to the regression coefficient. The model was then internally validated by k-fold cross-validation and in the validation cohort. A total of 5460 patients were included; 1345 (24.6%) were considered to have a MDRO infection. Twelve independent risk factors were identified in the derivation cohort and were combined into an overall score, the ATM (assessment of threat for MDRO) score. The model achieved an area under the curve-receiver operating curve of 0.76 (CI 95% 0.74-0.78) in the derivation cohort and 0.72 (CI 95% 0.70-0.75) in the validation cohort (p = 0.0584). Patients were then split into 6 risk categories and had the following rates of risk: 7% (0-2 points), 16% (3-5 points), 24% (6-9 points), 33% (10-14 points), 47% (15-21 points), and 71% (> 21 points). Findings were similar in the validation cohort. Several patient-specific factors were independently associated with MDRO infection risk. When integrated into a clinical prediction rule, higher risk scores and risk classes were related to an increased risk for MDRO infection. This clinical prediction rule could be used by providers to identify patients at high risk and help to guide antibiotic strategy decisions, while accounting for clinical judgment.

Published
2020

17. Posters

Author

Ryan, D. W., Belyaev S., Rudnov V., Mironov A., Bhagwanjee, S., Muckart, D. J. J., Hodgson, R. E., Afessa, B., Meyers, B., Koch, K., Delke, I., Schelline, G., Meier, M., Haller, M., Briegel, J., Schüffel, W., Peter, K., Jones, C., Griffiths, R. D., Macmillan, R. R., Harris, C., Colardyn, F. A., Dheene, P., Danneels, C., Verstraete, A., Burn, L., Dawsen, B., Baudouin, S. V., Stoll, C., Schelling, G., Bullinger, M., Stott, S. A., Noble, D. W., Weir, J., Vesely, H., Gregor, Th., Defouillov, C., Defouilloy, I., Dimov, G., Tinturier, F., Slama, M., Ossart, M., Rosengaard, L. Bredahl, Eriksen, K., Nielsen, P. Rotbøll, Heslet, L., Moreno, R., Miranda, D. Reis, Fidler, V., Apolone, G., Sicignano, A., Carozzi, C., Giudici, D., Merli, G., Pulici, M., Gaillard, M., Emmanuelli, J., Hervé, C., Davous, H., Beck, D. H., Taylor, B. L., Smith, G. B., Paionk, F. G., Waydhas, C., Fischer, A., Duswald, K. H., Jiménez, M. J., del Nogal, F., Martín, A., Díaz, R., López, J., Suárez, J., Algora, A., Singer, M., Groeneveld, A. B. J., Bossink, A. W. K., Hack, C. E., Thijs, L. G., Mata, G. Vazquez, Fernandez, R. Rivera, Paeec, Proyecto, Schulze, K., Verner, Lj., Logemann, F., Kirchner, E., Garnacho-Montero, J., García-Garmendia, J. L., Ortiz-Leyba, C., Rincón-Ferrari, M. D., Villar, J. Monterrubio, Jiménez-Jiménez, F. J., Jiménez-Jiménez, L. M., Armaganidis, A., Dimitriadou, E., Kaltsas, P., Charisis, A., Pontikis, X., Roussos, Ch., Platsouka, E., Routsi, Ch., Markaki, V., Paniara, O., Young, J. D., Newton, B., Rowan, K., Jara, F., Naya, J. M., Cherta, I., Quíntana, S., Vázquez, P., Alvarez, M., Perez, J. Martinez, Garcia-Bach, M., Aparicio, A., Vila, F., Rué, M., Valero, C., Quintana, S., Artigas, A., Linde-Zwirble, W. T., Clermont, G., Coleman, M. B., Brodak, S., Angus, D. C., Dougnac, A., Hernandez, G., Ojeda, M., Castro, J., Labarca, E., Castillo, L., Andresen, M., Bugedo, G., Diaz, O., Arriagada, D., Dagnino, J., Pinsky, M. R., Newbold, R. C., Tampubolon, O. E., Iskandar, S., Siahaan, M., Suntoro, A., Albert, A., Fongaro, A., Carlot, A., Sattin, A., ARCHIDIA, and ICNARC Working Group on coding conditions in intensive care

Published
1996
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19. Antimicrobial de-escalation in the critically ill patient and assessment of clinical cure: the DIANA study

Author

De Bus, L., Depuydt, P., Steen, J., Dhaese, S., De Smet, K., Tabah, A., Akova, M., Cotta, M. O., De Pascale, Gennaro, Dimopoulos, G., Fujitani, S., Garnacho-Montero, J., Leone, M., Lipman, J., Ostermann, M., Paiva, J. -A., Schouten, J., Sjovall, F., Timsit, J. -F., Roberts, J. A., Zahar, J. -R., Zand, F., Zirpe, K., De Waele, J. J., Rios, F., Vazquez, A. R., Vidal, M. G., Zakalik, G., Attokaran, A. G., Banakh, I., Dey-Chatterjee, S., Ewan, J., Ferrier, J., Forbes, L., Fourie, C., Leditschke, A., Murray, L., Eller, P., Biston, P., Bracke, S., De Crop, L., De Schryver, N., Frans, E., Spapen, H., Van Malderen, C., Vansteelandt, S., Vermeiren, D., Arevalo, E. P., Crespo, M., Flores, R. Z., Piza, P., Tutillo, D. M., Elme, A., Kallaste, A., Starkopf, J., Bourenne, J., Calypso, M., Cohen, Y., Dahyot-Fizelier, C., Depret, F., Guillot, M., Imzi, N., Jochmans, S., Kouatchet, A., Lepape, A., Martin, O., Heim, M., Schaller, S. J., Arvaniti, K., Bekridelis, A., Ioannidis, P., Mitrakos, C., Papanikolaou, M. N., Pouriki, S., Vemvetsou, A., Abraham, B., Bhattacharya, P. K., Budugu, A., Dixit, S., Gurav, S., Kandanuri, P., Prabhu, D. A., Rathod, D., Savaru, K., Udupa, A. N., Varghese, S. B., Bakhodaei, H. H., Dabiri, G., Fallahi, M. J., Feiz, F., Firoozifar, M., Khaloo, V., Maghsudi, B., Masjedi, M., Nikandish, R., Sabetian, G., Marsh, B., Martin-Loeches, I., Steiner, J., Barbagallo, M., Caricato, Anselmo, Cortegiani, A., D'Andrea, R., Deana, C., Donati, A., Girardis, M., Mandala, G., Panarello, G., Pasero, D., Pelagalli, L., Soave, Paolo Maurizio, Spadaro, S., Fujita, Y., Fujiwara, S., Hara, Y., Hashi, H., Hashimoto, S., Hashimoto, H., Hayakawa, K., Inoue, M., Isokawa, S., Kameda, S., Kamohara, H., Kanamoto, M., Katayama, S., Kawagishi, T., Kawano, Y., Kida, Y., Kita, M., Kobayashi, A., Kuriyama, A., Naito, T., Nashiki, H., Nishiyama, K., Shindo, S., Suzuki, T., Takaba, A., Tanaka, C., Tetsuya, K., Tomioka, Y., Yanagawa, Y., Yoshida, H., Adnan, S., Hasan, M. S., Sulaiman, H., Gasca Lopez, G. A., Hernandez-Cardenas, C. M., Namendys-Silva, S. A., Bethlehem, C., de Lange, D., Hunfeld, N., Numan, S., van Leeuwen, H., Owens, D., Almeida, M., Fragoso, E., Leonor, T., Pereira, J. -M., Filipescu, D., Grigoras, I., Popescu, M., Tomescu, D., Alshahrani, M. S., Alvarez-Gonzalez, M., Barrero-Garcia, I., Blasco-Navalpotro, M. A., Claverias, L., Estella, A., Espina, L. F., Garmendia, J. L. G., Prieto, E. G., Gomez-Prieto, G., Conde, C. J., Sagasti, F. M., Cantero, A. M., Orejas-Gallego, A., Papiol, E., Perez-Civantos, D., Laderas, J. C. P., Alvarez, J. T., Vera-Artazcoz, P., Cortes, P. V., Oldner, A., Spangfors, M., Alp, E., Koksal, I., Korten, V., Ozveren, A., Hall, A., Hatton, K. W., Laudanski, K., De Pascale G. (ORCID:0000-0002-8255-0676), Caricato A. (ORCID:0000-0001-5929-120X), Soave P. M., De Bus, L., Depuydt, P., Steen, J., Dhaese, S., De Smet, K., Tabah, A., Akova, M., Cotta, M. O., De Pascale, Gennaro, Dimopoulos, G., Fujitani, S., Garnacho-Montero, J., Leone, M., Lipman, J., Ostermann, M., Paiva, J. -A., Schouten, J., Sjovall, F., Timsit, J. -F., Roberts, J. A., Zahar, J. -R., Zand, F., Zirpe, K., De Waele, J. J., Rios, F., Vazquez, A. R., Vidal, M. G., Zakalik, G., Attokaran, A. G., Banakh, I., Dey-Chatterjee, S., Ewan, J., Ferrier, J., Forbes, L., Fourie, C., Leditschke, A., Murray, L., Eller, P., Biston, P., Bracke, S., De Crop, L., De Schryver, N., Frans, E., Spapen, H., Van Malderen, C., Vansteelandt, S., Vermeiren, D., Arevalo, E. P., Crespo, M., Flores, R. Z., Piza, P., Tutillo, D. M., Elme, A., Kallaste, A., Starkopf, J., Bourenne, J., Calypso, M., Cohen, Y., Dahyot-Fizelier, C., Depret, F., Guillot, M., Imzi, N., Jochmans, S., Kouatchet, A., Lepape, A., Martin, O., Heim, M., Schaller, S. J., Arvaniti, K., Bekridelis, A., Ioannidis, P., Mitrakos, C., Papanikolaou, M. N., Pouriki, S., Vemvetsou, A., Abraham, B., Bhattacharya, P. K., Budugu, A., Dixit, S., Gurav, S., Kandanuri, P., Prabhu, D. A., Rathod, D., Savaru, K., Udupa, A. N., Varghese, S. B., Bakhodaei, H. H., Dabiri, G., Fallahi, M. J., Feiz, F., Firoozifar, M., Khaloo, V., Maghsudi, B., Masjedi, M., Nikandish, R., Sabetian, G., Marsh, B., Martin-Loeches, I., Steiner, J., Barbagallo, M., Caricato, Anselmo, Cortegiani, A., D'Andrea, R., Deana, C., Donati, A., Girardis, M., Mandala, G., Panarello, G., Pasero, D., Pelagalli, L., Soave, Paolo Maurizio, Spadaro, S., Fujita, Y., Fujiwara, S., Hara, Y., Hashi, H., Hashimoto, S., Hashimoto, H., Hayakawa, K., Inoue, M., Isokawa, S., Kameda, S., Kamohara, H., Kanamoto, M., Katayama, S., Kawagishi, T., Kawano, Y., Kida, Y., Kita, M., Kobayashi, A., Kuriyama, A., Naito, T., Nashiki, H., Nishiyama, K., Shindo, S., Suzuki, T., Takaba, A., Tanaka, C., Tetsuya, K., Tomioka, Y., Yanagawa, Y., Yoshida, H., Adnan, S., Hasan, M. S., Sulaiman, H., Gasca Lopez, G. A., Hernandez-Cardenas, C. M., Namendys-Silva, S. A., Bethlehem, C., de Lange, D., Hunfeld, N., Numan, S., van Leeuwen, H., Owens, D., Almeida, M., Fragoso, E., Leonor, T., Pereira, J. -M., Filipescu, D., Grigoras, I., Popescu, M., Tomescu, D., Alshahrani, M. S., Alvarez-Gonzalez, M., Barrero-Garcia, I., Blasco-Navalpotro, M. A., Claverias, L., Estella, A., Espina, L. F., Garmendia, J. L. G., Prieto, E. G., Gomez-Prieto, G., Conde, C. J., Sagasti, F. M., Cantero, A. M., Orejas-Gallego, A., Papiol, E., Perez-Civantos, D., Laderas, J. C. P., Alvarez, J. T., Vera-Artazcoz, P., Cortes, P. V., Oldner, A., Spangfors, M., Alp, E., Koksal, I., Korten, V., Ozveren, A., Hall, A., Hatton, K. W., Laudanski, K., De Pascale G. (ORCID:0000-0002-8255-0676), Caricato A. (ORCID:0000-0001-5929-120X), and Soave P. M.

Abstract

Purpose: The DIANA study aimed to evaluate how often antimicrobial de-escalation (ADE) of empirical treatment is performed in the intensive care unit (ICU) and to estimate the effect of ADE on clinical cure on day 7 following treatment initiation. Methods: Adult ICU patients receiving empirical antimicrobial therapy for bacterial infection were studied in a prospective observational study from October 2016 until May 2018. ADE was defined as (1) discontinuation of an antimicrobial in case of empirical combination therapy or (2) replacement of an antimicrobial with the intention to narrow the antimicrobial spectrum, within the first 3 days of therapy. Inverse probability (IP) weighting was used to account for time-varying confounding when estimating the effect of ADE on clinical cure. Results: Overall, 1495 patients from 152 ICUs in 28 countries were studied. Combination therapy was prescribed in 50%, and carbapenems were prescribed in 26% of patients. Empirical therapy underwent ADE, no change and change other than ADE within the first 3 days in 16%, 63% and 22%, respectively. Unadjusted mortality at day 28 was 15.8% in the ADE cohort and 19.4% in patients with no change [p = 0.27; RR 0.83 (95% CI 0.60–1.14)]. The IP-weighted relative risk estimate for clinical cure comparing ADE with no-ADE patients (no change or change other than ADE) was 1.37 (95% CI 1.14–1.64). Conclusion: ADE was infrequently applied in critically ill-infected patients. The observational effect estimate on clinical cure suggested no deleterious impact of ADE compared to no-ADE. However, residual confounding is likely.

Published
2020

22. LIMPET ANAPHYLAXIS : 357

Author

Joral, A., Navarro, J. A., Villas, F., Garmendia, J., and Villarreal, O.

Published
1997

24. Incidence and outcome of invasive candidiasis in intensive care units (icus) in europe: Results of the eucandicu project

Author

Bassetti, M., Giacobbe, D. R., Vena, A., Trucchi, C., Ansaldi, F., Antonelli, Massimo, Adamkova, V., Alicino, Monica, Almyroudi, M. -P., Atchade, E., Azzini, A. M., Carannante, N., Carnelutti, A., Corcione, S., Cortegiani, A., Dimopoulos, G., Dubler, S., Garcia-Garmendia, J. L., Girardis, M., Cornely, O. A., Ianniruberto, S., Kullberg, B. J., Lagrou, K., Le Bihan, C., Luzzati, R., Malbrain, M. L. N. G., Merelli, M., Marques, A. J., Martin-Loeches, I., Mesini, A., Paiva, J. -A., Peghin, M., Raineri, S. M., Rautemaa-Richardson, R., Schouten, J., Brugnaro, P., Spapen, H., Tasioudis, P., Timsit, J. -F., Tisa, V., Tumbarello, Mario, Van Den Berg, C. H. S. B., Veber, B., Venditti, Mario, Voiriot, G., Wauters, J., Montravers, P., Antonelli M. (ORCID:0000-0003-3007-1670), Alicino C., Tumbarello M. (ORCID:0000-0002-9519-8552), Venditti M., Bassetti, M., Giacobbe, D. R., Vena, A., Trucchi, C., Ansaldi, F., Antonelli, Massimo, Adamkova, V., Alicino, Monica, Almyroudi, M. -P., Atchade, E., Azzini, A. M., Carannante, N., Carnelutti, A., Corcione, S., Cortegiani, A., Dimopoulos, G., Dubler, S., Garcia-Garmendia, J. L., Girardis, M., Cornely, O. A., Ianniruberto, S., Kullberg, B. J., Lagrou, K., Le Bihan, C., Luzzati, R., Malbrain, M. L. N. G., Merelli, M., Marques, A. J., Martin-Loeches, I., Mesini, A., Paiva, J. -A., Peghin, M., Raineri, S. M., Rautemaa-Richardson, R., Schouten, J., Brugnaro, P., Spapen, H., Tasioudis, P., Timsit, J. -F., Tisa, V., Tumbarello, Mario, Van Den Berg, C. H. S. B., Veber, B., Venditti, Mario, Voiriot, G., Wauters, J., Montravers, P., Antonelli M. (ORCID:0000-0003-3007-1670), Alicino C., Tumbarello M. (ORCID:0000-0002-9519-8552), and Venditti M.

Abstract

Background: The objective of this study was to assess the cumulative incidence of invasive candidiasis (IC) in intensive care units (ICUs) in Europe. Methods: A multinational, multicenter, retrospective study was conducted in 23 ICUs in 9 European countries, representing the first phase of the candidemia/intra-abdominal candidiasis in European ICU project (EUCANDICU). Results: During the study period, 570 episodes of ICU-acquired IC were observed, with a cumulative incidence of 7.07 episodes per 1000 ICU admissions, with important between-center variability. Separated, non-mutually exclusive cumulative incidences of candidemia and IAC were 5.52 and 1.84 episodes per 1000 ICU admissions, respectively. Crude 30-day mortality was 42%. Age (odds ratio [OR] 1.04 per year, 95% CI 1.02-1.06, p < 0.001), severe hepatic failure (OR 3.25, 95% 1.31-8.08, p 0.011), SOFA score at the onset of IC (OR 1.11 per point, 95% CI 1.04-1.17, p 0.001), and septic shock (OR 2.12, 95% CI 1.24-3.63, p 0.006) were associated with increased 30-day mortality in a secondary, exploratory analysis. Conclusions: The cumulative incidence of IC in 23 European ICUs was 7.07 episodes per 1000 ICU admissions. Future in-depth analyses will allow explaining part of the observed between-center variability, with the ultimate aim of helping to improve local infection control and antifungal stewardship projects and interventions.

Published
2019

25. Distribución espacial y análisis ambiental de las plantas raras de los Pirineos

Author

Gómez, D., Lorda, M., Garmendia, J., and García, M. B.

Subjects
corología, habitat naturalness, Pyrenees, formas biológicas, Altitudinal distribution, hábitats, naturalidad, habitats, Pirineos, lcsh:QH540-549.5, life-forms, rarity, lcsh:Ecology, chorology, Distribución altitudinal, rareza
Abstract

The recent digital edition of the Atlas of Pyrenean vascular flora, allow us to analyze some patterns of geographical distribution and environmental features of the most rare plant species. The aim of our study is to contribute to the knowledge of rarity and to the planning and implementation of plant conservation at a Pyrenean scale. Among the 363 selected taxa after applying the criteria of low occupancy (10% of the whole Pyrenean flora), 352 are present in less of the 2% of the territory and 11 occupy less than 4% distributed over a scarce number of populations (less than 30). Using a net of 10 x 10 Km UTM’s squares, rare plants appear represented in the 65% of the territory; the regions with highest rare plant density overlap those with the highest total plant number. The areas with the richest rare plants are placed at the East and West extremes (beside the Cap de Creus and at between San Sebastian and Irun respectively), at the center of the French National Park of the Pyrenees and the surroundings of the Spanish Monte Perdido area. Rare flora significantly differs from the whole flora in terms of taxonomic representation, altitudinal amplitude and distribution, chorology, life-forms, edaphic preference and habitats, but not in the naturalness of the habitats where they occur. La reciente edición en línea del Atlas digital de Flora vascular de los Pirineos permite analizar algunos patrones de la distribución y las preferencias ambientales de las plantas más raras, con el fin de contribuir a la caracterización de la rareza y al diseño de estrategias de conservación de la diversidad florística en la cordillera. Entre los 363 taxones seleccionados por su escasa representación (el 10% del total de la flora) 352 se distribuyen en menos del 2% del territorio y 11 ocupan un área inferior al 4%, pero tienen menos de 30 de poblaciones en todo el territorio. La flora rara se distribuye en el 65% de los Pirineos (utilizando para esta estima una malla de cuadrículas UTM de 10 Km de lado), y las regiones con más abundancia de plantas raras coinciden con las que tienen mayor diversidad florística total. Las zonas con mayor densidad de plantas raras se sitúan en el extremo oriental (junto al Cap de Creus), el noroccidental (entre San Sebastián e Irún) y en el centro del Parc National des Pyrénées y los alrededores de Monte Perdido. La flora rara se muestra significativamente diferente del conjunto de la flora en su representación taxonómica, distribución y amplitud altitudinal, corología, formas biológicas, preferencia edáfica y hábitats, pero no en el grado de naturalidad de los hábitats.

Published
2017
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26. Posters

Author

Afessa, B., Ivaškcyičius, J., Vosylius, S., Šipylaite, J., Benham, S. W., Kinsella, J., Fretschner, R., Heininger, A., Kottler, B., Wehrle, A., Nikonov, S., Yakushenko, O., Bajbikov, V., Zhdanov, O., Sulima, E., Pyasetskaya, N., Korol, E., Lelchuk, E., Kashpur, E., Garnacho-Montero, J., Ortiz-Leyba, C., Jiménez-Jiménez, F. J., Fernández-Vega, M. D., Pérez-Paredes, C., Garcia-Garmendia, J. L., Vangerow, B., Rueckoldt, H., Marx, G., Jankowski, M., and Piepenbrock, S.

Published
1996
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27. Seasonal and latitudinal variation in seagrass mechanical traits across Europe: The influence of local nutrient status and morphometric plasticity

Author

Soissons, L. M., primary, van Katwijk, M. M., additional, Peralta, G., additional, Brun, F. G., additional, Cardoso, P. G., additional, Grilo, T. F., additional, Ondiviela, B., additional, Recio, M., additional, Valle, M., additional, Garmendia, J. M., additional, Ganthy, F., additional, Auby, I., additional, Rigouin, L., additional, Godet, L., additional, Fournier, J., additional, Desroy, N., additional, Barillé, L., additional, Kadel, P., additional, Asmus, R., additional, Herman, P. M. J., additional, and Bouma, T. J., additional

Published
2017
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29. Klebsiella pneumoniae survives within macrophages by avoiding delivery to lysosomes

Author

Cano, V., March, C., Insua, J.L., Aguiló, N., Llobet, E., Moranta, D., Regueiro, V., Brennan, G.P., Millán-Lou, M.I., Martín, C., Garmendia, J., Bengoechea, J.A., Ministerio de Economía y Competitividad (España), Govern de les Illes Balears, Instituto de Salud Carlos III, Queen's University Belfast, European Commission, and Centro de Investigación Biomédica en Red Enfermedades Respiratorias (España)

Abstract

Klebsiella pneumoniae is an important cause of community-acquired and nosocomial pneumonia. Evidence indicates that Klebsiella might be able to persist intracellularly within a vacuolar compartment. This study was designed to investigate the interaction between Klebsiella and macrophages. Engulfment of K.pneumoniae was dependent on host cytoskeleton, cell plasma membrane lipid rafts and the activation of phosphoinositide 3-kinase (PI3K). Microscopy studies revealed that K.pneumoniae resides within a vacuolar compartment, the Klebsiella-containing vacuole (KCV), which traffics within vacuoles associated with the endocytic pathway. In contrast to UV-killed bacteria, the majority of live bacteria did not co-localize with markers of the lysosomal compartment. Our data suggest that K.pneumoniae triggers a programmed cell death in macrophages displaying features of apoptosis. Our efforts to identify the mechanism(s) whereby K.pneumoniae prevents the fusion of the lysosomes to the KCV uncovered the central role of the PI3K-Akt-Rab14 axis to control the phagosome maturation. Our data revealed that the capsule is dispensable for Klebsiella intracellular survival if bacteria were not opsonized. Furthermore, the environment found by Klebsiella within the KCV triggered the down-regulation of the expression of cps. Altogether, this study proves evidence that K.pneumoniae survives killing by macrophages by manipulating phagosome maturation that may contribute to Klebsiella pathogenesis. Prevailing belief states that the human pathogens Klebsiella pneumoniae is an extracellular pathogen. However, in this work, we demonstrate that K. pneumoniae co-opts the maturation of the phagosome manipulating a PI3K-AKT-RAB14 signalling cascade. Here, we also demonstrate that by preventing the activation of this cascade, the macrophages eliminate intracellular Klebsiella. © 2015 John Wiley, M.I.M.-L. was financially supported by the Instituto de Salud Carlos III (grant CM09/000123). Part of this work was supported by grant PS09-00130 from Instituto de Salud Carlos III to J.G. and by grants from Biomedicine Program (SAF2009-07885 and SAF2012-39841), Ministerio de Economía y Competitividad (Spain), Govern Illes Balears (Competitive group Ref: 46/2011) and Queen's University Belfast start-up funds to J.A.B. This research was also supported by a Marie Curie FP7 Integration Grant (U-KARE; PCIG13-GA-2013-618162) to J.A.B. within the 7th European Union Framework Programme. CIBERES is an initiative from Instituto de Salud Carlos III.

Published
2015
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30. El compromiso ante el cambio climático desde nuestro territorio

Author

Iturrabarría, M., Aizpuru, I., Agut, A., Heras, P., Infante, M., Abrego, N., García, D., Herrera, M., Oloriaga, I., Salcedo, I., Sarrionandía, E., Garmendia, J., Oreja, L., Prieto, A., and Picón, R.

Subjects
Botánica, Cambio climático, Conservación de las plantas
Abstract

VII Congreso de Biología de Conservación de las Plantas Del 30 de septiembre al 2 de octubre de 2015 Sede central del Gobierno Vasco

Published
2015

32. Política editorial de Medicina Intensiva

Author

Leal-Noval, Santiago R., Amaya-Villar, Rosario, García-Garmendia, J. L., Gordo-Vidal, F., Garnacho-Montero, José, Leal-Noval, Santiago R., Amaya-Villar, Rosario, García-Garmendia, J. L., Gordo-Vidal, F., and Garnacho-Montero, José

Published
2017

33. Response of single benthic metrics and multi-metric methods to anthropogenic pressure gradients, in five distinct European coastal and transitional ecosystems

Author

Borja A., Barbone E., Borgersen G., Brkljacic M., Elliott M., Garmendia J. M., Marques J. C., Mazik K., Muxika I., Neto J. M., Norling K., Rodriguez J. G., Rosati I., Rygg B., Teixeira H., Trayanova A., BASSET, Alberto, Borja, A., Barbone, E., Basset, Alberto, Borgersen, G., Brkljacic, M., Elliott, M., Garmendia, J. M., Marques, J. C., Mazik, K., Muxika, I., Neto, J. M., Norling, K., Rodriguez, J. G., Rosati, I., Rygg, B., Teixeira, H., and Trayanova, A.

Abstract

In recent times many benthic indices have been proposed to assess the ecological quality of marine waters worldwide. In this study we compared single metrics and multi-metric methods to assess coastal and transitional benthic status along human pressure gradients in five distinct environments across Europe: Varna bay and lake (Bulgaria), Lesina lagoon (Italy), Mondego estuary (Portugal), Basque coast (Spain) and Oslofjord (Norway). Hence, 13 single metrics (abundance, number of taxa, and several diversity and sensitivity indices) and eight of the most common indices used within the European Water Framework Directive (WFD) for benthic assessment were selected: index of size spectra (ISS), Benthic assessment tool (BAT), Norwegian quality index (NQI), Multivariate AMBI (M-AMBI), Benthic quality index (BQI), (Benthic ecosystem quality index (BEQI), Benthic index based on taxonomic sufficiency (BITS), and infaunal quality index (IQI). Within each system, sampling sites were ordered in an increasing pressure gradient according to a preliminary classification based on professional judgement. The different indices are largely consistent in their response to pressure gradient, except in some particular cases (i.e. BITS, in all cases, or ISS when a low number of individuals is present). Inconsistencies between indicator responses were most pronounced in transitional waters (i.e. IQI, BEQI), highlighting the difficulties of the generic application of indicators to all marine, estuarine and lagoonal environments. However, some of the single (i.e. ecological groups approach, diversity, richness) and multi-metric methods (i.e. BAT, M-AMBI, NQI) were able to detect such gradients both in transitional and coastal environments, being these multi-metric methods more consistent in the detection than single indices. This study highlights the importance of survey design and good reference conditions for some indicators. The agreement observed between different methodologies and their ability to detect quality trends across distinct environments constitutes a promising result for the implementation of the WFD's monitoring plans. Moreover, these results have management implications, regarding the dangers of misclassification, uncertainty in the assessment, use of conflicting indices, and testing and validation of indices. © 2010 Elsevier Ltd.

Published
2011

35. Viscoelastic and Mechanical Properties of Epoxy/Mixed Amine Systems. Influence of Stoichiometry and Cure Conditions

Author

Garmendia, J., Alcorta, C., Rodrigo Llano-Ponte, Mondragon, I., and Rubio, A.

Subjects
Polymers and Plastics, Materials Chemistry, Ceramics and Composites
Abstract

Epoxy networks based on the diglycidyl ether of bisphenol A (DGEBA) and a mixture of an aliphatic triamine and a difunctional cycloaliphatic diamine were studied. The glass transition temperatures of mixtures with different stoichiometric ratios were analysed by differential scanning calorimetry and dynamic mechanical techniques. The influence of the cure schedule was also studied for all mixtures, post-cured and not fully cured. Differences in crosslink densities were studied in the glass transition region. By using the average molecular weight between crosslinks, calculated using the rubber elasticity theory, the correlation between the glass transition temperature of cured systems and that corresponding to the unreacted system was determined. The variation of the glass transition temperatures was interpreted in terms of the macromolecular chain motions. Flexural properties such as modulus, strength, and strain to break were measured for the post-cured mixtures with different stoichiometrics.

Published
1996
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36. New progress in modelling the response of a marine

Author

Caill-Milly, N., D'Amico, Frank, Guyader, Olivier, Bald Garmendia, J., Dang, C., Bru, Noëlle, Laboratoire de Mathématiques et de leurs Applications [Pau] (LMAP), Université de Pau et des Pays de l'Adour (UPPA)-Centre National de la Recherche Scientifique (CNRS), and Lma-Pau, Responsable Hal

Subjects
[MATH.MATH-PR]Mathematics [math]/Probability [math.PR], [MATH.MATH-PR] Mathematics [math]/Probability [math.PR], ComputingMilieux_MISCELLANEOUS
Abstract

COM; International audience; no abstract

Published
2012

38. Increased biofilm formation by nontypeable Haemophilus influenzae isolates from patients with invasive disease or otitis media versus strains recovered from cases of respiratory infections

Author

Puig, C., Domenech, A., Garmendia, J., Langereis, J.D., Mayer, P., Calatayud, L., Linares, J., Ardanuy, C., Marti, S., Puig, C., Domenech, A., Garmendia, J., Langereis, J.D., Mayer, P., Calatayud, L., Linares, J., Ardanuy, C., and Marti, S.

Abstract

Contains fulltext : 138899.pdf (publisher's version ) (Open Access), Biofilm formation by nontypeable (NT) Haemophilus influenzae remains a controversial topic. Nevertheless, biofilm-like structures have been observed in the middle-ear mucosa of experimental chinchilla models of otitis media (OM). To date, there have been no studies of biofilm formation in large collections of clinical isolates. This study aimed to investigate the initial adhesion to a solid surface and biofilm formation by NT H. influenzae by comparing isolates from healthy carriers, those with noninvasive respiratory disease, and those with invasive respiratory disease. We used 352 isolates from patients with nonbacteremic community-acquired pneumonia (NB-CAP), chronic obstructive pulmonary disease (COPD), OM, and invasive disease and a group of healthy colonized children. We then determined the speed of initial adhesion to a solid surface by the BioFilm ring test and quantified biofilm formation by crystal violet staining. Isolates from different clinical sources displayed high levels of biofilm formation on a static solid support after growth for 24 h. We observed clear differences in initial attachment and biofilm formation depending on the pathology associated with NT H. influenzae isolation, with significantly increased biofilm formation for NT H. influenzae isolates collected from patients with invasive disease and OM compared with NT H. influenzae isolates from patients with NB-CAP or COPD and healthy colonized subjects. In all cases, biofilm structures were detached by proteinase K treatment, suggesting an important role for proteins in the initial adhesion and static biofilm formation measured by crystal violet staining.

Published
2014

39. Pollen limitation may be a common Allee effect in marine hydrophilous plants: implications for decline and recovery in seagrasses.

Author

Tussenbroek, B., Soissons, L., Bouma, T., Asmus, R., Auby, I., Brun, F., Cardoso, P., Desroy, N., Fournier, J., Ganthy, F., Garmendia, J., Godet, L., Grilo, T., Kadel, P., Ondiviela, B., Peralta, G., Recio, M., Valle, M., Heide, T., and Katwijk, M.

Subjects
POLLEN, ALLEE effect, MARINE plants, FRAGMENTED landscapes, SEAGRASSES, PLANT ecology, INTERTIDAL ecology
Abstract

Pollen limitation may be an important factor in accelerated decline of sparse or fragmented populations. Little is known whether hydrophilous plants (pollen transport by water) suffer from an Allee effect due to pollen limitation or not. Hydrophilous pollination is a typical trait of marine angiosperms or seagrasses. Although seagrass flowers usually have high pollen production, floral densities are highly variable. We evaluated pollen limitation for intertidal populations of the seagrass Zostera noltei in The Netherlands and found a significant positive relation between flowering spathe density and fruit-set, which was suboptimal at <1200 flowering spathes m (corresponding to <600 reproductive shoots m). A fragmented population had ≈35 % lower fruit-set at similar reproductive density than a continuous population. 75 % of all European populations studied over a large latitudinal gradient had flowering spathe densities below that required for optimal fruit-set, particularly in Southern countries. Literature review of the reproductive output of hydrophilous pollinated plants revealed that seed- or fruit-set of marine hydrophilous plants is generally low, as compared to hydrophilous freshwater and wind-pollinated plants. We conclude that pollen limitation as found in Z. noltei may be a common Allee effect for seagrasses, potentially accelerating decline and impairing recovery even after environmental conditions have improved substantially. [ABSTRACT FROM AUTHOR]

Published
2016
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41. Miositis osificante progresiva: ultraestructura, bioquímica e histoquímica de músculo macroscópicamente sano

Author

Garmendia, J., Torres, S.H., Hernández, N., Finol, Héctor J., and Martínez Conde, A.

Subjects
Medicina clínica, UNESCO::CIENCIAS MÉDICAS, CIENCIAS MÉDICAS [UNESCO], Ciencias de la salud
Abstract

Se estudió un caso de miositis osificante progresiva en una niña de 13 años, a la cual se le tomó una muestra de músculo gastronecmio lateral, aparentemente no afectado, en el curso de una intervención quirúrgica ortopédica. La muestra se procesó mediante métodos histológicos, histoquímicos, bioquímicos, inmunocitoquímicos y ultraestructurales. Se encontró un predominio de fibras musculares tipo I (83%) con alta capacidad oxidativa y baja capacidad glicolítica. Las fibras del tipo II eran pequeñas (área promedio 2.084 Um2 ) y mostraron otros signos de atrofia al examen ultraestructural. La densidad capilar fue relativamente alta, (573) siendo normal el índice capilar/fibra (1,76). Sin embargo, algunos capilares se mostraron engrosados y con la luz ocluida, con la tinción de amilasa-PAS, lo cual fue corroborado con la microscopía electrónica, donde se vio la membrana basal engrosada, e inclusive algunos capilares totalmente degenerados. No se encontró reacción de inmunofluorescencia con las globulinas anti-IgG ni anti-IgM en los cortes de músculo. El espacio intersticial se encontró agrandado. Se concluye que no hay evidencias de la participación de un mecanismo autoinmune en la miositis osificante progresiva, que existe un daño capilar y alteración de las fibras musculares, aún en el músculo que no manifiesta a simple vista proceso de osificación. During an orthopedic operation a sample of the apparently normal lateral gastronecmius muscle was taken from a 13 year old female patient affected by myositis ossificans progressiva. The muscle sample was analyzed by light, electron and fluorescence microscopy, and some enzymes were assayed. Muscle fibers were classified by the adenosintriphosphatase reaction. The percentage of type I fiber was high (83%). Atrophy was found in type II fibers as shown by small mean area (2.084 Um2 ) and some ultrastructural features as infoldings of the sarcolemma. Capillary density was high (573 capillaries/mm2 ), and capillaries per fiber index was normal (1.76), as were oxidative enzymes. However many capillaries were occluded, with thick basal membrane and abnormal endothelial cells and pericytes. No immunofluorescence was found with anti IgG or anti IgM in the muscle fibers. Intersticial spaces in the cross section of the muscle were enlarged. In conclusion, no evidence of autoimmune involvement was found in myositis ossificans progressiva, but alteracions of capillaries and muscle fibers were found in a muscle apparently not affected yet by the ossification process.

Published
1995

42. Acute deterioration of bulbar function after ultrasound-guided botulinum toxin injection for the treatment of sialorrhoea in bulbar amyotrophic lateral sclerosis: a case report

Author

Fernandez-Barriales Lopez, M., primary, Saldaña, M., additional, Blasco, J., additional, López, D.P., additional, García-Reija, F., additional, García-Montesinos, B., additional, González Terán, T., additional, Sánchez Santolino, S., additional, Garmendia, J., additional, Ruiz de Temiño, C., additional, Lastra, P., additional, and Saiz Bustillo, R.C., additional

Published
2011
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43. Intramedullary curettage and three-dimensional surface modelling of zigomaticomaxillary fibrous dysplasia: a case report and review of current surgical techniques

Author

Fernandez-Barriales Lopez, M., primary, Saldaña, M., additional, Blasco, J., additional, Lopez, D.P., additional, García-Montesinos, B., additional, García-Reija, F., additional, González Terán, T., additional, Sánchez Santolino, S., additional, Garmendia, J., additional, Ruiz de Temiño, C., additional, and Saiz Bustillo, R.C., additional

Published
2011
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47. P.340 Plate-guided distractor for a segmental mandibular defect

Author

Garcia-Montesinos Perea, B., primary, Garcia Reija, M.F., additional, Vazquez Marcos, V., additional, Garcia Pire, F., additional, Rodriguez Caballero, B., additional, Herrera Calvo, G., additional, Saldaña, M., additional, Sanchez Santolino, S., additional, Gonzalez Terán, T., additional, Ruiz De Temiño, C., additional, Garmendia, J., additional, and Saiz Bustillo, R., additional

Published
2008
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50. Identification of an effector specificity subregion within the aromatic-responsive regulators DmpR and XylR by DNA shuffling.

Author

Skärfstad, E, O'Neill, E, Garmendia, J, Shingler, V, Skärfstad, E, O'Neill, E, Garmendia, J, and Shingler, V

Abstract

The Pseudomonas derived sigma(54)-dependent regulators DmpR and XylR control the expression of genes involved in catabolism of aromatic compounds. Binding to distinct, nonoverlapping groups of aromatic effectors controls the activities of these transcriptional activators. Previous work has derived a common mechanistic model for these two regulators in which effector binding by the N-terminal 210 residues (the A-domain) of the protein relieves repression of an intrinsic ATPase activity essential for its transcription-promoting property and allows productive interaction with the transcriptional apparatus. Here we dissect the A-domains of DmpR and XylR by DNA shuffling to identify the region(s) that mediates the differences in the effector specificity profiles. Analysis of in vivo transcription in response to multiple aromatic effectors and the in vitro phenol-binding abilities of regulator derivatives with hybrid DmpR/XylR A-domains reveals that residues 110 to 186 are key determinants that distinguish the effector profiles of DmpR and XylR. Moreover, the properties of some mosaic DmpR/XylR derivatives reveal that high-affinity aromatic effector binding can be completely uncoupled from the ability to promote transcription. Hence, novel aromatic binding properties will only be translated into functional transcriptional activation if effector binding also triggers release of interdomain repression.

Published
2000

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