388 results on '"Garte, S."'
Search Results
2. Theory in Carcinogenesis and Epidemiology
- Author
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Garte, S.
- Published
- 2003
3. Effect of vitamin levels on biomarkers of exposure and oxidative damage—The EXPAH study
- Author
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Sram, R.J., Farmer, P., Singh, R., Garte, S., Kalina, I., Popov, T.A., Binkova, B., Ragin, C., and Taioli, E.
- Published
- 2009
- Full Text
- View/download PDF
4. Genetic susceptibility according to three metabolic pathways in cancers of the lung and bladder and in myeloid leukemias in nonsmokers
- Author
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Vineis, P., Veglia, F., Garte, S., Malaveille, C., Matullo, G., Dunning, A., Peluso, M., Airoldi, L., Overvad, K., Raaschou-Nielsen, O., Clavel-Chapelon, F., Linseisen, J. P., Kaaks, R., Boeing, H., Trichopoulou, A., Palli, D., Crosignani, P., Tumino, R., Panico, S., Bueno-De-Mesquita, H. B., Peeters, P. H., Lund, E., Gonzalez, C. A., Martinez, C., Dorronsoro, M., Barricarte, A., Navarro, C., Quiros, J. R., Berglund, G., Jarvholm, B., Day, N. E., Key, T. J., Saracci, R., Riboli, E., and Autrup, H.
- Published
- 2007
5. Multi-factor dimensionality reduction applied to a large prospective investigation on gene–gene and gene–environment interactions
- Author
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Manuguerra, M., Matullo, G., Veglia, F., Autrup, H., Dunning, A.M., Garte, S., Gormally, E., Malaveille, C., Guarrera, S., Polidoro, S., Saletta, F., Peluso, M., Airoldi, L., Overvad, K., Raaschou-Nielsen, O., Clavel-Chapelon, F., Linseisen, J., Boeing, H., Trichopoulos, D., Kalandidi, A., Palli, D., Krogh, V., Tumino, R., Panico, S., Bueno-De-Mesquita, H.B., Peeters, P.H., Lund, E., Pera, G., Martinez, C., Amiano, P., Barricarte, A., Tormo, M.J., Quiros, J.R., Berglund, G., Janzon, L., Jarvholm, B., Day, N.E., Allen, N.E., Saracci, R., Kaaks, R., Ferrari, P., Riboli, E., and Vineis, P.
- Published
- 2007
6. Meta- and Pooled Analysis of GSTT1 and Lung Cancer: A HuGE-GSEC Review
- Author
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Raimondi, S., Paracchini, V., Autrup, H., Barros-Dios, J. M., Benhamou, S., Boffetta, P., Cote, M. L., Dialyna, I. A., Dolzan, V., Filiberti, R., Garte, S., Hirvonen, A., Husgafvel-Pursiainen, K., Imyanitov, E. N., Kalina, I., Kang, D., Kiyohara, C., Kohno, T., Kremers, P., Lan, Q., London, S., Povey, A. C., Rannug, A., Reszka, E., Risch, A., Romkes, M., Schneider, J., Seow, A., Shields, P. G., Sobti, R. C., Sørensen, M., Spinola, M., Spitz, M. R., Strange, R. C., Stücker, I., Sugimura, H., To-Figueras, J., Tokudome, S., Yang, P., Yuan, J-M., Warholm, M., and Taioli, E.
- Published
- 2006
7. DNA repair polymorphisms and cancer risk in non-smokers in a cohort study
- Author
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Matullo, G., Dunning, A.M., Guarrera, S., Baynes, C., Polidoro, S., Garte, S., Autrup, H., Malaveille, C., Peluso, M., Airoldi, L., Veglia, F., Gormally, E., Hoek, G., Krzyzanowski, M., Overvad, K., Raaschou-Nielsen, O., Clavel-Chapelon, F., Linseisen, J., Boeing, H., Trichopoulou, A., Palli, D., Krogh, V., Tumino, R., Panico, S., Bueno-De-Mesquita, H.B., Peeters, P.H., Lund, E., Pera, G., Martinez, C., Dorronsoro, M., Barricarte, A., Tormo, M.J., Quiros, J.R., Day, N.E., Key, T.J., Saracci, R., Kaaks, R., Riboli, E., and Vineis, P.
- Published
- 2006
8. Environmental tobacco smoke and risk of respiratory cancer and chronic obstructive pulmonary disease in former smokers and never smokers in the EPIC prospective study
- Author
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Vineis, P, Airoldi, L, Veglia, P, Olgiati, L, Pastorelli, R, Autrup, H, Dunning, A, Garte, S, Gormally, E, Hainaut, P, Malaveille, C, Matullo, G, Peluso, M, Overvad, K, Tjonneland, A, Clavel-Chapelon, F, Boeing, H, Krogh, V, Palli, D, Panico, S, Tumino, R, Bueno-De-Mesquita, B, Peeters, P, Berglund, G, Hallmans, G, Saracci, R, and Riboli, E
- Published
- 2005
9. Association of metabolic gene polymorphisms with alcohol consumption in controls
- Author
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Raimondi, S., Benhamou, S., Coutelle, C., Garte, S., Hayes, R., Kiemeney, L., Lazarus, P., Marchand, L. LE, Morita, S., Povey, A., Romkes, M., Zijno, A., and Taioli, E.
- Published
- 2004
10. Supplement II: Abstracts of the international symposium on Skin Carcinogenesis in man and in experimental models. Heidelberg, 29–31 October 1991 (pp S61–S88)
- Author
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Barrett, J. C., Afshari, C. A., Annab, L. A., Burkhart, B. A., Boyd, J. A., Owen, R. D., Futreal, P. A., Richter, K. H., Moses, H. L., Lavker, R. M., Miller, Stanley, Sun, T. -T., Stingl, G., Bianchi, A. B., Navone, N. M., Conti, C. J., Spencer, James M., Kahn, S., Weinstein, I. B., Silvers, D. S., DeLeo, V. A., Larcher, F., Bauluz, C., Quintanilla, M., Ballestin, C., Jorcano, J. L., Schön, M., Haas, M., Klein, C. E., Weber, L., Cerri, A., Tadini, G., Gitto, R., Berti, E., Cano, A., Caulín, C., Gómez, M., Gandarillas, A., Martín, M., Montes, A., Navarro, P., Bastian, B. C., Van der Piepen, U., Römisch, J., Pâques, E., Hartmann, A. A., Krieg, P., Schnapke, R., Feil, S., Fürstenberger, G., Marks, F., Missero, C., Cajal, S. Ramon y, Filvaroff, E., Dotto, G. P., Sherman, J., Albert, R. E., Baxter, C. S., Bauer, G., Höfler, P., Götschl, M., Viesel, E., Jürgensmeier, J., Schaefer, D., Picht, G., Grande, T., Real, A., Rünqer, T. M., Möller, K., Fuchs, P., Bauer, C., Epe' B., Gruner, S., Diezel, W., Macejewski, J., Weber, H., Eckert, R., Volk, H. D., Sönnichsen, N., Bavinck, Jan N. Bouwes, Vermeer, Bert J., Van Der Woude, Fokko J., Vandenbroucke, Jan P., Claas, Frans H. J., Griffin, E. F., Harris, H., Tilgen, W., Garbe, C., Østerlind, Anne, Weiss, J., Jung, E. G., Ruiter, D. J., Danen, E., Broecker, E. -B., Johnson, J. P., van Muijen, G. N. P., Halaban, R., Krüger-Krasagakes, S., Orfanos, C. E., Newton, J. A., Bataille, V., Cuzick, J., Bishop, T., Schwaaf, A., Azizi, E., Bröcker, E. B., Eberlein, B., Froschermaier, S., Gollhausen, R., Przybilla, B., Krasagakis, K., Abdel-Naser, M. B., Lopez-Bran, E., Robledo, A., Lopez-Bran, E., Heine, H., Hennig, B., Graf, G., Nährig, J., Niedner, R., Schöpf, E., Mailhammer, R., Reisbach, G., Kempkes, B., Hültner, L., Thalmeier, K., Anders, F., Zechel, C., Schleenbecker, U., Leers, J., Smith, A., Wagner, E., Burcin, U., Hug, H., Fiebich, B., Anders, A., Gröger, H., Schlatterer, B., Moll, I., Wollina, U., Leigh IM, Purkis PE, Markey A., Neill S., Proby C., Glover M., Lane EB, Klein-Szanto, A. J. P., Yaar, M., Garmyn, M., Gilani, A., Gilchrest, B. A., Bowden, G. T., Nelson, M., Levy, J., Tanooka, Hiroshi, Ootsuyama, Akira, Urbach, F., van der Leun, J. C., de Gruijl, F. R., Kripke, Margaret L., Yuspa, S. H., Glick, A., Lee, E., Diugosz, A., Balmain, A., Bums, P., Kemp, C. J., Stoler, A. B., Harks, F., Boukamp, P., Pascheberg, U., Breitkreutz, D., Hülsen, A., Altmeier, S., Tomakidi, P., Fusenig, N. E., Lowy, Douglas R., Sedman, Sylvia A., Cohen, Bruce D., Schiller, John T., Kricker, A., Armstrong, B. K., English, D., Heenan, P. J., Randell, P. L., de Gruijl, F. R., Kelfkens, G., van Weelden, H., van der Leun, J. C., Grabbe, S., Bruvers, S., Granstein, R. D., Albert, R., Miller, M., Cody, T., Baxter, C., Shukla, R., Ueda, M., Ichihashi, M., Yamamura, K., Hayashibe, K., Funasaka, Y., Mishima, Y., Fujiwara, Y., Ichihashi, M., Jimbo, T., Mishima, Y., Popanda, O., Thielmann, H. W., Jahrens, D., Edler, L., Ootsuyama, A., Tanooka, H., Sutter, C., Mukhtar, H., Strickland, P. T., Winter, H., Schweizer, J., Schmidt, R., Weber, E., Rippmann, F., Hecker, E., Kopp-Schneider, A., Lehmann, W. D., Stephan, M., Troll, W., Wei, H., Fujiki, H., Garte, S. J., Frenkel, K., Svetek, J., Schara, M., Pečar, S., Hergenhahn, M., Kinzel, V., Richards, J., Plein, P., Schiess, K., Kaszkin, M., Yamamoto, S., Wang, J. C., Kato, R., Kuroki, T., Hashimoto, Y., Osada, S., Ohno, S., Gilles, C., Piette, M., Foidart, J. -M., Ranki, A., Lassus, J., Lehmus, A., Niemi, K. -M., Friesel, H., Schneider, T., Steinbauer, B., Sorg, B., Winter, A., Krauter, G., Krauß, R., Roeser, H., Unger, Sylvia, Janiaud, Paul, Rueß, Doris, Mechler, Bernard M., Stanbridge, Eric J., Gross, Monika M., Buček, M., Klein-Bauernschmitt, P., Schlehofer, J. R., Kosters, R., Stark, H. -J., Okulov, V. B., Elgjo, K., Ushmorov, A. G., Danilov, A. O., Zubova, S. G., Furstenberger, G., and Faissner, A.
- Published
- 1991
- Full Text
- View/download PDF
11. Metabolic gene polymorphisms and p53 mutations in healthy centenarians and younger controls
- Author
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GASPARI, L., PEDOTTI, P., BONAFÈ, M., FRANCESCHI, C., MARINELLI, D., MARI, D., GARTE, S., and TAIOLI, E.
- Published
- 2003
12. Polymorphisms in CYP1A1, GSTM1, GSTT1 and lung cancer below the age of 45 years
- Author
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Taioli, E, Gaspari, L, Benhamou, S, Boffetta, P, Brockmoller, J, Butkiewicz, D, Cascorbi, I, Clapper, ML, Dolzan, V, Haugen, A, Hirvonen, A, Husgafvel-Pursiainen, K, Kalina, I, Kremers, P, Le Marchand, L, London, S, Rannug, A, Romkes, M, Schoket, B, Seidegard, J, Strange, RC, Stucker, I, To-Figueras, J, and Garte, S
- Published
- 2003
13. Genotype Components as Predictors of Phenotype in Model Gene Regulatory Networks
- Author
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Garte, S., primary and Albert, A., additional
- Published
- 2019
- Full Text
- View/download PDF
14. Oncogenes Activated in Radiation-Induced Rat Skin Tumors
- Author
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Garte, S. J., Sawey, M. J., Burns, F. J., Burns, F. J., editor, Upton, A. C., editor, and Silini, G., editor
- Published
- 1986
- Full Text
- View/download PDF
15. Meat intake and bladder cancer in a prospective study: A role for heterocyclic aromatic amines? (Cancer Causes and Control DOI: 10.1007/s10552-008-9121-1)
- Author
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Lumbreras, B, Garte, S, Overvad, K, Tjonneland, A, Clavel-Chapelon, F, Linseisen, J, Boeing, H, Trichopoulou, A, Palli, D, Peluso, M, Krogh, V, Tumino, R, Panico, S, Bueno-De-Mesquita, H, Peeters, P, Lund, E, Martinez, C, Dorronsoro, M, Barricarte, A, Chirlaque, MD, Quiros, JR, Berglund, G, Hallmans, G, Day, N, and Key, T
- Published
- 2016
16. Quantitative analysis of DNA methylation after whole bisulfitome amplification of a minute amount of DNA from body fluids
- Author
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Thomas Vaissière, Cyrille Cuenin, Anupam Paliwal, Paolo Vineis, Hoek, G., Krzyzanowski, M., Airoldi, L., Dunning, A., Garte, S., Hainaut, P., Malaveille, C., Kim Overvad, Clavel-Chapelon, F., Linseisen, J., Boeing, H., Trichopoulou, A., Trichopoulos, D., Kaladidi, A., Palli, D., Krogh, V., Tumino, R., Panico, S., Hb Bueno-De-Mesquita, Ph Peeters, Kumle, M., Ca Gonzalez, Martinez, C., Dorronsoro, M., Barricarte, A., Navarro, C., Jr Quiros, Berglund, G., Janzon, L., Jarvholm, B., Ne Day, Tj Key, Saracci, R., Kaaks, R., Riboli, E., Pierre Hainaut, Zdenko Herceg, Vaissière, T, Cuenin, C, Paliwal, A, Vineis, P, Hoek, G, Krzyzanowski, M, Airoldi, L, Dunning, A, Garte, S, Hainaut, P, Malaveille, C, Overvad, K, Clavel Chapelon, F, Linseisen, J, Boeing, H, Trichopoulou, A, Trichopoulos, D, Kaladidi, A, Palli, D, Krogh, V, Tumino, R, Panico, Salvatore, Bueno De Mesquita, Hb, Peeters, Ph, Kumle, M, Gonzalez, Ca, Martinez, C, Dorronsoro, M, Barricarte, A, Navarro, C, Quiros, Jr, Berglund, G, Janzon, L, Jarvholm, B, Day, Ne, Key, Tj, Saracci, R, Kaaks, R, Riboli, E, Herceg, Z., Risk Assessment of Toxic and Immunomodulatory Agents, and Dep IRAS
- Subjects
Cancer Research ,Lung Neoplasms ,Computational biology ,Biology ,chemistry.chemical_compound ,Humans ,Methylated DNA immunoprecipitation ,Biomarker discovery ,Promoter Regions, Genetic ,Molecular Biology ,Methylenetetrahydrofolate Reductase (NADPH2) ,Adaptor Proteins, Signal Transducing ,Genome, Human ,Genes, p16 ,Tumor Suppressor Proteins ,Multiple displacement amplification ,Nuclear Proteins ,Methylation ,DNA Methylation ,Molecular biology ,Body Fluids ,Long Interspersed Nucleotide Elements ,chemistry ,DNA methylation ,Pyrosequencing ,Illumina Methylation Assay ,CpG Islands ,MutL Protein Homolog 1 ,Nucleic Acid Amplification Techniques ,DNA - Abstract
Udgivelsesdato: 2009-May-24 Cell-free circulating DNA isolated from the plasma of individuals with cancer has been shown to harbor cancer-associated changes in DNA methylation, and thus it represents an attractive target for biomarker discovery. However, the reliable detection of DNA methylation changes in body fluids has proven to be technically challenging. Here we describe a novel combination of methods that allows quantitative and sensitive detection of DNA methylation in minute amounts of DNA present in body fluids (quantitative Methylation Analysis of Minute DNA amounts after whole Bisulfitome Amplification, qMAMBA). This method involves genome-wide amplification of bisulphite-modified DNA template followed by quantitative methylation detection using pyrosequencing and allows analysis of multiple genes from a small amount of starting DNA. To validate our method we used qMAMBA assays for four genes and LINE1 repetitive sequences combined with plasma DNA samples as a model system. qMAMBA offered high efficacy in the analysis of methylation levels and patterns in plasma samples with extremely small amounts of DNA and low concentrations of methylated alleles. Therefore, qMAMBA will facilitate methylation studies aiming to discover epigenetic biomarkers, and should prove particularly valuable in profiling a large sample series of body fluids from molecular epidemiology studies as well as in tracking disease in early diagnostics.
- Published
- 2009
17. Erratum: Amount of DNA in plasma and cancer risk: A prospective study (International Journal of Cancer (2004) 111 (746-749))
- Author
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Gormally, E., Hainaut, P., Caboux, E., Airoldi, L., Autrup, H., Malaveille, C., Dunning, A., Garte, S., Matullo, G., Overvad, K., Tjonneland, A., Clavel-Chapelon, F., Boffetta, P., Boeing, H., Trichopoulou, A., Palli, D., Krogh, V., Tumino, R., Panico, S., Bueno-De-Mesquita, H. B., Peeters, P. H., Lund, E., Gonzalez, C. A., Martinez, C., Dorronsoro, M., Barricarte, A., Tormo, M. J., Quiros, J. R., Berglund, G., Hallmans, G., Day, N. E., Key, T. J., Veglia, F., Peluso, M., Norat, T., Saracci, R., Kaaks, R., Riboli, E., Vineis, P., Gormally, E., Hainaut, P., Caboux, E., Airoldi, L., Autrup, H., Malaveille, C., Dunning, A., Garte, S., Matullo, G., Overvad, K., Tjonneland, A., Clavel-Chapelon, F., Boffetta, P., Boeing, H., Trichopoulou, A., Palli, D., Krogh, V., Tumino, R., Panico, S., Bueno-De-Mesquita, H.B., Peeters, P.H., Lund, E., Gonzalez, C.A., Martinez, C., Dorronsoro, M., Barricarte, A., Tormo, M.J., Quiros, J.R., Berglund, G., Hallmans, G., Day, N.E., Key, T.J., Veglia, F., Peluso, M., Norat, T., Saracci, R., Kaaks, R., Riboli, E., and Vineis, P.
- Subjects
Amount of DNA in plasma and cancer risk - Abstract
No abstract
- Published
- 2006
18. Biomarkers of dietary intake of micronutrientsmodulate DNA adduct levels in healthy adults
- Author
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Palli, D, Masala, G, Vineis, P, Garte, S, Saieva, C, Krogh, V, Tumino, R, Munnia, A, Riboli, E, Peluso, M., PANICO, SALVATORE, Palli, D, Masala, G, Vineis, P, Garte, S, Saieva, C, Krogh, V, Panico, Salvatore, Tumino, R, Munnia, A, Riboli, E, and Peluso, M.
- Published
- 2003
19. Biomarkers of dietary intake of micronutrients modulate DNA adduct levels in healthy adults. Carcinogenesis. 2003 Apr;24(4):739-46
- Author
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PALLI D., MASALA G., VINEIS P., GARTE S., SAIEVA C., KROGH V., TUMINO R., MUNNIA A., RIBOLI E., PELUSO M., PANICO, SALVATORE, Palli, D., Masala, G., Vineis, P., Garte, S., Saieva, C., Krogh, V., Panico, Salvatore, Tumino, R., Munnia, A., Riboli, E., and Peluso, M.
- Published
- 2003
20. Establishment of a rat nasal epithelial tumor celline
- Author
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Hood, A. T., Currie, D., and Garte, S. J.
- Published
- 1987
- Full Text
- View/download PDF
21. Diet, metabolic polymorphisms and dna adducts: the EPIC-Italy cross-sectional study
- Author
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PALLI D., VINEIS P., RUSSO A., BERRINO F., KROGH V., MASALA G., MUNNIA A., TAIOLI E., TUMINO R., GARTE S., PELUSO M., PANICO, SALVATORE, Palli, D., Vineis, P., Russo, A., Berrino, F., Krogh, V., Masala, G., Munnia, A., Panico, Salvatore, Taioli, E., Tumino, R., Garte, S., and Peluso, M.
- Published
- 2000
22. Quantitative analysis of DNA methylation after whole bisulfitome amplification of a minute amount of DNA from body fluids
- Author
-
Vaissiere, T., Cuenin, C., Paliwal, A., Vineis, P., Hoek, G., Krzyzanowski, M., Airoldi, L., Dunning, A., Garte, S., Malaveille, C., Overvad, K., Clavel-Chapelon, F., Linseisen, J., Boeing, H., Trichopoulou, A., Trichopoulous, D., Kaladidi, A., Palli, D., Krogh, V., Tumino, R., Panico, S., Bueno de Mesquita, H.B., Peeters, P.H.M., Kumle, M., Gonzalez, C.A., Martinez, C., Dorronsoro, M., Barricarte, A., Navarro, C., Quiros, J.R., Berglund, B., Janzon, L., Jarvholm, B., Day, N.E., Key, T.J., Saracci, R., Kaaks, R., Riboli, E., Hainaut, P., Herceg, Z., Risk Assessment of Toxic and Immunomodulatory Agents, and Dep IRAS
- Abstract
Cell-free circulating DNA isolated from the plasma of individuals with cancer has been shown to harbor cancer-associated changes in DNA methylation, and thus it represents an attractive target for biomarker discovery. However, the reliable detection of DNA methylation changes in body fluids has proven to be technically challenging. Here we describe a novel combination of methods that allows quantitative and sensitive detection of DNA methylation in minute amounts of DNA present in body fluids (quantitative Methylation Analysis of Minute DNA amounts after whole Bisulfitome Amplification, qMAMBA). This method involves genome-wide amplification of bisulphite-modified DNA template followed by quantitative methylation detection using pyrosequencing and allows analysis of multiple genes from a small amount of starting DNA. To validate our method we used qMAMBA assays for four genes and LINE1 repetitive sequences combined with plasma DNA samples as a model system. qMAMBA offered high efficacy in the analysis of methylation levels and patterns in plasma samples with extremely small amounts of DNA and low concentrations of methylated alleles. Therefore, qMAMBA will facilitate methylation studies aiming to discover epigenetic biomarkers, and should prove particularly valuable in profiling a large sample series of body fluids from molecular epidemiology studies as well as in tracking disease in early diagnostics.
- Published
- 2009
23. Meat intake and bladder cancer in a prospective study: A role for heterocyclic aromatic amines?
- Author
-
Lumbreras, B. Garte, S. Overvad, K. Tjonneland, A. Clavel-Chapelon, F. Linseisen, J.P. Boeing, H. Trichopoulou, A. Palli, D. Peluso, M. Krogh, V. Tumino, R. Panico, S. Bueno-De-Mesquita, H.B. Peeters, P.H. Lund, E. Martinez, C. Dorronsoro, M. Barricarte, A. Chirlaque, M.-D. Quiros, J.R. Berglund, G. Hallmans, G. Day, N.E. Key, T.J. Saracci, R. Kaaks, R. Malaveille, C. Ferrari, P. Boffetta, P. Norat, T. Riboli, E. Gonzalez, C.A. Vineis, P.
- Abstract
Background: The suspect carcinogens, heterocyclic amines (HAAs), found in well-done meat require host-mediated metabolic activation before inducing DNA mutations. The role of SULT1A1 and of NAT2 on the activation of HAAs suggests that NAT2 rapid acetylator genotype and SULT1A1 allele variants can have an effect on HAA carcinogenicity. Methods: Data were collected as part of a case-control study nested within the EPIC cohort, the Gen Air investigation. EPIC is a prospective study designed to investigate the relationship between nutrition and cancer. Information was collected through a non-dietary questionnaire on lifestyle variables and through a dietary questionnaire. The subjects were restricted to non-smokers. We calculated the matched odds ratio for bladder cancer risk using logistic regression, controlling for potential confounders. Results: There were 227 bladder cases and 612 controls matched 1:3. Meat intake and NAT2 genotype were not independently associated with bladder cancer risk. A significant relationship was observed between bladder cancer risk and consumption of meat only among subjects with the rapid NAT2 genotype (odds ratios [OR] 2.9, 95% CI 1.0-7.9 for the 2nd quartile of meat intake; 3.6, 95% CI 1.3-9.7 for the 3rd quartile; and 3.5, 95% CI 1.2-9.7 for the 4th quartile), and was not present among subjects with the slow genotype. An interaction between NAT2 and meat intake was found in logistic regression (P = 0.034). No association was observed for SULT1A*1/2 genotype (1.0; 95% CI 0.7-1.5) and for SULT1A1*2/2 genotype (0.9; 95% CI 0.5-1.7). Conclusions: These results are suggestive of a role of meat intake and NAT2 on bladder cancer risk. They support the hypothesis that among subjects with the rapid NAT2 acetylation genotype higher levels of HAAs exposure are a bladder cancer risk factor. We did not observe an effect of SULT1A1 allele variants on this cancer. The present study adds new information on the possible long-term adverse effects of diets with high meat intake. © 2008 Springer Science+Business Media B.V.
- Published
- 2008
24. Meat intake and bladder cancer in a prospective study: A role for heterocyclic aromatic amines? (Cancer Causes and Control DOI: 10.1007/s10552-008-9121-1)
- Author
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Lumbreras, B. Garte, S. Overvad, K. Tjonneland, A. Clavel-Chapelon, F. Linseisen, J.P. Boeing, H. Trichopoulou, A. Palli, D. Peluso, M. Krogh, V. Tumino, R. Panico, S. Bueno-De-Mesquita, H.B. Peeters, P.H. Lund, E. Martinez, C. Dorronsoro, M. Barricarte, A. Chirlaque, M.D. Quiros, J.R. Berglund, G. Hallmans, G. Day, N.E. Key, T.J. Saracci, R. Kaaks, R. Malaveille, C. Ferrari, P. Boffetta, P. Norat, T. Riboli, E. Gonzalez, C.A. Vineis, P.
- Published
- 2008
25. Bulky DNA adducts, 4-aminobiphenyl-haemoglobin adducts and diet in the European Prospective Investigation into Cancer and Nutrition (EPIC) prospective study
- Author
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Peluso, M. Airoldi, L. Munnia, A. Colombi, A. Veglia, F. Autrup, H. Dunning, A. Garte, S. Gormally, E. Malaveille, C. Matullo, G. Overvad, K. Raaschou-Nielsen, O. Clavel-Chapelon, F. Linseisen, J. Boeing, H. Trichopoulou, A. Palli, D. Krogh, V. Tumino, R. Panico, S. Bueno-De-Mesquita, B.H. Peeters, P.H. Kumle, M. Agudo, A. Martinez, C. Dorronsoro, M. Barricarte, A. Tormo, M.J. Quiros, J.R. Berglund, G. Jarvholm, B. Day, N.E. Key, T.J. Saracci, R. Kaaks, R. Riboli, E. Bingham, S. Vineis, P.
- Abstract
In contrast to some extensively examined food mutagens, for example, aflatoxins, N-nitrosamines and heterocyclic amines, some other food contaminants, in particular polycyclic aromatic hydrocarbons (PAH) and other aromatic compounds, have received less attention. Therefore, exploring the relationships between dietary habits and the levels of biomarkers related to exposure to aromatic compounds is highly relevant. We have investigated in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort the association between dietary items (food groups and nutrients) and aromatic DNA adducts and 4-aminobiphenyl-Hb adducts. Both types of adducts are biomarkers of carcinogen exposure and possibly of cancer risk, and were measured, respectively, in leucocytes and erythrocytes of 1086 (DNA adducts) and 190 (Hb adducts) non-smokers. An inverse, statistically significant, association has been found between DNA adduct levels and dietary fibre intake (P=0.02), vitamin E (P=0.04) and alcohol (P=0.03) but not with other nutrients or food groups. Also, an inverse association between fibre and fruit intake, and BMI and 4-aminobiphenyl-Hb adducts (P=0.03, 0.04, and 0.03 respectively) was observed. After multivariate regression analysis these inverse correlations remained statistically significant, except for the correlation adducts v. fruit intake. The present study suggests that fibre intake in the usual range can modify the level of DNA or Hb aromatic adducts, but such role seems to be quantitatively modest. Fibres could reduce the formation of DNA adducts in different manners, by diluting potential food mutagens and carcinogens in the gastrointestinal tract, by speeding their transit through the colon and by binding carcinogenic substances.
- Published
- 2008
26. Multi-factor dimensionality reduction applied to a large prospective investigation on gene-gene and gene-environment interactions
- Author
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Manuguerra, M. Matullo, G. Veglia, F. Autrup, H. and Dunning, A. M. Garte, S. Gormally, E. Malaveille, C. and Guarrera, S. Polidoro, S. Saletta, F. Peluso, M. and Airoldi, L. Overvad, K. Raaschou-Nielsen, O. and Clavel-Chapelon, F. Linseisen, J. Boeing, H. Trichopoulos, D. Kalandidi, A. Palli, D. Krogh, V. Tumino, R. and Panico, S. Bueno-De-Mesquita, H. B. Peeters, P. H. Lund, E. and Pera, G. Martinez, C. Amiano, P. Barricarte, A. and Tormo, M. J. Quiros, J. R. Berglund, G. Janzon, L. and Jarvholm, B. Day, N. E. Allen, N. E. Saracci, R. Kaaks, R. Ferrari, P. Riboli, E. Vineis, P.
- Abstract
It is becoming increasingly evident that single-locus effects cannot explain complex multifactorial human diseases like cancer. We applied the multi-factor dimensionality reduction (MDR) method to a large cohort study on gene-environment and gene-gene interactions. The study (case-control nested in the EPIC cohort) was established to investigate molecular changes and genetic susceptibility in relation to air pollution and environmental tobacco smoke (ETS) in non-smokers. We have analyzed 757 controls and 409 cases with bladder cancer (n = 124), lung cancer (n = 116) and myeloid leukemia (n = 169). Thirty-six gene variants (DNA repair and metabolic genes) and three environmental exposure variables (measures of air pollution and ETS at home and at work) were analyzed. Interactions were assessed by prediction error percentage and cross-validation consistency (CVC) frequency. For lung cancer, the best model was given by a significant gene-environment association between the base excision repair (BER) XRCC1-Arg399Gln polymorphism, the double-strand break repair (DSBR) BRCA2-Asn372His polymorphism and the exposure variable ‘distance from heavy traffic road’, an indirect and robust indicator of air pollution (mean prediction error of 26%, P < 0.001, mean CVC of 6.60, P = 0.02). For bladder cancer, we found a significant 4-loci association between the BER APE1-Asp148Glu polymorphism, the DSBR RAD52-3’-untranslated region (3’-UTR) polymorphism and the metabolic gene polymorphisms COMT-Val158Met and MTHFR-677C > T (mean prediction error of 22%, P < 0.001, mean CVC consistency of 7.40, P < 0.037). For leukemia, a 3-loci model including RAD52-2259C > T, MnSOD-Ala9Val and CYP1A1-Ile462Val had a minimum prediction error of 31% (P < 0.001) and a maximum CVC of 4.40 (P = 0.086). The MDR method seems promising, because it provides a limited number of statistically stable interactions; however, the biological interpretation remains to be understood.
- Published
- 2007
27. Genetic susceptibility according to three metabolic pathways in cancers of the lung and bladder and in myeloid leukemias in nonsmokers
- Author
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Vineis, P. Veglia, F. Garte, S. Malaveille, C. Matullo, G. Dunning, A. Peluso, M. Airoldi, L. Overvad, K. Raaschou-Nielsen, O. Clavel-Chapelon, F. Linseisen, J.P. Kaaks, R. Boeing, H. Trichopoulou, A. Palli, D. Crosignani, P. Tumino, R. Panico, S. Bueno-De-Mesquita, H.B. Peeters, P.H. Lund, E. Gonzalez, C.A. Martinez, C. Dorronsoro, M. Barricarte, A. Navarro, C. Quiros, J.R. Berglund, G. Jarvholm, B. Day, N.E. Key, T.J. Saracci, R. Riboli, E. Autrup, H.
- Abstract
Background: We chose a set of candidate single nucleotide polymorphisms (SNPs) to investigate gene-environment interactions in three types of cancer that have been related to air pollution (lung, bladder and myeloid leukemia). Patients and methods: The study has been conducted as a nested case-control study within the European Prospective Investigation into Cancer and Nutrition cohort (409 cancer cases and 757 matched controls). We included never and ex-smokers. SNPs were in genes involved in oxidative stress, phase I metabolizing genes, phase II metabolizing genes and methylenetetrahydrofolate reductase (MTHFR). Results: The most notable findings are: GSTM1 deletion and bladder cancer risk [odds ratio (OR) = 1.60; 95% confidence interval 1.00-2.56]; CYP1A1 and leukemia (2.22, 1.33-3.70; heterozygotes); CYP1B1 and leukemia (0.47, 0.27-0.84; homozygotes); MnSOD and leukemia (1.91, 1.08-3.38; homozygotes) and NQO1 and lung cancer (8.03, 1.73-37.3; homozygotes). Other statistically significant associations were found in subgroups defined by smoking habits (never or ex-smokers), environmental tobacco smoke or gender, with no obvious pattern. When gene variants were organized according to the three main pathways, the emerging picture was of a strong involvement of combined phase I enzymes in leukemia, with an OR of 5 (1.63-15.4) for those having three or more variant alleles. The association was considerably stronger for leukemias arising before the age of 55. © 2007 European Society for Medical Oncology.
- Published
- 2007
28. DNA repair polymorphisms and cancer risk in non-smokers in a cohort study
- Author
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Matullo, G. Dunning, A.M. Guarrera, S. Baynes, C. Polidoro, S. Garte, S. Autrup, H. Malaveille, C. Peluso, M. Airoldi, L. Veglia, F. Gormally, E. Hoek, G. Krzyzanowski, M. Overvad, K. Raaschou-Nielsen, O. Clavel-Chapelon, F. Linseisen, J. Boeing, H. Trichopoulou, A. Palli, D. Krogh, V. Tumino, R. Panico, S. Bueno-De-Mesquita, H.B. Peeters, P.H. Lund, E. Pera, G. Martinez, C. Dorronsoro, M. Barricarte, A. Tormo, M.J. Quiros, J.R. Day, N.E. Key, T.J. Saracci, R. Kaaks, R. Riboli, E. Vineis, P.
- Abstract
Environmental carcinogens contained in air pollution, such as polycyclic aromatic hydrocarbons, aromatic amines or N-nitroso compounds, predominantly form DNA adducts but can also generate interstrand cross-links and reactive oxygen species. If unrepaired, such lesions increase the risk of somatic mutations and cancer. Our study investigated the relationships between 22 polymorphisms (and their haplotypes) in 16 DNA repair genes belonging to different repair pathways in 1094 controls and 567 cancer cases (bladder cancer, 131; lung cancer, 134; oral-pharyngeal cancer, 41; laryngeal cancer, 47; leukaemia, 179; death from emphysema and chronic obstructive pulmonary disease, 84). The design was a case-control study nested within a prospective investigation. Among the many comparisons, few polymorphisms were associated with the diseases at the univariate analysis: XRCC1-399 Gln/Gln variant homozygotes [odds ratios (OR) = 2.20, 95% confidence intervals (CI) = 1.16-4.17] and XRCC3-241 Met/Met homozygotes (OR = 0.51, 95% CI = 0.27-0.96) and leukaemia. The recessive model in the stepwise multivariate analysis revealed a possible protective effect of XRCC1-399Gln/Gln in lung cancer (OR = 0.22, 95% CI = 0.05-0.98), and confirmed an opposite effect (OR = 2.47, 95% CI = 1.02-6.02) in the leukaemia group. Our results also suggest that the XPD/ERCC1-GAT haplotype may modulate leukaemia (OR = 1.28, 95% CI = 1.02-1.61), bladder cancer (OR = 1.38, 95% CI = 1.06-1.79) and possibly other cancer risks. Further investigations of the combined effects of polymorphisms within these DNA repair genes, smoking and other risk factors may help to clarify the influence of genetic variation in the carcinogenic process. © 2006 Oxford University Press.
- Published
- 2006
29. Air pollution and risk of lung cancer in a prospective study in Europe
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Vineis, P. Hoek, G. Krzyzanowski, M. Vigna-Taglianti, F. Veglia, F. Airoldi, L. Autrup, H. Dunning, A. Garte, S. Hainaut, P. Malaveille, C. Matullo, G. Overvad, K. Raaschou-Nielsen, O. Clavel-Chapelon, F. Linseisen, J. Boeing, H. Trichopoulou, A. Palli, D. Peluso, M. Krogh, V. Tumino, R. Panico, S. Bas Bueno-De-Mesquita, H. Peeters, P.H. Lund, E.E. Gonzalez, C.A. Martinez, C. Dorronsoro, M. Barricarte, A. Cirera, L. Quiros, J.R. Berglund, G. Forsberg, B. Day, N.E. Key, T.J. Saracci, R. Kaaks, R. Riboli, E.
- Abstract
To estimate the relationship between air pollution and lung cancer, a nested case-control study was set up within EPIC (European Prospective Investigation on Cancer and Nutrition). Cases had newly diagnosed lung cancer, accrued after a median follow-up of 7 years among the EPIC exsmokers (since at least 10 years) and never smokers. Three controls per case were matched. Matching criteria were gender, age (±5 years), smoking status, country of recruitment and time elapsed between recruitment and diagnosis. We studied residence in proximity of heavy traffic roads as an indicator of exposure to air pollution. In addition, exposure to air pollutants (NO2, PM10, SO2) was assessed using concentration data from monitoring stations in routine air quality monitoring networks. Cotinine was measured in plasma. We found a nonsignificant association between lung cancer and residence nearby heavy traffic roads (odds ratio = 1.46, 95% confidence interval, CI, 0.89-2.40). Exposure data for single pollutants were available for 197 cases and 556 matched controls. For NO2 we found an odds ratio of 1.14 (95% CI, 0.78-1.67) for each increment of 10 μg/m3, and an odds ratio of 1.30 (1.02-1.66) for concentrations greater than 30 μg/m3. The association with NO2 did not change after adjustment by cotinine and additional potential confounders, including occupational exposures. No clear association was found with other pollutants. © 2006 Wiley-Liss, Inc.
- Published
- 2006
30. TP53 and KRAS2 mutations in plasma DNA of healthy subjects and subsequent cancer occurrence: a prospective study
- Author
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Gormally, E., Vineis, P., Matullo, G., Veglia, F., Caboux, E., Le Roux, E., Peluso, M., Garte, S., Guarrera, S., Munnia, A., Airoldi, L., and Autrup, Herman
- Published
- 2006
31. DNA adducts and lung cancer risk: A prospective study
- Author
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Peluso, M. Munnia, A. Hoek, G. Krzyzanowski, M. Veglia, F. Airoldi, L. Autrup, H. Dunning, A. Garte, S. Hainaut, P. Malaveille, C. Gormally, E. Matullo, G. Overvad, K. Raaschou-Nielsen, O. Clavel-Chapelon, F. Linseisen, J. Boeing, H. Trichopoulou, A. Trichopoulos, D. Kaladidi, A. Palli, D. Krogh, V. Tumino, R. Panico, S. Bueno-De-Mesquita, H.B. Peeters, P.H. Kumle, M. Gonzalez, C.A. Martinez, C. Dorronsoro, M. Barricarte, A. Navarro, C. Quiros, J.R. Berglund, G. Janzon, L. Jarvholm, B. Day, N.E. Key, T.J. Saracci, R. Kaaks, R. Riboli, E. Vineis, P.
- Abstract
Objectives were to investigate prospectively the ability of DNA adducts to predict cancer and to study the determinants of adducts, especially air pollutants. DNA adducts were measured in a case-control study nested in the European Prospective Investigation into Cancer and Nutrition (EPIC) investigation. Cases included newly diagnosed lung cancer (n = 115), upper respiratory cancers (pharynx and larynx; n = 82), bladder cancer (n = 124), leukemia (n = 166), and chronic obstructive pulmonary disease or emphysema deaths (n = 77) accrued after a median follow-up of 7 years among the EPIC former smokers and never-smokers. Three controls per case were matched for questionnaire analyses and two controls per case for laboratory analyses. Matching criteria were gender, age, smoking status, country of recruitment, and follow-up time. Individual exposure to air pollution was assessed using concentration data from monitoring stations in routine air quality monitoring networks. Leukocyte DNA adducts were analyzed blindly using 32P postlabeling technique. Adducts were associated with the subsequent risk of lung cancer, with an odds ratio (OR) of 1.86 [95% confidence interval (95% CI), 0.88-3.93] when comparing detectable versus nondetectable adducts. The association with lung cancer was stronger in never-smokers (OR, 4.04; 95% CI, 1.06-15.42) and among the younger age groups. After exclusion of the cancers occurring in the first 36 months of follow-up, the OR was 4.16 (95% CI, 1.24-13.88). A positive association was found between DNA adducts and ozone (O 3) concentration. Our prospective study suggests that leukocyte DNA adducts may predict lung cancer risk of never-smokers. Besides, the association of DNA adduct levels with O 3 indicates a possible role for photochemical smog in determining DNA damage. ©2005 American Association for Cancer Research.
- Published
- 2005
32. 4-Aminobiphenyl-hemoglobin adducts and risk of smoking-related disease in never smokers and former smokers in the European Prospective Investigation into Cancer and Nutrition prospective study
- Author
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Airoldi, L., Vineis, P., Colombi, A., Olgiati, L., Osta, C., Fanelli, R., Manzi, L., Veglia, F., Herman Autrup, Dunning, A., Garte, S., Hainaut, P., Hoeg, G., Kryzanowski, M., Malaveille, C., Matullo, G., Kim Overvad, Tjønneland, A., Clavel-Chapelon, F., Linseisen, J., Boeing, H., Trichopoulou, A., Palli, D., Peluso, M., Krogh, V., Tumino, R., Panico, S., Hb, Bueno-De-Mesquita, Ph, Peeters, Lund, E., Agudo, A., Martinez, C., Dorronsoro, M., Barricarte, A., Md, Chirlaque, Jr, Quiros, Berglund, G., Jarvholm, B., Hallmans, G., Ne, Day, Saracci, N., Kaaks, R., and Riboli, E.
- Published
- 2005
33. Polimorfismi dell'alcol deidrogenasi 3, glutatione S-transferasi M1 e T1, consumo di alcol e rischio di epatocarcinoma
- Author
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Franceschini, M., Covolo, Loredana, Gelatti, Umberto, Talamini, R., Garte, S., Franceschi, S., Barbone, F., Tagger, A., Ribero, M. L., and Parrinello, G.
- Published
- 2004
34. Amount of DNA in plasma and cancer risk: A prospective study
- Author
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Gormally, E Hainaut, P Caboux, E Airoldi, L Autrup, H and Malaveille, C Dunning, A Garte, S Matullo, G and Overvad, K Tjonneland, A Clavel-Chapelon, F Boffetta, P and Boeing, H Trichopoulou, A Palli, D Krogh, V Tumino, R and Panico, S Bueno-De-Mesquita, HB Peeters, PH Lund, E and Gonzalez, CA Martinez, C Dorronsoro, M Barricarte, A and Tormo, MJ Quiros, JR Berglund, G Hallmans, G Day, NE and Key, TJ Veglia, F Peluso, M Norat, T Saracci, R and Kaaks, R Riboli, E Vineis, P
- Abstract
Levels of plasma DNA concentrations in cancer patients have been shown to be higher than the plasma DNA concentrations found in healthy subjects. The value of plasma DNA levels for development of neoplastic or pulmonary disease was evaluated in a large prospective study. Plasma samples (n = 1, 184) were analyzed from 776 controls, 359 cases of cancer (lung, bladder, oral cavity, pharynx, larynx, leukemia) and 49 deaths from chronic obstructive pulmonary disease (COPD), including never smokers and ex-smokers, from 9 countries across Europe. The amount of plasma DNA was variable across the European Prospective Investigation into Cancer and Nutrition (EPIC) centers. High DNA concentrations in some centers might be due to the type of population recruited and/or the treatment of the samples. An elevated and statistically significant odds ratio (OR) was found for COPID deaths (OR = 2.53; 95% CI = 1.06-6.02), while nonsignificant increased ORs were present for oral cancers, cancers of the pharynx and larynx and leukemia. When the analyses were stratified by time since recruitment (below or above 36 months), the increased ORs were limited to the more recent period of recruitment, i.e., a time elapsed between blood drawing and disease onset lower than 36 months. This was particularly true for COPID deaths (OR = 12.7; 95% CI = 1.57-103) and leukemia (OR = 2.37; 95% Cl = 1.20-4.67). (C) 2004 Wiley-Liss, Inc.
- Published
- 2004
35. Genetic polymorphisms of Glutathione S-transferase and N-Acetyltransferase, cigarette smoking and hepatocellular carcinoma: a case-control study
- Author
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Gelatti, Umberto, Covolo, Loredana, Donato, Francesco, Barbone, F, Ribero, Ml, Franceschi, S, and Garte, S.
- Published
- 2003
36. Metabolic gene polymorphism frequencies in control populations
- Author
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Garte, S., Gaspari, L., Alexandrie, A. K., Ambrosone, C., Autrup, H., Autrup, J. L., Baranova, H., Bathum, L., Benhamou, S., Boffetta, P., Bouchardy, C., Breskvar, K., Brockmoller, J., Cascorbi, I., Clapper, M. L., Coutelle, C., Daly, A., Omo, M., Dolzan, V., Dresler, C. M., Fryer, A., Haugen, A., Hein, D. W., Hildesheim, A., Hirvonen, A., Hsieh, L. L., Ingelman-Sundberg, M., Kalina, I., Kang, D., Kihara, M., Kiyohara, C., Kremers, P., Lazarus, P., Le Marchand, L., Lechner, M. C., Lieshout, E. M., Stephanie London, Manni, J. J., Maugard, C. M., Morita, S., Nazar-Stewart, V., Noda, K., Oda, Y., Parl, F. F., Pastorelli, R., Persson, I., Peters, W. H., Rannug, A., Rebbeck, T., Risch, A., Roelandt, L., Romkes, M., Ryberg, D., Salagovic, J., Schoket, B., Seidegard, J., Shields, P. G., Sim, E., Sinnet, D., Strange, R. C., Stucker, I., Sugimura, H., To-Figueras, J., Vineis, P., Yu, M. C., and Taioli, E.
- Subjects
Polymorphism, Genetic ,Metabole aspecten van maag-, darm- en leveraandoeningen ,Cytochrome P-450 Enzyme System ,Databases, Factual ,Gene Frequency ,Genetic Linkage ,Neoplasms ,Black People ,Humans ,Metabolic aspects of gastrointestinal diseases ,Genetic Predisposition to Disease ,White People - Abstract
Item does not contain fulltext Using the International Project on Genetic Susceptibility to Environmental Carcinogens (GSEC) database containing information on over 15,000 control (noncancer) subjects, the allele and genotype frequencies for many of the more commonly studied metabolic genes (CYP1A1, CYP2E1, CYP2D6, GSTM1, GSTT1, NAT2, GSTP, and EPHX) in the human population were determined. Major and significant differences in these frequencies were observed between Caucasians (n = 12,525), Asians (n = 2,136), and Africans and African Americans (n = 996), and some, but much less, heterogeneity was observed within Caucasian populations from different countries. No differences in allele frequencies were seen by age, sex, or type of controls (hospital patients versus population controls). No examples of linkage disequilibrium between the different loci were detected based on comparison of observed and expected frequencies for combinations of specific alleles.
- Published
- 2001
37. Metabolic gene polymorphism frequencies in control populations
- Author
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Garte, S, Gaspari, L, Alexandrie, Ak, Ambrosone, C, Autrup, H, Autrup, Jl, Baranova, H, Bathum, L, Benhamou, S, Boffetta, P, Bouchardy, C, Breskvar, K, Brockmoller, J, Cascorbi, I, Clapper, Ml, Coutelle, C, Daly, A, Dell'Omo, Marco, Dolzan, V, Dresler, Cm, Fryer, A, Haugen, A, Hein, Dw, Hildesheim, A, Hirvonen, A, Hsieh, Ll, Ingelman, Sundberg, M, Kalina, I, Kang, D, Kihara, M, Kiyohara, C, Kremers, P, Lazarus, P, LE MARCHAND, L, Lechner, Mc, VAN LIESHOUT EM, London, S, Manni, Jj, Maugard, Cm, Morita, S, NAZAR STEWART, V, Noda, K, Oda, Y, Parl, Ff, Pastorelli, R, Persson, I, Peters, Wh, Rannug, A, Rebbeck, T, Risch, A, Roelandt, L, Romkes, M, Ryberg, D, Salagovic, J, Schoket, B, Seidegard, J, Shields, Pg, Sim, E, Sinnet, D, Strange, Rc, Stücker, I, Sugimura, H, TO FIGUERAS, J, Vineis, P, Yu, Mc, and Taioli, E.
- Published
- 2001
38. Association between Polycyclic Aromatic Hydrocarbon-DNA adduct levels in maternal and newborn white blood cells and glutathione S-transferase P1 and CYP 1A1 polymorphisms
- Author
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Whyatt, Rm, Perera, Fp, Jedrychowski, W., Santella, Rm, Garte, S., and Douglas Bell
- Published
- 2000
39. Comparison of estrogens and estrogen metabolites in human breast tissue and urine
- Author
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Taioli, E, Im, A, Xu, X, Veenstra, TD, Ahrendt, G, Garte, S, Taioli, E, Im, A, Xu, X, Veenstra, TD, Ahrendt, G, and Garte, S
- Abstract
Background: An important aspect of the link between estrogen and breast cancer is whether urinary estrogen levels are representative of the intra-tissue levels of bioavailable estrogens.Methods: This study compares 15 estrogen and estrogen metabolite levels in breast tissue and urine of 9 women with primary breast cancer using a quantitative liquid chromatography-mass spectrometry method.Results: The average levels of estrogens (estrone, 17 beta-estradiol) were significantly higher in breast tissue than in urine. Both the 2 and the 16-hydroxylation pathways were less represented in breast tissue than urine; no components of the 4-hydroxypathway were detected in breast tissue, while 4-hydroxyestrone was measured in urine. However, the 2/16 ratio was similar in urine and breast tissue. Women carrying the variant CYP1B1 genotype (Leu/Val and Val/Val) showed significantly lower overall estrogen metabolite, estrogen, and 16-hydroxylation pathway levels in breast tissue in comparison to women carrying the wild type genotype. No effect of the CYP1B1 polymorphism was observed in urinary metabolites.Conclusions: The urinary 2/16 ratio seems a good approximation of the ratio observed in breast tissue. Metabolic genes may have an important role in the estrogen metabolism locally in tissues where the gene is expressed, a role that is not readily observable when urinary measurements are performed. © 2010 Taioli et al; licensee BioMed Central Ltd.
- Published
- 2010
40. Quantitative analysis of DNA methylation after whole bisulfitome amplification of a minute amount of DNA from body fluids.
- Author
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Vaissière, Thomas, Cuenin, Cyrille, Paliwal, Anupam, Vineis, Paolo, Hoek, G, Krzyzanowski, M, Airoldi, L, Dunning, A, Garte, S, Hainaut, P, Malaveille, C, Overvad, K, Clavel-Chapelon, F, Linseisen, J, Boeing, H, Trichopoulou, A, Trichopoulos, D, Kaladidi, A, Palli, D, Krogh, V, Tumino, R, Panico, S, Bueno-De-Mesquita, H B, Peeters, P H, Kumle, M, Gonzalez, C A, Martinez, C, Dorronsoro, M, Barricarte, A, Navarro, C, Quiros, J R, Berglund, G, Janzon, L, Jarvholm, B, Day, N E, Key, T J, Saracci, R, Kaaks, R, Riboli, E, Hainaut, Pierre, Herceg, Zdenko, Vaissière, Thomas, Cuenin, Cyrille, Paliwal, Anupam, Vineis, Paolo, Hoek, G, Krzyzanowski, M, Airoldi, L, Dunning, A, Garte, S, Hainaut, P, Malaveille, C, Overvad, K, Clavel-Chapelon, F, Linseisen, J, Boeing, H, Trichopoulou, A, Trichopoulos, D, Kaladidi, A, Palli, D, Krogh, V, Tumino, R, Panico, S, Bueno-De-Mesquita, H B, Peeters, P H, Kumle, M, Gonzalez, C A, Martinez, C, Dorronsoro, M, Barricarte, A, Navarro, C, Quiros, J R, Berglund, G, Janzon, L, Jarvholm, B, Day, N E, Key, T J, Saracci, R, Kaaks, R, Riboli, E, Hainaut, Pierre, and Herceg, Zdenko
- Abstract
Cell-free circulating DNA isolated from the plasma of individuals with cancer has been shown to harbor cancer-associated changes in DNA methylation, and thus it represents an attractive target for biomarker discovery. However, the reliable detection of DNA methylation changes in body fluids has proven to be technically challenging. Here we describe a novel combination of methods that allows quantitative and sensitive detection of DNA methylation in minute amounts of DNA present in body fluids (quantitative Methylation Analysis of Minute DNA amounts after whole Bisulfitome Amplification, qMAMBA). This method involves genome-wide amplification of bisulphite-modified DNA template followed by quantitative methylation detection using pyrosequencing and allows analysis of multiple genes from a small amount of starting DNA. To validate our method we used qMAMBA assays for four genes and LINE1 repetitive sequences combined with plasma DNA samples as a model system. qMAMBA offered high efficacy in the analysis of methylation levels and patterns in plasma samples with extremely small amounts of DNA and low concentrations of methylated alleles. Therefore, qMAMBA will facilitate methylation studies aiming to discover epigenetic biomarkers, and should prove particularly valuable in profiling a large sample series of body fluids from molecular epidemiology studies as well as in tracking disease in early diagnostics.
- Published
- 2009
41. Quantitative analysis of DNA methylation after whole bisulfitome amplification of a minute amount of DNA from body fluids.
- Author
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Risk Assessment of Toxic and Immunomodulatory Agents, Dep IRAS, Vaissiere, T., Cuenin, C., Paliwal, A., Vineis, P., Hoek, G., Krzyzanowski, M., Airoldi, L., Dunning, A., Garte, S., Malaveille, C., Overvad, K., Clavel-Chapelon, F., Linseisen, J., Boeing, H., Trichopoulou, A., Trichopoulous, D., Kaladidi, A., Palli, D., Krogh, V., Tumino, R., Panico, S., Bueno de Mesquita, H.B., Peeters, P.H.M., Kumle, M., Gonzalez, C.A., Martinez, C., Dorronsoro, M., Barricarte, A., Navarro, C., Quiros, J.R., Berglund, B., Janzon, L., Jarvholm, B., Day, N.E., Key, T.J., Saracci, R., Kaaks, R., Riboli, E., Hainaut, P., Herceg, Z., Risk Assessment of Toxic and Immunomodulatory Agents, Dep IRAS, Vaissiere, T., Cuenin, C., Paliwal, A., Vineis, P., Hoek, G., Krzyzanowski, M., Airoldi, L., Dunning, A., Garte, S., Malaveille, C., Overvad, K., Clavel-Chapelon, F., Linseisen, J., Boeing, H., Trichopoulou, A., Trichopoulous, D., Kaladidi, A., Palli, D., Krogh, V., Tumino, R., Panico, S., Bueno de Mesquita, H.B., Peeters, P.H.M., Kumle, M., Gonzalez, C.A., Martinez, C., Dorronsoro, M., Barricarte, A., Navarro, C., Quiros, J.R., Berglund, B., Janzon, L., Jarvholm, B., Day, N.E., Key, T.J., Saracci, R., Kaaks, R., Riboli, E., Hainaut, P., and Herceg, Z.
- Published
- 2009
42. Meat intake and bladder cancer in a prospective study : a role for heterocyclic aromatic amines?
- Author
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Lumbreras, B, Garte, S, Overvad, K, Tjonneland, A, Clavel-Chapelon, F, Linseisen, J P, Boeing, H, Trichopoulou, A, Palli, D, Peluso, M, Krogh, V, Tumino, R, Panico, S, Bueno-De-Mesquita, H B, Peeters, P H, Lund, E, Martinez, C, Dorronsoro, M, Barricarte, A, Chirlaque, M-D, Quiros, J R, Berglund, G, Hallmans, Göran, Day, N E, Key, T J, Saracci, R, Kaaks, R, Malaveille, C, Ferrari, P, Boffetta, P, Norat, T, Riboli, E, Gonzalez, C A, Vineis, P, Lumbreras, B, Garte, S, Overvad, K, Tjonneland, A, Clavel-Chapelon, F, Linseisen, J P, Boeing, H, Trichopoulou, A, Palli, D, Peluso, M, Krogh, V, Tumino, R, Panico, S, Bueno-De-Mesquita, H B, Peeters, P H, Lund, E, Martinez, C, Dorronsoro, M, Barricarte, A, Chirlaque, M-D, Quiros, J R, Berglund, G, Hallmans, Göran, Day, N E, Key, T J, Saracci, R, Kaaks, R, Malaveille, C, Ferrari, P, Boffetta, P, Norat, T, Riboli, E, Gonzalez, C A, and Vineis, P
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- 2008
43. Complex exposures - air pollution
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Wild, C., Vineis, P., Garte, S., Loft, Steffen, Bräuner, Elvira Vaclavik, Forchhammer, Lykke Ali, Pedersen, Marie, Knudsen, Lisbeth E., Møller, Peter, Wild, C., Vineis, P., Garte, S., Loft, Steffen, Bräuner, Elvira Vaclavik, Forchhammer, Lykke Ali, Pedersen, Marie, Knudsen, Lisbeth E., and Møller, Peter
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- 2008
44. Urinary excretion of 1-hydroxypyrene as a marker for exposure to urban air levels of polycyclic aromatic hydrocarbons
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Merlo F, Andreassen A, Weston A, Cf, Pan, Haugen A, Valerio F, Giorgio Reggiardo, Fontana V, Garte S, Puntoni R, and Abbondandolo A
- Subjects
Male ,Air Pollutants ,Polymorphism, Genetic ,Pyrenes ,Urban Population ,Smoking ,Environmental Exposure ,Middle Aged ,Police ,Age Distribution ,Cross-Sectional Studies ,Italy ,Air Pollution, Indoor ,Creatinine ,Humans ,Female ,Tobacco Smoke Pollution ,Polycyclic Aromatic Hydrocarbons ,Sex Distribution ,Biomarkers - Abstract
A cross-sectional study was conducted among 94 traffic police officers from the Municipality Police of Genoa, Italy, exposed to airborne pollutants and 52 referent subjects exposed to indoor air pollution levels to investigate the relationships between exposure to ambient air polycyclic aromatic hydrocarbons (PAHs) and urinary excretion of 1-hydroxypyrene (1-OH-P). The effects of smoking, lifestyle factors such as exposure to ETS, and diet, along with the role played by the cytochrome P4501A1 (CYP1A1), and glutathione S-transferase M1 and theta metabolic susceptibility gene polymorphisms were examined. The geometric mean of benzo(a)pyrene air measurements (an index compound of PAH levels) was 70 times higher in traffic police officers (3.67 ng/m3) than in referents (0.05 ng/m3). The urinary concentration of 1-OH-P was clearly associated with cigarette smoking and, to a lesser extent, with exposure to ETS and particulate PAH pollution. No association was detected between 1-OH-P excretion and diet. Women exhibited a higher excretion level than did men, and an apparent effect of age was due to differences in cigarette smoking habits. Exposure to PAHs resulted in higher levels of 1-OH-P excretion in all groups except heavy smokers. Overall, no significant role of any metabolic polymorphism was detected. However, stratification of study subjects according to their smoking habits revealed higher levels of excretion of 1-OH-P in subjects smokingor =15 cigarettes/day carrying the CYP1A1 polymorphism. No such effect was seen either with nonsmokers or with people smoking more than 15 cigarettes/day. These findings are suggestive of a gene-environment interaction, in which subjects with the CYP1A1 polymorphism, relative to subjects without it, have higher levels of 1-OH-P in their urine at low doses of exposure to PAHs.
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- 1998
45. Multi-factor dimensionality reduction applied to a large prospective investigation on gene-gene and gene-environment interactions.
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Manuguerra, M, Matullo, G, Veglia, F, Autrup, H, Dunning, A M, Garte, S, Gormally, E, Malaveille, C, Guarrera, S, Polidoro, S, Saletta, F, Peluso, M, Airoldi, L, Overvad, K, Raaschou-Nielsen, O, Clavel-Chapelon, F, Linseisen, J, Boeing, H, Trichopoulos, D, Kalandidi, A, Palli, D, Krogh, V, Tumino, R, Panico, S, Bueno-De-Mesquita, H B, Peeters, P H, Lund, E, Pera, G, Martinez, C, Amiano, P, Barricarte, A, Tormo, M J, Quiros, J R, Berglund, G, Janzon, L, Jarvholm, B, Day, N E, Allen, N E, Saracci, R, Kaaks, R, Ferrari, P, Riboli, E, Vineis, P, Manuguerra, M, Matullo, G, Veglia, F, Autrup, H, Dunning, A M, Garte, S, Gormally, E, Malaveille, C, Guarrera, S, Polidoro, S, Saletta, F, Peluso, M, Airoldi, L, Overvad, K, Raaschou-Nielsen, O, Clavel-Chapelon, F, Linseisen, J, Boeing, H, Trichopoulos, D, Kalandidi, A, Palli, D, Krogh, V, Tumino, R, Panico, S, Bueno-De-Mesquita, H B, Peeters, P H, Lund, E, Pera, G, Martinez, C, Amiano, P, Barricarte, A, Tormo, M J, Quiros, J R, Berglund, G, Janzon, L, Jarvholm, B, Day, N E, Allen, N E, Saracci, R, Kaaks, R, Ferrari, P, Riboli, E, and Vineis, P
- Abstract
It is becoming increasingly evident that single-locus effects cannot explain complex multifactorial human diseases like cancer. We applied the multi-factor dimensionality reduction (MDR) method to a large cohort study on gene-environment and gene-gene interactions. The study (case-control nested in the EPIC cohort) was established to investigate molecular changes and genetic susceptibility in relation to air pollution and environmental tobacco smoke (ETS) in non-smokers. We have analyzed 757 controls and 409 cases with bladder cancer (n=124), lung cancer (n=116) and myeloid leukemia (n=169). Thirty-six gene variants (DNA repair and metabolic genes) and three environmental exposure variables (measures of air pollution and ETS at home and at work) were analyzed. Interactions were assessed by prediction error percentage and cross-validation consistency (CVC) frequency. For lung cancer, the best model was given by a significant gene-environment association between the base excision repair (BER) XRCC1-Arg399Gln polymorphism, the double-strand break repair (DSBR) BRCA2-Asn372His polymorphism and the exposure variable 'distance from heavy traffic road', an indirect and robust indicator of air pollution (mean prediction error of 26%, P<0.001, mean CVC of 6.60, P=0.02). For bladder cancer, we found a significant 4-loci association between the BER APE1-Asp148Glu polymorphism, the DSBR RAD52-3'-untranslated region (3'-UTR) polymorphism and the metabolic gene polymorphisms COMT-Val158Met and MTHFR-677C>T (mean prediction error of 22%, P<0.001, mean CVC consistency of 7.40, P<0.037). For leukemia, a 3-loci model including RAD52-2259C>T, MnSOD-Ala9Val and CYP1A1-Ile462Val had a minimum prediction error of 31% (P<0.001) and a maximum CVC of 4.40 (P=0.086). The MDR method seems promising, because it provides a limited number of statistically stable interactions; however, the biological interpretation remains to be understood.
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- 2007
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46. Genetic susceptibility according to three metabolic pathways in cancers of the lung and bladder and in myeloid leukemias in nonsmokers.
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Vineis, P, Veglia, F, Garte, S, Malaveille, C, Matullo, G, Dunning, A, Peluso, M, Airoldi, L, Overvad, K, Raaschou-Nielsen, O, Clavel-Chapelon, F, Linseisen, J P, Kaaks, R, Boeing, H, Trichopoulou, A, Palli, D, Crosignani, P, Tumino, R, Panico, S, Bueno-De-Mesquita, H B, Peeters, P H, Lund, E, Gonzalez, C A, Martinez, C, Dorronsoro, M, Barricarte, A, Navarro, C, Quiros, J R, Berglund, G, Jarvholm, B, Day, N E, Key, T J, Saracci, R, Riboli, E, Autrup, H, Vineis, P, Veglia, F, Garte, S, Malaveille, C, Matullo, G, Dunning, A, Peluso, M, Airoldi, L, Overvad, K, Raaschou-Nielsen, O, Clavel-Chapelon, F, Linseisen, J P, Kaaks, R, Boeing, H, Trichopoulou, A, Palli, D, Crosignani, P, Tumino, R, Panico, S, Bueno-De-Mesquita, H B, Peeters, P H, Lund, E, Gonzalez, C A, Martinez, C, Dorronsoro, M, Barricarte, A, Navarro, C, Quiros, J R, Berglund, G, Jarvholm, B, Day, N E, Key, T J, Saracci, R, Riboli, E, and Autrup, H
- Abstract
BACKGROUND: We chose a set of candidate single nucleotide polymorphisms (SNPs) to investigate gene-environment interactions in three types of cancer that have been related to air pollution (lung, bladder and myeloid leukemia). PATIENTS AND METHODS: The study has been conducted as a nested case-control study within the European Prospective Investigation into Cancer and Nutrition cohort (409 cancer cases and 757 matched controls). We included never and ex-smokers. SNPs were in genes involved in oxidative stress, phase I metabolizing genes, phase II metabolizing genes and methylenetetrahydrofolate reductase (MTHFR). RESULTS: The most notable findings are: GSTM1 deletion and bladder cancer risk [odds ratio (OR) = 1.60; 95% confidence interval 1.00-2.56]; CYP1A1 and leukemia (2.22, 1.33-3.70; heterozygotes); CYP1B1 and leukemia (0.47, 0.27-0.84; homozygotes); MnSOD and leukemia (1.91, 1.08-3.38; homozygotes) and NQO1 and lung cancer (8.03, 1.73-37.3; homozygotes). Other statistically significant associations were found in subgroups defined by smoking habits (never or ex-smokers), environmental tobacco smoke or gender, with no obvious pattern. When gene variants were organized according to the three main pathways, the emerging picture was of a strong involvement of combined phase I enzymes in leukemia, with an OR of 5 (1.63-15.4) for those having three or more variant alleles. The association was considerably stronger for leukemias arising before the age of 55.
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- 2007
- Full Text
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47. DNA adducts and lung cancer risk: a prospective study.
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Faculteit Diergeneeskunde, Peluso, M., Munnia, A., Hoek, G., Krzyzanowski, M., Veglia, F., Airoldi, L., Autrup, H., Dunning, A., Garte, S., Hainaut, P., Malaveille, C., Gormally, E., Matullo, G., Overvad, K., Raaschou-Nielsen, O., Clavel-Chapelon, F., Linseisen, J., Boeing, H.H., Trichopoulou, A., Trichopoulos, D., Kaladidi, A., Palli, D., Krogh, V., Tumino, R., Panico, S., Bueno de Mesquita, H.B., Peeters, P.H.M., Kumle, M., Gonzalez, C.A., Martinez, C., Dorronsoro, M., Barricarte, A., Navarro, C., Quiros, J.R., Berglund, G., Janzon, L., Jarvholm, B., Day, N.E., Key, T.J., Saracci, R., Kaaks, R., Riboli, E., Vineis, P., Faculteit Diergeneeskunde, Peluso, M., Munnia, A., Hoek, G., Krzyzanowski, M., Veglia, F., Airoldi, L., Autrup, H., Dunning, A., Garte, S., Hainaut, P., Malaveille, C., Gormally, E., Matullo, G., Overvad, K., Raaschou-Nielsen, O., Clavel-Chapelon, F., Linseisen, J., Boeing, H.H., Trichopoulou, A., Trichopoulos, D., Kaladidi, A., Palli, D., Krogh, V., Tumino, R., Panico, S., Bueno de Mesquita, H.B., Peeters, P.H.M., Kumle, M., Gonzalez, C.A., Martinez, C., Dorronsoro, M., Barricarte, A., Navarro, C., Quiros, J.R., Berglund, G., Janzon, L., Jarvholm, B., Day, N.E., Key, T.J., Saracci, R., Kaaks, R., Riboli, E., and Vineis, P.
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- 2005
48. 4-Aminobiphenyl-hemoglobin adducts and risk of smoking-related disease in never smokers and former smokers in the european prospective investigation into cancer and nutrition prospective study
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Faculteit Diergeneeskunde, Airoldi, L., Vineis, P., Colombi, A., Olgiati, L., Dell'Osta, C., Fanelli, R., Manzi, L., Veglia, F., Autrup, H., Dunning, A., Garte, S., Hainaut, P., Hoek, G., Krzyzanowski, M., Malaveille, C., Matullo, G., Overvad, K., Tjonneland, A., Clavel Chapelon, F., Linseisen, J., Boeing, H.H., Trichopoulou, A., Palli, D., Peluso, M., Krogh, V., Tumino, R., Panico, S., Bueno de Mesquita, H.B., Peeters, P.H.M., Lund, E., Agudo, A., Martinez, C., Dorronsoro, M., Barricarte, A., Chirlaque, M.D., Quiros, J.R., Berglund, G., Jarvholm, B., Hallmans, G., Day, N.E., Allen, N., Saracci, R., Kaaks, R., Riboli, E., Faculteit Diergeneeskunde, Airoldi, L., Vineis, P., Colombi, A., Olgiati, L., Dell'Osta, C., Fanelli, R., Manzi, L., Veglia, F., Autrup, H., Dunning, A., Garte, S., Hainaut, P., Hoek, G., Krzyzanowski, M., Malaveille, C., Matullo, G., Overvad, K., Tjonneland, A., Clavel Chapelon, F., Linseisen, J., Boeing, H.H., Trichopoulou, A., Palli, D., Peluso, M., Krogh, V., Tumino, R., Panico, S., Bueno de Mesquita, H.B., Peeters, P.H.M., Lund, E., Agudo, A., Martinez, C., Dorronsoro, M., Barricarte, A., Chirlaque, M.D., Quiros, J.R., Berglund, G., Jarvholm, B., Hallmans, G., Day, N.E., Allen, N., Saracci, R., Kaaks, R., and Riboli, E.
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- 2005
49. Association of metabolic gene polymorphisms with alcohol consumption in controls.
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Raimondi, S.C., Benhamou, S., Coutelle, C., Garte, S., Hayes, R., Kiemeney, L.A.L.M., Lazarus, P., Marchand, L.L., Morita, S., Povey, A., Romkes, M., Zijno, A., Taioli, E., Raimondi, S.C., Benhamou, S., Coutelle, C., Garte, S., Hayes, R., Kiemeney, L.A.L.M., Lazarus, P., Marchand, L.L., Morita, S., Povey, A., Romkes, M., Zijno, A., and Taioli, E.
- Abstract
Contains fulltext : 58544.pdf (publisher's version ) (Closed access), The objectives were to study the association between metabolic genes involved in alcohol metabolism (CYP2E1 RsaI, CYP2E1 DraI, ADH1C, NQO1) and alcohol consumption in a large sample of healthy controls. Healthy subjects were selected from the International Collaborative Study on Genetic Susceptibility to Environmental Carcinogens (GSEC). Subjects with information on both alcohol consumption and at least one of the studied polymorphisms were included in the analysis (n=2224). Information on the amount of alcohol consumption was available for a subset of subjects (n=844). None of the studied genes was significantly associated with drinking habits. A significant heterogeneity with age was observed when studying the association between CYP2E1 RsaI and alcohol drinking. CYP2E1 RsaI polymorphism was significantly associated with being a never drinker at older ages (odds ratio [OR] 2.4, 95% confidence interval [CI] 1.2-4.8; at ages above 68 years), while the association was reversed at ages below 47 years (OR 0.5, 95% CI 0.2-1.4). For subjects with detailed information on alcohol intake, no association between alcohol quantity and polymorphisms in metabolic genes was observed; subjects carrying the NQO1 polymorphism tended to drink more than subjects carrying the wild-type alleles. Therefore, no significant association between CYP2E1 RsaI, CYP2E1 DraI, ADH1C, NQO1 polymorphisms and alcohol consumption was observed in healthy controls.
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- 2004
50. Association of metabolic gene polymorphisms with tobacco consumption in healthy controls.
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Smits, K.M., Benhamou, S., Garte, S., Weijenberg, M.P., Alamanos, Y., Ambrosone, C., Autrup, H., Autrup, J.L., Baranova, H., Bathum, L., Boffetta, P., Bouchardy, C., Brockmoller, J., Butkiewicz, D., Cascorbi, I., Clapper, M.L., Coutelle, C., Daly, A., Muzi, G., Dolzan, V., Duzhak, T.G., Farker, K., Golka, K., Haugen, A., Hein, D.W., Hildesheim, A., Hirvonen, A., Hsieh, L.L., Ingelman-Sundberg, M., Kalina, I., Kang, D., Katoh, T., Kihara, M., Ono-Kihara, M., Kim, H.L., Kiyohara, C., Kremers, P., Lazarus, P., Marchand, L. le, Lechner, M.C., London, S., Manni, J.J., Maugard, C.M., Morgan, G.J., Morita, S., Nazar-Stewart, V., Kristensen, V.N., Oda, Y., Parl, F.F., Peters, W.H.M., Rannug, A., Rebbeck, T.R., Pinto, L.F., Risch, A., Romkes, M., Salagovic, J., Schoket, B., Seidegard, J., Shields, P.G., Sim, E., Sinnett, D., Strange, R.C., Stucker, I., Sugimura, H., To-Figueras, J., Vineis, P., Yu, M.C., Zheng, W., Pedotti, P., Taioli, E., Smits, K.M., Benhamou, S., Garte, S., Weijenberg, M.P., Alamanos, Y., Ambrosone, C., Autrup, H., Autrup, J.L., Baranova, H., Bathum, L., Boffetta, P., Bouchardy, C., Brockmoller, J., Butkiewicz, D., Cascorbi, I., Clapper, M.L., Coutelle, C., Daly, A., Muzi, G., Dolzan, V., Duzhak, T.G., Farker, K., Golka, K., Haugen, A., Hein, D.W., Hildesheim, A., Hirvonen, A., Hsieh, L.L., Ingelman-Sundberg, M., Kalina, I., Kang, D., Katoh, T., Kihara, M., Ono-Kihara, M., Kim, H.L., Kiyohara, C., Kremers, P., Lazarus, P., Marchand, L. le, Lechner, M.C., London, S., Manni, J.J., Maugard, C.M., Morgan, G.J., Morita, S., Nazar-Stewart, V., Kristensen, V.N., Oda, Y., Parl, F.F., Peters, W.H.M., Rannug, A., Rebbeck, T.R., Pinto, L.F., Risch, A., Romkes, M., Salagovic, J., Schoket, B., Seidegard, J., Shields, P.G., Sim, E., Sinnett, D., Strange, R.C., Stucker, I., Sugimura, H., To-Figueras, J., Vineis, P., Yu, M.C., Zheng, W., Pedotti, P., and Taioli, E.
- Abstract
Contains fulltext : 58545.pdf (publisher's version ) (Closed access), Polymorphisms in genes that encode for metabolic enzymes have been associated with variations in enzyme activity between individuals. Such variations could be associated with differences in individual exposure to carcinogens that are metabolized by these genes. In this study, we examine the association between polymorphisms in several metabolic genes and the consumption of tobacco in a large sample of healthy individuals. The database of the International Collaborative Study on Genetic Susceptibility to Environmental Carcinogens was used. All the individuals who were controls from the case-control studies included in the data set with information on smoking habits and on genetic polymorphisms were selected (n = 20938). Sufficient information was available on the following genes that are involved in the metabolism of tobacco smoke constituents: CYP1A1, GSTM1, GSTT1, NAT2 and GSTP1. None of the tested genes was clearly associated with smoking behavior. Information on smoking dose, available for a subset of subjects, showed no effect of metabolic gene polymorphisms on the amount of smoking. No association between polymorphisms in the genes studied and tobacco consumption was observed; therefore, no effect of these genes on smoking behavior should be expected.
- Published
- 2004
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