1. New Surgery and Hospital-diagnosed Infections in Elderly Patients with Inflammatory Bowel Disease Undergoing Surgery: A Nationwide Cohort Study.
- Author
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Nørgård BM, Garvik OS, Zegers FD, Nielsen J, Lund K, Knudsen T, and Kjeldsen J
- Subjects
- Humans, Male, Female, Denmark epidemiology, Middle Aged, Aged, Adult, Cohort Studies, Adolescent, Registries, Young Adult, Inflammatory Bowel Diseases surgery, Inflammatory Bowel Diseases complications, Digestive System Surgical Procedures adverse effects, Digestive System Surgical Procedures statistics & numerical data, Digestive System Surgical Procedures methods, Risk Factors, Proportional Hazards Models, Age Factors, Crohn Disease surgery, Crohn Disease epidemiology, Crohn Disease complications, Postoperative Complications epidemiology, Postoperative Complications etiology, Postoperative Complications diagnosis, Colitis, Ulcerative surgery, Colitis, Ulcerative complications
- Abstract
Background: Elderly patients with inflammatory bowel disease [IBD] are fragile in many respects. Therefore, in these patients, we studied postoperative complications [new abdominal surgery and serious infections after the first IBD surgery]., Methods: This is a nationwide cohort study based on Danish health registries and included patients with IBD undergoing surgery. The study population was split into ulcerative colitis [UC] and Crohn's disease [CD]. The exposed cohort [elderly] constituted those at an age of ≥60 years at first IBD surgery, and the unexposed [adults] those with surgery at the age of 18-59 years. We estimated adjusted hazard ratios [aHRs] of: a] new abdominal surgery within 2 years; and b] serious [hospital-diagnosed] infections within 6 and 12 months. We adjusted for several confounders including type of index surgery [laparoscopic or open]., Results: The aHR for a new surgery among elderly with UC and CD were 0.69 [95% CI 0.58-0.83] and 0.98 [95% CI 0.83-1.15], respectively. In elderly with UC, the aHRs of infections within 6 and 12 months after surgery were 1.07 [95% CI 0.81-1.40] and 0.85 [95% CI 0.67-1.08], respectively. In the elderly with CD, the aHRs of infections within 6 and 12 months were 1.45 [95% CI 1.12-1.88] and 1.26 [95% CI 1.00-1.59], respectively., Conclusion: The elderly with IBD did not have an increased risk of new abdominal surgery within 2 years of the first surgery. Elderly with CD, but not UC, had an increased risk of serious infections within 6 months of surgery., (© The Author(s) 2024. Published by Oxford University Press on behalf of European Crohn’s and Colitis Organisation. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.)
- Published
- 2024
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