622 results on '"Garzi, A"'
Search Results
2. Common and Uncommon CT Findings in CVID-Related GL-ILD: Correlations with Clinical Parameters, Therapeutic Decisions and Potential Implications in the Differential Diagnosis
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Scarpa, Riccardo, Cinetto, Francesco, Milito, Cinzia, Gianese, Sabrina, Soccodato, Valentina, Buso, Helena, Garzi, Giulia, Carrabba, Maria, Messina, Emanuele, Panebianco, Valeria, Catalano, Carlo, Morana, Giovanni, Lougaris, Vassilios, Landini, Nicholas, and Bondioni, Maria Pia
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- 2023
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3. High Prevalence of Long COVID in Common Variable Immunodeficiency: An Italian Multicentric Study
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Villa, Annalisa, Milito, Cinzia, Deiana, Carla Maria, Finco Gambier, Renato, Punziano, Alessandra, Buso, Helena, Bez, Patrick, Lagnese, Gianluca, Garzi, Giulia, Costanzo, Giulia, Giannuzzi, Gloria, Pagnozzi, Chiara, Dalm, Virgil A. S. H., Spadaro, Giuseppe, Rattazzi, Marcello, Cinetto, Francesco, and Firinu, Davide
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- 2024
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4. SARS-CoV-2 vaccination in primary antibody deficiencies: an overview on efficacy, immunogenicity, durability of immune response and safety
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Cusa, Gabriella, Sardella, Germano, Garzi, Giulia, Firinu, Davide, and Milito, Cinzia
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- 2024
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- View/download PDF
5. Safety of mRNA COVID-19 Vaccines in Patients with Inborn Errors of Immunity: an Italian Multicentric Study
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Milito, Cinzia, Cinetto, Francesco, Garzi, Giulia, Palladino, Andrea, Puca, Marco, Brambilla, Elena, De Vitis, Camilla, Costanzo, Giulia, Scarpa, Riccardo, Punziano, Alessandra, Lagnese, Gianluca, Del Giacco, Stefano, Spadaro, Giuseppe, Quinti, Isabella, and Firinu, Davide
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- 2023
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6. SARS-CoV-2 pre-exposure prophylaxis with tixagevimab/cilgavimab (AZD7442) provides protection in inborn errors of immunity with antibody defects: a real-world experience
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Federica Pulvirenti, Giulia Garzi, Cinzia Milito, Eleonora Sculco, Maddalena Sciannamea, Anna Napoli, Lilia Cinti, Piergiorgio Roberto, Alessandra Punziano, Maria Carrabba, Eva Piano Mortari, Rita Carsetti, Guido Antonelli, and Isabella Quinti
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SARS-CoV-2 ,COVID-19 ,inborn errors of immunity ,immunoglobulin replacement (IgRT) ,monoclonal antibody ,tixagevimab/cilgavimab prophylaxis ,Immunologic diseases. Allergy ,RC581-607 - Abstract
BackgroundPreventive strategies against severe COVID-19 in Inborn Errors of Immunity (IEI) include bivalent vaccines, treatment with SARS-CoV-2 monoclonal antibodies (mAbs), early antiviral therapies, and pre-exposure prophylaxis (PrEP).ObjectiveTo assess the effectiveness of the PrEP with tixagevimab/cilgavimab (AZD7442) in IEI with primary antibody defects during the COVID-19 Omicron wave.MethodsA six-month prospective study evaluated the SARS-CoV-2 infection rate and the COVID-19 severity in the AZD7442 group, in the no-AZD7442 group, and in a group of patients with a recent SARS-CoV-2 infection (< three months). Spike-specific IgG levels were measured at regular intervals.ResultsSix out of thirty-three patients (18%) and 54/170 patients (32%) became infected in the AZD7442 group and in the no-AZD7442 group, respectively. Within 90 days post-administration, the AZD7442 group was 85% less likely to be infected and 82% less likely to have a symptomatic disease than the no-AZD7442 group. This effect was lost thereafter. In the entire cohort, no mortality/hospitalisation was observed. The control group of 35 recently infected patients was 88% and 92% less likely to be infected than the AZD7442 and no-AZD7442 groups. Serum anti-Spike IgG reached the highest peak seven days post-AZD7442 PrEP then decreased, remaining over 1000 BAU/mL 180 days thereafter.ConclusionIn patients with IEI and antibody defects, AZD7442 prophylaxis had a transient protective effect, possibly lost possibly because of the appearance of new variants. However, PrEP with newer mAbs might still represent a feasible preventive strategy in the future in this population.
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- 2023
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7. Decline of gastric cancer mortality in common variable immunodeficiency in the years 2018-2022
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Cinzia Milito, Federica Pulvirenti, Giulia Garzi, Eleonora Sculco, Francesco Cinetto, Davide Firinu, Gianluca Lagnese, Alessandra Punziano, Claudia Discardi, Giulia Costanzo, Carla Felice, Giuseppe Spadaro, Simona Ferrari, and Isabella Quinti
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gastric cancer ,common variable immunodeficiency ,mortality ,endoscopy ,screening ,Helicobacter pylori ,Immunologic diseases. Allergy ,RC581-607 - Abstract
IntroductionIn patients with Common Variable Immunodeficiency, malignancy has been reported as the leading cause of death in adults, with a high risk of B-cell lymphomas and gastric cancer.MethodsWe conducted a five-year prospective study aiming to update the incidence and mortality of gastric cancer and the incidence of gastric precancerous lesions in 512 CVID patients who underwent a total of 400 upper gastrointestinal endoscopies.ResultsIn the pre-pandemic period, 0.58 endoscopies were performed per patient/year and in the COVID-19 period, 0.39 endoscopies were performed per patient/year. Histology revealed areas with precancerous lesions in about a third of patients. Patients who had more than one gastroscopy during the study period were more likely to have precancerous lesions. Two patients received a diagnosis of gastric cancer in the absence of Helicobacter pylori infection. The overall prevalence of Helicobacter pylori infection in biopsy specimens was 19.8% and related only to active gastritis. Among patients who had repeated gastroscopies, about 20% progressed to precancerous lesions, mostly independent of Helicobacter pylori.DiscussionWhile gastric cancer accounted for one in five deaths from CVID in our previous survey, no gastric cancer deaths were recorded in the past five years, likely consistent with the decline in stomach cancer mortality observed in the general population. However, during the COVID-19 pandemic, cancer screening has been delayed. Whether such a delay or true decline could be the reason for the lack of gastric cancer detection seen in CVID may become clear in the coming years. Due to the high incidence of precancerous lesions, we cannot rely on observed and predicted trends in gastric cancer mortality and strongly recommend tailored surveillance programs.
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- 2023
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8. Functional CVIDs phenotype clusters identified by the integration of immune parameters after BNT162b2 boosters
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Eva Piano Mortari, Federica Pulvirenti, Valentina Marcellini, Sara Terreri, Ane Fernandez Salinas, Simona Ferrari, Giulia Di Napoli, Daniele Guadagnolo, Eleonora Sculco, Christian Albano, Marika Guercio, Stefano Di Cecca, Cinzia Milito, Giulia Garzi, Anna Maria Pesce, Livia Bonanni, Matilde Sinibaldi, Veronica Bordoni, Serena Di Cecilia, Silvia Accordini, Concetta Castilletti, Chiara Agrati, Concetta Quintarelli, Salvatore Zaffina, Franco Locatelli, Rita Carsetti, and Isabella Quinti
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CVIDs ,antibodies ,memory B cells ,SARS-CoV-2 ,COVID-19 ,mRNA vaccine ,Immunologic diseases. Allergy ,RC581-607 - Abstract
IntroductionAssessing the response to vaccinations is one of the diagnostic criteria for Common Variable Immune Deficiencies (CVIDs). Vaccination against SARS-CoV-2 offered the unique opportunity to analyze the immune response to a novel antigen. We identify four CVIDs phenotype clusters by the integration of immune parameters after BTN162b2 boosters.MethodsWe performed a longitudinal study on 47 CVIDs patients who received the 3rd and 4th vaccine dose of the BNT162b2 vaccine measuring the generation of immunological memory. We analyzed specific and neutralizing antibodies, spike-specific memory B cells, and functional T cells.ResultsWe found that, depending on the readout of vaccine efficacy, the frequency of responders changes. Although 63.8% of the patients have specific antibodies in the serum, only 30% have high-affinity specific memory B cells and generate recall responses.DiscussionThanks to the integration of our data, we identified four functional groups of CVIDs patients with different B cell phenotypes, T cell functions, and clinical diseases. The presence of antibodies alone is not sufficient to demonstrate the establishment of immune memory and the measurement of the in-vivo response to vaccination distinguishes patients with different immunological defects and clinical diseases.
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- 2023
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9. First WGS Characterization of Streptococcus suis Isolated From a Case of Human Meningitis in Southern Italy.
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Fusco, Giovanna, Dodaro, Saveria, Mauro, Maria Vittoria, Greco, Francesca, Barca, Lorella, Paradiso, Rubina, Limone, Antonio, Garzi Cosentino, Maria, Campione, Agata, De Luca, Giovanna, Cecere, Bianca, Greco, Sonia, Vangeli, Valeria, De Carlo, Esterina, Borriello, Giorgia, Mastroianni, Antonio, and Khurshid, Mohsin
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STREPTOCOCCUS suis ,WHOLE genome sequencing ,GENETIC translation ,GENETIC mutation ,MENINGITIS - Abstract
This study is the first report in Italy on the molecular characterization by whole‐genome sequencing (WGS) analysis of a Streptococcus suis strain isolated from a human case of meningitis in Italy. The characterized S. suis strain was classified as a serotype 2 (SS2), multilocus sequence typing (MLST) sequence type ST1. The strain exhibited the presence of several virulence genes and resistance to penicillin, tetracycline and macrolide–lincosamide–streptogramin. Finally, we found a frameshift mutation in the gene mrp determining the translation of two truncated forms of the corresponding muramidase‐release protein. These results highlight the importance of complete genomic data to understand the pathogenesis and epidemiology of this bacterium, capable to pose serious risks to human health. [ABSTRACT FROM AUTHOR]
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- 2024
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10. Changes in health-related quality of life in common variable immunodeficiency: an eight-year journey, including the COVID-19 pandemic.
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Pulvirenti, Federica, Villa, Annalisa, D'Ambrosi, Matteo, Cusa, Gabriella, Quijada-Morales, Patricia, de la Fuente-Munoz, Eduardo, Sciannamea, Maddalena, Garzi, Giulia, and Quinti, Isabella
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COMMON variable immunodeficiency ,HEALTH impact assessment ,QUALITY of life ,GENERAL Health Questionnaire ,MEDICAL care - Abstract
Background: Personalized medicine requires the assessment of the impact of health care interventions on Health-Related Quality of Life. Research design and methods: We run an observational study of HRQoL in 140 CVID patients with biannual assessments over 8 years using a disease-specific tool, the CVID_QoL, and the GHQ questionnaires. Factors influencing changes in HRQoL scores were identified using multiple linear regression models with a stepwise procedure. Results: Infections frequency, female gender, and chronic enteropathy were associated with worse global CVID_QoL scores. The presence of permanent organ damage and older age contributed to the perception of being at risk of health deterioration, while chronic enteropathy was associated with fatigue. The presence of permanent organ damage was also associated with perceived difficulties in usual activities. The frequency of infections was the main risk factor for difficulties in long-term planning and perceptions of vulnerability. Before COVID-19, improved HRQoL scores were associated with reduced respiratory infections and changes in immunoglobulin replacement route and setting. The COVID-19 pandemic caused a sudden deterioration in all HRQoL dimensions, and a further deterioration in the emotional dimension was observed during the pandemic period. Patients who died during the study had worse CVID_QoL scores at all time points, confirming that HRQoL performance is strongly related to patient outcome. Conclusions: Periodic HRQoL assessments are needed to capture relevant issues that change over time in patients affected by long-term chronic conditions such CVID, possibly identifying areas of intervention. [ABSTRACT FROM AUTHOR]
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- 2024
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11. Struggling with COVID-19 in Adult Inborn Errors of Immunity Patients: A Case Series of Combination Therapy and Multiple Lines of Therapy for Selected Patients
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Patrick Bez, Giancarlo D’ippolito, Carla Maria Deiana, Renato Finco Gambier, Andrea Pica, Giulia Costanzo, Giulia Garzi, Riccardo Scarpa, Nicholas Landini, Francesco Cinetto, Davide Firinu, and Cinzia Milito
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COVID-19 ,SARS-CoV-2 ,IEIs ,antivirals ,monoclonal antibodies ,CVID ,Science - Abstract
Background: The SARS-CoV-2 infection is now a part of the everyday lives of immunocompromised patients, but the choice of treatment and the time of viral clearance can often be complex, exposing patients to possible complications. The role of the available antiviral and monoclonal therapies is a matter of debate, as are their effectiveness and potential related adverse effects. To date, in the literature, the amount of data on the use of combination therapies and on the multiple lines of anti-SARS-CoV-2 therapy available to the general population and especially to inborn error of immunity (IEI) patients is small. Methods: Here, we report a case series of five adult IEI patients managed as inpatients at three Italian IEI referral centers (Rome, Treviso, and Cagliari) treated with combination therapy or multiple therapeutic lines for SARS-CoV-2 infection, such as monoclonal antibodies (mAbs), antivirals, convalescent plasma (CP), mAbs plus antiviral, and CP combined with antiviral. Results: This study may support the use of combination therapy against SARS-CoV-2 in complicated IEI patients with predominant antibody deficiency and impaired vaccine response.
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- 2023
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12. High Prevalence of Long COVID in Common Variable Immunodeficiency:An Italian Multicentric Study
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Villa, Annalisa, Milito, Cinzia, Deiana, Carla Maria, Gambier, Renato Finco, Punziano, Alessandra, Buso, Helena, Bez, Patrick, Lagnese, Gianluca, Garzi, Giulia, Costanzo, Giulia, Giannuzzi, Gloria, Pagnozzi, Chiara, Dalm, Virgil A.S.H., Spadaro, Giuseppe, Rattazzi, Marcello, Cinetto, Francesco, Firinu, Davide, Villa, Annalisa, Milito, Cinzia, Deiana, Carla Maria, Gambier, Renato Finco, Punziano, Alessandra, Buso, Helena, Bez, Patrick, Lagnese, Gianluca, Garzi, Giulia, Costanzo, Giulia, Giannuzzi, Gloria, Pagnozzi, Chiara, Dalm, Virgil A.S.H., Spadaro, Giuseppe, Rattazzi, Marcello, Cinetto, Francesco, and Firinu, Davide
- Abstract
The long-term effects of SARS-CoV-2 infection represent a relevant global health problem. Long COVID (LC) is defined as a complex of signs and symptoms developed during or after SARS-CoV-2 infection and lasting > 12 weeks. In common variable immunodeficiency (CVID) patients, we previously reported higher risk of hospitalization and death during SARS-CoV-2 infection, as well as prolonged swab positivity and frequent reinfections. The aim of the present study was to assess the risk of LC in an Italian cohort of CVID patients. We used a translated version of the survey proposed by Centers for Disease Control and Prevention (CDC) to collect data on LC. In the enrolled cohort of 175 CVID patients, we found a high prevalence of LC (65.7%). The most frequent LC symptoms were fatigue (75.7%), arthralgia/myalgia (48.7%), and dyspnea (41.7%). The majority of patients (60%) experienced prolonged symptoms, for at least 6 months after infection. In a multivariate analysis, the presence of complicated phenotype (OR 2.44, 95% CI 1.88-5.03; p = 0.015), obesity (OR 11.17, 95% CI 1.37-90.95; p = 0.024), and female sex (OR 2.06, 95% CI 1.09-3.89; p = 0.024) significantly correlated with the development of LC. In conclusion, in this multicenter observational cohort study, we demonstrated that CVID patients present an increased prevalence of LC when compared to the general population. Improved awareness on the risk of LC in CVID patients could optimize management of this new and alarming complication of SARS-CoV-2 infection.
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- 2024
13. Real-life data on monoclonal antibodies and antiviral drugs in Italian inborn errors of immunity patients during COVID-19 pandemic
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Giulia Garzi, Francesco Cinetto, Davide Firinu, Giulia Di Napoli, Gianluca Lagnese, Alessandra Punziano, Patrick Bez, Bianca Laura Cinicola, Giulia Costanzo, Riccardo Scarpa, Federica Pulvirenti, Marcello Rattazzi, Giuseppe Spadaro, Isabella Quinti, and Cinzia Milito
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inborn errors of immunity ,COVID-19 ,monoclonal antibodies ,antiviral drugs ,hospitalization-risk ,disease severity ,Immunologic diseases. Allergy ,RC581-607 - Abstract
BackgroundSince the beginning of the COVID-19 pandemic, patients with Inborn Errors of Immunity have been infected by SARS-CoV-2 virus showing a spectrum of disease ranging from asymptomatic to severe COVID-19. A fair number of patients did not respond adequately to SARS-CoV-2 vaccinations, thus early therapeutic or prophylactic measures were needed to prevent severe or fatal course or COVID-19 and to reduce the burden of hospitalizations.MethodsLongitudinal, multicentric study on patients with Inborn Errors of Immunity immunized with mRNA vaccines treated with monoclonal antibodies and/or antiviral agents at the first infection and at reinfection by SARS-CoV-2. Analyses of efficacy were performed according to the different circulating SARS-CoV-2 strains.ResultsThe analysis of the cohort of 192 SARS-CoV-2 infected patients, across 26 months, showed the efficacy of antivirals on the risk of hospitalization, while mabs offered a positive effect on hospitalization, and COVID-19 severity. This protection was consistent across the alpha, delta and early omicron waves, although the emergence of BA.2 reduced the effect of available mabs. Hospitalized patients treated with mabs and antivirals had a lower risk of ICU admission. We reported 16 re-infections with a length of SARS-CoV-2 positivity at second infection shorter among patients treated with mabs. Treatment with antivirals and mabs was safe.ConclusionsThe widespread use of specific therapy, vaccination and better access to care might have contributed to mitigate risk of mortality, hospital admission, and severe disease. However, the rapid spread of new viral strains underlines that mabs and antiviral beneficial effects should be re- evaluated over time.
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- 2022
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14. Health-Related Quality of Life in Common Variable Immunodeficiency Italian Patients Switched to Remote Assistance During the COVID-19 Pandemic
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Pulvirenti, Federica, Cinetto, Francesco, Milito, Cinzia, Bonanni, Livia, Pesce, Anna Maria, Leodori, Giorgia, Garzi, Giulia, Miglionico, Marzia, Tabolli, Stefano, and Quinti, Isabella
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- 2020
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15. Esophageal Atresia of Newborns
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Messina, Mario, Molinaro, Francesco, Garzi, Alfredo, Angotti, Rossella, Buonocore, Giuseppe, editor, Bracci, Rodolfo, editor, and Weindling, Michael, editor
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- 2018
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16. SARS-CoV-2 vaccination in primary antibody deficiencies: an overview on efficacy, immunogenicity, durability of immune response and safety
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Cusa, Gabriella, primary, Sardella, Germano, additional, Garzi, Giulia, additional, Firinu, Davide, additional, and Milito, Cinzia, additional
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- 2023
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17. Decline of gastric cancer mortality in common variable immunodeficiency in the years 2018-2022
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Milito, Cinzia, primary, Pulvirenti, Federica, additional, Garzi, Giulia, additional, Sculco, Eleonora, additional, Cinetto, Francesco, additional, Firinu, Davide, additional, Lagnese, Gianluca, additional, Punziano, Alessandra, additional, Discardi, Claudia, additional, Costanzo, Giulia, additional, Felice, Carla, additional, Spadaro, Giuseppe, additional, Ferrari, Simona, additional, and Quinti, Isabella, additional
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- 2023
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18. Granulomatous Lymphocytic Interstitial Lung Disease (GLILD) in Common Variable Immunodeficiency (CVID): A Multicenter Retrospective Study of Patients From Italian PID Referral Centers
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Francesco Cinetto, Riccardo Scarpa, Maria Carrabba, Davide Firinu, Vassilios Lougaris, Helena Buso, Giulia Garzi, Sabrina Gianese, Valentina Soccodato, Alessandra Punziano, Gianluca Lagnese, Giulio Tessarin, Giulia Costanzo, Nicholas Landini, Stefania Vio, Maria Pia Bondioni, Dario Consonni, Carolina Marasco, Stefano Del Giacco, Marcello Rattazzi, Angelo Vacca, Alessandro Plebani, Giovanna Fabio, Giuseppe Spadaro, Carlo Agostini, Isabella Quinti, and Cinzia Milito
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GLILD ,CVID-ILD ,CD21lo B cells ,splenomegaly ,autoimmune cytopenia ,DLCO ,Immunologic diseases. Allergy ,RC581-607 - Abstract
Background: Granulomatous and Lymphocytic Interstitial Lung Diseases (GLILD) is a severe non-infectious complication of Common Variable Immunodeficiency (CVID), often associated with extrapulmonary involvement. Due to a poorly understood pathogenesis, GLILD diagnosis and management criteria still lack consensus. Accordingly, it is a relevant cause of long-term loss of respiratory function and is closely associated with a markedly reduced survival. The aim of this study was to describe clinical, immunological, laboratory and functional features of GLILD, whose combination in a predictive model might allow a timely diagnosis.Methods: In a multicenter retrospective cross-sectional study we enrolled 73 CVID patients with radiologic features of interstitial lung disease (ILD) associated to CVID (CVID-ILD) and 125 CVID patients without ILD (controls). Of the 73 CVID-ILD patients, 47 received a definite GLILD diagnosis while 26 received a clinical-radiologic diagnosis of CVID related ILD defined as uILD.Results: In GLILD group we found a higher prevalence of splenomegaly (84.8 vs. 39.2%), autoimmune cytopenia (59.6 vs. 6.4%) and bronchiectasis (72.3 vs. 28%), and lower IgA and IgG serum levels at CVID diagnosis. GLILD patients presented lower percentage of switched-memory B cells and marginal zone B cells, and a marked increase in the percentage of circulating CD21lo B cells (14.2 vs. 2.9%). GLILD patients also showed lower total lung capacity (TLC 87.5 vs. 5.0%) and gas transfer (DLCO 61.5 vs. 5.0%) percent of predicted. By univariate logistic regression analysis, we found IgG and IgA levels at CVID diagnosis, presence of splenomegaly and autoimmune cytopenia, CD21lo B cells percentage, TLC and DCLO percent of predicted to be associated to GLILD. The joint analysis of four variables (CD21lo B cells percentage, autoimmune cytopenia, splenomegaly and DLCO percent of predicted), together in a multiple logistic regression model, yielded an area under the ROC curve (AUC) of 0.98 (95% CI: 0.95-1.0). The AUC was only slightly modified when pooling together GLILD and uILD patients (0.92, 95% CI: 0.87-0.97).Conclusions: we propose the combination of two clinical parameters (splenomegaly and autoimmune cytopenia), one lung function index (DLCO%) and one immunologic variable (CD21lo%) as a promising tool for early identification of CVID patients with interstitial lung disease, limiting the use of aggressive diagnostic procedures.
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- 2021
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19. Mortality in Severe Antibody Deficiencies Patients during the First Two Years of the COVID-19 Pandemic: Vaccination and Monoclonal Antibodies Efficacy
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Cinzia Milito, Francesco Cinetto, Andrea Palladino, Giulia Garzi, Alessandra Punziano, Gianluca Lagnese, Riccardo Scarpa, Marcello Rattazzi, Anna Maria Pesce, Federica Pulvirenti, Giulia Di Napoli, Giuseppe Spadaro, Rita Carsetti, and Isabella Quinti
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COVID-19 ,SARS-CoV-2 ,inborn errors of immunity ,antibody deficiency ,incidence ,mortality rate ,Biology (General) ,QH301-705.5 - Abstract
Patients with severely impaired antibody responses represent a group at-risk in the SARS-CoV-2 pandemic due to the lack of Spike-specific neutralizing antibodies. The main objective of this paper was to assess, by a longitudinal prospective study, COVID-19 infection and mortality rates, and disease severity in the first two years of the pandemic in a cohort of 471 Primary Antibody Defects adult patients. As secondary endpoints, we compared SARS-CoV-2 annual mortality rate to that observed over a 10-year follow-up in the same cohort, and we assessed the impact of interventions done in the second year, vaccination and anti-SARS-CoV-2 monoclonal antibodies administration on the disease outcome. Forty-one and 84 patients were infected during the first and the second year, respectively. Despite a higher infection and reinfection rate, and a higher COVID-19-related mortality rate compared to the Italian population, the pandemic did not modify the annual mortality rate for any cause in our cohort compared to that registered over the last ten years in the same cohort. PADs patients who died from COVID-19 had an underlying end-stage lung disease. We showed a beneficial effect of MoAbs administration on the likelihood of hospitalization and development of severe disease. In conclusion, COVID-19 did not cause excess mortality in Severe Antibody Deficiencies.
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- 2022
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20. L’engagement organisationnel dans différents contextes institutionnels : comment les contraintes procédurales perçues entravent l’abnégation
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Giorgio Giacomelli, Milena Vainieri, Rosita Garzi, and Nereo Zamaro
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General Engineering - Published
- 2022
21. Exploring Serum NMR-Based Metabolomic Fingerprint of Colorectal Cancer Patients: Effects of Surgery and Possible Associations with Cancer Relapse
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Alessia Vignoli, Elena Mori, Samantha Di Donato, Luca Malorni, Chiara Biagioni, Matteo Benelli, Vanessa Calamai, Stefano Cantafio, Annamaria Parnofiello, Maddalena Baraghini, Alessia Garzi, Francesca Del Monte, Dario Romagnoli, Ilenia Migliaccio, Claudio Luchinat, Leonardo Tenori, and Laura Biganzoli
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metabolomics ,colorectal cancer ,nuclear magnetic resonance ,surgery ,relapse ,Technology ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Biology (General) ,QH301-705.5 ,Physics ,QC1-999 ,Chemistry ,QD1-999 - Abstract
Background: Colorectal cancer (CRC) is the fourth most commonly diagnosed and third most deadly cancer worldwide. Surgery is the main treatment option for early disease; however, a relevant proportion of CRC patients relapse. Here, variations among preoperative and postoperative serum metabolomic fingerprint of CRC patients were studied, and possible associations between metabolic variations and cancer relapse were explored. Methods: A total of 41 patients with stage I-III CRC, planned for radical resection, were enrolled. Serum samples, collected preoperatively (t0) and 4–6 weeks after surgery before the start of any treatment (t1), were analyzed via NMR spectroscopy. NMR data were analyzed using multivariate and univariate statistical approaches. Results: Serum metabolomic fingerprints show differential clustering between t0 and t1 (82–85% accuracy). Pyruvate, HDL-related parameters, acetone, and 3-hydroxybutyrate appear to be the major players in this discrimination. Eight out of the 41 CRC patients enrolled developed cancer relapse. Postoperative, relapsed patients show an increase of pyruvate and HDL-related parameters, and a decrease of Apo-A1 Apo-B100 ratio and VLDL-related parameters. Conclusions: Surgery significantly alters the metabolomic fingerprint of CRC patients. Some metabolic changes seem to be associated with the development of cancer relapse. These data, if validated in a larger cohort, open new possibilities for risk stratification in patients with early-stage CRC.
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- 2021
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22. Struggling with COVID-19 in Adult Inborn Errors of Immunity Patients: A Case Series of Combination Therapy and Multiple Lines of Therapy for Selected Patients
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Milito, Patrick Bez, Giancarlo D’ippolito, Carla Maria Deiana, Renato Finco Gambier, Andrea Pica, Giulia Costanzo, Giulia Garzi, Riccardo Scarpa, Nicholas Landini, Francesco Cinetto, Davide Firinu, and Cinzia
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COVID-19 ,SARS-CoV-2 ,IEIs ,antivirals ,monoclonal antibodies ,CVID - Abstract
Background: The SARS-CoV-2 infection is now a part of the everyday lives of immunocompromised patients, but the choice of treatment and the time of viral clearance can often be complex, exposing patients to possible complications. The role of the available antiviral and monoclonal therapies is a matter of debate, as are their effectiveness and potential related adverse effects. To date, in the literature, the amount of data on the use of combination therapies and on the multiple lines of anti-SARS-CoV-2 therapy available to the general population and especially to inborn error of immunity (IEI) patients is small. Methods: Here, we report a case series of five adult IEI patients managed as inpatients at three Italian IEI referral centers (Rome, Treviso, and Cagliari) treated with combination therapy or multiple therapeutic lines for SARS-CoV-2 infection, such as monoclonal antibodies (mAbs), antivirals, convalescent plasma (CP), mAbs plus antiviral, and CP combined with antiviral. Results: This study may support the use of combination therapy against SARS-CoV-2 in complicated IEI patients with predominant antibody deficiency and impaired vaccine response.
- Published
- 2023
- Full Text
- View/download PDF
23. Safety of mRNA COVID-19 Vaccines in Patients with Inborn Errors of Immunity: an Italian Multicentric Study
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Cinzia Milito, Francesco Cinetto, Giulia Garzi, Andrea Palladino, Marco Puca, Elena Brambilla, Camilla De Vitis, Giulia Costanzo, Riccardo Scarpa, Alessandra Punziano, Gianluca Lagnese, Stefano Del Giacco, Giuseppe Spadaro, Isabella Quinti, Davide Firinu, Milito, Cinzia, Cinetto, Francesco, Garzi, Giulia, Palladino, Andrea, Puca, Marco, Brambilla, Elena, De Vitis, Camilla, Costanzo, Giulia, Scarpa, Riccardo, Punziano, Alessandra, Lagnese, Gianluca, Del Giacco, Stefano, Spadaro, Giuseppe, Quinti, Isabella, and Firinu, Davide
- Subjects
Vaccines ,Immunology ,CVID ,adverse reaction ,Immunology and Allergy ,COVID-19 ,IEI patients ,immunodeficiency ,safety profile ,IEI patient ,Vaccine - Abstract
Purpose Little is known about vaccine safety in inborn errors of immunity (IEI) patients during the current vaccination campaign for COVID-19. To better investigate the reactogenicity and adverse event profile after two, three, and four doses of mRNA vaccines, we conducted an observational, multicentric study on 342 PID patients from four Italian Referral Centres. Methods We conducted a survey on self-reported adverse reactions in IEI patients who received mRNA vaccine by administering a questionnaire after each dose. Results Over the whole study period, none of the patients needed hospitalization or had hypersensitivity reactions, including anaphylaxis and delayed injection site reaction. After two vaccination doses, 35.4% of patients showed only local reactogenicity-related symptoms (RrS), 44.4% reported both systemic and local RrS, and 5% reported only systemic RrS. In more than 60% of cases, local or systemic RrS were mild. After the first and second booster doses, patients showed fewer adverse events (AEs) than after the first vaccination course. Patients aged 50 years and older reported adverse events and RrS less frequently. Among AEs requiring treatment, one common variable immune deficiency patient affected by T cell large granular lymphocytic leukemia developed neutropenia and one patient had Bell’s paralysis perhaps during herpes zoster reactivation. Conclusion Although our follow-up period is relatively short, the safety data we reported are reassuring. This data would help to contrast the vaccine hesitancy often manifested by patients with IEI and to better inform their healthcare providers.
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- 2023
24. Functional CVIDs phenotype clusters identified by the integration of immune parameters after BNT162b2 boosters
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Piano Mortari, Eva, primary, Pulvirenti, Federica, additional, Marcellini, Valentina, additional, Terreri, Sara, additional, Salinas, Ane Fernandez, additional, Ferrari, Simona, additional, Di Napoli, Giulia, additional, Guadagnolo, Daniele, additional, Sculco, Eleonora, additional, Albano, Christian, additional, Guercio, Marika, additional, Di Cecca, Stefano, additional, Milito, Cinzia, additional, Garzi, Giulia, additional, Pesce, Anna Maria, additional, Bonanni, Livia, additional, Sinibaldi, Matilde, additional, Bordoni, Veronica, additional, Di Cecilia, Serena, additional, Accordini, Silvia, additional, Castilletti, Concetta, additional, Agrati, Chiara, additional, Quintarelli, Concetta, additional, Zaffina, Salvatore, additional, Locatelli, Franco, additional, Carsetti, Rita, additional, and Quinti, Isabella, additional
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- 2023
- Full Text
- View/download PDF
25. Pediatric parenteral nutrition-associated liver disease and cholestasis: Novel advances in pathomechanisms-based prevention and treatment
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Orso, Giuseppe, Mandato, Claudia, Veropalumbo, Claudio, Cecchi, Nicola, Garzi, Alfredo, and Vajro, Pietro
- Published
- 2016
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26. SARS-CoV-2 pre-exposure prophylaxis with tixagevimab/cilgavimab (AZD7442) provides protection in inborn errors of immunity with antibody defects: a real-world experience.
- Author
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Pulvirenti, Federica, Garzi, Giulia, Milito, Cinzia, Sculco, Eleonora, Sciannamea, Maddalena, Napoli, Anna, Cinti, Lilia, Roberto, Piergiorgio, Punziano, Alessandra, Carrabba, Maria, Mortari, Eva Piano, Carsetti, Rita, Antonelli, Guido, and Quinti, Isabella
- Subjects
PRE-exposure prophylaxis ,COVID-19 pandemic ,SARS-CoV-2 ,COMMON variable immunodeficiency ,MONOCLONAL antibodies - Abstract
Background: Preventive strategies against severe COVID-19 in Inborn Errors of Immunity (IEI) include bivalent vaccines, treatment with SARS-CoV-2 monoclonal antibodies (mAbs), early antiviral therapies, and pre-exposure prophylaxis (PrEP). Objective: To assess the effectiveness of the PrEP with tixagevimab/cilgavimab (AZD7442) in IEI with primary antibody defects during the COVID-19 Omicron wave. Methods: A six-month prospective study evaluated the SARS-CoV-2 infection rate and the COVID-19 severity in the AZD7442 group, in the no-AZD7442 group, and in a group of patients with a recent SARS-CoV-2 infection (< three months). Spike-specific IgG levels were measured at regular intervals. Results: Six out of thirty-three patients (18%) and 54/170 patients (32%) became infected in the AZD7442 group and in the no-AZD7442 group, respectively. Within 90 days post-administration, the AZD7442 group was 85% less likely to be infected and 82% less likely to have a symptomatic disease than the no-AZD7442 group. This effect was lost thereafter. In the entire cohort, no mortality/hospitalisation was observed. The control group of 35 recently infected patients was 88% and 92% less likely to be infected than the AZD7442 and no-AZD7442 groups. Serum anti-Spike IgG reached the highest peak seven days post-AZD7442 PrEP then decreased, remaining over 1000 BAU/mL 180 days thereafter. Conclusion: In patients with IEI and antibody defects, AZD7442 prophylaxis had a transient protective effect, possibly lost possibly because of the appearance of new variants. However, PrEP with newer mAbs might still represent a feasible preventive strategy in the future in this population. [ABSTRACT FROM AUTHOR]
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- 2023
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27. Sternal reconstruction by extracellular matrix: a rare case of phaces syndrome
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Molinaro Francesco, Garzi Alfredo, Cerchia Elisa, Di Crescenzo Vincenzo Giuseppe, Luzzi Luca, Bulotta Anna Lavinia, Gotti Giuseppe, and Messina Mario
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Phaces syndrome ,Sternal reconstruction ,Midline development defects ,Medicine - Abstract
Congenital defects of the sternum are rare and due to a failure of midline development and fusion of the sternal bones. Surgical correction of a sternal cleft should be preferred during infancy for functional reasons. Chest wall reconstruction represented a complex problem in the last decades.
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- 2016
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28. Prenatal diagnosis, 3-D virtual rendering and lung sparing surgery by ligasure device in a baby with 'CCAM and intralobar pulmonary sequestration'
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Molinaro Francesco, Angotti Rossella, Garzi Alfredo, Di Crescenzo Vincenzo Giuseppe, Cortese Antonio, and Messina Mario
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lung sparing surgery ,intralobar pulmonary sequestration ,pediatric thoracic surgery ,Medicine - Abstract
Congenital cystic lung lesions are a rare but clinically significant group of anomalies, including congenital cystic adenomatoid malformation (CCAM), pulmonary sequestration, congenital lobar emphysema (CLE) and bronchogenic cysts. Despite the knowledge of these lesions increasing in the last years, some aspects are still debated and controversial. The diagnosis is certainly one aspect which underwent many changes in the last 15 years due to the improvement of antenatal scan and the introduction of 3-D reconstruction techniques. As it is known, a prompt diagnosis has an essential role in the management of these children. The new imaging studies as 3D Volume rendering system are the focus of this paper. We describe our preliminary experience in a case of hybrid lung lesion, which we approached by thoracoscopy after a preoperative study with 3D VR reconstruction. Our final balance is absolutely positive.
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- 2016
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29. The response to BTN62b2 booster doses demonstrates that serum antibodies do not predict the establishment of immune B-cell memory in common variable immune deficiencies
- Author
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Piano Mortari, E., primary, Pulvirenti, F., additional, Marcellini, V., additional, Terreri, S., additional, Fernandez Salinas, A., additional, Ferrari, S., additional, Di Napoli, G., additional, Guadagnolo, D., additional, Sculco, E., additional, Albano, C., additional, Guercio, M., additional, Di Cecca, S., additional, Milito, C., additional, Garzi, G., additional, Pesce, A.M., additional, Bonanni, L., additional, Sinibaldi, M., additional, Di Cecilia, S., additional, Agrati, C., additional, Quintarelli, C., additional, Zaffina, S., additional, Locatelli, F., additional, Carsetti, R., additional, and Quinti, I., additional
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- 2022
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- View/download PDF
30. The response to BTN62b2 booster doses demonstrates that serum antibodies do not predict the establishment of immune B-cell memory in common variable immune deficiencies
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E. Piano Mortari, F. Pulvirenti, V. Marcellini, S. Terreri, A. Fernandez Salinas, S. Ferrari, G. Di Napoli, D. Guadagnolo, E. Sculco, C. Albano, M. Guercio, S. Di Cecca, C. Milito, G. Garzi, A.M. Pesce, L. Bonanni, M. Sinibaldi, S. Di Cecilia, C. Agrati, C. Quintarelli, S. Zaffina, F. Locatelli, R. Carsetti, and I. Quinti
- Abstract
SummaryIn patients with common variable immune deficiencies, primary vaccination followed by two booster doses is recommended for protection against COVID-19. Seroconversion has been shown in 60% of patients. We have no information on whether serum antibodies reflect the generation of durable immune memory.In a longitudinal study on 47 common variable immune deficiencies patients who received the third and fourth vaccine dose, we show that the measurement of specific antibodies is not sufficient to predict the establishment of immune memory and the ability to respond to antigen re-exposure.Our results indicate that the combination of antibodies and memory B cells responses represents a more reliable read-out of vaccine immune efficacy in vulnerable patients.This analysis may not only identify individuals remaining unprotected after vaccination and unable to respond to additional booster doses, but also address the search for the underlying immune defect and suggest patient-tailored management strategies.
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- 2022
31. Esophageal Atresia
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Garzi, Alfredo, Messina, Mario, Buonocore, Giuseppe, editor, Bracci, Rodolfo, editor, and Weindling, Michael, editor
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- 2012
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32. Rare Surgical Emergencies
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Messina, Mario, Molinaro, Francesco, Garzi, Alfredo, Buonocore, Giuseppe, editor, Bracci, Rodolfo, editor, and Weindling, Michael, editor
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- 2012
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33. Professionsentwicklung und Kompetenzen von Lehrpersonen in einer Kultur der Digitalität am Beispiel digi.kompP
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Gerhard Brandhofer, Marlene Miglbauer, Walter Fikisz, Manuel Garzi, Peter Groißböck, Thomas Leitgeb, and Georg Winder
- Abstract
Die Kompetenzen der Lehrenden in Zusammenhang mit der Nutzung von digitalen Medien im Unterricht stehen im Mittelpunkt der Überlegungen in diesem Artikel. Ausgehend von einem Kompetenzmodel (digikompP) gehen wir der Frage nach, wie etabliert dieses Modell ist und in welchen Kontexten das Kompetenzmodell in der Aus-, Fort- und Weiterbildung in Deutschland, Österreich und der Schweiz genutzt wird. Daraus wollen wir im Folgenden herausarbeiten, welche Weiterentwicklungsmöglichkeiten sich daraus ergeben und warum diese aufgegriffen werden sollten.
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- 2022
34. Common and uncommon CT findings in CVID related GL-ILD: correlations with clinical parameters, therapeutic decisions and potential implications in the differential diagnosis
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Riccardo Scarpa, Nicholas Landini, Francesco Cinetto, Cinzia Milito, Sabrina Gianese, Valentina Soccodato, Helena Buso, Giulia Garzi, Maria Carrabba, Emanuele Messina, Valeria Panebianco, Giovanni Morana, Vassilios Lougaris, Carlo Catalano, and Maria Pia Bondioni
- Abstract
Purpose To investigate common and uncommon CT findings in GL-ILD that may be also helpful in differential diagnosis, i.e. with sarcoidosis. To compare CT features with functional and immunological parameters. To look for radiological and non-radiological elements that may be predictive of GL-ILD therapy. Methods We retrospectively described CT features of 38 GL-ILD patients before any specific therapy. Correlations with functional and immunological features were computed. A logistic regression was performed to find a model associated with subsequent GL-ILD therapeutic decisions. Results Most common CT alterations were: bronchiectasis, non-perilymphatic nodules, consolidations, GGO, bands and enlarged mediastinal lymphnodes without calcification. GL-ILD was usually predominant in lower fields. Fibrotic ILD, GGO, reticulations and bronchiectasis were associated with decreased lung performance (pConclusions Most common CT findings in GL-ILD before treatment were small nodules with a non-perilymphatic distribution, consolidations, GGO, bands and bronchiectasis. GL-ILD was usually prevalent in lower fields. A lower fields involvement with non-perylimphatic nodules and a non-traction bronchiectasis pattern could suggest GL-ILD instead of sarcoidosis. MZ B cells percentage, IgA at diagnosis, lower field consolidations and mediastinal lymphnodes enlargement were predictive of a specific GL-ILD therapy.
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- 2022
35. Safety of mRNA COVID-19 Vaccines in Patients with Inborn Errors of Immunity: an Italian Multicentric Study
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Milito, Cinzia, primary, Cinetto, Francesco, additional, Garzi, Giulia, additional, Palladino, Andrea, additional, Puca, Marco, additional, Brambilla, Elena, additional, De Vitis, Camilla, additional, Costanzo, Giulia, additional, Scarpa, Riccardo, additional, Punziano, Alessandra, additional, Lagnese, Gianluca, additional, Del Giacco, Stefano, additional, Spadaro, Giuseppe, additional, Quinti, Isabella, additional, and Firinu, Davide, additional
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- 2022
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36. Professionsentwicklung und Kompetenzen von Lehrpersonen in einer Kultur der Digitalität am Beispiel digi.kompP
- Author
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Brandhofer, Gerhard, primary, Miglbauer, Marlene, additional, Fikisz, Walter, additional, Garzi, Manuel, additional, Groißböck, Peter, additional, Leitgeb, Thomas, additional, and Winder, Georg, additional
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- 2022
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- View/download PDF
37. Common and uncommon CT findings in CVID related GL-ILD: correlations with clinical parameters, therapeutic decisions and potential implications in the differential diagnosis
- Author
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Scarpa, Riccardo, primary, Landini, Nicholas, additional, Cinetto, Francesco, additional, Milito, Cinzia, additional, Gianese, Sabrina, additional, Soccodato, Valentina, additional, Buso, Helena, additional, Garzi, Giulia, additional, Carrabba, Maria, additional, Messina, Emanuele, additional, Panebianco, Valeria, additional, Morana, Giovanni, additional, Lougaris, Vassilios, additional, Catalano, Carlo, additional, and Bondioni, Maria Pia, additional
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- 2022
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38. L’engagement organisationnel dans différents contextes institutionnels : comment les contraintes procédurales perçues entravent l’abnégation
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Giacomelli, Giorgio, primary, Vainieri, Milena, additional, Garzi, Rosita, additional, and Zamaro, Nereo, additional
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- 2022
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39. Pneumoperitoneo
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Garzi, A., Giannotti, G., Messina, M., Esposito, Ciro, Hollands, Celeste, Lima, Mario, Settimi, Alessandro, and Valla, Jean-Stephan
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- 2010
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40. Extrathoracic recurrence of type A thymoma
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Laperuta, Paolo, Napolitano, Filomena, Garzi, Alfredo, Amato, Bruno, Vatrella, Alessandro, and Di Crescenzo, Vincenzo
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- 2014
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41. Small cell lung cancer associated with solitary fibrous tumors of the pleura: A case study and literature review
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Di Crescenzo, Vincenzo, Laperuta, Paolo, Garzi, Alfredo, Napolitano, Filomena, Cascone, Annamaria, and Vatrella, Alessandro
- Published
- 2014
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42. Serum levels of inhibin B in adolescents after varicocelelectomy: A long term follow up
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Molinaro Francesco, Cerchia Elisa, Garzi Alfredo, Severi Francesco Maria, Angotti Rossella, Petraglia Felice, and Messina Mario
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lung sparing surgery ,intralobar pulmonary sequestration ,pediatric thoracic surgery ,Medicine - Abstract
To study the impact on adult’s fertility of serum inhibin B levels in adolescent patients with idiopathic varicocele after minimally invasive surgical correction and to compare fluctuation of pituitary-testis hormonal values and testicular volumes. Materials and Methods: A case-control study was carried out on a group adolescent patients (n=60) affected by idiopathic left varicocele (group V) and compared with control adolescents (n=40) in the Paediatric Surgery Section of Siena (from June 1993 till September 2013). Inhibin B levels and testicular volume before (T0) and after at 6 and 12 months from surgery (T1 and T2) were evaluated. Results: A positive correlation between testicular growth at T1 and T2 (P
- Published
- 2016
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43. Struggling with COVID-19 in Adult Inborn Errors of Immunity Patients: A Case Series of Combination Therapy and Multiple Lines of Therapy for Selected Patients.
- Author
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Bez, Patrick, D'ippolito, Giancarlo, Deiana, Carla Maria, Finco Gambier, Renato, Pica, Andrea, Costanzo, Giulia, Garzi, Giulia, Scarpa, Riccardo, Landini, Nicholas, Cinetto, Francesco, Firinu, Davide, and Milito, Cinzia
- Subjects
CONVALESCENT plasma ,COVID-19 ,MONOCLONAL antibodies ,VACCINE effectiveness ,ADULTS ,CHILD patients - Abstract
Background: The SARS-CoV-2 infection is now a part of the everyday lives of immunocompromised patients, but the choice of treatment and the time of viral clearance can often be complex, exposing patients to possible complications. The role of the available antiviral and monoclonal therapies is a matter of debate, as are their effectiveness and potential related adverse effects. To date, in the literature, the amount of data on the use of combination therapies and on the multiple lines of anti-SARS-CoV-2 therapy available to the general population and especially to inborn error of immunity (IEI) patients is small. Methods: Here, we report a case series of five adult IEI patients managed as inpatients at three Italian IEI referral centers (Rome, Treviso, and Cagliari) treated with combination therapy or multiple therapeutic lines for SARS-CoV-2 infection, such as monoclonal antibodies (mAbs), antivirals, convalescent plasma (CP), mAbs plus antiviral, and CP combined with antiviral. Results: This study may support the use of combination therapy against SARS-CoV-2 in complicated IEI patients with predominant antibody deficiency and impaired vaccine response. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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44. Functional CVIDs phenotype clusters identified by the integration of immune parameters after BNT162b2 boosters.
- Author
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Mortari, Eva Piano, Pulvirenti, Federica, Marcellini, Valentina, Terreri, Sara, Salinas, Ane Fernandez, Ferrari, Simona, Di Napoli, Giulia, Guadagnolo, Daniele, Sculco, Eleonora, Albano, Christian, Guercio, Marika, Di Cecca, Stefano, Milito, Cinzia, Garzi, Giulia, Pesce, Anna Maria, Bonanni, Livia, Sinibaldi, Matilde, Bordoni, Veronica, Di Cecilia, Serena, and Accordini, Silvia
- Subjects
PSYCHONEUROIMMUNOLOGY ,IMMUNOLOGIC memory ,COVID-19 vaccines ,BOOSTER vaccines ,VACCINE effectiveness ,T cells - Abstract
Introduction: Assessing the response to vaccinations is one of the diagnostic criteria for Common Variable Immune Deficiencies (CVIDs). Vaccination against SARS-CoV-2 offered the unique opportunity to analyze the immune response to a novel antigen. We identify four CVIDs phenotype clusters by the integration of immune parameters after BTN162b2 boosters. Methods: We performed a longitudinal study on 47 CVIDs patients who received the 3rd and 4th vaccine dose of the BNT162b2 vaccine measuring the generation of immunological memory. We analyzed specific and neutralizing antibodies, spike-specific memory B cells, and functional T cells. Results: We found that, depending on the readout of vaccine efficacy, the frequency of responders changes. Although 63.8% of the patients have specific antibodies in the serum, only 30% have high-affinity specific memory B cells and generate recall responses. Discussion: Thanks to the integration of our data, we identified four functional groups of CVIDs patients with different B cell phenotypes, T cell functions, and clinical diseases. The presence of antibodies alone is not sufficient to demonstrate the establishment of immune memory and the measurement of the in-vivo response to vaccination distinguishes patients with different immunological defects and clinical diseases. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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45. Real-life data on monoclonal antibodies and antiviral drugs in Italian inborn errors of immunity patients during COVID-19 pandemic
- Author
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Garzi, Giulia, primary, Cinetto, Francesco, additional, Firinu, Davide, additional, Di Napoli, Giulia, additional, Lagnese, Gianluca, additional, Punziano, Alessandra, additional, Bez, Patrick, additional, Cinicola, Bianca Laura, additional, Costanzo, Giulia, additional, Scarpa, Riccardo, additional, Pulvirenti, Federica, additional, Rattazzi, Marcello, additional, Spadaro, Giuseppe, additional, Quinti, Isabella, additional, and Milito, Cinzia, additional
- Published
- 2022
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46. Mortality in Severe Antibody Deficiencies Patients during the First Two Years of the COVID-19 Pandemic: Vaccination and Monoclonal Antibodies Efficacy
- Author
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Milito, Cinzia, primary, Cinetto, Francesco, additional, Palladino, Andrea, additional, Garzi, Giulia, additional, Punziano, Alessandra, additional, Lagnese, Gianluca, additional, Scarpa, Riccardo, additional, Rattazzi, Marcello, additional, Pesce, Anna Maria, additional, Pulvirenti, Federica, additional, Di Napoli, Giulia, additional, Spadaro, Giuseppe, additional, Carsetti, Rita, additional, and Quinti, Isabella, additional
- Published
- 2022
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47. Esophageal Atresia of Newborns
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Messina, M., primary, Molinaro, Francesco, additional, Garzi, Alfredo, additional, and Angotti, Rossella, additional
- Published
- 2016
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48. Exploring Serum NMR-Based Metabolomic Fingerprint of Colorectal Cancer Patients: Effects of Surgery and Possible Associations with Cancer Relapse
- Author
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Matteo Benelli, Elena Mori, Laura Biganzoli, Dario Romagnoli, Stefano Cantafio, Maddalena Baraghini, Francesca Del Monte, Samantha Di Donato, Luca Malorni, Ilenia Migliaccio, Leonardo Tenori, V. Calamai, Alessia Vignoli, Chiara Biagioni, Alessia Garzi, Claudio Luchinat, and A. Parnofiello
- Subjects
medicine.medical_specialty ,Technology ,Colorectal cancer ,QH301-705.5 ,QC1-999 ,Cancer relapse ,colorectal cancer ,surgery ,Metabolomics ,Medicine ,General Materials Science ,In patient ,Stage (cooking) ,Biology (General) ,Instrumentation ,QD1-999 ,Fluid Flow and Transfer Processes ,Nuclear magnetic resonance ,Relapse ,Surgery ,relapse ,business.industry ,Process Chemistry and Technology ,Physics ,General Engineering ,Cancer ,Serum samples ,medicine.disease ,Engineering (General). Civil engineering (General) ,metabolomics ,Computer Science Applications ,nuclear magnetic resonance ,Chemistry ,Cohort ,TA1-2040 ,business - Abstract
Background: Colorectal cancer (CRC) is the fourth most commonly diagnosed and third most deadly cancer worldwide. Surgery is the main treatment option for early disease; however, a relevant proportion of CRC patients relapse. Here, variations among preoperative and postoperative serum metabolomic fingerprint of CRC patients were studied, and possible associations between metabolic variations and cancer relapse were explored. Methods: A total of 41 patients with stage I-III CRC, planned for radical resection, were enrolled. Serum samples, collected preoperatively (t0) and 4–6 weeks after surgery before the start of any treatment (t1), were analyzed via NMR spectroscopy. NMR data were analyzed using multivariate and univariate statistical approaches. Results: Serum metabolomic fingerprints show differential clustering between t0 and t1 (82–85% accuracy). Pyruvate, HDL-related parameters, acetone, and 3-hydroxybutyrate appear to be the major players in this discrimination. Eight out of the 41 CRC patients enrolled developed cancer relapse. Postoperative, relapsed patients show an increase of pyruvate and HDL-related parameters, and a decrease of Apo-A1 Apo-B100 ratio and VLDL-related parameters. Conclusions: Surgery significantly alters the metabolomic fingerprint of CRC patients. Some metabolic changes seem to be associated with the development of cancer relapse. These data, if validated in a larger cohort, open new possibilities for risk stratification in patients with early-stage CRC.
- Published
- 2021
49. Hemangiomas of the maxillofacial area: Case Report, Classification and Treatment Planning
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Cortese Antonio, Pantaleo Giuseppe, D’Alessio Giuseppe, Garzi Alfredo, and Amato Massimo
- Subjects
hemangiomas ,vascular lesion ,sclerotherapy ,Medicine - Abstract
Vascular lesions of the maxillofacial area are even more challenging than in other different body district, because of the high aesthetic and functional relevance of this area for the sense organs presence like eye, brain, tongue, ear and nose. For these reasons, we propose an accurate classification based on hemodynamic and histologic aspects usefulthat is for diagnostic and therapeutic planning. A female, 60 years old patient came to our observation showing a vascular lesion of the lower left lip, and complaining for aesthetical and functional impairment. To confirm the diagnosis of vascular malformation and to detect lesion flow rate or other possible localization, a Tc red blood cell scintigraphy was carried out. Result was a venous low flow lesion; hence, sclerotherapy by a 3% Polidocanol solution (Atossisclerol) followed by surgery was planned. The aim of this work was to propose a diagnostic and therapeutic scheme with an integration of ISSVA and a flow rate classifications for a three-step planning based on 1) the biological findings in an early age at the lesion discover with a pharmacological treatment; 2) Hemodynamic study of the lesions at growing age followed by sclerotherapy or embolization; 3) Imaging study of these lesions for patients candidate to surgery when after step 1 and step 2 diagnostic and therapeutic planning results were incompletely successful.
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- 2015
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50. Evaluation of appendicitis risk prediction models in adults with suspected appendicitis
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Nepogodiev, D., Matthews, J. H., Morley, G. L., Naumann, D. N., Ball, A., Chauhan, P., Bhanderi, S., Mohamed, I., Glasbey, J. C., Wilkin, R. J. W., Drake, T. M., Clements, J., Blencowe, N. S., Herrod, P. J. J., Pata, F., Frasson, M., Blanco-Colino, R., Soares, A. S., Nepogodiev D, Bhangu A., Matthews, Jh, Morley, Gl, Naumann, Dn, Ball, A, Chauhan, P, Bhanderi, S, Mohamed, I, Glasbey, Jc, Wilkin, R, Drake, Tm, Clements, J, Blencowe, Ns, Herrod, P, Pata, F, Frasson, M, Blanco-Colino, R, Soares, As, Bhangu, A, Nepogodiev, D, Jain, S, Amuthalingam, T, Tyler, R, Griffiths, Ea, Pinkney, Td, Gee, O, Morton, Dg, Beggs, A, Beral, D, Bowley, D, Cruickshank, N, Daniels, I, Griffiths, E, Hornby, St, Lund, Jn, Marriott, P, Singh, P, Smart, Nj, Speake, D, Thompson, C, Torkington, J, Torrance, A, Vohra, R, Warren, O, Winter, Dc, Pellino, G, Sgrò, A, Simioni, A, Farina, V, Podda, M, Di Saverio, S, Birindelli, A, Pasquali, S, Itsurg, Surg, Pt, Bolton, W, Bradshaw, Cj, Chean, Cs, Harris, G, Haddow, Jb, Jamieson, Nb, Mccain, S, Mason, J, Milgrom, D, Nana, Gr, Mohamed, Mn, Brien, Jo, Pearce, J, Rabie, M, Sahnan, K, Sarmah, P, Skerritt, C, Ghazanfar, Ma, Sreedharan, L, Kabwama, S, Gray, Rt, Kamande, Iw, Nazarian, S, Dar, Fa, Misky, At, Arunachalam, S, Twum-Barima, Cs, Mohamed, Im, Connor, Kl, Coe, Po, Kosti, A, Elshaer, M, Colvin, Da, Charalambous, Mp, Yeung, K, Merker, L, Morrison, T, Thaventhiran, Aj, Gilbert, Tm, Clements, Jm, Hicks, G, Afshar, S, Mckinley, Nc, Assaf, N, Hanna, T, Macinnes, E, Thavanesan, N, Dubois, As, Palani-Velu, Lk, Tezas, S, Yow, L, Radwan, Rw, Abdelrahman, M, Lee, Ka, Zarka, Za, Mcdowall, Na, Tan, Cy, Venn, Ml, Ashmore, Dl, Whitehorn, Se, Golder, Am, Reddy, A, Delimpalta, C, Kay, Oh, Shah, Sm, Eiben, I, Doyle, C, Tudyka, V, Issa, E, West, H, Brewer, Hk, Farrow, Ez, Taylor, Ns, Smart, Cj, Griffiths, Np, Halkias, C, Vitish-Sharma, P, Knight, Sr, Mowbray, Ng, Olivier, Jb, Lee, Kj, Clement, Kd, Chrastek, D, Panda, N, Connor, Mj, Fahmy, Se, Bryan, Es, Ngu, Ws, Adegbola, So, Vaughan, Em, Stupalkowska, W, Simmonds, L, Malik, A, Hussein, A, Karim, Mj, Singhal, T, Ormiston, R, Kung, V, Rabie, Ma, Park, Jh, Lal, N, Worku, D, D'Auria, M, Ang, A, Orizu, M, Gammeri, E, Clough, E, Choy, Ch, Lawday, S, Hann, Aj, Robinson, D, Wardle, Bg, Mcdonnell, D, Rutherford, Dg, Hickey, Lm, Garg, Ag, Rezvani, S, Bell, Cr, Mahmood, F, Rehman, S, Donaldson, G, Peleki, A, Pearce, L, Sharp, Ol, Singh, S, Thompson, Db, El-Tayar, O, Hollyman, M, Rupasinghe, Sn, Toomey, Db, Murray, Mp, Amtul, N, Mersh, Rj, Newton, Rc, Al-Khyatt, W, Stephens, Gf, Abbas, Sh, Iqbal, Mr, Brown, Ce, Renshaw, S, Hureibi, Ka, Pullabatla-Venkata, Up, Donohoe, No, Myatt, A, Egan, Rj, Rangarajan, K, Trail, M, Mckay, Sc, Engall, N, Jerome, E, Townsend, Dc, Patel, By, Pronin, S, Chandratreya, N, Choong, Jh, Mohamed, Tm, Hudson-Peacock, Nj, Manson, R, Hebbar, K, Mothe, Bs, Weegenaar, Cr, Saad, M, Bowman, Cr, Serventi, F, Fleres, F, Foppa, C, Pata, G, Baronio, G, Pertile, D, Lucchi, A, Sagnotta, A, Maretto, I, Campagnaro, T, Gatti, M, Gjoni, E, Roscio, F, Inama, M, Coccolini, F, Colombo, F, Avanzolini, A, Aresu, S, De-Manzoni-Garberini, A, Merlini, Da, Chessa, A, Tamini, N, Mulas, S, Cillara, N, Coletta, D, Atzeni, J, Erdas, E, Gallo, G, Francone, E, Di Gioia, P, 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Cm, Vargas-Pierola, Hj, Vallve-Bernal, M, Hidalgo-Rosas, Jm, Arenal-Vera, Jj, Sena-Ruiz, F, Sanchez-Guillen, L, Villarejo-Campos, P, Tallon-Aguilar, L, Garcea, A, Bennett, Jm, Whittaker, L, Gidwani, Al, Byrnes, Ck, Saunders, S, Shiwani, Mh, Ashraf, N, Venkatasubramaniam, Ak, Bevan, Ke, Mcarthur, D, Mustafa, Ak, Griffith, Jp, Blazeby, Jm, Charalabopoulos, A, Campbell, W, Reese, G, Warren, Oj, Peacock, M, Menzies, D, Jenner, D, Eardley, Nj, Yoong, S, Abulafi, M, Avalapati, H, Thompson, R, Nastro, P, Kochupapy, R, Stubbs, Bm, Mcintyre, R, Crozier, J, Patel, Pk, Pento, V, Beasley, Wd, Roxburgh, C, Youssef, H, Alexander, R, Denley, S, Di Franco, F, Quddus, A, Saha, A, Hunter, I, Hannay, J, Velchuru, Vr, Bond-Smith, G, Salama, Y, Bhargava, A, Panagiotopoulos, Sp, Watson, N, Garcea, G, Boddy, Ap, Dunning, Pg, Lloyd, G, Gurjar, Sv, Hill, J, Andrews, B, Singh, A, Ruzvidzo, F, Shingler, G, Mahon, D, Elgaddal, S, Payne, Cj, Shaikh, Ia, Dalmia, S, Nair, Ms, Finch, Jg, Chapple, Ks, Bawa, S, Watfah, 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Gulamhussein M., Gaines E., Ghatorae S., Clark S., Savill A., Hutchinson B., Chapman J., Wu F., Creasy W., Raymond M., Grosvenor S., Odeh A., Malik Y., Bansal H., Grant C., Raofi A., Ahmed B., Mai D., Souter J., Hamelmann R.N., Ikram S., Durbacz M., Gilliland N., Salem A., Chudek D., Ladwa N., Storey R., Fontaine C., Toomey D., Miller B., Oakey M., Smoker H., Chapman S.J., O'Hagan S.C., Tahir W., Wilcox G., Ahmad A., Akram F., Baddams T.S., Boshier P.R., Fehervari M., Easdon S., Ilozue T., Adam M.E., Jokhan S., Foster A., Nambiar K., Bohra P., Janardanan S., Shanmuganathan V., Maqboul F., Ettles C., Wardle S.D., Martinou E., Khasria A., Bagga R., Motter D., Mundkur N., Pan Y., Akbari K., Farrell S.M., Rahim A., Gummaraju A., Mahmoud A., Akinsola O., Smallcombe N., Tarazi M., Hanley C., Campbell U.M., Franklin D., Davidson J.R., Raza S.S., Krishnamoorthy A., Rajjoub Y., Ali M., Seddon T.C., Payne R.E., Das A., Martin L.M., Naismith K.N., Venkata U.P., Manda V.M., Burns K.M., Huang J., 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D'Ambra L., Feleppa C., Gennai A., Lizzi V., Moggia E., Imperatore M., Bolzon S., Belvedere A., Amaducci E., Ripoli M.C., Segalini E., Cervellera M., Vaccari S., Eretta C.O., O'Neill R., Llewelyn O., Jones N., Clerici F., Ballabio M., Andolfi E., Angelini M., Fontani A., Miranda E., Scricciolo M., Provenza G., Pellicano G.A., Pulighe F., Argenio G., Melis A., Balestra F., Anania M., Cruccu A., Massaiu C., Murru M.L., Martino A., Luzzi A.P., La Valle G., Chillitupa C.Z., Bartoli A., Conti D., Spaziani A., Bellochi R., Listorti C., Salandini M.C., Carlucci M., Tenconi S.M., Cannavo M., Marano A., Giuffrida M.C., Cannata G., Pellegrino L., Giraudo G., Baraghini M., Garzi A., Giudicissi R., Zalla T., Romoli L., Vannucchi A., Giani I., Feroci F., Calussi M., Ribaudo M., Fiorot A., Stecca T., Nistri C., Fornasier C., Valiani S.V., Brunelli D.B., Evoli L.E., Giuliani N.G., Contine A.C., Renzi C.R., Feo C.V., Anania G., Carcoforo P., Aisoni F., Licari L., Tutino R., Cocorullo G., Silvestri V., De Marco P., Fontana T., Orlando G., Falco N., Baseggio M., Napetti S., Mella A., Rossi G.M., Chimetto A., Cosci M., Bonomo M., Scialandrone G., Chetta N., Carvalho L.C., Magalhaes J.S., Pereira A.M., Fernandes C., Fareleira A., Goncalves D., Pais M., Pereira A., Resende F.M., Correia D., Cardoso D., Tojal A., Santos S.C., Barbosa L., Louro H.C., Bairos F., Martins F.M., Messias F.M., Ferreira M.S., Borges F.C., Botelho P., Lima M., Valente P.M., Joao A.A., Guimaraes J.M., Rocha R., Nogueira S.T., Kabir U., Wong C., Rahmani L.S., Tan S., Chng S., Jasinski B., Cheng S.A., Mardhiah S., McGlynn K., Hannan E., Burke J., Haveliwala Z., O'Neill M., Boland M., Hayes C., Fox A., Zaborowski A., Mitru R.M., Mc-Dermott A., Coyle D., Stoica I., McMahon S.V., Laughlin D.M., Kannegieser-Bailey M., Murphy R., Muntean A., Shet S., Thomas L., De Freitas S., Quill S., Aljorfi A., Soh B., Law J.J., Hartnett J., Jansen T., Gilgan J., Jung J., Scanlon K., Szucs A., Ahern D.P., Redmond A.E., Edwards S.E., Manoharan P., Brennan S., Abdelgadir A.M., Mckevitt K.L., Zarog M.A., Ahmed G., Bukhari W., Ahad A., Paniagua M., Samartin C., Primo J.C., Garrido L., Lopez M., Rufo E., Trostchansky I., Rodriguez L., Infante H., Acosta A., Cremades P., Cidoncha A., Olmos V., Oliva I., Santamaria C., Cavero A., Calvo H., Suero C.A., Maderuelo V.M., Galvez P., Hernando A., Eguaras I., Recreo A.C., Garcia-Carrero M., Moreda R., De Andres U., Del Pozo E., Calvo M., Moratalla C.N., Ronda R.N., Contreras R.G., De Burgos C.B., Cortes G.V., Martinez C.C., Agudo A.R., Soriano J.T., Ramos X.H., Echazarreta E., Elia M., Hernaez A., Sanchez L., Vallejo-Bernad C., Oliver J.R., Sanchez-Rubio M., Kalviainen H.K., Genzor S., Gonzalez-Nicolas T., Puerta E., Laviano E., Gimenez T., Ferminan A., Muriel-Alvarez P., Sierra-Granon J.E., Escoll-Rufino J., Cuello-Guzman E., Mestres-Petit N., Merichal-Resina M., Pinillos-Somalo A., Gomez-Carmona Z., Vazquez-Fernandez A.P., Trujillo-Diaz J.J., Couso J.R., Fernandez M.D., Riera E., Espinosa J., Carral-Freire M., Martinez-Almeida R., Santarrufina-Martinez S., Sebastian-Tomas J.C., Gonzalvez-Guardiola P., Fernandez E.C., Mozo A.S., Stoyanov T.I., Santamaria P.C., Grimaldo E.G., Fernandez-Candela A., Curtis-Martinez C., Del-Valle-Ruiz S.R., Sanchez-Cifuentes A., Ramirez-Faraco M., Lopez A.F., Leon C., Kumar S., Fornell-Ariza M., Ayllon-Gamez S., Pena-Barturen C., Ojea-Ruiz-Yherla L., Saavedra-Chacon M., Perez-Calvo J., Gomez-Facundo H., Riba-Combatti L., Manas O.C., De-Soto-Cardenal B., De-La-Herranz-Guerrero P., Dominguez-Sanchez C., Gamero-Huaman J.C., Suarez-Cabrera A., Ramirez-Redondo A.A., Lara-Fernandez Y., Bascuas-Rodrigo B., Lopez-Duran B.L., Pigem A., Gil J., Salvador H., Planellas P., Farres R., Caballero A., Arnau M., Tapiolas I., Ridaura N., Roncero L.S., Collado-Roura F., Fijo L.M., Cormenzana O.B., Vinas N.L., Grifell M.S., Prats M.A., Torrado A.A., Sanz-Navarro S., Contreras-Saiz E., Solar-Garcia L., Moreno-Gijon M., Suarez-Sanchez A., Diaz-Vico T., Rodicio-Miravalles J.L., Garcia-Gutierrez C., Pila U., Melone S., Martin-Prieto L., Rojo J.A., Gonzalez M., Zorrilla L., Garcia-Marin J.A., Baeza-Murcia M., Pellicer-Franco E., Jimenez-Ballester M.A., Asensio-Gomez L., Gortazar-De-Las-Casas S., Guevara-Martinez J., Ramirez L., Verea S., Anguita F., Navarro G., Criado ADC., Lara M.C., Martinez E.T., Sanchez-Martinez A., Hernandez-Gimenez L., Galofre-Recasens M., Ferrer-Vilela I., Perez-Sanchez L.E., Esteves M.B., Menendez-Moreno A., Baz-Figueroa C., Rosat A., Hontoria M.S., Garcia N.A., Gracia-Roman R., Pascua-Sole M., Pino-Perez O., Garcia-Perez J.M., Pineno-Flores C., Ambrona-Zafra D., Sancho-Muriel J., Alvarez E., Jimenez-Rosellon R., Daga O., Alberca-Paramo A., Sanchez-Garcia S., Garcia-Santos E., Pareja-Ciuro F., Olivares-Oliver C., Navarro-Morales L., Tamayo-Lopez M.J., Tinoco-Gonzalez J., Garcia-Rivera C.O., Agua I.A., Moreno-Suero F., Pereira-Mosquera E., Zerpa C., Llacer E., Diaz A., Caro A., Feliu F., Franco M., Escuder J., Abellan M., Padilla E., Mambrilla-Herrero S., Plua-Muniz K.T., Bailon-Cuadrado M., Tejero-Pintor F.J., Choolani-Bhojwani E., Vila-Zarate C., Delgado-Plasencia L.J., Ponchietti L., Cousins L., Busuttil A., Baird C., Drye N., Brown O.D., Mansour S., Anderson O., Mahapatra R., Clements J.A., D'Souza N., Littlehales D.J., Tang A.M., Byrne B.E., Cunha P., Ogbuokiri C., Eiben P., Gravante G., Kho H., Dobbs S., Doulias T., Ng J., Wilson M., Venugopal R., Wolff J., Akhtar K., Walji H.D., Tognarelli J.M., Knight K.A., Ansari A., Hussaini S.A., Wright E., Brewer H., Rinkoff S., Harries R.L., Fairfield C.J., Abbott T., Jackson A., Wright H.L., Walters U., Carney K., Logan P.C., Mughal Z., Strachan E., Chasty B., Ma J., Mazzeo C., Badii B., Armellini A., Grassia M., Perin A., Ruzzenente A., Magnoli M., Depalma N., Longheu A., Papandrea M., Dova L., De Prizio M., Gusai G.P., Di Zitti L., Geretto P., Azabdaftari A., Chianese G., Elbetti C., Ruffolo C., Giaccari S., Devezas V., Ferreira J.S., Peixoto R., Alshafei A., Simo V., Jose H.S., Ugarte-Sierra B., Salva A.B., Gomez N., Marinello F., Medina-Arana V., Vega L., Ballester M.M., Espina B., Prieto-Nieto M.I., Rodriguez E.C., Padilla-Valverde D., and Duran-Munoz-Cruzado V.M.
- Subjects
Adult ,humanos ,Decision Making ,Risk Assessment ,NO ,apendicectomía ,apendicitis ,evaluación de riesgos ,Appendectomy ,Humans ,hospital ,General ,collaborative ,LS7_4 ,right iliac fossa ,appendicitis ,emergency service ,Original Articles ,adulto ,Appendicitis ,adult ,appendectomy ,humans ,risk assessment ,decision making ,Lower GI ,Original Article ,appendicitis, prediction models, right iliac fossa pain ,Emergency Service, Hospital ,toma de decisión - Abstract
Background Appendicitis is the most common general surgical emergency worldwide, but its diagnosis remains challenging. The aim of this study was to determine whether existing risk prediction models can reliably identify patients presenting to hospital in the UK with acute right iliac fossa (RIF) pain who are at low risk of appendicitis. Methods A systematic search was completed to identify all existing appendicitis risk prediction models. Models were validated using UK data from an international prospective cohort study that captured consecutive patients aged 16–45 years presenting to hospital with acute RIF in March to June 2017. The main outcome was best achievable model specificity (proportion of patients who did not have appendicitis correctly classified as low risk) whilst maintaining a failure rate below 5 per cent (proportion of patients identified as low risk who actually had appendicitis). Results Some 5345 patients across 154 UK hospitals were identified, of which two‐thirds (3613 of 5345, 67·6 per cent) were women. Women were more than twice as likely to undergo surgery with removal of a histologically normal appendix (272 of 964, 28·2 per cent) than men (120 of 993, 12·1 per cent) (relative risk 2·33, 95 per cent c.i. 1·92 to 2·84; P, Women in the UK had a disproportionate risk of admission without surgical intervention and had high rates of normal appendicectomy. Risk prediction models to support shared decision‐making were identified by identifying UK adults at low risk of appendicitis. An online calculator is available (http://appy-risk.org). WCC, white cell count; CRP, C‐reactive protein; AIRS, Appendicitis Inflammatory Response Score; AAS, Adult Appendicitis Score. Important differences between men and women
- Published
- 2019
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