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1. Infectious disease events in people with HIV receiving kidney transplantation: Analysis of the Swiss HIV Cohort Study and the Swiss Transplant Cohort Study

Author

Kusejko, Katharina, Kouyos, Roger D., Bernasconi, Enos, Boggian, Katia, Braun, Dominique L., Calmy, Alexandra, Cavassini, Matthias, van Delden, Christian, Furrer, Hansjakob, Garzoni, Christian, Hirsch, Hans H., Hirzel, Cedric, Manuel, Oriol, Schmid, Patrick, Khanna, Nina, Haidar, Fadi, Bonani, Marco, Golshayan, Dela, Dickenmann, Michael, Sidler, Daniel, Schnyder, Aurelia, Mueller, Nicolas J., Günthard, Huldrych F., and Schreiber, Peter W.

Published
2024
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3. Neutralization, effector function and immune imprinting of Omicron variants

Author

Addetia, Amin, Piccoli, Luca, Case, James Brett, Park, Young-Jun, Beltramello, Martina, Guarino, Barbara, Dang, Ha, de Melo, Guilherme Dias, Pinto, Dora, Sprouse, Kaitlin, Scheaffer, Suzanne M., Bassi, Jessica, Silacci-Fregni, Chiara, Muoio, Francesco, Dini, Marco, Vincenzetti, Lucia, Acosta, Rima, Johnson, Daisy, Subramanian, Sambhavi, Saliba, Christian, Giurdanella, Martina, Lombardo, Gloria, Leoni, Giada, Culap, Katja, McAlister, Carley, Rajesh, Anushka, Dellota, Jr, Exequiel, Zhou, Jiayi, Farhat, Nisar, Bohan, Dana, Noack, Julia, Chen, Alex, Lempp, Florian A., Quispe, Joel, Kergoat, Lauriane, Larrous, Florence, Cameroni, Elisabetta, Whitener, Bradley, Giannini, Olivier, Cippà, Pietro, Ceschi, Alessandro, Ferrari, Paolo, Franzetti-Pellanda, Alessandra, Biggiogero, Maira, Garzoni, Christian, Zappi, Stephanie, Bernasconi, Luca, Kim, Min Jeong, Rosen, Laura E., Schnell, Gretja, Czudnochowski, Nadine, Benigni, Fabio, Franko, Nicholas, Logue, Jennifer K., Yoshiyama, Courtney, Stewart, Cameron, Chu, Helen, Bourhy, Hervé, Schmid, Michael A., Purcell, Lisa A., Snell, Gyorgy, Lanzavecchia, Antonio, Diamond, Michael S., Corti, Davide, and Veesler, David

Published
2023
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4. Surgical site infections after kidney transplantation are independently associated with graft loss

Author

Amico, Patrizia, Aubert, John-David, Banz, Vanessa, Beckmann, Sonja, Beldi, Guido, Berger, Christoph, Berishvili, Ekaterine, Berzigotti, Annalisa, Binet, Isabelle, Bochud, Pierre-Yves, Branca, Sanda, Bucher, Heiner, Catana, Emmanuelle, Cairoli, Anne, Chalandon, Yves, De Geest, Sabina, De Rougemont, Olivier, De Seigneux, Sophie, Dickenmann, Michael, Dreifuss, Joëlle Lynn, Duchosal, Michel, Fehr, Thomas, Ferrari-Lacraz, Sylvie, Garzoni, Christian, Golshayan, Déla, Goossens, Nicolas, Haidar, Fadi, Halter, Jörg, Heim, Dominik, Hess, Christoph, Hillinger, Sven, Hirsch, Hans H., Hirt, Patricia, Hoessly, Linard, Hofbauer, Günther, Huynh-Do, Uyen, Immer, Franz, Koller, Michael, Laesser, Bettina, Lamoth, Frédéric, Lehmann, Roger, Leichtle, Alexander, Manuel, Oriol, Marti, Hans-Peter, Martinelli, Michele, McLin, Valérie, Mellac, Katell, Merçay, Aurélia, Mettler, Karin, Mueller, Nicolas J., Müller-Arndt, Ulrike, Müllhaupt, Beat, Nägeli, Mirjam, Oldani, Graziano, Pascual, Manuel, Passweg, Jakob, Pazeller, Rosemarie, Posfay-Barbe, Klara, Rick, Juliane, Rosselet, Anne, Rossi, Simona, Rothlin, Silvia, Ruschitzka, Frank, Schachtner, Thomas, Schaub, Stefan, Scherrer, Alexandra, Schnyder, Aurelia, Schuurmans, Macé, Schwab, Simon, Sengstag, Thierry, Simonetta, Federico, Stampf, Susanne, Steiger, Jürg, Stirnimann, Guido, Stürzinger, Ueli, Van Delden, Christian, Venetz, Jean-Pierre, Villard, Jean, Vionnet, Julien, Wick, Madeleine, Wilhelm, Markus, Yerly, Patrick, Schreiber, Peter W., Hoessly, Linard D., Boggian, Katia, Neofytos, Dionysios, van Delden, Christian, Egli, Adrian, Hirzel, Cédric, Schmied, Bruno, Guerke, Lorenz, Matter, Maurice, de Rougemont, Olivier, Bonani, Marco, Sidler, Daniel, and Kuster, Stefan P.

Published
2024
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5. Reintegration Into the Workforce After Kidney Transplantation Based on Urbanization Status in Switzerland

Author

Amico, Patrizia, Bachofner, Adrian, Banz, Vanessa, Beckmann, Sonja, Beldi, Guido, Berger, Christoph, Berishvili, Ekaterine, Berzigotti, Annalisa, Bochud, Pierre-Yves, Branca, Sanda, Bucher, Heiner, Cairoli, Anne, Catana, Emmanuelle, Chalandon, Yves, De Geest, Sabina, De Seigneux, Sophie, Dickenmann, Michael, Dreifuss, Joëlle Lynn, Duchosal, Michel, Fehr, Thomas, Ferrari-Lacraz, Sylvie, Frossard, Jaromil, Garzoni, Christian, Golshayan, Déla, Goossens, Nicolas, Haidar, Fadi, Halter, Jörg, Heim, Dominik, Hess, Christoph, Hillinger, Sven, Hirsch, Hans, Hirt, Patricia, Hoessly, Linard, Hofbauer, Günther, Huynh-Do, Uyen, Immer, Franz, Koller, Michael, Kremer, Andreas, Krueger, Thorsten, Kuhn, Christian, Laesser, Bettina, Lamoth, Frédéric, Lehmann, Roger, Leichtle, Alexander, Manuel, Oriol, Marti, Hans-Peter, Martinelli, Michele, McLin, Valérie, Mellac, Katell, Merçay, Aurélia, Mettler, Karin, Müller, Nicolas, Müller-Arndt, Ulrike, Müllhaupt, Beat, Nägeli, Mirjam, Oldani, Graziano, Pascual, Manuel, Passweg, Jakob, Pazeller, Rosemarie, Posfay-Barbe, Klara, Reineke, David, Rick, Juliane, Rosselet, Anne, Rossi, Simona, Rössler, Rothlin, Silvia, Ruschitzka, Frank, Schachtner, Thomas, Schaub, Stefan, Scherrer, Alexandra, Schneidawind, Dominik, Schnyder, Aurelia, Schuurmans, Macé, Schwab, Simon, Sengstag, Thierry, Simonetta, Federico, Steiger, Jürg, Stirniman, Guido, Stürzinger, Ueli, Van Delden, Christian, Venetz, Jean-Pierre, Villard, Jean, Vionnet, Julien, Wick, Madeleine, Wilhlem, Markus, Yerly, Patrick, Bocchi, Federica, Müller, Selina, Binet, Isabelle, Golshayan, Dela, Müller, Thomas, Sidler, Daniel, and Storni, Federico

Published
2024
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6. Outcome of Patients Transplanted for C3 Glomerulopathy and Primary Immune Complex-Mediated Membranoproliferative Glomerulonephritis

Author

Amico, Patrizia, Aubert, John-David, Banz, Vanessa, Beckmann, Sonia, Beldi, Guido, Berger, Christoph, Berishvili, Ekaterine, Binet, Isabelle, Bochud, Pierre-Yves, Branca, Sanda, Bucher, Heiner, Catana, Emmanuelle, Chalandon, Yves, De Geest, Sabina, De Seigneux Michael Dickenmann, Sophie, Dreifuss, Joëlle Lynn, Duchosal, Michel, Fehr, Thomas, Ferrari-Lacraz, Sylvie, Garzoni, Christian, Gaudet, Christophe, Golshayan, Déla, Goossens, Nicolas, Halter, Jörg, Heim, Dominik, Hess, Christoph, Hillinger, Sven, Hirsch, Hans H., Hirt, Patricia, Hofbauer, Günther, Huynh-Do, Uyen, Immer, Franz, Koller, Michael, Laager, Mirjam, Laesser, Bettina, Lamoth, Frédéric, Lehmann, Roger, Leichtle, Alexander, Manuel, Oriol, Marti, Hans-Peter, Martinelli, Michele, McLin, Valérie, Mellac, Katell, Mercay, Aurelia, Mettler, Karin, Mueller, Nicolas J., Müller, Antonia, Müller-Arndt, Ulrike, Müllhaupt, Beat, Nägeli, Mirjam, Oldani, Graziano, Pascual, Manuel, Passweg, Jakob, Posfay-Barbe, Klara, Rick, Juliane, Rosselet, Anne, Rossi, Simona, Rothlin, Silvia, Ruschitzka, Frank, Schachtner, Thomas, Schanz, Urs, Schaub, Stefan, Schwab, Simon, Schnyder, Aurelia, Schuurmans, Macé, Sengstag, Thierry, Simonetta, Federico, Steiger, Jürg, Stirniman, Guido, Stürzinger, Ueli, Van Delden, Christian, Venetz, Jean-Pierre, Villard, Jean, Vionnet, Julien, Wick, Madeleine, Wilhlem, Markus, Yerly, Patrick, Halfon, Matthieu, Taffé, Patrick, Bucher, Christian, Haidar, Fadi, Huynh-do, Uyen, Mani, Laila-Yasmin, Wehmeier, Caroline, Fakhouri, Fadi, and Golshayan, Dela

Published
2024
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7. Autoantibodies against chemokines post-SARS-CoV-2 infection correlate with disease course

Author

Muri, Jonathan, Cecchinato, Valentina, Cavalli, Andrea, Shanbhag, Akanksha A., Matkovic, Milos, Biggiogero, Maira, Maida, Pier Andrea, Moritz, Jacques, Toscano, Chiara, Ghovehoud, Elaheh, Furlan, Raffaello, Barbic, Franca, Voza, Antonio, De Nadai, Guendalina, Cervia, Carlo, Zurbuchen, Yves, Taeschler, Patrick, Murray, Lilly A., Danelon-Sargenti, Gabriela, Moro, Simone, Gong, Tao, Piffaretti, Pietro, Bianchini, Filippo, Crivelli, Virginia, Podešvová, Lucie, Pedotti, Mattia, Jarrossay, David, Sgrignani, Jacopo, Thelen, Sylvia, Uhr, Mario, Bernasconi, Enos, Rauch, Andri, Manzo, Antonio, Ciurea, Adrian, Rocchi, Marco B. L., Varani, Luca, Moser, Bernhard, Bottazzi, Barbara, Thelen, Marcus, Fallon, Brian A., Boyman, Onur, Mantovani, Alberto, Garzoni, Christian, Franzetti-Pellanda, Alessandra, Uguccioni, Mariagrazia, and Robbiani, Davide F.

Published
2023
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8. Circulating SARS-CoV-2 spike N439K variants maintain fitness while evading antibody-mediated immunity

Author

Thomson, Emma C, Rosen, Laura E, Shepherd, James G, Spreafico, Roberto, da Silva Filipe, Ana, Wojcechowskyj, Jason A, Davis, Chris, Piccoli, Luca, Pascall, David J, Dillen, Josh, Lytras, Spyros, Czudnochowski, Nadine, Shah, Rajiv, Meury, Marcel, Jesudason, Natasha, De Marco, Anna, Li, Kathy, Bassi, Jessica, O’Toole, Aine, Pinto, Dora, Colquhoun, Rachel M, Culap, Katja, Jackson, Ben, Zatta, Fabrizia, Rambaut, Andrew, Jaconi, Stefano, Sreenu, Vattipally B, Nix, Jay, Zhang, Ivy, Jarrett, Ruth F, Glass, William G, Beltramello, Martina, Nomikou, Kyriaki, Pizzuto, Matteo, Tong, Lily, Cameroni, Elisabetta, Croll, Tristan I, Johnson, Natasha, Di Iulio, Julia, Wickenhagen, Arthur, Ceschi, Alessandro, Harbison, Aoife M, Mair, Daniel, Ferrari, Paolo, Smollett, Katherine, Sallusto, Federica, Carmichael, Stephen, Garzoni, Christian, Nichols, Jenna, Galli, Massimo, Hughes, Joseph, Riva, Agostino, Ho, Antonia, Schiuma, Marco, Semple, Malcolm G, Openshaw, Peter JM, Fadda, Elisa, Baillie, J Kenneth, Chodera, John D, Investigators, The ISARIC4C, Consortium, the COVID-19 Genomics UK, Rihn, Suzannah J, Lycett, Samantha J, Virgin, Herbert W, Telenti, Amalio, Corti, Davide, Robertson, David L, and Snell, Gyorgy

Subjects
Medical Microbiology, Biomedical and Clinical Sciences, Biological Sciences, Immunology, Pneumonia, Prevention, Infectious Diseases, Vaccine Related, Immunization, Pneumonia & Influenza, Biodefense, Biotechnology, Emerging Infectious Diseases, Lung, 2.1 Biological and endogenous factors, Aetiology, Infection, Good Health and Well Being, Angiotensin-Converting Enzyme 2, Antibodies, Neutralizing, Antibodies, Viral, COVID-19, Genetic Fitness, Humans, Immune Evasion, Mutation, Phylogeny, SARS-CoV-2, Spike Glycoprotein, Coronavirus, Virulence, ISARIC4C Investigators, COVID-19 Genomics UK (COG-UK) Consortium, N439K, Spike, monoclonal antibody escape, mutation, protein structure, receptor binding motif, variant, Medical and Health Sciences, Developmental Biology, Biological sciences, Biomedical and clinical sciences
Abstract

SARS-CoV-2 can mutate and evade immunity, with consequences for efficacy of emerging vaccines and antibody therapeutics. Here, we demonstrate that the immunodominant SARS-CoV-2 spike (S) receptor binding motif (RBM) is a highly variable region of S and provide epidemiological, clinical, and molecular characterization of a prevalent, sentinel RBM mutation, N439K. We demonstrate N439K S protein has enhanced binding affinity to the hACE2 receptor, and N439K viruses have similar in vitro replication fitness and cause infections with similar clinical outcomes as compared to wild type. We show the N439K mutation confers resistance against several neutralizing monoclonal antibodies, including one authorized for emergency use by the US Food and Drug Administration (FDA), and reduces the activity of some polyclonal sera from persons recovered from infection. Immune evasion mutations that maintain virulence and fitness such as N439K can emerge within SARS-CoV-2 S, highlighting the need for ongoing molecular surveillance to guide development and usage of vaccines and therapeutics.

Published
2021

9. Bloodstream infections in allogeneic haematopoietic cell recipients from the Swiss Transplant Cohort Study: trends of causative pathogens and resistance rates

Author

Sava, Mihaela, Bättig, Veronika, Gerull, Sabine, Passweg, Jakob R., Khanna, Nina, Garzoni, Christian, Gerber, Bernhard, Mueller, Nicolas J., Schanz, Urs, Berger, Christoph, Chalandon, Yves, van Delden, Christian, Neofytos, Dionysios, Stampf, Susanne, Franzeck, Fabian C., and Weisser, Maja

Published
2023
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10. Mapping Neutralizing and Immunodominant Sites on the SARS-CoV-2 Spike Receptor-Binding Domain by Structure-Guided High-Resolution Serology

Author

Piccoli, Luca, Park, Young-Jun, Tortorici, M Alejandra, Czudnochowski, Nadine, Walls, Alexandra C, Beltramello, Martina, Silacci-Fregni, Chiara, Pinto, Dora, Rosen, Laura E, Bowen, John E, Acton, Oliver J, Jaconi, Stefano, Guarino, Barbara, Minola, Andrea, Zatta, Fabrizia, Sprugasci, Nicole, Bassi, Jessica, Peter, Alessia, De Marco, Anna, Nix, Jay C, Mele, Federico, Jovic, Sandra, Rodriguez, Blanca Fernandez, Gupta, Sneha V, Jin, Feng, Piumatti, Giovanni, Lo Presti, Giorgia, Pellanda, Alessandra Franzetti, Biggiogero, Maira, Tarkowski, Maciej, Pizzuto, Matteo S, Cameroni, Elisabetta, Havenar-Daughton, Colin, Smithey, Megan, Hong, David, Lepori, Valentino, Albanese, Emiliano, Ceschi, Alessandro, Bernasconi, Enos, Elzi, Luigia, Ferrari, Paolo, Garzoni, Christian, Riva, Agostino, Snell, Gyorgy, Sallusto, Federica, Fink, Katja, Virgin, Herbert W, Lanzavecchia, Antonio, Corti, Davide, and Veesler, David

Subjects
Medical Microbiology, Biomedical and Clinical Sciences, Immunology, Clinical Research, Lung, Pneumonia & Influenza, Biodefense, Immunization, Prevention, Infectious Diseases, Pneumonia, Vaccine Related, Emerging Infectious Diseases, Infection, Good Health and Well Being, Angiotensin-Converting Enzyme 2, Antibodies, Monoclonal, Antibodies, Neutralizing, Antibodies, Viral, Antigen-Antibody Reactions, Betacoronavirus, Binding Sites, COVID-19, Coronavirus Infections, Epitope Mapping, Epitopes, Humans, Immunoglobulin A, Immunoglobulin G, Immunoglobulin M, Kinetics, Molecular Dynamics Simulation, Pandemics, Peptidyl-Dipeptidase A, Pneumonia, Viral, Protein Binding, Protein Domains, Protein Structure, Quaternary, SARS-CoV-2, Spike Glycoprotein, Coronavirus, coronaviruses, effector functions, immunity, neutralizing antibodies, Biological Sciences, Medical and Health Sciences, Developmental Biology, Biological sciences, Biomedical and clinical sciences
Abstract

Analysis of the specificity and kinetics of neutralizing antibodies (nAbs) elicited by SARS-CoV-2 infection is crucial for understanding immune protection and identifying targets for vaccine design. In a cohort of 647 SARS-CoV-2-infected subjects, we found that both the magnitude of Ab responses to SARS-CoV-2 spike (S) and nucleoprotein and nAb titers correlate with clinical scores. The receptor-binding domain (RBD) is immunodominant and the target of 90% of the neutralizing activity present in SARS-CoV-2 immune sera. Whereas overall RBD-specific serum IgG titers waned with a half-life of 49 days, nAb titers and avidity increased over time for some individuals, consistent with affinity maturation. We structurally defined an RBD antigenic map and serologically quantified serum Abs specific for distinct RBD epitopes leading to the identification of two major receptor-binding motif antigenic sites. Our results explain the immunodominance of the receptor-binding motif and will guide the design of COVID-19 vaccines and therapeutics.

Published
2020

11. Maturation of SARS-CoV-2 Spike-specific memory B cells drives resilience to viral escape

Author

Marzi, Roberta, Bassi, Jessica, Silacci-Fregni, Chiara, Bartha, Istvan, Muoio, Francesco, Culap, Katja, Sprugasci, Nicole, Lombardo, Gloria, Saliba, Christian, Cameroni, Elisabetta, Cassotta, Antonino, Low, Jun Siong, Walls, Alexandra C., McCallum, Matthew, Tortorici, M. Alejandra, Bowen, John E., Dellota, Exequiel A., Jr., Dillen, Josh R., Czudnochowski, Nadine, Pertusini, Laura, Terrot, Tatiana, Lepori, Valentino, Tarkowski, Maciej, Riva, Agostino, Biggiogero, Maira, Franzetti-Pellanda, Alessandra, Garzoni, Christian, Ferrari, Paolo, Ceschi, Alessandro, Giannini, Olivier, Havenar-Daughton, Colin, Telenti, Amalio, Arvin, Ann, Virgin, Herbert W., Sallusto, Federica, Veesler, David, Lanzavecchia, Antonio, Corti, Davide, and Piccoli, Luca

Published
2023
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13. The MELD upgrade exception: a successful strategy to optimize access to liver transplantation for patients with high waiting list mortality

Author

Amico, Patrizia, Axel, Andres, Aubert, John-David, Banz, Vanessa, Sonja, Beckmann, Beldi, Guido, Benden, Christian, Berger, Christoph, Binet, Isabelle, Bochud, Pierre-Yves, Branca, Sanda, Bucher, Heiner, Carrel, Thierry, Catana, Emmanuelle, Chalandon, Yves, de Geest, Sabina, de Rougemont, Olivier, Dickenmann, Michael, Dreifuss, Joëlle L., Duchosal, Michel, Fehr, Thomas, Ferrari-Lacraz, Sylvie, Garzoni, Christian, Soccal, Paola G., Gaudet, Christophe, Giostra, Emiliano, Golshayan, Déla, Hadaya, Karine, Halter, Jörg, Hauri, Dimitri, Heim, Dominik, Hess, Christoph, Hillinger, Sven, Hirsch, Hans, Hirt, Patricia, Hofbauer, Günther, Huynh-Do, Uyen, Immer, Franz, Koller, Michael, Laesser, Bettina, Lang, Brian, Lehmann, Roger, Leichtle, Alexander, Lovis, Christian, Manuel, Oriol, Marti, Hans-Peter, Martin, Pierre Y., Martinelli, Michele, Mellac, Katell, Merçay, Aurélia, Mettler, Karin, Meylan, Pascal, Mueller, Nicolas, Müller, Antonia, Müller, Thomas, Müller-Arndt, Ulrike, Müllhaupt, Beat, Nägeli, Mirjam, Pascual, Manuel, Posfay-Barbe, Klara, Rick, Juliane, Rosselet, Anne, Rossi, Simona, Rothlin, Silvia, Ruschitzka, Frank, Schanz, Urs, Schaub, Stefan, Schnyder, Aurelia, Schuurmans, Macé, Simonetta, Federico, Staufer, Katharina, Stampf, Susanne, Steiger, Jürg, Stirniman, Guido, Stürzinger, Ueli, Toso, Christian, Van Delden, Christian, Venetz, Jean-Pierre, Villard, Jean, Vionnet, Julien, Wick, Madeleine, Wilhlem, Markus, Yerly, Patrick, Dirchwolf, Melisa, Becchetti, Chiara, Gschwend, Sarah G., Dutkowski, Philipp, Beyeler, Franziska, Schropp, Jonas, and Dufour, Jean-François

Published
2022
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15. Broadly neutralizing antibodies overcome SARS-CoV-2 Omicron antigenic shift

Author

Cameroni, Elisabetta, Bowen, John E., Rosen, Laura E., Saliba, Christian, Zepeda, Samantha K., Culap, Katja, Pinto, Dora, VanBlargan, Laura A., De Marco, Anna, di Iulio, Julia, Zatta, Fabrizia, Kaiser, Hannah, Noack, Julia, Farhat, Nisar, Czudnochowski, Nadine, Havenar-Daughton, Colin, Sprouse, Kaitlin R., Dillen, Josh R., Powell, Abigail E., Chen, Alex, Maher, Cyrus, Yin, Li, Sun, David, Soriaga, Leah, Bassi, Jessica, Silacci-Fregni, Chiara, Gustafsson, Claes, Franko, Nicholas M., Logue, Jenni, Iqbal, Najeeha Talat, Mazzitelli, Ignacio, Geffner, Jorge, Grifantini, Renata, Chu, Helen, Gori, Andrea, Riva, Agostino, Giannini, Olivier, Ceschi, Alessandro, Ferrari, Paolo, Cippà, Pietro E., Franzetti-Pellanda, Alessandra, Garzoni, Christian, Halfmann, Peter J., Kawaoka, Yoshihiro, Hebner, Christy, Purcell, Lisa A., Piccoli, Luca, Pizzuto, Matteo Samuele, Walls, Alexandra C., Diamond, Michael S., Telenti, Amalio, Virgin, Herbert W., Lanzavecchia, Antonio, Snell, Gyorgy, Veesler, David, and Corti, Davide

Published
2022
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19. Immunogenicity of High-Dose Versus MF59-Adjuvanted Versus Standard Influenza Vaccine in Solid Organ Transplant Recipients: The Swiss/Spanish Trial in Solid Organ Transplantation on Prevention of Influenza (STOP-FLU Trial)

Author

Swiss National Science Foundation, Sánchez-Céspedes, Javier [0000-0003-2707-1979], Mombelli, Matteo, Neofytos, Dionysios, Huynh-Do, Uyen, Sánchez-Céspedes, Javier, Stampf, Susanne, Golshayan, Dela, Dahdal, Suzan, Stirnimann, Guido, Schnyder, Aurelia, Garzoni, Christian, Venzin, Reto M., Magenta, Lorenzo, Schönenberger, Melanie, Walti, Laura, Hirzel, Cédric, Munting, Aline, Dickenmann, Michael, Koller, Michael, Aubert, John-David, Steiger, Jürg, Pascual, Manuel, Mueller, Thomas F., Schuurmans, Macé, Berger, Christoph, Binet, Isabelle, Villard, Jean, Mueller, Nicolas J., Egli, Adrian, Cordero, Van Delden, Christian, Manuel, Oriol, Swiss National Science Foundation, Sánchez-Céspedes, Javier [0000-0003-2707-1979], Mombelli, Matteo, Neofytos, Dionysios, Huynh-Do, Uyen, Sánchez-Céspedes, Javier, Stampf, Susanne, Golshayan, Dela, Dahdal, Suzan, Stirnimann, Guido, Schnyder, Aurelia, Garzoni, Christian, Venzin, Reto M., Magenta, Lorenzo, Schönenberger, Melanie, Walti, Laura, Hirzel, Cédric, Munting, Aline, Dickenmann, Michael, Koller, Michael, Aubert, John-David, Steiger, Jürg, Pascual, Manuel, Mueller, Thomas F., Schuurmans, Macé, Berger, Christoph, Binet, Isabelle, Villard, Jean, Mueller, Nicolas J., Egli, Adrian, Cordero, Van Delden, Christian, and Manuel, Oriol

Abstract

[Background] The immunogenicity of the standard influenza vaccine is reduced in solid-organ transplant (SOT) recipients, so new vaccination strategies are needed in this population., [Methods] Adult SOT recipients from 9 transplant clinics in Switzerland and Spain were enrolled if they were >3 months after transplantation. Patients were randomized (1:1:1) to a MF59-adjuvanted or a high-dose vaccine (intervention), or a standard vaccine (control), with stratification by organ and time from transplant. The primary outcome was vaccine response rate, defined as a ≥4-fold increase of hemagglutination-inhibition titers to at least 1 vaccine strain at 28 days postvaccination. Secondary outcomes included polymerase chain reaction–confirmed influenza and vaccine reactogenicity., [Results] A total of 619 patients were randomized, 616 received the assigned vaccines, and 598 had serum available for analysis of the primary endpoint (standard, n = 198; MF59-adjuvanted, n = 205; high-dose, n = 195 patients). Vaccine response rates were 42% (84/198) in the standard vaccine group, 60% (122/205) in the MF59-adjuvanted vaccine group, and 66% (129/195) in the high-dose vaccine group (difference in intervention vaccines vs standard vaccine, 0.20; 97.5% confidence interval [CI], .12–1); P < .001; difference in high-dose vs standard vaccine, 0.24 [95% CI, .16–1]; P < .001; difference in MF59-adjuvanted vs standard vaccine, 0.17 [97.5% CI, .08–1]; P < .001). Influenza occurred in 6% of the standard, 5% in the MF59-adjuvanted, and 7% in the high-dose vaccine groups. Vaccine-related adverse events occurred more frequently in the intervention vaccine groups, but most of the events were mild., [Conclusions] In SOT recipients, use of an MF59-adjuvanted or a high-dose influenza vaccine was safe and resulted in a higher vaccine response rate.

Published
2024

20. Do Infectious Diseases After Kidney Retransplantation Differ From Those After First Kidney Transplantation?

Author

Kusejko, Katharina; https://orcid.org/0000-0002-4638-1940, Neofytos, Dionysios; https://orcid.org/0000-0001-6970-2869, van Delden, Christian; https://orcid.org/0000-0002-2901-8285, Hirsch, Hans H; https://orcid.org/0000-0003-0883-0423, Meylan, Pascal, Boggian, Katia, Hirzel, Cédric; https://orcid.org/0000-0002-7870-912X, Garzoni, Christian; https://orcid.org/0000-0002-0832-2376, Sidler, Daniel; https://orcid.org/0000-0002-2435-5936, Schnyder, Aurelia, Schaub, Stefan; https://orcid.org/0000-0002-9170-1341, Golshayan, Déla, Haidar, Fadi, Bonani, Marco, Kouyos, Roger D; https://orcid.org/0000-0002-9220-8348, Mueller, Nicolas J; https://orcid.org/0000-0002-1059-3191, Schreiber, Peter W; https://orcid.org/0000-0001-8123-2601, Swiss Transplant Cohort Study, et al, Kusejko, Katharina; https://orcid.org/0000-0002-4638-1940, Neofytos, Dionysios; https://orcid.org/0000-0001-6970-2869, van Delden, Christian; https://orcid.org/0000-0002-2901-8285, Hirsch, Hans H; https://orcid.org/0000-0003-0883-0423, Meylan, Pascal, Boggian, Katia, Hirzel, Cédric; https://orcid.org/0000-0002-7870-912X, Garzoni, Christian; https://orcid.org/0000-0002-0832-2376, Sidler, Daniel; https://orcid.org/0000-0002-2435-5936, Schnyder, Aurelia, Schaub, Stefan; https://orcid.org/0000-0002-9170-1341, Golshayan, Déla, Haidar, Fadi, Bonani, Marco, Kouyos, Roger D; https://orcid.org/0000-0002-9220-8348, Mueller, Nicolas J; https://orcid.org/0000-0002-1059-3191, Schreiber, Peter W; https://orcid.org/0000-0001-8123-2601, Swiss Transplant Cohort Study, and et al

Abstract

Background Infectious diseases (IDs) are highly relevant after solid organ transplantation in terms of morbidity and mortality, being among the most common causes of death. Patients undergoing kidney retransplantation (re-K-Tx) have been already receiving immunosuppressive therapy over a prolonged period, potentially facilitating subsequent infections. Comparing ID events after re-K-Tx and first kidney transplantation (f-K-Tx) can delineate patterns and risks of ID events associated with prolonged immunosuppression. Methods We included adult patients with records on f-K-Tx and re-K-Tx in the Swiss Transplant Cohort Study. We analyzed ID events after f-K-Tx and re-K-Tx within the same patients and compared infection rates, causative pathogens, and infection sites. Recurrent time-to-event analyses were performed for comparison of infection rates. Results A total of 59 patients with a median age of 47 years (range, 18–73) were included. Overall, 312 ID events in 52 patients occurred. In multivariable recurrent event modeling, the rate of ID events was significantly lower after re-K-Tx (hazard ratio, 0.70; P = .02). More bacterial (68.9% vs 60.4%) and fungal (4.0% vs 1.1%) infections were observed after f-K-Tx but fewer viral infections (27.0% vs 38.5%) as compared with re-K-Tx (P = .11). After f-K-Tx, urinary and gastrointestinal tract infections were more frequent; after re-K-Tx, respiratory tract and surgical site infections were more frequent (P < .001). Conclusions ID events were less frequent after re-K-Tx. Affected sites differed significantly after f-K-Tx vs re-K-Tx.

Published
2024

21. Patient leaflets on respiratory tract infections did not improve shared decision making and antibiotic prescriptions in a low-prescriber setting

Author

Plate, Andreas; https://orcid.org/0000-0001-6143-5479, Di Gangi, Stefania; https://orcid.org/0000-0002-2847-6399, Garzoni, Christian; https://orcid.org/0000-0002-0832-2376, Selby, Kevin, Pichierri, Giuseppe; https://orcid.org/0000-0002-3582-5219, Senn, Oliver; https://orcid.org/0000-0003-4422-7250, Neuner-Jehle, Stefan; https://orcid.org/0000-0002-6260-8148, Plate, Andreas; https://orcid.org/0000-0001-6143-5479, Di Gangi, Stefania; https://orcid.org/0000-0002-2847-6399, Garzoni, Christian; https://orcid.org/0000-0002-0832-2376, Selby, Kevin, Pichierri, Giuseppe; https://orcid.org/0000-0002-3582-5219, Senn, Oliver; https://orcid.org/0000-0003-4422-7250, and Neuner-Jehle, Stefan; https://orcid.org/0000-0002-6260-8148

Abstract

Patient information leaflets can reduce antibiotic prescription rates by improving knowledge and encouraging shared decision making (SDM) in patients with respiratory tract infections (RTI). The effect of these interventions in antibiotic low-prescriber settings is unknown. We conducted a pragmatic pre-/post interventional study between October 2022 and March 2023 in Swiss outpatient care. The intervention was the provision of patient leaflets informing about RTIs and antibiotics use. Main outcomes were the extent of SDM, antibiotic prescription rates, and patients' awareness/knowledge about antibiotic use in RTIs. 408 patients participated in the pre-intervention period, and 315 patients in the post- intervention period. There was no difference in the extent of SDM (mean score (range 0-100): 65.86 vs. 64.65, p = 0.565), nor in antibiotic prescription rates (no prescription: 89.8% vs. 87.2%, p = 0.465) between the periods. Overall awareness/knowledge among patients with RTI was high and leaflets showed only a small effect on overall awareness/knowledge. In conclusion, in an antibiotic low-prescriber setting, patient information leaflets may improve knowledge, but may not affect treatment decisions nor antibiotic prescription rates for RTIs.

Published
2024

22. Immunogenicity of High-Dose vs. MF59-adjuvanted vs. Standard Influenza Vaccine in Solid Organ Transplant Recipients: The STOP-FLU trial

Author

Mombelli, Matteo, Neofytos, Dionysios; https://orcid.org/0000-0001-6970-2869, Huynh-Do, Uyen, Sánchez-Céspedes, Javier, Stampf, Susanne, Golshayan, Dela, Dahdal, Suzan, Stirnimann, Guido, Schnyder, Aurelia, Garzoni, Christian, Venzin, Reto M, Magenta, Lorenzo, Schönenberger, Melanie, Walti, Laura, Hirzel, Cédric, Munting, Aline, Dickenmann, Michael, Koller, Michael, Aubert, John-David, Steiger, Jürg, Pascual, Manuel, Mueller, Thomas F, Schuurmans, Macé, Berger, Christoph, Binet, Isabelle, Villard, Jean, Mueller, Nicolas J, Egli, Adrian; https://orcid.org/0000-0002-3564-8603, Cordero, Elisa, van Delden, Christian, et al, Mombelli, Matteo, Neofytos, Dionysios; https://orcid.org/0000-0001-6970-2869, Huynh-Do, Uyen, Sánchez-Céspedes, Javier, Stampf, Susanne, Golshayan, Dela, Dahdal, Suzan, Stirnimann, Guido, Schnyder, Aurelia, Garzoni, Christian, Venzin, Reto M, Magenta, Lorenzo, Schönenberger, Melanie, Walti, Laura, Hirzel, Cédric, Munting, Aline, Dickenmann, Michael, Koller, Michael, Aubert, John-David, Steiger, Jürg, Pascual, Manuel, Mueller, Thomas F, Schuurmans, Macé, Berger, Christoph, Binet, Isabelle, Villard, Jean, Mueller, Nicolas J, Egli, Adrian; https://orcid.org/0000-0002-3564-8603, Cordero, Elisa, van Delden, Christian, and et al

Abstract

BACKGROUND The immunogenicity of the standard influenza vaccine is reduced in solid-organ transplant (SOT) recipients, so that new vaccination strategies are needed in this population. METHODS Adult SOT recipients from nine transplant clinics in Switzerland and Spain were enrolled if they were >3 months after transplantation. High, with stratification by organ and time from transplant. The primary outcome was vaccine response rate, defined as a ≥4-fold increase of hemagglutination-inhibition titers to at least one vaccine strain at 28 days post-vaccination. Secondary outcomes included PCR-confirmed influenza and vaccine reactogenicity. RESULTS 619 patients were randomized, 616 received the assigned vaccines, and 598 had serum available for analysis of the primary endpoint (standard, n=198; MF59-adjuvanted, n=205; high-dose, n=195 patients). Vaccine response rates were 42% (84/198) in the standard vaccine group, 60% (122/205) in the MF59-adjuvanted vaccine group, and 66% (129/195) in the high-dose vaccine group (difference in intervention vaccines vs. standard vaccine, 0.20 [97.5% CI 0.12-1]; p<0.001; difference in high-dose vs. standard vaccine, 0.24 [95% CI 0.16-1]; p<0.001; difference in MF59-adjuvanted vs. standard vaccine, 0.17 [97.5% CI 0.08-1]; p<0.001). Influenza occurred in 6% the standard, 5% in the MF59-adjuvanted, and 7% in the high-dose vaccine groups. Vaccine-related adverse events occurred more frequently in the intervention vaccine groups, but most of the events were mild. CONCLUSIONS In SOT recipients, use of an MF59-adjuvanted or a high-dose influenza vaccine was safe and resulted in a higher vaccine response rate. TRIAL REGISTRATION Clinicaltrials.gov NCT03699839.

Published
2024

23. Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies

Author

Collier, Dami A., De Marco, Anna, Ferreira, Isabella A. T. M., Meng, Bo, Datir, Rawlings P., Walls, Alexandra C., Kemp, Steven A., Bassi, Jessica, Pinto, Dora, Silacci-Fregni, Chiara, Bianchi, Siro, Tortorici, M. Alejandra, Bowen, John, Culap, Katja, Jaconi, Stefano, Cameroni, Elisabetta, Snell, Gyorgy, Pizzuto, Matteo S., Pellanda, Alessandra Franzetti, Garzoni, Christian, Riva, Agostino, Elmer, Anne, Kingston, Nathalie, Graves, Barbara, McCoy, Laura E., Smith, Kenneth G. C., Bradley, John R., Temperton, Nigel, Ceron-Gutierrez, Lourdes, Barcenas-Morales, Gabriela, Harvey, William, Virgin, Herbert W., Lanzavecchia, Antonio, Piccoli, Luca, Doffinger, Rainer, Wills, Mark, Veesler, David, Corti, Davide, and Gupta, Ravindra K.

Published
2021
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25. Author Correction: Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies

Author

Collier, Dami A., De Marco, Anna, Ferreira, Isabella A. T. M., Meng, Bo, Datir, Rawlings P., Walls, Alexandra C., Kemp, Steven A., Bassi, Jessica, Pinto, Dora, Silacci-Fregni, Chiara, Bianchi, Siro, Tortorici, M. Alejandra, Bowen, John, Culap, Katja, Jaconi, Stefano, Cameroni, Elisabetta, Snell, Gyorgy, Pizzuto, Matteo S., Pellanda, Alessandra Franzetti, Garzoni, Christian, Riva, Agostino, Elmer, Anne, Kingston, Nathalie, Graves, Barbara, McCoy, Laura E., Smith, Kenneth G. C., Bradley, John R., Temperton, Nigel, Ceron-Gutierrez, Lourdes, Barcenas-Morales, Gabriela, Harvey, William, Virgin, Herbert W., Lanzavecchia, Antonio, Piccoli, Luca, Doffinger, Rainer, Wills, Mark, Veesler, David, Corti, Davide, and Gupta, Ravindra K.

Published
2022
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29. Do Infectious Diseases After Kidney Retransplantation Differ From Those After First Kidney Transplantation?

Author

Kusejko, Katharina, Neofytos, Dionysios, Delden, Christian van, Hirsch, Hans H, Meylan, Pascal, Boggian, Katia, Hirzel, Cedric, Garzoni, Christian, Sidler, Daniel, Schnyder, Aurelia, Schaub, Stefan, Golshayan, Déla, Haidar, Fadi, Bonani, Marco, Kouyos, Roger D, Mueller, Nicolas J, Schreiber, Peter W, and Study, the Swiss Transplant Cohort

Abstract

Background Infectious diseases (IDs) are highly relevant after solid organ transplantation in terms of morbidity and mortality, being among the most common causes of death. Patients undergoing kidney retransplantation (re-K-Tx) have been already receiving immunosuppressive therapy over a prolonged period, potentially facilitating subsequent infections. Comparing ID events after re-K-Tx and first kidney transplantation (f-K-Tx) can delineate patterns and risks of ID events associated with prolonged immunosuppression. Methods We included adult patients with records on f-K-Tx and re-K-Tx in the Swiss Transplant Cohort Study. We analyzed ID events after f-K-Tx and re-K-Tx within the same patients and compared infection rates, causative pathogens, and infection sites. Recurrent time-to-event analyses were performed for comparison of infection rates. Results A total of 59 patients with a median age of 47 years (range, 18–73) were included. Overall, 312 ID events in 52 patients occurred. In multivariable recurrent event modeling, the rate of ID events was significantly lower after re-K-Tx (hazard ratio, 0.70; P =.02). More bacterial (68.9% vs 60.4%) and fungal (4.0% vs 1.1%) infections were observed after f-K-Tx but fewer viral infections (27.0% vs 38.5%) as compared with re-K-Tx (P =.11). After f-K-Tx, urinary and gastrointestinal tract infections were more frequent; after re-K-Tx, respiratory tract and surgical site infections were more frequent (P <.001). Conclusions ID events were less frequent after re-K-Tx. Affected sites differed significantly after f-K-Tx vs re-K-Tx. [ABSTRACT FROM AUTHOR]

Published
2024
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30. Immunogenicity of High-Dose Versus MF59-Adjuvanted Versus Standard Influenza Vaccine in Solid Organ Transplant Recipients: The Swiss/Spanish Trial in Solid Organ Transplantation on Prevention of Influenza (STOP-FLU Trial).

Author

Mombelli, Matteo, Neofytos, Dionysios, Huynh-Do, Uyen, Sánchez-Céspedes, Javier, Stampf, Susanne, Golshayan, Dela, Dahdal, Suzan, Stirnimann, Guido, Schnyder, Aurelia, Garzoni, Christian, Venzin, Reto M, Magenta, Lorenzo, Schönenberger, Melanie, Walti, Laura, Hirzel, Cédric, Munting, Aline, Dickenmann, Michael, Koller, Michael, Aubert, John-David, and Steiger, Jürg

Subjects
INFLUENZA prevention, INFLUENZA vaccines, HEMAGGLUTINATION tests, CONFIDENCE intervals, VACCINE immunogenicity, PATIENTS, VACCINE effectiveness, RANDOMIZED controlled trials, COMPARATIVE studies, DESCRIPTIVE statistics, RESEARCH funding, POLYMERASE chain reaction, STATISTICAL sampling, TRANSPLANTATION of organs, tissues, etc., EVALUATION
Abstract

Background The immunogenicity of the standard influenza vaccine is reduced in solid-organ transplant (SOT) recipients, so new vaccination strategies are needed in this population. Methods Adult SOT recipients from 9 transplant clinics in Switzerland and Spain were enrolled if they were >3 months after transplantation. Patients were randomized (1:1:1) to a MF59-adjuvanted or a high-dose vaccine (intervention), or a standard vaccine (control), with stratification by organ and time from transplant. The primary outcome was vaccine response rate, defined as a ≥4-fold increase of hemagglutination-inhibition titers to at least 1 vaccine strain at 28 days postvaccination. Secondary outcomes included polymerase chain reaction–confirmed influenza and vaccine reactogenicity. Results A total of 619 patients were randomized, 616 received the assigned vaccines, and 598 had serum available for analysis of the primary endpoint (standard, n = 198; MF59-adjuvanted, n = 205; high-dose, n = 195 patients). Vaccine response rates were 42% (84/198) in the standard vaccine group, 60% (122/205) in the MF59-adjuvanted vaccine group, and 66% (129/195) in the high-dose vaccine group (difference in intervention vaccines vs standard vaccine, 0.20; 97.5% confidence interval [CI],.12–1); P <.001; difference in high-dose vs standard vaccine, 0.24 [95% CI,.16–1]; P <.001; difference in MF59-adjuvanted vs standard vaccine, 0.17 [97.5% CI,.08–1]; P <.001). Influenza occurred in 6% of the standard, 5% in the MF59-adjuvanted, and 7% in the high-dose vaccine groups. Vaccine-related adverse events occurred more frequently in the intervention vaccine groups, but most of the events were mild. Conclusions In SOT recipients, use of an MF59-adjuvanted or a high-dose influenza vaccine was safe and resulted in a higher vaccine response rate. Clinical Trials Registration Clinicaltrials.gov NCT03699839. [ABSTRACT FROM AUTHOR]

Published
2024
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31. Maturation of SARS-CoV-2 Spike-specific memory B cells drives resilience to viral escape

Author

Marzi, Roberta; https://orcid.org/0000-0001-6025-6735, Bassi, Jessica; https://orcid.org/0000-0002-4723-6892, Silacci-Fregni, Chiara, Bartha, Istvan; https://orcid.org/0000-0003-3360-1999, Muoio, Francesco; https://orcid.org/0000-0003-4963-8665, Culap, Katja; https://orcid.org/0000-0002-0956-0018, Sprugasci, Nicole; https://orcid.org/0000-0003-3258-5552, Lombardo, Gloria, Saliba, Christian; https://orcid.org/0000-0003-0100-6976, Cameroni, Elisabetta, Cassotta, Antonino; https://orcid.org/0000-0001-8674-4294, Low, Jun Siong; https://orcid.org/0000-0002-1775-0778, Walls, Alexandra C; https://orcid.org/0000-0002-9636-8330, McCallum, Matthew; https://orcid.org/0000-0001-8398-8330, Tortorici, M Alejandra; https://orcid.org/0000-0002-2260-2577, Bowen, John E; https://orcid.org/0000-0003-3590-9727, Dellota, Exequiel A, Dillen, Josh R, Czudnochowski, Nadine; https://orcid.org/0000-0002-3146-4110, Pertusini, Laura, Terrot, Tatiana, Lepori, Valentino, Tarkowski, Maciej, Riva, Agostino, Biggiogero, Maira, Franzetti-Pellanda, Alessandra, Garzoni, Christian, Ferrari, Paolo; https://orcid.org/0000-0002-9619-3104, Ceschi, Alessandro; https://orcid.org/0000-0002-4308-0405, Giannini, Olivier, et al, Marzi, Roberta; https://orcid.org/0000-0001-6025-6735, Bassi, Jessica; https://orcid.org/0000-0002-4723-6892, Silacci-Fregni, Chiara, Bartha, Istvan; https://orcid.org/0000-0003-3360-1999, Muoio, Francesco; https://orcid.org/0000-0003-4963-8665, Culap, Katja; https://orcid.org/0000-0002-0956-0018, Sprugasci, Nicole; https://orcid.org/0000-0003-3258-5552, Lombardo, Gloria, Saliba, Christian; https://orcid.org/0000-0003-0100-6976, Cameroni, Elisabetta, Cassotta, Antonino; https://orcid.org/0000-0001-8674-4294, Low, Jun Siong; https://orcid.org/0000-0002-1775-0778, Walls, Alexandra C; https://orcid.org/0000-0002-9636-8330, McCallum, Matthew; https://orcid.org/0000-0001-8398-8330, Tortorici, M Alejandra; https://orcid.org/0000-0002-2260-2577, Bowen, John E; https://orcid.org/0000-0003-3590-9727, Dellota, Exequiel A, Dillen, Josh R, Czudnochowski, Nadine; https://orcid.org/0000-0002-3146-4110, Pertusini, Laura, Terrot, Tatiana, Lepori, Valentino, Tarkowski, Maciej, Riva, Agostino, Biggiogero, Maira, Franzetti-Pellanda, Alessandra, Garzoni, Christian, Ferrari, Paolo; https://orcid.org/0000-0002-9619-3104, Ceschi, Alessandro; https://orcid.org/0000-0002-4308-0405, Giannini, Olivier, and et al

Published
2023

32. Vaccine-Preventable Infections Among Solid Organ Transplant Recipients in Switzerland

Author

Walti, Laura N, Mugglin, Catrina, Mombelli, Matteo, Manuel, Oriol, Hirsch, Hans H, Khanna, Nina, Mueller, Nicolas J, Berger, Christoph, Boggian, Katia, Garzoni, Christian, Neofytos, Dionysios, van Delden, Christian, Mäusezahl, Mirjam, Hirzel, Cédric, Swiss Transplant Cohort Study, Walti, Laura N, Mugglin, Catrina, Mombelli, Matteo, Manuel, Oriol, Hirsch, Hans H, Khanna, Nina, Mueller, Nicolas J, Berger, Christoph, Boggian, Katia, Garzoni, Christian, Neofytos, Dionysios, van Delden, Christian, Mäusezahl, Mirjam, Hirzel, Cédric, and Swiss Transplant Cohort Study

Abstract

IMPORTANCE Vaccine responses are decreased in solid organ transplant (SOT) recipients, and given the complexity of implementation, vaccination programs may be suboptimal. The actual burden of vaccine-preventable infections (VPIs) among SOT recipients remains unclear. OBJECTIVES To assess the incidence rate of VPIs among SOT recipients and to evaluate whether SOT recipients are at increased risk for specific VPIs compared with the general population. DESIGN, SETTING, AND PARTICIPANTS This nationwide cohort study used data from the Swiss Transplant Cohort Study on VPIs in individuals who underwent SOT from May 2008 to June 2019 (follow-up until December 2019) and data from the Swiss Federal Office of Public Health on notifiable VPIs in the general population in the same period. Data were analyzed from January 2021 to June 2022. EXPOSURES Solid organ transplant. MAIN OUTCOMES AND MEASURES The main outcomes were the incidence rate of the following VPIs in SOT recipients: hepatitis A and B, diphtheria, Haemophilus influenzae infection, influenza, measles, mumps, pertussis, pneumococcal disease, poliomyelitis, meningococcal disease, rubella, tetanus, tick-borne encephalitis, and varicella zoster virus infection. Age-adjusted standardized incidence ratios were used to assess whether VPIs occurred more frequently in SOT recipients compared with the general population. For SOT recipients, factors associated with occurrence of VPIs were explored and the associated morbidity and mortality assessed. RESULTS Of 4967 SOT recipients enrolled (median age, 54 years [IQR, 42-62 years]; 3191 [64.2%] male), 593 (11.9%) experienced at least 1 VPI. The overall VPI incidence rate was higher in the population that underwent SOT (30.57 per 1000 person-years [PY]; 95% CI, 28.24-33.10 per 1000 PY) compared with the general population (0.71 per 1000 PY). The standardized age-adjusted incidence ratio for notifiable VPIs in SOT recipients was higher compared with the general population (27.84; 9

Published
2023

33. Bloodstream infections in allogeneic haematopoietic cell recipients from the Swiss Transplant Cohort Study: trends of causative pathogens and resistance rates

Author

Sava, Mihaela; https://orcid.org/0000-0001-5763-9073, Bättig, Veronika; https://orcid.org/0000-0002-7418-977X, Gerull, Sabine; https://orcid.org/0000-0002-6612-4220, Passweg, Jakob R; https://orcid.org/0000-0001-7092-3351, Khanna, Nina; https://orcid.org/0000-0002-2642-419X, Garzoni, Christian; https://orcid.org/0000-0002-0832-2376, Gerber, Bernhard; https://orcid.org/0000-0003-1708-8558, Mueller, Nicolas J; https://orcid.org/0000-0002-1059-3191, Schanz, Urs, Berger, Christoph; https://orcid.org/0000-0002-1730-8824, Chalandon, Yves; https://orcid.org/0000-0001-9341-8104, van Delden, Christian; https://orcid.org/0000-0002-2901-8285, Neofytos, Dionysios; https://orcid.org/0000-0001-6970-2869, Stampf, Susanne; https://orcid.org/0000-0003-3399-5078, Franzeck, Fabian C; https://orcid.org/0000-0001-7510-0231, Weisser, Maja; https://orcid.org/0000-0002-0134-1929, Sava, Mihaela; https://orcid.org/0000-0001-5763-9073, Bättig, Veronika; https://orcid.org/0000-0002-7418-977X, Gerull, Sabine; https://orcid.org/0000-0002-6612-4220, Passweg, Jakob R; https://orcid.org/0000-0001-7092-3351, Khanna, Nina; https://orcid.org/0000-0002-2642-419X, Garzoni, Christian; https://orcid.org/0000-0002-0832-2376, Gerber, Bernhard; https://orcid.org/0000-0003-1708-8558, Mueller, Nicolas J; https://orcid.org/0000-0002-1059-3191, Schanz, Urs, Berger, Christoph; https://orcid.org/0000-0002-1730-8824, Chalandon, Yves; https://orcid.org/0000-0001-9341-8104, van Delden, Christian; https://orcid.org/0000-0002-2901-8285, Neofytos, Dionysios; https://orcid.org/0000-0001-6970-2869, Stampf, Susanne; https://orcid.org/0000-0003-3399-5078, Franzeck, Fabian C; https://orcid.org/0000-0001-7510-0231, and Weisser, Maja; https://orcid.org/0000-0002-0134-1929

Published
2023

34. Human neutralizing antibodies to cold linear epitopes and subdomain 1 of the SARS-CoV-2 spike glycoprotein

Author

Bianchini, Filippo, primary, Crivelli, Virginia, additional, Abernathy, Morgan E., additional, Guerra, Concetta, additional, Palus, Martin, additional, Muri, Jonathan, additional, Marcotte, Harold, additional, Piralla, Antonio, additional, Pedotti, Mattia, additional, De Gasparo, Raoul, additional, Simonelli, Luca, additional, Matkovic, Milos, additional, Toscano, Chiara, additional, Biggiogero, Maira, additional, Calvaruso, Veronica, additional, Svoboda, Pavel, additional, Cervantes Rincón, Tomás, additional, Fava, Tommaso, additional, Podešvová, Lucie, additional, Shanbhag, Akanksha A., additional, Celoria, Andrea, additional, Sgrignani, Jacopo, additional, Stefanik, Michal, additional, Hönig, Vaclav, additional, Pranclova, Veronika, additional, Michalcikova, Tereza, additional, Prochazka, Jan, additional, Guerrini, Giuditta, additional, Mehn, Dora, additional, Ciabattini, Annalisa, additional, Abolhassani, Hassan, additional, Jarrossay, David, additional, Uguccioni, Mariagrazia, additional, Medaglini, Donata, additional, Pan-Hammarström, Qiang, additional, Calzolai, Luigi, additional, Fernandez, Daniel, additional, Baldanti, Fausto, additional, Franzetti-Pellanda, Alessandra, additional, Garzoni, Christian, additional, Sedlacek, Radislav, additional, Ruzek, Daniel, additional, Varani, Luca, additional, Cavalli, Andrea, additional, Barnes, Christopher O., additional, and Robbiani, Davide F., additional

Published
2023
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35. Therapeutic and vaccine-induced cross-reactive antibodies with effector function against emerging Omicron variants

Author

Addetia, Amin, primary, Piccoli, Luca, additional, Case, James Brett, additional, Park, Young-Jun, additional, Beltramello, Martina, additional, Guarino, Barbara, additional, Dang, Ha, additional, Pinto, Dora, additional, Scheaffer, Suzanne M., additional, Sprouse, Kaitlin, additional, Bassi, Jessica, additional, Silacci-Fregni, Chiara, additional, Muoio, Francesco, additional, Dini, Marco, additional, Vincenzetti, Lucia, additional, Acosta, Rima, additional, Johnson, Daisy, additional, Subramanian, Sambhavi, additional, Saliba, Christian, additional, Giurdanella, Martina, additional, Lombardo, Gloria, additional, Leoni, Giada, additional, Culap, Katja, additional, McAlister, Carley, additional, Rajesh, Anushka, additional, Dellota, Exequiel, additional, Zhou, Jiayi, additional, Farhat, Nisar, additional, Bohan, Dana, additional, Noack, Julia, additional, Lempp, Florian A., additional, Cameroni, Elisabetta, additional, Whitener, Bradley, additional, Giannini, Olivier, additional, Ceschi, Alessandro, additional, Ferrari, Paolo, additional, Franzetti-Pellanda, Alessandra, additional, Biggiogero, Maira, additional, Garzoni, Christian, additional, Zappi, Stephanie, additional, Bernasconi, Luca, additional, Kim, Min Jeong, additional, Schnell, Gretja, additional, Czudnochowski, Nadine, additional, Franko, Nicholas, additional, Logue, Jennifer K., additional, Yoshiyama, Courtney, additional, Stewart, Cameron, additional, Chu, Helen, additional, Schmid, Michael A., additional, Purcell, Lisa A., additional, Snell, Gyorgy, additional, Lanzavecchia, Antonio, additional, Diamond, Michael S., additional, Corti, Davide, additional, and Veesler, David, additional

Published
2023
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36. Immunogenicity, Efficacy, and Safety of High-Dose Trivalent vs. MF59-Adjuvanted Trivalent vs. Standard-Dose Non-Adjuvanted Quadrivalent Influenza Vaccine in Solid Organ Transplant Recipients: A Randomised Clinical Trial.&nbsp;The STOP-FLU Trial

Author

Mombelli, Matteo, primary, Neofytos, Dionysios, additional, Huynh-Do, Uyen, additional, Sánchez-Céspedes, Javier, additional, Stampf, Susanne, additional, Golshayan, Dela, additional, Dahdal, Suzan, additional, Stirnimann, Guido, additional, Schnyder, Aurelia, additional, Garzoni, Christian, additional, Venzin, Reto M., additional, Magenta, Lorenzo, additional, Schönenberger, Melanie, additional, Walti, Laura N., additional, Hirzel, Cédric, additional, Munting, Aline, additional, Dickenmann, Michael, additional, Koller, Michael, additional, Aubert, John-David, additional, Steiger, Jurg, additional, Pascual, Manuel, additional, Müller, Thomas F., additional, Schuurmans, Macé M., additional, Berger, Christoph, additional, Binet, Isabelle, additional, Villard, Jean, additional, Mueller, Nicolas J., additional, Egli, Adrian, additional, Cordero, Elisa, additional, van Delden, Christian, additional, Manuel, Oriol Josep, additional, and Study, Swiss Transplant Cohort, additional

Published
2023
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37. Reply to Cunha et al

Author

Swiss Transplant Cohort Study, Wójtowicz, Agnieszka, Lecompte, Thanh Doco, Bibert, Stéphanie, Manuel, Oriol, Rüeger, Sina, Berger, Christoph, Boggian, Katia, Cusini, Alexia, Garzoni, Christian, Khanna, Nina, Mueller, Nicolas J., Meylan, Pascal R., Pascual, Manuel, van Delden, Christian, and Bochud, Pierre-Yves

Published
2015
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39. IL1B and DEFB1 Polymorphisms Increase Susceptibility to Invasive Mold Infection After Solid-Organ Transplantation

Author

Wójtowicz, Agnieszka, Gresnigt, Mark S., Lecompte, Thanh, Bibert, Stephanie, Manuel, Oriol, Joosten, Leo A.B., Rüeger, Sina, Berger, Christoph, Boggian, Katia, Cusini, Alexia, Garzoni, Christian, Hirsch, Hans H., Weisser, Maja, Mueller, Nicolas J., Meylan, Pascal R., Steiger, Jürg, Kutalik, Zoltan, Pascual, Manuel, van Delden, Christian, van de Veerdonk, Frank L, and Bochud, Pierre-Yves

Published
2015

41. Pulmonary Recovery 12 Months after Non-Severe and Severe COVID-19: The Prospective Swiss COVID-19 Lung Study

Author

Lenoir, Alexandra, primary, Christe, Andreas, additional, Ebner, Lukas, additional, Beigelman-Aubry, Catherine, additional, Bridevaux, Pierre-Olivier, additional, Brutsche, Martin, additional, Clarenbach, Christian, additional, Erkosar, Berra, additional, Garzoni, Christian, additional, Geiser, Thomas, additional, Guler, Sabina A., additional, Heg, Dik, additional, Lador, Frédéric, additional, Mancinetti, Marco, additional, Ott, Sebastian R., additional, Piquilloud, Lise, additional, Prella, Maura, additional, Que, Yok-Ai, additional, von Garnier, Christophe, additional, and Funke-Chambour, Manuela, additional

Published
2022
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42. Epidemiology and outcomes of bone and joint infections in solid organ transplant recipients

Author

Pham, Truong-Thanh, primary, Andrey, Diego O., additional, Stampf, Susanne, additional, Burkhard, Sara H., additional, Hirzel, Cédric, additional, Tschopp, Johnathan, additional, Ullrich, Kathrin, additional, Strahm, Carol, additional, Schreiber, Peter W., additional, Boillat-Blanco, Noémie, additional, Garzoni, Christian, additional, Khanna, Nina, additional, Manuel, Oriol, additional, Mueller, Nicolas J., additional, Suva, Domizio, additional, van Delden, Christian, additional, Uçkay, Ilker, additional, and Neofytos, Dionysios, additional

Published
2022
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43. Human neutralizing antibodies to cold linear epitopes and to subdomain 1 of SARS-CoV-2

Author

Bianchini, Filippo, primary, Crivelli, Virginia, additional, Abernathy, Morgan E., additional, Guerra, Concetta, additional, Palus, Martin, additional, Muri, Jonathan, additional, Marcotte, Harold, additional, Piralla, Antonio, additional, Pedotti, Mattia, additional, Gasparo, Raoul De, additional, Simonelli, Luca, additional, Matkovic, Milos, additional, Toscano, Chiara, additional, Biggiogero, Maira, additional, Calvaruso, Veronica, additional, Svoboda, Pavel, additional, Rincón, Tomás Cervantes, additional, Fava, Tommaso, additional, Podešvová, Lucie, additional, Shanbhag, Akanksha A., additional, Celoria, Andrea, additional, Sgrignani, Jacopo, additional, Stefanik, Michal, additional, Hönig, Vaclav, additional, Pranclova, Veronika, additional, Michalcikova, Tereza, additional, Prochazka, Jan, additional, Guerrini, Giuditta, additional, Mehn, Dora, additional, Ciabattini, Annalisa, additional, Abolhassani, Hassan, additional, Jarrossay, David, additional, Uguccioni, Mariagrazia, additional, Medaglini, Donata, additional, Pan-Hammarström, Qiang, additional, Calzolai, Luigi, additional, Fernandez, Daniel, additional, Baldanti, Fausto, additional, Franzetti-Pellanda, Alessandra, additional, Garzoni, Christian, additional, Sedlacek, Radislav, additional, Ruzek, Daniel, additional, Varani, Luca, additional, Cavalli, Andrea, additional, Barnes, Christopher O., additional, and Robbiani, Davide F., additional

Published
2022
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44. Evolution of body weight parameters up to 3 years after solid organ transplantation: The prospective Swiss Transplant Cohort Study

Author

Beckmann, Sonja, Nikolic, Nataša, Denhaerynck, Kris, Binet, Isabelle, Koller, Michael, Boely, Elsa, De Geest, Sabina, Berben, Lut, Burkhalter, Hanna, Claes, Veerle, Helmy, Remon, Kirsch, Monika, Leppla, Lynn, Mauthner, Oliver, Struker, Marian, Boehler, Annette, Gerull, Sabine, Huynh‐Do, Uyen, Catana, Emmanuelle, Simcox, Amira, Seiler, Annina, Klaghofer, Richard, Künzler‐Heule, Patrizia, Achermann, Rita, Amico, Patrizia, Aubert, John‐David, Banz, Vanessa, Beldi, Guido, Benden, Christian, Berger, Christoph, Bochud, Pierre‐Yves, Bucher, Heiner, Bühler, Leo, Carell, Thierry, Chalandon, Yves, de Rougemont, Olivier, Dickenmann, Michael, Duchosal, Michel, Elkrief, Laure, Fehr, Thomas, Ferrari‐Lacraz, Sylvie, Garzoni, Christian, Soccal, Paola Gasche, Gaudet, Christophe, Giostra, Emiliano, Golshayan, Déla, Hadaya, Karine, Halter, Jörg, Heim, Dominik, Hess, Christoph, Hillinger, Sven, Hirsch, Hans H., Hofbauer, Günther, Immer, Franz, Laesser, Bettina, Lehmann, Roger, Lovis, Christian, Manuel, Oriol, Marti, Hans‐Peter, Martin, Pierre Yves, Meylan, Pascal, Mohacsi, Paul, Morel, Philippe, Mueller, Ulrike, Mueller, Nicolas J, Mueller‐McKenna, Helen, Müller, Antonia, Müller, Thomas, Müllhaupt, Beat, Nadal, David, Pascual, Manuel, Passweg, Jakob, Rick, Juliane, Roosnek, Eddy, Rosselet, Anne, Rothlin, Silvia, Ruschitzka, Frank, Schanz, Urs, Schaub, Stefan, Schnyder, Aurelia, Seiler, Christian, Stampf, Susanne, Steiger, Jürg, Stirnimann, Guido, Toso, Christian, Van Delden, Christian, Venetz, Jean‐Pierre, Villard, Jean, Wick, Madeleine, Wilhelm, Markus, and Yerly, Patrick

Published
2017
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45. Maturation of SARS-CoV-2 Spike-specific memory B cells drives resilience to viral escape

Author

Marzi, Roberta, primary, Bassi, Jessica, additional, Silacci-Fregni, Chiara, additional, Bartha, Istvan, additional, Muoio, Francesco, additional, Culap, Katja, additional, Sprugasci, Nicole, additional, Lombardo, Gloria, additional, Saliba, Christian, additional, Cameroni, Elisabetta, additional, Cassotta, Antonino, additional, Low, Jun Siong, additional, Walls, Alexandra C., additional, McCallum, Matthew, additional, Tortorici, M. Alejandra, additional, Bowen, John E., additional, Dellota, Exequiel A., additional, Dillen, Josh R., additional, Czudnochowski, Nadine, additional, Pertusini, Laura, additional, Terrot, Tatiana, additional, Lepori, Valentino, additional, Tarkowski, Maciej, additional, Riva, Agostino, additional, Biggiogero, Maira, additional, Pellanda, Alessandra Franzetti, additional, Garzoni, Christian, additional, Ferrari, Paolo, additional, Ceschi, Alessandro, additional, Giannini, Olivier, additional, Havenar-Daughton, Colin, additional, Telenti, Amalio, additional, Arvin, Ann, additional, Virgin, Herbert W., additional, Sallusto, Federica, additional, Veesler, David, additional, Lanzavecchia, Antonio, additional, Corti, Davide, additional, and Piccoli, Luca, additional

Published
2022
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46. ACE2-binding exposes the SARS-CoV-2 fusion peptide to broadly neutralizing coronavirus antibodies

Author

Low, Jun Siong, primary, Jerak, Josipa, additional, Tortorici, M. Alejandra, additional, McCallum, Matthew, additional, Pinto, Dora, additional, Cassotta, Antonino, additional, Foglierini, Mathilde, additional, Mele, Federico, additional, Abdelnabi, Rana, additional, Weynand, Birgit, additional, Noack, Julia, additional, Montiel-Ruiz, Martin, additional, Bianchi, Siro, additional, Benigni, Fabio, additional, Sprugasci, Nicole, additional, Joshi, Anshu, additional, Bowen, John E., additional, Stewart, Cameron, additional, Rexhepaj, Megi, additional, Walls, Alexandra C., additional, Jarrossay, David, additional, Morone, Diego, additional, Paparoditis, Philipp, additional, Garzoni, Christian, additional, Ferrari, Paolo, additional, Ceschi, Alessandro, additional, Neyts, Johan, additional, Purcell, Lisa A., additional, Snell, Gyorgy, additional, Corti, Davide, additional, Lanzavecchia, Antonio, additional, Veesler, David, additional, and Sallusto, Federica, additional

Published
2022
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47. Reply to Böning et al. Comment on “Ceruti et al. Temporal Changes in the Oxyhemoglobin Dissociation Curve of Critically Ill COVID-19 Patients. J. Clin. Med. 2022, 11, 788”

Author

Ceruti, Samuele, primary, Minotti, Bruno, additional, Glotta, Andrea, additional, Biggiogero, Maira, additional, Bona, Giovanni, additional, Marzano, Martino, additional, Greco, Pietro, additional, Spagnoletti, Marco, additional, Garzoni, Christian, additional, and Bendjelid, Karim, additional

Published
2022
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48. Bloodstream infections in allogeneic haematopoietic cell recipients from the Swiss Transplant Cohort Study

Author

Weisser, Maja, primary, Sava, Mihaela, additional, Baettig, Veronika, additional, Gerull, Sabine, additional, Passweg, Jakob, additional, Khanna, Nina, additional, Garzoni, Christian, additional, Gerber, Bernhard, additional, Mueller, Nicolas, additional, Schanz, Urs, additional, Berger, Christoph, additional, Chalandon, Yves, additional, Delden, Christian van, additional, Neofytos, Dionysios, additional, Stampf, Susanne, additional, and Franzeck, Fabian, additional

Published
2022
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49. P1245 Polymorphic Variants of HSD3B1 Gene Confer Different Outcome in Specific Subgroups of Patients Infected With SARS-CoV-2

Author

Epistolio, Samantha, primary, Ramelli, Giulia, additional, Ottaviano, Margaret, additional, Crupi, Emanuele, additional, Marandino, Laura, additional, Biggiogero, Maira, additional, Maida, Pier Andrea, additional, Ruinelli, Lorenzo, additional, Vogl, Ursula, additional, Mangan, Dylan, additional, Pascale, Mariarosa, additional, Cantù, Marco, additional, Ceschi, Alessandro, additional, Bernasconi, Enos, additional, Mazzucchelli, Luca, additional, Catapano, Carlo, additional, Alimonti, Andrea, additional, Garzoni, Christian, additional, Gillessen Sommer, Silke, additional, Stefanini, Federico Mattia, additional, Franzetti-Pellanda, Alessandra, additional, Frattini, Milo, additional, and Pereira Mestre, Ricardo, additional

Published
2022
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50. The MELD upgrade exception: a successful strategy to optimize access to liver transplantation for patients with high waiting list mortality

Author

Dirchwolf, Melisa, primary, Becchetti, Chiara, additional, Gschwend, Sarah G., additional, Toso, Christian, additional, Dutkowski, Philipp, additional, Immer, Franz, additional, Beyeler, Franziska, additional, Rossi, Simona, additional, Schropp, Jonas, additional, Dufour, Jean-François, additional, Banz, Vanessa, additional, Amico, Patrizia, additional, Axel, Andres, additional, Aubert, John-David, additional, Sonja, Beckmann, additional, Beldi, Guido, additional, Benden, Christian, additional, Berger, Christoph, additional, Binet, Isabelle, additional, Bochud, Pierre-Yves, additional, Branca, Sanda, additional, Bucher, Heiner, additional, Carrel, Thierry, additional, Catana, Emmanuelle, additional, Chalandon, Yves, additional, de Geest, Sabina, additional, de Rougemont, Olivier, additional, Dickenmann, Michael, additional, Dreifuss, Joëlle L., additional, Duchosal, Michel, additional, Fehr, Thomas, additional, Ferrari-Lacraz, Sylvie, additional, Garzoni, Christian, additional, Soccal, Paola G., additional, Gaudet, Christophe, additional, Giostra, Emiliano, additional, Golshayan, Déla, additional, Hadaya, Karine, additional, Halter, Jörg, additional, Hauri, Dimitri, additional, Heim, Dominik, additional, Hess, Christoph, additional, Hillinger, Sven, additional, Hirsch, Hans, additional, Hirt, Patricia, additional, Hofbauer, Günther, additional, Huynh-Do, Uyen, additional, Koller, Michael, additional, Laesser, Bettina, additional, Lang, Brian, additional, Lehmann, Roger, additional, Leichtle, Alexander, additional, Lovis, Christian, additional, Manuel, Oriol, additional, Marti, Hans-Peter, additional, Martin, Pierre Y., additional, Martinelli, Michele, additional, Mellac, Katell, additional, Merçay, Aurélia, additional, Mettler, Karin, additional, Meylan, Pascal, additional, Mueller, Nicolas, additional, Müller, Antonia, additional, Müller, Thomas, additional, Müller-Arndt, Ulrike, additional, Müllhaupt, Beat, additional, Nägeli, Mirjam, additional, Pascual, Manuel, additional, Posfay-Barbe, Klara, additional, Rick, Juliane, additional, Rosselet, Anne, additional, Rothlin, Silvia, additional, Ruschitzka, Frank, additional, Schanz, Urs, additional, Schaub, Stefan, additional, Schnyder, Aurelia, additional, Schuurmans, Macé, additional, Simonetta, Federico, additional, Staufer, Katharina, additional, Stampf, Susanne, additional, Steiger, Jürg, additional, Stirniman, Guido, additional, Stürzinger, Ueli, additional, Van Delden, Christian, additional, Venetz, Jean-Pierre, additional, Villard, Jean, additional, Vionnet, Julien, additional, Wick, Madeleine, additional, Wilhlem, Markus, additional, and Yerly, Patrick, additional

Published
2022
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