329 results on '"Gascoigne, Nicholas R. J."'
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2. Colonization with ubiquitous protist Blastocystis ST1 ameliorates DSS-induced colitis and promotes beneficial microbiota and immune outcomes
3. Themis suppresses the effector function of CD8+ T cells in acute viral infection
4. Lck bound to coreceptor is less active than free Lck
5. Themis regulates metabolic signaling and effector functions in CD4+ T cells by controlling NFAT nuclear translocation
6. SHP-1 Regulates CD8+ T Cell Effector Function but Plays a Subtle Role with SHP-2 in T Cell Exhaustion Due to a Stage-Specific Nonredundant Functional Relay
7. Themis-associated phosphatase activity controls signaling in T cell development
8. DUSP16 promotes cancer chemoresistance through regulation of mitochondria-mediated cell death
9. Signaling from T cell receptors (TCRs) and chimeric antigen receptors (CARs) on T cells
10. T cell receptor and cytokine signal integration in CD8+ T cells is mediated by the protein Themis
11. In silico Modeling of Itk Activation Kinetics in Thymocytes Suggests Competing Positive and Negative IP4 Mediated Feedbacks Increase Robustness
12. Defining the structural basis for human leukocyte antigen reactivity in clinical transplantation
13. Themis controls T cell activation, effector functions, and metabolism of peripheral CD8+ T cells.
14. Monomeric TCRs drive T cell antigen recognition
15. Defining the structural basis for human alloantibody binding to human leukocyte antigen allele HLA-A*11:01
16. Time required for commitment to T cell proliferation depends on TCR affinity and cytokine response
17. CD8+ T cells have commitment issues
18. IL-12/18/21 pre-activation enhances the anti-tumor efficacy of expanded γδT cells and overcomes resistance to anti-PD-L1 treatment
19. Co-Receptors and Recognition of Self at the Immunological Synapse
20. Development of a screening strategy for new modulators of T cell receptor signaling and T cell activation
21. Utilizing distinct CAR and TCR signaling to generate enhanced cellular immunotherapy
22. Themis is indispensable for IL-2 and IL-15 signaling in T cells
23. Time required for commitment to T cell proliferation depends on TCR affinity and cytokine response.
24. Non-Stimulatory pMHC Enhance CD8 T Cell Effector Functions by Recruiting Coreceptor-Bound Lck
25. Single Molecule Force Spectroscopy Reveals Distinctions in Key Biophysical Parameters of αβ T-Cell Receptors Compared with Chimeric Antigen Receptors Directed at the Same Ligand
26. Immunology Tolerance lies in the timing
27. Expansion of an Unusual Virtual Memory CD8+ Subpopulation Bearing Vα3.2 TCR in Themis-Deficient Mice
28. New insights into the interactions between Blastocystis, the gut microbiota, and host immunity
29. Targeting CAR to the Peptide-MHC Complex Reveals Distinct Signaling Compared to That of TCR in a Jurkat T Cell Model
30. Themis sets the signal threshold for positive and negative selection in T-cell development
31. TCR affinity and negative regulation limit autoimmunity
32. Themis regulates metabolic signaling and effector functions in CD4+ T cells by controlling NFAT nuclear translocation
33. Surprisingly minor influence of TRAV11 (Vα14) polymorphism on NK T-receptor mCD1/α-galactosylceramide binding kinetics
34. Co-Receptors and Recognition of Self at the Immunological Synapse
35. T cell receptor binding kinetics and special role of Vα in T cell development and activation
36. Taming the Sentinels: Microbiome-Derived Metabolites and Polarization of T Cells
37. Single Cell Analysis of Drug Susceptibility of Mycobacterium abscessus during Macrophage Infection
38. Alteration in Three-Dimensional Microenvironment of Themis-deficient Murine Thymus Using Image Cytometry Approach
39. Autoimmune responses and inflammation in type 2 diabetes
40. Thymic selection threshold defined by compartmentalization of Ras/MAPK signalling
41. Spectral Shift of Fluorescent Dye FM4-64 Reveals Distinct Microenvironment of Nuclear Envelope in Living Cells
42. Chromosome 14 in B10.A(18R) mice is recombinant and includes Tcra-V a alleles
43. A Dual Inhibitor of Cdc7/Cdk9 Potently Suppresses T Cell Activation
44. Themis integrates T cell receptor and cytokine signals in CD8+ T cells
45. Identification of Mediators of T-cell Receptor Signaling via the Screening of Chemical Inhibitor Libraries
46. DISPROPORTIONATE RECRUITMENT OF CD8+ T CELLS INTO THE CNS.
47. Expansion of an Unusual Virtual Memory CD8+ Subpopulation Bearing Vα3.2 TCR in Themis-Deficient Mice.
48. Control of MHC Restriction by TCR Valpha CDR1 and CDR2
49. T-cell-receptor affinity and thymocyte positive selection
50. Lck bound to coreceptor is less active than free Lck.
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