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Background Complex regional pain syndrome ( CRPS) is a disorder that is often challenging to treat and can be associated with a prolonged course of severe pain. Therapy of CRPS remains controversial; the pain often can be very difficult to control, and treatment includes medications, physical therapy, regional anesthesia, and neuromodulation. Aim We evaluated Scrambler Therapy® ( ST) in terms of efficacy, safety, and durability of treatment effect in patients suffering from CRPS. Materials and Methods We report the response to ST in four patients with CRPS referred to the Pain Center of Bambino Gesù Children's Hospital. The patients previously did not respond to conventional and nonconventional medical treatments. Results The treatment with ST was found effective in all four of our patients; they obtained pain relief for long periods and an improvement in their quality of life. We observed a progressive improvement with complete disappearance of neuropathic pain. Patients also reported a muscle strength increase that allowed them to resume normal daily activities. Discussion and Conclusion We conclude that ST may offer a therapeutic opportunity for patients with neuropathic pain resulting from CRPS, without side effects and with minimal discomfort during treatment. The observed pain relief indicates that ST could be an effective option for such patients. [ABSTRACT FROM AUTHOR]

Background: Complex regional pain syndrome (CRPS) is a disorder that is often challenging to treat and can be associated with a prolonged course of severe pain. Therapy of CRPS remains controversial; the pain often can be very difficult to control, and treatment includes medications, physical therapy, regional anesthesia, and neuromodulation., Aim: We evaluated Scrambler Therapy(®) (ST) in terms of efficacy, safety, and durability of treatment effect in patients suffering from CRPS., Materials and Methods: We report the response to ST in four patients with CRPS referred to the Pain Center of Bambino Gesù Children's Hospital. The patients previously did not respond to conventional and nonconventional medical treatments., Results: The treatment with ST was found effective in all four of our patients; they obtained pain relief for long periods and an improvement in their quality of life. We observed a progressive improvement with complete disappearance of neuropathic pain. Patients also reported a muscle strength increase that allowed them to resume normal daily activities., Discussion and Conclusion: We conclude that ST may offer a therapeutic opportunity for patients with neuropathic pain resulting from CRPS, without side effects and with minimal discomfort during treatment. The observed pain relief indicates that ST could be an effective option for such patients., (© 2016 World Institute of Pain.)