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2. Electrophysiological Phenotype-Genotype Study of Sustained Monomorphic Ventricular Tachycardia in Inherited, High Arrhythmic Risk, Left Ventricular Cardiomyopathy

Author

Cabrera-Borrego, Eva, Bermúdez-Jiménez, Francisco J., Gasperetti, Alessio, Tandri, Harikrishna, Sánchez-Millán, Pablo J., Molina-Lerma, Manuel, Roca-Luque, Ivo, Vázquez-Calvo, Sara, Compagnucci, Paolo, Casella, Michela, Tondo, Claudio, Peichl, Petr, Peretto, Giovani, Paiotti, Elena, Saguner, Ardan M, Castro-Urda, Víctor, Mora-Ayestarán, Nerea, Larrañaga-Moreira, José M, Fernández de-Aspe, Pablo, Barriales-Villa, Roberto, Muñoz-Esparza, Carmen, Zorio, Esther, Martínez-Solé, Julia, Lopes, Luis R., Tonko, Johanna B., Lambiase, Pier D., Elliott, Perry M., Rodríguez-Mañero, Moisés, Cañadas-Godoy, Victoria, Giacoman, Sebastian, Álvarez-López, Miguel, Macías-Ruiz, Rosa, McKenna, William J., Tercedor-Sánchez, Luis, and Jiménez-Jáimez, Juan

Published
2024
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4. Leadless pacemakers in patients with different stages of chronic kidney disease: Real-world data from the updated i-LEAPER registry

Author

Mitacchione, Gianfranco, Schiavone, Marco, Gasperetti, Alessio, Tripepi, Giovanni L., Cerini, Manuel, Montemerlo, Elisabetta, Del Monte, Alvise, Bontempi, Luca, Moltrasio, Massimo, Breitenstein, Alexander, Monaco, Cinzia, Palmisano, Pietro, Rovaris, Giovanni, Chierchia, Gian-Battista, Dello Russo, Antonio, Biffi, Mauro, de Asmundis, Carlo, Mazzone, Patrizio, Di Biase, Luigi, Gallieni, Maurizio, Tondo, Claudio, Curnis, Antonio, and Forleo, Giovanni B.

Published
2025
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5. Preprocedural imaging with cardiac computed tomography for endo-epicardial ventricular tachycardia ablation

Author

Carbucicchio, Corrado, Guarracini, Fabrizio, Schiavone, Marco, Gasperetti, Alessio, Conte, Edoardo, Preda, Alberto, Cellucci, Selene, De Iuliis, Pasquale, Catto, Valentina, Mushtaq, Saima, Mancini, Maria Elisabetta, Marchetti, Francesca, Bianchini, Lorenzo, Tundo, Fabrizio, Moltrasio, Massimo, Andreini, Daniele, Pontone, Gianluca, and Tondo, Claudio

Published
2024
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6. Abstract 4142400: Clinical implication and potential role of immunosuppression for myocarditis episodes in patients with desmoplakin cardiomyopathy: hope from the DSP-ERADOS Network?

Author

Gasperetti, Alessio, Peretto, Giovanni, Muller, Steven, Laredo, mikael, Carrick, Richard, Asatryan, Babken, Protonotarios, Alexandros, Murray, Brittney, Scheel, Paul, Pilichou, Kalliopi, Syrris, Petros, Jason, Max, Medo, Kristen, Rossi, Valentina, Saguner, Ardan, Hylind, Robyn, Abrams, Dominic, Cadrin-Tourigny, Julia, olivotto, iacopo, Biagini, Elena, Cox, Moniek, CHARRON, Philippe, Ware, James, Cal, Leonardo, smith, eric, Ingles, Jodie, Ader, Flavie, Peters, Stacey, russo, jeremy, Zentner, Dominica, Bahr, Eric, Carruth, Eric, Haggerty, Chris, Parikh, Victoria, Taylor, Matthew, Mestroni, Luisa, Sinagra, Gianfranco, Wilde, Arthur, Gandjbakhch, Estelle, Te Riele, Anneline, Van Tintelen, Peter, Elliott, Perry, Adamo, Luigi, James, Cynthia, Merlo, Marco, Lakdawala, Neal, Bauce, Barbara, Helms, Adam, Calkins, Hugh, and Gilotra, Nisha

Published
2024
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8. Substrate Characterization and Outcomes of Ventricular Tachycardia Ablation in Amyloid Cardiomyopathy: A Multicenter Study

Author

Compagnucci, Paolo, Dello Russo, Antonio, Gasperetti, Alessio, Schiavone, Marco, Sehrawat, Ojasav, Hasegawa, Kanae, Mohanty, Sanghamitra, Liang, Jackson J., Kapa, Suraj, La Fazia, Vincenzo Mirco, Bogun, Frank, Stevenson, William G., Tondo, Claudio, Siontis, Konstantinos C., Tandri, Harikrishna, Santangeli, Pasquale, Natale, Andrea, and Casella, Michela

Published
2024
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10. Eighteen‐Month Real‐World Experience Using Mavacamten for Treatment of Obstructive Hypertrophic Cardiomyopathy in a Racially Diverse Population

Author

Diego Ramonfaur, Alessio Gasperetti, Victoria E. Blake, Bryana Rivers, Ali A. Kassamali, Edward K. Kasper, Lili A. Barouch, Katherine C. Wu, Jose A. Madrazo, and Richard T. Carrick

Subjects
echocardiography, hypertrophic cardiomyopathy, LVOT obstruction, mavacamten, obesity, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Background Patients with obstructive hypertrophic cardiomyopathy have increased symptomatic burden. Mavacamten was recently approved for treatment of obstructive hypertrophic cardiomyopathy based on 2 randomized controlled trials. However, its use under real‐world conditions and in diverse populations is under‐studied. Methods and Results This was a prospective observational cohort study of patients seen at the Johns Hopkins HCM center and prescribed mavacamten for obstructive hypertrophic cardiomyopathy between July 7, 2022 and January 6, 2024. Patients were followed longitudinally, with serial echocardiography and clinical evaluation as mandated by the risk evaluation and mitigation strategy program. Sixty‐six patients received mavacamten (mean age 59 years, 47% male, 29% non‐White [Black, Hispanic/Latino, Asian, Native Hawaiian or Pacific Islander], 47% obese). Before treatment, all patients had New York Heart Association class II (51.5%) or III (48.5%) heart failure symptoms. Initial maximum peak left ventricular outflow tract gradient was 107±46 mm Hg. Median treatment duration was 9 months. For patients on mavacamten after ≥6 months (n=43), symptoms improved by ≥1 New York Heart Association class in 72% of patients, and peak left ventricular outflow tract gradient decreased by 80±46 mm Hg, eliminating hemodynamically significant left ventricular outflow tract obstruction in 79.1% of patients. Mavacamten was temporarily discontinued in 3 patients due to left ventricular ejection fraction decrease

Published
2024
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13. Left Atrial Appendage Occlusion in Patients With Anticoagulation Failure vs Anticoagulation Contraindication

Author

Aarnink, Errol W., Maarse, Moniek, Fierro, Nicolai, Mazzone, Patrizio, Beneduce, Alessandro, Tondo, Claudio, Gasperetti, Alessio, Pracon, Radoslaw, Demkow, Marcin, Zieliński, Kamil, de Backer, Ole, Korsholm, Kasper, Nielsen-Kudsk, Jens Erik, Estévez-Loureiro, Rodrigo, Caneiro-Queija, Berenice, Benito-González, Tomás, Pérez de Prado, Armando, Nombela-Franco, Luis, Salinas, Pablo, Holmes, David, Almakadma, Abdul H., Berti, Sergio, Romeo, Maria Rita, Millan, Xavier, Arzamendi, Dabit, Alla, Venkata M., Agarwal, Himanshu, Eitel, Ingo, Paitazoglou, Christina, Freixa, Xavier, Cepas-Guillén, Pedro, Chothia, Rashaad, Badejoko, Solomon O., Spoon, Daniel B., Maddux, James T., El-Chami, Mikhael, Ram, Pradhum, Branca, Luca, Adamo, Marianna, Suradi, Hussam S., Peper, Joyce, van Dijk, Vincent F., Rensing, Benno J.W.M., Swaans, Martin J., Vireca, Elisa, Bergmann, Martin W., and Boersma, Lucas V.A.

Published
2024
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14. Differences in underlying cardiac substrate among S-ICD recipients and its impact on long-term device-related outcomes: Real-world insights from the iSUSI registry

Author

Gasperetti, A., Arosio, R., Viecca, M., Forleo, G.B., Schiavone, M., Tondo, C., Ziacchi, M., Diemberger, I., Angeletti, A., Biffi, M., Fierro, N., Gulletta, S., Della Bella, P., Curnis, G. Mitacchione.A., Compagnucci, P., Casella, M., Russo, A. Dello, Santini, L., Pignalberi, C., Magnocavallo, M., Piro, A., Lavalle, C., Picarelli, F., Ricciardi, D., Bressi, E., Calò, L., Montemerlo, E., Rovaris, G., De Bonis, S., Bisignani, A., Bisignani, G., Russo, G., Pisanò, E., Palmisano, P., Guarracini, F., Vitali, F., Bertini, M., Vogler, J., Fink, T., Tilz, R., Fastenrath, F., Kuschyk, J., Kaiser, L., Hakmi, S., Laredo, M., Waintraub, X., Gandjbakhch, E., Badenco, N., Breitenstein, A., Saguner, A.M., Martine, M., Seidl, S., Di Biase, L., Gasperetti, Alessio, Schiavone, Marco, Milstein, Jenna, Compagnucci, Paolo, Vogler, Julia, Laredo, Mikael, Breitenstein, Alexander, Gulletta, Simone, Martinek, Martin, Casella, Michela, Kaiser, Lukas, Santini, Luca, Rovaris, Giovanni, Curnis, Antonio, Biffi, Mauro, Kuschyk, Jürgen, Di Biase, Luigi, Tilz, Roland, Tondo, Claudio, and Forleo, Giovanni B.

Published
2024
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15. Left ventricular assist device in the presence of subcutaneous implantable cardioverter defibrillator: Data from a multicenter experience

Author

Migliore, Federico, Schiavone, Marco, Pittorru, Raimondo, Forleo, Giovanni B., De Lazzari, Manuel, Mitacchione, Gianfranco, Biffi, Mauro, Gulletta, Simone, Kuschyk, Jurgen, Dall'Aglio, Pietro Bernardo, Rovaris, Giovanni, Tilz, Roland, Mastro, Florinda Rosaria, Iliceto, Sabino, Tondo, Claudio, Di Biase, Luigi, Gasperetti, Alessio, Tarzia, Vincenzo, and Gerosa, Gino

Published
2024
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16. Long-Term Arrhythmic Follow-Up and Risk Stratification of Patients With Desmoplakin-Associated Arrhythmogenic Right Ventricular Cardiomyopathy

Author

Gasperetti, Alessio, Carrick, Richard, Protonotarios, Alexandros, Laredo, Mikael, van der Schaaf, Iris, Syrris, Petros, Murray, Brittney, Tichnell, Crystal, Cappelletto, Chiara, Gigli, Marta, Medo, Kristen, Crabtree, Peter, Saguner, Ardan M., Duru, Firat, Hylind, Robyn, Abrams, Dominic, Lakdawala, Neal K., Massie, Charles, Cadrin-Tourigny, Julia, Targetti, Mattia, Olivotto, Iacopo, Graziosi, Maddalena, Cox, Moniek, Biagini, Elena, Charron, Philippe, Casella, Michela, Tondo, Claudio, Yazdani, Momina, Ware, James S., Prasad, Sanjay, Calò, Leonardo, Smith, Eric, Helms, Adam, Hespe, Sophie, Ingles, Jodie, Tandri, Harikrishna, Ader, Flavie, Mestroni, Luisa, Wilde, Arthur, Merlo, Marco, Gandjbakhch, Estelle, Calkins, Hugh, te Riele, Anneline S.J.M., Peter van Tintelen, J., Elliot, Perry, and James, Cynthia A.

Published
2024
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17. Catheter Ablation for Ventricular Tachycardia in Patients With Desmoplakin Cardiomyopathy

Author

Gasperetti, Alessio, Peretto, Giovanni, Muller, Steven A., Hasegawa, Kanae, Compagnucci, Paolo, Casella, Michela, Murray, Brittney, Tichnell, Crystal, Carrick, Richard T., Cadrin-Tourigny, Julia, Schiavone, Marco, James, Cynthia, Amin, Ahmad S., Saguner, Ardan M., Dello Russo, Antonio, Tondo, Claudio, Stevenson, William, Della Bella, Paolo, Calkins, Hugh, and Tandri, Harikrishna

Published
2024
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19. Long-Term Performance of Subcutaneous Implantable Defibrillators in Athletes: A Multicenter, Real-World Analysis of Sport Activities from the iSUSI Registry

Author

Gasperetti, Alessio, Schiavone, Marco, Vogler, Julia, Compagnucci, Paolo, Laredo, Mikael, Breitenstein, Alexander, Gulletta, Simone, Martinek, Martin, Kaiser, Lukas, Lavalle, Carlo, Gaine, Sean, Santini, Luca, Dello Russo, Antonio, Palmisano, Pietro, Rovaris, Giovanni, Curnis, Antonio, Ventrella, Nicoletta, Kuschyk, Jürgen, Biffi, Mauro, Tilz, Roland, Di Biase, Luigi, Tondo, Claudio, and Forleo, Giovanni B.

Published
2024
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21. Diagnostic value of late gadolinium enhancement at cardiovascular magnetic resonance to distinguish arrhythmogenic right ventricular cardiomyopathy from differentials

Author

Rekker, Lian Y., Muller, Steven A., Gasperetti, Alessio, Bourfiss, Mimount, Oerlemans, Marish I.F.J., Cramer, Maarten J., Zimmerman, Stefan L., Dooijes, Dennis, Schalkx, Hanke, van der Harst, Pim, James, Cynthia A., van Tintelen, J. Peter, Guglielmo, Marco, Velthuis, Birgitta K., and te Riele, Anneline S.J.M.

Published
2024
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22. The Diagnostic Value of the 12-Lead ECG in Arrhythmogenic Left Ventricular Cardiomyopathy: Novel ECG Signs

Author

Calò, Leonardo, Crescenzi, Cinzia, Martino, Annamaria, Casella, Michela, Romeo, Fabiana, Cappelletto, Chiara, Bressi, Edoardo, Panattoni, Germana, Stolfo, Davide, Targetti, Mattia, Toso, Elisabetta, Musumeci, Maria Beatrice, Tini, Giacomo, Ciabatti, Michele, Stefanini, Matteo, Silvetti, Elisa, Stazi, Alessandra, Danza, Maria Ludovica, Rebecchi, Marco, Canestrelli, Stefano, Fedele, Elisa, Lanzillo, Chiara, Fusco, Armando, Sangiuolo, Federica Carla, Oliviero, Giada, Radesich, Cinzia, Perotto, Maria, Pieroni, Maurizio, Golia, Paolo, Mango, Ruggiero, Gasperetti, Alessio, Autore, Camillo, Merlo, Marco, de Ruvo, Ermenegildo, Russo, Antonio Dello, Olivotto, Iacopo, Sinagra, Gianfranco, and Gaita, Fiorenzo

Published
2023
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24. Sex differences in leadless pacemaker implantation: A propensity-matched analysis from the i-LEAPER registry

Author

Mitacchione, Gianfranco, Schiavone, Marco, Gasperetti, Alessio, Arabia, Gianmarco, Tundo, Fabrizio, Breitenstein, Alexander, Montemerlo, Elisabetta, Monaco, Cinzia, Gulletta, Simone, Palmisano, Pietro, Hofer, Daniel, Rovaris, Giovanni, Dello Russo, Antonio, Biffi, Mauro, Pisanò, Ennio C.L., Della Bella, Paolo, Di Biase, Luigi, Chierchia, Gian Battista, Saguner, Ardan M., Tondo, Claudio, Curnis, Antonio, and Forleo, Giovanni B.

Published
2023
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27. Outcomes of leadless pacemaker implantation following transvenous lead extraction in high-volume referral centers: Real-world data from a large international registry

Author

Mitacchione, Gianfranco, Schiavone, Marco, Gasperetti, Alessio, Arabia, Gianmarco, Breitenstein, Alexander, Cerini, Manuel, Palmisano, Pietro, Montemerlo, Elisabetta, Ziacchi, Matteo, Gulletta, Simone, Salghetti, Francesca, Russo, Giulia, Monaco, Cinzia, Mazzone, Patrizio, Hofer, Daniel, Tundo, Fabrizio, Rovaris, Giovanni, Russo, Antonio Dello, Biffi, Mauro, Pisanò, Ennio C.L., Chierchia, Gian Battista, Della Bella, Paolo, de Asmundis, Carlo, Saguner, Ardan M., Tondo, Claudio, Forleo, Giovanni B., and Curnis, Antonio

Published
2023
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28. Predicting ventricular tachycardia circuits in patients with arrhythmogenic right ventricular cardiomyopathy using genotype-specific heart digital twins

Author

Yingnan Zhang, Kelly Zhang, Adityo Prakosa, Cynthia James, Stefan L Zimmerman, Richard Carrick, Eric Sung, Alessio Gasperetti, Crystal Tichnell, Brittney Murray, Hugh Calkins, and Natalia A Trayanova

Subjects
electrophysiology, cardiomyopathy, genetics, ventricular arrhythmia, computer modeling, cardiac imaging, Medicine, Science, Biology (General), QH301-705.5
Abstract

Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a genetic cardiac disease that leads to ventricular tachycardia (VT), a life-threatening heart rhythm disorder. Treating ARVC remains challenging due to the complex underlying arrhythmogenic mechanisms, which involve structural and electrophysiological (EP) remodeling. Here, we developed a novel genotype-specific heart digital twin (Geno-DT) approach to investigate the role of pathophysiological remodeling in sustaining VT reentrant circuits and to predict the VT circuits in ARVC patients of different genotypes. This approach integrates the patient’s disease-induced structural remodeling reconstructed from contrast-enhanced magnetic-resonance imaging and genotype-specific cellular EP properties. In our retrospective study of 16 ARVC patients with two genotypes: plakophilin-2 (PKP2, n = 8) and gene-elusive (GE, n = 8), we found that Geno-DT accurately and non-invasively predicted the VT circuit locations for both genotypes (with 100%, 94%, 96% sensitivity, specificity, and accuracy for GE patient group, and 86%, 90%, 89% sensitivity, specificity, and accuracy for PKP2 patient group), when compared to VT circuit locations identified during clinical EP studies. Moreover, our results revealed that the underlying VT mechanisms differ among ARVC genotypes. We determined that in GE patients, fibrotic remodeling is the primary contributor to VT circuits, while in PKP2 patients, slowed conduction velocity and altered restitution properties of cardiac tissue, in addition to the structural substrate, are directly responsible for the formation of VT circuits. Our novel Geno-DT approach has the potential to augment therapeutic precision in the clinical setting and lead to more personalized treatment strategies in ARVC.

Published
2023
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29. Pre-Excited Atrial Fibrillation in Wolff-Parkinson-White (WPW) Syndrome: A Case Report and a Review of the Literature

Author

Marco Schiavone, Annalisa Filtz, Alessio Gasperetti, Xiaodong Zhang, Giovanni B. Forleo, Pasquale Santangeli, and Luigi Di Biase

Subjects
pre-excited atrial fibrillation, wolff-parkinson-white syndrome, accessory pathway, antiarrhythmic drugs, catheter ablation, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Wolff-Parkinson-White (WPW) syndrome is defined by specific electrocardiogram (ECG) changes resulting in ventricular pre-excitation (the so-called WPW pattern), related to the presence of an accessory pathway (AP), combined with recurrent tachyarrhythmias. WPW syndrome is characterized by different supraventricular tachyarrhythmias (SVT), including atrioventricular re-entry tachycardia (AVRT) and atrial fibrillation (AF) with rapid ventricular response, with AVRT being the most common arrhythmia associated with WPW, and AF occurring in up to 50% of patients with WPW. Several mechanisms might be responsible for AF development in the WPW syndrome, and a proper electrocardiographic interpretation is of pivotal importance since misdiagnosing pre-excited AF could lead to the administration of incorrect treatment, potentially inducing ventricular fibrillation (VF). Great awareness of pre-excited AF’s common ECG characteristics as well as associated causes and its treatment is needed to increase diagnostic performance and improve patients’ outcomes. In the present review, starting from a paradigmatic case, we discuss the characteristics of pre-excited AF in the emergency department and its management, focusing on the most common ECG abnormalities, pharmacological and invasive treatment of this rhythm disorder.

Published
2024
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30. Peri-procedural and mid-term follow-up age-related differences in leadless pacemaker implantation: Insights from a multicenter European registry

Author

Gulletta, Simone, Schiavone, Marco, Gasperetti, Alessio, Breitenstein, Alexander, Palmisano, Pietro, Mitacchione, Gianfranco, Chierchia, Gian Battista, Montemerlo, Elisabetta, Statuto, Giovanni, Russo, Giulia, Casella, Michela, Vitali, Francesco, Mazzone, Patrizio, Hofer, Daniel, Arabia, Gianmarco, Moltrasio, Massimo, Lipartiti, Felicia, Fierro, Nicolai, Bertini, Matteo, Dello Russo, Antonio, Pisanò, Ennio C.L., Biffi, Mauro, Rovaris, Giovanni, de Asmundis, Carlo, Tondo, Claudio, Curnis, Antonio, Della Bella, Paolo, Saguner, Ardan M., and Forleo, Giovanni B.

Published
2023
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32. The need for a subsequent transvenous system in patients implanted with subcutaneous implantable cardioverter-defibrillator

Author

Gasperetti, Alessio, Schiavone, Marco, Vogler, Julia, Laredo, Mikael, Fastenrath, Fabian, Palmisano, Pietro, Ziacchi, Matteo, Angeletti, Andrea, Mitacchione, Gianfranco, Kaiser, Lukas, Compagnucci, Paolo, Breitenstein, Alexander, Arosio, Roberto, Vitali, Francesco, De Bonis, Silvana, Picarelli, Francesco, Casella, Michela, Santini, Luca, Pignalberi, Carlo, Lavalle, Carlo, Pisanò, Ennio, Ricciardi, Danilo, Calò, Leonardo, Curnis, Antonio, Bertini, Matteo, Gulletta, Simone, Dello Russo, Antonio, Badenco, Nicolas, Tondo, Claudio, Kuschyk, Jürgen, Tilz, Roland, Forleo, Giovanni B., and Biffi, Mauro

Published
2022
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35. Age-related differences and associated mid-term outcomes of subcutaneous implantable cardioverter-defibrillators: A propensity-matched analysis from a multicenter European registry

Author

Gulletta, Simone, Gasperetti, Alessio, Schiavone, Marco, Vogler, Julia, Fastenrath, Fabian, Breitenstein, Alexander, Laredo, Mikael, Palmisano, Pietro, Mitacchione, Gianfranco, Compagnucci, Paolo, Kaiser, Lukas, Hakmi, Samer, Angeletti, Andrea, De Bonis, Silvana, Picarelli, Francesco, Arosio, Roberto, Casella, Michela, Steffel, Jan, Fierro, Nicolai, Guarracini, Fabrizio, Santini, Luca, Pignalberi, Carlo, Piro, Agostino, Lavalle, Carlo, Pisanò, Ennio, Viecca, Maurizio, Curnis, Antonio, Badenco, Nicolas, Ricciardi, Danilo, Dello Russo, Antonio, Tondo, Claudio, Kuschyk, Jürgen, Della Bella, Paolo, Biffi, Mauro, Forleo, Giovanni B., and Tilz, Roland

Published
2022
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36. Clinical features and outcomes in carriers of pathogenic desmoplakin variants.

Author

Gasperetti, Alessio, Carrick, Richard T, Protonotarios, Alexandros, Murray, Brittney, Laredo, Mikael, van der Schaaf, Iris, Lekanne, Ronald H, Syrris, Petros, Cannie, Douglas, Tichnell, Crystal, Cappelletto, Chiara, Gigli, Marta, Medo, Kristen, Saguner, Ardan M, Duru, Firat, Gilotra, Nisha A, Zimmerman, Stefan, Hylind, Robyn, Abrams, Dominic J, and Lakdawala, Neal K

Subjects
ARRHYTHMOGENIC right ventricular dysplasia, DILATED cardiomyopathy, VENTRICULAR tachycardia, MYOCARDIAL injury, VENTRICULAR arrhythmia
Abstract

Background and Aims Pathogenic variants in the desmoplakin (DSP) gene are associated with the development of a distinct arrhythmogenic cardiomyopathy phenotype not fully captured by either dilated cardiomyopathy (DCM), non-dilated left ventricular cardiomyopathy (NDLVC), or arrhythmogenic right ventricular cardiomyopathy (ARVC). Prior studies have described baseline DSP cardiomyopathy genetic, inflammatory, and structural characteristics. However, cohort sizes have limited full clinical characterization and identification of clinical and demographic predictors of sustained ventricular arrhythmias (VAs), heart failure (HF) hospitalizations, and transplant/death. In particular, the relevance of acute myocarditis-like episodes for subsequent disease course is largely unknown. Methods All patients with pathogenic/likely pathogenic (P/LP) DSP variants in the worldwide DSP -ERADOS Network (26 academic institutions across nine countries) were included. The primary outcomes were the development of sustained VA and HF hospitalizations during follow-up. Fine–Gray regressions were used to test association between clinical and instrumental parameters and the development of outcomes. Results Eight hundred patients [40.3 ± 17.5 years, 47.5% probands, left ventricular ejection fraction (LVEF) 49.5 ± 13.9%] were included. Over 3.7 [1.4–7.1] years, 139 (17.4%, 3.9%/year) and 72 (9.0%, 1.8%/year) patients experienced sustained VA and HF episodes, respectively. A total of 32.5% of individuals did not fulfil diagnostic criteria for ARVC, DCM, or NDLVC; their VA incidence was 0.5%/year. In multivariable regression, risk features associated with the development of VA were female sex [adjusted hazard ratio (aHR) 1.547; P =.025], prior non-sustained ventricular tachycardia (aHR 1.721; P =.009), prior sustained VA (aHR 1.923; P =.006), and LVEF ≤ 50% (aHR: 1.645; P =.032), while for HF, they were the presence of T-wave inversion in 3+ electrocardiogram leads (aHR 2.036, P =.007) and LVEF ≤ 50% (aHR 3.879; P <.001). Additionally, 70 (8.8%) patients experienced a myocardial injury episode at presentation or during follow-up. These episodes were associated with an increased risk of VA and HF thereafter (HR 2.394; P <.001, and HR 5.064, P <.001, respectively). Conclusions Patients with P/LP DSP variants experience high rates of sustained VA and HF hospitalizations. These patients demonstrate a distinct clinical phenotype (DSP cardiomyopathy), whose most prominent risk features associated with adverse clinical outcomes are the presence of prior non-sustained ventricular tachycardia or sustained VA, T-wave inversion in 3+ leads on electrocardiogram, LVEF ≤ 50%, and myocardial injury events. [ABSTRACT FROM AUTHOR]

Published
2025
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42. Implantation of cardiac electronic devices in active COVID-19 patients: Results from an international survey

Author

Tovia-Brodie, Oholi, Rav Acha, Moshe, Belhassen, Bernard, Gasperetti, Alessio, Schiavone, Marco, Forleo, Giovanni Battista, Guevara-Valdivia, Milton E., Ruiz, David Valdeolivar, Lellouche, Nicolas, Hamon, David, Castagno, Davide, Bellettini, Matteo, De Ferrari, Gaetano M., Laredo, Mikael, Carvès, Jean-Baptiste, Ignatiuk, Barbara, Pasquetto, Giampaolo, De Filippo, Paolo, Malanchini, Giovanni, Pavri, Behzad B., Raphael, Craig, Rivetti, Luigi, Mantovan, Roberto, Chinitz, Jason, Harding, Melissa, Boriani, Giuseppe, Casali, Edoardo, Wan, Elaine Y., Biviano, Angelo, Macias, Carlos, Havranek, Stepan, Lazzerini, Pietro Enea, Canu, Antonio M., Zardini, Marco, Conte, Giulio, Cano, Óscar, Casella, Michela, Rudic, Boris, Omelchenko, Alexander, Mathuria, Nilesh, Upadhyay, Gaurav A., Danon, Asaf, Schwartz, Arie Lorin, Maury, Philippe, Nakahara, Shiro, Goldenberg, Gustavo, Schaerli, Nicolas, Bereza, Sergiy, Auricchio, Angelo, Glikson, Michael, and Michowitz, Yoav

Published
2022
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43. Ventricular arrhythmias in athletes: Role of a comprehensive diagnostic workup

Author

Dello Russo, Antonio, Compagnucci, Paolo, Casella, Michela, Gasperetti, Alessio, Riva, Stefania, Dessanai, Maria Antonietta, Pizzamiglio, Francesca, Catto, Valentina, Guerra, Federico, Stronati, Giulia, Andreini, Daniele, Pontone, Gianluca, Bonomi, Alice, Rizzo, Stefania, Di Biase, Luigi, Capucci, Alessandro, Natale, Andrea, Basso, Cristina, Fiorentini, Cesare, Zeppilli, Paolo, and Tondo, Claudio

Published
2022
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45. Subcutaneous implantable cardioverter-defibrillator and defibrillation testing: A propensity-matched pilot study

Author

Forleo, Giovanni B., Gasperetti, Alessio, Breitenstein, Alexander, Laredo, Mikael, Schiavone, Marco, Ziacchi, Matteo, Vogler, Julia, Ricciardi, Danilo, Palmisano, Pietro, Piro, Agostino, Compagnucci, Paolo, Waintraub, Xavier, Mitacchione, Gianfranco, Carrassa, Gianmarco, Russo, Giulia, De Bonis, Silvana, Angeletti, Andrea, Bisignani, Antonio, Picarelli, Francesco, Casella, Michela, Bressi, Edoardo, Rovaris, Giovanni, Calò, Leonardo, Santini, Luca, Pignalberi, Carlo, Lavalle, Carlo, Viecca, Maurizio, Pisanò, Ennio, Olivotto, Iacopo, Curnis, Antonio, Dello Russo, Antonio, Tondo, Claudio, Love, Charles J., Di Biase, Luigi, Steffel, Jan, Tilz, Roland, Badenco, Nicolas, and Biffi, Mauro

Published
2021
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46. Long-term complications in patients implanted with subcutaneous implantable cardioverter-defibrillators: Real-world data from the extended ELISIR experience

Author

Gasperetti, Alessio, Schiavone, Marco, Ziacchi, Matteo, Vogler, Julia, Breitenstein, Alexander, Laredo, Mikael, Palmisano, Pietro, Ricciardi, Danilo, Mitacchione, Gianfranco, Compagnucci, Paolo, Bisignani, Antonio, Angeletti, Andrea, Casella, Michela, Picarelli, Francesco, Fink, Thomas, Kaiser, Lukas, Hakmi, Samer, Calò, Leonardò, Pignalberi, Carlo, Santini, Luca, Lavalle, Carlo, Pisanò, Ennio, Olivotto, Iacopo, Tondo, Claudio, Curnis, Antonio, Dello Russo, Antonio, Badenco, Nicolas, Steffel, Jan, Love, Charles J., Tilz, Roland, Forleo, Giovanni, and Biffi, Mauro

Published
2021
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49. Additional diagnostic value of cardiac magnetic resonance feature tracking in patients with biopsy-proven arrhythmogenic cardiomyopathy

Author

Muscogiuri, Giuseppe, Fusini, Laura, Ricci, Francesca, Sicuso, Rita, Guglielmo, Marco, Baggiano, Andrea, Gasperetti, Alessio, Casella, Michela, Mushtaq, Saima, Conte, Edoardo, Annoni, Andrea, Formenti, Alberto, Mancini, Maria Elisabetta, Babbaro, Mario, Mollace, Rocco, Collevecchio, Ada, Scafuri, Stefano, Kukavica, Deni, Andreini, Daniele, Basso, Cristina, Rizzo, Stefania, De Gaspari, Monica, Priori, Silvia, Dello Russo, Antonio, Tondo, Claudio, Pepi, Mauro, Sommariva, Elena, Rabbat, Mark, Guaricci, Andrea Igoren, and Pontone, Gianluca

Published
2021
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50. Long-Term Outcomes of Near-Zero Radiation Ablation of Paroxysmal Supraventricular Tachycardia: A Comparison With Fluoroscopy-Guided Approach

Author

Bergonti, Marco, Dello Russo, Antonio, Sicuso, Rita, Ribatti, Valentina, Compagnucci, Paolo, Catto, Valentina, Gasperetti, Alessio, Zucchetti, Martina, Cellucci, Selene, Vettor, Giulia, Dessanai, Maria Antonietta, Majocchi, Benedetta, Moltrasio, Massimo, Russo, Eleonora, Stronati, Giulia, Guerra, Federico, Di Biase, Luigi, Natale, Andrea, Tondo, Claudio, and Casella, Michela

Published
2021
Full Text
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