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Rapid emissions reductions, including reductions in deforestation-based land emissions, are the dominant source of global climate mitigation potential in the coming decades. However, carbon dioxide removal (CDR) will also have an important role to play. Despite this, it remains unclear whether current national proposals for CDR align with temperature targets. Here we show the ‘CDR gap’, that is, CDR efforts proposed by countries fall short of those in integrated assessment model scenarios that limit warming to 1.5 °C. However, the most ambitious proposals for CDR are close to levels in a low-energy demand scenario with the most-limited CDR scaling and aggressive near-term emissions reductions. Further, we observe that many countries propose to expand land-based removals, but none yet commit to substantively scaling novel methods such as bioenergy carbon capture and storage, biochar or direct air carbon capture and storage.

Meeting the Paris Agreement targets requires deep emissions reductions supported by a scale-up in carbon dioxide removal. However, current country-reported mitigation pledges are off track to meet carbon dioxide removal needs, unless countries dramatically reduce emissions consistent with low-energy-demand scenarios.

Each run of an integrated assessment models produces a single mitigation pathway consistent with stated objectives (e.g. maximum temperature) and optimizing some objective function (e.g. minimizing total discounted costs of mitigation). Even though models can be run thousands of times, it is unclear how built-in assumptions constrain the final set of pathways. Here we aim at broadly exploring the space of possible mitigation scenarios for a given mitigation target, and at characterizing the sets of pathways that are (near-)optimal, taking uncertainties into account. We produce an extensive set of CO2 emission pathways that stay below 2 °C of warming using a reduced-form climate-carbon model with a 1000 different physical states. We then identify 18 sets of quasi 'least-cost' mitigation pathways, under six assumptions about cost functions and three different cost minimization functions embarking different visions of intergenerational cost distribution. A first key outcome is that the absence or presence of inertia in the cost function plays a pivotal role in the resulting set of least-cost pathways. Second, despite inherent structural differences, we find common pathways across the 18 combinations in 96% of the physical states studied. Interpreting these common pathways as robust economically and in terms of intergenerational distribution, we shed light on some of their characteristics, even though these robust pathways differ for each physical state.

Global mitigation pathways play a critical role in informing climate policies and targets that are in line with international climate goals. However, it is not possible to directly compare modelled results with national inventories used to assess progress under the UNFCCC due to differences in how land-based fluxes are accounted for. National inventories consider carbon flux on managed land using an area-based approach with managed land-areas determined by nations. Emissions scenarios consider a different managed land area and are calibrated against data from detailed global carbon cycle models that account for natural (indirect) and anthropogenic (direct) fluxes separately by design. To disentangle the direct and indirect components of land-based carbon fluxes, we use a reduced complexity climate model with explicit treatment of the land-use sector, OSCAR, one of the models used by the Global Carbon Project. We find the discrepancy between model and NGHGI-based accounting methods globally to be 4.4 ± 1.0 Gt CO2 yr-1 averaged over the 2000-2020 time period, which is in line with existing estimates. We then apply OSCAR to the set of pathways assessed by the IPCC to quantify how this gap evolves over time and estimate how key mitigation benchmarks change. Across both 1.5°C and 2°C scenarios, LULUCF emissions pathways aligned with NGHGI accounting practices show a strong increase in the total land sink until around mid-century. However, the ‘NGHGI alignment gap’ decreases over this period, converging in the 2050-2060s for 1.5°C scenarios and 2070s-2080s for 2°C scenarios. The convergence is primarily a result of the simulated stabilization and then decrease of the CO2-fertilization effect as well as background climate warming reducing the overall effectiveness of the land sink, which in turn reduces the indirect removals considered by NGHGIs. These dynamics lead to land-based emissions reversing their downward trend in most NGHGI-aligned scenarios by mid-century, and r

Background: Epidemiological studies that examined the association between Parkinson's disease (PD) and cancers led to inconsistent results, but they face a number of methodological difficulties. Objective: We used results from genome-wide association studies (GWASs) to study the genetic correlation between PD and different cancers to identify common genetic risk factors. Methods: We used individual data for participants of European ancestry from the Courage-PD (Comprehensive Unbiased Risk Factor Assessment for Genetics and Environment in Parkinson's Disease; PD, N = 16,519) and EPITHYR (differentiated thyroid cancer, N = 3527) consortia and summary statistics of GWASs from iPDGC (International Parkinson Disease Genomics Consortium; PD, N = 482,730), Melanoma Meta-Analysis Consortium (MMAC), Breast Cancer Association Consortium (breast cancer), the Prostate Cancer Association Group to Investigate Cancer Associated Alterations in the Genome (prostate cancer), International Lung Cancer Consortium (lung cancer), and Ovarian Cancer Association Consortium (ovarian cancer) (N comprised between 36,017 and 228,951 for cancer GWASs). We estimated the genetic correlation between PD and cancers using linkage disequilibrium score regression. We studied the association between PD and polymorphisms associated with cancers, and vice versa, using cross-phenotypes polygenic risk score (PRS) analyses. Results: We confirmed a previously reported positive genetic correlation of PD with melanoma (Gcorr = 0.16 [0.04; 0.28]) and reported an additional significant positive correlation of PD with prostate cancer (Gcorr = 0.11 [0.03; 0.19]). There was a significant inverse association between the PRS for ovarian cancer and PD (odds ratio [OR] = 0.89 [0.84; 0.94]). Conversely, the PRS of PD was positively associated with breast cancer (OR = 1.08 [1.06; 1.10]) and inversely associated with ovarian cancer (OR = 0.95 [0.91; 0.99]). The association between PD and ovarian cancer was mostly driven b