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3. Clinical Outcomes After Total Pancreatectomy: A Prospective Multicenter Pan-European Snapshot Study

Author

Latenstein, Anouk E.J., Scholten, Lianne, Al-Saffar, Hasan Ahmad, Björnsson, Bergthor, Butturini, Giovanni, Capretti, Giovanni, Chatzizacharias, Nikolaos A., Dervenis, Chris, Frigerio, Isabella, Gallagher, Tom K., Gasteiger, Silvia, Halimi, Asif, Labori, Knut J., Montagnini, Greta, Muñoz-Bellvis, Luis, Nappo, Gennaro, Nikov, Andrej, Pando, Elizabeth, Pastena, Matteo de, Peña-Moral, Jesús M. de la, Radenkovic, Dejan, Roberts, Keith J., Salvia, Roberto, Sanchez-Bueno, Francisco, Scandavini, Chiara, Serradilla-Martin, Mario, Stättner, Stefan, Tomazic, Ales, Varga, Martin, Zavrtanik, Hana, Zerbi, Alessandro, Erkan, Mert, Kleeff, Jörg, Lesurtel, Mickaël, Besselink, Marc G., and Ramia-Angel, Jose M.

Published
2022
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5. The Interplay between Perioperative Oxidative Stress and Hepatic Dysfunction after Human Liver Resection: A Prospective Observational Pilot Study

Author

Primavesi, Florian, primary, Senoner, Thomas, additional, Schindler, Sophie, additional, Nikolajevic, Aleksandar, additional, Di Fazio, Pietro, additional, Csukovich, Georg, additional, Eller, Silvia, additional, Neumayer, Bettina, additional, Anliker, Markus, additional, Braunwarth, Eva, additional, Oberhuber, Rupert, additional, Resch, Thomas, additional, Maglione, Manuel, additional, Cardini, Benno, additional, Niederwieser, Thomas, additional, Gasteiger, Silvia, additional, Klieser, Eckhard, additional, Tilg, Herbert, additional, Schneeberger, Stefan, additional, Neureiter, Daniel, additional, Öfner, Dietmar, additional, Troppmair, Jakob, additional, and Stättner, Stefan, additional

Published
2024
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6. Clinical Outcomes after Total Pancreatectomy: A Prospective Multicenter Pan-European Snapshot Study

Author

Latenstein, Anouk E. J., Scholten, Lianne, Al-Saffar, Hasan Ahmad, Björnsson, Bergthor, Butturini, Giovanni, Capretti, Giovanni, Chatzizacharias, Nikolaos A., Dervenis, Chris, Frigerio, Isabella, Gallagher, Tom K., Gasteiger, Silvia, Halimi, Asif, Labori, Knut J., Montagnini, Greta, Muñoz-Bellvis, Luis, Nappo, Gennaro, Nikov, Andrej, Pando, Elizabeth, de Pastena, Matteo, de la Peña-Moral, Jesús M., Radenkovic, Dejan, Roberts, Keith J., Salvia, Roberto, Sanchez-Bueno, Francisco, Scandavini, Chiara, Serradilla-Martin, Mario, Stättner, Stefan, Tomazic, Ales, Varga, Martin, Zavrtanik, Hana, Zerbi, Alessandro, Erkan, Mert, Kleeff, Jörg, Lesurtel, Mickaël, Besselink, Marc G., and Ramia-Angel, Jose M.

Published
2020
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11. Supplementary Data from Multi-omic Characterization of Pancreatic Ductal Adenocarcinoma Relates CXCR4 mRNA Expression Levels to Potential Clinical Targets

Author

Kocher, Florian, primary, Puccini, Alberto, primary, Untergasser, Gerold, primary, Martowicz, Agnieszka, primary, Zimmer, Kai, primary, Pircher, Andreas, primary, Baca, Yasmine, primary, Xiu, Joanne, primary, Haybaeck, Johannes, primary, Tymoszuk, Piotr, primary, Goldberg, Richard M., primary, Petrillo, Angelica, primary, Shields, Anthony F., primary, Salem, Mohamed E., primary, Marshall, John L., primary, Hall, Michael, primary, Korn, W. Michael, primary, Nabhan, Chadi, primary, Battaglin, Francesca, primary, Lenz, Heinz-Josef, primary, Lou, Emil, primary, Choo, Su-Pin, primary, Toh, Chee-Keong, primary, Gasteiger, Silvia, primary, Pichler, Renate, primary, Wolf, Dominik, primary, and Seeber, Andreas, primary

Published
2023
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12. Supplementary Figure from Multi-omic Characterization of Pancreatic Ductal Adenocarcinoma Relates CXCR4 mRNA Expression Levels to Potential Clinical Targets

Author

Kocher, Florian, primary, Puccini, Alberto, primary, Untergasser, Gerold, primary, Martowicz, Agnieszka, primary, Zimmer, Kai, primary, Pircher, Andreas, primary, Baca, Yasmine, primary, Xiu, Joanne, primary, Haybaeck, Johannes, primary, Tymoszuk, Piotr, primary, Goldberg, Richard M., primary, Petrillo, Angelica, primary, Shields, Anthony F., primary, Salem, Mohamed E., primary, Marshall, John L., primary, Hall, Michael, primary, Korn, W. Michael, primary, Nabhan, Chadi, primary, Battaglin, Francesca, primary, Lenz, Heinz-Josef, primary, Lou, Emil, primary, Choo, Su-Pin, primary, Toh, Chee-Keong, primary, Gasteiger, Silvia, primary, Pichler, Renate, primary, Wolf, Dominik, primary, and Seeber, Andreas, primary

Published
2023
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13. Supplementary Table from Multi-omic Characterization of Pancreatic Ductal Adenocarcinoma Relates CXCR4 mRNA Expression Levels to Potential Clinical Targets

Author

Kocher, Florian, primary, Puccini, Alberto, primary, Untergasser, Gerold, primary, Martowicz, Agnieszka, primary, Zimmer, Kai, primary, Pircher, Andreas, primary, Baca, Yasmine, primary, Xiu, Joanne, primary, Haybaeck, Johannes, primary, Tymoszuk, Piotr, primary, Goldberg, Richard M., primary, Petrillo, Angelica, primary, Shields, Anthony F., primary, Salem, Mohamed E., primary, Marshall, John L., primary, Hall, Michael, primary, Korn, W. Michael, primary, Nabhan, Chadi, primary, Battaglin, Francesca, primary, Lenz, Heinz-Josef, primary, Lou, Emil, primary, Choo, Su-Pin, primary, Toh, Chee-Keong, primary, Gasteiger, Silvia, primary, Pichler, Renate, primary, Wolf, Dominik, primary, and Seeber, Andreas, primary

Published
2023
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14. Data from Multi-omic Characterization of Pancreatic Ductal Adenocarcinoma Relates CXCR4 mRNA Expression Levels to Potential Clinical Targets

Author

Kocher, Florian, primary, Puccini, Alberto, primary, Untergasser, Gerold, primary, Martowicz, Agnieszka, primary, Zimmer, Kai, primary, Pircher, Andreas, primary, Baca, Yasmine, primary, Xiu, Joanne, primary, Haybaeck, Johannes, primary, Tymoszuk, Piotr, primary, Goldberg, Richard M., primary, Petrillo, Angelica, primary, Shields, Anthony F., primary, Salem, Mohamed E., primary, Marshall, John L., primary, Hall, Michael, primary, Korn, W. Michael, primary, Nabhan, Chadi, primary, Battaglin, Francesca, primary, Lenz, Heinz-Josef, primary, Lou, Emil, primary, Choo, Su-Pin, primary, Toh, Chee-Keong, primary, Gasteiger, Silvia, primary, Pichler, Renate, primary, Wolf, Dominik, primary, and Seeber, Andreas, primary

Published
2023
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15. Multi-omic Characterization of Pancreatic Ductal Adenocarcinoma Relates CXCR4 mRNA Expression Levels to Potential Clinical Targets

Author

Kocher, Florian, primary, Puccini, Alberto, additional, Untergasser, Gerold, additional, Martowicz, Agnieszka, additional, Zimmer, Kai, additional, Pircher, Andreas, additional, Baca, Yasmine, additional, Xiu, Joanne, additional, Haybaeck, Johannes, additional, Tymoszuk, Piotr, additional, Goldberg, Richard M., additional, Petrillo, Angelica, additional, Shields, Anthony F., additional, Salem, Mohamed E., additional, Marshall, John L., additional, Hall, Michael, additional, Korn, W. Michael, additional, Nabhan, Chadi, additional, Battaglin, Francesca, additional, Lenz, Heinz-Josef, additional, Lou, Emil, additional, Choo, Su-Pin, additional, Toh, Chee-Keong, additional, Gasteiger, Silvia, additional, Pichler, Renate, additional, Wolf, Dominik, additional, and Seeber, Andreas, additional

Published
2022
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16. Management of asymptomatic sporadic non-functioning pancreatic neuroendocrine neoplasms no larger than 2 cm: interim analysis of prospective ASPEN trial

Author

Partelli, Stefano, primary, Massironi, Sara, additional, Zerbi, Alessandro, additional, Niccoli, Patricia, additional, Kwon, Wooil, additional, Landoni, Luca, additional, Panzuto, Francesco, additional, Tomazic, Ales, additional, Bongiovanni, Alberto, additional, Kaltsas, Gregory, additional, Sauvanet, Alain, additional, Bertani, Emilio, additional, Mazzaferro, Vincenzo, additional, Caplin, Martyn, additional, Armstrong, Thomas, additional, Weickert, Martin O, additional, Ramage, John, additional, Segelov, Eva, additional, Butturini, Giovanni, additional, Staettner, Stefan, additional, Cives, Mauro, additional, Frilling, Andrea, additional, Moulton, Carol Anne, additional, He, Jin, additional, Boesch, Florian, additional, Selberheer, Andreas, additional, Twito, Orit, additional, Castaldi, Antonio, additional, De Angelis, Claudio G, additional, Gaujoux, Sebastien, additional, Holzer, Katharina, additional, Wilson, Colin H, additional, Almeamar, Hussein, additional, Vigia, Emanuel, additional, Muffatti, Francesca, additional, Lucà, Martina, additional, Lania, Andrea, additional, Ewald, Jacques, additional, Kim, Hongbeom, additional, Salvia, Roberto, additional, Rinzivillo, Maria, additional, Smid, Alojz, additional, Gardini, Andrea, additional, Tsoli, Marina, additional, Hentic, Olivia, additional, Colombo, Samuele, additional, Citterio, Davide, additional, Toumpanakis, Christos, additional, Ramsey, Emma, additional, Randeva, Harpal S, additional, Srirajaskanthan, Ray, additional, Croagh, Daniel, additional, Regi, Paolo, additional, Gasteiger, Silvia, additional, Invernizzi, Pietro, additional, Ridolfi, Cristina, additional, Giovannini, Marc, additional, Jang, Jin-Young, additional, Bassi, Claudio, additional, and Falconi, Massimo, additional

Published
2022
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17. Clinical Outcomes After Total Pancreatectomy A Prospective Multicenter Pan-European Snapshot Study

Author

Latenstein, Anouk E. J., Scholten, Lianne, Al-Saffar, Hasan Ahmad, Björnsson, Bergthor, Butturini, Giovanni, Capretti, Giovanni, Chatzizacharias, Nikolaos A., Dervenis, Chris, Frigerio, Isabella, Gallagher, Tom K., Gasteiger, Silvia, Halimi, Asif, Labori, Knut J., Montagnini, Greta, Munoz-Bellvis, Luis, Nappo, Gennaro, Nikov, Andrej, Pando, Elizabeth, de Pastena, Matteo, De La Pena-Moral, Jesus M., Radenkovic, Dejan, Roberts, Keith J., Salvia, Roberto, Sanchez-Bueno, Francisco, Scandavini, Chiara, Serradilla-Martin, Mario, Stattner, Stefan, Tomazic, Ales, Varga, Martin, Zavrtanik, Hana, Zerbi, Alessandro, Erkan, Mert, Kleeff, Jorg, Lesurtel, Mickael, Besselink, Marc G., Ramia-Angel, Jose M., Latenstein, Anouk E. J., Scholten, Lianne, Al-Saffar, Hasan Ahmad, Björnsson, Bergthor, Butturini, Giovanni, Capretti, Giovanni, Chatzizacharias, Nikolaos A., Dervenis, Chris, Frigerio, Isabella, Gallagher, Tom K., Gasteiger, Silvia, Halimi, Asif, Labori, Knut J., Montagnini, Greta, Munoz-Bellvis, Luis, Nappo, Gennaro, Nikov, Andrej, Pando, Elizabeth, de Pastena, Matteo, De La Pena-Moral, Jesus M., Radenkovic, Dejan, Roberts, Keith J., Salvia, Roberto, Sanchez-Bueno, Francisco, Scandavini, Chiara, Serradilla-Martin, Mario, Stattner, Stefan, Tomazic, Ales, Varga, Martin, Zavrtanik, Hana, Zerbi, Alessandro, Erkan, Mert, Kleeff, Jorg, Lesurtel, Mickael, Besselink, Marc G., and Ramia-Angel, Jose M.

Abstract

Objective: To assess outcomes among patients undergoing total pancreatectomy (TP) including predictors for complications and in-hospital mortality. Background: Current studies on TP mostly originate from high-volume centers and span long time periods and therefore may not reflect daily practice. Methods: This prospective pan-European snapshot study included patients who underwent elective (primary or completion) TP in 43 centers in 16 European countries (June 2018-June 2019). Subgroup analysis included cutoff values for annual volume of pancreatoduodenectomies (<60 vs >= 60). Predictors for major complications and in-hospital mortality were assessed in multivariable logistic regression. Results: In total, 277 patients underwent TP, mostly for malignant disease (73%). Major postoperative complications occurred in 70 patients (25%). Median hospital stay was 12 days (IQR 9-18) and 40 patients were readmitted (15%). In-hospital mortality was 5% and 90-day mortality 8%. In the subgroup analysis, in-hospital mortality was lower in patients operated in centers with >= 60 pancreatoduodenectomies compared <60 (4% vs 10%, P = 0.046). In multivariable analysis, annual volume <60 pancreatoduodenectomies (OR 3.78, 95% CI 1.18-12.16, P = 0.026), age (OR 1.07, 95% CI 1.01-1.14, P = 0.046), and estimated blood loss >= 2L (OR 11.89, 95% CI 2.64-53.61, P = 0.001) were associated with in-hospital mortality. ASA >= 3 (OR 2.87, 95% CI 1.56-5.26, P = 0.001) and estimated blood loss >= 2L (OR 3.52, 95% CI 1.25-9.90, P = 0.017) were associated with major complications. Conclusion: This pan-European prospective snapshot study found a 5% inhospital mortality after TP. The identified predictors for mortality, including low-volume centers, age, and increased blood loss, may be used to improve outcomes.

Published
2022
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18. Perfusate Enzymes and Platelets Indicate Early Allograft Dysfunction After Transplantation of Normothermically Preserved Livers

Author

Weissenbacher, Annemarie, primary, Bogensperger, Christina, additional, Oberhuber, Rupert, additional, Meszaros, Andras, additional, Gasteiger, Silvia, additional, Ulmer, Hanno, additional, Berchtold, Valeria, additional, Krendl, Felix J., additional, Fodor, Margot, additional, Messner, Franka, additional, Hautz, Theresa, additional, Otarashvili, Giorgi, additional, Resch, Thomas, additional, Margreiter, Christian, additional, Maglione, Manuel, additional, Irsara, Christian, additional, Griesmacher, Andrea, additional, Raynaud, Marc, additional, Breitkopf, Robert, additional, Troppmair, Jakob, additional, Öfner, Dietmar, additional, Cardini, Benno, additional, and Schneeberger, Stefan, additional

Published
2022
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21. Management of Asymptomatic Sporadic Nonfunctioning Pancreatic Neuroendocrine Neoplasms (ASPEN) ≤2 cm: Study Protocol for a Prospective Observational Study

Author

Partelli, Stefano, primary, Ramage, John K., additional, Massironi, Sara, additional, Zerbi, Alessandro, additional, Kim, Hong Beom, additional, Niccoli, Patricia, additional, Panzuto, Francesco, additional, Landoni, Luca, additional, Tomazic, Ales, additional, Ibrahim, Toni, additional, Kaltsas, Gregory, additional, Bertani, Emilio, additional, Sauvanet, Alain, additional, Segelov, Eva, additional, Caplin, Martyn, additional, Coppa, Jorgelina, additional, Armstrong, Thomas, additional, Weickert, Martin O., additional, Butturini, Giovanni, additional, Staettner, Stefan, additional, Boesch, Florian, additional, Cives, Mauro, additional, Moulton, Carol Anne, additional, He, Jin, additional, Selberherr, Andreas, additional, Twito, Orit, additional, Castaldi, Antonio, additional, De Angelis, Claudio Giovanni, additional, Gaujoux, Sebastien, additional, Almeamar, Hussein, additional, Frilling, Andrea, additional, Vigia, Emanuel, additional, Wilson, Colin, additional, Muffatti, Francesca, additional, Srirajaskanthan, Raj, additional, Invernizzi, Pietro, additional, Lania, Andrea, additional, Kwon, Wooil, additional, Ewald, Jacques, additional, Rinzivillo, Maria, additional, Nessi, Chiara, additional, Smid, Lojze M., additional, Gardini, Andrea, additional, Tsoli, Marina, additional, Picardi, Edgardo E., additional, Hentic, Olivia, additional, Croagh, Daniel, additional, Toumpanakis, Christos, additional, Citterio, Davide, additional, Ramsey, Emma, additional, Mosterman, Barbara, additional, Regi, Paolo, additional, Gasteiger, Silvia, additional, Rossi, Roberta E., additional, Smiroldo, Valeria, additional, Jang, Jin-Young, additional, and Falconi, Massimo, additional

Published
2020
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22. Sex differences in disease presentation, surgical and oncological outcome of liver resection for primary and metastatic liver tumors—A retrospective multicenter study

Author

Braunwarth, Eva, primary, Rumpf, Benedikt, additional, Primavesi, Florian, additional, Pereyra, David, additional, Hochleitner, Margarethe, additional, Göbel, Georg, additional, Gasteiger, Silvia, additional, Gehwolf, Philipp, additional, Öfner, Dietmar, additional, Starlinger, Patrick, additional, and Stättner, Stefan, additional

Published
2020
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24. A Retrospective Propensity Score Matched Analysis Reveals Superiority of Hypothermic Machine Perfusion over Static Cold Storage in Deceased Donor Kidney Transplantation

Author

Gasteiger, Silvia, primary, Berchtold, Valeria, additional, Bösmüller, Claudia, additional, Dostal, Lucie, additional, Ulmer, Hanno, additional, Bogensperger, Christina, additional, Resch, Thomas, additional, Rudnicki, Michael, additional, Neuwirt, Hannes, additional, Oberhuber, Rupert, additional, Cardini, Benno, additional, Scheidl, Stefan, additional, Mayer, Gert, additional, Öfner, Dietmar, additional, Weissenbacher, Annemarie, additional, and Schneeberger, Stefan, additional

Published
2020
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25. Clinical Outcomes after Total Pancreatectomy: A Prospective Multicenter Pan-European Snapshot Study.

Author

UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - (MGD) Service de chirurgie, Latenstein, Anouk E J, Scholten, Lianne, Al-Saffar, Hasan Ahmad, Björnsson, Bergthor, Butturini, Giovanni, Capretti, Giovanni, Chatzizacharias, Nikolaos A, Dervenis, Chris, Frigerio, Isabella, Gallagher, Tom K, Gasteiger, Silvia, Halimi, Asif, Labori, Knut J, Montagnini, Greta, Muñoz-Bellvis, Luis, Nappo, Gennaro, Nikov, Andrej, Pando, Elizabeth, de Pastena, Matteo, de la Peña-Moral, Jesús M, Radenkovic, Dejan, Roberts, Keith J, Salvia, Roberto, Sanchez-Bueno, Francisco, Scandavini, Chiara, Serradilla-Martin, Mario, Stättner, Stefan, Tomazic, Ales, Varga, Martin, Zavrtanik, Hana, Zerbi, Alessandro, Erkan, Mert, Kleeff, Jörg, Lesurtel, Mickaël, Besselink, Marc G, Ramia-Angel, Jose M, Scientific, Research Committee of the European-African Hepato-Pancreato-Biliary Association (E-AHPBA), Bertrand, Claude, UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - (MGD) Service de chirurgie, Latenstein, Anouk E J, Scholten, Lianne, Al-Saffar, Hasan Ahmad, Björnsson, Bergthor, Butturini, Giovanni, Capretti, Giovanni, Chatzizacharias, Nikolaos A, Dervenis, Chris, Frigerio, Isabella, Gallagher, Tom K, Gasteiger, Silvia, Halimi, Asif, Labori, Knut J, Montagnini, Greta, Muñoz-Bellvis, Luis, Nappo, Gennaro, Nikov, Andrej, Pando, Elizabeth, de Pastena, Matteo, de la Peña-Moral, Jesús M, Radenkovic, Dejan, Roberts, Keith J, Salvia, Roberto, Sanchez-Bueno, Francisco, Scandavini, Chiara, Serradilla-Martin, Mario, Stättner, Stefan, Tomazic, Ales, Varga, Martin, Zavrtanik, Hana, Zerbi, Alessandro, Erkan, Mert, Kleeff, Jörg, Lesurtel, Mickaël, Besselink, Marc G, Ramia-Angel, Jose M, Scientific, Research Committee of the European-African Hepato-Pancreato-Biliary Association (E-AHPBA), and Bertrand, Claude

Abstract

To assess outcomes among patients undergoing total pancreatectomy (TP) including predictors for complications and in-hospital mortality. Current studies on TP mostly originate from high-volume centers and span long time periods and therefore may not reflect daily practice. This prospective pan-European snapshot study included patients who underwent elective (primary or completion) TP in 43 centers in 16 European countries (June 2018-June 2019). Subgroup analysis included cut-off values for annual volume of pancreatoduodenectomies (<60 vs. ≥60). Predictors for major complications and in-hospital mortality were assessed in multivariable logistic regression. In total, 277 patients underwent TP, mostly for malignant disease (73%). Major postoperative complications occurred in 70 patients (25%). Median hospital stay was 12 days (IQR 9-18) and 40 patients were readmitted (15%). In-hospital mortality was 5% and 90-day mortality 8%. In the subgroup analysis, in-hospital mortality was lower in patients operated in centers with ≥60 pancreatoduodenectomies compared < 60 (4% vs. 10%, p = 0.046). In multivariable analysis, annual volume < 60 pancreatoduodenectomies (OR 3.78, 95%CI 1.18-12.16, p = 0.026), age (OR 1.07, 95%CI 1.01-1.14, p = 0.046), and estimated blood loss ≥2L (OR 11.89, 95%CI 2.64-53.61, p = 0.001) were associated with in-hospital mortality. ASA ≥3 (OR 2.87, 95%CI 1.56-5.26, p = 0.001) and estimated blood loss ≥2L (OR 3.52, 95%CI 1.25-9.90, p = 0.017) were associated with major complications. This pan-European prospective snapshot study found a 5% in-hospital after TP. The identified predictors for mortality, including low-volume centers, age, and increased blood loss, may be used to improve outcomes.

Published
2020

26. OMIP 077: Definition of all principal human leukocyte populations using a broadly applicable 14‐color panel.

Author

Boesch, Maximilian, Sykora, Martina, Gasteiger, Silvia, Baty, Florent, Brutsche, Martin H., and Sopper, Sieghart

Abstract

This Optimized Multicolor Immunofluorescence Panel was designed to identify and quantify all principal leukocyte populations in human blood using a minimum number of markers. We achieved this goal using a carefully selected combination of 14 surface markers compatible with standard flow cytometric instruments and accessible to a particularly large research community. Optimized for use in whole blood, this panel allows polymorphonuclear cell identification, supports live cell recovery, and is well‐suited for absolute cell counting applications in the original in vivo volume. Panel performance and the separation of populations are high, and virtually no cells remain undefined after gating. Besides the identification of neutrophils, eosinophils, basophils, T cells, natural killer cells, B cells, plasma cells, monocytes, myeloid dendritic cells and plasmacytoid dendritic cells, this panel also covers progenitor cells and may therefore be attractive for stem cell researchers. Envisioned applications of this panel include immune monitoring within clinical trials, initial discovery to inform subset‐targeted panels, and clinical diagnostics. In summary, this panel offers a broadly applicable platform for immune cell identification, quantification and characterization in human samples, particularly whole blood. [ABSTRACT FROM AUTHOR]

Published
2022
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28. Management of asymptomatic sporadic non-functioning pancreatic neuroendocrine neoplasms no larger than 2 cm: interim analysis of prospective ASPEN trial

Author

Stefano Partelli, Sara Massironi, Alessandro Zerbi, Patricia Niccoli, Wooil Kwon, Luca Landoni, Francesco Panzuto, Ales Tomazic, Alberto Bongiovanni, Gregory Kaltsas, Alain Sauvanet, Emilio Bertani, Vincenzo Mazzaferro, Martyn Caplin, Thomas Armstrong, Martin O Weickert, John Ramage, Eva Segelov, Giovanni Butturini, Stefan Staettner, Mauro Cives, Andrea Frilling, Carol Anne Moulton, Jin He, Florian Boesch, Andreas Selberheer, Orit Twito, Antonio Castaldi, Claudio G De Angelis, Sebastien Gaujoux, Katharina Holzer, Colin H Wilson, Hussein Almeamar, Emanuel Vigia, Francesca Muffatti, Martina Lucà, Andrea Lania, Jacques Ewald, Hongbeom Kim, Roberto Salvia, Maria Rinzivillo, Alojz Smid, Andrea Gardini, Marina Tsoli, Olivia Hentic, Samuele Colombo, Davide Citterio, Christos Toumpanakis, Emma Ramsey, Harpal S Randeva, Ray Srirajaskanthan, Daniel Croagh, Paolo Regi, Silvia Gasteiger, Pietro Invernizzi, Cristina Ridolfi, Marc Giovannini, Jin-Young Jang, Claudio Bassi, Massimo Falconi, Partelli, Stefano, Massironi, Sara, Zerbi, Alessandro, Niccoli, Patricia, Kwon, Wooil, Landoni, Luca, Panzuto, Francesco, Tomazic, Ale, Bongiovanni, Alberto, Kaltsas, Gregory, Sauvanet, Alain, Bertani, Emilio, Mazzaferro, Vincenzo, Caplin, Martyn, Armstrong, Thoma, Weickert, Martin O, Ramage, John, Segelov, Eva, Butturini, Giovanni, Staettner, Stefan, Cives, Mauro, Frilling, Andrea, Moulton, Carol Anne, He, Jin, Boesch, Florian, Selberheer, Andrea, Twito, Orit, Castaldi, Antonio, De Angelis, Claudio G, Gaujoux, Sebastien, Holzer, Katharina, Wilson, Colin H, Almeamar, Hussein, Vigia, Emanuel, Muffatti, Francesca, Lucà, Martina, Lania, Andrea, Ewald, Jacque, Kim, Hongbeom, Salvia, Roberto, Rinzivillo, Maria, Smid, Alojz, Gardini, Andrea, Tsoli, Marina, Hentic, Olivia, Colombo, Samuele, Citterio, Davide, Toumpanakis, Christo, Ramsey, Emma, Randeva, Harpal S, Srirajaskanthan, Ray, Croagh, Daniel, Regi, Paolo, Gasteiger, Silvia, Invernizzi, Pietro, Ridolfi, Cristina, Giovannini, Marc, Jang, Jin Young, Bassi, Claudio, and Falconi, Massimo

Subjects
asymptomatic pancreatic neuroendocrine neoplasms, Pancreatic surgery, asymptomatic pancreatic neuroendocrine neoplasms, Pancreatic neoplasm, Pancreatic surgery, pancreatic endocrine tumors, surgery, management, prognosis, Pancreatic Neoplasms, Settore MED/18 - Chirurgia Generale, Neuroendocrine Tumors, Pancreatectomy, Humans, Surgery, Prospective Studies, Pancreatic neoplasm
Published
2022

29. Management of Asymptomatic Sporadic Nonfunctioning Pancreatic Neuroendocrine Neoplasms (ASPEN) ≤2 cm: Study Protocol for a Prospective Observational Study

Author

Stefano Partelli, John K. Ramage, Sara Massironi, Alessandro Zerbi, Hong Beom Kim, Patricia Niccoli, Francesco Panzuto, Luca Landoni, Ales Tomazic, Toni Ibrahim, Gregory Kaltsas, Emilio Bertani, Alain Sauvanet, Eva Segelov, Martyn Caplin, Jorgelina Coppa, Thomas Armstrong, Martin O. Weickert, Giovanni Butturini, Stefan Staettner, Florian Boesch, Mauro Cives, Carol Anne Moulton, Jin He, Andreas Selberherr, Orit Twito, Antonio Castaldi, Claudio Giovanni De Angelis, Sebastien Gaujoux, Hussein Almeamar, Andrea Frilling, Emanuel Vigia, Colin Wilson, Francesca Muffatti, Raj Srirajaskanthan, Pietro Invernizzi, Andrea Lania, Wooil Kwon, Jacques Ewald, Maria Rinzivillo, Chiara Nessi, Lojze M. Smid, Andrea Gardini, Marina Tsoli, Edgardo E. Picardi, Olivia Hentic, Daniel Croagh, Christos Toumpanakis, Davide Citterio, Emma Ramsey, Barbara Mosterman, Paolo Regi, Silvia Gasteiger, Roberta E. Rossi, Valeria Smiroldo, Jin-Young Jang, Massimo Falconi, Partelli, S, Ramage, J, Massironi, S, Zerbi, A, Kim, H, Niccoli, P, Panzuto, F, Landoni, L, Tomazic, A, Ibrahim, T, Kaltsas, G, Bertani, E, Sauvanet, A, Segelov, E, Caplin, M, Coppa, J, Armstrong, T, Weickert, M, Butturini, G, Staettner, S, Boesch, F, Cives, M, Moulton, C, He, J, Selberherr, A, Twito, O, Castaldi, A, De Angelis, C, Gaujoux, S, Almeamar, H, Frilling, A, Vigia, E, Wilson, C, Muffatti, F, Srirajaskanthan, R, Invernizzi, P, Lania, A, Kwon, W, Ewald, J, Rinzivillo, M, Nessi, C, Smid, L, Gardini, A, Tsoli, M, Picardi, E, Hentic, O, Croagh, D, Toumpanakis, C, Citterio, D, Ramsey, E, Mosterman, B, Regi, P, Gasteiger, S, Rossi, R, Smiroldo, V, Jang, J, Falconi, M, Partelli, Stefano, Ramage, John K, Massironi, Sara, Zerbi, Alessandro, Kim, Hong Beom, Niccoli, Patricia, Panzuto, Francesco, Landoni, Luca, Tomazic, Ale, Ibrahim, Toni, Kaltsas, Gregory, Bertani, Emilio, Sauvanet, Alain, Segelov, Eva, Caplin, Martyn, Coppa, Jorgelina, Armstrong, Thoma, Weickert, Martin O, Butturini, Giovanni, Staettner, Stefan, Boesch, Florian, Cives, Mauro, Moulton, Carol Anne, He, Jin, Selberherr, Andrea, Twito, Orit, Castaldi, Antonio, De Angelis, Claudio Giovanni, Gaujoux, Sebastien, Almeamar, Hussein, Frilling, Andrea, Vigia, Emanuel, Wilson, Colin, Muffatti, Francesca, Srirajaskanthan, Raj, Invernizzi, Pietro, Lania, Andrea, Kwon, Wooil, Ewald, Jacque, Rinzivillo, Maria, Nessi, Chiara, Smid, Lojze M, Gardini, Andrea, Tsoli, Marina, Picardi, Edgardo E, Hentic, Olivia, Croagh, Daniel, Toumpanakis, Christo, Citterio, Davide, Ramsey, Emma, Mosterman, Barbara, Regi, Paolo, Gasteiger, Silvia, Rossi, Roberta E, Smiroldo, Valeria, Jang, Jin-Young, and Falconi, Massimo

Subjects
lcsh:R5-920, medicine.medical_specialty, Surgical approach, business.industry, Optimal treatment, Nodule (medicine), General Medicine, small nonfunctioning pancreatic neuroendocrine neoplasm, Asymptomatic, NF-PanNEN_2 cm, HCC CHBPT, ASPEN study, surgery, Study Protocol, aspen study, follow-up, management, nf-pannen_2 cm, surveillance, medicine, Medicine, Observational study, Radiology, medicine.symptom, lcsh:Medicine (General), business
Abstract

Introduction: The optimal treatment for small, asymptomatic, nonfunctioning pancreatic neuroendocrine neoplasms (NF-PanNEN) is still controversial. European Neuroendocrine Tumor Society (ENETS) guidelines recommend a watchful strategy for asymptomatic NF-PanNEN Methods: ASPEN is a prospective international observational multicentric cohort study supported by ENETS. The study is registered in ClinicalTrials.gov with the identification code NCT03084770. Based on the incidence of NF-PanNEN the number of expected patients to be enrolled in the ASPEN study is 1,000 during the study period (2017–2022). Primary endpoint is disease/progression-free survival, defined as the time from study enrolment to the first evidence of progression (active surveillance group) or recurrence of disease (surgery group) or death from disease. Inclusion criteria are: age >18 years, the presence of asymptomatic sporadic NF-PanNEN ≤2 cm proven by a positive fine-needle aspiration (FNA) or by the presence of a measurable nodule on high-quality imaging techniques that is positive at 68Gallium DOTATOC-PET scan.Conclusion: The ASPEN study is designed to investigate if an active surveillance of asymptomatic NF-PanNEN ≤2 cm is safe as compared to surgical approach.

Published
2020

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