1. Gastrointestinal manifestations on impaired quality of life in systemic sclerosis.
- Author
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Yang H, Xu D, Li MT, Yao Y, Jin M, Zeng XF, and Qian JM
- Subjects
- Adult, Autoantibodies blood, Case-Control Studies, DNA Topoisomerases, Type I, Diarrhea etiology, Diarrhea rehabilitation, Dyspepsia etiology, Dyspepsia rehabilitation, Female, Gastroesophageal Reflux etiology, Gastroesophageal Reflux rehabilitation, Humans, Male, Middle Aged, Nuclear Proteins immunology, Psychometrics, Ribonucleoproteins immunology, Risk Factors, Scleroderma, Systemic rehabilitation, Severity of Illness Index, Surveys and Questionnaires, Gastrointestinal Diseases etiology, Gastrointestinal Diseases rehabilitation, Quality of Life, Scleroderma, Systemic complications
- Abstract
Objective: To analyze the impact of gastrointestinal manifestations on quality of life in patients with systemic sclerosis (SSc) and to provide clinical evidence for their early treatment and health-related management., Methods: Altogether 65 patients admitted to the Peking Union Medical College Hospital selected from a disease cohort and 127 matched controls were enrolled. A self-assessment questionnaire was completed by all participants. Each participant completed scleroderma gastrointestinal tract 1.0 (SSC-GIT 1.0) questionnaire (including reflux or indigestion, diarrhea, constipation, distention, emotional well-being, and social functioning). Autoimmune antibodies were tested in SSc patients., Results: Among these SSc cases, gastrointestinal manifestations were seen in 84.6%. Reflux/indigestion and diarrhea were more common in SSc patients than in the control group (67.7% vs 27.8%; 27.7% vs 10.2%, P < 0.05). SSc patients had a significantly higher percentage of abnormal social functioning than the control group (33.8% vs 3.9%, P < 0.05). SSc patients with abnormal social functioning and abnormal emotional well-being had worse distention, diarrhea, and constipation statuses. Patients with reflux or indigestion and diarrhea had lower anti-Scl-70 level than those without (both P < 0.05). Patients with distention had higher levels of anti-RNP and anti-SSA than those without distention (both P < 0.05). Patients with diarrhea had higher levels of anti-RNP than those without diarrhea (P = 0.014)., Conclusions: Gastrointestinal involvement is frequent in SSc, with reflux or indigestion as the most common symptom. The impaired quality of life in patients with SSc indicates that early and active management should be considered., (© 2019 Chinese Medical Association Shanghai Branch, Chinese Society of Gastroenterology, Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine and John Wiley & Sons Australia, Ltd.) more...
- Published
- 2019
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