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©2010 The American Physical Society. Travel between Bayreuth and Madrid was supported by the joint program Acciones Integradas of Deutscher Akademscher Auslandsdienst (DAAD) and Ministerio de Educación y Ciencia (MEC). C.G. and C.A.M acknowledge financial support from Deutsche Forschungsgemeinschaft (DFG), and thank H.-C. Nägerl and his group for hospitality and helpful discussions. Work at Madrid was supported by MEC (Project MOSAICO). Work at Maceio was partially supported by the Brazilian research agencies Conselho Nacional de Desenvolvimento Científico e Tecnologico (CNPq) and Coordenac ión de Aperfecionamiento de Pessoal de Nível Superior (CAPES)., Bloch oscillations of Bose-Einstein condensates realize sensitive matter-wave interferometers. We investigate the dynamics and stability of bright-soliton wave packets in one-dimensional tilted optical lattices with a modulated mean-field interaction g(t). By means of a time-reversal argument, we prove the stability of Bloch oscillations of breathing solitons that would be quasistatically unstable. Floquet theory shows that these breathing solitons can be more stable against certain experimental perturbations than rigid solitons or even noninteracting wave packets., Deutscher Akademischer Auslandsdienst (DAAD), Ministerio de Educacion y Ciencia (MEC), Deutsche Forschungsgemeinschaft (DFG), MEC, Brazilian research agencies Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq), Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES), Depto. de Física de Materiales, Fac. de Ciencias Físicas, TRUE, pub

PURPOSE: Despite the rapid uptake of multigene panel testing (MGPT) for hereditary cancer predisposition, there is limited guidance surrounding indications for testing and genes to include. METHODS: To inform the clinical approach to hereditary cancer MGPT, we comprehensively evaluated 32 cancer predisposition genes by assessing phenotype-specific pathogenic variant (PV) frequencies, cancer risk associations, and performance of genetic testing criteria in a cohort of 165,000 patients referred for MGPT. RESULTS: We identified extensive genetic heterogeneity surrounding predisposition to cancer types commonly referred for germline testing (breast, ovarian, colorectal, uterine/endometrial, pancreatic, and melanoma). PV frequencies were highest among patients with ovarian cancer (13.8%) and lowest among patients with melanoma (8.1%). Fewer than half of PVs identified in patients meeting testing criteria for only BRCA1/2 or only Lynch syndrome occurred in the respective genes (33.1% and 46.2%). In addition, 5.8% of patients with PVs in BRCA1/2 and 26.9% of patients with PVs in Lynch syndrome genes did not meet respective testing criteria. CONCLUSION: Opportunities to improve upon identification of patients at risk for hereditary cancer predisposition include revising BRCA1/2 and Lynch syndrome testing criteria to include additional clinically actionable genes with overlapping phenotypes and relaxing testing criteria for associated cancers.