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Background: Understanding the clinical features of myocarditis in various age groups is required to identify age-specific disease patterns., Objectives: The objective of this study was to examine differences in sex distribution and clinical outcomes in patients with myocarditis of various ages., Methods: Patients with acute or chronic myocarditis in 3 centers in Berlin, Germany from 2005 to 2021 and in the United States (National Inpatient Sample) from 2010 to 2019 were included. Age groups examined included "prepubescent" (below 11 years for females and below 13 years for males), adolescents (11 [female] or 13 [male] to 18 years), young adults (18-35 years), "middle-aged adults" (35-54 years), and older adults (age >54 years). In patients admitted to the hospital, hospital mortality, length of stay, and medical complication rates were examined., Results: Overall, 6,023 cases in Berlin and 9,079 cases in the U.S. cohort were included. In both cohorts, there were differences in sex distribution among the 5 age categories, and differences in the distribution were most notable in adolescents (69.3% males vs 30.7% females) and in young adults (73.8% males vs 26.3% females). Prepubescent and older adults had the highest rates of in-hospital mortality, hospital length of stay, and medical complications. In the Berlin cohort, prepubescent patients had higher levels of leukocytes ( P < 0.001), antistreptolysin antibody ( P < 0.001), and NT-proBNP ( P < 0.001) when compared to young adults., Conclusions: In this study, we found that sex differences in myocarditis and clinical features of myocarditis were age-dependent.

Aim: Understanding the public health burden of cardiac arrest (CA) is important to inform healthcare policies, particularly during healthcare crises such as the COVID-19 pandemic. This study aimed to analyse outcomes of in-hospital mortality and healthcare resource utilisation in adult patients with CA in the United States over the last decade prior to the COVID-19 pandemic., Methods: The United States (US) National Inpatient Sample was utilised to identify hospitalised adult patients with CA between 2010 and 2019. Logistic and Poisson regression models were used to analyse outcomes by adjusting for 47 confounders., Results: 248,754 adult patients with CA (without "Do Not Resuscitate"-orders) were included in this study, out of which 57.5% were male. In-hospital mortality was high with 51.2% but improved significantly from 58.3% in 2010 to 46.4% in 2019 (P < 0.001). Particularly, elderly patients, non-white patients and patients requiring complex therapy had a higher mortality rate. Although the average hospital LOS decreased by 11%, hospital expenses have increased by 13% between 2010 and 2019 (each P < 0.001), presumably due to more frequent use of mechanical circulatory support (MCS, e.g. ECMO from 2.6% to 8.7% or Impella® micro-axial flow pump from 1.8% to 14.2%). Strong disparities existed among patient age groups and ethnicities across the US. Of note, the number of young adults with CA and opioid-induced CA has almost doubled within the study period., Conclusion: Over the last ten years prior to the COVID-19 pandemic, CA-related survival has incrementally improved with shorter hospitalisations and increased medical expenses, while strong disparities existed among different age groups and ethnicities. National standards for CA surveillance should be considered to identify trends and differences in CA treatment to allow for standardised medical care., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 The Author(s). Published by Elsevier B.V. All rights reserved.)

Percutaneous left atrial appendage closure (LAAC) has emerged as a non-pharmacological alternative for stroke prevention in patients with atrial fibrillation (AF) not suitable for anticoagulation therapy. Real-world data on peri-procedural outcomes are limited. The aim of this study was to analyze outcomes of peri-procedural safety and healthcare resource utilization in 11,240 adult patients undergoing LAAC in the United States between 2016 and 2019. Primary outcomes (safety) were in-hospital ischemic stroke or systemic embolism (SE), pericardial effusion (PE), major bleeding, device embolization and mortality. Secondary outcomes (resource utilization) were adverse discharge disposition, hospital length of stay (LOS) and costs. Logistic and Poisson regression models were used to analyze outcomes by adjusting for 10 confounders. SE decreased by 97% between 2016 and 2019 [95% Confidence Interval (CI) 0-0.24] ( p = 0.003), while a trend to lower numbers of other peri-procedural complications was determined. In-hospital mortality (0.14%) remained stable. Hospital LOS decreased by 17% (0.78-0.87, p < 0.001) and adverse discharge rate by 41% (95% CI 0.41-0.86, p = 0.005) between 2016 and 2019, while hospital costs did not significantly change ( p = 0.2). Female patients had a higher risk of PE (OR 2.86 [95% CI 2.41-6.39]) and SE (OR 5.0 [95% CI 1.28-43.6]) while multi-morbid patients had higher risks of major bleeding ( p < 0.001) and mortality ( p = 0.031), longer hospital LOS ( p < 0.001) and increased treatment costs ( p = 0.073). Significant differences in all outcomes were observed between male and female patients across US regions. In conclusion, LAAC has become a safer and more efficient procedure. Significant sex differences existed across US regions. Careful considerations should be taken when performing LAAC in female and comorbid patients.

The endothelial glycocalyx maintains vascular structure and may be subject to shedding during inflammation and also during high-intensive exercise. There are no studies on shedding during ultra-endurance exercise. The "Yukon Arctic Ultra" (YAU) is one of the longest and coldest ultramarathons and its impact on glycocalyx shedding was investigated. Thirteen adults (38.92 ± 8.67 yr, 6 females) of YAU editions 2015-2019 completed 657.03 ± 71.65 km at a moving velocity of 4.17 ± 0.62 km/h. Mean daily temperatures ranged from -12.6°C to -30.5°C. Glycocalyx elements heparan sulfate, hyaluronan, and syndecan CD-138 were quantified from serum at start, 277 km, 383 km, and 690 km. Cortisol, C-reactive protein, creatine kinase, and N-terminal-prohormone of brain natriuretic peptide were also quantified. Seven YAU volunteers (36.14 ± 11.04 yr, 5 females) served as control. There were no time-changes among the control. Among finishers, there was a significant increase for hyaluronan and a significant decrease for syndecan CD-138. Values were greater among female finishers for heparan sulfate at start, 383 km, and 690 km, and among male finishers for hyaluronan at 277 km. Values for syndecan CD-138 were greater among older finishers at all timepoints. There were weak significant correlations ( R 2 < 0.215) between hyaluronan and distance, creatine kinase, and NT-Pro BNP, respectively. Shedding of glycocalyx elements is shown among participants of the YAU. Greater shedding of heparan sulfate among female, greater increases of hyaluronan among male, and greater shedding of syndecan CD-138 among older athletes indicate complex glycocalyx shedding during ultra-endurance exercise. NEW & NOTEWORTHY This is the first study to investigate changes in glycocalyx elements in an endurance footrace and first study to investigate exercise-induced shedding in both sexes. This study comprised of an athlete group who finished the ultra-long distance of up to 690 km during the Yukon Arctic Ultra as well as a control group. Results indicate relevant and different shedding of glycocalyx elements heparan sulfate, hyaluronan, and syndecan CD-138. Sex, age, BMI, and covered distance appear to have an influence on the shedding. Other serum parameters indicative of stress appear to be associated with shedding.

A common dilemma is whether to ensure a safe environment for the older person or to allow the older person to continue to live independently in an environment where personal safety may not be ensured. Conflicting opinions between marginally competent older adults and adult children regarding satisfactory living arrangements involve a forced choice between the moral principles of beneficence and autonomy. An ethical dilemma cannot be resolved on the basis of values alone. Pertinent ethical principles must be applied and an ethical theory used to guide the resolution. Autonomy is considered the supreme ethical principle in Western culture. The decision to set it aside, even to promote safety, takes rigorous ethical justification.

The request of a ventilator-dependent quadriplegic person to be removed from the ventilator presents the health care team with an ethical dilemma. Application of ethical principles to case facts guides the decision maker. The ethical principle of autonomy requires that persons be respected and free to determine their course in life. The ethical principle of beneficence requires the health care team to actively benefit or do good for the patient. The ethical principle of nonmaleficence requires the health care team to refrain from harming a patient. The ethical duty of fidelity requires the nurse to be faithful to commitments made to patients. Ethical principles and duties are clear and straightforward. The decision of how they apply to a given case is not. However, applying them to a case, while not providing definitive answers, will provide the certainty that the decision was the best possible in a particular set of circumstances. An increasing number of cases similar to Joe's is being resolved in favor of discontinuing the ventilator. Emotional havoc could be the result to nurses who care for these patients. Individuals and institutions must begin planning strategies to deal with these and similar ethical dilemmas. Strategies might include anticipatory counseling, ethical decision making education programs and utilization of a nurse trained in ethics as a staff resource person. Nurses should attend and be involved in discussions of institutional ethics committees.(ABSTRACT TRUNCATED AT 250 WORDS)

This study examined the effect of an ethics course on the variables of ethical choice and ethical action in baccalaureate nursing students. Data were collected from 17 students who were enrolled in a three-credit elective course in ethics and from 20 students who were matched for placement in the curriculum but who were not enrolled in the ethics course. The ethics course consisted of study of the major ethical principles and theories as well as guided ethical case analysis with emphasis on the role and responsibilities of the nurse. Ethical choice and ethical action were measured by Ketefian's Judgment About Nursing Decisions. The variables of moral choice and moral action were positively correlated r = .87 (p less than .001) in the students who were enrolled in the ethics course and they were negatively correlated at r = -.32 (p .34) in the students who were not enrolled in the ethics course. Overall scores of the two groups on both column A (Ethical Choice) and column B (Ethical Action) were not significantly different. The total scores of the ethics group were higher. The results of this study lend support to the inclusion of a course in ethics in nursing curricula. Continued research into this area should continue to be a high priority.

Competency in ethical decision making is an identified expectation of the baccalaureate degree graduate. Values, both personal and professional, do not provide a systematic foundation for ethical decision making. The nurse is a unique health care provider and as such is faced with ethical decision of practice that are derived from and are relevant to that role. An understanding of ethical principles and theories as well as application of them to the role of the professional nurse is essential to ethical decision making in nursing practice. Seventy four per cent of recent graduates stated that the ethical content in their nursing programs most influenced their ethical decision-making skills, yet, only 23% used an ethical model or framework in analyzing and resolving the ethical dilemma of practice. The usual format for presentation of this content is a course in ethics. The content of such courses should include ethical theories and principles and their application to the practice of nursing. Teaching methodologies include guided case analysis and written responses to cases and current issues. Placement of separate required ethics courses remains a problem because of the overwhelming amount of content in baccalaureate degree curricula. Research has tentatively validated the need for a separate required course in nursing ethics. Further studies are necessary. If ethics content is integrated throughout the curriculum, it should be presented early with continual reinforcement and with the use of a specific ethics textbook. Research indicates that students who have completed a nursing ethics course not only know the correct ethical action but are more likely to implement it.(ABSTRACT TRUNCATED AT 250 WORDS)