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9 results on '"Gawron-Kiszka, Magdalena"'

2. Guidelines for the management of patients with Crohn’s disease. Recommendations of the Polish Society of Gastroenterology and the Polish National Consultant in Gastroenterology

Author

Łodyga, Michał, primary, Eder, Piotr, additional, Gawron-Kiszka, Magdalena, additional, Dobrowolska, Agnieszka, additional, Gonciarz, Maciej, additional, Hartleb, Marek, additional, Kłopocka, Maria, additional, Małecka-Wojciesko, Ewa, additional, Radwan, Piotr, additional, Reguła, Jarosław, additional, Zagórowicz, Edyta, additional, and Rydzewska, Grażyna, additional

Published
2021
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3. The HLA-DQβ1 insertion is a strong achalasia risk factor and displays a geospatial north–south gradient among Europeans

Author

Becker, Jessica, primary, Haas, Stephan L, additional, Mokrowiecka, Anna, additional, Wasielica-Berger, Justyna, additional, Ateeb, Zeeshan, additional, Bister, Jonna, additional, Elbe, Peter, additional, Kowalski, Marek, additional, Gawron-Kiszka, Magdalena, additional, Majewski, Marek, additional, Mulak, Agata, additional, Janiak, Maria, additional, Wouters, Mira M, additional, Schwämmle, Till, additional, Hess, Timo, additional, Veits, Lothar, additional, Niebisch, Stefan, additional, Santiago, José L, additional, de León, Antonio Ruiz, additional, de la Serna, Julio Pérez, additional, Urcelay, Elena, additional, Annese, Vito, additional, Latiano, Anna, additional, Fumagalli, Uberto, additional, Rosati, Riccardo, additional, Laghi, Luigi, additional, Cuomo, Rosario, additional, Lenze, Frank, additional, Sarnelli, Giovanni, additional, Müller, Michaela, additional, von Rahden, Burkhard HA, additional, Wijmenga, Cisca, additional, Lang, Hauke, additional, Czene, Kamila, additional, Hall, Per, additional, de Bakker, Paul IW, additional, Vieth, Michael, additional, Nöthen, Markus M, additional, Schulz, Henning G, additional, Adrych, Krystian, additional, Gąsiorowska, Anita, additional, Paradowski, Leszek, additional, Wallner, Grzegorz, additional, Boeckxstaens, Guy E, additional, Gockel, Ines, additional, Hartleb, Marek, additional, Kostic, Srdjan, additional, Dziurkowska-Marek, Anna, additional, Lindblad, Mats, additional, Nilsson, Magnus, additional, Knapp, Michael, additional, Thorell, Anders, additional, Marek, Tomasz, additional, Dąbrowski, Andrzej, additional, Małecka-Panas, Ewa, additional, and Schumacher, Johannes, additional

Published
2016
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4. A common variant in low density lipoprotein receptor-related protein 6 gene (LRP6) is associated with LDL-cholesterol: Tomaszewski LRP6 gene and LDL-C

Author

Tomaszewski, Maciej, Charchar, Fadi J., Barnes, Timothy, Gawron-Kiszka, Magdalena, Sedkowska, Agnieszka, Podolecka, Ewa, Kowalczyk, Jacek, Rathbone, Wendy, Kalarus, Zbigniew, Grzeszczak, Wladyslaw, Goodall, Alison H., Samani, Nilesh J., and Zukowska-Szczechowska, Ewa

Subjects
Adult, Male, Cholesterol, LDL, Coronary Artery Disease, Middle Aged, Lipid Metabolism, Polymorphism, Single Nucleotide, Article, Monocytes, Pedigree, Up-Regulation, Young Adult, Phenotype, Gene Frequency, Low Density Lipoprotein Receptor-Related Protein-6, Humans, Female, Genetic Predisposition to Disease, Poland, RNA, Messenger, LDL-Receptor Related Proteins, Dyslipidemias
Abstract

A rare mutation in low-density lipoprotein receptor-related protein 6 gene (LRP6) was identified as the primary molecular defect underlying monogenic form of coronary artery disease. We hypothesized that common variants in LRP6 could predispose subjects to elevated LDL-cholesterol (LDL-C).Twelve common (minor allele frequencyor =0.1) single nucleotide polymorphisms in LRP6 were genotyped in 703 individuals from 213 Polish pedigrees (Silesian Cardiovascular Study families). The family-based analysis revealed that the minor allele of rs10845493 clustered with elevated LDL-C in offspring more frequently than expected by chance (P=0.0053). The quantitative analysis restricted to subjects free of lipid-lowering treatment confirmed the association between rs10845493 and age-, sex-, and BMI-adjusted circulating levels of LDL-C in families as well as 2 additional populations - 218 unrelated subjects from Silesian Cardiovascular Study replication panel and 1138 individuals from Young Men Cardiovascular Association cohort (P=0.0268, P=0.0476, and P=0.0472, respectively). In the inverse variance weighted meta-analysis of the 3 populations each extra minor allele copy of rs10845493 was associated with 0.14 mmol/L increase in age-, sex-, and BMI-adjusted LDL-C (SE=0.05, P=0.0038).Common polymorphism in the gene underlying monogenic form of coronary artery disease impacts on risk of LDL-C elevation.

Published
2009

5. A Common Variant in Low-Density Lipoprotein Receptor–Related Protein 6 Gene (LRP6) Is Associated With LDL-Cholesterol

Author

Tomaszewski, Maciej, primary, Charchar, Fadi J., additional, Barnes, Timothy, additional, Gawron-Kiszka, Magdalena, additional, Sedkowska, Agnieszka, additional, Podolecka, Ewa, additional, Kowalczyk, Jacek, additional, Rathbone, Wendy, additional, Kalarus, Zbigniew, additional, Grzeszczak, Wladyslaw, additional, Goodall, Alison H., additional, Samani, Nilesh J., additional, and Zukowska-Szczechowska, Ewa, additional

Published
2009
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6. Guidelines for the management of ulcerative colitis. Recommendations of the Polish Society of Gastroenterology and the Polish National Consultant in Gastroenterology.

Author

Eder, Piotr, Łodyga, Michał, Gawron-Kiszka, Magdalena, Dobrowolska, Agnieszka, Gonciarz, Maciej, Hartleb, Marek, Kłopocka, Maria, Małecka-Wojciesko, Ewa, Radwan, Piotr, Reguła, Jarosław, Zagórowicz, Edyta, Banasiewicz, Tomasz, Durlik, Marek, and Rydzewska, Grażyna

Subjects
*ULCERATIVE colitis, *GASTROENTEROLOGY, *LIKERT scale, *CONSULTANTS
Abstract

This paper is an update of the diagnostic and therapeutic recommendations of the National Consultant for Gastroenterology and the Polish Society of Gastroenterology from 2013. It contains 49 recommendations for the diagnosis and treatment, both pharmacological and surgical, of ulcerative colitis in adults. The guidelines were developed by a group of experts appointed by the Polish Society of Gastroenterology and the National Consultant in the field of Gastroenterology. The methodology related to the GRADE methodology was used to assess the quality of available evidence and the strength of therapeutic recommendations. The degree of expert support for the proposed statements was assessed on a 6-point Likert scale. Voting results, together with comments, are included with each statement. [ABSTRACT FROM AUTHOR]

Published
2023
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9. The HLA-DQβ1 insertion is a strong achalasia risk factor and displays a geospatial north-south gradient among Europeans

Author

Justyna Wasielica-Berger, Giovanni Sarnelli, Antonio Ruiz de León, Michael Vieth, Anders Thorell, Magdalena Gawron-Kiszka, Michaela Müller, Andrzej Dąbrowski, Per Hall, Jonna Bister, V. Annese, Markus M. Nöthen, Burkhard H.A. von Rahden, Magnus Nilsson, Guy E. Boeckxstaens, Anna Mokrowiecka, Cisca Wijmenga, Julio Perez de la Serna, Leszek Paradowski, Marek L. Kowalski, Henning G. Schulz, Uberto Fumagalli, Tomasz Marek, Marek Majewski, Stephan L. Haas, Johannes Schumacher, Agata Mulak, Srdjan Kostic, Riccardo Rosati, Grzegorz Wallner, Till Schwämmle, Lothar Veits, Marek Hartleb, Zeeshan Ateeb, Michael Knapp, Jessica Becker, Anna Latiano, Paul I.W. de Bakker, Ines Gockel, Stefan Niebisch, Elena Urcelay, Krystian Adrych, Mats Lindblad, Frank Lenze, Hauke Lang, Anita Gąsiorowska, Ewa Małecka-Panas, Luigi Laghi, Mira M. Wouters, Timo Hess, Maria Janiak, Anna Dziurkowska-Marek, Peter Elbe, Rosario Cuomo, Jose Luis Santiago, Kamila Czene, Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI), Department of Health and Life Sciences, Becker, Jessica, Haas, Stephan L, Mokrowiecka, Anna, Wasielica Berger, Justyna, Ateeb, Zeeshan, Bister, Jonna, Elbe, Peter, Kowalski, Marek, Gawron Kiszka, Magdalena, Majewski, Marek, Mulak, Agata, Janiak, Maria, Wouters, Mira M, Schwämmle, Till, Hess, Timo, Veits, Lothar, Niebisch, Stefan, Santiago, José L, de León, Antonio Ruiz, de la Serna, Julio Pérez, Urcelay, Elena, Annese, Vito, Latiano, Anna, Fumagalli, Uberto, Rosati, Riccardo, Laghi, Luigi, Cuomo, Rosario, Lenze, Frank, Sarnelli, Giovanni, Müller, Michaela, von Rahden, Burkhard HA, Wijmenga, Cisca, Lang, Hauke, Czene, Kamila, Hall, Per, de Bakker, Paul IW, Vieth, Michael, Nöthen, Markus M, Schulz, Henning G, Adrych, Krystian, Gąsiorowska, Anita, Paradowski, Leszek, Wallner, Grzegorz, Boeckxstaens, Guy E, Gockel, Ine, Hartleb, Marek, Kostic, Srdjan, Dziurkowska Marek, Anna, Lindblad, Mat, Nilsson, Magnu, Knapp, Michael, Thorell, Ander, Marek, Tomasz, Dąbrowski, Andrzej, Małecka Panas, Ewa, Schumacher, Johannes, Schumacher, J, Becker, J, Haas, S, Mokrowiecka, A, Wasielica Berger, J, Ateeb, Z, Bister, J, Elbe, P, Kowalski, M, Gawron Kiszka, M, Majewski, M, Mulak, A, Janiak, M, Wouters, M, Schwämmle, T, Hess, T, Veits, L, Niebisch, S, Santiago, Jl, Ruiz de León, A, Pérez de la Serna, J, Urcelay, E, Annese, V, Latiano, A, Fumagalli, U, Laghi, L, Cuomo, R, Lenze, F, Sarnelli, G, Müller, M, von Rahden, B, Wijmenga, C, Lang, H, Czene, K, Hall, P, de Bakker, P, Vieth, M, Nöthen, M, Schulz, H, Adrych, K, Gąsiorowska, A, Paradowski, L, Wallner, G, Boeckxstaens, G, Gockel, I, Hartleb, M, Kostic, S, Dziurkowska Marek, A, Lindblad, Nilsson, M, Knapp, M, Thorell, A, Marek, T, Dąbrowski, A, and Małecka Panas, E.

Subjects
0301 basic medicine, Male, European Continental Ancestry Group, Short Report, Achalasia, Human leukocyte antigen, White People, 03 medical and health sciences, 0302 clinical medicine, Swedish population, Genetic, Genetics, esophageal achalasia, Mutation Rate, Genetics, medicine, otorhinolaryngologic diseases, Prevalence, HLA-DQ beta-Chains, Humans, In patient, Esophagus, Risk factor, Genetics (clinical), HLA-DQ beta-Chain, Polymorphism, Genetic, business.industry, European population, medicine.disease, Esophageal Achalasia, Europe, Mutagenesis, Insertional, 030104 developmental biology, medicine.anatomical_structure, Attributable risk, 030211 gastroenterology & hepatology, Female, business, Human, Demography
Abstract

Idiopathic achalasia is a severe motility disorder of the esophagus and is characterized by a failure of the lower esophageal sphincter to relax due to a loss of neurons in the myenteric plexus. Most recently, we identified an eight-amino-acid insertion in the cytoplasmic tail of HLA-DQβ1 as strong achalasia risk factor in a sample set from Central Europe, Italy and Spain. Here, we tested whether the HLA-DQβ1 insertion also confers achalasia risk in the Polish and Swedish population. We could replicate the initial findings and the insertion shows strong achalasia association in both samples (Poland P=1.84 × 10(-04), Sweden P=7.44 × 10(-05)). Combining all five European data sets - Central Europe, Italy, Spain, Poland and Sweden - the insertion is achalasia associated with Pcombined=1.67 × 10(-35). In addition, we observe that the frequency of the insertion shows a geospatial north-south gradient. The insertion is less common in northern (around 6-7% in patients and 2% in controls from Sweden and Poland) compared with southern Europeans (~16% in patients and 8% in controls from Italy) and shows a stronger attributable risk in the southern European population. Our study provides evidence that the prevalence of achalasia may differ between populations.European Journal of Human Genetics advance online publication, 6 January 2016; doi:10.1038/ejhg.2015.262. ispartof: European Journal of Human Genetics vol:24 issue:8 pages:1228-1231 ispartof: location:England status: published

Published
2016

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