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18 results on '"Gay, Cindy"'

1. Message from the NABT Board of Directors

Author

Finazzo, Susan, Melton, Bob, Cowles, Elizabeth, Christenson, Steven D., Annee, Sherry, Carroll, Margaret, Gay, Cindy, Royal, Brenda, and Reeves-Pepin, Jaclyn

Published
2017

4. Conserved-region MVA vaccines can shift HIV T cell immunodominance in PWH on ART - the M&M Study

Author

Xu, Yinyan, primary, Samir, shahryat, additional, Weideman, Ann Marie K., additional, Kallon, Sallay, additional, Conrad, Shayla, additional, Shaw, Fiona, additional, Warren, Joanna, additional, Fernandez, Maria Abad, additional, Fox, Lawrence, additional, Margolis, David M., additional, Hudgens, Michael G., additional, Hanke, Tomas, additional, Kuruc, JoAnn, additional, Gay, Cindy, additional, and Goonetilleke, Nilu, additional

Published
2022
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5. CD8 T Cell Virus Inhibition Assay Protocol

Author

Xu, Yinyan, primary, Weideman, Ann, additional, Abad-Fernandez, Maria, additional, Mollan, Katie, additional, Kallon, Sallay, additional, Samir, Shahryar, additional, Warren, Joanna, additional, Clutton, Genevieve, additional, Roan, Nadia, additional, Adimora, Adaora, additional, Archin, Nancie, additional, Kuruc, JoAnn, additional, Gay, Cindy, additional, Hudgens, Michael, additional, and Goonetilleke, Nilu, additional

Published
2022
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7. Reliable Estimation of CD8 T Cell Inhibition of In Vitro HIV-1 Replication.

Author

Xu, Yinyan, Weideman, Ann Marie, Abad-Fernandez, Maria, Mollan, Katie R., Kallon, Sallay, Samir, Shahryar, Warren, Joanna A., Clutton, Genevieve, Roan, Nadia, Adimora, Adaora A., Archin, Nancie, Kuruc, JoAnn, Gay, Cindy, Hudgens, Michael G., and Goonetilleke, Nilu

Subjects
T cells, HIV, HIV-positive persons, HIV infections, CELL populations
Abstract

The HIV-1 viral inhibition assay (VIA) measures CD8 T cell-mediated inhibition of HIV replication in CD4 T cells and is increasingly used for clinical testing of HIV vaccines and immunotherapies. The VIA has multiple sources of variability arising from in vitro HIV infection and co-culture of two T cell populations. Here, we describe multiple modifications to a 7-day VIA protocol, the most impactful being the introduction of independent replicate cultures for both HIV infected-CD4 (HIV-CD4) and HIV-CD4:CD8 T cell cultures. Virus inhibition was quantified using a ratio of weighted averages of p24+ cells in replicate cultures and the corresponding 95% confidence interval. An Excel template is provided to facilitate calculations. Virus inhibition was higher in people living with HIV suppressed on antiretroviral therapy (n=14, mean: 40.0%, median: 43.8%, range: 8.2 to 73.3%; p < 0.0001, two-tailed, exact Mann-Whitney test) compared to HIV-seronegative donors (n = 21, mean: -13.7%, median: -14.4%, range: -49.9 to 20.9%) and was stable over time (n = 6, mean %COV 9.4%, range 0.9 to 17.3%). Cross-sectional data were used to define 8% inhibition as the threshold to confidently detect specific CD8 T cell activity and determine the minimum number of culture replicates and p24+ cells needed to have 90% statistical power to detect this threshold. Last, we note that, in HIV seronegative donors, the addition of CD8 T cells to HIV infected CD4 T cells consistently increased HIV replication, though the level of increase varied markedly between donors. This co-culture effect may contribute to the weak correlations observed between CD8 T cell VIA and other measures of HIV-specific CD8 T cell function. [ABSTRACT FROM AUTHOR]

Published
2021
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8. Quantifying Virus Escape from T Cells in the Latent HIV Reservoir

Author

Warren, Joanna A, primary, Zhou, Shuntai, additional, Xu, Yinyan, additional, Moeser, Matthew, additional, Kirchherr, Jenn, additional, Sung, Julia, additional, Roan, Nadia, additional, Adimora, Adaora, additional, Kuruc, JoAnn, additional, Gay, Cindy, additional, Margolis, David, additional, Archin, Nancie, additional, Swanstrom, Ronald, additional, and Goonetilleke, Nilu, additional

Published
2019
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9. Decreased Tenofovir Diphosphate Concentrations in a Transgender Female Cohort: Implications for Human Immunodeficiency Virus Preexposure Prophylaxis

Author

Cottrell, Mackenzie L, primary, Prince, Heather M A, primary, Schauer, Amanda P, primary, Sykes, Craig, primary, Maffuid, Kaitlyn, primary, Poliseno, Amanda, primary, Chun, Tae-Wook, primary, Huiting, Erin, primary, Stanczyk, Frank Z, primary, Peery, Anne F, primary, Dellon, Evan S, primary, Adams, Jessica L, primary, Gay, Cindy, primary, and Kashuba, Angela D M, primary

Published
2019
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11. Do T cells from HIV-infected individuals have normal metabolic function?

Author

Clutton, Genevieve Tyndale, primary, Council, Olivia, additional, Xu, Yinyan, additional, Warren, Joanna, additional, Lee, De’Ashia, additional, Fernandez, Maria Abad, additional, Archin, Nancie, additional, Kuruc, JoAnn, additional, Eron, Joseph, additional, Gay, Cindy, additional, Margolis, David, additional, and Goonetilleke, Nilu, additional

Published
2017
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12. Effects of different treatment regimens on T cell function in acute HIV infection.

Author

Clutton, Genevieve Tyndale, primary, Xu, Yinyan, additional, Fernandez, Maria Abad, additional, Crooks, Amanda, additional, Turner, Blair, additional, Maponga, Nicole, additional, Cope, Anna, additional, Fiscus, Susan, additional, McGee, Kara, additional, McKellar, Mehri, additional, Kuruc, JoAnn, additional, Ferrari, Guido, additional, Margolis, David, additional, Hicks, Charles, additional, Eron, Joseph, additional, Gay, Cindy, additional, and Goonetilleke, Nilu, additional

Published
2016
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13. Detection of acute HIV infection in two evaluations of a new HIV diagnostic testing algorithm--United States, 2011-2013

Author

Geren, Kara, Moore, Eric, Tomlinson, Cheri, Hobohm, Dan, Gardner, Ann, Reardon-Maynard, Deborah, Gay, Cindy, Hightow-Weidman, Lisa B., Pandori, Mark W., Moss, Nicholas, Westheimer, Emily, Tsoi, Benjamin, Branson, Bernard M., and Peters, Philip J.

Subjects
United States. Food and Drug Administration -- Analysis, HIV (Viruses) -- Health aspects -- Analysis, Medical tests -- Health aspects -- Analysis, HIV testing -- Health aspects -- Analysis, RNA -- Health aspects -- Analysis, Algorithms -- Health aspects -- Analysis, HIV infection -- Health aspects -- Analysis, Algorithm, Health
Abstract

The highly infectious phase of acute human immunodeficiency virus (HIV) infection, defined as the interval between the appearance of HIV RNA in plasma and the detection of HIV-1--specific antibodies, contributes [...]

Published
2013

15. The Multispot rapid HIV-1/HIV-2 differentiation assay is comparable with the Western blot and an immunofluorescence assay at confirming HIV infection in a prospective study in three regions of the United States

Author

Pandori, Mark W., primary, Westheimer, Emily, additional, Gay, Cindy, additional, Moss, Nicholas, additional, Fu, Jie, additional, Hightow-Weidman, Lisa B., additional, Craw, Jason, additional, Hall, Laura, additional, Giancotti, Francesca R., additional, Mak, Mae Ling, additional, Madayag, Carmela, additional, Tsoi, Benjamin, additional, Louie, Brian, additional, Patel, Pragna, additional, Owen, S. Michele, additional, and Peters, Philip J., additional

Published
2013
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16. Make it our mission

Author

Gay, Cindy

Subjects
Business, Food and beverage industries
Abstract

'I applaud Toby Cosgrove's efforts to remove McDonalds and Pizza Hut from hospital premises. 'Improving the health of the people they serve' should be in every hospital's mission statement. While [...]

Published
2005

17. LETTERS TO THE EDITOR.

Author

Gay, Cindy, Rea Jr., Mark A. J., Svoboda, Joyce, Thurnhofer, Walter, and Silverstein, Joel

Subjects
LETTERS to the editor, HOSPITAL food service, FAST food restaurants, FOOD, HEALTH facilities
Abstract

Presents letters to the editor in response to the Food Service Director Opinion column published in the January 15, 2005 issue which deals with food service facilities at the Cleveland Health Clinic. Removal of McDonalds and Pizza Hut fast food restaurants from hospital premises; Inclusion of a fast food franchise in a healthcare organization; Significance of good food choices.

Published
2005

18. HIV infection among partners of HIV-infected black men who have sex with Men - North Carolina, 2011-2013.

Author

Peters PJ, Gay C, Beagle S, Shankar A, Switzer WM, and Hightow-Weidman LB

Subjects
Black or African American statistics & numerical data, Female, HIV Infections prevention & control, Humans, Male, North Carolina epidemiology, Black or African American psychology, HIV Infections ethnology, Homosexuality, Male ethnology, Sexual Partners
Abstract

The incidence of human immunodeficiency virus (HIV) infection has significantly increased among black men who have sex with men (MSM) in the United States, and young black MSM have been disproportionately affected. HIVinfected black MSM are also less likely to engage in HIV care and achieve viral suppression than MSM of other races/ethnicities. Engaging in care and achieving viral suppression is a multistep process that starts with diagnosis. Diagnosing persons unaware of their HIV status traditionally has been a critical component of HIV partner services, but partner services also provide an important opportunity to reengage HIVinfected partners in medical care. One approach for partner services involves contacting partners of persons with newly diagnosed HIV infection and using sexual and social network and molecular phylogenetic data to improve the continuum of HIV care among black MSM. To evaluate the effectiveness of that approach, results from a prospective partner services study conducted in North Carolina were examined, and one of the partner networks identified through this study was evaluated in depth. Overall, partner services were provided to 30 black, HIV-infected MSM who named 95 sex partners and social contacts, of whom 39 (41%) previously had been diagnosed with HIV infection. The partner network evaluation demonstrated that HIV-infected and HIV-negative partners were frequently in the same network, and that the majority of HIV-infected partners were already aware of their diagnosis but had not achieved viral suppression. Using partner services to ensure that HIV-infected partners are linked to care and treatment might reduce HIV transmission and might improve outcomes along the continuum of care.

Published
2014

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