1. Thioterpenoids as Potential Antithrombotic Drugs: Molecular Docking, Antiaggregant, Anticoagulant and Antioxidant Activities.
- Author
-
Ksenofontov AA, Bocharov PS, Antina EV, Shevchenko OG, Samorodov AV, Gilfanov IR, Pavelyev RS, Ostolopovskaya OV, Startseva VA, Fedyunina IV, Azizova ZR, Gaysin SI, Pestova SV, Izmest'ev ES, Rubtsova SA, Khelkhal MA, and Nikitina LE
- Subjects
- Animals, Molecular Docking Simulation, Anticoagulants pharmacology, Sulfoxides chemistry, Sulfones chemistry, Sulfides chemistry, Antioxidants pharmacology, Antioxidants chemistry, Fibrinolytic Agents pharmacology
- Abstract
Natural monoterpenes and their derivatives are widely considered as effective ingredients for the design and production of new biologically active compounds with high antioxidant, antimicrobial and anti-protozoa properties. In this study, we synthesized two series of thiotherpenoids "sulfide-sulfoxide-sulfone", with different bicyclic monoterpene skeleton (bornane and pinane) structures. The effect of the obtained compounds on platelet aggregation was investigated by using the molecular docking technique. The obtained data revealed that all the synthesized compounds may act as potential inhibitors of platelet aggregation. Moreover, the studied sulfides have shown high antioxidant activity as revealed by lipid peroxidation (LPO) process inhibition in a non-cellular substrate containing animal lipids. The sulfides were able to inhibit erythrocyte oxidative hemolysis, to reduce the accumulation of secondary LPO products in cells and to prevent the oxidation of native oxyhemoglobin. Additionally, the corresponding sulfones and sulfoxides exhibited insignificant antioxidant activity. However, the sulfides were found to exhibit significant antiaggregant and anticoagulant effects. These findings suggest as well that the sulfides could serve as a leader compound for future research and possible practical applications.
- Published
- 2022
- Full Text
- View/download PDF