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Aluminum alloy is widely used for its light weight characteristic and excellent corrosion resistance. Cold spraying technology is one effective method to fabricate the Al anti - corrosive coatings owing to its high speed and low temperature deposition characterization. In this work, the aluminum powder was mixed with ceramic phase powder to prepare the composite powder by mechanical mixing, and Al5056/Al5056 - Al2O3/Al5056 - SiC/Al5056 - WC coatings were prepared by cold spraying on the Al1060 substrate. The porosity and content of the ceramic phase in the coating were studied through Image - Pro Plus software, and microhardness testing was carried out on the composite coatings. Meanwhile, the effects of ceramic types on the electrochemical properties of composite coatings were studied, and the corrosion resistance of the coating was analyzed in combination with the corrosion morphology. Results showed that the ceramic phase could be effectively deposited, but the self aggregation of ceramic particles during the spraying process affected the compaction of the coating. Besides, Al5056 and Al5056 - Al2O3 coatings exhibited high impedance modulus, but the self corrosion current density and corrosion rate of Al5056 - Al2O3 coatings were reduced by an order of magnitude compared with other coatings. Thus, the Al5056 - Al2O3 coating showed the best corrosion resistance performance.

Background To assess the efficacy and safety of tucidinostat plus exemestane as a neoadjuvant strategy in early-stage breast cancer. Methods This prospective, open-label, single-arm phase II trial enrolled patients with stage II-III breast cancer with hormone receptor-positive and human epidermal growth factor receptor 2 (HER2)-negative. Eligible patients received tucidinostat plus exemestane, and then breast-conserving surgery (BCS) or modified radical mastectomy. Results Among 20 enrolled patients, 3 of them achieved preoperative endocrine prognostic index (PEPI) score of 0. Additionally, complete cell cycle arrest was observed in 7, radiologic objective response rate in 10, and disease control rate in 20 patients, pathological complete response in 1 patient, and 5 patients performed BCS. Ki67 suppression from baseline to surgery was observed in 17 of patients, with the Ki67 change ratio of −73.5%. Treatment-emergent adverse event included neutropenia, leukopenia, thrombocytopenia, lymphopenia, hypoalbuminemia, aspartate aminotransferase elevation, glutamyl transpeptidase elevation, anemia, and alanine aminotransferase elevation. Conclusions Despite the rate of PEPI score 0 was not high, tucidinostat plus exemestane as a neoadjuvant therapy might be well tolerated and showed promising clinical responses in patients with early hormone receptor-positive, HER2-negative breast cancer. To clarify the safety and efficacy of this strategy, further investigation is warranted. Clinical Trial Registration ChiCTR2100046678. [ABSTRACT FROM AUTHOR]

Aiming at the problems existing in the process of river water quality detection, this paper proposes a BOD prediction model based on GA-RandomForest optimization, and evaluates the model through MAE and MAPE, and achieves good results. And the forecast experiment is carried out through the water quality data of Chaohu Lake for 3 months. The experimental results show that the BOD prediction model based on GA-RandomForest is effective, and the model is based on higher accuracy.

Background: The prevalence of Tobacco Use Disorder (TUD) represents a significant and pressing global public health concern, with far-reaching and deleterious consequences for individuals, communities, and healthcare systems. The craving caused by smoking cue is an important trigger for relapse, fundamentally hindering the cessation of cigarette smoking. Mindfulness interventions focusing on cue-reactivity was effective for the treatment of related dependence. Brief mindfulness training (BMT) meets the short-term needs for intervention but the effects still need to be examined. The objective of the present study is to investigate the impact of BMT intervention on smoking cue-reactivity among Chinese college students with TUD, to uncover the dynamic models of brain function involved in this process. Method: A randomized control trial (RCT) based on electroencephalography (EEG) was designed. We aim to recruit 90 participants and randomly assign to the BMT and control group (CON) with 1:1 ratio. A brief mindfulness training will be administered to experimental group. After the intervention, data collection will be conducted in the follow-up stage with 5 timepoints of assessments. EEG data will be recorded during the smoking cue-reactivity task and 'STOP' brief mindfulness task. The primary outcomes include subjective reports of smoking craving, changes in EEG indicators, and mindfulness measures. The secondary outcomes will be daily smoking behaviours, affect and impulsivity, as well as indicators reflecting correlation between mindfulness and smoking cue-reactivity. To evaluate the impact of mindfulness training, a series of linear mixed-effects models will be employed. Specifically, within-group effects will be examined by analysing the longitudinal data. Additionally, the effect size for all statistical measurements will be reported, offering a comprehensive view of the observed effects. Discussion: The current study aims to assess the impact of brief mindfulness-based intervention on smoking cue-reactivity in TUD. It also expected to enhance our understanding of the underlying processes involved in brain function and explore potential EEG biomarkers at multiple time points. Trial registration: Trial registration number: ChiCTR2300069363, registered on 14 March 2023. Protocol Version 1.0., 10 April 2023. [ABSTRACT FROM AUTHOR]

This article discusses the heterogeneity of gastric adenocarcinoma (GAC) and its impact on patient outcomes. The study used single-cell RNA sequencing and T-cell receptor sequencing to analyze tumor samples from nine GAC patients. The researchers identified different subpopulations of cells within the tumors and found that tumors with higher intratumor heterogeneity (ITH) exhibited increased copy number variation, proliferation, and hypoxia. Additionally, the study found an immunosuppressive tumor microenvironment (TME) associated with higher ITH, including the presence of M2 macrophages and exhausted T cells. The findings suggest that ITH can serve as a prognostic marker for recurrence and provide insights for immunotherapeutic strategies. However, the study had limitations in sample size and longitudinal observations, and further research is needed. [Extracted from the article]