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3. Endovascular thrombectomy versus medical management on outcomes with infarct volumes more than 70 mL

Author

Han, Nannan, primary, Zhang, Xiaobo, additional, Zhang, Yu, additional, Liu, Yu, additional, Ma, Haojun, additional, Ge, Hanming, additional, Wang, Yanfei, additional, Li, Shilin, additional, Yan, Xudong, additional, Li, Tengfei, additional, Wu, Yulun, additional, Ma, Juan, additional, Shi, Wenzhen, additional, Zhang, Gejuan, additional, Tian, Ye, additional, and Chang, Mingze, additional

Published
2024
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4. Predicting 3-month Functional Outcome After Endovascular Thrombectomy in Patients with Anterior Circulation Occlusion with an Arterial Transit Artifact Grading System

Author

Zhang, Xiaobo, primary, Han, Nannan, additional, Zhang, Yu, additional, Yuan, Wenting, additional, Kan, Shangguang, additional, Zhang, Gejuan, additional, Ma, Haojun, additional, Ge, Hanming, additional, Du, Chengxue, additional, Gao, Yanjun, additional, Li, Shilin, additional, Yan, Xudong, additional, Shi, Wenzhen, additional, Tian, Ye, additional, and Chang, Mingze, additional

Published
2023
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7. Nomogram to predict unfavorable outcome of endovascular thrombectomy for large ischemic core

Author

Han, Nannan, primary, Zhang, Xiaobo, additional, Zhang, Yu, additional, Liu, Yu, additional, Zhang, Yongqin, additional, Ma, Haojun, additional, Ge, Hanming, additional, Li, Shilin, additional, Zhang, Xiao, additional, Yan, Xudong, additional, Li, Tengfei, additional, Gao, Bin, additional, Du, Chengxue, additional, Ji, Xinchao, additional, Shi, Wenzhen, additional, Tian, Ye, additional, and Chang, Mingze, additional

Published
2023
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9. The relationship between vertebrobasilar artery calcification and intracranial atherosclerosis-related occlusion in thrombectomy

Author

Han, Nannan, primary, Zhang, Gejuan, additional, Yang, Shiyao, additional, Ma, Haojun, additional, Ge, Hanming, additional, Zhang, Xiao, additional, Li, Shilin, additional, Wang, Yanfei, additional, Fan, Xiaonan, additional, Yin, Yanling, additional, Gao, Yanjun, additional, Shi, Wenzhen, additional, Zhang, Xiaobo, additional, Chang, Mingze, additional, and Tian, Ye, additional

Published
2022
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11. Impact of Body Temperature in Patients With Acute Basilar Artery Occlusion: Analysis of the BASILAR Database

Author

Zhang, Wenbin, primary, Li, Fengli, additional, Zhang, Cai, additional, Lei, Bo, additional, Deng, Wei, additional, Zeng, Hongliang, additional, Yu, Yang, additional, Wu, Junxiong, additional, Peng, Daizhou, additional, Tian, Zhenxuan, additional, Zhu, Xiurong, additional, Hu, Zhizhou, additional, Hong, Yifan, additional, Li, Wenbo, additional, Ge, Hanming, additional, Xu, Xinwei, additional, Ju, Dongsheng, additional, Yang, Shunyu, additional, Pan, Chengde, additional, Zi, Wenjie, additional, and Wang, Shouchun, additional

Published
2022
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12. MicroRNA-769-5p Promotes the Growth of Glioma Cells by Targeting Lysine Methyltransferase 2A [Retraction]

Author

Chang,Mingze, Yan,Peng, Zhang,Bei, Zhang,Gejuan, Wang,Juanhong, Ge,Hanming, Han,Nannan, Du,Chengxue, Shi,Wenzhen, Tian,Ye, Chang,Mingze, Yan,Peng, Zhang,Bei, Zhang,Gejuan, Wang,Juanhong, Ge,Hanming, Han,Nannan, Du,Chengxue, Shi,Wenzhen, and Tian,Ye

Abstract

Chang M, Yan P, Zhang B, et al. Onco Targets Ther. 2019;12:9177–9187. At the authors request, the Editor and Publisher of OncoTargets and Therapy wish to retract the published article. Following publication, the authors performed an STR analysis on the A172 cells used in the study and they were determined to be contaminated with HeLa cells. In addition, the authors were unable to provide adequate original data for their study and deemed the findings to be unreliable. The authors requested for the article to be retracted and the Editor agreed with this decision. Our decision-making was informed by our policy on publishing ethics and integrity and the COPE guidelines on retraction. The retracted article will remain online to maintain the scholarly record, but it will be digitally watermarked on each page as “Retracted”. This retraction relates to this paper

Published
2022

13. Efficacy and Safety of Intravenous Tirofiban Before Endovascular Thrombectomy for Large Vessel Occlusion Stroke (RESCUE BT): A Multicentre, Randomised, Double-Blind, Placebo-Controlled Trial

Author

Qiu, Zhongming, primary, Li, Fengli, additional, Sang, Hongfei, additional, Luo, Weidong, additional, Liu, Shuai, additional, Liu, Wenhua, additional, Guo, Zhangbao, additional, Li, Huagang, additional, Sun, Dong, additional, Huang, Wenguo, additional, Zhang, Min, additional, Dai, Weipeng, additional, Zhou, Peiyang, additional, Deng, Wei, additional, Zhou, Zhiming, additional, Huang, Xianjun, additional, Lei, Bo, additional, Li, Jinglun, additional, Yuan, Zhengzhou, additional, Song, Bo, additional, Miao, Jian, additional, Liu, Shudong, additional, Jin, Zhenglong, additional, Zeng, Guoyong, additional, Zeng, Hongliang, additional, Yuan, Junjie, additional, Wen, Changming, additional, Yu, Yang, additional, Yuan, Guangxiong, additional, Wu, Junxiong, additional, Long, Chen, additional, Luo, Jun, additional, Tian, Zhenxuan, additional, Zheng, Chong, additional, Hu, Zhizhou, additional, Wang, Shouchun, additional, Wang, Tao, additional, Qi, Li, additional, Li, Rongzong, additional, Wan, Yue, additional, Ke, Yingbing, additional, Wu, Youlin, additional, Zhu, Xiurong, additional, Kong, Weilin, additional, Huang, Jiacheng, additional, Peng, Daizhou, additional, Chang, Mingze, additional, Ge, Hanming, additional, Shi, Zhonghua, additional, Yan, Zhizhong, additional, Du, Jie, additional, Jin, Ying, additional, Ju, Dongsheng, additional, Huang, Chuming, additional, Hong, Yifan, additional, Liu, Tianzhu, additional, Zhao, Wenlong, additional, Wang, Jian, additional, Zheng, Bo, additional, Wang, Li, additional, Liu, Shugai, additional, Luo, Xiaojun, additional, Luo, Shiwei, additional, Xu, Xinwei, additional, Hu, Jinrong, additional, Pu, Jie, additional, Chen, Shengli, additional, Sun, Yaxuan, additional, Jiang, Shunfu, additional, Wei, Liping, additional, Fu, Xinmin, additional, Bai, Yongjie, additional, Yang, Shunyu, additional, Hu, Wei, additional, Zhang, Guling, additional, Pan, Chengde, additional, Zhang, Shuai, additional, Wang, Yan, additional, Cao, Wenfeng, additional, Yang, Shiquan, additional, Zhang, Jun, additional, Guo, Fuqiang, additional, Wen, Hongbin, additional, Zhang, Jinghua, additional, Song, Jiaxing, additional, Yue, Chengsong, additional, Li, Linyu, additional, Wu, Deping, additional, Tian, Yan, additional, Yang, Jie, additional, Lu, Mengjie, additional, Saver, Jeffrey, additional, Gomes Nogueira, Raul, additional, Zi, Wenjie, additional, and Yang, QingWu, additional

Published
2022
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14. Hyperattenuated Lesions on Immediate Non-contrast CT After Endovascular Therapy Predict Intracranial Hemorrhage in Patients With Acute Ischemic Stroke: A Retrospective Propensity Matched Study

Author

Han, Nannan, primary, Zhang, Gejuan, additional, Li, Yige, additional, Ma, Haojun, additional, Ge, Hanming, additional, Zhang, Xiao, additional, Zhao, Yong, additional, Li, Shilin, additional, Zhang, Leshi, additional, Gao, Yanjun, additional, Shi, Wenzhen, additional, Yan, Peng, additional, Li, Wu, additional, Chang, Mingze, additional, and Tian, Ye, additional

Published
2021
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15. MicroRNA-769-5p Promotes the Growth of Glioma Cells by Targeting Lysine Methyltransferase 2A [Corrigendum]

Author

Chang,Mingze, Yan,Peng, Zhang,Bei, Zhang,Gejuan, Wang,Juanhong, Ge,Hanming, Han,Nannan, Du,Chengxue, Shi,Wenzhen, Tian,Ye, Chang,Mingze, Yan,Peng, Zhang,Bei, Zhang,Gejuan, Wang,Juanhong, Ge,Hanming, Han,Nannan, Du,Chengxue, Shi,Wenzhen, and Tian,Ye

Abstract

Chang M, Yan P, Zhang B, et al. Onco Targets Ther. 2019;12:9177–9187. The authors have advised that the affiliation list on page 9177 is incorrect. The correct affiliation list is:1Department of Neurology, Xi’an No.3 Hospital of Northwest University, Xi’an 710069, People’s Republic of China; 2Department of Neurology, The Affiliated Hospital of Northwest University, Xi’an 710021, People’s Republic of China; 3The College of Life Sciences, Northwest University, Xi’an 710069, People’s Republic of China; 4Department of Neurology, The First Affiliated Hospital of Xi’an Medical University, Xi’an 710077, People’s Republic of China; 5Department of Pathology, Xi’an No.3 Hospital of Northwest University, Xi’an 710069, People’s Republic of China; 6Department of Pathology, Xi’an Central Hospital, Xi’an 71000, People’s Republic of China The authors apologize for this error. Read the original article

Published
2021

18. MicroRNA-769-5p Promotes The Growth Of Glioma Cells By Targeting Lysine Methyltransferase 2A

Author

Chang,Mingze, Yan,Peng, Zhang,Bei, Zhang,Gejuan, Wang,Juanhong, Ge,Hanming, Han,Nannan, Du,Chengxue, Shi,Wenzhen, Tian,Ye, Chang,Mingze, Yan,Peng, Zhang,Bei, Zhang,Gejuan, Wang,Juanhong, Ge,Hanming, Han,Nannan, Du,Chengxue, Shi,Wenzhen, and Tian,Ye

Abstract

This paper has been retracted.Mingze Chang, 1, 2 Peng Yan, 3 Bei Zhang, 4 Gejuan Zhang, 1 Juanhong Wang, 5, 6 Hanming Ge, 1 Nannan Han, 1 Chengxue Du, 1 Wenzhen Shi, 1 Ye Tian 2 1Department of Neurology, Xi’an No. 3 Hospital, Xi’an 710021, People’s Republic of China; 2Department of Neurology, The Affiliated Hospital of Northwest University, Xi’an 710021, People’s Republic of China; 3The College of Life Sciences, Northwest University, Xi’an 710069, People’s Republic of China; 4Department of Neurology, The First Affiliated Hospital of Xi’an Medical University, Xi’an 710077, People’s Republic of China; 5Department of Pathology, Xi’an No.3 Hospital, Xi’an 710021, People’s Republic of China; 6Departments of Pathology, Xi’an Central Hospital, Xi’an 71000, People’s Republic of ChinaCorrespondence: Ye TianDepartment of Neurology, the Affiliated Hospital of Northwest University, 10 East Section of Fengcheng 3rd Road, Xi’an 710021, People’s Republic of ChinaTel +86-029-87268355Email tianye_xian@163.comBackground: Accumulating evidence supports the involvement of microRNAs (miRNAs) in the progression of human cancers including glioma. Recently, miR-769-5p has been reported to play a tumor suppressive role in colorectal cancer and lung cancer, whereas it exerts an oncogenic role in melanoma. However, the role of miR-769-5p and its related mechanism are poorly elucidated.Methods: The levels of miR-769-5p in glioma tissues and adjacent non-tumor tissues were detected by qRT-PCR. In addition, the effects of miR-769-5p on cell proliferation and apoptosis were evaluated by CCK-8, EdU, colony formation and flow cytometric assays, respectively. Meanwhile, the dual-luciferase reporter assay was used to investigate the interaction of miR-769-5p and lysine methyltransferase 2A (KMT2A) in glioma.Results: We foun

Published
2019

29. Association Between Blood-Brain Barrier Disruption and Stroke-Associated Pneumonia in Acute Ischemic Stroke Patients After Endovascular Therapy: A Retrospective Cohort Study.

Author

Ma H, Chen R, Han N, Ge H, Li S, Wang Y, Yan X, Du C, Gao Y, Zhang G, and Chang M

Subjects
Humans, Retrospective Studies, Male, Female, Aged, Middle Aged, Risk Factors, Logistic Models, Aged, 80 and over, Blood-Brain Barrier, Ischemic Stroke, Endovascular Procedures, Pneumonia
Abstract

Background: Stroke, particularly due to large vessel occlusion (LVO), is a major cause of mortality and disability globally. Endovascular therapy (ET) significantly improves outcomes for acute ischemic stroke (AIS) patients, but complications such as stroke-associated pneumonia (SAP) increase mortality and healthcare costs. This study investigates the association between blood-brain barrier (BBB) disruption and the increased risk of SAP and explores the relationship between BBB disruption and medium-term functional outcomes., Methods: The retrospective cohort study was performed on AIS patients enrolled between January 2019 to February 2023 who underwent ET. Patients were divided into two groups: BBB disruption and without BBB disruption. Multiple logistic regression model was conducted to measure the association between BBB disruption and SAP. Mediation analysis was used to estimate the potential mediation effects on the associations of BBB disruption with SAP. A restricted cubic spline (RCS) regression model was used to further outline the connection between the highest CT value of hyperattenuated lesions areas and the risk of SAP., Results: The study included 254 patients who underwent endovascular therapy, with 155 patients in the BBB disruption group (exposure) and 99 patients in the without BBB disruption group (control). Multiple logistic regression analysis revealed a significantly increased risk of SAP in patients with BBB disruption (OR = 2.337, 95% CI: 1.118-4.990, p = 0.025). Furthermore, mediation analysis suggested that this association may be partly due to malignant cerebral oedema and haemorrhagic transformation. The study found an inverse L-shaped dose-response relationship between the maximum CT values of BBB disruption areas and the incidence of SAP. SAP partially mediated the association between BBB disruption and 3-month poor functional outcome., Conclusion: BBB disruption are a potential risk factor for SAP. BBB disruption may affect short- and medium-term prognosis of patients after ET in part through SAP., Competing Interests: All the authors have no competing interests., (© 2024 Ma et al.)

Published
2024
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30. Effect of Intravenous Tirofiban vs Placebo Before Endovascular Thrombectomy on Functional Outcomes in Large Vessel Occlusion Stroke: The RESCUE BT Randomized Clinical Trial.

Author

Qiu Z, Li F, Sang H, Luo W, Liu S, Liu W, Guo Z, Li H, Sun D, Huang W, Zhang M, Zhang M, Dai W, Zhou P, Deng W, Zhou Z, Huang X, Lei B, Li J, Yuan Z, Song B, Miao J, Liu S, Jin Z, Zeng G, Zeng H, Yuan J, Wen C, Yu Y, Yuan G, Wu J, Long C, Luo J, Tian Z, Zheng C, Hu Z, Wang S, Wang T, Qi L, Li R, Wan Y, Ke Y, Wu Y, Zhu X, Kong W, Huang J, Peng D, Chang M, Ge H, Shi Z, Yan Z, Du J, Jin Y, Ju D, Huang C, Hong Y, Liu T, Zhao W, Wang J, Zheng B, Wang L, Liu S, Luo X, Luo S, Xu X, Hu J, Pu J, Chen S, Sun Y, Jiang S, Wei L, Fu X, Bai Y, Yang S, Hu W, Zhang G, Pan C, Zhang S, Wang Y, Cao W, Yang S, Zhang J, Guo F, Wen H, Zhang J, Song J, Yue C, Li L, Wu D, Tian Y, Yang J, Lu M, Saver JL, Nogueira RG, Zi W, and Yang Q

Subjects
Administration, Intravenous, Aged, Arterial Occlusive Diseases complications, Arterial Occlusive Diseases drug therapy, Arterial Occlusive Diseases surgery, Brain Ischemia drug therapy, Brain Ischemia etiology, Brain Ischemia surgery, Double-Blind Method, Female, Humans, Intracranial Hemorrhages chemically induced, Male, Stroke drug therapy, Stroke etiology, Stroke surgery, Treatment Outcome, Endovascular Procedures methods, Ischemic Stroke drug therapy, Ischemic Stroke etiology, Ischemic Stroke surgery, Platelet Aggregation Inhibitors administration & dosage, Platelet Aggregation Inhibitors adverse effects, Platelet Aggregation Inhibitors therapeutic use, Thrombectomy methods, Tirofiban administration & dosage, Tirofiban adverse effects, Tirofiban therapeutic use
Abstract

Importance: Tirofiban is a highly selective nonpeptide antagonist of glycoprotein IIb/IIIa receptor, which reversibly inhibits platelet aggregation. It remains uncertain whether intravenous tirofiban is effective to improve functional outcomes for patients with large vessel occlusion ischemic stroke undergoing endovascular thrombectomy., Objective: To assess the efficacy and adverse events of intravenous tirofiban before endovascular thrombectomy for acute ischemic stroke secondary to large vessel occlusion., Design, Setting, and Participants: This investigator-initiated, randomized, double-blind, placebo-controlled trial was implemented at 55 hospitals in China, enrolling 948 patients with stroke and proximal intracranial large vessel occlusion presenting within 24 hours of time last known well. Recruitment took place between October 10, 2018, and October 31, 2021, with final follow-up on January 15, 2022., Interventions: Participants received intravenous tirofiban (n = 463) or placebo (n = 485) prior to endovascular thrombectomy., Main Outcomes and Measures: The primary outcome was disability level at 90 days as measured by overall distribution of the modified Rankin Scale scores from 0 (no symptoms) to 6 (death). The primary safety outcome was the incidence of symptomatic intracranial hemorrhage within 48 hours., Results: Among 948 patients randomized (mean age, 67 years; 391 [41.2%] women), 948 (100%) completed the trial. The median (IQR) 90-day modified Rankin Scale score in the tirofiban group vs placebo group was 3 (1-4) vs 3 (1-4). The adjusted common odds ratio for a lower level of disability with tirofiban vs placebo was 1.08 (95% CI, 0.86-1.36). Incidence of symptomatic intracranial hemorrhage was 9.7% in the tirofiban group vs 6.4% in the placebo group (difference, 3.3% [95% CI, -0.2% to 6.8%])., Conclusions and Relevance: Among patients with large vessel occlusion acute ischemic stroke undergoing endovascular thrombectomy, treatment with intravenous tirofiban, compared with placebo, before endovascular therapy resulted in no significant difference in disability severity at 90 days. The findings do not support use of intravenous tirofiban before endovascular thrombectomy for acute ischemic stroke., Trial Registration: Chinese Clinical Trial Registry Identifier: ChiCTR-IOR-17014167.

Published
2022
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31. Protective effects of ginsenoside Rb1 on H 2 O 2 -induced oxidative injury in human endothelial cell line (EA.hy926) via miR-210.

Author

Jia F, Mou L, and Ge H

Subjects
Apoptosis drug effects, Cell Line, Cell Movement drug effects, Cell Survival drug effects, Endothelial Cells, Humans, Membrane Proteins metabolism, NF-kappa B metabolism, Reactive Oxygen Species metabolism, TOR Serine-Threonine Kinases metabolism, Ginsenosides pharmacology, Hydrogen Peroxide pharmacology, MicroRNAs metabolism, Oxidative Stress drug effects, Protective Agents pharmacology
Abstract

Ginsenoside Rb1 (Rb1) possesses a cardioprotective effect via mediating microRNAs (miRs), while it is unexplored whether miR-210 is regulated by Rb1 in response to oxidative stress. Human endothelial EA.hy926 cells were stimulated with H 2 O 2 before Rb1 treatment. After transfection, cell viability, apoptosis, migration, and invasion assays were conducted. Western blot was applied to quantify protein. BCL2/adenovirus E1B 19-kDa interacting protein 3 (BNIP3) and miR-210 were analyzed with quantitative reverse transcription polymerase chain reaction. Dual luciferase activity assay was performed. Rb1 elevated viability, migration, and invasion of H 2 O 2 -treated cells. H 2 O 2 -induced apoptosis was moderated by Rb1. miR-210 was augmented in H 2 O 2 -treated cells after Rb1 stimulation. miR-210 inhibitor abolished the positive effects of Rb1. BNIP3 was negatively modulated by miR-210 and implicated in modulating viability, apoptosis, and migration and invasion. In addition, BNIP3 modulated phosphorylation of regulators. Rb1 repressed oxidative injury via elevating miR-210. miR-210 negatively mediated BNIP3, which participated in oxidative damage via regulating mammalian targets of rapamycin (mTOR) and nuclear factor-κB (NF-κB).

Published
2019
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