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2 results on '"GeNeSIS National Board on behalf of the GeNeSIS Italian Investigators"'

1. Efficacy and safety of growth hormone treatment in children with short stature: the Italian cohort of the GeNeSIS clinical study

Author

Cappa, M., Iughetti, L., Loche, S., Maghnie, M., Vottero, A., Antoniazzi, Franco, Beccaria, Luciano, Bernasconi, Sergio, Caggiano, Domenico, Caruso-Nicoletti, Manuela, Catucci, Alessandra, Chiarelli, Francesco, Cianfarani, Stefano, Colucci, Anna Rita, De Rienzo, Francesca, Di Pumpo, Raffaele, Di Stasio, Alessandra, Farello, Giovanni, Felici, Leonardo, Femiano, Pasquale, Garagantini, Luigi, Giavoli, Claudia, Greggio, Nella Augusta, Guazzarotti, Laura, Larizza, Daniela, Licenziati, Maria Rosaria, Lonero, Antonella, Maggio, Maria Cristina, Marsciani, Alberto, Matarazzo, Patrizia, Mazzanti, Laura, Messini, Beatrice, Napoli, Flavia, Pasquino, Anna Maria, Perrone, Laura, Pilia, Sabrina, Pilotta, Alba, Piran, Marzia, Pozzobon, Gabriella, Predieri, Barbara, Sacco, Michele, Salerno, Mariacarolina, Tirendi, Antonina, Ubertini, Graziamaria, Vannelli, Silvia, Wasniewska, Malgorzata, Zampolli, Maria, Zanotti, Martina, Zuccotti, Gianvincenzo, and GeNeSIS National Board on behalf of the GeNeSIS Italian Investigators

Published
2016
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2. Efficacy and safety of growth hormone treatment in children with short stature: the Italian cohort of the GeNeSIS clinical study

Author

Cappa, M., Iughetti, L., Loche, S., Maghnie, M., Vottero, A, GeNeSIS National Board on behalf of the GeNeSIS Italian Investigators, Franco, Antoniazzi, Luciano, Beccaria, Sergio, Bernasconi, Domenico, Caggiano, Manuela, Caruso-Nicoletti, Alessandra, Catucci, Francesco, Chiarelli, Stefano, Cianfarani, Annarita, Colucci, Francesca De Rienzo, Raffaele Di Pumpo, Alessandra Di Stasio, Giovanni, Farello, Leonardo, Felici, Pasquale, Femiano, Luigi, Garagantini, Claudia, Giavoli, Nellaaugusta, Greggio, Laura, Guazzarotti, Daniela, Larizza, Mariarosaria, Licenziati, Antonella, Lonero, Mariacristina, Maggio, Alberto, Marsciani, Patrizia, Matarazzo, Laura, Mazzanti, Beatrice, Messini, Flavia, Napoli, Annamaria, Pasquino, Laura, Perrone, Sabrina, Pilia, Alba, Pilotta, Marzia, Piran, Gabriella, Pozzobon, Predieri, Barbara, Michele, Sacco, Mariacarolina, Salerno, Antonina, Tirendi, Graziamaria, Ubertini, Silvia, Vannelli, Malgorzata, Wasniewska, Maria, Zampolli, Martina, Zanotti, Gianvincenzo, Zuccotti, Cappa, M., Iughetti, L., Loche, S., Maghnie, M., Vottero, A, Salerno, Mariacarolina, Vottero, A.* Antoniazzi F, Beccaria L, Bernasconi S, Caggiano D, Caruso-Nicoletti M, Catucci A, Chiarelli F, Cianfarani S, Colucci AR, De Rienzo F, Di Pumpo R, Di Stasio A, Farello G, Felici L, Femiano P, Garagantini L, Giavoli C, Greggio NA, Guazzarotti L, Larizza D, Licenziati MR, Lonero A, Maggio MC, Marsciani A, Matarazzo P, Mazzanti L, Messini B, Napoli F, Pasquino AM, Perrone L, Pilia S, Pilotta A, Piran M, Pozzobon G, Predieri B, Sacco M, Salerno M, Tirendi A, Ubertini G, Vannelli S, Wasniewska M, Zampolli M, Zanotti M, Zuccotti G, Vottero, A., and Perrone, Laura

Subjects
Male, Pediatrics, Endocrinology, Diabetes and Metabolism, Turner Syndrome, Pediatric GH treatment, Growth, Clinical study, 0302 clinical medicine, Endocrinology, Turner syndrome, 030212 general & internal medicine, Prospective Studies, Prospective cohort study, Child, Final height, Safety, Short stature, Human Growth Hormone, Diabetes and Metabolism, Growth hormone treatment, Treatment Outcome, Italy, Child, Preschool, Cohort, Original Article, Female, Patient Safety, medicine.symptom, Human, medicine.medical_specialty, Adolescent, 030209 endocrinology & metabolism, Dwarfism, Neuroendocrinology, Body Height, Dwarfism, Pituitary, Humans, 03 medical and health sciences, medicine, Preschool, business.industry, medicine.disease, Prospective Studie, Pituitary, Observational study, Final height, Growth, Pediatric GH treatment, Safety, Short stature, Endocrinology, Diabetes and Metabolism, Endocrinology, business
Abstract

Purpose: We examined auxological changes in growth hormone (GH)-treated children in Italy using data from the Italian cohort of the multinational observational Genetics and Neuroendocrinology of Short Stature International Study (GeNeSIS) of pediatric patients requiring GH treatment. Methods: We studied 711 children (median baseline age 9.6 years). Diagnosis associated with short stature was as determined by the investigator. Height standard deviation score (SDS) was evaluated yearly until final or near-final height (n = 78). Adverse events were assessed in all GH-treated patients. Results: The diagnosis resulting in GH treatment was GH deficiency (GHD) in 85.5 % of patients, followed by Turner syndrome (TS 6.6 %). Median starting GH dose was higher in patients with TS (0.30 mg/kg/week) than patients with GHD (0.23 mg/kg/week). Median (interquartile range) GH treatment duration was 2.6 (0.6–3.7) years. Mean (95 % confidence interval) final height SDS gain was 2.00 (1.27–2.73) for patients with organic GHD (n = 18) and 1.19 (0.97–1.40) for patients with idiopathic GHD (n = 41), but lower for patients with TS, 0.37 (−0.03 to 0.77, n = 13). Final height SDS was >−2 for 94 % of organic GHD, 88 % of idiopathic GHD and 62 % of TS patients. Mean age at GH start was lower for organic GHD patients, and treatment duration was longer than for other groups, resulting in greater mean final height gain. GH-related adverse events occurred mainly in patients diagnosed with idiopathic GHD. Conclusions: Data from the Italian cohort of GeNeSIS showed auxological changes and safety of GH therapy consistent with results from international surveillance databases.

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