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1. Los profesionales de la salud y las consecuencias de una posible guerra en Irak: carta abierta al presidente del gobierno español

Author

Marrugat Jaume, Porta Miquel, Fernández Esteve, Pérez Gloria, Elosua Roberto, Plasencia Antonio, Pollán Marina, Espinás Josep Alfons, González Carlos Alberto, Ribas Núria, Pérez Sandra, Zock Jan Paul, Callizo Esther, Castaño Gemma, Domingo Antonia, García Judith, Santed Rosalía, Ballester Ferran, Puidollers Elisabet, Peiró Salvador, Pont Angels, Alvarez-Dardet Carlos, Luquin Elisabet, Tormo María José, Vall Oriol, Hervada Xurxo, Brugal Teresa, Manzanera Rafael, Roca Josep, González Luís Carlos, Vioque Jesús, Pérez Santiago, Castellsagué Xavier, Schiaffino Anna, Durán Enric, Berra Silvina, Macià Francesc, Rebagliato Marisa, Rajmil Luís, Peris Mercè, Vergara Montserrat, Sala Maria, Ribalta Alba, Gea Joaquim, Segura Andreu, Medina Mercè, Jansà Josep Maria, Hernández Ildefonso, Covas María Isabel, Fusté Josep, Benach Joan, Albertí Constança, Bosch Fèlix, Marín Dolors, Cucó Gemma, Rohlfs Izabella, Godoy Pere, Cabezas Carmen, Pérez Catherine, Serra Lluís, López Celsa, Ariza Carlos, Pérez Beatriz, Zurriaga Oscar, del Amo Julia, Llop Esther, Rodés Anna, Ortuño Jordi, Montes Agustín, Artundo Carlos, Pasarín María Isabel, Cano Rosa, Bellido Juan, Abraira Víctor, López-Abente Gonzalo, de la Cámara Agustín Gómez, Menoyo Esther, Galmés Antonia, Barrio Gregorio, Ferrer Montserrat, García Carmen, Gutierrez Gonzalo, Álvarez Ana, Fernández Karoline, Criado Juan José, Rabanaque María José, Martínez Pablo, Saracci Rodolfo, Manresa Josep Maria, Rosell Ignacio, Aibar Carlos, Martínez Juan, Navarro Carmen, García Rocío, Arocha José Luís, Vázquez Teresa, Sala Joan, Masiá Rafael, Sentí Mariano, Fitó Montserrat, Ferrer Yolanda, and Lown Bernard

Subjects
Public aspects of medicine, RA1-1270
Published
2003

2. Factors affecting the relationship between psychological status and quality of life in COPD patients

Author

Serra Ignasi, Ferrer Jaume, Gea Joaquim, Balcells Eva, Orozco-Levi Mauricio, de Batlle Jordi, Rodriguez Esther, Benet Marta, Donaire-González David, Antó Josep M, and Garcia-Aymerich Judith

Subjects
Computer applications to medicine. Medical informatics, R858-859.7
Abstract

Abstract Background This study aims to (i) evaluate the association between anxiety and depressive symptoms and health-related quality of life (HRQoL); and (ii) identify the effect modifiers of this relationship in patients with chronic obstructive pulmonary disease (COPD). Methods A total of 337 clinically stable COPD patients answered the St. George's Respiratory Questionnaire (SGRQ) (assessing HRQoL) and the Hospital Anxiety and Depression Scale (HADS). Socio-demographic information, lung function, and other clinical data were collected. Results Most patients (93%) were male; they had a mean (SD) age of 68 (9) years and mild to very severe COPD (post-bronchodilator FEV1 52 (16)% predicted). Multivariate analyses showed that anxiety, depression, or both conditions were associated with poor HRQoL (for all SGRQ domains). The association between anxiety and total HRQoL score was 6.7 points higher (indicating a worse HRQoL) in current workers than in retired individuals. Estimates for patients with "both anxiety and depression" were 5.8 points lower in stage I-II than in stage III-IV COPD, and 10.2 points higher in patients with other comorbidities than in those with only COPD. Conclusions This study shows a significant association between anxiety, depression, or both conditions and impaired HRQoL. Clinically relevant factors affecting the magnitude of this association include work status, COPD severity, and the presence of comorbidities.

Published
2010
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5. Bacterial Patterns and Empiric Antibiotic Use in COPD Patients With Community-Acquired Pneumonia

Author

Aruj, Patricia Karina, Attorri, Silvia, Barimboim, Enrique, Caeiro, Juan Pablo, Garzón, María I., Cambursano, Victor Hugo, Ceccato, Adrian, Chertcoff, Julio, Lascar, Florencia, Tulio, Fernando Di, Díaz, Ariel Cordon, Vedia, Lautaro de, Ganaha, Maria Cristina, Lambert, Sandra, Lopardo, Gustavo, Luna, Carlos M., Malberti, Alessio Gerardo, Morcillo, Nora, Tartara, Silvina, Pensotti, Claudia, Pereyra, Betiana, Scapellato, Pablo Gustavo, Stagnaro, Juan Pablo, Shah, Sonali, Lötsch, Felix, Thalhammer, Florian, Anseeuw, Kurt, Francois, Camille A., Braeckel, Eva Van, Vincent, Jean Louis, Djimon, Marcel Zannou, Bashi, Jules, Dodo, Roger, Nouér, Simone Aranha, Chipev, Peter, Encheva, Milena, Miteva, Darina, Petkova, Diana, Balkissou, Adamou Dodo, Pefura Yone, Eric Walter, Mbatchou Ngahane, Bertrand Hugo, Shen, Ning, Xu, Jin-fu, Bustamante Rico, Carlos Andres, Buitrago, Ricardo, Pereira Paternina, Fernando Jose, Kayembe Ntumba, Jean-Marie, Carevic, Vesna Vladic, Jakopovic, Marko, Jankovic, Mateja, Matkovic, Zinka, Mitrecic, Ivan, Bouchy Jacobsson, Marie-Laure, Christensen, Anette Bro, Bødtger, Uffe, Meyer, Christian Niels, Jensen, Andreas Vestergaard, Baunbæk-knudsen, Gertrud, Petersen, Pelle Trier, Andersen, Stine, Abd El-Wahhab, Ibrahim El-Said, Morsy, Nesreen Elsayed, Shafiek, Hanaa, Sobh, Eman, Abdulsemed, Kedir Abdella, Bertrand, Fabrice, Brun-Buisson, Christian, Montmollin, Etienne de, Fartoukh, Muriel, Messika, Jonathan, Tattevin, Pierre, Khoury, Abdo, Ebruke, Bernard, Dreher, Michael, Kolditz, Martin, Meisinger, Matthias, Pletz, Mathias W., Hagel, Stefan, Rupp, Jan, Schaberg, Tom, Spielmanns, Marc, Creutz, Petra, Suttorp, Norton, Siaw-Lartey, Beatrice, Dimakou, Katerina, Gaga, Mina, Papapetrou, Dimosthenis, Tsigou, Evdoxia, Ampazis, Dimitrios, Kaimakamis, Evangelos, Bhatia, Mohit, Dhar, Raja, D'Souza, George, Garg, Rajiv, Koul, Parvaiz A., Mahesh, P.A., Jayaraj, B.S., Narayan, Kiran Vishnu, Udnur, Hirennappa B., Krishnamurthy, Shashi Bhaskara, Kant, Surya, Swarnakar, Rajesh, Limaye, Sneha, Salvi, Sundeep, Golshani, Keihan, Keatings, Vera M., Martin-Loeches, Ignacio, Maor, Yasmin, Strahilevitz, Jacob, Battaglia, Salvatore, Carrabba, Maria, Ceriana, Piero, Confalonieri, Marco, Monforte, Antonella d’Arminio, Prato, Bruno Del, Rosa, Marino De, Fantini, Riccardo, Faverio, Paola, Fiorentino, Giuseppe, Gammino, Maria Antonia, Menzella, Francesco, Milani, Giuseppe, Nava, Stefano, Palmiero, Gerardo, Petrino, Roberta, Gabrielli, Barbara, Rossi, Paolo, Sorino, Claudio, Steinhilber, Gundi, Zanforlin, Alessandro, Franzetti, Fabio, Carugati, Manuela, Morosi, Manuela, Monge, Elisa, Carone, Mauro, Patella, Vincenzo, Scarlata, Simone, Comel, Andrea, Kurahashi, Kiyoyasu, Bacha, Zeina Aoun, Ugalde, Daniel Barajas, Zuñiga, Omar Ceballos, Villegas, José F., Medenica, Milic, Garde, E.M.W. van de, Mihsra, Deebya Raj, Shrestha, Poojan, Ridgeon, Elliott, Awokola, Babatunde Ishola, Nwankwo, Ogonna N.O., Olufunlola, Adefuye Bolanle, Olumide, Segaolu, Ukwaja, Kingsley N., Irfan, Muhammad, Minarowski, Lukasz, Szymon, Skoczyński, Froes, Felipe, Leuschner, Pedro, Meireles, Mariana, Ferrão, Cláudia, Neves, João, Ravara, Sofia B., Brocovschii, Victoria, Ion, Chesov, Rusu, Doina, Toma, Cristina, Chirita, Daniela, Dorobat, Carmen Mihaela, Birkun, Alexei, Kaluzhenina, Anna, Almotairi, Abdullah, Ali Bukhary, Zakeya Abdulbaqi, Edathodu, Jameela, Fathy, Amal, Abdulaziz Enani, Abdullah Mushira, Mohamed, Nazik Eltayeb, Memon, Jawed Ulhadi, Bella, Abdelhaleem, Bogdanović, Nada, Milenkovic, Branislava, Pesut, Dragica, Borderìas, Luis, Bordon Garcia, Noel Manuel, Alarcón, Hugo Cabello, Cilloniz, Catia, Torres, Antoni, Diaz-Brito, Vicens, Casas, Xavier, González, Alicia Encabo, Fernández-Almira, Maria Luisa, Gallego, Miguel, Gaspar-García, Inmaculada, Castillo, Juan González del, Victoria, Patricia Javaloyes, Martínez, Elena Laserna, Molina, Rosa Malo de, Marcos, Pedro J., Menéndez, Rosario, Pando-Sandoval, Ana, Aymerich, Cristina Prat, Torre, Alicia Lacoma de la, García-Olivé, Ignasi, Rello, Jordi, Moyano, Silvia, Sanz, Francisco, Sibila, Oriol, Rodrigo-Troyano, Ana, Solé-Violán, Jordi, Uranga, Ane, Boven, Job F.M. van, Torra, Ester Vendrell, Pujol, Jordi Almirall, Feldman, Charles, Yum, Ho Kee, Fiogbe, Arnauld Attannon, Yangui, Ferdaous, Bilaceroglu, Semra, Dalar, Levent, Yilmaz, Ufuk, Bogomolov, Artemii, Elahi, Naheed, Dhasmana, Devesh J., Feneley, Andrew, Ions, Rhiannon, Skeemer, Julie, Woltmann, Gerrit, Hancock, Carole, Hill, Adam T., Rudran, Banu, Ruiz-Buitrago, Silvia, Campbell, Marion, Whitaker, Paul, Youzguin, Alexander, Singanayagam, Anika, Allen, Karen S., Brito, Veronica, Dietz, Jessica, Dysart, Claire E., Kellie, Susan M., Franco-Sadud, Ricardo A., Meier, Garnet, Holland, Thomas L., Bergin, Stephen P., Kheir, Fayez, Landmeier, Mark, Lois, Manuel, Nair, Girish B., Patel, Hemali, Reyes, Katherine, Rodriguez-Cintron, William, Saito, Shigeki, Soni, Nilam J., Noda, Julio, Hinojosa, Cecilia I., Levine, Stephanie M., Angel, Luis F., Reyes, Luis F., Anzueto, Antonio, Whitlow, K. Scott, Hipskind, John, Sukhija, Kunal, Totten, Vicken, Wunderink, Richard G., Shah, Ray D., Mateyo, Kondwelani John, Noriega, Lorena, Alvarado, Ezequiel, Aman, Mohamed, Labra, Lucía, Pascual-Guardia, Sergi, Amati, Francesco, Marin-Corral, Judith, Aliberti, Stefano, Gea, Joaquim, Rodriguez, Alejandro, Sotgiu, Giovanni, Meyer, Christian N., Anzueto, Antonio R., and Restrepo, Marcos I.

Published
2023
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7. Predictors and changes of physical activity in idiopathic pulmonary fibrosis

Author

Badenes-Bonet, Diana, Rodó-Pin, Anna, Castillo-Villegas, Diego, Vicens-Zygmunt, Vanesa, Bermudo, Guadalupe, Hernández-González, Fernanda, Portillo, Karina, Martínez-Llorens, Juana, Chalela, Roberto, Caguana, Oswaldo, Sellarés, Jacobo, Molina-Molina, Maria, Duran, Xavier, Gea, Joaquim, Rodríguez-Chiaradia, Diego Agustín, and Balcells, Eva

Published
2022
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14. A Pilot Study on Proteomic Predictors of Mortality in Stable COPD.

Author

Enríquez-Rodríguez, Cesar Jessé, Casadevall, Carme, Faner, Rosa, Pascual-Guardia, Sergi, Castro-Acosta, Ady, López-Campos, José Luis, Peces-Barba, Germán, Seijo, Luis, Caguana-Vélez, Oswaldo Antonio, Monsó, Eduard, Rodríguez-Chiaradia, Diego, Barreiro, Esther, Cosío, Borja G., Agustí, Alvar, Gea, Joaquim, and Group, on behalf of the BIOMEPOC

Subjects
CHRONIC obstructive pulmonary disease, PEPTIDE mass fingerprinting, ARTIFICIAL intelligence, PROTEOMICS, DEATH forecasting
Abstract

Chronic Obstructive Pulmonary Disease (COPD) is the third leading cause of global mortality. Despite clinical predictors (age, severity, comorbidities, etc.) being established, proteomics offers comprehensive biological profiling to obtain deeper insights into COPD pathophysiology and survival prognoses. This pilot study aimed to identify proteomic footprints that could be potentially useful in predicting mortality in stable COPD patients. Plasma samples from 40 patients were subjected to both blind (liquid chromatography–mass spectrometry) and hypothesis-driven (multiplex immunoassays) proteomic analyses supported by artificial intelligence (AI) before a 4-year clinical follow-up. Among the 34 patients whose survival status was confirmed (mean age 69 ± 9 years, 29.5% women, FEV1 42 ± 15.3% ref.), 32% were dead in the fourth year. The analysis identified 363 proteins/peptides, with 31 showing significant differences between the survivors and non-survivors. These proteins predominantly belonged to different aspects of the immune response (12 proteins), hemostasis (9), and proinflammatory cytokines (5). The predictive modeling achieved excellent accuracy for mortality (90%) but a weaker performance for days of survival (Q2 0.18), improving mildly with AI-mediated blind selection of proteins (accuracy of 95%, Q2 of 0.52). Further stratification by protein groups highlighted the predictive value for mortality of either hemostasis or pro-inflammatory markers alone (accuracies of 95 and 89%, respectively). Therefore, stable COPD patients' proteomic footprints can effectively forecast 4-year mortality, emphasizing the role of inflammatory, immune, and cardiovascular events. Future applications may enhance the prognostic precision and guide preventive interventions. [ABSTRACT FROM AUTHOR]

Published
2024
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15. Relationship between Respiratory Microbiome and Systemic Inflammatory Markers in COPD: A Pilot Study.

Author

Casadevall, Carme, Quero, Sara, Millares, Laura, Faner, Rosa, Cosío, Borja G., Peces-Barba, Germán, Castro-Acosta, Ady, Montón, Concepción, Palou, Alexandre, Pascual-Guardia, Sergi, Agustí, Alvar, Gea, Joaquim, and Monsó, Eduard

Subjects
RESPIRATORY obstructions, RANK correlation (Statistics), CHRONIC obstructive pulmonary disease, EOSINOPHILS, SPUTUM, EOSINOPHILIA
Abstract

The respiratory microbiome may influence the development and progression of COPD by modulating local immune and inflammatory events. We aimed to investigate whether relative changes in respiratory bacterial abundance are also associated with systemic inflammation, and explore their relationship with the main clinical COPD phenotypes. Multiplex analysis of inflammatory markers and transcript eosinophil-related markers were analyzed on peripheral blood in a cohort of stable COPD patients (n = 72). Respiratory microbiome composition was analyzed by 16S rRNA microbial sequencing on spontaneous sputum. Spearman correlations were applied to test the relationship between the microbiome composition and systemic inflammation. The concentration of the plasma IL-8 showed an inverted correlation with the relative abundance of 17 bacterial genera in the whole COPD cohort. COPD patients categorized as eosinophilic showed positive relationships with blood eosinophil markers and inversely correlated with the degree of airway obstruction and the number of exacerbations during the previous year. COPD patients categorized as frequent exacerbators were enriched with the bacterial genera Pseudomonas which, in turn, was positively associated with the severity of airflow limitation and the prior year's exacerbation history. The associative relationships of the sputum microbiome with the severity of the disease emphasize the relevance of the interaction between the respiratory microbiota and systemic inflammation. [ABSTRACT FROM AUTHOR]

Published
2024
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17. COPD: systemic proteomic profiles in frequent and infrequent exacerbators

Author

Enríquez-Rodríguez, Cesar Jessé, primary, Casadevall, Carme, additional, Faner, Rosa, additional, Castro-Costa, Ady, additional, Pascual-Guàrdia, Sergi, additional, Seijó, Luis, additional, López-Campos, José Luis, additional, Peces-Barba, Germán, additional, Monsó, Eduard, additional, Barreiro, Esther, additional, Cosío, Borja G., additional, Agustí, Alvar, additional, and Gea, Joaquim, additional

Published
2024
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19. The BIOMEPOC Project: Personalized Biomarkers and Clinical Profiles in Chronic Obstructive Pulmonary Disease

Author

Gea, Joaquim, Pascual, Sergi, Castro-Acosta, Ady, Hernández-Carcereny, Carmen, Castelo, Robert, Márquez-Martín, Eduardo, Montón, Concepción, Palou, Alexandre, Faner, Rosa, Furlong, Laura I., Seijo, Luis, Sanz, Ferran, Torà, Montserrat, Vilaplana, Carles, Casadevall, Carme, López-Campos, José Luis, Monsó, Eduard, Peces-Barba, Germán, Cosío, Borja G., Agustí, Alvar, Admetlló, Mireia, Alvarez-Martínez, Carlos, Barreiro, Esther, Casals, Ferran, Córdova, Rocío, García, Marian, González-García, José G., Márquez, Eduardo, Ormaza, Miren Josune, Puigdevall, Pau, Seijó, Luis, and Torralba, Yolanda

Published
2019
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20. Proyecto de biomarcadores y perfiles clínicos personalizados en la enfermedad pulmonar obstructiva crónica (proyecto BIOMEPOC)

Author

Admetlló, Mireia, Agustí, Alvar, Alvarez-Martínez, Carlos, Barreiro, Esther, Casadevall, Carme, Casals, Ferran, Castelo, Robert, Castro-Acosta, Ady, Córdova, Rocío, Cosío, Borja G., Faner, Rosa, Furlong, Laura I., García, Marian, Gea, Joaquim, González-García, José G., Hernández-Carcereny, Carmen, López-Campos, José Luis, Márquez, Eduardo, Monsó, Eduard, Montón, Concepción, Ormaza, Miren Josune, Palou, Alexandre, Pascual, Sergi, Peces-Barba, Germán, Puigdevall, Pau, Sanz, Ferran, Seijó, Luis, Torà, Montserrat, Torralba, Yolanda, Vilaplana, Carles, Márquez-Martín, Eduardo, and Seijo, Luis

Published
2019
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21. An Official American Thoracic Society/European Respiratory Society Statement: Update on Limb Muscle Dysfunction in Chronic Obstructive Pulmonary Disease

Author

Maltais, François, Decramer, Marc, Casaburi, Richard, Barreiro, Esther, Burelle, Yan, Debigaré, Richard, Dekhuijzen, PN Richard, Franssen, Frits, Gayan-Ramirez, Ghislaine, Gea, Joaquim, Gosker, Harry R, Gosselink, Rik, Hayot, Maurice, Hussain, Sabah NA, Janssens, Wim, Polkey, Micheal I, Roca, Josep, Saey, Didier, Schols, Annemie MWJ, Spruit, Martijn A, Steiner, Michael, Taivassalo, Tanja, Troosters, Thierry, Vogiatzis, Ioannis, and Wagner, Peter D

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Rehabilitation, Physical Rehabilitation, Chronic Obstructive Pulmonary Disease, Lung, Aetiology, Evaluation of treatments and therapeutic interventions, 2.1 Biological and endogenous factors, 6.7 Physical, Respiratory, Musculoskeletal, Good Health and Well Being, Comorbidity, Databases, Bibliographic, Disease Progression, Exercise Therapy, Exercise Tolerance, Extremities, Humans, Hypoxia, Muscle, Skeletal, Obesity, Oxidative Stress, Pulmonary Disease, Chronic Obstructive, Societies, Medical, United States, Vitamin D Deficiency, ATS/ERS Ad Hoc Committee on Limb Muscle Dysfunction in COPD, Medical and Health Sciences, Respiratory System, Cardiovascular medicine and haematology, Clinical sciences
Abstract

BackgroundLimb muscle dysfunction is prevalent in chronic obstructive pulmonary disease (COPD) and it has important clinical implications, such as reduced exercise tolerance, quality of life, and even survival. Since the previous American Thoracic Society/European Respiratory Society (ATS/ERS) statement on limb muscle dysfunction, important progress has been made on the characterization of this problem and on our understanding of its pathophysiology and clinical implications.PurposeThe purpose of this document is to update the 1999 ATS/ERS statement on limb muscle dysfunction in COPD.MethodsAn interdisciplinary committee of experts from the ATS and ERS Pulmonary Rehabilitation and Clinical Problems assemblies determined that the scope of this document should be limited to limb muscles. Committee members conducted focused reviews of the literature on several topics. A librarian also performed a literature search. An ATS methodologist provided advice to the committee, ensuring that the methodological approach was consistent with ATS standards.ResultsWe identified important advances in our understanding of the extent and nature of the structural alterations in limb muscles in patients with COPD. Since the last update, landmark studies were published on the mechanisms of development of limb muscle dysfunction in COPD and on the treatment of this condition. We now have a better understanding of the clinical implications of limb muscle dysfunction. Although exercise training is the most potent intervention to address this condition, other therapies, such as neuromuscular electrical stimulation, are emerging. Assessment of limb muscle function can identify patients who are at increased risk of poor clinical outcomes, such as exercise intolerance and premature mortality.ConclusionsLimb muscle dysfunction is a key systemic consequence of COPD. However, there are still important gaps in our knowledge about the mechanisms of development of this problem. Strategies for early detection and specific treatments for this condition are also needed.

Published
2014

22. Proteomic Blood Profiles Obtained by Totally Blind Biological Clustering in Stable and Exacerbated COPD Patients.

Author

Enríquez-Rodríguez, Cesar Jessé, Pascual-Guardia, Sergi, Casadevall, Carme, Caguana-Vélez, Oswaldo Antonio, Rodríguez-Chiaradia, Diego, Barreiro, Esther, and Gea, Joaquim

Subjects
CHRONIC obstructive pulmonary disease, TANDEM mass spectrometry, CLINICAL medicine research, PROTEOMICS, HUMORAL immunity
Abstract

Although Chronic Obstructive Pulmonary Disease (COPD) is highly prevalent, it is often underdiagnosed. One of the main characteristics of this heterogeneous disease is the presence of periods of acute clinical impairment (exacerbations). Obtaining blood biomarkers for either COPD as a chronic entity or its exacerbations (AECOPD) will be particularly useful for the clinical management of patients. However, most of the earlier studies have been characterized by potential biases derived from pre-existing hypotheses in one or more of their analysis steps: some studies have only targeted molecules already suggested by pre-existing knowledge, and others had initially carried out a blind search but later compared the detected biomarkers among well-predefined clinical groups. We hypothesized that a clinically blind cluster analysis on the results of a non-hypothesis-driven wide proteomic search would determine an unbiased grouping of patients, potentially reflecting their endotypes and/or clinical characteristics. To check this hypothesis, we included the plasma samples from 24 clinically stable COPD patients, 10 additional patients with AECOPD, and 10 healthy controls. The samples were analyzed through label-free liquid chromatography/tandem mass spectrometry. Subsequently, the Scikit-learn machine learning module and K-means were used for clustering the individuals based solely on their proteomic profiles. The obtained clusters were confronted with clinical groups only at the end of the entire procedure. Although our clusters were unable to differentiate stable COPD patients from healthy individuals, they segregated those patients with AECOPD from the patients in stable conditions (sensitivity 80%, specificity 79%, and global accuracy, 79.4%). Moreover, the proteins involved in the blind grouping process to identify AECOPD were associated with five biological processes: inflammation, humoral immune response, blood coagulation, modulation of lipid metabolism, and complement system pathways. Even though the present results merit an external validation, our results suggest that the present blinded approach may be useful to segregate AECOPD from stability in both the clinical setting and trials, favoring more personalized medicine and clinical research. [ABSTRACT FROM AUTHOR]

Published
2024
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25. Physical activity measurement with questionnaire in idiopathic pulmonary fibrosis

Author

Badenes Bonet, Diana, primary, Hurley, Patrick, additional, Rodó-Pin, Anna, additional, Castillo-Villegas, Diego, additional, Vicens-Zygmunt, Vanesa, additional, Bermudo, Guadalupe, additional, Hernández-González, Fernanda, additional, Portillo, Karina, additional, Martínez-Llorens, Juana, additional, Herranz, Anna, additional, Chalela, Roberto, additional, Sellarés, Jacobo, additional, Molina-Molina, Maria, additional, Duran, Xavier, additional, Gea, Joaquim, additional, Rodríguez-Chiaradia, Diego, additional, and Balcells, Eva, additional

Published
2023
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30. Effect of blood glucose level on standardized uptake value (SUV) in 18F- FDG PET-scan: a systematic review and meta-analysis of 20,807 individual SUV measurements

Author

Eskian, Mahsa, Alavi, Abass, Khorasanizadeh, MirHojjat, Viglianti, Benjamin L., Jacobsson, Hans, Barwick, Tara D., Meysamie, Alipasha, Yi, Sun K., Iwano, Shingo, Bybel, Bohdan, Caobelli, Federico, Lococo, Filippo, Gea, Joaquim, Sancho-Muñoz, Antonio, Schildt, Jukka, Tatcı, Ebru, Lapa, Constantin, Keramida, Georgia, Peters, Michael, Boktor, Raef R., John, Joemon, Pitman, Alexander G., Mazurek, Tomasz, and Rezaei, Nima

Published
2019
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31. Treatment of COVID-19 during the Acute Phase in Hospitalized Patients Decreases Post-Acute Sequelae of COVID-19

Author

Badenes Bonet, Diana, primary, Caguana Vélez, Oswaldo Antonio, additional, Duran Jordà, Xavier, additional, Comas Serrano, Merce, additional, Posso Rivera, Margarita, additional, Admetlló, Mireia, additional, Herranz Blasco, Anna, additional, Cuadrado Godia, Elisa, additional, Marco Navarro, Ester, additional, Martin Ezquerra, Gemma, additional, Pineiro Aguin, Zenaida, additional, Cumpli Gargallo, Maria Cinta, additional, Gonzalez Garcia, Jose Gregorio, additional, Balcells Vilarnau, Eva, additional, Rodriguez Chiaradia, Diego, additional, Castells, Xavier, additional, Gea, Joaquim, additional, Horcajada, Juan P., additional, and Villar-García, Judit, additional

Published
2023
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34. Impacto a largo plazo del tratamiento con presión positiva continua en la vía aérea superior sobre la incidencia de arritmias y la variabilidad de frecuencia cardiaca en pacientes con apnea del sueño

Author

Grau, Nuria, Bazan, Victor, Kallouchi, Mohamed, Rodriguez, Diego, Estirado, Cristina, Corral, Maria Isabel, Valls, Maria Teresa, Ramos, Pablo, Sanjuas, Carles, Felez, Miquel, Valles, Ermengol, Benito, Begoña, Gea, Joaquim, Bruguera-Cortada, Jordi, and Martí-Almor, Julio

Published
2016
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36. Relationship between the respiratory microbiome and the severity of airflow limitation, history of exacerbations and circulating eosinophils in COPD patients

Author

Millares, Laura, Pascual, Sergi, Montón, Concepción, García-Núñez, Marian, Lalmolda, Cristina, Faner, Rosa, Casadevall, Carme, Setó, Laia, Capilla, Silvia, Moreno, Amàlia, Castro-Acosta, Ady Angélica, Alvarez-Martinez, Carlos José, Sibila, Oriol, Peces-Barba, Germán, Cosio, Borja G., Agustí, Alvar, Gea, Joaquim, and Monsó, Eduard

Published
2019
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37. Bacterial Patterns and Empiric Antibiotic Use in COPD Patients With Community-Acquired Pneumonia

Author

Pascual-Guardia, Sergi, Amati, Francesco, Marin-Corral, Judith, Aliberti, Stefano, Gea, Joaquim, Soni, Nilam J., Rodriguez, Alejandro, Sibila, Oriol, Sanz, Francisco, Sotgiu, Giovanni, Marcos, Pedro J., Uranga, Ane, Milenkovic, Branislava, Meyer, Christian N., Kolditz, Martin, Anzueto, Antonio R., Restrepo, Marcos I., Pascual-Guardia, Sergi, Amati, Francesco, Marin-Corral, Judith, Aliberti, Stefano, Gea, Joaquim, Soni, Nilam J., Rodriguez, Alejandro, Sibila, Oriol, Sanz, Francisco, Sotgiu, Giovanni, Marcos, Pedro J., Uranga, Ane, Milenkovic, Branislava, Meyer, Christian N., Kolditz, Martin, Anzueto, Antonio R., and Restrepo, Marcos I.

Abstract

Introduction: Chronic obstructive pulmonary disease (COPD) is strongly associated with the development of community-acquired pneumonia (CAP). Limited data are available on risk factors for difficult to manage bacteria such as Pseudomonas aeruginosa in COPD patients with CAP. Our objective was to assess the microbiological patterns associated with risk factors that determine empiric antibiotic therapy in hospitalized COPD patients with CAP. Methods: We performed a secondary data analysis of an international, multicenter, observational, point-prevalence study involving hospitalized COPD patients with CAP from March to June 2015. After identifying the risk factors associated with different microorganisms, we developed a scoring system to guide decision-making about empiric anti-pseudomonal antibiotic therapy in this population. Results: We enrolled 689 hospitalized COPD patients with CAP with documented microbiological testing. The most frequent microorganisms isolated were Streptococcus pneumoniae (8%) and Gram-negative bacteria (8%), P. aeruginosa (7%) and Haemophilus influenzae (3%). We developed a scoring system incorporating the variables independently associated with P. aeruginosa that include a previous P. aeruginosa isolation or infection (OR 14.2 [95%CI 5.7–35.2]), hospitalization in the past 12 months (OR 3.7 [1.5–9.2]), and bronchiectasis (OR 3.2 [1.4–7.2]). Empiric anti-pseudomonal antibiotics were overutilized in COPD patients with CAP. The new scoring system has the potential to reduce empiric anti-pseudomonal antibiotic use from 54.1% to 6.2%. Conclusions: COPD patients with CAP present different microbiological profiles associated with unique risk factors. Anti-pseudomonal treatment is a critical decision when selecting empiric antibiotic therapy. We developed a COPD scoring system to guide decision-making about empiric anti-pseudomonal antibiotic therapy.

Published
2023

39. Bacterial Patterns and Empiric Antibiotic Use in COPD Patients With Community-Acquired Pneumonia

Author

Pascual-Guardia, Sergi, primary, Amati, Francesco, additional, Marin-Corral, Judith, additional, Aliberti, Stefano, additional, Gea, Joaquim, additional, Soni, Nilam J., additional, Rodriguez, Alejandro, additional, Sibila, Oriol, additional, Sanz, Francisco, additional, Sotgiu, Giovanni, additional, Marcos, Pedro J., additional, Uranga, Ane, additional, Milenkovic, Branislava, additional, Meyer, Christian N., additional, Kolditz, Martin, additional, Anzueto, Antonio R., additional, and Restrepo, Marcos I., additional

Published
2023
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