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162 results on '"Gearhart, Debra"'

1. Trajectory of lobar atrophy in asymptomatic and symptomatic GRN mutation carriers: a longitudinal MRI study

Author

Chen, Qin, Boeve, Bradley F, Senjem, Matthew, Tosakulwong, Nirubol, Lesnick, Timothy, Brushaber, Danielle, Dheel, Christina, Fields, Julie, Forsberg, Leah, Gavrilova, Ralitza, Gearhart, Debra, Graff-Radford, Jonathan, Graff-Radford, Neill, Jack, Clifford R, Jones, David, Knopman, David, Kremers, Walter K, Lapid, Maria, Rademakers, Rosa, Ramos, Eliana Marisa, Syrjanen, Jeremy, Boxer, Adam L, Rosen, Howie, Wszolek, Zbigniew K, and Kantarci, Kejal

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Brain Disorders, Biomedical Imaging, Neurosciences, Alzheimer's Disease Related Dementias (ADRD), Aging, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Frontotemporal Dementia (FTD), Dementia, Acquired Cognitive Impairment, Neurodegenerative, Neurological, Adult, Asymptomatic Diseases, Atrophy, Female, Frontotemporal Lobar Degeneration, Heterozygote, Humans, Loss of Function Mutation, Magnetic Resonance Imaging, Male, Middle Aged, Progranulins, Temporal Lobe, Young Adult, Magnetic resonance image, GRN, Asymptomatic, Frontotemporal dementia, Longitudinal, Neurology & Neurosurgery, Biological psychology
Abstract

Loss-of-function mutations in the progranulin gene (GRN) are one of the major causes of familial frontotemporal lobar degeneration. Our objective was to determine the rates and trajectories of lobar cortical atrophy from longitudinal structural magnetic resonance imaging in both asymptomatic and symptomatic GRN mutation carriers. Individuals in this study were from the ADRC and LEFFTDS studies at the Mayo Clinic. We identified 13 GRN mutation carriers (8 asymptomatic, 5 symptomatic) and noncarriers (n = 10) who had at least 2 serial T1-weighted structural magnetic resonance images and were followed annually with a median of 3 years (range 1.0-9.8 years). Longitudinal changes in lobar cortical volume were analyzed using the tensor-based morphometry with symmetric normalization (TBM-SyN) algorithm. Linear mixed-effect models were used to model cortical volume change over time among 3 groups. The annual rates of frontal (p < 0.05) and parietal (p < 0.01) lobe cortical atrophy were higher in asymptomatic GRN mutation carriers than noncarriers. The symptomatic GRN mutation carriers also had increased rates of atrophy in the frontal (p < 0.01) and parietal lobe (p < 0.01) cortices than noncarriers. In addition, greater rates of cortical atrophy were observed in the temporal lobe cortices of symptomatic GRN mutation carriers than noncarriers (p < 0.001). We found that a decline in frontal and parietal lobar cortical volume occurs in asymptomatic GRN mutation carriers and continues in the symptomatic GRN mutation carriers, whereas an increased rate of temporal lobe cortical atrophy is observed only in symptomatic GRN mutation carriers. This sequential pattern of cortical involvement in GRN mutation carriers has important implications for using imaging biomarkers of neurodegeneration as an outcome measure in potential treatment trials involving GRN mutation carriers.

Published
2020

2. Clinical and volumetric changes with increasing functional impairment in familial frontotemporal lobar degeneration.

Author

Olney, Nicholas T, Ong, Elise, Goh, Sheng-Yang M, Bajorek, Lynn, Dever, Reilly, Staffaroni, Adam M, Cobigo, Yann, Bock, Meredith, Chiang, Kevin, Ljubenkov, Peter, Kornak, John, Heuer, Hilary W, Wang, Ping, Rascovsky, Katya, Wolf, Amelia, Appleby, Brian, Bove, Jessica, Bordelon, Yvette, Brannelly, Patrick, Brushaber, Danielle, Caso, Christine, Coppola, Giovanni, Dickerson, Bradford C, Dickinson, Susan, Domoto-Reilly, Kimiko, Faber, Kelly, Ferrall, Jessica, Fields, Julie, Fishman, Ann, Fong, Jamie, Foroud, Tatiana, Forsberg, Leah K, Gearhart, Debra J, Ghazanfari, Behnaz, Ghoshal, Nupur, Goldman, Jill, Graff-Radford, Jonathan, Graff-Radford, Neill R, Grant, Ian, Grossman, Murray, Haley, Dana, Hsiung, Gingyuek, Huey, Edward D, Irwin, David J, Jones, David T, Kantarci, Kejal, Karydas, Anna M, Kaufer, Daniel, Kerwin, Diana, Knopman, David S, Kramer, Joel H, Kraft, Ruth, Kremers, Walter, Kukull, Walter, Lapid, Maria I, Litvan, Irene, Mackenzie, Ian R, Maldonado, Miranda, Manoochehri, Masood, McGinnis, Scott M, McKinley, Emily C, Mendez, Mario F, Miller, Bruce L, Onyike, Chiadi, Pantelyat, Alex, Pearlman, Rodney, Petrucelli, Len, Potter, Madeleine, Rademakers, Rosa, Ramos, Eliana M, Rankin, Katherine P, Roberson, Erik D, Rogalski, Emily, Sengdy, Pheth, Shaw, Leslie M, Syrjanen, Jeremy, Tartaglia, M Carmela, Tatton, Nadine, Taylor, Joanne, Toga, Arthur, Trojanowski, John Q, Weintraub, Sandra, Wong, Bonnie, Wszolek, Zbigniew, Boxer, Adam L, Boeve, Brad F, Rosen, Howard J, and ARTFL and LEFFTDS consortia

Subjects
ARTFL and LEFFTDS consortia, Temporal Lobe, Humans, Atrophy, Genetic Predisposition to Disease, tau Proteins, Magnetic Resonance Imaging, Longitudinal Studies, Neuropsychological Tests, Image Processing, Computer-Assisted, Middle Aged, Female, Male, Frontotemporal Lobar Degeneration, C9orf72 Protein, Progranulins, C9ORF72, Familial, Frontotemporal lobar degeneration, GRN, Genetic, MAPT, Frontotemporalobar degeneration, Neurodegenerative, Behavioral and Social Science, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Alzheimer's Disease Related Dementias (ADRD), Biomedical Imaging, Aging, Alzheimer's Disease, Clinical Trials and Supportive Activities, Acquired Cognitive Impairment, Dementia, Clinical Research, Brain Disorders, Neurosciences, Rare Diseases, Frontotemporal Dementia (FTD), 2.1 Biological and endogenous factors, Neurological, Geriatrics, Clinical Sciences
Abstract

IntroductionThe Advancing Research and Treatment in Frontotemporal Lobar Degeneration and Longitudinal Evaluation of Familial Frontotemporal Dementia Subjects longitudinal studies were designed to describe the natural history of familial-frontotemporal lobar degeneration due to autosomal dominant mutations.MethodsWe examined cognitive performance, behavioral ratings, and brain volumes from the first time point in 320 MAPT, GRN, and C9orf72 family members, including 102 non-mutation carriers, 103 asymptomatic carriers, 43 mildly/questionably symptomatic carriers, and 72 carriers with dementia.ResultsAsymptomatic carriers showed similar scores on all clinical measures compared with noncarriers but reduced frontal and temporal volumes. Those with mild/questionable impairment showed decreased verbal recall, fluency, and Trail Making Test performance and impaired mood and self-monitoring. Dementia was associated with impairment in all measures. All MAPT carriers with dementia showed temporal atrophy, but otherwise, there was no single cognitive test or brain region that was abnormal in all subjects.DiscussionImaging changes appear to precede clinical changes in familial-frontotemporal lobar degeneration, but specific early clinical and imaging changes vary across individuals.

Published
2020

3. Individualized atrophy scores predict dementia onset in familial frontotemporal lobar degeneration.

Author

Staffaroni, Adam M, Cobigo, Yann, Goh, Sheng-Yang M, Kornak, John, Bajorek, Lynn, Chiang, Kevin, Appleby, Brian, Bove, Jessica, Bordelon, Yvette, Brannelly, Patrick, Brushaber, Danielle, Caso, Christina, Coppola, Giovanni, Dever, Reilly, Dheel, Christina, Dickerson, Bradford C, Dickinson, Susan, Dominguez, Sophia, Domoto-Reilly, Kimiko, Faber, Kelly, Ferrall, Jessica, Fields, Julie A, Fishman, Ann, Fong, Jamie, Foroud, Tatiana, Forsberg, Leah K, Gavrilova, Ralitza, Gearhart, Debra, Ghazanfari, Behnaz, Ghoshal, Nupur, Goldman, Jill, Graff-Radford, Jonathan, Graff-Radford, Neill, Grant, Ian, Grossman, Murray, Haley, Dana, Heuer, Hilary W, Hsiung, Ging-Yuek, Huey, Edward D, Irwin, David J, Jones, David T, Jones, Lynne, Kantarci, Kejal, Karydas, Anna, Kaufer, Daniel I, Kerwin, Diana R, Knopman, David S, Kraft, Ruth, Kramer, Joel H, Kremers, Walter K, Kukull, Walter A, Litvan, Irene, Ljubenkov, Peter A, Lucente, Diane, Lungu, Codrin, Mackenzie, Ian R, Maldonado, Miranda, Manoochehri, Masood, McGinnis, Scott M, McKinley, Emily, Mendez, Mario F, Miller, Bruce L, Multani, Namita, Onyike, Chiadi, Padmanabhan, Jaya, Pantelyat, Alex, Pearlman, Rodney, Petrucelli, Len, Potter, Madeline, Rademakers, Rosa, Ramos, Eliana Marisa, Rankin, Katherine P, Rascovsky, Katya, Roberson, Erik D, Rogalski, Emily, Sengdy, Pheth, Shaw, Leslie M, Syrjanen, Jeremy, Tartaglia, M Carmela, Tatton, Nadine, Taylor, Joanne, Toga, Arthur, Trojanowski, John Q, Weintraub, Sandra, Wang, Ping, Wong, Bonnie, Wszolek, Zbigniew, Boxer, Adam L, Boeve, Brad F, Rosen, Howard J, and ARTFL/LEFFTDS consortium

Subjects
ARTFL/LEFFTDS consortium, Brain, Humans, Atrophy, Genetic Predisposition to Disease, tau Proteins, Magnetic Resonance Imaging, Neuropsychological Tests, Mutation, Image Processing, Computer-Assisted, Middle Aged, Female, Male, Frontotemporal Dementia, C9orf72 Protein, Progranulins, Frontotemporal dementia, Genetics, Magnetic resonance imaging, TDP-43, Tau, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Frontotemporal Dementia (FTD), Dementia, Brain Disorders, Neurosciences, Acquired Cognitive Impairment, Prevention, Alzheimer's Disease, Rare Diseases, Aging, Neurodegenerative, Neurological, Geriatrics, Clinical Sciences
Abstract

IntroductionSome models of therapy for neurodegenerative diseases envision starting treatment before symptoms develop. Demonstrating that such treatments are effective requires accurate knowledge of when symptoms would have started without treatment. Familial frontotemporal lobar degeneration offers a unique opportunity to develop predictors of symptom onset.MethodsWe created dementia risk scores in 268 familial frontotemporal lobar degeneration family members by entering covariate-adjusted standardized estimates of brain atrophy into a logistic regression to classify asymptomatic versus demented participants. The score's predictive value was tested in a separate group who were followed up longitudinally (stable vs. converted to dementia) using Cox proportional regressions with dementia risk score as the predictor.ResultsCross-validated logistic regression achieved good separation of asymptomatic versus demented (accuracy = 90%, SE = 0.06). Atrophy scores predicted conversion from asymptomatic or mildly/questionably symptomatic to dementia (HR = 1.51, 95% CI: [1.16,1.98]).DiscussionIndividualized quantification of baseline brain atrophy is a promising predictor of progression in asymptomatic familial frontotemporal lobar degeneration mutation carriers.

Published
2020

4. The longitudinal evaluation of familial frontotemporal dementia subjects protocol: Framework and methodology

Author

Boeve, Bradley, Bove, Jessica, Brannelly, Patrick, Brushaber, Danielle, Coppola, Giovanni, Dever, Rielly, Dheel, Christina, Dickerson, Bradford, Dickinson, Susan, Faber, Kelley, Fields, Julie, Fong, Jamie, Foroud, Tatiana, Forsberg, Leah, Gavrilova, Ralitza, Gearhart, Debra, Ghoshal, Nupur, Goldman, Jennifer, Graff‐Radford, Jonathan, Graff‐Radford, Neill, Grossman, Murray, Haley, Dana, Heuer, Hilary, Hsiung, Ging‐Yuek Robin, Huey, Edward, Irwin, David, Jones, David, Jones, Lynne, Kantarci, Kejal, Karydas, Anna, Knopman, David, Kornak, John, Kraft, Ruth, Kramer, Joel, Kremers, Walter, Kukull, Walter, Lapid, Maria, Lucente, Diane, Mackenzie, Ian, Manoochehri, Masood, McGinnis, Scott, Miller, Bruce, Pearlman, Rodney, Petrucelli, Len, Potter, Madeline, Rademakers, Rosa, Ramos, Eliana Marisa, Rankin, Kate, Rascovsky, Katya, Sengdy, Pheth, Shaw, Les, Syrjanen, Jeremy, Tatton, Nadine, Taylor, Joanne, Toga, Arthur, Trojanowski, John, Weintraub, Sandra, Wong, Bonnie, Wszolek, Zbigniew, Boxer, Adam, Rosen, Howard, and Consortium, on Behalf of the LEFFTDS

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Clinical Research, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Alzheimer's Disease Related Dementias (ADRD), Neurosciences, Dementia, Brain Disorders, Rare Diseases, Alzheimer's Disease, Acquired Cognitive Impairment, Genetics, Aging, Neurodegenerative, Clinical Trials and Supportive Activities, Frontotemporal Dementia (FTD), Neurological, Adult, C9orf72 Protein, Female, Frontotemporal Dementia, Genetic Predisposition to Disease, Humans, Longitudinal Studies, Magnetic Resonance Imaging, Male, Middle Aged, Mutation, Neuropsychological Tests, tau Proteins, C9orf72, Frontotemporal dementia, GRN, MAPT, Tau, TDP-43, LEFFTDS Consortium, Geriatrics, Clinical sciences, Biological psychology
Abstract

IntroductionIt is important to establish the natural history of familial frontotemporal lobar degeneration (f-FTLD) and provide clinical and biomarker data for planning these studies, particularly in the asymptomatic phase.MethodsThe Longitudinal Evaluation of Familial Frontotemporal Dementia Subjects protocol was designed to enroll and follow at least 300 subjects for more than at least three annual visits who are members of kindreds with a mutation in one of the three most common f-FTLD genes-microtubule-associated protein tau, progranulin, or chromosome 9 open reading frame 72.ResultsWe present the theoretical considerations of f-FTLD and the aims/objectives of this protocol. We also describe the design and methodology for evaluating and rating subjects, in which detailed clinical and neuropsychological assessments are performed, biofluid samples are collected, and magnetic resonance imaging scans are performed using a standard protocol.DiscussionThese data and samples, which are available to interested investigators worldwide, will facilitate planning for upcoming disease-modifying therapeutic trials in f-FTLD.

Published
2020

5. Assessment of executive function declines in presymptomatic and mildly symptomatic familial frontotemporal dementia: NIH-EXAMINER as a potential clinical trial endpoint.

Author

Staffaroni, Adam M, Bajorek, Lynn, Casaletto, Kaitlin B, Cobigo, Yann, Goh, Sheng-Yang M, Wolf, Amy, Heuer, Hilary W, Elahi, Fanny M, Ljubenkov, Peter A, Dever, Reilly, Kornak, John, Appleby, Brian, Bove, Jessica, Bordelon, Yvette, Brannelly, Patrick, Brushaber, Danielle, Caso, Christina, Coppola, Giovanni, Dheel, Christina, Dickerson, Bradford C, Dickinson, Susan, Dominguez, Sophia, Domoto-Reilly, Kimiko, Faber, Kelly, Ferrall, Jessica, Fields, Julie A, Fishman, Ann, Fong, Jamie, Foroud, Tatiana, Forsberg, Leah K, Gavrilova, Ralitza, Gearhart, Debra, Ghazanfari, Behnaz, Ghoshal, Nupur, Goldman, Jill, Graff-Radford, Jonathan, Graff-Radford, Neill, Grant, Ian, Grossman, Murray, Haley, Dana, Hsiung, Ging-Yuek, Huey, Edward D, Irwin, David J, Jones, David T, Jones, Lynne, Kantarci, Kejal, Karydas, Anna, Kaufer, Daniel I, Kerwin, Diana R, Knopman, David S, Kraft, Ruth, Kremers, Walter K, Kukull, Walter A, Litvan, Irene, Lucente, Diane, Lungu, Codrin, Mackenzie, Ian R, Maldonado, Miranda, Manoochehri, Masood, McGinnis, Scott M, McKinley, Emily, Mendez, Mario F, Miller, Bruce L, Multani, Namita, Onyike, Chiadi, Padmanabhan, Jaya, Pantelyat, Alex, Pearlman, Rodney, Petrucelli, Len, Potter, Madeline, Rademakers, Rosa, Ramos, Eliana Marisa, Rankin, Katherine P, Rascovsky, Katya, Roberson, Erik D, Rogalski, Emily, Sengdy, Pheth, Shaw, Leslie M, Syrjanen, Jeremy, Tartaglia, M Carmela, Tatton, Nadine, Taylor, Joanne, Toga, Arthur, Trojanowski, John Q, Weintraub, Sandra, Wang, Ping, Wong, Bonnie, Wszolek, Zbigniew, Boxer, Adam L, Boeve, Brad F, Kramer, Joel H, Rosen, Howard J, and ARTFL/LEFFTDS consortium

Subjects
ARTFL/LEFFTDS consortium, Humans, Disease Progression, Magnetic Resonance Imaging, Longitudinal Studies, Neuropsychological Tests, Mutation, Middle Aged, Female, Male, Executive Function, Frontotemporal Dementia, Biomarkers, C9orf72 Protein, Behavioral variant, Cognition, Corticobasal syndrome, Fluency, Genetic, Inhibition, Neuropsychology, Nonfluent variant, Primary progressive aphasia, Progranulin, Progressive supranuclear palsy, Semantic variant, Set-shifting, Tau, Working memory, Clinical Sciences, Neurosciences, Geriatrics
Abstract

IntroductionIdentifying clinical measures that track disease in the earliest stages of frontotemporal lobar degeneration (FTLD) is important for clinical trials. Familial FTLD provides a unique paradigm to study early FTLD. Executive dysfunction is a clinically relevant hallmark of FTLD and may be a marker of disease progression.MethodsNinety-three mutation carriers with no symptoms or minimal/questionable symptoms (MAPT, n = 31; GRN, n = 28; C9orf72, n = 34; Clinical Dementia Rating scale plus NACC FTLD Module < 1) and 78 noncarriers enrolled through Advancing Research and Treatment in Frontotemporal Lobar Degeneration/Longitudinal Evaluation of Familial Frontotemporal Dementia Subjects studies completed the Executive Abilities: Measures and Instruments for Neurobehavioral Evaluation and Research (NIH-EXAMINER) and the UDS neuropsychological battery. Linear mixed-effects models were used to identify group differences in cognition at baseline and longitudinally. We examined associations between cognition, clinical functioning, and magnetic resonance imaging volumes.ResultsNIH-EXAMINER scores detected baseline and differences in slopes between carriers and noncarriers, even in carriers with a baseline Clinical Dementia Rating scale plus NACC FTLD Module = 0. NIH-EXAMINER declines were associated with worsening clinical symptoms and brain volume loss.DiscussionThe NIH-EXAMINER is sensitive to cognitive changes in presymptomatic familial FTLD and is a promising surrogate endpoint.

Published
2020

6. Utility of the global CDR® plus NACC FTLD rating and development of scoring rules: Data from the ARTFL/LEFFTDS Consortium

Author

Miyagawa, Toji, Brushaber, Danielle, Syrjanen, Jeremy, Kremers, Walter, Fields, Julie, Forsberg, Leah K, Heuer, Hilary W, Knopman, David, Kornak, John, Boxer, Adam, Rosen, Howard J, Boeve, Bradley F, Appleby, Brian, Bordelon, Yvette, Bove, Jessica, Brannelly, Patrick, Caso, Christina, Coppola, Giovanni, Dever, Reilly, Dheel, Christina, Dickerson, Bradford, Dickinson, Susan, Dominguez, Sophia, Domoto‐Reilly, Kimiko, Faber, Kelley, Ferrell, Jessica, Fishman, Ann, Fong, Jamie, Foroud, Tatiana, Gavrilova, Ralitza, Gearhart, Debra, Ghazanfari, Behnaz, Ghoshal, Nupur, Goldman, Jill S, Graff‐Radford, Jonathan, Graff‐Radford, Neill, Grant, Ian, Grossman, Murray, Haley, Dana, Hsiung, Robin, Huey, Edward, Irwin, David, Jones, David, Jones, Lynne, Kantarci, Kejal, Karydas, Anna, Kaufer, Daniel, Kerwin, Diana, Kraft, Ruth, Kramer, Joel, Kukull, Walter, Litvan, Irene, Lucente, Diane, Lungu, Codrin, Mackenzie, Ian, Maldonado, Miranda, Manoochehri, Masood, McGinnis, Scott, McKinley, Emily, Mendez, Mario F, Miller, Bruce, Multani, Namita, Onyike, Chiadi, Padmanabhan, Jaya, Pantelyat, Alexander, Pearlman, Rodney, Petrucelli, Leonard, Potter, Madeline, Rademakers, Rosa, Ramos, Eliana M, Rankin, Kate, Rascovsky, Katya, Roberson, Erik D, Rogalski, Emily, Sengdy, Pheth, Shaw, Leslie, Tartaglia, Maria C, Tatton, Nadine, Taylor, Joanne, Toga, Arthur, Trojanowski, John Q, Wang, Ping, Weintraub, Sandra, Wong, Bonnie, and Wszolek, Zbigniew

Subjects
Biological Psychology, Biomedical and Clinical Sciences, Psychology, Dementia, Frontotemporal Dementia (FTD), Neurosciences, Neurodegenerative, Acquired Cognitive Impairment, Clinical Trials and Supportive Activities, Clinical Research, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Aging, Brain Disorders, Aged, Aphasia, Primary Progressive, Cross-Sectional Studies, Female, Frontotemporal Lobar Degeneration, Humans, Male, Mental Status and Dementia Tests, Middle Aged, behavior, comportment, personality, CDR, CDR plus NACC FTLD, frontotemporal lobar degeneration, global rating, language, CDR®, behavior, comportment, and personality, Clinical Sciences, Geriatrics, Clinical sciences, Biological psychology
Abstract

IntroductionWe created global rating scoring rules for the CDR® plus NACC FTLD to detect and track early frontotemporal lobar degeneration (FTLD) and to conduct clinical trials in FTLD.MethodsThe CDR plus NACC FTLD rating was applied to 970 sporadic and familial participants from the baseline visit of Advancing Research and Treatment in Frontotemporal Lobar Degeneration (ARTFL)/Longitudinal Evaluation of Familial Frontotemporal Dementia Subjects (LEFFTDS). Each of the eight domains of the CDR plus NACC FTLD was equally weighed in determining the global score. An interrater reliability study was completed for 40 participants.ResultsThe CDR plus NACC FTLD showed very good interrater reliability. It was especially useful in detecting clinical features of mild non-fluent/agrammatic variant primary progressive aphasia participants.DiscussionThe global CDR plus NACC FTLD score could be an attractive outcome measure for clinical trials in symptomatic FTLD, and may be useful in natural history studies and clinical trials in FTLD spectrum disorders.

Published
2020

7. Tracking white matter degeneration in asymptomatic and symptomatic MAPT mutation carriers

Author

Chen, Qin, Boeve, Bradley F, Schwarz, Christopher G, Reid, Robert, Tosakulwong, Nirubol, Lesnick, Timothy G, Bove, Jessica, Brannelly, Patrick, Brushaber, Danielle, Coppola, Giovanni, Dheel, Christina, Dickerson, Bradford C, Dickinson, Susan, Faber, Kelley, Fields, Julie, Fong, Jamie, Foroud, Tatiana, Forsberg, Leah, Gavrilova, Ralitza H, Gearhart, Debra, Ghoshal, Nupur, Goldman, Jill, Graff-Radford, Jonathan, Graff-Radford, Neill R, Grossman, Murray, Haley, Dana, Heuer, Hilary W, Hsiung, Ging-Yuek R, Huey, Edward, Irwin, David J, Jack, Clifford R, Jones, David T, Jones, Lynne, Karydas, Anna M, Knopman, David S, Kornak, John, Kramer, Joel, Kremers, Walter, Kukull, Walter A, Lapid, Maria, Lucente, Diane, Lungu, Codrin, Mackenzie, Ian RA, Manoochehri, Masood, McGinnis, Scott, Miller, Bruce L, Pearlman, Rodney, Petrucelli, Leonard, Potter, Madeline, Rademakers, Rosa, Ramos, Eliana M, Rankin, Katherine P, Rascovsky, Katya, Sengdy, Pheth, Shaw, Leslie, Syrjanen, Jeremy, Tatton, Nadine, Taylor, Joanne, Toga, Arthur W, Trojanowski, John, Weintraub, Sandra, Wong, Bonnie, Boxer, Adam L, Rosen, Howie, Wszolek, Zbigniew, Kantarci, Kejal, and Consortium, LEFFTDS

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Dementia, Neurodegenerative, Aging, Acquired Cognitive Impairment, Biomedical Imaging, Neurosciences, Clinical Trials and Supportive Activities, Clinical Research, Brain Disorders, 2.1 Biological and endogenous factors, Adult, Aged, Diffusion Magnetic Resonance Imaging, Diffusion Tensor Imaging, Disease Progression, Female, Frontotemporal Dementia, Gray Matter, Heterozygote, Humans, Male, Middle Aged, Mutation, Neurodegenerative Diseases, Neuropsychological Tests, White Matter, tau Proteins, Diffusion tensor image, MAPT, Asymptomatic, Frontotemporal dementia, Longitudinal, LEFFTDS Consortium, Neurology & Neurosurgery, Biological psychology
Abstract

Our aim was to investigate the patterns and trajectories of white matter (WM) diffusion abnormalities in microtubule-associated protein tau (MAPT) mutations carriers. We studied 22 MAPT mutation carriers (12 asymptomatic, 10 symptomatic) and 20 noncarriers from 8 families, who underwent diffusion tensor imaging (DTI) and a subset (10 asymptomatic, 6 symptomatic MAPT mutation carriers, and 10 noncarriers) were followed annually (median = 4 years). Cross-sectional and longitudinal changes in mean diffusivity (MD) and fractional anisotropy were analyzed. Asymptomatic MAPT mutation carriers had higher MD in entorhinal WM, which propagated to the limbic tracts and frontotemporal projections in the symptomatic stage compared with noncarriers. Reduced fractional anisotropy and increased MD in the entorhinal WM were associated with the proximity to estimated and actual age of symptom onset. The annualized change of entorhinal MD on serial DTI was accelerated in MAPT mutation carriers compared with noncarriers. Entorhinal WM diffusion abnormalities precede the symptom onset and track with disease progression in MAPT mutation carriers. Our cross-sectional and longitudinal data showed a potential clinical utility for DTI to track neurodegenerative disease progression for MAPT mutation carriers in clinical trials.

Published
2019

8. Brain MR Spectroscopy Changes Precede Frontotemporal Lobar Degeneration Phenoconversion in Mapt Mutation Carriers

Author

Chen, Qin, Boeve, Bradley F, Tosakulwong, Nirubol, Lesnick, Timothy, Brushaber, Danielle, Dheel, Christina, Fields, Julie, Forsberg, Leah, Gavrilova, Ralitza, Gearhart, Debra, Haley, Dana, Gunter, Jeffrey L, Graff‐Radford, Jonathan, Jones, David, Knopman, David, Graff‐Radford, Neill, Kraft, Ruth, Lapid, Maria, Rademakers, Rosa, Wszolek, Zbigniew K, Rosen, Howie, Boxer, Adam L, and Kantarci, Kejal

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Biomedical Imaging, Aging, Neurodegenerative, Prevention, Clinical Research, Neurosciences, 2.1 Biological and endogenous factors, Aetiology, Good Health and Well Being, Adult, Biomarkers, Brain, Disease Progression, Female, Frontotemporal Lobar Degeneration, Heterozygote, Humans, Longitudinal Studies, Magnetic Resonance Spectroscopy, Male, Middle Aged, Mutation, tau Proteins, converter, frontotemporal lobar degeneration, longitudinal, MAPT, MRS, Neurology & Neurosurgery, Clinical sciences, Biological psychology
Abstract

Background and purposeThe objective of this study was to longitudinally investigate the trajectory of change in 1 H MRS measurements in asymptomatic MAPT mutation carriers who became symptomatic during follow-up, and to determine the time at which the neurochemical alterations accelerated during disease progression.MethodsWe identified eight MAPT mutations carriers who transitioned from asymptomatic to symptomatic disease during follow-up. All participants were longitudinally followed with an average of 7.75 years (range 4-11 years) and underwent two or more single voxel 1 H MRS examinations from the posterior cingulate voxel, with a total of 60 examinations. The rate of longitudinal change for each metabolite was estimated using linear mixed models. A flex point model was used to estimate the flex time point of the change in slope.ResultsThe decrease in the NAA/mI ratio accelerated 2.09 years prior to symptom onset, and continued to decline. A similar trajectory was observed in the presumed glial marker mI/Cr ratio accelerating 1.86 years prior to symptom onset.ConclusionsOur findings support the potential use of longitudinal 1 H MRS for monitoring the neurodegenerative progression in MAPT mutation carriers starting from the asymptomatic stage.

Published
2019

9. Frontal lobe 1H MR spectroscopy in asymptomatic and symptomatic MAPT mutation carriers.

Author

Chen, Qin, Boeve, Bradley F, Tosakulwong, Nirubol, Lesnick, Timothy, Brushaber, Danielle, Dheel, Christina, Fields, Julie, Forsberg, Leah, Gavrilova, Ralitza, Gearhart, Debra, Haley, Dana, Gunter, Jeffrey L, Graff-Radford, Jonathan, Jones, David, Knopman, David, Graff-Radford, Neill, Kraft, Ruth, Lapid, Maria, Rademakers, Rosa, Syrjanen, Jeremy, Wszolek, Zbigniew K, Rosen, Howie, Boxer, Adam L, and Kantarci, Kejal

Subjects
Neurodegenerative, Prevention, Neurosciences, Dementia, Brain Disorders, Clinical Research, Acquired Cognitive Impairment, Biomedical Imaging, Frontotemporal Dementia (FTD), Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Aetiology, 2.1 Biological and endogenous factors, Neurological, Adult, Aspartic Acid, Asymptomatic Diseases, Biomarkers, Case-Control Studies, Creatine, Female, Frontal Lobe, Frontotemporal Lobar Degeneration, Heterozygote, Humans, Inositol, Male, Middle Aged, Mutation, Proton Magnetic Resonance Spectroscopy, Young Adult, tau Proteins, Clinical Sciences, Cognitive Sciences, Neurology & Neurosurgery
Abstract

ObjectiveTo determine the frontal lobe proton magnetic resonance spectroscopy (1H MRS) abnormalities in asymptomatic and symptomatic carriers of microtubule-associated protein tau (MAPT) mutations.MethodsWe recruited patients with MAPT mutations from 5 individual families, who underwent single voxel 1H MRS from the medial frontal lobe at 3T (n = 19) from the Longitudinal Evaluation of Familial Frontotemporal Dementia Subjects (LEFFTDS) Study at the Mayo Clinic site. Asymptomatic MAPT mutation carriers (n = 9) had Frontotemporal Lobar Degeneration Clinical Dementia Rating Sum of Boxes (FTLD-CDR SOB) score of zero, and symptomatic MAPT mutation carriers (n = 10) had a median FTLD-CDR SOB score of 5. Noncarriers from healthy first-degree relatives of the patients were recruited as controls (n = 25). The demographic aspects and 1H MRS metabolite ratios were compared by use of the Fisher exact test for sex and linear mixed models to account for within-family correlations. We used Tukey contrasts for pair-wise comparisons.ResultsAsymptomatic MAPT mutation carriers had lower neuronal marker N-acetylaspartate (NAA)/creatine (Cr) (p = 0.001) and lower NAA/myo-inositol (mI) (p = 0.026) than noncarriers after adjustment for age. Symptomatic MAPT mutation carriers had lower NAA/Cr (p = 0.01) and NAA/mI (p = 0.01) and higher mI/Cr (p = 0.02) compared to noncarriers after adjustment for age. Furthermore, NAA/Cr (p = 0.006) and NAA/mI (p < 0.001) ratios decreased, accompanied by an increase in mI/Cr ratio (p = 0.001), as the ages of carriers approached and passed the age at symptom onset.ConclusionFrontal lobe neurochemical alterations measured with 1H MRS precede the symptom onset in MAPT mutation carriers. Frontal lobe 1H MRS is a potential biomarker for early neurodegenerative processes in MAPT mutation carriers.

Published
2019

10. P2‐314: THE MULTIDOMAIN IMPAIRMENT RATING (MIR) SCALE: INITIAL RELIABILITY DATA ON A MULTIDIMENSIONAL SCALE DESIGNED FOR FTLD SPECTRUM DISORDERS

Author

Forsberg, Leah K, Boeve, Bradley F, Boxer, Adam L, Rosen, Howard J, Kornak, John, Heuer, Hilary W, Fields, Julie A, Brushaber, Danielle, Machulda, Mary M, Sturm, Virginia, Staffaroni, Adam M, Ljubenkov, Peter A, Denver, Reilly, Ong, Elise, Appleby, Brian, Bordelon, Yvette M, Brannelly, Patrick, Coppola, Giovanni, Dickerson, Brad C, Dickinson, Susan, Kimiko, Domoto-Reilly, Faber, Kelley, Fong, Jamie, Foroud, Tatiana M, Gavrilova, Ralitza H, Gearhart, Debra, Ghoshal, Nupur, Goldman, Jill, Graff-Radford, Jonathan, Graff-Radford, Neil R, Grossman, Murray, Hsiung, Ging-Yuek Robin, Huey, Edward D, Irwin, David, Jones, David T, Kantarci, Kejal, Karydas, Anna M, Kaufer, Daniel, Kerwin, Diana R, Knopman, David S, Kraft, Ruth A, Kramer, Joel H, Kremers, Walter K, Kukull, Walter A, Litvan, Irene, Lucente, Diane E, Lungu, Codrin, Mackenzie, Ian R, McGinnis, Scott M, Mendez, Mario F, Miller, Bruce L, Onyike, Chiadi U, Pantelyat, Alex, Pearlman, Rodney, Petrucelli, Leonard, Potter, Madeline, Rademakers, Rosa, Ramos, Eliana Marisa, Rankin, Katherine, Rascovsky, Katya, Roberson, Erik D, Rogalski, Emily J, Shaw, Leslie M, Sutherland, Marg, Syrjanen, Jeremy, Tartaglia, Carmela, Tatton, Nadine, Taylor, Joanne, Toga, Arthur W, Trojanowski, John Q, Weintraub, Sandra, Wong, Bonnie, and Wszolek, Zbigniew

Subjects
Clinical Sciences, Neurosciences, Geriatrics
Published
2019

11. Rates of lobar atrophy in asymptomatic MAPT mutation carriers.

Author

Chen, Qin, Boeve, Bradley F, Senjem, Matthew, Tosakulwong, Nirubol, Lesnick, Timothy G, Brushaber, Danielle, Dheel, Christina, Fields, Julie, Forsberg, Leah, Gavrilova, Ralitza, Gearhart, Debra, Graff-Radford, Jonathan, Graff-Radford, Neill R, Jack, Clifford R, Jones, David T, Knopman, David S, Kremers, Walter K, Lapid, Maria, Rademakers, Rosa, Syrjanen, Jeremy, Boxer, Adam L, Rosen, Howie, Wszolek, Zbigniew K, Kantarci, Kejal, and LEFFTDS Consortium

Subjects
LEFFTDS Consortium, Asymptomatic, Frontotemporal dementia, Longitudinal, MAPT, Magnetic resonance image, Prevention, Brain Disorders, Acquired Cognitive Impairment, Dementia, Neurodegenerative, Neurosciences, Rare Diseases
Abstract

IntroductionThe aim of this study was to investigate the rates of lobar atrophy in the asymptomatic microtubule-associated protein tau (MAPT) mutation carriers.MethodsMAPT mutation carriers (n = 14; 10 asymptomatic, 4 converters from asymptomatic to symptomatic) and noncarriers (n = 13) underwent structural magnetic resonance imaging and were followed annually with a median of 9.2 years. Longitudinal changes in lobar atrophy were analyzed using the tensor-based morphometry with symmetric normalization algorithm.ResultsThe rate of temporal lobe atrophy in asymptomatic MAPT mutation carriers was faster than that in noncarriers. Although the greatest rate of atrophy was observed in the temporal lobe in converters, they also had increased atrophy rates in the frontal and parietal lobes compared to noncarriers.DiscussionAccelerated decline in temporal lobe volume occurs in asymptomatic MAPT mutation carriers followed by the frontal and parietal lobe in those who have become symptomatic. The findings have implications for monitoring the progression of neurodegeneration during clinical trials in asymptomatic MAPT mutation carriers.

Published
2019

12. Rates of lobar atrophy in asymptomatic MAPT mutation carriers

Author

Coppola, Giovanni, Dickerson, Bradford C., Dickinson, Susan, Faber, Kelly, Fong, Jamie, Foroud, Tatiana, Ghoshal, Nupur, MurrayGrossman, Jill Goldman, Heuer, HilaryW., Hsiao, John, Hsiung, Ging-Yuek R., Huey, Edward, Irwin, David J., Karydas, Anna M., Kornak, John, Kramer, Joel, Kukull, Walter A., Lucente, Diane, Lungu, Codrin, Mackenzie, Ian R.A., McGinnis, Scott, Miller, Bruce L., Petrucelli, Leonard, Potter, Madeline, Ramos, Eliana M., Rankin, Katherine P., Rascovsky, Katya, Shaw, Leslie, Sutherland, Marg, Tatton, Nadine, Taylor, Joanne, Toga, Arthur W., Trojanowski, John, Weintraub, Sandra, Wong, Bonnie, Chen, Qin, Boeve, Bradley F., Senjem, Matthew, Tosakulwong, Nirubol, Lesnick, Timothy G., Brushaber, Danielle, Dheel, Christina, Fields, Julie, Forsberg, Leah, Gavrilova, Ralitza, Gearhart, Debra, Graff-Radford, Jonathan, Graff-Radford, Neill R., Jack, Clifford R., Jr., Jones, David T., Knopman, David S., Kremers, Walter K., Lapid, Maria, Rademakers, Rosa, Syrjanen, Jeremy, Boxer, Adam L., Rosen, Howie, Wszolek, Zbigniew K., and Kantarci, Kejal

Published
2019
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13. The longitudinal evaluation of familial frontotemporal dementia subjects protocol: Framework and methodology

Author

Boeve, Bradley, Bove, Jessica, Brannelly, Patrick, Brushaber, Danielle, Coppola, Giovanni, Dever, Rielly, Dheel, Christina, Dickerson, Bradford, Dickinson, Susan, Faber, Kelley, Fields, Julie, Fong, Jamie, Foroud, Tatiana, Forsberg, Leah, Gavrilova, Ralitza, Gearhart, Debra, Ghoshal, Nupur, Goldman, Jennifer, Graff-Radford, Jonathan, Graff-Radford, Neill, Grossman, Murray, Haley, Dana, Heuer, Hilary, Hsiung, Ging-Yuek Robin, Huey, Edward, Irwin, David, Jones, David, Jones, Lynne, Kantarci, Kejal, Karydas, Anna, Knopman, David, Kornak, John, Kraft, Ruth, Kramer, Joel, Kremers, Walter, Kukull, Walter, Lapid, Maria, Lucente, Diane, Mackenzie, Ian, Manoochehri, Masood, McGinnis, Scott, Miller, Bruce, Pearlman, Rodney, Petrucelli, Len, Potter, Madeline, Rademakers, Rosa, Ramos, Elena, Rankin, Kate, Rascovsky, Katya, Sengdy, Pheth, Shaw, Les, Syrjanen, Jeremy, Tatton, Nadine, Taylor, Joanne, Toga, Arthur, Trojanowski, John, Weintraub, Sandra, Wong, Bonnie, Wszolek, Zbigniew, Boxer, Adam, and Rosen, Howard

Published
2019
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14. Individualized atrophy scores predict dementia onset in familial frontotemporal lobar degeneration

Author

Staffaroni, Adam M., Cobigo, Yann, Goh, Sheng-Yang M., Kornak, John, Bajorek, Lynn, Chiang, Kevin, Appleby, Brian, Bove, Jessica, Bordelon, Yvette, Brannelly, Patrick, Brushaber, Danielle, Caso, Christina, Coppola, Giovanni, Dever, Reilly, Dheel, Christina, Dickerson, Bradford C., Dickinson, Susan, Dominguez, Sophia, Domoto-Reilly, Kimiko, Faber, Kelly, Ferrall, Jessica, Fields, Julie A., Fishman, Ann, Fong, Jamie, Foroud, Tatiana, Forsberg, Leah K., Gavrilova, Ralitza, Gearhart, Debra, Ghazanfari, Behnaz, Ghoshal, Nupur, Goldman, Jill, Graff-Radford, Jonathan, Graff-Radford, Neill, Grant, Ian, Grossman, Murray, Haley, Dana, Heuer, Hilary W., Hsiung, Ging-Yuek, Huey, Edward D., Irwin, David J., Jones, David T., Jones, Lynne, Kantarci, Kejal, Karydas, Anna, Kaufer, Daniel I., Kerwin, Diana R., Knopman, David S., Kraft, Ruth, Kramer, Joel H., Kremers, Walter K., Kukull, Walter A., Litvan, Irene, Ljubenkov, Peter A., Lucente, Diane, Lungu, Codrin, Mackenzie, Ian R., Maldonado, Miranda, Manoochehri, Masood, McGinnis, Scott M., McKinley, Emily, Mendez, Mario F., Miller, Bruce L., Multani, Namita, Onyike, Chiadi, Padmanabhan, Jaya, Pantelyat, Alex, Pearlman, Rodney, Petrucelli, Len, Potter, Madeline, Rademakers, Rosa, Ramos, Eliana Marisa, Rankin, Katherine P., Rascovsky, Katya, Roberson, Erik D., Rogalski, Emily, Sengdy, Pheth, Shaw, Leslie M., Syrjanen, Jeremy, Tartaglia, M. Carmela, Tatton, Nadine, Taylor, Joanne, Toga, Arthur, Trojanowski, John Q., Weintraub, Sandra, Wang, Ping, Wong, Bonnie, Wszolek, Zbigniew, Boxer, Adam L., Boeve, Brad F., and Rosen, Howard J.

Published
2019
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15. Use of the CDR® plus NACC FTLD in mild FTLD: Data from the ARTFL/LEFFTDS consortium

Author

Appleby, Brian, Bordelon, Yvette, Bove, Jessica, Brannelly, Patrick, Caso, Christina, Coppola, Giovanni, Dever, Reilly, Dheel, Christina, Dickerson, Bradford, Dickinson, Susan, Dominguez, Sophia, Domoto-Reilly, Kimiko, Faber, Kelley, Ferrell, Jessica, Fishman, Ann, Fong, Jamie, Foroud, Tatiana, Gavrilova, Ralitza, Gearhart, Debra, Ghazanfari, Behnaz, Ghoshal, Nupur, Goldman, Jill S., Graff-Radford, Jonathan, Graff-Radford, Neill, Grant, Ian, Grossman, Murray, Haley, Dana, Hsiung, Robin, Huey, Edward, Irwin, David, Jones, David, Jones, Lynne, Kantarci, Kejal, Karydas, Anna, Kaufer, Daniel, Kerwin, Diana, Kraft, Ruth, Kramer, Joel, Kukull, Walter, Litvan, Irene, Lucente, Diane, Lungu, Codrin, Mackenzie, Ian, Maldonado, Miranda, Manoochehri, Masood, McGinnis, Scott, McKinley, Emily, Mendez, Mario F., Miller, Bruce, Multani, Namita, Onyike, Chiadi, Padmanabhan, Jaya, Pantelyat, Alexander, Pearlman, Rodney, Petrucelli, Leonard, Potter, Madeline, Rademakers, Rosa, Ramos, Eliana M., Rankin, Kate, Rascovsky, Katya, Roberson, Erik D., Rogalski, Emily, Sengdy, Pheth, Shaw, Leslie, Tartaglia, Maria C., Tatton, Nadine, Taylor, Joanne, Toga, Arthur, Trojanowski, John Q., Wang, Ping, Weintraub, Sandra, Wong, Bonnie, Wszolek, Zbigniew, Miyagawa, Toji, Brushaber, Danielle, Syrjanen, Jeremy, Kremers, Walter, Fields, Julie, Forsberg, Leah K., Heuer, Hilary W., Knopman, David, Kornak, John, Boxer, Adam, Rosen, Howie, and Boeve, Bradley

Published
2019
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16. Assessment of executive function declines in presymptomatic and mildly symptomatic familial frontotemporal dementia: NIH-EXAMINER as a potential clinical trial endpoint

Author

Staffaroni, Adam M., Bajorek, Lynn, Casaletto, Kaitlin B., Cobigo, Yann, Goh, Sheng-Yang M., Wolf, Amy, Heuer, Hilary W., Elahi, Fanny M., Ljubenkov, Peter A., Dever, Reilly, Kornak, John, Appleby, Brian, Bove, Jessica, Bordelon, Yvette, Brannelly, Patrick, Brushaber, Danielle, Caso, Christina, Coppola, Giovanni, Dheel, Christina, Dickerson, Bradford C., Dickinson, Susan, Dominguez, Sophia, Domoto-Reilly, Kimiko, Faber, Kelly, Ferrall, Jessica, Fields, Julie A., Fishman, Ann, Fong, Jamie, Foroud, Tatiana, Forsberg, Leah K., Gavrilova, Ralitza, Gearhart, Debra, Ghazanfari, Behnaz, Ghoshal, Nupur, Goldman, Jill, Graff-Radford, Jonathan, Graff-Radford, Neill, Grant, Ian, Grossman, Murray, Haley, Dana, Hsiung, Ging-Yuek, Huey, Edward D., Irwin, David J., Jones, David T., Jones, Lynne, Kantarci, Kejal, Karydas, Anna, Kaufer, Daniel I., Kerwin, Diana R., Knopman, David S., Kraft, Ruth, Kremers, Walter K., Kukull, Walter A., Litvan, Irene, Lucente, Diane, Lungu, Codrin, Mackenzie, Ian R., Maldonado, Miranda, Manoochehri, Masood, McGinnis, Scott M., McKinley, Emily, Mendez, Mario F., Miller, Bruce L., Multani, Namita, Onyike, Chiadi, Padmanabhan, Jaya, Pantelyat, Alex, Pearlman, Rodney, Petrucelli, Len, Potter, Madeline, Rademakers, Rosa, Ramos, Eliana Marisa, Rankin, Katherine P., Rascovsky, Katya, Roberson, Erik D., Rogalski, Emily, Sengdy, Pheth, Shaw, Leslie M., Syrjanen, Jeremy, Tartaglia, M. Carmela, Tatton, Nadine, Taylor, Joanne, Toga, Arthur, Trojanowski, John Q., Weintraub, Sandra, Wang, Ping, Wong, Bonnie, Wszolek, Zbigniew, Boxer, Adam L., Boeve, Brad F., Kramer, Joel H., and Rosen, Howard J.

Published
2019
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18. WITHDRAWN: Clinical and volumetric changes with increasing functional impairment in familial frontotemporal lobar degeneration

Author

Olney, Nicholas T., Ong, Elise, Goh, Sheng-Yang M., Bajorek, Lynn, Dever, Reilly, Staffaroni, Adam M., Cobigo, Yann, Bock, Meredith, Chiang, Kevin, Ljubenkov, Peter, Kornak, John, Heuer, Hilary W., Wang, Ping, Rascovsky, Katya, Wolf, Amelia, Appleby, Brian, Bove, Jessica, Bordelon, Yvette, Brannelly, Patrick, Brushaber, Danielle, Caso, Christine, Coppola, Giovanni, Dickerson, Bradford C., Dickinson, Susan, Domoto-Reilly, Kimiko, Faber, Kelly, Ferrall, Jessica, Fields, Julie, Fishman, Ann, Fong, Jamie, Foroud, Tatiana, Forsberg, Leah K., Gearhart, Debra J., Ghazanfari, Behnaz, Ghoshal, Nupur, Goldman, Jill, Graff-Radford, Jonathan, Graff-Radford, Neill R., Grant, Ian, Grossman, Murray, Haley, Dana, Hsiung, Gingyuek, Huey, Edward D., Irwin, David J., Jones, David T., Kantarci, Kejal, Karydas, Anna M., Kaufer, Daniel, Kerwin, Diana, Knopman, David S., Kramer, Joel H., Kraft, Ruth, Kremers, Walter, Kukull, Walter, Lapid, Maria I., Litvan, Irene, Mackenzie, Ian R., Maldonado, Miranda, Manoochehri, Masood, McGinnis, Scott M., McKinley, Emily C., Mendez, Mario F., Miller, Bruce L., Onyike, Chiadi, Pantelyat, Alex, Pearlman, Rodney, Petrucelli, Len, Potter, Madeleine, Rademakers, Rosa, Ramos, Eliana M., Rankin, Katherine P., Roberson, Erik D., Rogalski, Emily, Sengdy, Pheth, Shaw, Leslie M., Syrjanen, Jeremy, Tartaglia, M. Carmela, Tatton, Nadine, Taylor, Joanne, Toga, Arthur, Trojanowski, John Q., Weintraub, Sandra, Wong, Bonnie, Wszolek, Zbigniew, Boxer, Adam L., Boeve, Brad F., and Rosen, Howard J.

Published
2023
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21. Trajectory of lobar atrophy in asymptomatic and symptomatic GRN mutation carriers: a longitudinal MRI study

Author

Chen, Qin, primary, Boeve, Bradley F., additional, Senjem, Matthew, additional, Tosakulwong, Nirubol, additional, Lesnick, Timothy, additional, Brushaber, Danielle, additional, Dheel, Christina, additional, Fields, Julie, additional, Forsberg, Leah, additional, Gavrilova, Ralitza, additional, Gearhart, Debra, additional, Graff-Radford, Jonathan, additional, Graff-Radford, Neill, additional, Jack, Clifford R., additional, Jones, David, additional, Knopman, David, additional, Kremers, Walter K., additional, Lapid, Maria, additional, Rademakers, Rosa, additional, Ramos, Eliana Marisa, additional, Syrjanen, Jeremy, additional, Boxer, Adam L., additional, Rosen, Howie, additional, Wszolek, Zbigniew K., additional, and Kantarci, Kejal, additional

Published
2020
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22. Tracking white matter degeneration in asymptomatic and symptomatic MAPT mutation carriers

Author

Chen, Qin, primary, Boeve, Bradley F., additional, Schwarz, Christopher G., additional, Reid, Robert, additional, Tosakulwong, Nirubol, additional, Lesnick, Timothy G., additional, Bove, Jessica, additional, Brannelly, Patrick, additional, Brushaber, Danielle, additional, Coppola, Giovanni, additional, Dheel, Christina, additional, Dickerson, Bradford C., additional, Dickinson, Susan, additional, Faber, Kelley, additional, Fields, Julie, additional, Fong, Jamie, additional, Foroud, Tatiana, additional, Forsberg, Leah, additional, Gavrilova, Ralitza H., additional, Gearhart, Debra, additional, Ghoshal, Nupur, additional, Goldman, Jill, additional, Graff-Radford, Jonathan, additional, Graff-Radford, Neill R., additional, Grossman, Murray, additional, Haley, Dana, additional, Heuer, Hilary W., additional, Hsiung, Ging-Yuek R., additional, Huey, Edward, additional, Irwin, David J., additional, Jack, Clifford R., additional, Jones, David T., additional, Jones, Lynne, additional, Karydas, Anna M., additional, Knopman, David S., additional, Kornak, John, additional, Kramer, Joel, additional, Kremers, Walter, additional, Kukull, Walter A., additional, Lapid, Maria, additional, Lucente, Diane, additional, Lungu, Codrin, additional, Mackenzie, Ian R.A., additional, Manoochehri, Masood, additional, McGinnis, Scott, additional, Miller, Bruce L., additional, Pearlman, Rodney, additional, Petrucelli, Leonard, additional, Potter, Madeline, additional, Rademakers, Rosa, additional, Ramos, Eliana M., additional, Rankin, Katherine P., additional, Rascovsky, Katya, additional, Sengdy, Pheth, additional, Shaw, Leslie, additional, Syrjanen, Jeremy, additional, Tatton, Nadine, additional, Taylor, Joanne, additional, Toga, Arthur W., additional, Trojanowski, John, additional, Weintraub, Sandra, additional, Wong, Bonnie, additional, Boxer, Adam L., additional, Rosen, Howie, additional, Wszolek, Zbigniew, additional, and Kantarci, Kejal, additional

Published
2019
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27. P2-329: TRACKING WHITE MATTER DEGENERATION IN ASYMPTOMATIC AND SYMPTOMATIC MAPT MUTATION CARRIERS WITH DTI

Author

Chen, Qin, primary, Boeve, Bradley F., additional, Schwarz, Christopher G., additional, Reid, Robert I., additional, Tosakulwong, Nirubol, additional, Lesnick, Timothy G., additional, Bove, Jessica, additional, Brannelly, Patrick, additional, Brushaber, Danielle, additional, Coppola, Giovanni, additional, Dheel, Christina, additional, Dickerson, Brad C., additional, Dickinson, Susan, additional, Faber, Kelley, additional, Fields, Julie A., additional, Fong, Jamie, additional, Foroud, Tatiana M., additional, Forsberg, Leah K., additional, Gavrilova, Ralitza H., additional, Gearhart, Debra, additional, Ghoshal, Nupur, additional, Goldman, Jill, additional, Graff-Radford, Jonathan, additional, Graff-Radford, Neill R., additional, Grossman, Murray, additional, Haley, Dana, additional, Heuer, Hilary W., additional, Robin Hsiung, Ging-Yuek, additional, Huey, Edward D., additional, Irwin, David, additional, Jack, Clifford R., additional, Jones, David T., additional, Jones, Lynne, additional, Karydas, Anna M., additional, Knopman, David S., additional, Kornak, John, additional, Kramer, Joel H., additional, Kremers, Walter K., additional, Kukull, Walter A., additional, Lapid, Maria I., additional, Lucente, Diane E., additional, Lungu, Codrin, additional, Mackenzie, Ian R., additional, Manoochehri, Masood, additional, McGinnis, Scott, additional, Miller, Bruce L., additional, Pearlman, Rodney, additional, Petrucelli, Leonard, additional, Potter, Madeline, additional, Rademakers, Rosa, additional, Ramos, Eliana Marisa, additional, Rankin, Katherine, additional, Rascovsky, Katya, additional, Sengdy, Pheth, additional, Shaw, Leslie M., additional, Syrjanen, Jeremy, additional, Tatton, Nadine, additional, Taylor, Joanne, additional, Toga, Arthur W., additional, Trojanowski, John Q., additional, Weintraub, Sandra, additional, Wong, Bonnie, additional, Boxer, Adam L., additional, Rosen, Howard J., additional, Wszolek, Zbigniew, additional, and Kantarci, Kejal, additional

Published
2019
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28. O2-09-06: TRAJECTORY OF LOBAR ATROPHY IN ASYMPTOMATIC AND SYMPTOMATIC GRN MUTATION CARRIERS: A LONGITUDINAL TBM-SYN STUDY

Author

Chen, Qin, primary, Boeve, Bradley F., additional, Senjem, Matthew L., additional, Tosakulwong, Nirubol, additional, Lesnick, Timothy G., additional, Brushaber, Danielle, additional, Dheel, Christina, additional, Fields, Julie A., additional, Forsberg, Leah K., additional, Gavrilova, Ralitza H., additional, Gearhart, Debra, additional, Graff-Radford, Jonathan, additional, Graff-Radford, Neill R., additional, Jack, Clifford R., additional, Jones, David T., additional, Knopman, David S., additional, Kremers, Walter K., additional, Lapid, Maria I., additional, Rademakers, Rosa, additional, Syrjanen, Jeremy, additional, Boxer, Adam L., additional, Rosen, Howard J., additional, Wszolek, Zbigniew, additional, and Kantarci, Kejal, additional

Published
2019
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29. P2-314: THE MULTIDOMAIN IMPAIRMENT RATING (MIR) SCALE: INITIAL RELIABILITY DATA ON A MULTIDIMENSIONAL SCALE DESIGNED FOR FTLD SPECTRUM DISORDERS

Author

Forsberg, Leah K., primary, Boeve, Bradley F., additional, Boxer, Adam L., additional, Rosen, Howard J., additional, Kornak, John, additional, Heuer, Hilary W., additional, Fields, Julie A., additional, Brushaber, Danielle, additional, Machulda, Mary M., additional, Sturm, Virginia, additional, Staffaroni, Adam M., additional, Ljubenkov, Peter A., additional, Denver, Reilly, additional, Ong, Elise, additional, Appleby, Brian, additional, Bordelon, Yvette M., additional, Brannelly, Patrick, additional, Coppola, Giovanni, additional, Dickerson, Brad C., additional, Dickinson, Susan, additional, Kimiko, Domoto-Reilly, additional, Faber, Kelley, additional, Fong, Jamie, additional, Foroud, Tatiana M., additional, Gavrilova, Ralitza H., additional, Gearhart, Debra, additional, Ghoshal, Nupur, additional, Goldman, Jill, additional, Graff-Radford, Jonathan, additional, Graff-Radford, Neil R., additional, Grossman, Murray, additional, Robin Hsiung, Ging-Yuek, additional, Huey, Edward D., additional, Irwin, David, additional, Jones, David T., additional, Kantarci, Kejal, additional, Karydas, Anna M., additional, Kaufer, Daniel, additional, Kerwin, Diana R., additional, Knopman, David S., additional, Kraft, Ruth A., additional, Kramer, Joel H., additional, Kremers, Walter K., additional, Kukull, Walter A., additional, Litvan, Irene, additional, Lucente, Diane E., additional, Lungu, Codrin, additional, Mackenzie, Ian R., additional, McGinnis, Scott M., additional, Mendez, Mario F., additional, Miller, Bruce L., additional, Onyike, Chiadi U., additional, Pantelyat, Alex, additional, Pearlman, Rodney, additional, Petrucelli, Leonard, additional, Potter, Madeline, additional, Rademakers, Rosa, additional, Ramos, Eliana Marisa, additional, Rankin, Katherine, additional, Rascovsky, Katya, additional, Roberson, Erik D., additional, Rogalski, Emily J., additional, Shaw, Leslie M., additional, Sutherland, Marg, additional, Syrjanen, Jeremy, additional, Tartaglia, Carmela, additional, Tatton, Nadine, additional, Taylor, Joanne, additional, Toga, Arthur W., additional, Trojanowski, John Q., additional, Weintraub, Sandra, additional, Wong, Bonnie, additional, and Wszolek, Zbigniew, additional

Published
2019
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30. P3‐364: RATES OF LOBAR ATROPHY IN ASYMPTOMATIC MAPT MUTATION CARRIERS

Author

Chen, Qin, primary, Boeve, Bradley F., additional, Senjem, Matthew L., additional, Tosakulwong, Nirubol, additional, Lesnick, Timothy G., additional, Brushaber, Danielle, additional, Dheel, Christina, additional, Fields, Julie A., additional, Forsberg, Leah K., additional, Gavrilova, Ralitza H., additional, Gearhart, Debra, additional, Graff-Radford, Jonathan, additional, Graff-Radford, Neill R., additional, Jack, Clifford R., additional, Jones, David T., additional, Knopman, David S., additional, Kremers, Walter K., additional, Lapid, Maria I., additional, Rademakers, Rosa, additional, Syrjanen, Jeremy, additional, Boxer, Adam L., additional, Rosen, Howard J., additional, Wszolek, Zbigniew, additional, and Kantarci, Kejal, additional

Published
2019
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33. P2‐430: MR SPECTROSCOPY FROM FRONTAL LOBE AND POSTERIOR CINGULATE GYRUS IN ASYMPTOMATIC AND SYMPTOMATIC MICROTUBULE‐ASSOCIATED PROTEIN TAU (MAPT) MUTATION CARRIERS

Author

Chen, Qin, primary, Boeve, Bradley F., additional, Brushaber, Danielle, additional, Dheel, Christina, additional, Fields, Julie A., additional, Forsberg, Leah K., additional, Gavrilova, Ralitza H., additional, Gearhart, Debra, additional, Haley, Dana, additional, Graff-Radford, Jonathan, additional, Jones, David T., additional, Knopman, David S., additional, Graff-Radford, Neill R., additional, Kraft, Ruth A., additional, Lapid, Maria I., additional, Rademakers, Rosa, additional, Syrjanen, Jeremy, additional, Wszolek, Zbigniew, additional, Rosen, Howard J., additional, Boxer, Adam L., additional, and Kantarci, Kejal, additional

Published
2018
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34. P1‐420: ACCELERATED NEUROCHEMICAL CHANGES PRIOR TO PHENOCONVERSION TO FRONTOTEMPORAL LOBAR DEGENERATION IN PRESYMPTOMATIC MICROTUBULE‐ASSOCIATED PROTEIN TAU (MAPT) MUTATION CARRIERS: A LONGITUDINAL MRS STUDY

Author

Chen, Qin, primary, Boeve, Bradley F., additional, Tosakulwong, Nirubol, additional, Lesnick, Timothy G., additional, Brushaber, Danielle, additional, Dheel, Christina, additional, Fields, Julie A., additional, Forsberg, Leah K., additional, Gavrilova, Ralitza H., additional, Gearhart, Debra, additional, Haley, Dana, additional, Gunter, Jeffrey L., additional, Graff-Radford, Jonathan, additional, Jones, David T., additional, Knopman, David S., additional, Graff-Radford, Neill R., additional, Kraft, Ruth A., additional, Lapid, Maria I., additional, Rademakers, Rosa, additional, Syrjanen, Jeremy, additional, Wszolek, Zbigniew, additional, Rosen, Howard J., additional, Boxer, Adam L., additional, and Kantarci, Kejal, additional

Published
2018
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35. O2‐14‐01: CHARACTERISTICS AND PROGRESS OF 320 SUBJECTS IN THE LONGITUDINAL EVALUATION OF FAMILIAL FRONTOTEMPORAL DEMENTIA SUBJECTS (LEFFTDS) PROTOCOL

Author

Forsberg, Leah K., primary, Boeve, Bradley F., additional, Rosen, Howard J., additional, Boxer, Adam L., additional, Bove, Jessica, additional, Brushaber, Danielle, additional, Coppola, Giovanni, additional, Dheel, Christina, additional, Dickerson, Brad C., additional, Dickinson, Susan, additional, Faber, Kelley, additional, Fields, Julie A., additional, Fong, Jamie, additional, Foroud, Tatiana M., additional, Gavrilova, Ralitza H., additional, Gearhart, Debra, additional, Ghoshal, Nupur, additional, Goldman, Jill, additional, Graff-Radford, Jonathan, additional, Graff-Radford, Neill R., additional, Grossman, Murray, additional, Haley, Dana, additional, Heuer, Hilary W., additional, Hsiao, John, additional, Robin Hsiung, Ging-Yuek, additional, Huey, Edward D., additional, Irwin, David J., additional, Jones, David T., additional, Jones, Lynne, additional, Kantarci, Kejal, additional, Karydas, Anna M., additional, Knopman, David S., additional, Kornak, John, additional, Kramer, Joel H., additional, Kremers, Walter K., additional, Kukull, Walter A., additional, Lapid, Maria I., additional, Lucente, Diane, additional, Mackenzie, Ian R., additional, Manoochehri, Masood, additional, McGinnis, Scott M., additional, Miller, Bruce L., additional, Pearlman, Rodney, additional, Petrucelli, Leonard, additional, Potter, Madeline, additional, Rademakers, Rosa, additional, Rankin, Katherine, additional, Rascovsky, Katya, additional, Sengdy, Pheth, additional, Shaw, Leslie M., additional, Sutherland, Marg, additional, Syrjanen, Jeremy, additional, Tatton, Nadine, additional, Taylor, Joanne, additional, Toga, Arthur W., additional, Trojanowski, John Q., additional, Weintraub, Sandra, additional, Wong, Bonnie, additional, and Wszolek, Zbigniew, additional

Published
2018
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37. TRAJECTORY OF LOBAR ATROPHY IN ASYMPTOMATIC AND SYMPTOMATIC GRN MUTATION CARRIERS: A LONGITUDINAL TBM-SYN STUDY

Author

Chen, Qin, Boeve, Bradley F., Senjem, Matthew L., Tosakulwong, Nirubol, Lesnick, Timothy G., Brushaber, Danielle, Dheel, Christina, Fields, Julie A., Forsberg, Leah K., Gavrilova, Ralitza H., Gearhart, Debra, Graff-Radford, Jonathan, Graff-Radford, Neill R., Jack, Clifford R., Jr., Jones, David T., Knopman, David S., Kremers, Walter K., Lapid, Maria I., Rademakers, Rosa, Syrjanen, Jeremy, Boxer, Adam L., Rosen, Howard J., Wszolek, Zbigniew, and Kantarci, Kejal

Published
2019
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38. CHARACTERISTICS AND PROGRESS OF 320 SUBJECTS IN THE LONGITUDINAL EVALUATION OF FAMILIAL FRONTOTEMPORAL DEMENTIA SUBJECTS (LEFFTDS) PROTOCOL

Author

Forsberg, Leah K., Boeve, Bradley F., Rosen, Howard J., Boxer, Adam L., Bove, Jessica, Brushaber, Danielle, Coppola, Giovanni, Dheel, Christina, Dickerson, Brad C., Dickinson, Susan, Faber, Kelley, Fields, Julie A., Fong, Jamie, Foroud, Tatiana M., Gavrilova, Ralitza H., Gearhart, Debra, Ghoshal, Nupur, Goldman, Jill, Graff-Radford, Jonathan, Graff-Radford, Neill R., Grossman, Murray, Haley, Dana, Heuer, Hilary W., Hsiao, John, Robin Hsiung, Ging-Yuek, Huey, Edward D., Irwin, David J., Jones, David T., Jones, Lynne, Kantarci, Kejal, Karydas, Anna M., Knopman, David S., Kornak, John, Kramer, Joel H., Kremers, Walter K., Kukull, Walter A., Lapid, Maria I., Lucente, Diane, Mackenzie, Ian R., Manoochehri, Masood, McGinnis, Scott M., Miller, Bruce L., Pearlman, Rodney, Petrucelli, Leonard, Potter, Madeline, Rademakers, Rosa, Rankin, Katherine, Rascovsky, Katya, Sengdy, Pheth, Shaw, Leslie M., Sutherland, Marg, Syrjanen, Jeremy, Tatton, Nadine, Taylor, Joanne, Toga, Arthur W., Trojanowski, John Q., Weintraub, Sandra, Wong, Bonnie, and Wszolek, Zbigniew

Published
2018
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39. THE NIH-EXAMINER IS SENSITIVE TO COGNITIVE CHANGES IN ASYMPTOMATIC AND MILDLY SYMPTOMATIC FAMILIAL FRONTOTEMPORAL DEMENTIA

Author

Staffaroni, Adam M., Bajorek, Lynn, Ljubenkov, Peter, Casaletto, Kaitlin, Elahi, Fanny, Rascovsky, Katya, Boeve, Bradley F., Boxer, Adam L., Bove, Jessica, Brushaber, Danielle, Coppola, Giovanni, Dheel, Christina, Dickerson, Brad C., Fields, Julie A., Fong, Jamie, Forsberg, Leah K., Gavrilova, Ralitza H., Gearhart, Debra, Ghoshal, Nupur, Goldman, Jill, Radford, Jonathan Graff, Graff-Radford, Neill R., Grossman, Murray, Haley, Dana, Heuer, Hilary W., Hsiao, John, Robin Hsiung, Ging-Yuek, Huey, Edward, Irwin, David J., Jones, David T., Jones, Lynne, Kantarci, Kejal, Karydas, Anna M., Knopman, David S., Kornak, John, Kremers, Walter K., Kukull, Walter A., Lapid, Maria I., Lucente, Diane, Mackenzie, Ian R., Manoochehri, Masood, Miller, Bruce L., Potter, Madeline, Rademakers, Rosa, Rankin, Katherine, Sutherland, Margaret, Syrjanen, Jeremy, Taylor, Joanne, Weintraub, Sandra, Wong, Bonnie, Wszolek, Zbigniew, Rosen, Howard J., and Kramer, Joel H.

Published
2018
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40. MR SPECTROSCOPY FROM FRONTAL LOBE AND POSTERIOR CINGULATE GYRUS IN ASYMPTOMATIC AND SYMPTOMATIC MICROTUBULE-ASSOCIATED PROTEIN TAU (MAPT) MUTATION CARRIERS

Author

Chen, Qin, Boeve, Bradley F., Brushaber, Danielle, Dheel, Christina, Fields, Julie A., Forsberg, Leah K., Gavrilova, Ralitza H., Gearhart, Debra, Haley, Dana, Graff-Radford, Jonathan, Jones, David T., Knopman, David S., Graff-Radford, Neill R., Kraft, Ruth A., Lapid, Maria I., Rademakers, Rosa, Syrjanen, Jeremy, Wszolek, Zbigniew, Rosen, Howard J., Boxer, Adam L., and Kantarci, Kejal

Published
2018
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41. USING A BRAIN NETWORK APPROACH TO PREDICT GENETIC MUTATION IN INDIVIDUAL PATIENTS WITH FAMILIAL FRONTOTEMPORAL DEMENTIA

Author

Touroutoglou, Alexandra, Brickhouse, Michael, Krivensky, Samantha, Wong, Bonnie, Getchell, Katelynn, Lucente, Diane, McGinnis, Scott M., Dickerson, Brad C., Boeve, Bradley F., Rosen, Howard J., Boxer, Adam L., Bove, Jessica, Brushaber, Danielle, Coppola, Giovanni, Dheel, Christina, Dickinson, Susan, Faber, Kelley, Fields, Julie A., Fong, Jamie, Foroud, Tatiana, Forsberg, Leah K., Gavrilova, Ralitza H., Gearhart, Debra, Ghoshal, Nupur, Goldman, Jill, Graff-Radford, Jonathan, Graff-Radford, Neill R., Grossman, Murray, Haley, Dana, Heuer, Hilary W., Hsiao, John, Huey, Edward, Irwin, David, Jones, David T., Jones, Lynne, Kantarci, Kejal, Karydas, Anna M., Knopman, David S., Kornak, John, Kramer, Joel H., Kremers, Walter K., Kukull, Walter A., Lapid, Maria I., Mackenzie, Ian R., Manoochehri, Masood, Miller, Bruce L., Pearlman, Rodney, Potter, Madeline, Rademakers, Rosa, Rankin, Katherine, Rascovsky, Katya, Sengdy, Pheth, Shaw, Leslie M., Sutherland, Margaret, Syrjanen, Jeremy, Tatton, Nadine, Taylor, Joanne, Toga, Arthur W., Trojanowski, John Q., Weintraub, Sandra, and Wszolek, Zbigniew

Published
2018
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42. ACCELERATED NEUROCHEMICAL CHANGES PRIOR TO PHENOCONVERSION TO FRONTOTEMPORAL LOBAR DEGENERATION IN PRESYMPTOMATIC MICROTUBULE-ASSOCIATED PROTEIN TAU (MAPT) MUTATION CARRIERS: A LONGITUDINAL MRS STUDY

Author

Chen, Qin, Boeve, Bradley F., Tosakulwong, Nirubol, Lesnick, Timothy G., Brushaber, Danielle, Dheel, Christina, Fields, Julie A., Forsberg, Leah K., Gavrilova, Ralitza H., Gearhart, Debra, Haley, Dana, Gunter, Jeffrey L., Graff-Radford, Jonathan, Jones, David T., Knopman, David S., Graff-Radford, Neill R., Kraft, Ruth A., Lapid, Maria I., Rademakers, Rosa, Syrjanen, Jeremy, Wszolek, Zbigniew, Rosen, Howard J., Boxer, Adam L., and Kantarci, Kejal

Published
2018
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43. NONLINEAR N-SCORE ESTIMATION FOR ESTABLISHING COGNITIVE NORMS FROM THE NATIONAL ALZHEIMER’S COORDINATING CENTER (NACC) DATASET

Author

Kornak, John, Fields, Julie A., Farmer, Sarah, Boeve, Bradley F., Rosen, Howard J., Boxer, Adam L., Bove, Jessica, Brushaber, Danielle, Coppola, Giovanni, Dheel, Christina, Dickerson, Brad C., Dickinson, Susan, Faber, Kelley, Fong, Jamie, Foroud, Tatiana M., Forsberg, Leah K., Gavrilova, Ralitza H., Gearhart, Debra, Ghoshal, Nupur, Goldman, Jill, Graff-Radford, Jonathan, Graff-Radford, Neill R., Grossman, Murray, Haley, Dana, Heuer, Hilary W., Hsiao, John, Robin Hsiung, Ging-Yuek, Huey, Edward D., Irwin, David, Jones, David T., Jones, Lynne, Kantarci, Kejal, Karydas, Anna M., Knopman, David S., Kramer, Joel H., Kremers, Walter K., Kukull, Walter A., Lapid, Maria I., Lucente, Diane, Mackenzie, Ian R., Manoochehri, Masood, Miller, Bruce L., Pearlman, Rodney, Petrucelli, Leonard, Potter, Madeline, Rademakers, Rosa, Rankin, Katherine, Rascovsky, Katya, Sengdy, Pheth, Shaw, Leslie M., Sutherland, Margaret, Syrjanen, Jeremy, Tatton, Nadine, Taylor, Joanne, Toga, Arthur W., Trojanowski, John Q., Weintraub, Sandra, Wong, Bonnie, and Wszolek, Zbigniew

Published
2018
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44. Rates of lobar atrophy in asymptomatic MAPTmutation carriers

Author

Chen, Qin, Boeve, Bradley F., Senjem, Matthew, Tosakulwong, Nirubol, Lesnick, Timothy G., Brushaber, Danielle, Dheel, Christina, Fields, Julie, Forsberg, Leah, Gavrilova, Ralitza, Gearhart, Debra, Graff-Radford, Jonathan, Graff-Radford, Neill R., Jack, Clifford R., Jones, David T., Knopman, David S., Kremers, Walter K., Lapid, Maria, Rademakers, Rosa, Syrjanen, Jeremy, Boxer, Adam L., Rosen, Howie, Wszolek, Zbigniew K., Kantarci, Kejal, Coppola, Giovanni, Dickerson, Bradford C., Dickinson, Susan, Faber, Kelly, Fong, Jamie, Foroud, Tatiana, Ghoshal, Nupur, MurrayGrossman, Jill Goldman, Heuer, HilaryW., Hsiao, John, Hsiung, Ging-Yuek R., Huey, Edward, Irwin, David J., Karydas, Anna M., Kornak, John, Kramer, Joel, Kukull, Walter A., Lucente, Diane, Lungu, Codrin, Mackenzie, Ian R.A., McGinnis, Scott, Miller, Bruce L., Petrucelli, Leonard, Potter, Madeline, Ramos, Eliana M., Rankin, Katherine P., Rascovsky, Katya, Shaw, Leslie, Sutherland, Marg, Tatton, Nadine, Taylor, Joanne, Toga, Arthur W., Trojanowski, John, Weintraub, Sandra, and Wong, Bonnie

Abstract

The aim of this study was to investigate the rates of lobar atrophy in the asymptomatic microtubule-associated protein tau (MAPT) mutation carriers.

Published
2019
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48. Chronic, Intermittent Exposure to Chlorpyrifos in Rats: Protracted Effects on Axonal Transport, Neurotrophin Receptors, Cholinergic Markers, and Information Processing

Author

Terry, Alvin V., primary, Gearhart, Debra A., additional, Beck, Wayne D., additional, Truan, Jacob N., additional, Middlemore, Mary-Louise, additional, Williamson, Leah N., additional, Bartlett, Michael G., additional, Prendergast, Mark A., additional, Sickles, Dale W., additional, and Buccafusco, Jerry J., additional

Published
2007
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