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19. 3rd EACTS Meeting on Cardiac and Pulmonary Regeneration Berlin-Brandenburgische Akademie, Berlin, Germany, 14-15 December 2012

Author

Bader, A, Brodarac, A, Hetzer, R, Kurtz, A, Stamm, C, Baraki, H, Kensah, G, Asch, S, Rojas, S, Martens, A, Gruh, I, Haverich, A, Kutschka, I, Cortes Dericks, L, Froment, L, Kocher, G, Schmid, Ra, Delyagina, E, Schade, A, Scharfenberg, D, Skorska, A, Lux, C, Li, W, Steinhoff, G, Drey, F, Lepperhof, V, Neef, K, Fatima, A, Wittwer, T, Wahlers, T, Saric, T, Choi, Yh, Fehrenbach, D, Lehner, A, Herrmann, F, Hollweck, T, Pfeifer, S, Wintermantel, E, Kozlik Feldmann, R, Hagl, C, Akra, B, Gyöngyösi, M, Zimmermann, M, Pavo, N, Mildner, M, Lichtenauer, M, Maurer, G, Ankersmit, J, Hacker, S, Mittermayr, R, Haider, T, Nickl, S, Beer, L, Lebherz Eichinger, D, Schweiger, T, Mitterbauer, A, Keibl, C, Werba, G, Frey, M, Ankersmit, Hj, Herrmann, S, Lux, Ca, Holfeld, J, Tepeköylü, C, Wang, Fs, Kozaryn, R, Schaden, W, Grimm, M, Wang, Cj, Urbschat, A, Zacharowski, K, Paulus, P, Avaca, Mj, Kempf, H, Malan, D, Sasse, P, Fleischmann, B, Palecek, J, Dräger, G, Kirschning, A, Zweigerdt, R, Martin, U, Katsirntaki, K, Haller, R, Ulrich, S, Sgodda, M, Puppe, V, Duerr, J, Schmiedl, A, Ochs, M, Cantz, T, Mall, M, Mauritz, C, Lara, Ar, Dahlmann, J, Schwanke, K, Hegermann, J, Skvorc, D, Gawol, A, Azizian, A, Wagner, S, Krause, A, Klopsch, C, Gaebel, R, Kaminski, A, Chichkov, B, Jockenhoevel, S, Klose, K, Roy, R, Kang, Ks, Bieback, K, Nasseri, B, Polchynska, O, Kruttwig, K, Brüggemann, C, Xu, G, Baumgartner, A, Hasun, M, Podesser, Bk, Ludwig, M, Tölk, A, Noack, T, Margaryan, R, Assanta, N, Menciassi, Arianna, Burchielli, S, Matteucci, Marco, Lionetti, Vincenzo, Luchi, C, Cariati, E, Coceani, F, Murzi, B, Rojas, Sv, Rotärmel, A, Nasseri, Ba, Ebell, W, Dandel, M, Kukucka, M, Gebker, R, Mutlak, H, Ockelmann, P, Tacke, S, Scheller, B, Pereszlenyi, A, Meier, M, Schecker, N, Rathert, C, Becher, Pm, Drori Carmi, N, Bercovich, N, Zahavi Goldstein, E, Jack, M, Netzer, N, Pinzur, L, Chajut, A, Tschöpe, C, Ruch, U, Strauer, Be, Tiedemann, G, Schlegel, F, Dhein, S, Akhavuz, O, Mohr, Fw, Dohmen, Pm, Salameh, A, Oelmann, K, Kiefer, P, Merkert, S, Templin, C, Jara Avaca, M, Müller, S, von Haehling, S, Slavic, S, Curato, C, Altarche Xifro, W, Unger, T, Li, J, Zhang, Y, Li, Wz, Ou, L, Ma, N, Haase, A, Alt, R, and Martin, U.

Published
2013

26. 3rd EACTS Meeting on Cardiac and Pulmonary Regeneration Berlin-Brandenburgische Akademie, Berlin, Germany, 14-15 December 2012

Author

Bader, A., primary, Brodarac, A., additional, Hetzer, R., additional, Kurtz, A., additional, Stamm, C., additional, Baraki, H., additional, Kensah, G., additional, Asch, S., additional, Rojas, S., additional, Martens, A., additional, Gruh, I., additional, Haverich, A., additional, Kutschka, I., additional, Cortes-Dericks, L., additional, Froment, L., additional, Kocher, G., additional, Schmid, R. A., additional, Delyagina, E., additional, Schade, A., additional, Scharfenberg, D., additional, Skorska, A., additional, Lux, C., additional, Li, W., additional, Steinhoff, G., additional, Drey, F., additional, Lepperhof, V., additional, Neef, K., additional, Fatima, A., additional, Wittwer, T., additional, Wahlers, T., additional, Saric, T., additional, Choi, Y.- H., additional, Fehrenbach, D., additional, Lehner, A., additional, Herrmann, F., additional, Hollweck, T., additional, Pfeifer, S., additional, Wintermantel, E., additional, Kozlik-Feldmann, R., additional, Hagl, C., additional, Akra, B., additional, Gyongyosi, M., additional, Zimmermann, M., additional, Pavo, N., additional, Mildner, M., additional, Lichtenauer, M., additional, Maurer, G., additional, Ankersmit, J., additional, Hacker, S., additional, Mittermayr, R., additional, Haider, T., additional, Nickl, S., additional, Beer, L., additional, Lebherz-Eichinger, D., additional, Schweiger, T., additional, Mitterbauer, A., additional, Keibl, C., additional, Werba, G., additional, Frey, M., additional, Ankersmit, H. J., additional, Herrmann, S., additional, Lux, C. A., additional, Holfeld, J., additional, Tepekoylu, C., additional, Wang, F.- S., additional, Kozaryn, R., additional, Schaden, W., additional, Grimm, M., additional, Wang, C.- J., additional, Urbschat, A., additional, Zacharowski, K., additional, Paulus, P., additional, Avaca, M. J., additional, Kempf, H., additional, Malan, D., additional, Sasse, P., additional, Fleischmann, B., additional, Palecek, J., additional, Drager, G., additional, Kirschning, A., additional, Zweigerdt, R., additional, Martin, U., additional, Katsirntaki, K., additional, Haller, R., additional, Ulrich, S., additional, Sgodda, M., additional, Puppe, V., additional, Duerr, J., additional, Schmiedl, A., additional, Ochs, M., additional, Cantz, T., additional, Mall, M., additional, Mauritz, C., additional, Lara, A. R., additional, Dahlmann, J., additional, Schwanke, K., additional, Hegermann, J., additional, Skvorc, D., additional, Gawol, A., additional, Azizian, A., additional, Wagner, S., additional, Krause, A., additional, Klopsch, C., additional, Gaebel, R., additional, Kaminski, A., additional, Chichkov, B., additional, Jockenhoevel, S., additional, Klose, K., additional, Roy, R., additional, Kang, K.- S., additional, Bieback, K., additional, Nasseri, B., additional, Polchynska, O., additional, Kruttwig, K., additional, Bruggemann, C., additional, Xu, G., additional, Baumgartner, A., additional, Hasun, M., additional, Podesser, B. K., additional, Ludwig, M., additional, Tolk, A., additional, Noack, T., additional, Margaryan, R., additional, Assanta, N., additional, Menciassi, A., additional, Burchielli, S., additional, Matteucci, M., additional, Lionetti, V., additional, Luchi, C., additional, Cariati, E., additional, Coceani, F., additional, Murzi, B., additional, Rojas, S. V., additional, Rotarmel, A., additional, Nasseri, B. A., additional, Ebell, W., additional, Dandel, M., additional, Kukucka, M., additional, Gebker, R., additional, Mutlak, H., additional, Ockelmann, P., additional, Tacke, S., additional, Scheller, B., additional, Pereszlenyi, A., additional, Meier, M., additional, Schecker, N., additional, Rathert, C., additional, Becher, P. M., additional, Drori-Carmi, N., additional, Bercovich, N., additional, Zahavi-Goldstein, E., additional, Jack, M., additional, Netzer, N., additional, Pinzur, L., additional, Chajut, A., additional, Tschope, C., additional, Ruch, U., additional, Strauer, B.- E., additional, Tiedemann, G., additional, Schlegel, F., additional, Dhein, S., additional, Akhavuz, O., additional, Mohr, F. W., additional, Dohmen, P. M., additional, Salameh, A., additional, Oelmann, K., additional, Kiefer, P., additional, Merkert, S., additional, Templin, C., additional, Jara-Avaca, M., additional, Muller, S., additional, von Haehling, S., additional, Slavic, S., additional, Curato, C., additional, Altarche-Xifro, W., additional, Unger, T., additional, Li, J., additional, Zhang, Y., additional, Li, W. Z., additional, Ou, L., additional, Ma, N., additional, Haase, A., additional, and Alt, R., additional

Published
2013
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33. The role of dobutamine stress cardiovascular magnetic resonance in the clinical management of patients with suspected and known coronary artery disease.

Author

Gebker R, Jahnke C, Manka R, Hucko T, Schnackenburg B, Kelle S, Klein C, Fleck E, and Paetsch I

Abstract

BACKGROUND: Recent studies have demonstrated the consistently high diagnostic and prognostic value of dobutamine stress cardiovascular magnetic resonance (DCMR). The value of DCMR for clinical decision making still needs to be defined. Hence, the purpose of this study was to assess the utility of DCMR regarding clinical management of patients with suspected and known coronary artery disease (CAD) in a routine setting. METHODS AND RESULTS: We prospectively performed a standard DCMR examination in 1532 consecutive patients with suspected and known CAD. Patients were stratified according to the results of DCMR: DCMR-positive patients were recommended to undergo invasive coronary angiography and DCMR-negative patients received optimal medical treatment. Of 609 (40%) DCMR-positive patients coronary angiography was performed in 478 (78%) within 90 days. In 409 of these patients significant coronary stenoses ?50% were present (positive predictive value 86%). Of 923 (60%) DCMR-negative patients 833 (90%) received optimal medical therapy. During a mean follow-up period of 2.1 ± 0.8 years (median: 2.1 years, interquartile range 1.5 to 2.7 years) 8 DCMR-negative patients (0.96%) sustained a cardiac event.In 131 DCMR-positive patients who did not undergo invasive angiography, 20 patients (15%) suffered cardiac events. In 90 DCMR-negative patients (10%) invasive angiography was performed within 2 years (range 0.01 to 2.0 years) with 56 patients having coronary stenoses ?50%. CONCLUSION: In a routine setting DCMR proved a useful arbiter for clinical decision making and exhibited high utility for stratification and clinical management of patients with suspected and known CAD. [ABSTRACT FROM AUTHOR]

Published
2011

35. Abstracts

Author

Doulaptsis, C, Masci, PG, Goetschalckx, K, Janssens, S, Bogaert, J, Ferreira, VM, Piechnik, SK, DallArmellina, E, Karamitsos, TD, Francis, JM, Ntusi, N, Holloway, C, Choudhury, RP, Kardos, A, Robson, MD, Friedrich, MG, Neubauer, S, Miszalski-Jamka, T, Sokolowska, B, Szczeklik, W, Karwat, K, Miszalski-Jamka, K, Belzak, K, Malek, L, Mazur, W, Kereiakes, DJ, Jazwiec, P, Musial, J, Pedrotti, P, Masciocco, G, DAngelo, L, Milazzo, A, Quattrocchi, G, Zanotti, F, Frigerio, M, Roghi, A, Rimoldi, O, Kaasalainen, T, Kivistö, S, Holmström, M, Pakarinen, S, Hänninen, H, Sipilä, O, Lauerma, K, Banypersad, S.M, Fontana, M, Maestrini, V, Sado, D.M, Pinney, J, Wechalekar, A.D, Gillmore, J.D, Lachmann, H, Hawkins, P.N, Moon, J.C, Barone-Rochette, G, Pierard, S, Seldrum, S, de Ravensteen, CM, Melchior, J, Maes, F, Pouleur, A-C, Vancraeynest, D, Pasquet, A, Vanoverschelde, J-L, L Gerber, B, Captur, G, Muthurangu, V, Flett, AS, Wilson, R, Barison, A, Anderson, S, Cook, C, Sado, DM, McKenna, WJ, Mohun, TJ, Elliott, PM, Moon, JC, Pepe, A, Meloni, A, Gulino, L, Rossi, G, Paci, C, Spasisno, A, keilberg, P, Restaino, G, Resta, MC, Positano, V, lombardi, M, Reiter, U, Reiter, G, Kovacs, G, Schmidt, A, Olschewski, H, Fuchsjäger, M, Macmillan, A, Dabir, D, Rogers, T, Monaghan, M, Nagel, E, Puntmann, V, Semaan, E, Spottiswoode, B, Freed, B, Carr, M, Wasielewski, M, Fortney-Campione, K, Shah, S, Carr, J, Markl, M, Collins, J, Sung, YM, Hinojar, R, Ucar, EA, Dabir, D, Voigt, T, Gaddum, N, Schaeffter, T, Nagel, E, Puntmann, VO, Dabir, D, Rogers, T, Ucar, EA, Kidambi, A, Plein, S, Gebker, R, Schnackenburg, B, Voigt, T, Schaeffter, T, Nagel, E, Puntmann, VO, McAlindon, E, Bucciarelli-Ducci, C, Sado, D, Maestrini, V, Piechnik, S, Porter, J, Yamamura, J, Fischer, R, Moon, J, Symons, R, Doulaptsis, C, Masci, P.G, Goetschalckx, K, Dymarkowski, S, Janssens, S, Bogaert, J, Yalin, K, Golcuk, E, Ozer, CS, Buyukbayrak, H, Yilmaz, R, Dursun, M, Bilge, AK, Adalet, K, Reinstadler, SJ, Klug, G, Feistritzer, HJ, Mayr, A, Harrasser, B, Krauter, L, Mair, J, Schocke, MF, Pachinger, O, Metzler, B, Rigolli, M, To, A, Edwards, C, Ding, P, Christiansen, J, Rodríguez-Palomares, JF, Ortiz, JT, Bucciarelli, C, Lee, D, Wu, E, Bonow, RO, Karwat, K, Tomala, M, Miszalski-Jamka, K, Licholaj, S, Mazur, W, Kereiakes, DJ, Nessler, J, Zmudka, K, Jazwiec, P, Miszalski-Jamka, T, Peltonen, J, Kaasalainen, T, Kivistö, S, Holmström, M, Lauerma, K, Rutz, T, Meierhofer, C, Martinoff, S, Ewert, P, Hess, J, Stern, H, Fratz, S, Groarke, JD, Waller, AH, Blankstein, R, Kwong, RY, Steigner, M, Alizadeh, Z, Alizadeh, A, Khajali, Z, Mohammadzadeh, A, Kaykhavani, A, Heidarali, M, Singh, A, Bekele, S, Gunarathne, A, Khan, J, Nazir, SN, Steadman, CD, Kanagala, P, Horsfield, MA, McCann, GP, Duncan, RF, Dundon, BK, Nelson, AJ, Williams, K, Carbone, A, Worthley, MI, Zaman, A, Worthley, SG, Monney, P, Piccini, D, Rutz, T, Vincenti, G, Koestner, S, Stuber, M, Schwitter, J, Gripari, P, Maffessanti, F, Pontone, G, Andreini, D, Bertella, E, Mushtaq, S, Caiani, EG, Pepi, M, El ghannudi, S, Nghiem, A, Germain, P, Jeung, M-J, Roy, C, Gangi, A, Nucifora, G, Muser, D, Masci, PG, Barison, A, Piccoli, G, Rebellato, L, Puppato, M, Gasparini, D, Lombardi, M, Proclemer, A, Nucifora, G, Muser, D, Masci, PG, Barison, A, Piccoli, G, Rebellato, L, Puppato, M, Gasparini, D, Lombardi, M, Proclemer, A, Pöyhönen, P, Kivistö, S, Holmströn, M, Hänninen, H, Thorning, C, Bickelhaupt, S, Kampmann, C, Wentz, KU, Widmer, U, Juli, CF, Miszalski-Jamka, K, Klys, J, Glowacki, J, Kijas, M, Miszalski-Jamka, T, Adamczyk, T, Kwiecinski, R, Bogucka-Czapska, J, Ozaist, M, Mazur, W, Kluczewska, E, Kalarus, Z, Kukulski, T, Karakus, G, Marzluf, B, Bonderman, D, Tufaro, C, Pfaffenberger, S, Babyev, J, Maurer, G, Mascherbauer, J, Kockova, R, Tintera, J, Kautznerova, D, Cerna, D, Sedlacek, K, Kryze, L, El-Husseini, W, Sikula, V, Segetova, M, Kautzner, J, Vasconcelos, M, Lebreiro, A, Martins, E, Cardoso, JS, Madureira, AJ, Ramos, I, Maciel, MJ, Florian, A, Ludwig, A, Rösch, S, Sechtem, U, Yilmaz, A, Monmeneu, J.V, López-Lereu, M.P, Bonanad, C, Sanchis, J, Chaustre, F, Merlos, P, Valero, E, Bodí, V, Chorro, F.J, Yalin, K, Golcuk, E, Ozer, CS, Buyukbayrak, H, Yilmaz, R, Dursun, M, Bilge, AK, Adalet, K, Klug, G, Reinstadler, SJ, Feistritzer, HJ, Mayr, A, Riegler, N, Schocke, M, Esterhammer, R, Kremser, C, Pachinger, O, Metzler, B, Siddiqi, N, Cameron, D, Neil, C, Jagpal, B, Singh, S, Schwarz, K, Papadopoulou, S, Frenneaux, MP, Dawson, D, Robbers, LFHJ, Eerenberg, ES, Teunissen, PFA, Jansen, MF, Hollander, MR, Horrevoets, AJG, Knaapen, P, Nijveldt, R, Levi, MM, van Rossum, AC, Niessen, HWM, Marcu, CB, Beek, AM, van Royen, N, Everaars, H, Robbers, LFHJ, Nijveldt, R, Beek, AM, Teunissen, PFA, Hirsch, A, van Royen, N, Zijlstra, F, Piek, JJ, van Rossum, AC, Goitein, O, Grupper, A, Hamdan, A, Eshet, Y, Beigel, R, Medvedofsky, D, Herscovici, R, Konen, E, Hod, H, Matetzky, S, Cadenas, R, Iniesta, AM, Refoyo, E, Antorrena, I, Guzman, G, Cuesta, E, Salvador, O, López, T, Moreno, M, López-Sendon, JL, Alam, SR, Spath, N, Richards, J, Dweck, M, Shah, A, Lang, N, Semple, S, MacGillivray, T, Mckillop, G, Mirsadraee, S, Pessotto, R, Zamvar, V, Newby, DE, Henriksen, P, Reiter, G, Reiter, U, Kovacs, G, Olschewski, H, Fuchsjäger, M, Ahmad, S, Raza, U, Malik, A, Sun, JP, Eisner, R, Mazur, W, ODonnell, R, Positano, V, Meloni, A, Santarelli, MF, Landini, L, Tassi, C, Grimaldi, S, Gulino, L, De Marchi, D, Chiodi, E, Renne, S, Lombardi, M, Pepe, A, Wu, L, Germans, T, Güçlü, A, Allaart, CP, van Rossum, AC, Kalisz, K, Lehenbauer, K, Katz, D, Bi, X, Cordts, M, Guetter, C, Jolly, M-P, Freed, B, Shah, S, Markl, M, Flukiger, J, Carr, J, Collins, J, Osiak, A, Tyrankiewicz, U, Jablonska, M, Jasinski, K, Jochym, PT, Chlopicki), S, Skorka, T, Kalisz, K, Semaan, E, Katz, D, Bi, X, Cordts, M, Guetter, C, Jolly, MP, Freed, B, Flukiger, J, Lee, D, Kansal, P, Shah, S, Markl, M, Carr, J, Collins, J, Groarke, JD, Shah, RV, Waller, AH, Abbasi, SA, Kwong, RY, Blankstein, R, Steigner, M, Chin, CWL, Semple, S, Malley, T, White, A, Prasad, S, Newby, DE, Dweck, M, Pepe, A, Meloni, A, Lai, ME, Vaquer, S, Gulino, L, De Marchi, D, Cuccia, L, Midiri, M, Vallone, A, Positano, V, Lombardi, M, Pedrotti, P, Milazzo, A, Quattrocchi, G, Roghi, A, Rimoldi, O, Barison, A, De Marchi, D, Masci, P, Milanesi, M, Aquaro, GD, Keilberg, P, Positano, V, Lombardi, M, Positano, Vincenzo, Barison, Andrea, Pugliese, Nicola Riccardo, Masci, Piergiorgio, Del Franco, Annamaria, Aquaro, Giovanni Donato, Landini, Luigi, Lombardi, Massimo, Dieringer, MA, Deimling, M, Fuchs, K, Winter, L, Kraus, O, Knobelsdorff-Brenkenhoff, FV, Schulz-Menger, J, Niendorf, T, Hinojar, R, Ucar, EA, DCruz, D, Sangle, S, Dabir, D, Voigt, T, Gaddum, N, Schaeffter, T, Nagel, E, Puntmann, VO, Sung, YM, Pontone, G, Andreini, D, Bertella, E, Mushtaq, S, Gripari, P, Cortinovis, S, Loguercio, M, Baggiano, A, Conte, E, Pepi, M, El ghannudi, S, Hop, O, Germain, P, Jeung, M-J, De Cesare, A, Roy, C, Gangi, A, Barone-Rochette, G, Pierard, S, Seldrum, S, De Meester de Ravensteen, C, Melchior, J, Maes, F, Pouleur, A-C, Vancraeynest, D, Pasquet, A, Vanoverschelde, J-L, L Gerber, B, Bekele, S, Singh, A, Khan, JN, Nazir, SA, Kanagala, P, McCann, GP, Singh, A, Steadman, CD, Bekele, S, Khan, JN, Nazir, SA, Kanagala, P, McCann, GP, Paelinck, BP, Vandendriessche, T, De Bock, D, De Maeyer, C, Parizel, PM, Christiaan, J, Trauzeddel, RF, Gelsinger, C, Butter, C, Barker, A, Markl, M, Schulz-Menger, J, von Knobelsdorff, F, Florian, A, Schäufele, T, Ludwig, A, Rösch, S, Wenzelburger, I, Yilmaz, A, Sechtem, U, López-Lereu, M.P, Bonanad, C, Monmeneu, J.V, Sanchís, J, Estornell, J, Igual, B, Maceira, A, Chorro, F.J, Focardi, M, Cameli, M, Bennati, E, Massoni, A, Solari, M, Carbone, F, Banchi, B, Mondillo, S, Miia, H, Kirsi, L, Helena, H, Tiina, H, Jyri, L, Pauli, P, Sari, K, Schumm, J, Greulich, S, Grün, S, Ong, P, Klingel, K, Kandolf, R, Sechtem, U, Mahrholdt, H, Raimondi, F, Ou, P, Boudjemline, Y, Bajolle, F, Iserin, F, Bonnet, D, Collins, J, Kalisz, K, Benefield, B, Sarnari, R, Katz, D, Bi, X, Cordts, M, Guetter, C, Jolly, M-P, Freed, B, Flukiger, J, Kansal, P, Lee, D, Shah, S, Markl, M, Carr, J, Sokolowska, B, Miszalski-Jamka, T, Szczeklik, W, Karwat, K, Miszalski-Jamka, K, Belzak, K, Mazur, W, Kereiakes, DJ, Jazwiec, P, Musial, J, Silva, G, Almeida, AG, Resende, C, Marques, JS, Silva, D, David, C, Amaro, C, Costa, P, Silva, JAP, Diogo, AN, Tsokolov, AV, Senchilo, VG, Vertelkin, AV, Hoffmann, P, Mykjåland, G, Wangberg, H, Tønnessen, T, Sjaastad, I, Nordsletten, L, Hjørnholm, U, Løset, A, Rostrup, M, Meloni, A, Gulino, L, Keilberg, P, Palazzi, G, Maddaloni, D, Ascioti, C, Missere, M, Salvatori, C, Positano, V, Lombardi, M, Pepe, A, Meloni, A, Filosa, A, Gulino, L, Pulini, S, Salvatori, C, Chiodi, E, Ascioti, C, Keilberg, P, Positano, V, Lombardi, M, Pepe, A, Meloni, A, Gulino, L, Pietrapertosa, A, Izzi, G, De Marchi, D, Valeri, G, Preziosi, P, Positano, V, Lombardi, M, Pepe, A, Meloni, A, Ruffo, GB, Keilberg, P, Gulino, L, Gerardi, C, Sallustio, G, Tudisca, C, Positano, V, Lombardi, M, Pepe, A, Greulich, S, Backes, M, Schumm, J, Grün, S, Sechtem, U, Mahrholdt, H, Dorniak, K, MSc, AS, Szurowska, E, Fijalkowski, M, Rawicz-Zegrzda, D, Dudziak, M, Raczak, G, Hamdan, A, Baker, FA, Klein, M, Di Segni, E, Goitein, O, Fibisch, G, Konen, E, Müller-Bierl, B, Tanaka, K, Buls, N, Fierens, Y, van Cauteren, T, Willekens, I, van Laere, S, Luypaert, R, de Mey, J, Muzzarelli, S, Faragasso, E, Pedrazzini, G, Sürder, D, Pasotti, E, Moccetti, T, Faletra, F, Qayyum, AA, Hasbak, P, Larsson, HB, Mathiasen, AB, Vejlstrup, NG, Kjaer, A, Kastrup, J, Moschetti, K, Favre, D, Pinget, C, Pilz, G, Petersen, S, Wagner, A, Wasserfallen, JB, Schwitter, J, Ghosh Dastidar, A, Cengarle, M, McAlindon, E, Augustine, D, Nightingale, AK, Bucciarelli-Ducci, C, Dandekar, VK, Ertel, AW, Dickens, C, Gonzalez, RC, Farzaneh-Far, A, Ripley, DP, Higgins, D, McDiarmid, AK, Bainbridge, GJ, Uddin, A, Kidambi, A, Herzog, B, Greenwood, JP, Plein, S, Khanji, M, Newton, T, Westwood, M, Sekhri, N, and Petersen, SE

Abstract

Background-Aims: Early post-infarction pericardial injury is a common finding but its diagnosis remains elusive. Though C-reactive protein (CRP) is considered a marker of myocardial damage, reflecting myocardial inflammation at the infarcted area, we sought to assess the relationship between CRP and pericardial injury depicted by cardiovascular magnetic resonance (CMR) imaging in patients with ST elevation myocardial infarction (MI). Methods and results: 181 MI patients (84% male) were studied with CMR in the first week and at 4 months post-infarction to assess infarct characteristics, left ventricular volumes/function and pericardial injury. The latter was defined as pericardial fluid >4mm and/or enhancement on late gadolinium enhancement CMR. The CRP-value at day 2 (according to previous literature) was used for correlation with CMR and clinical parameters. Pericardial injury was noted in 87 patients, i.e. effusion (n = 30), inflammation (n = 46), both (n = 11). Patients with pericardial injury had significantly higher peak values of cardiac biomarkers (p<0.001) and higher peak CRP-values than patients with normal pericardium (median 13 vs 43 mg/dl, p<0.001). A strong correlation was found between peak CRP-values and a) left venticular ejection fraction and infarct size both at 1 week and 4 months, b) myocardial hemorrhage, microvascular obstruction (MVO) and pericardial injury at 1 week, c) cardiac biomarkers values and time to PCI. However in a multiple regression model only pericardial injury (p = 0.003) and less importantly time to PCI (p = 0.022) were the independent predictors of CRP values. Conclusion: Pericardial damage described by cardiac MRI occurs often after acute ST elevation MI. CRP-values at the acute phase of MI reflect not only inflammation at the infarcted area but even more the inflammation of the surrounding pericardial tissue. Table 1 Comparison of baseline clinical and biochemical parameters of patients with or without evidence of early post-infarct pericardial damage on CMR Normal Group (n = 94)Pericardial injury group (n = 87)p-valueAgem, years59±1160±120.48Male, n(%)83 (88)69 (79)0.10Diabets, n(%)12 (13)9 (10)0.61Smoker, n(%)52 (55)44 (51)0.52Hyperlipidemia, n(%)56 (60)55 (63)0.62BSA m22.0 ± 0.22.0 ± 0.20.20Time to PCI, min195 (155 − 274)223 (160 − 335)0.20Troponin I, μ/l44 (19 − 92)90 (44 − 149)>0.001CK-MB, U/L128 (77 − 216)250 (143 − 443)>0.001CRP, mg/dL13 (7 − 28)43 (16 − 96)>0.001Day of peak CRP2 (1 − 3)2 (1 − 3)0.39 Table 2 Significant correlations between CRP Values and corresponding CMR measurements, cardic biomarkers and clinical related parameters VariblesSpearmanscorrelations rp-valueCMR parameters 1 weekLV EF−0.28>0,001Infractsize(%ofLV)0.40>0,001Microvasular obstruction0.27>0,001Hemorrhage0.33>0,001Size of area atrisk0.31>0,001Transmurality0.30>0,001Pericaldial damage0.43>0,001CMR parameters 4 monthsLVEF−0.43>0,001Infarctsize(%ofLV)0.46>0,001Cardiac BiomarkersPeak TnI0.34>0,001Peak CK-MB0.32>0,001OtherTime to PCI0,1820,007

Published
2013
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36. Range variability in cmr feature tracking multilayer strain across different stages of heart failure

Author

Radu Tanacli, Andreas Schuster, Tomas Lapinskas, Gianni Pedrizzetti, Burkert Pieske, Sebastian Kelle, Eike Nagel, Hans-Dirk Düngen, Frank Edelmann, Djawid Hashemi, Rolf Gebker, Tanacli, R., Hashemi, D., Lapinskas, T., Edelmann, F., Gebker, R., Pedrizzetti, G., Schuster, A., Nagel, E., Pieske, B., Dungen, H. -D., and Kelle, S.

Subjects
Male, Contraction (grammar), 616.12-008.46 [udc], lcsh:Medicine, 030204 cardiovascular system & hematology, 030218 nuclear medicine & medical imaging, 0302 clinical medicine, Risk Factors, Image Processing, Computer-Assisted, Longitudinal Studies, Prospective Studies, lcsh:Science, cardiac deformation, Multidisciplinary, Ejection fraction, Cardiac cycle, Middle Aged, Magnetic Resonance Imaging, Cardiac hypertrophy, Cardiology, cardiovascular mechanics, cardiac imaging, Female, medicine.medical_specialty, Heart failure, Heart ventricles, physiopathology, Myocardium, pathology, Magnetic resonance imaging, cine, methods, cardiovascular mechanic, Article, 03 medical and health sciences, Heart Failure, Internal medicine, medicine, Humans, Decompensation, ddc:610, Ventricular remodeling, Aged, business.industry, lcsh:R, Stroke Volume, medicine.disease, Computational biology and bioinformatics, Feature tracking, lcsh:Q, Cardiac magnetic resonance, business
Abstract

Heart failure (HF) is associated with progressive ventricular remodeling and impaired contraction that affects distinctly various regions of the myocardium. Our study applied cardiac magnetic resonance (CMR) feature tracking (FT) to assess comparatively myocardial strain at 3 distinct levels: subendocardial (Endo-), mid (Myo-) and subepicardial (Epi-) myocardium across an extended spectrum of patients with HF. 59 patients with HF, divided into 3 subgroups as follows: preserved ejection fraction (HFpEF, N = 18), HF with mid-range ejection fraction (HFmrEF, N = 21), HF with reduced ejection fraction (HFrEF, N = 20) and a group of age- gender- matched volunteers (N = 17) were included. Using CMR FT we assessed systolic longitudinal and circumferential strain and strain-rate at Endo-, Myo- and Epi- levels. Strain values were the highest in the Endo- layer and progressively lower in the Myo- and Epi- layers respectively, this gradient was present in all the patients groups analyzed but decreased progressively in HFmrEF and further on in HFrEF groups. GLS decreased with the severity of the disease in all 3 layers: Normal > HFpEF > HFmrEF > HFrEF (Endo-: −23.0 ± 3.5 > −20.0 ± 3.3 > −16.4 ± 2.2 > −11.0 ± 3.2, p −17.5.0 ± 2.6 > −14.5 ± 2.1 > −9.6 ± 2.7, p −12.2 ± 2.1 > −10.6 ± 2.3 > −7.7 ± 2.3, p HFmrEF > HFrEF (Endo-: −34.5 ± 6.2 > −20.0 ± 4.2 > 12.3 ± 4.2, p −13.0 ± 3.4 > −8.0 ± 2.7. p −7.9 ± 2.3 > −4.5 ± 1.9. p

Published
2019

38. The Relationship Between EF and Strain Permits a More Accurate Assessment of LV Systolic Function

Author

Lukas Stoiber, Giovanni Tonti, Remigijus Zaliunas, Tomas Lapinskas, Gianni Pedrizzetti, Sebastian Kelle, Rolf Gebker, Burkert Pieske, Pedrizzetti, G., Lapinskas, T., Tonti, G., Stoiber, L., Zaliunas, R., Gebker, R., Pieske, B., and Kelle, S.

Subjects
medicine.medical_specialty, Validation study, Heart Diseases, Systole, Cardiac mechanics, Deformation imaging, Systolic function, 030204 cardiovascular system & hematology, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, Ventricular Dysfunction, Left, 0302 clinical medicine, Predictive Value of Tests, Internal medicine, medicine, Humans, Radiology, Nuclear Medicine and imaging, Retrospective Studies, Ejection fraction, medicine.diagnostic_test, business.industry, Models, Cardiovascular, Reproducibility of Results, Magnetic resonance imaging, Stroke Volume, Stroke volume, Cardiac mechanic, Magnetic Resonance Imaging, Cardiology, Cardiology and Cardiovascular Medicine, business
Abstract

Ejection fraction (EF) represents the reference clinical parameter for the assessment of left ventricular (LV) systolic function; however, descriptions based on EF alone are certainly incomplete, and several cardiac dysfunctional states present a preserved EF. Deformation imaging allows describing

Published
2019

39. Dobutamine stress magnetic resonance imaging for the detection of coronary artery disease in women

Author

Robert Manka, Eckart Fleck, Jesus G Mirelis, Cosima Jahnke, Ingo Paetsch, Thomas Hucko, Bernhard Schnackenburg, Ashraf Hamdan, Rolf Gebker, University of Zurich, and Gebker, R

Subjects
Male, medicine.medical_specialty, Cardiotonic Agents, Ischemia, 610 Medicine & health, Coronary Artery Disease, Coronary Angiography, Sensitivity and Specificity, 2705 Cardiology and Cardiovascular Medicine, 170 Ethics, Coronary artery disease, Sex Factors, Dobutamine, Internal medicine, medicine, Humans, 10237 Institute of Biomedical Engineering, Prospective Studies, Prospective cohort study, medicine.diagnostic_test, business.industry, Magnetic resonance imaging, Dobutamine stress, Middle Aged, medicine.disease, Stenosis, Circulatory system, 10209 Clinic for Cardiology, Cardiology, Female, Radiology, Cardiology and Cardiovascular Medicine, business, Magnetic Resonance Angiography, medicine.drug
Abstract

Background: Dobutamine stress magnetic resonance (DSMR) imaging represents an excellent imaging approach for the detection of coronary artery disease (CAD). However, most studies predominantly reported the utility of DSMR in men. Thus, we performed a comparative study to evaluate the diagnostic value of DSMR in men and women. Methods and results: High dose dobutamine/atropine stress magnetic resonance imaging was performed and evaluated regarding new or worsening wall motion abnormalities in 745 consecutive patients (204 women, 541 men). Invasive coronary angiography was performed within 30 days and served as the reference standard (≥70% stenosis). DSMR was technically successful and had diagnostic image quality in all patients except 2 women and 5 men (P=ns). In the absence of ischemia target heart rate was not reached in 9.3% of women and 8.5% of men (P ns) despite maximum pharmacologic infusion (1% and 2.2%, respectively, P=ns) or due to limiting side effects (8.3% and 6.3%, respectively, P=ns). Diagnostic values (sensitivity/specificity/accuracy) for the detection of significant coronary stenoses were similar for men (86%/83%/85%) and women (85%/86%/85%). There was no gender-based difference in regional diagnostic accuracy of DSMR for all 3 coronary vascular territories in patients with single-vessel CAD (81% vs. 81%, P=ns, respectively). Conclusion: The diagnostic capability of DSMR regarding the detection of hemodynamically relevant, obstructive CAD is gender-independent.

Published
2009

40. CineVN: Variational network reconstruction for rapid functional cardiac cine MRI.

Author

Vornehm M, Wetzl J, Giese D, Fürnrohr F, Pang J, Chow K, Gebker R, Ahmad R, and Knoll F

Abstract

Purpose: To develop a reconstruction method for highly accelerated cardiac cine MRI with high spatiotemporal resolution and low temporal blurring, and to demonstrate accurate estimation of ventricular volumes and myocardial strain in healthy subjects and in patients., Methods: The proposed method, called CineVN, employs a spatiotemporal Variational Network combined with conjugate gradient descent for optimized data consistency and improved image quality. The method is first evaluated on retrospectively undersampled cine MRI data in terms of image quality. Then, prospectively accelerated data are acquired in 18 healthy subjects both segmented over two heartbeats per slice as well as in real time with 1.6 mm isotropic resolution. Ventricular volumes and strain parameters are computed and compared to a compressed sensing reconstruction and to a conventional reference cine MRI acquisition. Lastly, the method is demonstrated in 46 patients and ventricular volumes and strain parameters are evaluated., Results: CineVN outperformed compressed sensing in image quality metrics on retrospectively undersampled data. Functional parameters and myocardial strain were the most accurate for CineVN compared to two state-of-the-art compressed sensing methods., Conclusion: Deep learning-based reconstruction using our proposed method enables accurate evaluation of cardiac function in real-time cine MRI with high spatiotemporal resolution. This has the potential to improve cardiac imaging particularly for patients with arrhythmia or impaired breath-hold capability., (© 2024 Siemens Healthineers AG and The Author(s). Magnetic Resonance in Medicine published by Wiley Periodicals LLC on behalf of International Society for Magnetic Resonance in Medicine.)

Published
2024
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41. In Vivo Fluorine Imaging Using 1.5 Tesla MRI for Depiction of Experimental Myocarditis in a Rodent Animal Model.

Author

Dietrich T, Bujak ST, Keller T, Schnackenburg B, Bourayou R, Gebker R, Graf K, and Fleck E

Abstract

The usefulness of perfluorocarbon nanoemulsions for the imaging of experimental myocarditis has been demonstrated in a high-field 9.4 Tesla MRI scanner. Our proof-of-concept study investigated the imaging capacity of PFC-based 19 F/ 1 H MRI in an animal myocarditis model using a clinical field strength of 1.5 Tesla. To induce experimental myocarditis, five male rats (weight ~300 g, age ~50 days) were treated with one application per week of doxorubicin (2 mg/kg BW) over a period of six weeks. Three control animals received the identical volume of sodium chloride 0.9% instead. Following week six, all animals received a single 4 ml injection of an 20% oil-in-water perfluorooctylbromide nanoemulsion 24 hours prior to in vivo 1 H/ 19 F imaging on a 1.5 Tesla MRI. After euthanasia, cardiac histology and immunohistochemistry using CD68/ED1 macrophage antibodies were performed, measuring the inflamed myocardium in μ m 2 for further statistical analysis to compare the extent of the inflammation with the 19 F-MRI signal intensity. All animals treated with doxorubicin showed a specific signal in the myocardium, while no myocardial signal could be detected in the control group. Additionally, the doxorubicin group showed a significantly higher SNR for 19 F and a stronger CD68/ED1 immunhistoreactivity compared to the control group. This proof-of-concept study demonstrates that perfluorocarbon nanoemulsions could be detected in an in vivo experimental myocarditis model at a currently clinically relevant field strength., Competing Interests: The authors declare that there is no conflict of interest regarding this publication., (Copyright © 2023 Thore Dietrich et al.)

Published
2023
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42. Diagnostic performance of 3D cardiac magnetic resonance perfusion in elderly patients for the detection of coronary artery disease as compared to fractional flow reserve.

Author

Károlyi M, Gotschy A, Polacin M, Plein S, Paetsch I, Jahnke C, Frick M, Gebker R, Alkadhi H, Kozerke S, and Manka R

Subjects
Humans, Male, Aged, Aged, 80 and over, Middle Aged, Severity of Illness Index, Coronary Angiography methods, Predictive Value of Tests, Perfusion, Magnetic Resonance Spectroscopy, Coronary Artery Disease diagnosis, Fractional Flow Reserve, Myocardial, Myocardial Perfusion Imaging methods, Coronary Stenosis
Abstract

Objectives: In patients of advanced age, the feasibility of myocardial ischemia testing might be limited by age-related comorbidities and falling compliance abilities. Therefore, we aimed to test the accuracy of 3D cardiac magnetic resonance (CMR) stress perfusion in the elderly population as compared to reference standard fractional flow reserve (FFR)., Methods: Fifty-six patients at age 75 years or older (mean age 79 ± 4 years, 35 male) underwent 3D CMR perfusion imaging and invasive coronary angiography with FFR in 5 centers using the same study protocol. The diagnostic accuracy of CMR was compared to a control group of 360 patients aged below 75 years (mean age 61 ± 9 years, 262 male). The percentage of myocardial ischemic burden (MIB) relative to myocardial scar burden was further analyzed using semi-automated software., Results: Sensitivity, specificity, and positive and negative predictive values of 3D perfusion CMR deemed similar for both age groups in the detection of hemodynamically relevant (FFR < 0.8) stenosis (≥ 75 years: 86%, 83%, 92%, and 75%; < 75 years: 87%, 80%, 82%, and 85%; p > 0.05 all). While MIB was larger in the elderly patients (15% ± 17% vs. 9% ± 13%), the diagnostic accuracy of 3D CMR perfusion was high in both elderly and non-elderly populations to predict pathological FFR (AUC: 0.906 and 0.866)., Conclusions: 3D CMR perfusion has excellent diagnostic accuracy for the detection of hemodynamically relevant coronary stenosis, independent of patient age., Key Points: • The increasing prevalence of coronary artery disease in elderly populations is accompanied with a larger ischemic burden of the myocardium as compared to younger individuals. • 3D cardiac magnetic resonance perfusion imaging predicts pathological fractional flow reserve in elderly patients aged ≥ 75 years with high diagnostic accuracy. • Ischemia testing with 3D CMR perfusion imaging has similarly high accuracy in the elderly as in younger patients and it might be particularly useful when other non-invasive techniques are limited by aging-related comorbidities and falling compliance abilities., (© 2022. The Author(s).)

Published
2023
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43. Long-term prognostic value of vasodilator stress cardiac magnetic resonance in patients with atrial fibrillation.

Author

Weiss KJ, Nasser SB, Bigvava T, Doltra A, Schnackenburg B, Berger A, Anker MS, Stehning C, Doeblin P, Abdelmeguid M, Talat M, Gebker R, E-Naggar W, Pieske B, and Kelle S

Subjects
Aged, Contrast Media, Female, Gadolinium, Humans, Longitudinal Studies, Magnetic Resonance Imaging, Cine, Magnetic Resonance Spectroscopy, Male, Predictive Value of Tests, Prognosis, Risk Assessment, Stroke Volume, Ventricular Function, Left, Atrial Fibrillation complications, Atrial Fibrillation diagnosis, Vasodilator Agents
Abstract

Aims: Although the prevalence of coronary artery disease (CAD) is high among patients with atrial fibrillation (AF), studies on stress perfusion cardiac magnetic resonance (CMR) imaging frequently exclude patients with AF, and its prognostic and diagnostic value in high-risk patients with suspected or known CAD remains unclear., Methods and Results: In this longitudinal cohort study, we included 164 consecutive patients with AF during vasodilator perfusion CMR. Diagnostic value was evaluated regarding invasive coronary angiography in a subset of patients. We targeted a follow-up of >5 years and used CMR results as stratification, and the primary outcome was major adverse cardiac events [MACE, cardiovascular (CV) death and myocardial infarction (MI)]. Secondary outcomes included late coronary revascularization or stroke and the components of the primary outcome. Of the whole cohort (73.8% male, mean age 72.2 years ± 7.8 SD), 99.4% were successfully scanned (163/164 patients). Median CHA2DS2-VASc score was 4 [interquartile range (IQR) 3-5], and median 10-year risk for CV events based on SMART risk score was high (24%, IQR 16-32%). Thirty-two patients (19.6%) presented with ischaemia and 52 patients (31.9%) with late gadolinium enhancement (LGE). A combination of LGE and inducible ischaemia was present in 20 patients (12.3%). Diagnostic accuracy was 86.2% [confidence interval (CI) 68.3-96.1%]. The median follow-up was 6.6 years (IQR 3.6-7.8). Ischaemia in vasodilator perfusion CMR was significantly associated with the occurrence of MACE [P < 0.01; hazard ratio (HR) 2.65, CI 1.39-5.08], as well as LGE (P = 0.03; 1.74, CI 1.07-3.64) and the combination of both (P < 0.01; HR 2.67, CI 1.59-5.62). After adjustment by age, left ventricular ejection fraction, and the presence of diabetes, ischaemia in vasodilator perfusion CMR remained significantly associated with the occurrence of MACE (2.10, CI 1.08-4.10; P = 0.03). In secondary endpoint analysis, there was a significant association of ischaemia in CMR with CV death (P < 0.05; HR 1.93, CI 0.95-3.9) and MI (P < 0.01; HR 13, CI 1.35-125.4), while no significant association was found regarding the occurrence of revascularization (P = 0.45; HR 1.43, CI 0.57-3.58) or stroke (P = 0.99; HR 0.99, CI 0.21-2.59)., Conclusions: Vasodilator stress perfusion CMR demonstrated an excellent diagnostic and significant prognostic value at long-term follow-up in high-risk patients with persistent AF and suspected or known CAD., (© 2021 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on behalf of European Society of Cardiology.)

Published
2022
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44. Cardiac Magnetic Resonance Reveals Incipient Cardiomyopathy Traits in Adult Patients With Phenylketonuria.

Author

Tanacli R, Hassel JH, Gebker R, Berger A, Gräfe M, Schneeweis C, Doeblin P, Fleck E, Stehning C, Tacke F, Pieske B, Spranger J, Plöckinger U, Ziagaki A, and Kelle S

Subjects
Adult, Humans, Magnetic Resonance Spectroscopy, Phenotype, Phenylalanine blood, Tyrosine blood, Young Adult, Cardiomyopathies diagnostic imaging, Phenylketonurias complications
Abstract

Background Phenylketonuria is the most common inborn error of amino acid metabolism, where oxidative stress and collateral metabolic abnormalities are likely to cause cardiac structural and functional modifications. We aim herein to characterize the cardiac phenotype of adult subjects with phenylketonuria using advanced cardiac imaging. Methods and Results Thirty-nine adult patients with phenylketonuria (age, 30.5±8.7 years; 10-year mean phenylalanine concentration, 924±330 µmol/L) and 39 age- and sex-matched healthy controls were investigated. Participants underwent a comprehensive cardiac magnetic resonance and echocardiography examination. Ten-year mean plasma levels of phenylalanine and tyrosine were used to quantify disease activity and adherence to treatment. Patients with phenylketonuria had thinner left ventricular walls (septal end-diastolic thickness, 7.0±17 versus 8.8±1.7 mm [ P <0.001]; lateral thickness, 6.1±1.4 versus 6.8±1.2 mm [ P =0.004]), more dilated left ventricular cavity (end-diastolic volume, 87±14 versus 80±14 mL/m 2 [ P =0.0178]; end-systolic volume, 36±9 versus 29±8 mL/m 2 [ P <0.001]), lower ejection fraction (59±6% versus 64±6% [ P <0.001]), reduced systolic deformation (global circumferential strain, -29.9±4.2 % versus -32.2±5.0 % [ P =0.027]), and lower left ventricular mass (38.2±7.9 versus 47.8±11.0 g/m 2 [ P <0.001]). T1 native values were decreased (936±53 versus 996±26 ms [ P <0.001]), with particular low values in patients with phenylalanine >1200 µmol/L (909±48 ms). Both mean phenylalanine ( P =0.013) and tyrosine ( P =0.035) levels were independently correlated with T1; and in a multiple regression model, higher phenylalanine levels and higher left ventricular mass associate with lower T1. Conclusions Cardiac phenotype of adult patients with phenylketonuria reveals some traits of an early-stage cardiomyopathy. Regular cardiology follow-up, tighter therapeutic control, and prophylaxis of cardiovascular risk factors, in particular dyslipidemia, are recommended.

Published
2021
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45. Right ventricular thrombus, a challenge in imaging diagnostics: a case series.

Author

Barbagallo M, Naef D, Köpfli P, Hufschmid U, Niemann T, Gebker R, Beer JH, and Hireche-Chiakoui H

Abstract

Background: Presence of right ventricular thrombus (RVT) is a rare but life-threatening condition, thus immediate diagnosis and therapy are mandatory. Unfortunately, detection and distinction from intraventricular tumour masses or vegetations represent a complex task. Furthermore, consecutive therapy is principally led by clinical presentation without considering morphological features of the thrombus. Current literature suggests a multimodal non-invasive imaging approach. In this article, we discuss the role of cardiac magnetic resonance imaging (CMR) for the detection of RVT in patients with pulmonary embolism (PE). We consider the relatively expensive and not broadly available imaging procedure and weigh it up to its assumed high sensitivity, specificity, and importance for differential diagnosis and therapeutic decision-making., Case Summary: In this case series, we report three cases of RVT with concomitant PE, whereof two were missed during routine cardiac workup by transthoracic echocardiography and computer tomography. Cardiac magnetic resonance imaging led to detection and further characterization of the thrombi in both cases., Conclusions: Cardiac magnetic resonance imaging reliably detects and characterizes RVT, even under unfavourable conditions for echocardiography such as arrhythmia, adiposity, or in posterior position of RVT. Obtained information could facilitate the choice of therapeutic approach (anticoagulation vs. systemic lysis vs. surgical thrombectomy). Future risk stratification scores will promote cost-effective use of CMR., (© The Author(s) 2021. Published by Oxford University Press on behalf of the European Society of Cardiology.)

Published
2021
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46. Case Report: Early Transplant Rejection of a Methanol-Intoxicated Donor Heart in a Young Female Patient. A Diagnostic Approach With CMR, Cardiac Biopsy, and Genetic Risk Assessment.

Author

Stoiber L, Schoenrath F, Knosalla C, Milting H, Klingel K, Tschöpe C, Tanacli R, Gebker R, Berger A, Pieske B, and Kelle S

Subjects
Alcoholic Intoxication diagnosis, Biopsy, Cardiomyopathy, Dilated diagnosis, Cardiomyopathy, Dilated physiopathology, Diagnosis, Differential, Donor Selection, Female, Genetic Predisposition to Disease, Graft Rejection etiology, Graft Rejection genetics, Graft Rejection therapy, Heart Failure diagnosis, Heart Failure physiopathology, Humans, Middle Aged, Predictive Value of Tests, Risk Assessment, Risk Factors, Time Factors, Treatment Outcome, Young Adult, Alcoholic Intoxication complications, Cardiomyopathy, Dilated surgery, Graft Rejection diagnosis, Heart Failure surgery, Heart Transplantation adverse effects, Magnetic Resonance Imaging, Methanol poisoning, Molecular Diagnostic Techniques, Tissue Donors
Abstract

This case report describes the contributions of multimodality imaging, cardiac biopsy, and genetic sequencing to the diagnosis and management of heart transplant rejection in a 23-year old patient with dilated cardiomyopathy., Competing Interests: FS reports non-financial support from Medtronic, grants from Novartis, grants from Abbott, personal fees from Cardiorentis, outside the submitted work. CK and SK received support from the DZHK (German Center for Cardiovascular Research), Partner Site Berlin. SK received support from Philips Healthcare. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2021 Stoiber, Schoenrath, Knosalla, Milting, Klingel, Tschöpe, Tanacli, Gebker, Berger, Pieske and Kelle.)

Published
2021
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47. Review of safety reports of cardiac MR-imaging in patients with recently implanted coronary artery stents at various field strengths.

Author

Schenk CD, Gebker R, Berger A, Pieske B, Stehning C, and Kelle S

Subjects
Coronary Artery Disease, Humans, Treatment Outcome, Coronary Vessels diagnostic imaging, Magnetic Resonance Imaging, Stents adverse effects
Abstract

Background : Aim of this study was to review current literature and data regarding the effects of MRI-examination post stent implantation on re-occlusion rates. Methods : We focused on representative studies in the database MEDLINE. Inclusion criteria were: clinical studies with the main focus on the safety of coronary artery stents after MRI-examination in the time interval of 8 weeks post stent implantation. During a follow up period the incidence of cardiac events was recorded. In addition, the time interval between stent implantation and MRI-examination should be defined. Results : Our search resulted in a total of relevant 17 studies. There were in-vivo as well as in-vitro studies and in addition three further publications f.e. guidelines. Concerning the patients, we differentiated between MRI performed shortly after acute cardiac event and in stable CAD. MRI-examinations were performed at different field strengths and reported different stent types. Considered were the incidences of cardiac events. Conclusion : Independent of MRI field strength (1.5 Tesla or 3.0 Tesla) or used stent type (BMS or DES), there was no increased rate for cardiac events in patients, who underwent MRI < 8 weeks after stent placement. MRI < 8 weeks after stent placement seems to be safe.

Published
2021
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48. Late onset apical hypertrophic cardiomyopathy: a case report.

Author

Doeblin P, Gebker R, Pieske B, and Kelle S

Abstract

Background: Apical hypertrophic cardiomyopathy provides diagnostic challenges through varying presentation, impaired visualization on echocardiography and dissent on diagnostic criteria. While hypertrophic cardiomyopathy in general requires an absolute wall thickness ≥15 mm, a threshold for relative apical hypertrophy (ratio 1.5) has been proposed., Case Summary: We report the case of a 57-year-old man with newly arisen chest pain and slight T-wave inversions. Serial cardiac magnetic resonance imaging over 9 years documented the gradual evolvement of late-onset apical hypertrophy with apical fibrosis and strain abnormalities. Symptoms, electrocardiographic changes, and relative apical hypertrophy preceded the traditional imaging criteria of hypertrophic cardiomyopathy., Discussion: Relative apical hypertrophy can be an early manifestation of apical hypertrophic cardiomyopathy. Persistent cardiac signs and symptoms warrant a follow-up, as apical hypertrophic cardiomyopathy can evolve over time. Cardiac magnetic resonance imaging readily visualizes apical hypertrophic cardiomyopathy and associated changes in tissue composition and function., (© The Author(s) 2020. Published by Oxford University Press on behalf of the European Society of Cardiology.)

Published
2020
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49. Cardiac Myxomas Show Elevated Native T1, T2 Relaxation Time and ECV on Parametric CMR.

Author

Nasser SB, Doeblin P, Doltra A, Schnackenburg B, Wassilew K, Berger A, Gebker R, Bigvava T, Hennig F, Pieske B, and Kelle S

Abstract

Introduction: While cardiac tumors are rare, their identification and differentiation has wide clinical implications. Recent cardiac magnetic resonance (CMR) parametric mapping techniques allow for quantitative tissue characterization. Our aim was to examine the range of values encountered in cardiac myxomas in correlation to histological measurements. Methods and Results: Nine patients with histologically proven cardiac myxomas were included. CMR (1.5 Tesla, Philips) including parametric mapping was performed in all patients pre-operatively. All data are reported as mean ± standard deviation. Compared to myocardium, cardiac myxomas demonstrated higher native T1 relaxation times (1,554 ± 192 ms vs. 1,017 ± 58 ms, p < 0.001), ECV (46.9 ± 13.0% vs. 27.1 ± 2.6%, p = 0.001), and T2 relaxation times (209 ± 120 ms vs. 52 ± 3 ms, p = 0.008). Areas with LGE showed higher ECV than areas without (54.3 ± 17.8% vs. 32.7 ± 18.6%, p = 0.042), with differences in native T1 relaxation times (1,644 ± 217 ms vs. 1,482 ± 351 ms, p = 0.291) and T2 relaxation times (356 ± 236 ms vs. 129 ± 68 ms, p = 0.155) not reaching statistical significance. Conclusions: Parametric CMR showed elevated native T1 and T2 relaxation times and ECV values in cardiac myxomas compared to normal myocardium, reflecting an increased interstitial space and fluid content. This might help in the differentiation of cardiac myxomas from other tumor entities., (Copyright © 2020 Nasser, Doeblin, Doltra, Schnackenburg, Wassilew, Berger, Gebker, Bigvava, Hennig, Pieske and Kelle.)

Published
2020
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50. Long-term left atrial remodeling after ablation of persistent atrial fibrillation: 7-year follow-up by cardiovascular magnetic resonance imaging.

Author

Kriatselis C, Unruh T, Kaufmann J, Gerds-Li JH, Kelle S, Gebker R, Jahnke C, Paetsch I, and Pieske B

Subjects
Follow-Up Studies, Humans, Magnetic Resonance Imaging, Treatment Outcome, Atrial Fibrillation diagnostic imaging, Atrial Fibrillation surgery, Atrial Remodeling, Catheter Ablation
Abstract

Purpose: Restoration of sinus rhythm in patients with persistent atrial fibrillation (ps. AF) induces reverse atrial remodeling and improvement of left ventricular function. We evaluated the effect of ablative treatment on cardiac remodeling after a long follow-up period of 7 years by cardiovascular magnetic resonance (CMR)., Methods: Patients with symptomatic ps. AF underwent CMR within 7 days prior to the ablation procedure. Left atrial and ventricular volumes were measured. All patients underwent circumferential pulmonary vein isolation. At the end of follow-up (FU), a CMR and 7-day ECG registration were performed., Results: Forty-two patients (67 ± 9 years) were included. After a FU of 86 ± 13 months, 23 patients had a successful outcome. In these patients, LVEF improved from 56 ± 5 to 62 ± 4% (p = 0.02), but left atrial volume and ejection fraction (LAV, LAEF) remained unchanged (105 ± 25 to 98 ± 34, p = 0.44; 34 ± 10 to 36 ± 11, p = 0.6, respectively). In 14 patients with a BMI < 30 and no left ventricular hypertrophy (LVH), LAV decreased (104 ± 30 to 82 ± 26 ml, p = 0.01) and LAEF improved (33 ± 12 to 40 ± 11%, p = 0.03). In 9 patients with successful outcome and either BMI ≥ 30 or LVH, LAV increased (110 ± 26 to 125 ± 30 ml, p = 0.03) and LAEF deteriorated (35 ± 11 to 31 ± 10%, p = 0.04)., Conclusions: Successful ablative treatment of atrial fibrillation is associated with reverse left atrial remodeling and improvement of left atrial and ventricular function. In patients with a BMI ≥ 30 or left ventricular hypertrophy, further left atrial enlargement occurs despite successful outcome.

Published
2020
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