44 results on '"Gegg, Matthew E."'
Search Results
2. α-Synuclein expression in response to bacterial ligands and metabolites in gut enteroendocrine cells – an in vitro proof of concept study
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Hurley, Michael J, primary, Menozzi, Elisa, additional, Koletsi, Sofia, additional, Bates, Rachel, additional, Gegg, Matthew E, additional, Chau, Kai-Yin, additional, Blottière, Hervé M, additional, Macnaughtan, Jane, additional, and Schapira, Anthony H V, additional
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- 2023
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3. Interaction Between Mitochondria and Autophagy
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Gegg, Matthew E., Kostrzewa, Richard, Series editor, Archer, Trevor, Series editor, and Fuentes, José M., editor
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- 2015
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4. Unexpected phenotypic and molecular changes of combined glucocerebrosidase and acid sphingomyelinase deficiency
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Keatinge, Marcus, primary, Gegg, Matthew E., additional, Watson, Lisa, additional, Mortiboys, Heather, additional, Li, Nan, additional, Dunning, Mark, additional, Ailani, Deepak, additional, Bui, Hai, additional, van Rens, Astrid, additional, Lefeber, Dirk J., additional, Schapira, Anthony H.V., additional, MacDonald, Ryan B., additional, and Bandmann, Oliver, additional
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- 2023
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5. Lysosomal-endolysomal dysfunction and neurodegenerative diseases
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Gegg, Matthew E., primary and Schapira, Anthony H.V., additional
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- 2022
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6. The GBA variant E326K is associated with alpha-synuclein aggregation and lipid droplet accumulation in human cell lines
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Smith, Laura J, primary, Bolsinger, Magdalena M, additional, Chau, Kai-Yin, additional, Gegg, Matthew E, additional, and Schapira, Anthony H V, additional
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- 2022
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7. DJ-1 is a redox sensitive adapter protein for high molecular weight complexes involved in regulation of catecholamine homeostasis
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Piston, Dominik, Alvarez-Erviti, Lydia, Bansal, Vikas, Gargano, Daniela, Yao, Zhi, Szabadkai, Gyorgy, Odell, Mark, Puno, Rhyan M, Björkblom, Benny, Maple-Grødem, Jodi, Breuer, Peter, Kaut, Oliver, Larsen, Jan Petter, Bonn, Stefan, Møller, Simon Geir, Wüllner, Ullrich, Schapira, Anthony H V, and Gegg, Matthew E
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- 2017
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8. The GBA variant E326K is associated with alpha-synuclein aggregation and lipid droplet accumulation in human cell lines
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Smith, Laura. J., primary, Bolsinger, Magdalena. M., additional, Chau, Kai-Yin., additional, Gegg, Matthew. E., additional, and Schapira, Anthony. H. V., additional
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- 2022
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9. Glucocerebrosidase-associated Parkinson disease: Pathogenic mechanisms and potential drug treatments
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Gegg, Matthew E., primary, Menozzi, Elisa, additional, and Schapira, Anthony H.V., additional
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- 2022
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10. Mitochondria and Quality Control Defects in a Mouse Model of Gaucher Disease—Links to Parkinson’s Disease
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Osellame, Laura D., Rahim, Ahad A., Hargreaves, Iain P., Gegg, Matthew E., Richard-Londt, Angela, Brandner, Sebastian, Waddington, Simon N., Schapira, Anthony H.V., and Duchen, Michael R.
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- 2013
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11. Glucocerebrosidase in the pathogenesis and treatment of Parkinson disease
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Schapira, Anthony H. V. and Gegg, Matthew E.
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- 2013
12. The GBA variant E326K is associated with alpha-synuclein aggregation and lipid droplet accumulation in human cell lines.
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Smith, Laura J, Bolsinger, Magdalena M, Chau, Kai-Yin, Gegg, Matthew E, and Schapira, Anthony H V
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- 2023
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13. Mitochondrial and lysosomal biogenesis are activated following PINK1/parkin-mediated mitophagy
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Ivankovic, Davor, Chau, Kai-Yin, Schapira, Anthony H. V., and Gegg, Matthew E.
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- 2016
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14. No evidence for substrate accumulation in Parkinson brains with GBA mutations
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Gegg, Matthew E., Sweet, Lindsay, Wang, Bing H., Shihabuddin, Lamya S., Sardi, Sergio Pablo, and Schapira, Anthony H.V.
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- 2015
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15. Contributors
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Abeliovich, Hagai, primary, Bernabei, Roberto, additional, Boga, Jose A., additional, Calvani, Riccardo, additional, Chen, Min, additional, Chua, Doreen S.K., additional, Coto-Montes, Ana, additional, Devenish, Rodney J., additional, Galindo, María F., additional, Gegg, Matthew E., additional, Hattori, Nobutaka, additional, Hayat, M.A., additional, Imai, Yuzuru, additional, Inoshita, Tsuyoshi, additional, Jordán, Joaquín, additional, Kanki, Tomotake, additional, Klionsky, Daniel J., additional, Kurihara, Yusuke, additional, Leeuwenburgh, Christiaan, additional, Leung, Wingnang, additional, Lim, Kah-Leong, additional, Lokireddy, Sudarsanareddy, additional, Lorenzi, Maria, additional, Marzetti, Emanuele, additional, Mijaljica, Dalibor, additional, Palau, Xavier Gallart, additional, Prescott, Mark, additional, Reiter, Russel J., additional, Simpson-Lavy, Kobi J., additional, Solesio, Maria E., additional, Sun, Huanhuan, additional, Tieu, Kim, additional, Tolkovsky, Aviva M., additional, Wang, Jin, additional, Wang, Ke, additional, Wang, Lei, additional, Xu, Chuanshan, additional, and Yao, Tso-Pang, additional
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- 2014
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16. Ubiquitination of Mitofusins in PINK1/Parkin-Mediated Mitophagy
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Gegg, Matthew E., primary
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- 2014
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17. Glucocerebrosidase deficiency in substantia nigra of parkinson disease brains
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Gegg, Matthew E., Burke, Derek, Heales, Simon J. R., Cooper, Mark J., Hardy, John, Wood, Nicholas W., and Schapira, Anthony H. V.
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- 2012
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18. Acid Sphingomyelinase Deficiency Normalizes Neuronal Function in GCase Deficiency - Unexpected Biological Rescue Effect of Combined Genetic Risk Factors for Parkinson’s Disease
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Keatinge, Marcus, primary, Gegg, Matthew E, additional, Watson, Lisa, additional, Mortiboys, Heather, additional, Bui, Hai, additional, Lefeber, Dirk, additional, Rens, Astrid Van, additional, MacDonald, Ryan, additional, Schapira, Anthony, additional, and Bandmann, Oliver, additional
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- 2020
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19. Glucocerebrosidase deficiency promotes release of α-synuclein fibrils from cultured neurons
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Gegg, Matthew E, primary, Verona, Guglielmo, primary, and Schapira, Anthony H V, primary
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- 2020
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20. Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/parkin-dependent manner upon induction of mitophagy
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Gegg, Matthew E., Cooper, J. Mark, Chau, Kai-Yin, Rojo, Manuel, Schapira, Anthony H.V., and Taanman, Jan-Willem
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- 2010
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21. Loss of acid sphingomyelinase ameliorates disease progression in a vertebrate model of Glucocerebrosidase deficiency
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Keatinge, Marcus, Gegg, Matthew E., Watson, Lisa, Mortiboys, Heather, Bui, Hai, van Rens, Astrid, Lefeber, Dirk J., MacDonald, Ryan B., Schapira, Anthony H.V., and Bandmann, Oliver
- Abstract
Biallelic glucocerebrosidase (GBA) mutations cause the lysosomal storage disorder Gaucher disease (GD), while heterozygous GBA variants are the strongest and most common genetic risk factor for Parkinson disease (PD). An excessive burden of other lysosomal storage disorder gene variants, in particular for SMPD1 (encoding for acid sphingomyelinase (ASM)) has also been reported in PD. However, it is unclear whether GBA and SMPD1 interact genetically. Zebrafish are an ideal vertebrate system to test for such interactions. We previously characterised a gba1 −/− mutant zebrafish line which displayed key hallmarks of human GD. In this work, we describe the biological interaction of combined glucocerebrosidase (GCase) and ASM deficiency in gba1 −/− ; smpd1 −/− double mutant zebrafish. We observed a marked increase of glucosylceramide, ceramide and other key sphingolipids or their metabolites in gba1 −/− ; smpd1 −/− compared to gba1 −/− or smpd1 −/− zebrafish. Unexpectedly, we observed a marked ameliorating effect of ASM inactivation on behaviour and disease duration in gba1 −/− , resulting in a rescue of the characteristic motor phenotype and improved survival in gba1 −/− ; smpd1 −/− . We identified complete rescue of mitochondrial respiratory chain function with normalisation of lipid peroxidation as the underlying mechanism for the observed rescue effect in gba1 −/− ; smpd1 −/− . Combined ASM knockdown and GCase inhibition in human neuroblastoma SH-SY5Y cells unexpectedly lead to a decrease in monomeric α-synuclein, a key pathogenic protein in PD, which was independent of changes in macroautophagy flux. Our work highlights the importance of investigating the downstream functional consequences of gene-gene interactions in complex interacting pathways to determine any composite risk. Significance statement The additive effect of genetic risk variants on disease incidence is a popular but frequently unproven hypothesis. Variants in the lysosomal disease genes glucocerebrosidase1 ( GBA1 ) and sphingomyelinase ( SMPD1 ) are risk factors for Parkinson’s disease (PD). Zebrafish are ideally suited to study gene-gene interaction. We investigated a genetic interaction between gba1 −/− and smpd1 −/− in gba1 −/− ; smpd1 −/− double-mutant zebrafish and observed an unexpected ameliorating effect of sphingomyelinase deficiency on the gba1 −/− related phenotype with prolonged survival and normalisation of motor behaviour due to rescue of mitochondrial function. Complementing experiments in SH-SY5Y neuroblastoma cells revealed an unexpected lowering of α-synuclein in the presence of combined glucocerebrosidase and sphingomyelinase inhibition. Our study highlights the importance of functional validation for any putative gene-gene interactions.
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- 2019
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22. Oxidative phosphorylation: Structure, function, and intermediary metabolism
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Heales, Simon J.R., primary, Gegg, Matthew E., additional, and Clark, John B., additional
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- 2002
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23. The importance of being connected: membrane contact sites and Parkinson's disease.
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Gegg, Matthew E.
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- 2023
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24. Preservation of extracellular glutathione by an astrocyte derived factor with properties comparable to extracellular superoxide dismutase
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Stewart, Victoria C., Stone, Rebecca, Gegg, Matthew E., Sharpe, Martyn A., Hurst, Roger D., Clark, John B., and Heales, Simon J. R.
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- 2002
25. Autophagic lysosome reformation dysfunction in glucocerebrosidase deficient cells: relevance to Parkinson disease
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Magalhaes, Joana, Gegg, Matthew E., Migdalska-Richards, Anna, Doherty, Mary K., Whitfield, Phillip D., and Schapira, Anthony H.V.
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Neurons ,Gaucher Disease ,Brain ,rab7 GTP-Binding Proteins ,Parkinson Disease ,Articles ,Fibroblasts ,Mice ,rab GTP-Binding Proteins ,Mutation ,Autophagy ,alpha-Synuclein ,Animals ,Glucosylceramidase ,Humans ,Lysosomes - Abstract
Glucocerebrosidase (GBA1) gene mutations increase the risk of Parkinson disease (PD). While the cellular mechanisms associating GBA1 mutations and PD are unknown, loss of the glucocerebrosidase enzyme (GCase) activity, inhibition of autophagy and increased α-synuclein levels have been implicated. Here we show that autophagy lysosomal reformation (ALR) is compromised in cells lacking functional GCase. ALR is a cellular process controlled by mTOR which regenerates functional lysosomes from autolysosomes formed during macroautophagy. A decrease in phopho-S6K levels, a marker of mTOR activity, was observed in models of GCase deficiency, including primary mouse neurons and the PD patient derived fibroblasts with GBA1 mutations, suggesting that ALR is compromised. Importantly Rab7, a GTPase crucial for endosome-lysosome trafficking and ALR, accumulated in GCase deficient cells, supporting the notion that lysosomal recycling is impaired. Recombinant GCase treatment reversed ALR inhibition and lysosomal dysfunction. Moreover, ALR dysfunction was accompanied by impairment of macroautophagy and chaperone-mediated autophagy, increased levels of total and phosphorylated (S129) monomeric α-synuclein, evidence of amyloid oligomers and increased α-synuclein release. Concurrently, we found increased cholesterol and altered glucosylceramide homeostasis which could compromise ALR. We propose that GCase deficiency in PD inhibits lysosomal recycling. Consequently neurons are unable to maintain the pool of mature and functional lysosomes required for the autophagic clearance of α-synuclein, leading to the accumulation and spread of pathogenic α-synuclein species in the brain. Since GCase deficiency and lysosomal dysfunction occur with ageing and sporadic PD pathology, the decrease in lysosomal reformation may be a common feature in PD.
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- 2016
26. Corrigendum to 'DJ-1 is a redox sensitive adapter protein for high molecular weight complexes involved in regulation of catecholamine homeostasis.'
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Piston, Dominik, Alvarez-Erviti, Lydia, Breuer, Peter, Kaut, Oliver, Larsen, Jan Petter, Bonn, Stefan, Møller, Simon Geir, Wüllner, Ullrich, Schapira, Anthony H V, Gegg, Matthew E, Bansal, Vikas, Gargano, Daniela, Yao, Zhi, Szabadkai, Gyorgy, Odell, Mark, Puno, M Rhyan, Björkblom, Benny, and Maple-Grødem, Jodi
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ddc:570 - Published
- 2018
27. Unexpected opposing biological effect of genetic risk factors for Parkinson’s disease
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Keatinge, Marcus, primary, Gegg, Matthew E., additional, Watson, Lisa, additional, Mortiboys, Heather, additional, Li, Nan, additional, Dunning, Mark, additional, Ailani, Deepak, additional, Bui, Hai, additional, van Rens, Astrid, additional, Lefeber, Dirk J., additional, MacDonald, Ryan B., additional, Schapira, Anthony H.V., additional, and Bandmann, Oliver, additional
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- 2019
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28. Determination of Glutamate-Cysteine Ligase (γ-Glutamylcysteine Synthetase) Activity by High-Performance Liquid Chromatography and Electrochemical Detection
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Gegg, Matthew E., Clark, John B., and Heales, Simon J.R.
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- 2002
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29. The role of glucocerebrosidase in Parkinson disease pathogenesis
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Gegg, Matthew E., primary and Schapira, Anthony H. V., additional
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- 2018
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30. Parkinson disease-linked GBA mutation effects reversed by molecular chaperones in human cell and fly models
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Sanchez-Martinez, Alvaro, primary, Beavan, Michelle, additional, Gegg, Matthew E., additional, Chau, Kai-Yin, additional, Whitworth, Alexander J., additional, and Schapira, Anthony H. V., additional
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- 2016
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31. Mitochondrial dysfunction associated with glucocerebrosidase deficiency
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Gegg, Matthew E., primary and Schapira, Anthony H.V., additional
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- 2016
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32. Endoplasmic reticulum and lysosomal Ca2+ stores are remodelled in GBA1-linked Parkinson disease patient fibroblasts
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Kilpatrick, Bethan S., primary, Magalhaes, Joana, additional, Beavan, Michelle S., additional, McNeill, Alisdair, additional, Gegg, Matthew E., additional, Cleeter, Michael W.J., additional, Bloor-Young, Duncan, additional, Churchill, Grant C., additional, Duchen, Michael R., additional, Schapira, Anthony H., additional, and Patel, Sandip, additional
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- 2016
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33. Mitochondria: Key Organelle in Parkinson’s Disease
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Gómez-Sánchez, Rubén, primary, Bravo-San Pedro, José M., additional, Gegg, Matthew E., additional, González-Polo, Rosa A., additional, and Fuentes, José M., additional
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- 2016
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34. Mitochondrial and lysosomal biogenesis are activated following PINK 1/parkin‐mediated mitophagy
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Ivankovic, Davor, primary, Chau, Kai‐Yin, additional, Schapira, Anthony H. V., additional, and Gegg, Matthew E., additional
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- 2015
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35. Mitochondrial impairment increases FL-PINK1 levels by calcium-dependent gene expression
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Gómez-Sánchez, Rubén, primary, Gegg, Matthew E., additional, Bravo-San Pedro, José M., additional, Niso-Santano, Mireia, additional, Alvarez-Erviti, Lydia, additional, Pizarro-Estrella, Elisa, additional, Gutiérrez-Martín, Yolanda, additional, Alvarez-Barrientos, Alberto, additional, Fuentes, José M., additional, González-Polo, Rosa Ana, additional, and Schapira, Anthony H.V., additional
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- 2014
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36. Accumulation of damaged mitochondria in neuropathic Gaucher disease, the most prevalent risk factor for Parkinson's disease, is due to defective cellular degradation machinery
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Osellame, Laura D., primary, Rahim, Ahad, additional, Gegg, Matthew E., additional, Waddington, Simon, additional, Schapira, Anthony H.V., additional, and Duchen, Michael R., additional
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- 2012
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37. Guidelines for the use and interpretation of assays for monitoring autophagy
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Klionsky, Daniel J., primary, Abdalla, Fabio C., additional, Abeliovich, Hagai, additional, Abraham, Robert T., additional, Acevedo-Arozena, Abraham, additional, Adeli, Khosrow, additional, Agholme, Lotta, additional, Agnello, Maria, additional, Agostinis, Patrizia, additional, Aguirre-Ghiso, Julio A., additional, Ahn, Hyung Jun, additional, Ait-Mohamed, Ouardia, additional, Ait-Si-Ali, Slimane, additional, Akematsu, Takahiko, additional, Akira, Shizuo, additional, Al-Younes, Hesham M., additional, Al-Zeer, Munir A., additional, Albert, Matthew L., additional, Albin, Roger L., additional, Alegre-Abarrategui, Javier, additional, Aleo, Maria Francesca, additional, Alirezaei, Mehrdad, additional, Almasan, Alexandru, additional, Almonte-Becerril, Maylin, additional, Amano, Atsuo, additional, Amaravadi, Ravi K., additional, Amarnath, Shoba, additional, Amer, Amal O., additional, Andrieu-Abadie, Nathalie, additional, Anantharam, Vellareddy, additional, Ann, David K., additional, Anoopkumar-Dukie, Shailendra, additional, Aoki, Hiroshi, additional, Apostolova, Nadezda, additional, Arancia, Giuseppe, additional, Aris, John P., additional, Asanuma, Katsuhiko, additional, Asare, Nana Y.O., additional, Ashida, Hisashi, additional, Askanas, Valerie, additional, Askew, David S., additional, Auberger, Patrick, additional, Baba, Misuzu, additional, Backues, Steven K., additional, Baehrecke, Eric H., additional, Bahr, Ben A., additional, Bai, Xue-Yuan, additional, Bailly, Yannick, additional, Baiocchi, Robert, additional, Baldini, Giulia, additional, Balduini, Walter, additional, Ballabio, Andrea, additional, Bamber, Bruce A., additional, Bampton, Edward T.W., additional, Juhász, Gábor, additional, Bartholomew, Clinton R., additional, Bassham, Diane C., additional, Bast, Robert C., additional, Batoko, Henri, additional, Bay, Boon-Huat, additional, Beau, Isabelle, additional, Béchet, Daniel M., additional, Begley, Thomas J., additional, Behl, Christian, additional, Behrends, Christian, additional, Bekri, Soumeya, additional, Bellaire, Bryan, additional, Bendall, Linda J., additional, Benetti, Luca, additional, Berliocchi, Laura, additional, Bernardi, Henri, additional, Bernassola, Francesca, additional, Besteiro, Sébastien, additional, Bhatia-Kissova, Ingrid, additional, Bi, Xiaoning, additional, Biard-Piechaczyk, Martine, additional, Blum, Janice S., additional, Boise, Lawrence H., additional, Bonaldo, Paolo, additional, Boone, David L., additional, Bornhauser, Beat C., additional, Bortoluci, Karina R., additional, Bossis, Ioannis, additional, Bost, Frédéric, additional, Bourquin, Jean-Pierre, additional, Boya, Patricia, additional, Boyer-Guittaut, Michaël, additional, Bozhkov, Peter V., additional, Brady, Nathan R, additional, Brancolini, Claudio, additional, Brech, Andreas, additional, Brenman, Jay E., additional, Brennand, Ana, additional, Bresnick, Emery H., additional, Brest, Patrick, additional, Bridges, Dave, additional, Bristol, Molly L., additional, Brookes, Paul S., additional, Brown, Eric J., additional, Brumell, John H., additional, Brunetti-Pierri, Nicola, additional, Brunk, Ulf T., additional, Bulman, Dennis E., additional, Bultman, Scott J., additional, Bultynck, Geert, additional, Burbulla, Lena F., additional, Bursch, Wilfried, additional, Butchar, Jonathan P., additional, Buzgariu, Wanda, additional, Bydlowski, Sergio P., additional, Cadwell, Ken, additional, Cahová, Monika, additional, Cai, Dongsheng, additional, Cai, Jiyang, additional, Cai, Qian, additional, Calabretta, Bruno, additional, Calvo-Garrido, Javier, additional, Camougrand, Nadine, additional, Campanella, Michelangelo, additional, Campos-Salinas, Jenny, additional, Candi, Eleonora, additional, Cao, Lizhi, additional, Caplan, Allan B., additional, Carding, Simon R., additional, Cardoso, Sandra M., additional, Carew, Jennifer S., additional, Carlin, Cathleen R., additional, Carmignac, Virginie, additional, Carneiro, Leticia A.M., additional, Carra, Serena, additional, Caruso, Rosario A., additional, Casari, Giorgio, additional, Casas, Caty, additional, Castino, Roberta, additional, Cebollero, Eduardo, additional, Cecconi, Francesco, additional, Celli, Jean, additional, Chaachouay, Hassan, additional, Chae, Han-Jung, additional, Chai, Chee-Yin, additional, Chan, David C., additional, Chan, Edmond Y., additional, Chang, Raymond Chuen-Chung, additional, Che, Chi-Ming, additional, Chen, Ching-Chow, additional, Chen, Guang-Chao, additional, Chen, Guo-Qiang, additional, Chen, Min, additional, Chen, Quan, additional, Chen, Steve S.-L., additional, Chen, WenLi, additional, Chen, Xi, additional, Chen, Xiangmei, additional, Chen, Xiequn, additional, Chen, Ye-Guang, additional, Chen, Yingyu, additional, Chen, Yongqiang, additional, Chen, Yu-Jen, additional, Chen, Zhixiang, additional, Cheng, Alan, additional, Cheng, Christopher H.K., additional, Cheng, Yan, additional, Cheong, Heesun, additional, Cheong, Jae-Ho, additional, Cherry, Sara, additional, Chess-Williams, Russ, additional, Cheung, Zelda H., additional, Chevet, Eric, additional, Chiang, Hui-Ling, additional, Chiarelli, Roberto, additional, Chiba, Tomoki, additional, Chin, Lih-Shen, additional, Chiou, Shih-Hwa, additional, Chisari, Francis V., additional, Cho, Chi Hin, additional, Cho, Dong-Hyung, additional, Choi, Augustine M.K., additional, Choi, DooSeok, additional, Choi, Kyeong Sook, additional, Choi, Mary E., additional, Chouaib, Salem, additional, Choubey, Divaker, additional, Choubey, Vinay, additional, Chu, Charleen T., additional, Chuang, Tsung-Hsien, additional, Chueh, Sheau-Huei, additional, Chun, Taehoon, additional, Chwae, Yong-Joon, additional, Chye, Mee-Len, additional, Ciarcia, Roberto, additional, Ciriolo, Maria R., additional, Clague, Michael J., additional, Clark, Robert S.B., additional, Clarke, Peter G.H., additional, Clarke, Robert, additional, Codogno, Patrice, additional, Coller, Hilary A., additional, Colombo, María I., additional, Comincini, Sergio, additional, Condello, Maria, additional, Condorelli, Fabrizio, additional, Cookson, Mark R., additional, Coombs, Graham H., additional, Coppens, Isabelle, additional, Corbalan, Ramon, additional, Cossart, Pascale, additional, Costelli, Paola, additional, Costes, Safia, additional, Coto-Montes, Ana, additional, Couve, Eduardo, additional, Coxon, Fraser P., additional, Cregg, James M., additional, Crespo, José L., additional, Cronjé, Marianne J., additional, Cuervo, Ana Maria, additional, Cullen, Joseph J., additional, Czaja, Mark J., additional, D'Amelio, Marcello, additional, Darfeuille-Michaud, Arlette, additional, Davids, Lester M., additional, Davies, Faith E., additional, De Felici, Massimo, additional, de Groot, John F., additional, de Haan, Cornelis A.M., additional, De Martino, Luisa, additional, De Milito, Angelo, additional, De Tata, Vincenzo, additional, Debnath, Jayanta, additional, Degterev, Alexei, additional, Dehay, Benjamin, additional, Delbridge, Lea M.D., additional, Demarchi, Francesca, additional, Deng, Yi Zhen, additional, Dengjel, Jörn, additional, Dent, Paul, additional, Denton, Donna, additional, Deretic, Vojo, additional, Desai, Shyamal D., additional, Devenish, Rodney J., additional, Di Gioacchino, Mario, additional, Di Paolo, Gilbert, additional, Di Pietro, Chiara, additional, Díaz-Araya, Guillermo, additional, Díaz-Laviada, Inés, additional, Diaz-Meco, Maria T., additional, Diaz-Nido, Javier, additional, Dikic, Ivan, additional, Dinesh-Kumar, Savithramma P., additional, Ding, Wen-Xing, additional, Distelhorst, Clark W., additional, Diwan, Abhinav, additional, Djavaheri-Mergny, Mojgan, additional, Dokudovskaya, Svetlana, additional, Dong, Zheng, additional, Dorsey, Frank C., additional, Dosenko, Victor, additional, Dowling, James J., additional, Doxsey, Stephen, additional, Dreux, Marlène, additional, Drew, Mark E., additional, Duan, Qiuhong, additional, Duchosal, Michel A., additional, Duff, Karen E., additional, Dugail, Isabelle, additional, Durbeej, Madeleine, additional, Duszenko, Michael, additional, Edelstein, Charles L., additional, Edinger, Aimee L., additional, Egea, Gustavo, additional, Eichinger, Ludwig, additional, Eissa, N. Tony, additional, Ekmekcioglu, Suhendan, additional, El-Deiry, Wafik S., additional, Elazar, Zvulun, additional, Elgendy, Mohamed, additional, Ellerby, Lisa M., additional, Eng, Kai Er, additional, Engelbrecht, Anna-Mart, additional, Engelender, Simone, additional, Erenpreisa, Jekaterina, additional, Escalante, Ricardo, additional, Esclatine, Audrey, additional, Eskelinen, Eeva-Liisa, additional, Espert, Lucile, additional, Espina, Virginia, additional, Fan, Huizhou, additional, Fan, Jia, additional, Fan, Qi-Wen, additional, Fan, Zhen, additional, Fang, Shengyun, additional, Fang, Yongqi, additional, Fanto, Manolis, additional, Fanzani, Alessandro, additional, Farkas, Thomas, additional, Farre, Jean-Claude, additional, Faure, Mathias, additional, Fechheimer, Marcus, additional, Feng, Carl G., additional, Feng, Jian, additional, Feng, Qili, additional, Feng, Youji, additional, Fésüs, László, additional, Feuer, Ralph, additional, Figueiredo-Pereira, Maria E., additional, Fimia, Gian Maria, additional, Fingar, Diane C., additional, Finkbeiner, Steven, additional, Finkel, Toren, additional, Finley, Kim D., additional, Fiorito, Filomena, additional, Fisher, Edward A., additional, Fisher, Paul B., additional, Flajolet, Marc, additional, Florez-McClure, Maria L., additional, Florio, Salvatore, additional, Fon, Edward A., additional, Fornai, Francesco, additional, Fortunato, Franco, additional, Fotedar, Rati, additional, Fowler, Daniel H., additional, Fox, Howard S., additional, Franco, Rodrigo, additional, Frankel, Lisa B., additional, Fransen, Marc, additional, Fuentes, José M., additional, Fueyo, Juan, additional, Fujii, Jun, additional, Fujisaki, Kozo, additional, Fujita, Eriko, additional, Fukuda, Mitsunori, additional, Furukawa, Ruth H., additional, Gaestel, Matthias, additional, Gailly, Philippe, additional, Gajewska, Malgorzata, additional, Galliot, Brigitte, additional, Galy, Vincent, additional, Ganesh, Subramaniam, additional, Ganetzky, Barry, additional, Ganley, Ian G., additional, Gao, Fen-Biao, additional, Gao, George F., additional, Gao, Jinming, additional, Garcia, Lorena, additional, Garcia-Manero, Guillermo, additional, Garcia-Marcos, Mikel, additional, Garmyn, Marjan, additional, Gartel, Andrei L., additional, Gatti, Evelina, additional, Gautel, Mathias, additional, Gawriluk, Thomas R., additional, Gegg, Matthew E., additional, Geng, Jiefei, additional, Germain, Marc, additional, Gestwicki, Jason E., additional, Gewirtz, David A., additional, Ghavami, Saeid, additional, Ghosh, Pradipta, additional, Giammarioli, Anna M., additional, Giatromanolaki, Alexandra N., additional, Gibson, Spencer B., additional, Gilkerson, Robert W., additional, Ginger, Michael L., additional, Ginsberg, Henry N., additional, Golab, Jakub, additional, Goligorsky, Michael S., additional, Golstein, Pierre, additional, Gomez-Manzano, Candelaria, additional, Goncu, Ebru, additional, Gongora, Céline, additional, Gonzalez, Claudio D., additional, Gonzalez, Ramon, additional, González-Estévez, Cristina, additional, González-Polo, Rosa Ana, additional, Gonzalez-Rey, Elena, additional, Gorbunov, Nikolai V., additional, Gorski, Sharon, additional, Goruppi, Sandro, additional, Gottlieb, Roberta A., additional, Gozuacik, Devrim, additional, Granato, Giovanna Elvira, additional, Grant, Gary D., additional, Green, Kim N., additional, Gregorc, Ales, additional, Gros, Frédéric, additional, Grose, Charles, additional, Grunt, Thomas W., additional, Gual, Philippe, additional, Guan, Jun-Lin, additional, Guan, Kun-Liang, additional, Guichard, Sylvie M., additional, Gukovskaya, Anna S., additional, Gukovsky, Ilya, additional, Gunst, Jan, additional, Gustafsson, Åsa B., additional, Halayko, Andrew J., additional, Hale, Amber N., additional, Halonen, Sandra K., additional, Hamasaki, Maho, additional, Han, Feng, additional, Han, Ting, additional, Hancock, Michael K., additional, Hansen, Malene, additional, Harada, Hisashi, additional, Harada, Masaru, additional, Hardt, Stefan E., additional, Harper, J. Wade, additional, Harris, Adrian L., additional, Harris, James, additional, Harris, Steven D., additional, Hashimoto, Makoto, additional, Haspel, Jeffrey A., additional, Hayashi, Shin-ichiro, additional, Hazelhurst, Lori A., additional, He, Congcong, additional, He, You-Wen, additional, Hébert, Marie-Josée, additional, Heidenreich, Kim A., additional, Helfrich, Miep H., additional, Helgason, Gudmundur V., additional, Henske, Elizabeth P., additional, Herman, Brian, additional, Herman, Paul K., additional, Hetz, Claudio, additional, Hilfiker, Sabine, additional, Hill, Joseph A., additional, Hocking, Lynne J., additional, Hofman, Paul, additional, Hofmann, Thomas G., additional, Höhfeld, Jörg, additional, Holyoake, Tessa L., additional, Hong, Ming-Huang, additional, Hood, David A., additional, Hotamisligil, Gökhan S., additional, Houwerzijl, Ewout J., additional, Høyer-Hansen, Maria, additional, Hu, Bingren, additional, Hu, Chien-an A., additional, Hu, Hong-Ming, additional, Hua, Ya, additional, Huang, Canhua, additional, Huang, Ju, additional, Huang, Shengbing, additional, Huang, Wei-Pang, additional, Huber, Tobias B., additional, Huh, Won-Ki, additional, Hung, Tai-Ho, additional, Hupp, Ted R., additional, Hur, Gang Min, additional, Hurley, James B., additional, Hussain, Sabah N.A., additional, Hussey, Patrick J., additional, Hwang, Jung Jin, additional, Hwang, Seungmin, additional, Ichihara, Atsuhiro, additional, Ilkhanizadeh, Shirin, additional, Inoki, Ken, additional, Into, Takeshi, additional, Iovane, Valentina, additional, Iovanna, Juan L., additional, Ip, Nancy Y., additional, Isaka, Yoshitaka, additional, Ishida, Hiroyuki, additional, Isidoro, Ciro, additional, Isobe, Ken-ichi, additional, Iwasaki, Akiko, additional, Izquierdo, Marta, additional, Izumi, Yotaro, additional, Jaakkola, Panu M., additional, Jäättelä, Marja, additional, Jackson, George R., additional, Jackson, William T., additional, Janji, Bassam, additional, Jendrach, Marina, additional, Jeon, Ju-Hong, additional, Jeung, Eui-Bae, additional, Jiang, Hong, additional, Jiang, Hongchi, additional, Jiang, Jean X., additional, Jiang, Ming, additional, Jiang, Qing, additional, Jiang, Xuejun, additional, Jiménez, Alberto, additional, Jin, Meiyan, additional, Jin, Shengkan V., additional, Joe, Cheol O., additional, Johansen, Terje, additional, Johnson, Daniel E., additional, Johnson, Gail V.W., additional, Jones, Nicola L., additional, Joseph, Bertrand, additional, Joseph, Suresh K., additional, Joubert, Annie M., additional, Juillerat-Jeanneret, Lucienne, additional, Jung, Chang Hwa, additional, Jung, Yong-Keun, additional, Kaarniranta, Kai, additional, Kaasik, Allen, additional, Kabuta, Tomohiro, additional, Kadowaki, Motoni, additional, Kågedal, Katarina, additional, Kamada, Yoshiaki, additional, Kaminskyy, Vitaliy O., additional, Kampinga, Harm H., additional, Kanamori, Hiromitsu, additional, Kang, Chanhee, additional, Kang, Khong Bee, additional, Kang, Kwang Il, additional, Kang, Rui, additional, Kang, Yoon-A, additional, Kanki, Tomotake, additional, Kanneganti, Thirumala-Devi, additional, Kanno, Haruo, additional, Kanthasamy, Anumantha G., additional, Kanthasamy, Arthi, additional, Karantza, Vassiliki, additional, Kaushal, Gur P., additional, Kaushik, Susmita, additional, Kawazoe, Yoshinori, additional, Ke, Po-Yuan, additional, Kehrl, John H., additional, Kelekar, Ameeta, additional, Kerkhoff, Claus, additional, Kessel, David H., additional, Khalil, Hany, additional, Kiel, Jan A.K.W., additional, Kiger, Amy A., additional, Kihara, Akio, additional, Kim, Deok Ryong, additional, Kim, Do-Hyung, additional, Kim, Dong-Hou, additional, Kim, Eun-Kyoung, additional, Kim, Hyung-Ryong, additional, Kim, Jae-Sung, additional, Kim, Jeong Hun, additional, Kim, Jin Cheon, additional, Kim, John K., additional, Kim, Peter K., additional, Kim, Seong Who, additional, Kim, Yong-Sun, additional, Kim, Yonghyun, additional, Kimchi, Adi, additional, Kimmelman, Alec C., additional, King, Jason S., additional, Kinsella, Timothy J., additional, Kirkin, Vladimir, additional, Kirshenbaum, Lorrie A., additional, Kitamoto, Katsuhiko, additional, Kitazato, Kaio, additional, Klein, Ludger, additional, Klimecki, Walter T., additional, Klucken, Jochen, additional, Knecht, Erwin, additional, Ko, Ben C.B., additional, Koch, Jan C., additional, Koga, Hiroshi, additional, Koh, Jae-Young, additional, Koh, Young Ho, additional, Koike, Masato, additional, Komatsu, Masaaki, additional, Kominami, Eiki, additional, Kong, Hee Jeong, additional, Kong, Wei-Jia, additional, Korolchuk, Viktor I., additional, Kotake, Yaichiro, additional, Koukourakis, Michael I., additional, Flores, Juan B. Kouri, additional, Kovács, Attila L., additional, Kraft, Claudine, additional, Krainc, Dimitri, additional, Krämer, Helmut, additional, Kretz-Remy, Carole, additional, Krichevsky, Anna M., additional, Kroemer, Guido, additional, Krüger, Rejko, additional, Krut, Oleg, additional, Ktistakis, Nicholas T., additional, Kuan, Chia-Yi, additional, Kucharczyk, Roza, additional, Kumar, Ashok, additional, Kumar, Raj, additional, Kumar, Sharad, additional, Kundu, Mondira, additional, Kung, Hsing-Jien, additional, Kurz, Tino, additional, Kwon, Ho Jeong, additional, La Spada, Albert R., additional, Lafont, Frank, additional, Lamark, Trond, additional, Landry, Jacques, additional, Lane, Jon D., additional, Lapaquette, Pierre, additional, Laporte, Jocelyn F., additional, László, Lajos, additional, Lavandero, Sergio, additional, Lavoie, Josée N., additional, Layfield, Robert, additional, Lazo, Pedro A., additional, Le, Weidong, additional, Le Cam, Laurent, additional, Ledbetter, Daniel J., additional, Lee, Alvin J.X., additional, Lee, Byung-Wan, additional, Lee, Gyun Min, additional, Lee, Jongdae, additional, lee, Ju-hyun, additional, Lee, Michael, additional, Lee, Myung-Shik, additional, Lee, Sug Hyung, additional, Leeuwenburgh, Christiaan, additional, Legembre, Patrick, additional, Legouis, Renaud, additional, Lehmann, Michael, additional, Lei, Huan-Yao, additional, Lei, Qun-Ying, additional, Leib, David A., additional, Leiro, José, additional, Lemasters, John J., additional, Lemoine, Antoinette, additional, Lesniak, Maciej S., additional, Lev, Dina, additional, Levenson, Victor V., additional, Levine, Beth, additional, Levy, Efrat, additional, Li, Faqiang, additional, Li, Jun-Lin, additional, Li, Lian, additional, Li, Sheng, additional, Li, Weijie, additional, Li, Xue-Jun, additional, Li, Yan-Bo, additional, Li, Yi-Ping, additional, Liang, Chengyu, additional, Liang, Qiangrong, additional, Liao, Yung-Feng, additional, Liberski, Pawel P., additional, Lieberman, Andrew, additional, Lim, Hyunjung J., additional, Lim, Kah-Leong, additional, Lim, Kyu, additional, Lin, Chiou-Feng, additional, Lin, Fu-Cheng, additional, Lin, Jian, additional, Lin, Jiandie D., additional, Lin, Kui, additional, Lin, Wan-Wan, additional, Lin, Weei-Chin, additional, Lin, Yi-Ling, additional, Linden, Rafael, additional, Lingor, Paul, additional, Lippincott-Schwartz, Jennifer, additional, Lisanti, Michael P., additional, Liton, Paloma B., additional, Liu, Bo, additional, Liu, Chun-Feng, additional, Liu, Kaiyu, additional, Liu, Leyuan, additional, Liu, Qiong A., additional, Liu, Wei, additional, Liu, Young-Chau, additional, Liu, Yule, additional, Lockshin, Richard A., additional, Lok, Chun-Nam, additional, Lonial, Sagar, additional, Loos, Benjamin, additional, Lopez-Berestein, Gabriel, additional, López-Otín, Carlos, additional, Lossi, Laura, additional, Lotze, Michael T., additional, Low, Peter, additional, Lu, Binfeng, additional, Lu, Bingwei, additional, Lu, Bo, additional, Lu, Zhen, additional, Luciano, Fréderic, additional, Lukacs, Nicholas W., additional, Lund, Anders H., additional, Lynch-Day, Melinda A., additional, Ma, Yong, additional, Macian, Fernando, additional, MacKeigan, Jeff P., additional, Macleod, Kay F., additional, Madeo, Frank, additional, Maiuri, Luigi, additional, Maiuri, Maria Chiara, additional, Malagoli, Davide, additional, Malicdan, May Christine V., additional, Malorni, Walter, additional, Man, Na, additional, Mandelkow, Eva-Maria, additional, Manon, Stephen, additional, Manov, Irena, additional, Mao, Kai, additional, Mao, Xiang, additional, Mao, Zixu, additional, Marambaud, Philippe, additional, Marazziti, Daniela, additional, Marcel, Yves L., additional, Marchbank, Katie, additional, Marchetti, Piero, additional, Marciniak, Stefan J., additional, Marcondes, Mateus, additional, Mardi, Mohsen, additional, Marfe, Gabriella, additional, Mariño, Guillermo, additional, Markaki, Maria, additional, Marten, Mark R., additional, Martin, Seamus J., additional, Martinand-Mari, Camille, additional, Martinet, Wim, additional, Martinez-Vicente, Marta, additional, Masini, Matilde, additional, Matarrese, Paola, additional, Matsuo, Saburo, additional, Matteoni, Raffaele, additional, Mayer, Andreas, additional, Mazure, Nathalie M., additional, McConkey, David J., additional, McConnell, Melanie J., additional, McDermott, Catherine, additional, McDonald, Christine, additional, McInerney, Gerald M., additional, McKenna, Sharon L., additional, McLaughlin, BethAnn, additional, McLean, Pamela J., additional, McMaster, Christopher R., additional, McQuibban, G. Angus, additional, Meijer, Alfred J., additional, Meisler, Miriam H., additional, Meléndez, Alicia, additional, Melia, Thomas J., additional, Melino, Gerry, additional, Mena, Maria A., additional, Menendez, Javier A., additional, Menna-Barreto, Rubem F. S., additional, Menon, Manoj B., additional, Menzies, Fiona M., additional, Mercer, Carol A., additional, Merighi, Adalberto, additional, Merry, Diane E., additional, Meschini, Stefania, additional, Meyer, Christian G., additional, Meyer, Thomas F., additional, Miao, Chao-Yu, additional, Miao, Jun-Ying, additional, Michels, Paul A.M., additional, Michiels, Carine, additional, Mijaljica, Dalibor, additional, Milojkovic, Ana, additional, Minucci, Saverio, additional, Miracco, Clelia, additional, Miranti, Cindy K., additional, Mitroulis, Ioannis, additional, Miyazawa, Keisuke, additional, Mizushima, Noboru, additional, Mograbi, Baharia, additional, Mohseni, Simin, additional, Molero, Xavier, additional, Mollereau, Bertrand, additional, Mollinedo, Faustino, additional, Momoi, Takashi, additional, Monastyrska, Iryna, additional, Monick, Martha M., additional, Monteiro, Mervyn J., additional, Moore, Michael N., additional, Mora, Rodrigo, additional, Moreau, Kevin, additional, Moreira, Paula I., additional, Moriyasu, Yuji, additional, Moscat, Jorge, additional, Mostowy, Serge, additional, Mottram, Jeremy C., additional, Motyl, Tomasz, additional, Moussa, Charbel E.-H., additional, Müller, Sylke, additional, Muller, Sylviane, additional, Münger, Karl, additional, Münz, Christian, additional, Murphy, Leon O., additional, Murphy, Maureen E., additional, Musarò, Antonio, additional, Mysorekar, Indira, additional, Nagata, Eiichiro, additional, Nagata, Kazuhiro, additional, Nahimana, Aimable, additional, Nair, Usha, additional, Nakagawa, Toshiyuki, additional, Nakahira, Kiichi, additional, Nakano, Hiroyasu, additional, Nakatogawa, Hitoshi, additional, Nanjundan, Meera, additional, Naqvi, Naweed I., additional, Narendra, Derek P., additional, Narita, Masashi, additional, Navarro, Miguel, additional, Nawrocki, Steffan T., additional, Nazarko, Taras Y., additional, Nemchenko, Andriy, additional, Netea, Mihai G., additional, Neufeld, Thomas P., additional, Ney, Paul A., additional, Nezis, Ioannis P., additional, Nguyen, Huu Phuc, additional, Nie, Daotai, additional, Nishino, Ichizo, additional, Nislow, Corey, additional, Nixon, Ralph A., additional, Noda, Takeshi, additional, Noegel, Angelika A., additional, Nogalska, Anna, additional, Noguchi, Satoru, additional, Notterpek, Lucia, additional, Novak, Ivana, additional, Nozaki, Tomoyoshi, additional, Nukina, Nobuyuki, additional, Nürnberger, Thorsten, additional, Nyfeler, Beat, additional, Obara, Keisuke, additional, Oberley, Terry D., additional, Oddo, Salvatore, additional, Ogawa, Michinaga, additional, Ohashi, Toya, additional, Okamoto, Koji, additional, Oleinick, Nancy L., additional, Oliver, F. Javier, additional, Olsen, Laura J., additional, Olsson, Stefan, additional, Opota, Onya, additional, Osborne, Timothy F., additional, Ostrander, Gary K., additional, Otsu, Kinya, additional, Ou, Jing-hsiung James, additional, Ouimet, Mireille, additional, Overholtzer, Michael, additional, Ozpolat, Bulent, additional, Paganetti, Paolo, additional, Pagnini, Ugo, additional, Pallet, Nicolas, additional, Palmer, Glen E., additional, Palumbo, Camilla, additional, Pan, Tianhong, additional, Panaretakis, Theocharis, additional, Pandey, Udai Bhan, additional, Papackova, Zuzana, additional, Papassideri, Issidora, additional, Paris, Irmgard, additional, Park, Junsoo, additional, Park, Ohkmae K., additional, Parys, Jan B., additional, Parzych, Katherine R., additional, Patschan, Susann, additional, Patterson, Cam, additional, Pattingre, Sophie, additional, Pawelek, John M., additional, Peng, Jianxin, additional, Perlmutter, David H., additional, Perrotta, Ida, additional, Perry, George, additional, Pervaiz, Shazib, additional, Peter, Matthias, additional, Peters, Godefridus J., additional, Petersen, Morten, additional, Petrovski, Goran, additional, Phang, James M., additional, Piacentini, Mauro, additional, Pierre, Philippe, additional, Pierrefite-Carle, Valérie, additional, Pierron, Gérard, additional, Pinkas-Kramarski, Ronit, additional, Piras, Antonio, additional, Piri, Natik, additional, Platanias, Leonidas C., additional, Pöggeler, Stefanie, additional, Poirot, Marc, additional, Poletti, Angelo, additional, Poüs, Christian, additional, Pozuelo-Rubio, Mercedes, additional, Prætorius-Ibba, Mette, additional, Prasad, Anil, additional, Prescott, Mark, additional, Priault, Muriel, additional, Produit-Zengaffinen, Nathalie, additional, Progulske-Fox, Ann, additional, Proikas-Cezanne, Tassula, additional, Przedborski, Serge, additional, Przyklenk, Karin, additional, Puertollano, Rosa, additional, Puyal, Julien, additional, Qian, Shu-Bing, additional, Qin, Liang, additional, Qin, Zheng-Hong, additional, Quaggin, Susan E., additional, Raben, Nina, additional, Rabinowich, Hannah, additional, Rabkin, Simon W., additional, Rahman, Irfan, additional, Rami, Abdelhaq, additional, Ramm, Georg, additional, Randall, Glenn, additional, Randow, Felix, additional, Rao, V. Ashutosh, additional, Rathmell, Jeffrey C., additional, Ravikumar, Brinda, additional, Ray, Swapan K., additional, Reed, Bruce H., additional, Reed, John C., additional, Reggiori, Fulvio, additional, Régnier-Vigouroux, Anne, additional, Reichert, Andreas S., additional, Reiners, Jr., John J., additional, Reiter, Russel J., additional, Ren, Jun, additional, Revuelta, José L., additional, Rhodes, Christopher J., additional, Ritis, Konstantinos, additional, Rizzo, Elizete, additional, Robbins, Jeffrey, additional, Roberge, Michel, additional, Roca, Hernan, additional, Roccheri, Maria C., additional, Rocchi, Stephane, additional, Rodemann, H. Peter, additional, Rodríguez de Córdoba, Santiago, additional, Rohrer, Bärbel, additional, Roninson, Igor B., additional, Rosen, Kirill, additional, Rost-Roszkowska, Magdalena M., additional, Rouis, Mustapha, additional, Rouschop, Kasper M.A., additional, Rovetta, Francesca, additional, Rubin, Brian P., additional, Rubinsztein, David C., additional, Ruckdeschel, Klaus, additional, Rucker, Edmund B., additional, Rudich, Assaf, additional, Rudolf, Emil, additional, Ruiz-Opazo, Nelson, additional, Russo, Rossella, additional, Rusten, Tor Erik, additional, Ryan, Kevin M., additional, Ryter, Stefan W., additional, Sabatini, David M., additional, Sadoshima, Junichi, additional, Saha, Tapas, additional, Saitoh, Tatsuya, additional, Sakagami, Hiroshi, additional, Sakai, Yasuyoshi, additional, Salekdeh, Ghasem Hoseini, additional, Salomoni, Paolo, additional, Salvaterra, Paul M., additional, Salvesen, Guy, additional, Salvioli, Rosa, additional, Sanchez, Anthony M.J., additional, Sánchez-Alcázar, José A., additional, Sánchez-Prieto, Ricardo, additional, Sandri, Marco, additional, Sankar, Uma, additional, Sansanwal, Poonam, additional, Santambrogio, Laura, additional, Saran, Shweta, additional, Sarkar, Sovan, additional, Sarwal, Minnie, additional, Sasakawa, Chihiro, additional, Sasnauskiene, Ausra, additional, Sass, Miklós, additional, Sato, Ken, additional, Sato, Miyuki, additional, Schapira, Anthony H.V., additional, Scharl, Michael, additional, Schätzl, Hermann M., additional, Scheper, Wiep, additional, Schiaffino, Stefano, additional, Schneider, Claudio, additional, Schneider, Marion E., additional, Schneider-Stock, Regine, additional, Schoenlein, Patricia V., additional, Schorderet, Daniel F., additional, Schüller, Christoph, additional, Schwartz, Gary K., additional, Scorrano, Luca, additional, Sealy, Linda, additional, Seglen, Per O., additional, Segura-Aguilar, Juan, additional, Seiliez, Iban, additional, Seleverstov, Oleksandr, additional, Sell, Christian, additional, Seo, Jong Bok, additional, Separovic, Duska, additional, Setaluri, Vijayasaradhi, additional, Setoguchi, Takao, additional, Settembre, Carmine, additional, Shacka, John J., additional, Shanmugam, Mala, additional, Shapiro, Irving M., additional, Shaulian, Eitan, additional, Shaw, Reuben J., additional, Shelhamer, James H., additional, Shen, Han-Ming, additional, Shen, Wei-Chiang, additional, Sheng, Zu-Hang, additional, Shi, Yang, additional, Shibuya, Kenichi, additional, Shidoji, Yoshihiro, additional, Shieh, Jeng-Jer, additional, Shih, Chwen-Ming, additional, Shimada, Yohta, additional, Shimizu, Shigeomi, additional, Shintani, Takahiro, additional, Shirihai, Orian S., additional, Shore, Gordon C., additional, Sibirny, Andriy A., additional, Sidhu, Stan B., additional, Sikorska, Beata, additional, Silva-Zacarin, Elaine C.M., additional, Simmons, Alison, additional, Simon, Anna Katharina, additional, Simon, Hans-Uwe, additional, Simone, Cristiano, additional, Simonsen, Anne, additional, Sinclair, David A., additional, Singh, Rajat, additional, Sinha, Debasish, additional, Sinicrope, Frank A., additional, Sirko, Agnieszka, additional, Siu, Parco M., additional, Sivridis, Efthimios, additional, Skop, Vojtech, additional, Skulachev, Vladimir P., additional, Slack, Ruth S., additional, Smaili, Soraya S., additional, Smith, Duncan R., additional, Soengas, Maria S., additional, Soldati, Thierry, additional, Song, Xueqin, additional, Sood, Anil K., additional, Soong, Tuck Wah, additional, Sotgia, Federica, additional, Spector, Stephen A., additional, Spies, Claudia D., additional, Springer, Wolfdieter, additional, Srinivasula, Srinivasa M., additional, Stefanis, Leonidas, additional, Steffan, Joan S., additional, Stendel, Ruediger, additional, Stenmark, Harald, additional, Stephanou, Anastasis, additional, Stern, Stephan T., additional, Sternberg, Cinthya, additional, Stork, Björn, additional, Strålfors, Peter, additional, Subauste, Carlos S., additional, Sui, Xinbing, additional, Sulzer, David, additional, Sun, Jiaren, additional, Sun, Shi-Yong, additional, Sun, Zhi-Jun, additional, Sung, Joseph J.Y., additional, Suzuki, Kuninori, additional, Suzuki, Toshihiko, additional, Swanson, Michele S., additional, Swanton, Charles, additional, Sweeney, Sean T., additional, Sy, Lai-King, additional, Szabadkai, György, additional, Tabas, Ira, additional, Taegtmeyer, Heinrich, additional, Tafani, Marco, additional, Takács-Vellai, Krisztina, additional, Takano, Yoshitaka, additional, Takegawa, Kaoru, additional, Takemura, Genzou, additional, Takeshita, Fumihiko, additional, Talbot, Nicholas J., additional, Tan, Kevin S.W., additional, Tanaka, Keiji, additional, Tanaka, Kozo, additional, Tang, Daolin, additional, Tang, Dingzhong, additional, Tanida, Isei, additional, Tannous, Bakhos A., additional, Tavernarakis, Nektarios, additional, Taylor, Graham S., additional, Taylor, Gregory A., additional, Taylor, J. 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- 2012
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38. PINK1-parkin-dependent mitophagy involves ubiquitination of mitofusins 1 and 2: Implications for Parkinson disease pathogenesis
- Author
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Gegg, Matthew E., primary and Schapira, Anthony H.V., additional
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- 2011
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39. Silencing of PINK1 Expression Affects Mitochondrial DNA and Oxidative Phosphorylation in DOPAMINERGIC Cells
- Author
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Gegg, Matthew E., primary, Cooper, J. Mark, additional, Schapira, Anthony H. V., additional, and Taanman, Jan-Willem, additional
- Published
- 2009
- Full Text
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40. Suppression of Autoimmune Retinal Disease by Lovastatin Does Not Require Th2 Cytokine Induction
- Author
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Gegg, Matthew E., primary, Harry, Rachel, additional, Hankey, Deborah, additional, Zambarakji, Hadi, additional, Pryce, Gareth, additional, Baker, David, additional, Adamson, Peter, additional, Calder, Virginia, additional, and Greenwood, John, additional
- Published
- 2005
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41. Mitochondrial dysfunction associated with glucocerebrosidase deficiency
- Author
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Gegg, Matthew E. and Schapira, Anthony H.V.
- Subjects
Glucocerebrosidase ,mitophagy ,Neurology ,Parkinson's disease ,Autophagy ,Animals ,Humans ,Gaucher disease ,lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry ,Lysosome ,Article ,lcsh:RC321-571 ,Mitochondria - Abstract
The lysosomal hydrolase glucocerebrosidase (GCase) is encoded for by the GBA gene. Homozygous GBA mutations cause Gaucher disease (GD), a lysosomal storage disorder. Furthermore, homozygous and heterozygous GBA mutations are numerically the greatest genetic risk factor for developing Parkinson's disease (PD), the second most common neurodegenerative disorder. The loss of GCase activity results in impairment of the autophagy‐lysosome pathway (ALP), which is required for the degradation of macromolecules and damaged organelles. Aberrant protein handling of α-synuclein by the ALP occurs in both GD and PD. α-synuclein is the principle component of Lewy bodies, a defining hallmark of PD. Mitochondrial dysfunction is also observed in both GD and PD. In this review we will describe how mitochondria are affected following loss of GCase activity. The pathogenic mechanisms leading to mitochondria dysfunction will also be discussed, focusing on the likely inhibition of the degradation of mitochondria by the ALP, also termed mitophagy. Other pathogenic cellular processes associated with GBA mutations that might contribute, such as the unfolding of GCase in the endoplasmic reticulum, calcium dysregulation and neuroinflammation will also be described. Impairment of the ALP and mitochondria dysfunction are common pathogenic themes between GD and PD and probably explain why GBA mutations increase the risk of developing PD that is very similar to sporadic forms of the disease.
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42. Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/parkin-dependent manner upon induction of mitophagy.
- Author
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Gegg, Matthew E., Mark Cooper, J., Chau, Kai-Yin, Rojo, Manuel, Schapira, Anthony H.V., and Taanman, Jan-Willem
- Published
- 2013
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43. The role of DJ-1 complexes and catecholamine metabolism: relevance for familial and idiopathic Parkinson's disease.
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Piston D and Gegg ME
- Abstract
Competing Interests: None declared
- Published
- 2018
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44. DJ-1 is a redox sensitive adapter protein for high molecular weight complexes involved in regulation of catecholamine homeostasis.
- Author
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Piston D, Alvarez-Erviti L, Bansal V, Gargano D, Yao Z, Szabadkai G, Odell M, Puno MR, Björkblom B, Maple-Grødem J, Breuer P, Kaut O, Larsen JP, Bonn S, Møller SG, Wüllner U, Schapira AHV, and Gegg ME
- Published
- 2018
- Full Text
- View/download PDF
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