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257 results on '"Gehl, J."'

6. 1295TiP Investigation of calcium electroporation (CaEP) therapy in malignant cutaneous and subcutaneous tumours: A non-randomized phase II clinical trial of a novel palliative therapy

Author

Pervan, M., primary, Vissing, M., additional, Princk, H., additional, Ploeen, J., additional, Vestergaard, K., additional, Schnefeldt, M., additional, Rafaelsen, S., additional, Lindhardt, C., additional, Jensen, L.H., additional, Rody, A., additional, and Gehl, J., additional

Published
2022
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12. Electrochemotherapy in the treatment of cutaneous malignancy: Outcomes and subgroup analysis from the cumulative results from the pan-European International Network for Sharing Practice in Electrochemotherapy database for 2482 lesions in 987 patients (2008–2019)

Author

Clover, A.J.P., primary, de Terlizzi, F., additional, Bertino, G., additional, Curatolo, P., additional, Odili, J., additional, Campana, L.G., additional, Kunte, C., additional, Muir, T., additional, Brizio, M., additional, Sersa, G., additional, Pritchard Jones, R., additional, Moir, G., additional, Orlando, A., additional, Banerjee, S.M., additional, Kis, E., additional, McCaul, J.A., additional, Grischke, E.M., additional, Matteucci, P., additional, Mowatt, D., additional, Bechara, F.G., additional, Mascherini, M., additional, Lico, V., additional, Giorgione, R., additional, Seccia, V., additional, Schepler, H., additional, Pecorari, G., additional, MacKenzie Ross, A.D., additional, Bisase, B., additional, and Gehl, J., additional

Published
2020
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14. Electrochemotherapy as an adjunct to the surgical management of metastatic melanoma: experience of the inspECT group (2008 to 2018)

Author

Odili, J., primary, Kunte, C., additional, Clover, J., additional, Bertino, G., additional, Campana, L., additional, Muir, T., additional, Liew, S.W., additional, Moir, G., additional, Orlando, A., additional, Kis, E., additional, Mowatt, D., additional, Saxinger, W., additional, Quaglino, P., additional, Sersa, G., additional, Curatolo, P., additional, Bechara, F., additional, Rutkowski, P., additional, De Cian, F., additional, Matteucci, P., additional, and Gehl, J., additional

Published
2019
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15. Basal cell carcinoma and electrochemotherapy: the InspECT experience

Author

Bertino, G., primary, Di Felice, S., additional, De Terlizzi, F., additional, Muir, T., additional, Curatolo, P., additional, Rotunno, R., additional, Groselj, A., additional, Kis, E., additional, Gehl, J., additional, Clover, A.J.P., additional, Campana, L.G., additional, Moir, G., additional, Odili, J., additional, Liew, S.H., additional, Quaglino, P., additional, Kunte, C., additional, and Orlando, A., additional

Published
2019
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17. Electrochemotherapy of unresectable cutaneous tumours with reduced dosages of intravenous bleomycin: analysis of 57 patients from the International Network for Sharing Practices of Electrochemotherapy registry

Author

Rotunno, R., primary, Campana, L.G., additional, Quaglino, P., additional, de Terlizzi, F., additional, Kunte, C., additional, Odili, J., additional, Gehl, J., additional, Ribero, S., additional, Liew, S.H., additional, Marconato, R., additional, Brizio, M., additional, and Curatolo, P., additional

Published
2017
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18. A love letter to the British people

Author

Alessi, D, Aspect, A, Assayas, O, Assayas, M, Auersperg, C, Auvray, C, Bacri, J, Baena, L, Balague, G, Barry, S, Baye, N, Betsen, S, Bier, S, Blanc, R, Blom, P, Bowe, T, Brendel, A, Buijs, M, Burgalat, B, Camilleri, A, CǍrtǍrescu, M, Cercas, J, Claudel, P, Clavier, C, Clevers, H, Corbijn, A, Canós, A, Pierre, J, Dardenne, L, Dehaene, S, Delpy, J, Dolan, R, Dubugnon, R, Dumont, C, Early, K, Ferrante, E, Friederici, A, Frith, U, Fudakowski, P, Gamberale, C, Garcia, N, Gavras, C, Gavras, J, Gehl, J, Giordano, P, Goedert, M, Gorris, M, Gunning-Schepers, L, Hansen, J, Hari, R, Hässer, M, Hauser, H, Helin, S, Heller, A, Hochgatterer, P, Hohn, B, Holland, A, Honigstein, R, Houllier, G, Jelinek, E, De Juan, J, Kosslick, D, Lambert, C, Lanthimos, Y, Larqué, J, Leboeuf, F, Leclerc, M, Lemaitre, P, Lockwood, D, Loukos, Y, Löwe, J, Mak, G, Mangan, A, Marcotti, G, Marcovics, K, Marías, J, Mertesacker, P, Miesenböck, G, Mikloško, L, Mouglalis, A, Mouskouri, N, Müller, H, Olsen, M, O'Neill, J, Pender-Ecki, K, Peti-Bon, P, Piano, R, Piras, A, Poésy, C, Price, A, Pulsinger, P, Puschnig, W, Rabinovici, D, Rabinowich, J, Recoing, A, Reinhardt, É, Reitz, E, Riedle, K, Riemann, K, and Kan, A

Published
2016

21. Electrochemotherapy for breast cancer - results from the INSPECT database

Author

Matthiessen, L.W., primary, Keshtgar, M., additional, Kunte, C., additional, Grischke, E.-M., additional, Odili, J., additional, Muir, T., additional, Curatolo, P., additional, Mowatt, D., additional, Clover, J., additional, Liew, S.H., additional, Hansen, H.F., additional, Newby, J., additional, Letulé, V., additional, Stauss, E., additional, Humphreys, A.C., additional, Banerjee, S., additional, Klein, A., additional, de Terlizzi, F., additional, and Gehl, J., additional

Published
2016
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23. Electrochemotherapy of unresectable cutaneous tumours with reduced dosages of intravenous bleomycin: analysis of 57 patients from the International Network for Sharing Practices of Electrochemotherapy registry.

Author

Rotunno, R., Campana, L. G., Quaglino, P., De Terlizzi, F., Kunte, C., Odili, J., Gehl, J., Ribero, S., Liew, S. H., Marconato, R., Brizio, M., and Curatolo, P.

Subjects
CUTANEOUS glands, CANCER chemotherapy, BLEOMYCIN, DRUG toxicity, MELANOMA, TUMOR treatment, PATIENTS, THERAPEUTICS, TUMORS
Abstract

Abstract: Background: Electrochemotherapy (ECT) is currently used to treat unresectable superficial tumours of different histotypes through the combination of cytotoxic chemotherapy and local application of electric pulses. In 2006, a collaborative project defined the ESOPE (European Standard Operating Procedures of Electrochemotherapy) guidelines to standardize the procedure. The International Network for Sharing Practices of Electrochemotherapy (InspECT) aims to refine the ESOPE and improve clinical practice. Limiting patient exposure to systemic chemotherapy would be advisable to ameliorate ECT safety profile. Objective: The aim of this study was to evaluate the efficacy and toxicity of ECT with reduced chemotherapy dosages. Methods: In a retrospective analysis of a prospectively maintained database (InspECT registry), we evaluated the outcome of patients who received ECT with reduced dosages of bleomycin (7500, 10 000 or 13 500 IU/m2, instead of the standard dose of 15 000 IU/m2). Tumour response in melanoma patients was compared with melanoma patients of the InspECT registry who received the standard dose of bleomycin. Results: We identified 57 patients with 147 tumours (melanoma, 38.6%; squamous cell carcinoma, 22.8%; basal cell carcinoma, 17.5%; breast cancer 7%; Kaposi sarcoma 7%; other histotypes, 7.1%). Per‐tumour complete response (CR) rate at 60 days was 70.1% (partial, 16.3%); per‐patient CR was 57.9% (partial, 21.1%). Local pain was the most frequently reported side‐effect (n = 22 patients [39%]), mostly mild; two patients experienced flu‐like symptoms, one patient nausea. We observed the same CR rate (55%) in patients with melanoma treated by reduced or conventional bleomycin dosages (P = 1.00). Conclusions: Electrochemotherapy performed with reduced bleomycin dosages could be as effective as with currently recommended dose. Patients with impaired renal function or candidate to multiple ECT cycles could benefit from a reduced dose protocol. Our findings need prospective confirmation before being adopted in clinical practice. [ABSTRACT FROM AUTHOR]

Published
2018
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24. Calcium electroporation for treatment of cutaneous metastases; a randomized double-blinded phase II study, comparing the effect of calcium electroporation with electrochemotherapy.

Author

Falk, H., Matthiessen, L. W., Wooler, G., and Gehl, J.

Subjects
BREAST tumor treatment, CALCIUM, MELANOMA treatment, METASTASIS, CANCER treatment, BIOPSY, ELECTROTHERAPEUTICS, BLEOMYCIN, EXUDATES & transudates, ITCHING, SKIN tumors, ULCERS, RANDOMIZED controlled trials, TREATMENT effectiveness, HYPERPIGMENTATION, TUMOR treatment, THERAPEUTICS
Abstract

Background:Calcium electroporation is a novel anticancer treatment, which utilizes high voltage pulses to permeabilize cell membranes and expose the cell to supraphysiological doses of calcium. Preclinical studies on calcium electroporation have shown strikingly high tumor response with cell necrosis. Calcium electroporation builds on the treatment electrochemotherapy, where chemotherapeutic drugs, mostly bleomycin, are internalized by electroporation. This double-blinded randomized study compared calcium electroporation to electrochemotherapy in terms of objective response measured 6 months after treatment. Methods:Seven patients with a total of 47 cutaneous metastases from breast cancer and malignant melanoma were included in the protocol. A total of 37 metastases were randomized and evaluated for response, another 10 metastases were used for biopsy. This was a non-inferiority trial and metastases were randomized individually in each patient to either intratumoral calcium or bleomycin followed by application of electric pulses to tumor site. All metastases were treated once, and after 6-months of follow-up, the randomization code was revealed. Results:Objective response of calcium electroporation was 72% (13/18) with complete response in 66% (12/18). For electrochemotherapy, objective response was 84% (16/19) with complete response in 68% (13/19). There was no statistically significant difference between the two treatments (p = 0.5). After 1 year, only three out of 25 metastases had relapsed. Ulceration, itching and exudation were reported slightly more frequently in metastases treated with bleomycin, and hyperpigmentation was only seen in metastases treated with bleomycin. Conclusion:This study shows that calcium electroporation is feasible and effective in patients with cutaneous metastases. [ABSTRACT FROM AUTHOR]

Published
2018
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25. Electrochemotherapy in the treatment of metastatic malignant melanoma: a prospective cohort study by InspECT.

Author

Kunte, C., Letulé, V., Gehl, J., Dahlstroem, K., Curatolo, P., Rotunno, R., Muir, T., Occhini, A., Bertino, G., Powell, B., Saxinger, W., Lechner, G., Liew, S. ‐ H., Pritchard ‐ Jones, R., Rutkowski, P., Zdzienicki, M., Mowatt, D., Sykes, A.J., Orlando, A., and Mitsala, G.

Subjects
MELANOMA treatment, METASTASIS, CANCER treatment, CANCER chemotherapy, ELECTROTHERAPEUTICS, BLEOMYCIN, FOLLOW-up studies (Medicine), THERAPEUTICS
Abstract

Background ( ECT) is an effective local treatment for cutaneous metastasis. Treatment involves the administration of chemotherapeutic drugs followed by delivery of electrical pulses to the tumour. Objectives To investigate the effectiveness of ECT in cutaneous metastases of melanoma and to identify factors that affect (beneficially or adversely) the outcome. Methods Thirteen cancer centres in the International Network for Sharing Practices on Electrochemotherapy consecutively and prospectively uploaded data to a common database. ECT consisted of intratumoral or intravenous injection of bleomycin, followed by application of electric pulses under local or general anaesthesia. Results In total, 151 patients with metastatic melanoma were identified from the database, 114 of whom had follow-up data of 60 days or more. Eighty-four of these patients (74%) experienced an overall response ( OR = complete response + partial response). Overall, 394 lesions were treated, of which 306 (78%) showed OR, with 229 showing complete response (58%). In multivariate analysis, factors positively associated with overall response were coverage of deep margins, absence of visceral metastases, presence of lymphoedema and treatment of nonirradiated areas. Factors significantly associated with complete response to ECT treatment were coverage of deep margins, previous irradiation of the treated area and tumour size (< 3 cm). One-year overall survival in this cohort of patients was 67% (95% confidence interval 57-77%), while melanoma-specific survival was 74% (95% confidence interval 64-84%). No serious adverse events were reported, and the treatment was in general very well tolerated. Conclusions ECT is a highly effective local treatment for melanoma metastases in the skin, with no severe adverse effects noted in this study. In the presence of certain clinical factors, ECT may be considered for local tumour control as an alternative to established local treatments, or as an adjunct to systemic treatments. [ABSTRACT FROM AUTHOR]

Published
2017
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32. Pre-clinical Experimental Therapeutics and Pharmacology

Author

Jensen, R. L., primary, Gilliespie, D., additional, Ajewung, N., additional, Faure, R., additional, Kamnasaran, D., additional, Poirier, D., additional, Tamura, K., additional, Wakimoto, H., additional, Rabkin, S. D., additional, Martuza, R. L., additional, Shah, K., additional, Hashizume, R., additional, Aoki, Y., additional, Serwer, L. P., additional, Drummond, D., additional, Noble, C., additional, Park, J., additional, Bankiewicz, K., additional, James, D. C., additional, Gupta, N., additional, Agerholm-Larsen, B., additional, Iversen, H. K., additional, Jensen, K. S., additional, Moller, J., additional, Ibsen, P., additional, Mahmood, F., additional, Gehl, J., additional, Corem, E., additional, Ram, Z., additional, Daniels, D., additional, Last, D., additional, Shneor, R., additional, Salomon, S., additional, Perlstein, B., additional, Margel, S., additional, Mardor, Y., additional, Charest, G., additional, Fortin, D., additional, Mathieu, D., additional, Sanche, L., additional, Paquette, B., additional, Li, H.-F., additional, Hariono, S., additional, Dasgupta, T., additional, Kim, J.-S., additional, Haas-Kogan, D., additional, Weiss, W. A., additional, James, C. D., additional, Waldman, T., additional, Nicolaides, T., additional, Ozawa, T., additional, Rao, S., additional, Sun, H., additional, Ng, C., additional, De La Torre, J., additional, Santos, R., additional, Prados, M., additional, Butowski, N., additional, Michaud, K., additional, Solomon, D. A., additional, Prados, M. D., additional, Pandya, H., additional, Gibo, D., additional, Debinski, W., additional, Vinchon-Petit, S., additional, Jarnet, D., additional, Jadaud, E., additional, Feuvret, L., additional, Garcion, E., additional, Menei, P., additional, Chen, R., additional, Yu, J.-C., additional, Liu, C., additional, Jaffer, Z. M., additional, Chabala, J. C., additional, Winssinger, N., additional, Rubenstein, A. E., additional, Emdad, L., additional, Kothari, H., additional, Qadeer, Z., additional, Binello, E., additional, Germano, I., additional, Hirschberg, H., additional, Baek, S.-K., additional, Kwon, Y. J., additional, Sun, C. H., additional, Li, S. C., additional, Madsen, S., additional, Liu, T., additional, Wang, S.-W., additional, Gibo, D. M., additional, Fan, Q.-W., additional, Cheng, C., additional, Hackett, C., additional, Feldman, M., additional, Houseman, B. T., additional, Oakes, S. A., additional, Debnath, J., additional, Shokat, K. M., additional, Sai, K., additional, Chen, F., additional, Qiu, Z., additional, Mou, Y., additional, Zhang, X., additional, Yang, Q., additional, Chen, Z., additional, Patel, T. R., additional, Zhou, J., additional, Piepmeier, J. M., additional, Saltzman, W. M., additional, Banerjee, S., additional, Kaul, A., additional, Gianino, S. M., additional, Christians, U., additional, Gutmann, D. H., additional, Wu, J., additional, Shen, R., additional, Puduvalli, V., additional, Koul, D., additional, Alfred Yung, W. K., additional, Yun, J., additional, Sonabend, A., additional, Stuart, M., additional, Yanagihara, T., additional, Dashnaw, S., additional, Brown, T., additional, McCormick, P., additional, Romanov, A., additional, Sebastian, M., additional, Canoll, P., additional, Bruce, J. N., additional, Piao, L., additional, Joshi, K., additional, Lee, R. J., additional, Nakano, I., additional, Madsen, S. J., additional, Chou, C. C., additional, Blickenstaff, J. W., additional, Sun, C.-H., additional, Zhou, Y.-H., additional, Tome, C. M. L., additional, Wykosky, J., additional, Palma, E., additional, Nduom, E., additional, Machaidze, R., additional, Kaluzova, M., additional, Wang, Y., additional, Nie, S., additional, Hadjipanayis, C., additional, Saito, R., additional, Nakamura, T., additional, Sonoda, Y., additional, Kumabe, T., additional, Tominaga, T., additional, Lun, X., additional, Zemp, F., additional, Zhou, H., additional, Stechishin, O., additional, Kelly, J. J., additional, Weiss, S., additional, Hamilton, M. G., additional, Cairncross, G., additional, Rabinovich, B. A., additional, Bell, J., additional, McFadden, G., additional, Senger, D. L., additional, Forsyth, P. A., additional, Kang, P., additional, Jane, E. P., additional, Premkumar, D. R., additional, Pollack, I. F., additional, Yoo, J. Y., additional, Haseley, A., additional, Bratasz, A., additional, Powell, K., additional, Chiocca, E. A., additional, Kaur, B., additional, Johns, T. G., additional, Ferruzzi, P., additional, Mennillo, F., additional, De Rosa, A., additional, Rossi, M., additional, Giordano, C., additional, Magrini, R., additional, Benedetti, G., additional, Pericot, G. l., additional, Magnoni, L., additional, Mori, E., additional, Thomas, R., additional, Tunici, P., additional, Bakker, A., additional, Pradarelli, J., additional, Kaka, A., additional, Alvarez-Breckenridge, C., additional, Pan, Q., additional, Teknos, T., additional, Cen, L., additional, Ostrem, J. L., additional, Schroeder, M. A., additional, Mladek, A. C., additional, Fink, S. R., additional, Jenkins, R. B., additional, Sarkaria, J. N., additional, Madhankumar, A. B., additional, Slagle-Webb, B., additional, Park, A., additional, Pang, M., additional, Klinger, M., additional, Harbaugh, K. S., additional, Sheehan, J. M., additional, Connor, J. R., additional, Chen, T. C., additional, Wang, W., additional, Hofman, F. M., additional, Drummond, D. C., additional, Noble, C. O., additional, Park, J. W., additional, Zhou, Y., additional, Marks, J. D., additional, Alonso, M. M., additional, Gomez-Manzano, C., additional, Cortes-Santiago, N., additional, Roche, F. P., additional, Fueyo, J., additional, Johannessen, T.-C. A., additional, Grudic, A., additional, Tysnes, B. B., additional, Nigro, J., additional, Bjerkvig, R., additional, Joshi, A. D., additional, Parsons, W., additional, Velculescu, V. E., additional, Riggins, G. J., additional, Bindra, R. S., additional, Jasin, M., additional, Powell, S. N., additional, Fu, J., additional, Shen, R.-J., additional, Colman, H., additional, Lang, F. F., additional, Jensen, M. R., additional, Friedman, G. K., additional, Haas, M., additional, Cassady, K. A., additional, Gillespie, G. Y., additional, Nguyen, V., additional, Murphy, L. T., additional, Beauchamp, A. S., additional, Hollingsworth, C. K., additional, Mintz, A., additional, Garg, S., additional, Kridel, S., additional, Conrad, C. A., additional, Madden, T., additional, Ji, Y., additional, Priebe, W., additional, Seleverstov, O., additional, Purow, B. W., additional, Grant, G. A., additional, Wilson, C., additional, Campbell, M., additional, Humphries, P., additional, Li, S., additional, Li, J., additional, Johnson, A., additional, Bigner, D., additional, Dewhirst, M., additional, Pokorny, J. L., additional, Kitange, G. J., additional, Carlson, B. L., additional, Suphangul, M., additional, Petro, B., additional, Mukhtar, L., additional, Baig, M. S., additional, Villano, J., additional, Mahmud, N., additional, Keir, S. T., additional, Reardon, D. A., additional, Watson, M., additional, Shore, G. C., additional, Bigner, D. D., additional, Friedman, H. S., additional, and Gururangan, S., additional

Published
2010
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36. Efficiency of High- and Low-Voltage Pulse Combinations for Gene Electrotransfer in Muscle, Liver, Tumor, and Skin

Author

André, F.M., primary, Gehl, J., additional, Sersa, G., additional, Préat, V., additional, Hojman, P., additional, Eriksen, J., additional, Golzio, M., additional, Cemazar, M., additional, Pavselj, N., additional, Rols, M.-P., additional, Miklavcic, D., additional, Neumann, E., additional, Teissié, J., additional, and Mir, L.M., additional

Published
2008
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48. A love letter to the British people [1]

Author

Alessi, D., Aspect, A., Assayas, O., Assayas, M., Auersperg, C., Auvray, C., Bacri, J. -P, Baena, L., Balague, G., Barry, S., Baye, N., Betsen, S., Bier, S., Blanc, R., Blom, P., Bowe, T., Brendel, A., Buijs, M., Burgalat, B., Camilleri, A., Cǎrtǎrescu, M., Cercas, J., Claudel, P., Clavier, C., Clevers, H., Corbijn, A., Canós, A. C., Pierre, J., Dardenne, L., Dehaene, S., Delpy, J., Dolan, R., Dubugnon, R., Dumont, C., Early, K., Ferrante, E., Friederici, A., Frith, U., Fudakowski, P., Gamberale, C., Garcia, N., Gavras, C., Gavras, J., Gehl, J., Giordano, P., Goedert, M., Gorris, M., Gunning-Schepers, L., Hansen, J. -P, Hari, R., Hässer, M., Hauser, H., Helin, S., Heller, A., Hochgatterer, P., Hohn, B., Holland, A., Honigstein, R., Houllier, G., Jelinek, E., Juan, J., Kosslick, D., Lambert, C., Lanthimos, Y., Larqué, J. -M, Leboeuf, F., Leclerc, M., Lemaitre, P., Lockwood, D., Loukos, Y., Löwe, J., Mak, G., Mangan, A., Marcotti, G., Marcovics, K., Marías, J., Mertesacker, P., Gero Miesenboeck, Mikloško, L., Mouglalis, A., Mouskouri, N., Müller, H., Olsen, M., O Neill, J., Pender-Ecki, K., Peti-Bon, P., Piano, R., Piras, A., Poésy, C., Price, A., Pulsinger, P., Puschnig, W., Rabinovici, D., Rabinowich, J., Recoing, A., Reinhardt, É, Reitz, E., Riedle, K. -H, Riemann, K., Kan, A. R., Rizzolatti, G., Roedelius, H. -J, Roepstorff, A., Rossellini, I., Rothen, J., Rother, M., Ruzowitzky, S., Sansonetti, P. J., Scheffler, A., Scherfig, L., Schlöndorff, V., Schultz, W., Setz, C., Seward, V., Singer, W., Skarsgård, S., Spengler, P., Spillantini, M. G., Stan, M., Südhof, T. C., Süskind, P., Szumowska, M., T Hooft, G., Tillmans, W., Tismǎneanu, V., Tóibín, C., Topalov, V., Toussaint, J. -P, Trotta, M., Uhlmann, F., Ulvaeus, B., Vachier-Lagrave, M., Warmerdam, A., Llosa, M. V., Verhoeven, P., Veronesi, S., Villani, C., Visser, T., Wajda, A., Wenger, A., Werner, W., Zaccaï, J., and Zanussi, K.

50. Electrochemotherapy: technological advancements for efficient electroporation-based treatment of internal tumors

Author

Gregor Sersa, Julie Gehl, Giuseppe Bianchi, Carlo Riccardo Rossi, Tomaz Jarm, Declan M. Soden, L.G. Campana, Pietro Ruggieri, Erik Brecelj, Damijan Miklavčič, Miklavcic D, Sersa G, BrecelJ e, Gehl J, Soden D, Bianchi G, Ruggieri P, Rossi CR, Campana LG, and Jarm T.

Subjects
Cancer treatment, Electrochemotherapy, Electroporation, Treatment planning, Endoscope, Biomedical Engineering, Review Article, Esophageal tumors, Neoplasms, endoscope, equipment, Animals, Humans, Medicine, Radiation treatment planning, Electrodes, Endoscopes, business.industry, Soft tissue, Anticancer drug, Computer Science Applications, Cancer cell, business, Biomedical engineering
Abstract

Electrochemotherapy, a combination of high voltage electric pulses and of an anticancer drug, has been demonstrated to be highly effective in treatment of cutaneous and subcutaneous tumors. Unique properties of electrochemotherapy (e.g., high specificity for targeting cancer cells, high degree of localization of treatment effect, capacity for preserving the innate immune response and the structure of the extracellular matrix) are facilitating its wide spread in the clinics. Due to high effectiveness of electrochemotherapy in treatment of cutaneous and subcutaneous tumors regardless of histological origin, there are now attempts to extend its use to treatment of internal tumors. To advance the applicability of electrochemotherapy to treatment of internal solid tumors, new technological developments are needed that will enable treatment of these tumors in daily clinical practice. New electrodes through which electric pulses are delivered to target tissue need to be designed with the aim to access target tissue anywhere in the body. To increase the probability of complete tumor eradication, the electrodes have to be accurately positioned, first to provide an adequate extent of electroporation of all tumor cells and second not to damage critical healthy tissue or organs in its vicinity. This can be achieved by image guided insertion of electrodes that will enable accurate positioning of the electrodes in combination with patient-specific numerical treatment planning or using a predefined geometry of electrodes. In order to be able to use electrochemotherapy safely for treatment of internal tumors located in relative proximity of the heart (e.g., in case of liver metastases), the treatment must be performed without interfering with the heart's electrical activity. We describe recent technological advances, which allow treatment of liver and bone metastases, soft tissue sarcomas, brain tumors, and colorectal and esophageal tumors. The first clinical experiences in these novel application areas of electrochemotherapy are also described.

Published
2012

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