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26 results on '"Gehling, Ursula M."'

10. Expression of CD133 and other putative stem cell markers in uveal melanoma

Author

Thill, Michelle, primary, Berna, Marc Jean, additional, Grierson, Rebecca, additional, Reinhart, Inna, additional, Voelkel, Tobias, additional, Piechaczek, Christoph, additional, Galambos, Peter, additional, Jager, Martine J., additional, Richard, Gisbert, additional, Lange, Claudia, additional, and Gehling, Ursula M., additional

Published
2011
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11. Radiation Rescue: Mesenchymal Stromal Cells Protect from Lethal Irradiation

Author

Lange, Claudia, primary, Brunswig-Spickenheier, Bärbel, additional, Cappallo-Obermann, Heike, additional, Eggert, Katharina, additional, Gehling, Ursula M., additional, Rudolph, Cornelia, additional, Schlegelberger, Brigitte, additional, Cornils, Kerstin, additional, Zustin, Jozef, additional, Spiess, Andrej-Nikolai, additional, and Zander, Axel R., additional

Published
2011
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13. Stromal Fibroblasts in Colorectal Liver Metastases Originate From Resident Fibroblasts and Generate an Inflammatory Microenvironment

Author

Mueller, Lars, primary, Goumas, Freya A., additional, Affeldt, Marianne, additional, Sandtner, Susanne, additional, Gehling, Ursula M., additional, Brilloff, Silke, additional, Walter, Jessica, additional, Karnatz, Nadia, additional, Lamszus, Katrin, additional, Rogiers, Xavier, additional, and Broering, Dieter C., additional

Published
2007
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14. A Novel Population of Repair Cells Identified in the Stroma of the Human Cornea

Author

Thill, Michelle, primary, Schlagner, Kathleen, additional, Altenähr, Sybille, additional, Ergün, Süleyman, additional, Faragher, Richard G.A., additional, Kilic, Nerbil, additional, Bednarz, Jürgen, additional, Vohwinkel, Gabi, additional, Rogiers, Xavier, additional, Hossfeld, Dieter K., additional, Richard, Gisbert, additional, and Gehling, Ursula M., additional

Published
2007
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17. Mobilization of Putative High-Proliferative-Potential Endothelial Colony-Forming Cells during Antihypertensive Treatment in Patients with Essential Hypertension

Author

Benndorf, Ralf A., primary, Gehling, Ursula M., additional, Appel, Daniel, additional, Maas, Renke, additional, Schwedhelm, Edzard, additional, Schlagner, Kathleen, additional, Silberhorn, Elisabeth, additional, Hossfeld, Dieter K., additional, Rogiers, Xavier, additional, and Böger, Rainer, additional

Published
2007
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20. Stem Cells: Shibboleths of Development

Author

Parker, Graham C., primary, Anastassova-Kristeva, Marlene, additional, Broxmeyer, Hal E., additional, Dodge, William H., additional, Eisenberg, Leonard M., additional, Gehling, Ursula M., additional, Guenin, Louis M., additional, Huss, Ralf, additional, Moldovan, Nicanor I., additional, Rao, Mahendra, additional, Srour, Edward F., additional, and Yoder, Mervin C., additional

Published
2004
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22. Identification of the Adult Human Hemangioblast

Author

Loges, Sonja, primary, Fehse, Boris, additional, Brockmann, Marc A., additional, Lamszus, Katrin, additional, Butzal, Martin, additional, Guckenbiehl, Markus, additional, Schuch, Gunter, additional, Ergün, Süleyman, additional, Fischer, Uta, additional, Zander, Axel R., additional, Hossfeld, Dieter K., additional, Fiedler, Walter, additional, and Gehling, Ursula M., additional

Published
2004
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23. Endothelial-like cells derived from human CD14 positive monocytes

Author

Pujol, Beatriz Fernandez, primary, Lucibello, Frances C., additional, Gehling, Ursula M., additional, Lindemann, Katharina, additional, Weidner, Natalja, additional, Zuzarte, Mary-Lou, additional, Adamkiewicz, Jürgen, additional, Elsässer, Hans-Peter, additional, Müller, Rolf, additional, and Havemann, Klaus, additional

Published
2000
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24. In vitro differentiation of endothelial cells from AC133-positive progenitor cells

Author

Gehling, Ursula M., primary, Ergün, Süleyman, additional, Schumacher, Udo, additional, Wagener, Christoph, additional, Pantel, Klaus, additional, Otte, Marcus, additional, Schuch, Gunter, additional, Schafhausen, Philippe, additional, Mende, Thorsten, additional, Kilic, Nerbil, additional, Kluge, Katrin, additional, Schäfer, Birgit, additional, Hossfeld, Dieter K., additional, and Fiedler, Walter, additional

Published
2000
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25. Myeloperoxidase mediates neutrophil activation by association with CD11b/CD 8 integrins.

Author

Lau, Denise, Mollnau, Hanke, Eiserich, Jason P., Freeman, Bruce A., Daiber, Andreas, Gehling, Ursula M., Brümmer, Jens, Rudolph, Volker, Münzel, Thomas, Heitzer, Thomas, Meinertz, Thomas, and Baldus, Stephan

Subjects
NEUTROPHILS, GRANULOCYTES, PATHOGENIC microorganisms, BLOOD vessels, INTEGRINS, GLYCOPROTEINS
Abstract

Recruitment and activation of polymorphonuclear neutrophils (PMNs) reflects a primary immunological response to invading pathogens and has also emerged as a hallmark of vascular inflammation. One of the principal enzymes released upon PMN activation is myeloperoxidase (MPO), a heme protein that not only generates cytotoxic oxidant but also impacts deleteriously on nitric oxide-dependent signaling cascades within the vasculature. Because MPO also associates with the membrane of PMN, we evaluated whether MPO could also function as an autocrine modulator of PMN activation. The extent of PMN membrane-associated MPO was elevated in patients with acute inflammatory vascular disease compared with healthy individuals. Isolated PMNs bound free MPO by a CD11b/CD18 integrin-dependent mechanism. PMNs exposed to MPO were characterized by increased tyrosine phosphorylation and p38 mitogen-activated protein kinase activation. Also, nuclear translocation of NFκB in PMN was enhanced after incubation with MPO, as was surface expression of CD11b. Binding of PMN to MPO-coated fibronectin surfaces amplified PMN degranulation, as evidenced by increased release of MPO and elastase. MPO also augmented PM N-dependent superoxide (Or) production, which was prevented by anti-CD11b antibodies, but not MPO inhibitors. Collectively, these result reveal that binding of MPO to CD11b/CD18 integrins stimulates PMN signaling pathways to induce PMN activation in a mechanism independent of MPO catalytic activity. These cytokine-like properties of MPO thus represent an additional dimension of the proinflammatory actions of MPO in vascular disease. [ABSTRACT FROM AUTHOR]

Published
2005
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