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12 results on '"Gelize, Emmanuelle"'

2. Mechanisms of macular edema: Beyond the surface

Author

Daruich, Alejandra, Matet, Alexandre, Moulin, Alexandre, Kowalczuk, Laura, Nicolas, Michaël, Sellam, Alexandre, Rothschild, Pierre-Raphaël, Omri, Samy, Gélizé, Emmanuelle, Jonet, Laurent, Delaunay, Kimberley, De Kozak, Yvonne, Berdugo, Marianne, Zhao, Min, Crisanti, Patricia, and Behar-Cohen, Francine

Published
2018
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3. Mineralocorticoid receptor antagonism limits experimental choroidal neovascularization and structural changes associated with neovascular age-related macular degeneration

Author

Zhao, Min, Mantel, Irmela, Gelize, Emmanuelle, Li, Xinxin, Xie, Xiaoyue, Arboleda, Alejandro, Seminel, Marie, Levy-Boukris, Rinath, Dernigoghossian, Marilyn, Prunotto, Andrea, Andrieu-Soler, Charlotte, Rivolta, Carlo, Canonica, Jérémie, Naud, Marie-Christine, Lechner, Sebastian, Farman, Nicolette, Bravo-Osuna, Irene, Herrero-Vanrell, Rocio, Jaisser, Frederic, and Behar-Cohen, Francine

Published
2019
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5. Mineralocorticoid Receptor Pathway and Its Antagonism in a Model of Diabetic Retinopathy

Author

Zhao, Min, primary, Gelize, Emmanuelle, additional, Levy, Rinath, additional, Moulin, Alexandre, additional, Azan, Frédéric, additional, Berdugo, Marianne, additional, Naud, Marie-Christine, additional, Guegan, Justine, additional, Delaunay, Kimberley, additional, Pussard, Eric, additional, Lassiaz, Patricia, additional, Bravo-Osuna, Irene, additional, Herrero-Vanrell, Rocio, additional, and Behar-Cohen, Francine, additional

Published
2021
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6. Les œdèmes maculaires: Mieux comprendre leurs mécanismes pour mieux les traiter

Author

Behar-Cohen, Francine, Zhao, Min, Gelize, Emmanuelle, Bousquet, Elodie, Daruich, Alejandra, Matet, Alexandre, Delaunay, Kimberley, Torriglia, Alicia, Berdugo-Polak, Marianne, Jaisser, Frédéric, de Kozak, Yvonne, Lassiaz, Patricia, Centre de Recherche des Cordeliers (CRC (UMR_S_1138 / U1138)), École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université de Paris (UP), Physiologie rénale et tubulopathies = Renal Physiology and tubulopathies [CRC], Centre National de la Recherche Scientifique (CNRS)-Centre de Recherche des Cordeliers (CRC (UMR_S_1138 / U1138)), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université de Paris (UP)-École pratique des hautes études (EPHE), Service d'ophtalmologie [CHU Necker], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Necker - Enfants Malades [AP-HP], and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)

Subjects
[SDV]Life Sciences [q-bio]
Abstract

International audience; L’œdème maculaire est une augmentation de volume de la macula, zone centrale de la rétine, responsable de l’acuité visuelle. Des symptômes visuels handicapent la vie de millions de patients atteints d’œdème maculaire secondaire à une maladie chronique et parfois aiguë de la rétine. Les protéines qui neutralisent la voie du facteur de croissance de l’endothélium vasculaire (VEGF) ou les glucocorticoïdes, au prix d’injections intraoculaires répétées pendant des années, limitent les symptômes visuels. Mieux comprendre pourquoi et comment l’œdème se forme et comment les molécules thérapeutiques exercent un effet anti-œdémateux permettra de mieux prévenir la survenue de cette complication rétinienne handicapante et cécitante.

Published
2020
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7. Glial cells of the human fovea

Author

Delaunay, Kimberley, Khamsy, Lilly, Kowalczuk, Laura, Gelize, Emmanuelle, Moulin, Alexandre, Nicolas, Michael, Zografos, Leonidas, Lassiaz, Patricia, Behar-Cohen, Francine, Centre de Recherche des Cordeliers (CRC (UMR_S_1138 / U1138)), École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université de Paris (UP), Université de Lausanne (UNIL), Fondation Asile des aveugles - Hôpital Ophtalmique Jules-Gonin [Lausanne], AP-HP - Hôpital Cochin Broca Hôtel Dieu [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), HAL-SU, Gestionnaire, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université Paris Cité (UPCité), and Université de Lausanne = University of Lausanne (UNIL)

Subjects
Male, Fovea Centralis, genetic structures, Ependymoglial Cells, MESH: Carrier Proteins, Glutamate-Ammonia Ligase, Glial Fibrillary Acidic Protein, Humans, Vimentin, MESH: Macula Lutea, MESH: Glial Fibrillary Acidic Protein, MESH: Glutamate-Ammonia Ligase, Macula Lutea, MESH: Fovea Centralis, Aged, MESH: Aged, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, MESH: Middle Aged, MESH: Humans, MESH: Immunohistochemistry, Middle Aged, MESH: Ependymoglial Cells, Immunohistochemistry, eye diseases, MESH: Male, MESH: Connexin 43, MESH: Astrocytes, Astrocytes, Connexin 43, Female, MESH: Neuroglia, MESH: Vimentin, sense organs, Carrier Proteins, Neuroglia, MESH: Female, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, Research Article
Abstract

International audience; PurposeThe exact cellular types that form the human fovea remain a subject of debate, and few studies have been conducted on human macula to solve this question. The purpose of this study was to perform immunohistochemistry on fresh human samples to characterize the glial cells that form the human fovea.MethodsImmunohistochemistry was performed using antibodies against proteins expressed in astrocytes or in retinal Müller glial cells or both types of cells on six human macula obtained from eyes enucleated for peripheral intraocular tumors and on two postmortem eyes from healthy donors. The posterior poles of the enucleated eyes were cryosectioned and stained with antibodies against the glial proteins GFAP, vimentin, CRALBP, glutamine synthetase, and connexin 43.ResultsA population of cells positive for GFAP and negative for glutamine synthetase and CRALBP that express connexin 43 were identified at the roof of the foveal pit. These cells are distinct from the Müller cone cells described by Yamada and Gass, suggesting that another type of foveal glial cells, most likely astrocytes, are present in the human fovea.ConclusionsThis study showed that in humans, astrocytic glial cells cover the foveal pit. Their roles in macula homeostasis and mechanisms of macular disease remain to be determined.

Published
2020

8. Les œdèmes maculaires

Author

Behar-Cohen, Francine, primary, Zhao, Min, additional, Gelize, Emmanuelle, additional, Bousquet, Elodie, additional, Daruich, Alejandra, additional, Alexandre, Matet, additional, Delaunay, Kimberley, additional, Torriglia, Alicia, additional, Berdugo-Polak, Marianne, additional, Jaisser, Frédéric, additional, de Kozak, Yvonne, additional, and Lassiaz, Patricia, additional

Published
2020
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9. Mechanisms of FH Protection Against Neovascular AMD

Author

Borras, Céline, primary, Delaunay, Kimberley, additional, Slaoui, Yousri, additional, Abache, Toufik, additional, Jorieux, Sylvie, additional, Naud, Marie-Christine, additional, Sanharawi, Mohamed El, additional, Gelize, Emmanuelle, additional, Lassiaz, Patricia, additional, An, Na, additional, Kowalczuk, Laura, additional, Ayassami, Cédric, additional, Moulin, Alexandre, additional, Behar-Cohen, Francine, additional, Mascarelli, Frédéric, additional, and Dinet, Virginie, additional

Published
2020
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10. ROCK-1 mediates diabetes-induced retinal pigment epithelial and endothelial cell blebbing: Contribution to diabetic retinopathy

Author

Rothschild, Pierre-Raphaël, Salah, Sawsen, Berdugo, Marianne, Gelize, Emmanuelle, Delaunay, Kimberley, Naud, Marie-Christine, Klein, Christophe, Moulin, Alexandre, Savoldelli, Michèle, Bergin, Ciara, Jeanny, Jean-Claude, Jonet, Laurent, Arsenijevic, Yvan, Behar-Cohen, Francine, Crisanti, Patricia, Assistance Publique-Hôpitaux de Paris, Department of Ophthalmology, Hôpital Cochin, Paris, France, Métabolisme et physiologie rénale (CRC - UMR_S 1138), Centre de Recherche des Cordeliers (CRC (UMR_S_1138 / U1138)), École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Physiopathologie des Maladies Oculaires : Innovations Therapeutiques, Université Pierre et Marie Curie - Paris 6 (UPMC)-IFR58-Institut National de la Santé et de la Recherche Médicale (INSERM), Service d'opthalmologie, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Hôtel-Dieu [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Department of Ophthalmology, Université de Lausanne (UNIL), Gérontologie, Institut National de la Santé et de la Recherche Médicale (INSERM), Développement, vieillissement et pathologie de la rétine, Unit of Retinal Degeneration and Regeneration, École pratique des hautes études (EPHE)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-École pratique des hautes études (EPHE)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), École pratique des hautes études (EPHE)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpital Hôtel-Dieu [Paris], Centre National de la Recherche Scientifique (CNRS)-Centre de Recherche des Cordeliers (CRC (UMR_S_1138 / U1138)), École Pratique des Hautes Études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-École Pratique des Hautes Études (EPHE), and Université de Lausanne = University of Lausanne (UNIL)

Subjects
Male, [SDV]Life Sciences [q-bio], Science, Fluorescent Antibody Technique, Retinal Pigment Epithelium, 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine/analogs & derivatives, 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine/pharmacology, Aged, Animals, Biomarkers, Case-Control Studies, Cytoskeleton/metabolism, Diabetes Mellitus, Experimental, Diabetes Mellitus, Type 2/complications, Diabetic Retinopathy/etiology, Diabetic Retinopathy/metabolism, Diabetic Retinopathy/pathology, Disease Models, Animal, Endothelial Cells/drug effects, Endothelial Cells/metabolism, Endothelial Cells/ultrastructure, Female, Humans, Hypoxia/metabolism, Immunohistochemistry, Middle Aged, Rats, Retinal Pigment Epithelium/drug effects, Retinal Pigment Epithelium/metabolism, Retinal Pigment Epithelium/pathology, Retinal Vessels/drug effects, Retinal Vessels/metabolism, Retinal Vessels/pathology, Retinal Vessels/ultrastructure, rho-Associated Kinases/genetics, rho-Associated Kinases/metabolism, Article, 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine, Hypoxia, ComputingMilieux_MISCELLANEOUS, Cytoskeleton, rho-Associated Kinases, Diabetic Retinopathy, Endothelial Cells, Retinal Vessels, eye diseases, Diabetes Mellitus, Type 2, Medicine, sense organs
Abstract

In diabetic retinopathy, the exact mechanisms leading to retinal capillary closure and to retinal barriers breakdown remain imperfectly understood. Rho-associated kinase (ROCK), an effector of the small GTPase Rho, involved in cytoskeleton dynamic regulation and cell polarity is activated by hyperglycemia. In one year-old Goto Kakizaki (GK) type 2 diabetic rats retina, ROCK-1 activation was assessed by its cellular distribution and by phosphorylation of its substrates, MYPT1 and MLC. In both GK rat and in human type 2 diabetic retinas, ROCK-1 is activated and associated with non-apoptotic membrane blebbing in retinal vessels and in retinal pigment epithelium (RPE) that respectively form the inner and the outer barriers. Activation of ROCK-1 induces focal vascular constrictions, endoluminal blebbing and subsequent retinal hypoxia. In RPE cells, actin cytoskeleton remodeling and membrane blebs in RPE cells contributes to outer barrier breakdown. Intraocular injection of fasudil, significantly reduces both retinal hypoxia and RPE barrier breakdown. Diabetes-induced cell blebbing may contribute to ischemic maculopathy and represent an intervention target.

Published
2017
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11. Mineralocorticoid receptor antagonism limits experimental choroidal neovascularization and structural changes associated with neovascular age-related macular degeneration

Author

Zhao, Min, Mantel, Irmela, Gelize, Emmanuelle, Li, Xinxin, Xie, Xiaoyue, Arboleda, Alejandro, Seminel, Marie, Levy-Boukris, Rinath, Dernigoghossian, Marilyn, Prunotto, Andrea, Andrieu-Soler, Charlotte, Rivolta, Carlo, Canonica, Jérémie, Naud, Marie-Christine, Lechner, Sebastian, Farman, Nicolette, Bravo-Osuna, Irene, Herrero-Vanrell, Rocio, Jaisser, Frederic, and Behar-Cohen, Francine

Subjects
3. Good health

12. [Macular edema: Understand mechanisms to develop treatments].

Author

Behar-Cohen F, Zhao M, Gelize E, Bousquet E, Daruich A, Matet A, Delaunay K, Torriglia A, Berdugo-Polak M, Jaisser F, de Kozak Y, and Lassiaz P

Subjects
Angiogenesis Inhibitors therapeutic use, Antibodies, Monoclonal, Humanized therapeutic use, Glucocorticoids therapeutic use, Humans, Signal Transduction drug effects, Signal Transduction physiology, Vascular Endothelial Growth Factor A antagonists & inhibitors, Vascular Endothelial Growth Factor A immunology, Visual Acuity drug effects, Visual Acuity physiology, Macular Edema etiology, Macular Edema therapy
Abstract

Macular edema is an increase in volume of the central area of the retina, responsible for visual acuity. Visual symptoms handicap the lives of millions of patients with macular edema secondary to chronic and sometimes acute retinal disease. Proteins that neutralize the vascular endothelial growth factor (VEGF) pathway or glucocorticoids, at the cost of repeated intraocular injections over years, limit visual symptoms. A better understanding of why and how edema forms and how therapeutic molecules exert an anti-edematous effect will help prevent this disabling and blinding retinal complication from occurring., (© 2020 médecine/sciences – Inserm.)

Published
2020
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