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1. Is prolonged operative time associated with postoperative complications in liver surgery? An international multicentre cohort study of 5424 patients

Author

Kuemmerli, Christoph, Sijberden, Jasper P., Cipriani, Federica, Osei-Bordom, Daniel, Aghayan, Davit, Lanari, Jacopo, de Meyere, Celine, Cacciaguerra, Andrea Benedetti, Rotellar, Fernando, Fuks, David, Liu, Rong, Besselink, Marc G., Zimmitti, Giuseppe, Ruzzenente, Andrea, di Benedetto, Fabrizio, Succandy, Iswanto, Efanov, Mikhail, Memeo, Riccardo, Jovine, Elio, Vrochides, Dionisios, Dagher, Ibrahim, Croner, Roland, Lopez-Ben, Santi, Geller, David, Ahmad, Jawad, Gallagher, Tom, White, Steven, Alseidi, Adnan, Goh, Brian K. P., Sparrelid, Ernesto, Ratti, Francesca, Marudanayagam, Ravi, Fretland, Åsmund Avdem, Vivarelli, Marco, D’Hondt, Mathieu, Cillo, Umberto, Edwin, Bjørn, Sutcliffe, Robert P., Aldrighetti, Luca A., and Hilal, Mohammed Abu

Published
2024
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2. Recurrence and tumor-related death after resection of hepatocellular carcinoma in patients with metabolic syndrome.

Author

Berardi, Giammauro, Cucchetti, Alessandro, Sposito, Carlo, Ratti, Francesca, Nebbia, Martina, DSouza, Daniel, Pascual, Franco, Dogeas, Epameinondas, Tohme, Samer, Vitale, Alessandro, DAmico, Francesco, Alessandris, Remo, Panetta, Valentina, Simonelli, Ilaria, Colasanti, Marco, Russolillo, Nadia, Moro, Amika, Fiorentini, Guido, Serenari, Matteo, Rotellar, Fernando, Zimitti, Giuseppe, Famularo, Simone, Ivanics, Tommy, Donando, Felipe, Hoffman, Daniel, Onkendi, Edwin, Essaji, Yasmin, Giuliani, Tommaso, Lopez Ben, Santiago, Caula, Celia, Rompianesi, Gianluca, Chopra, Asmita, Abu Hilal, Mohammed, Sapisochin, Gonzalo, Torzilli, Guido, Corvera, Carlos, Alseidi, Adnan, Helton, Scott, Troisi, Roberto, Simo, Kerri, Conrad, Claudius, Cescon, Matteo, Cleary, Sean, Kwon, David, Ferrero, Alessandro, Ettorre, Giuseppe, Cillo, Umberto, Geller, David, Cherqui, Daniel, Serrano, Pablo, Ferrone, Cristina, Aldrighetti, Luca, Kingham, T, and Mazzaferro, Vincenzo

Subjects
Hepatocellular carcinoma, Metabolic syndrome, Metabolic-associated fatty liver disease, Nonalcoholic fatty liver disease, Obesity, Recurrence, Steatosis
Abstract

BACKGROUND & AIMS: Metabolic syndrome (MS) is a growing epidemic and a risk factor for the development of hepatocellular carcinoma (HCC). This study investigated the long-term outcomes of liver resection (LR) for HCC in patients with MS. Rates, timing, patterns, and treatment of recurrences were investigated, and cancer-specific survivals were assessed. METHODS: Between 2001 and 2021, data from 24 clinical centers were collected. Overall survival (OS), recurrence-free survival (RFS), and cancer-specific survival were analyzed as well as recurrence patterns and treatment. The analysis was conducted using a competing-risk framework. The trajectory of the risk of recurrence over time was applied to a competing risk analysis. For post-recurrence survival, death resulting from tumor progression was the primary endpoint, whereas deaths with recurrence relating to other causes were considered as competing events. RESULTS: In total, 813 patients were included in the study. Median OS was 81.4 months (range 28.1-157.0 months), and recurrence occurred in 48.3% of patients, with a median RFS of 39.8 months (range 15.7-174.7 months). Cause-specific hazard of recurrence showed a first peak 6 months (0.027), and a second peak 24 months (0.021) after surgery. The later the recurrence, the higher the chance of receiving curative intent approaches (p = 0.001). Size >5 cm, multiple tumors, microvascular invasion, and cirrhosis were independent predictors of recurrence showing a cause-specific hazard over time. RFS was associated with death for recurrence (hazard ratio: 0.985, 95% CI: 0.977-0.995; p = 0.002). CONCLUSIONS: Patients with MS undergoing LR for HCC have good long-term survival. Recurrence occurs in 48% of patients with a double-peak incidence and time-specific hazards depending on tumor-related factors and underlying disease. The timing of recurrence significantly impacts survival. Surveillance after resection should be adjusted over time depending on risk factors. IMPACT AND IMPLICATIONS: Metabolic syndrome (MS) is a growing epidemic and a significant risk factor for the development of hepatocellular carcinoma (HCC). The present study demonstrated that patients who undergo surgical resection for HCC on MS have a good long-term survival and that recurrence occurs in almost half of the cases with a double peak incidence and time-specific hazards depending on tumor-related factors and underlying liver disease. Also, the timing of recurrence significantly impacts survival. Clinicians should therefore adjust follow-up after surgery accordingly, considering timing of recurrence and specific risk factors. Also, the results of the present study might help design future trials on the use of adjuvant therapy following resection.

Published
2024

3. Factors Associated with and Impact of Open Conversion in Laparoscopic and Robotic Minor Liver Resections: An International Multicenter Study of 10,541 Patients

Author

Saleh, Mansour, Pascual, Franco, Ghallab, Mohammed, Wu, Andrew G. R., Chin, Ken-Min, Ratti, Francesca, Giglio, Mariano Cesare, Garatti, Marco, Nghia, Phan Phuoc, Kato, Yutaro, Lim, Chetana, Herman, Paulo, Coelho, Fabricio Ferreira, Schmelzle, Moritz, Pratschke, Johann, Aghayan, Davit L., Liu, Qiu, Marino, Marco V., Belli, Andrea, Chiow, Adrian K. H., Sucandy, Iswanto, Ivanecz, Arpad, Di Benedetto, Fabrizio, Choi, Sung Hoon, Lee, Jae Hoon, Park, James O., Prieto, Mikel, Guzman, Yoelimar, Fondevila, Constantino, Efanov, Mikhail, Rotellar, Fernando, Choi, Gi-Hong, Robles-Campos, Ricardo, Kadam, Prashant, Sutcliffe, Robert P., Troisi, Roberto I., Tang, Chung Ngai, Chong, Charing C., D’Hondt, Mathieu, Dalla Valle, Bernardo, Ruzzenente, Andrea, Kingham, T. Peter, Scatton, Olivier, Liu, Rong, Mejia, Alejandro, Mishima, Kohei, Wakabayashi, Go, Lopez-Ben, Santiago, Wang, Xiaoying, Ferrero, Alessandro, Ettorre, Giuseppe Maria, Vivarelli, Marco, Mazzaferro, Vincenzo, Giuliante, Felice, Yong, Chee Chien, Yin, Mengqiu, Monden, Kazuteru, Geller, David, Chen, Kuo-Hsin, Sugioka, Atsushi, Edwin, Bjørn, Cheung, Tan-To, Long, Tran Cong Duy, Abu Hilal, Mohammad, Aldrighetti, Luca, Soubrane, Olivier, Fuks, David, Han, Ho-Seong, Cherqui, Daniel, and Goh, Brian K. P.

Published
2024
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4. Targeted inhibition of SCFSKP2 confers anti-tumor activities resulting in a survival benefit in osteosarcoma.

Author

Wang, Jichuan, Ferrena, Alexander, Zhang, Ranxin, Singh, Swapnil, Viscarret, Valentina, Al-Harden, Waleed, Aldahamsheh, Osama, Borjihan, Hasibagan, Singla, Amit, Yaguare, Simon, Tingling, Janet, Lo, Yungtai, Gorlick, Richard, Schwartz, Edward, Zhao, Hongling, Yang, Rui, Geller, David, Zheng, Deyou, Hoang, Bang, and Zi, Xiaolin

Subjects
Animals, Humans, Mice, Bone Neoplasms, Carcinogenesis, Cyclin-Dependent Kinase Inhibitor p27, Mice, Knockout, Osteosarcoma, S-Phase Kinase-Associated Proteins, Tumor Microenvironment
Abstract

Osteosarcoma(OS) is a highly aggressive bone cancer for which treatment has remained essentially unchanged for decades. Although OS is characterized by extensive genomic heterogeneity and instability, RB1 and TP53 have been shown to be the most commonly inactivated tumor suppressors in OS. We previously generated a mouse model with a double knockout (DKO) of Rb1 and Trp53 within cells of the osteoblastic lineage, which largely recapitulates human OS with nearly complete penetrance. SKP2 is a repression target of pRb and serves as a substrate recruiting subunit of the SCFSKP2 complex. In addition, SKP2 plays a central role in regulating the cell cycle by ubiquitinating and promoting the degradation of p27. We previously reported the DKOAA transgenic model, which harbored a knock-in mutation in p27 that impaired its binding to SKP2. Here, we generated a novel p53-Rb1-SKP2 triple-knockout model (TKO) to examine SKP2 function and its potential as a therapeutic target in OS. First, we observed that OS tumorigenesis was significantly delayed in TKO mice and their overall survival was markedly improved. In addition, the loss of SKP2 also promoted an apoptotic microenvironment and reduced the stemness of DKO tumors. Furthermore, we found that small-molecule inhibitors of SKP2 exhibited anti-tumor activities in vivo and in OS organoids as well as synergistic effects when combined with a standard chemotherapeutic agent. Taken together, our results suggest that SKP2 inhibitors may reduce the stemness plasticity of OS and should be leveraged as next-generation adjuvants in this cancer.

Published
2024

15. Detection of Alternative Lengthening of Telomeres via Chromogenic In Situ Hybridization for the Prognostication of PanNETs and Other Neoplasms

Author

Heaphy, Christopher M., Patel, Simmi, Smith, Katelyn, Wondisford, Anne R., Lynskey, Michelle L., O’Sullivan, Roderick J., Fuhrer, Kimberly, Han, Xiaoli, Seethala, Raja R., Liu, Ta-Chiang, Cao, Dengfeng, Ertunc, Onur, Zheng, Qizhi, Stojanova, Marija, Zureikat, Amer H., Paniccia, Alessandro, Lee, Kenneth, Ongchin, Melanie C., Pingpank, James F., Zeh, Herbert J., Hogg, Melissa E., Geller, David, Marsh, James Wallis, Brand, Randall E., Chennat, Jennifer S., Das, Rohit, Fasanella, Kenneth E., Gabbert, Charles, Khalid, Asif, McGrath, Kevin, Lennon, Anne Marie, Sarkaria, Savreet, Singh, Harkirat, Slivka, Adam, Hsu, Dennis, Zhang, Janie Y., Nacev, Benjamin A., Nikiforova, Marina N., Wald, Abigail I., Vaddi, Neel, De Marzo, Angelo M., Singhi, Anju H., Bell, Phoenix D., and Singhi, Aatur D.

Published
2025
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16. Matrix viscoelasticity promotes liver cancer progression in the pre-cirrhotic liver

Author

Fan, Weiguo, Adebowale, Kolade, Váncza, Lóránd, Li, Yuan, Rabbi, Md Foysal, Kunimoto, Koshi, Chen, Dongning, Mozes, Gergely, Chiu, David Kung-Chun, Li, Yisi, Tao, Junyan, Wei, Yi, Adeniji, Nia, Brunsing, Ryan L., Dhanasekaran, Renumathy, Singhi, Aatur, Geller, David, Lo, Su Hao, Hodgson, Louis, Engleman, Edgar G., Charville, Gregory W., Charu, Vivek, Monga, Satdarshan P., Kim, Taeyoon, Wells, Rebecca G., Chaudhuri, Ovijit, and Török, Natalie J.

Published
2024
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17. Impact of Liver Cirrhosis, Severity of Cirrhosis, and Portal Hypertension on the Difficulty and Outcomes of Laparoscopic and Robotic Major Liver Resections for Primary Liver Malignancies

Author

Cipriani, Federica, Aldrighetti, Luca, Ratti, Francesca, Wu, Andrew G. R., Kabir, Tousif, Scatton, Olivier, Lim, Chetana, Zhang, Wanguang, Sijberden, Jasper, Aghayan, Davit L., Siow, Tiing-Foong, Dokmak, Safi, Coelho, Fabricio Ferreira, Herman, Paulo, Marino, Marco V., Mazzaferro, Vincenzo, Chiow, Adrian K. H., Sucandy, Iswanto, Ivanecz, Arpad, Choi, Sung-Hoon, Lee, Jae Hoon, Gastaca, Mikel, Vivarelli, Marco, Giuliante, Felice, Ruzzenente, Andrea, Yong, Chee-Chien, Yin, Mengqiu, Fondevila, Constantino, Efanov, Mikhail, Morise, Zenichi, Di Benedetto, Fabrizio, Brustia, Raffaele, Dalla Valle, Raffaele, Boggi, Ugo, Geller, David, Belli, Andrea, Memeo, Riccardo, Gruttadauria, Salvatore, Mejia, Alejandro, Park, James O., Rotellar, Fernando, Choi, Gi-Hong, Robles-Campos, Ricardo, Wang, Xiaoying, Sutcliffe, Robert P., Pratschke, Johann, Lai, Eric C. H., Chong, Charing C. N., D’Hondt, Mathieu, Monden, Kazuteru, Lopez-Ben, Santiago, Kingham, T. Peter, Ferrero, Alessandro, Ettorre, Giuseppe Maria, Cherqui, Daniel, Liang, Xiao, Soubrane, Olivier, Wakabayashi, Go, Troisi, Roberto I., Cheung, Tan-To, Kato, Yutaro, Sugioka, Atsushi, Han, Ho-Seong, Long, Tran Cong duy, Liu, Qu, Liu, Rong, Edwin, Bjørn, Fuks, David, Chen, Kuo-Hsin, Abu Hilal, Mohammad, and Goh, Brian K. P.

Published
2024
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18. Circumstances and implications of conversion from minimally invasive to open liver resection: a multi-center analysis from the AMILES registry

Author

Gudmundsdottir, Hallbera, Fiorentini, Guido, Essaji, Yasmin, D’Souza, Daniel, Torres-Ruiz, Tania, Geller, David A., Helton, W. Scott, Hogg, Melissa E., Iannitti, David A., Kamath, Ashwin S., Onkendi, Edwin O., Serrano, Pablo E., Simo, Kerri A., Sucandy, Iswanto, Warner, Susanne G., Alseidi, Adnan, and Cleary, Sean P.

Published
2023
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19. Defining Global Benchmarks for Laparoscopic Right Posterior Sectionectomy/H67: An International Multicenter Study

Author

Zhao, Jianping, Lu, Yuanxiang, Zhang, Wanguang, Chua, Darren W., Liu, Qu, Liu, Rong, Pratschke, Johann, Ratti, Francesca, Zimmitti, Giuseppe, Aghayan, Davit L., Edwin, Bjørn, Siow, Tiing-Foong, Scatton, Olivier, Herman, Paulo, Marino, Marco V., Mazzaferro, Vincenzo, Chiow, Adrian K. H., Sucandy, Iswanto, Ivanecz, Arpad, Choi, Sung Hoon, Lee, Jae Hoon, Gastaca, Mikel, Vivarelli, Marco, Giuliante, Felice, Ruzzenente, Andrea, Yong, Chee-Chien, Yin, Mengqiu, Fondevila, Constantino, Efanov, Mikhail, Morise, Zenichi, Di Benedetto, Fabrizio, Brustia, Raffaele, Dalla Valle, Raffaele, Boggi, Ugo, Geller, David, Belli, Andrea, Memeo, Riccardo, Mejia, Alejandro, Park, James O., Rotellar, Fernando, Choi, Gi-Hong, Robles-Campos, Ricardo, Wang, Xiaoying, Sutcliffe, Robert P., Lai, Eric C. H., Chong, Charing C. N., D’Hondt, Mathieu, Monden, Kazuteru, Lopez-Ben, Santiago, Kingham, T. Peter, Ferrero, Alessandro, Ettorre, Giuseppe Maria, Cherqui, Daniel, Liang, Xiao, Soubrane, Olivier, Fuks, David, Wakabayashi, Go, Troisi, Roberto I., Cheung, Tan-To, Sugioka, Atsushi, Long, Tran Cong duy, Abu Hilal, Mohammad, Aldrighetti, Luca, Chen, Kuo-Hsin, Han, Ho-Seong, Goh, Brian K. P., Prieto, Mikel, De Meyere, Celine, Meurs, Juul, Ng, Kelvin K., Lee, Kit-Fai, Tarakanov, Pavel, Alikhanov, Ruslan, Thiruchelvam, Nita, Jang, Jae Young, Kojima, Masayuki, Kato, Yutaro, Kruger, Jaime Arthur Pirola, Coelho, Fabricio Ferreira, Lopez-Lopez, Victor, Casellas I Robert, Margarida, Montalti, Roberto, Giglio, Mariano, Lee, Boram, Wang, Hao-Ping, Salleh, Mansour, Pascual, Franco, Yu, Shian, Chen, Zewei, Vani, Simone, Ardito, Francesco, Giustizieri, Ugo, Citterio, Davide, Mocchegiani, Federico, Colasanti, Marco, Berardi, Giammauro, Guzmán, Yoelimar, Labadie, Kevin P., Conticchio, Maria, Dogeas, Epameinondas, Kauffmann, Emanuele F., Giuffrida, Mario, Sommacale, Daniele, Amory, Boris, Magistri, Paolo, Mishima, Kohei, Kadam, Prashant, Tang, Chung-Ngai, Ghotbi, Jacob, Fretland, Åsmund Avdem, Forchino, Fabio, Mazzotta, Alessandro, Barbara, Marco, Pagano, Duilio, Gruttadauria, Salvatore, Krenzien, Felix, Schmelzle, Moritz, Cipriani, Federica, Lim, Chetana, Zheng, Junhao, Nghia, Phan Phuoc, Valle, Bernardo Dalla, and Cipriani, Federica

Published
2024
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21. Impact of neoadjuvant chemotherapy on short-term outcomes after simple and complex minimally invasive minor hepatectomy for colorectal liver metastases: A propensity-score matched and coarsened exact matched study

Author

Syn, Nicholas L., Prieto, Mikel, Meurs, Juul, De Meyere, Celine, Lee, Kit-Fai, Ng, Kelvin K., Salimgereeva, Diana, Alikhanov, Ruslan, Thiruchelvam, Nita, Jang, Jae Young, Kato, Yutaro, Kojima, Masayuki, Coelho, Fabricio Ferreira, Pirola Kruger, Jaime Arthur, Lopez-Lopez, Victor, Casellas I Robert, Margarida, Montalti, Roberto, Giglio, Mariano, Lee, Boram, D'Silva, Mizelle, Wang, Hao-Ping, Saleh, Mansour, Pascual, Franco, Chen, Zewei, Yu, Shian, Vani, Simone, Ardito, Francesco, Giustizieri, Ugo, Citterio, Davide, Mocchegiani, Federico, Colasanti, Marco, Berardi, Giammauro, Guzmán, Yoelimar, Labadie, Kevin P., Conticchio, Maria, Dogeas, Epameinondas, Kauffmann, Emanuele F., Giuffrida, Mario, Sommacale, Daniele, Laurent, Alexis, Magistri, Paolo, Nghia, Phan Phuoc, Mishima, Kohei, Valle, Bernardo Dalla, Krenzien, Felix, Schmelzle, Moritz, Kadam, Prashant, Liu, Qu, Lai, Eric C.H., Zheng, Junhao, Siow, Tiing Foong, Forchino, Fabio, Ghotbi, Jacob, Fretland, Åsmund A., Lim, Chetana, Mazzotta, Alessandro, Cauchy, Francois, Karam, Elias, Barbara, Marco, Pagano, Duilio, Ratti, Francesca, Hoogteijling, Tijs J., Abu Hilal, Mohammad, Zimmitti, Giuseppe, Aghayan, Davit L., Wu, Andrew G.R., Cipriani, Federica, Gruttadauria, Salvatore, Scatton, Olivier, Long, Tran Cong duy, Herman, Paulo, Marino, Marco V., Mazzaferro, Vincenzo, Chiow, Adrian K.H., Sucandy, Iswanto, Ivanecz, Arpad, Choi, Sung Hoon, Lee, Jae Hoon, Gastaca, Mikel, Vivarelli, Marco, Giuliante, Felice, Ruzzenente, Andrea, Yong, Chee Chien, Yin, Mengqiu, Fondevila, Constantino, Efanov, Mikhail, Morise, Zenichi, Di Benedetto, Fabrizio, Brustia, Raffaele, Dalla Valle, Raffaele, Boggi, Ugo, Geller, David, Belli, Andrea, Memeo, Riccardo, Mejia, Alejandro, Park, James O., Rotellar, Fernando, Choi, Gi Hong, Robles-Campos, Ricardo, Wang, Xiaoying, Sutcliffe, Robert P., Pratschke, Johann, Tang, Chung-Ngai, Chong, Charing C.N., D'Hondt, Mathieu, Monden, Kazuteru, Lopez-Ben, Santiago, Kingham, T. Peter, Ferrero, Alessandro, Ettorre, Giuseppe Maria, Cherqui, Daniel, Liang, Xiao, Soubrane, Olivier, Wakabayashi, Go, Troisi, Roberto I., Han, Ho Seong, Cheung, Tan To, Sugioka, Atsushi, Dokmak, Safi, Chen, Kuo Hsin, Liu, Rong, Fuks, David, Zhang, Wanguang, Aldrighetti, Luca, Edwin, Bjørn, and Goh, Brian K.P.

Published
2024
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22. Robotic Versus Laparoscopic Liver Resection in Various Settings: An International Multicenter Propensity Score Matched Study of 10.075 Patients

Author

Sijberden, Jasper P., Hoogteijling, Tijs J., Aghayan, Davit, Ratti, Francesca, Tan, Ek-Khoon, Morrison-Jones, Victoria, Lanari, Jacopo, Haentjens, Louis, Wei, Kongyuan, Tzedakis, Stylianos, Martinie, John, Osei Bordom, Daniel, Zimmitti, Giuseppe, Crespo, Kaitlyn, Magistri, Paolo, Russolillo, Nadia, Conci, Simone, Görgec, Burak, Benedetti Cacciaguerra, Andrea, D’Souza, Daniel, Zozaya, Gabriel, Caula, Cèlia, Geller, David, Robles Campos, Ricardo, Croner, Roland, Rehman, Shafiq, Jovine, Elio, Efanov, Mikhail, Alseidi, Adnan, Memeo, Riccardo, Dagher, Ibrahim, Giuliante, Felice, Sparrelid, Ernesto, Ahmad, Jawad, Gallagher, Tom, Schmelzle, Moritz, Swijnenburg, Rutger-Jan, Fretland, Åsmund Avdem, Cipriani, Federica, Koh, Ye-Xin, White, Steven, Lopez Ben, Santi, Rotellar, Fernando, Serrano, Pablo E., Vivarelli, Marco, Ruzzenente, Andrea, Ferrero, Alessandro, Di Benedetto, Fabrizio, Besselink, Marc G., Sucandy, Iswanto, Sutcliffe, Robert P., Vrochides, Dionisios, Fuks, David, Liu, Rong, D’Hondt, Mathieu, Cillo, Umberto, Primrose, John N., Goh, Brian K.P., Aldrighetti, Luca A., Edwin, Bjørn, and Abu Hilal, Mohammad

Published
2024
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23. Patient, family caregiver, and economic outcomes of an integrated screening and novel stepped collaborative care intervention in the oncology setting in the USA (CARES): a randomised, parallel, phase 3 trial

Author

Steel, Jennifer L, George, Charles J, Terhorst, Lauren, Yabes, Jonathan G, Reyes, Vincent, Zandberg, Dan P, Nilsen, Marci, Kiefer, Gauri, Johnson, Jonas, Marsh, Christopher, Bierenbaum, Jason, Tageja, Nishant, Krauze, Michal, VanderWeele, Robert, Goel, Gaurav, Ramineni, Gopala, Antoni, Michael, Vodovotz, Yoram, Walker, Jon, Tohme, Samer, Billiar, Timothy, and Geller, David A

Published
2024
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28. Nuclear factor erythroid 2–related factor 2 and β‐Catenin Coactivation in Hepatocellular Cancer: Biological and Therapeutic Implications

Author

Tao, Junyan, Krutsenko, Yekaterina, Moghe, Akshata, Singh, Sucha, Poddar, Minakshi, Bell, Aaron, Oertel, Michael, Singhi, Aatur D, Geller, David, Chen, Xin, Lujambio, Amaia, Liu, Silvia, and Monga, Satdarshan P

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Liver Disease, Rare Diseases, Digestive Diseases, Genetics, Cancer, Liver Cancer, Adolescent, Aged, Aged, 80 and over, Animals, Carcinogenesis, Carcinoma, Hepatocellular, Datasets as Topic, Disease Models, Animal, Female, Gene Expression Regulation, Neoplastic, Humans, Liver, Liver Neoplasms, Male, Mice, Middle Aged, Mutation, NF-E2-Related Factor 2, Signal Transduction, Tumor Burden, beta Catenin, Medical Biochemistry and Metabolomics, Clinical Sciences, Immunology, Gastroenterology & Hepatology, Clinical sciences
Abstract

Background and aimsHCC remains a major unmet clinical need. Although activating catenin beta-1 (CTNNB1) mutations are observed in prominent subsets of HCC cases, these by themselves are insufficient for hepatocarcinogenesis. Coexpression of mutant CTNNB1 with clinically relevant co-occurrence has yielded HCCs. Here, we identify cooperation between β-catenin and nuclear factor erythroid 2-related factor 2 (Nrf2) signaling in HCC.Approach and resultsPublic HCC data sets were assessed for concomitant presence of CTNNB1 mutations and either mutations in nuclear factor erythroid-2-related factor-2 (NFE2L2) or Kelch like-ECH-associated protein 1 (KEAP1), or Nrf2 activation by gene signature. HCC development in mice and similarity to human HCC subsets was assessed following coexpression of T41A-CTNNB1 with either wild-type (WT)-, G31A-, or T80K-NFE2L2. Based on mammalian target of rapamycin complex 1 activation in CTNNB1-mutated HCCs, response of preclinical HCC to mammalian target of rapamycin (mTOR) inhibitor was investigated. Overall, 9% of HCC cases showed concomitant CTNNB1 mutations and Nrf2 activation, subsets of which were attributable to mutations in NFE2L2/KEAP1. Coexpression of mutated CTNNB1 with mutant NFE2L2, but not WT-NFE2L2, led to HCC development and mortality by 12-14 weeks. These HCCs were positive for β-catenin targets, like glutamine synthetase and cyclin-D1, and Nrf2 targets, like NAD(P)H quinone dehydrogenase 1 and peroxiredoxin 1. RNA-sequencing and pathway analysis showed high concordance of preclinical HCC to human HCC subset showing activation of unique (iron homeostasis and glioblastoma multiforme signaling) and expected (glutamine metabolism) pathways. NFE2L2-CTNNB1 HCC mice were treated with mTOR inhibitor everolimus (5-mg/kg diet ad libitum), which led to >50% decrease in tumor burden.ConclusionsCoactivation of β-catenin and Nrf2 is evident in 9% of all human HCCs. Coexpression of mutant NFE2L2 and mutant CTNNB1 led to clinically relevant HCC development in mice, which responded to mTOR inhibitors. Thus, this model has both biological and therapeutic implications.

Published
2021

30. The interaction of SKP2 with p27 enhances the progression and stemness of osteosarcoma

Author

Wang, Jichuan, Aldahamsheh, Osama, Ferrena, Alexander, Borjihan, Hasibagan, Singla, Amit, Yaguare, Simon, Singh, Swapnil, Viscarret, Valentina, Tingling, Janet, Zi, Xiaolin, Lo, Yungtai, Gorlick, Richard, Zheng, Deyou, Schwartz, Edward L, Zhao, Hongling, Yang, Rui, Geller, David S, and Hoang, Bang H

Subjects
Rare Diseases, Cancer, 2.1 Biological and endogenous factors, Aetiology, Animals, Carcinogenesis, Cells, Cultured, Cyclin-Dependent Kinase Inhibitor p27, Gene Expression Regulation, Neoplastic, Humans, Mice, Mice, Inbred C57BL, Mice, Knockout, Osteosarcoma, Proto-Oncogene Mas, Retinoblastoma Binding Proteins, S-Phase Kinase-Associated Proteins, Tumor Suppressor Protein p53, p27, phosphorylation, accumulation, SCFSKP2 inhibitors, transgenic mouse, osteosarcoma, General Science & Technology
Abstract

Osteosarcoma is a highly aggressive malignancy for which treatment has remained essentially unchanged for years. Our previous studies found that the F-box protein SKP2 is overexpressed in osteosarcoma, acting as a proto-oncogene; p27Kip1 (p27) is an inhibitor of cyclin-dependent kinases and a downstream substrate of SKP2-mediated ubiquitination. Overexpression of SKP2 and underexpression of p27 are common characteristics of cancer cells. The SCFSKP2 E3 ligase ubiquitinates Thr187-phosphorylated p27 for proteasome degradation, which can be abolished by a Thr187Ala knock-in (p27T187A KI) mutation. RB1 and TP53 are two major tumor suppressors commonly coinactivated in osteosarcoma. We generated a mouse model with a double knockout (DKO) of Rb1 and Trp53 within cells of the osteoblastic lineage, which developed osteosarcoma with full penetrance. When p27T187A KI mice were crossed on to the DKO background, p27T187A protein was found to accumulate in osteosarcoma tumor tissues. Furthermore, p27T187A promoted apoptosis in DKO tumors, slowed disease progression, and significantly prolonged overall survival. RNA sequencing analysis also linked the SCFSKP2 -p27T187A axis to potentially reduced cancer stemness. Given that RB1 and TP53 loss or coinactivation is common in human osteosarcoma, our study suggests that inhibiting the SKP2-p27 axis may represent a desirable therapeutic strategy for this cancer.

Published
2021

33. Impact of liver cirrhosis, the severity of cirrhosis, and portal hypertension on the outcomes of minimally invasive left lateral sectionectomies for primary liver malignancies

Author

Syn, Nicholas L., Prieto, Mikel, Meurs, Juul, De Meyere, Celine, Lee, Kit-Fai, Salimgereeva, Diana, Alikhanov, Ruslan, Kato, Yutaro, Kojima, Masayuki, Robert, Margarida Casellas I., Lee, Boram, D’Silva, Mizelle, Saleh, Mansour, Pascual, Franco, Ardito, Francesco, Citterio, Davide, Mocchegiani, Federico, Berardi, Giammauro, Colasanti, Marco, Guzmán, Yoelimar, Labadie, Kevin P., Conticchio, Maria, Dogeas, Epameinondas, Kauffmann, Emanuele F., Giuffrida, Mario, Laurent, Alexis, Magistri, Paolo, Mishima, Kohei, Schmelzle, Moritz, Krenzien, Felix, Kadam, Prashant, Lai, Eric C., Ghotbi, Jacob, Fretland, Åsmund Avdem, Forchino, Fabio, Mazzotta, Alessandro, Cauchy, Francois, Kawaguchi, Yoshikuni, Lim, Chetana, Valle, Bernardo Dalla, Liu, Qu, Zheng, Junhao, Nghia, Phan Phuoc, Chen, Zewei, Yu, Shian, Coelho, Fabricio Ferreira, Herman, Paulo, Kruger, Jaime A.P., Wu, Andrew G.R., Chin, Ken-Min, Hasegawa, Kiyoshi, Zhang, Wanguang, Alzoubi, Mohammad, Aghayan, Davit L., Siow, Tiing-Foong, Scatton, Olivier, Kingham, T. Peter, Marino, Marco V., Mazzaferro, Vincenzo, Chiow, Adrian K.H., Sucandy, Iswanto, Ivanecz, Arpad, Choi, Sung Hoon, Lee, Jae Hoon, Gastaca, Mikel, Vivarelli, Marco, Giuliante, Felice, Ruzzenente, Andrea, Yong, Chee-Chien, Dokmak, Safi, Fondevila, Constantino, Efanov, Mikhail, Morise, Zenichi, Di Benedetto, Fabrizio, Brustia, Raffaele, Valle, Raffaele Dalla, Boggi, Ugo, Geller, David, Belli, Andrea, Memeo, Riccardo, Gruttadauria, Salvatore, Mejia, Alejandro, Park, James O., Rotellar, Fernando, Choi, Gi Hong, Robles-Campos, Ricardo, Wang, Xiaoying, Sutcliffe, Robert P., Pratschke, Johann, Lai, Eric C.H., Chong, Charing C.N., D’Hondt, Mathieu, Monden, Kazuteru, Lopez-Ben, Santiago, Liu, Rong, Ferrero, Alessandro, Ettorre, Giuseppe Maria, Cipriani, Federica, Cherqui, Daniel, Liang, Xiao, Soubrane, Olivier, Wakabayashi, Go, Troisi, Roberto I., Yin, Mengqiu, Cheung, Tan-To, Sugioka, Atsushi, Han, Ho-Seong, Long, Tran Cong Duy, Fuks, David, Abu Hilal, Mohammad, Chen, Kuo-Hsin, Aldrighetti, Luca, Edwin, Bjørn, and Goh, Brian K.P.

Published
2023
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34. Skp2 Depletion Reduces Tumor-Initiating Properties and Promotes Apoptosis in Synovial Sarcoma

Author

Wang, Jichuan, Sato, Kenji, O'Donnell, Ed, Singla, Amit, Yaguare, Simon, Aldahamsheh, Osama, Batko, Brian, Borjihan, Hasibagan, Tingling, Janet, Zhang, Jinghang, Weiser, Daniel A, Loeb, David M, Gorlick, Richard, Schwartz, Edward L, Yang, Rui, Zi, Xiaolin, Zhao, Hongling, Geller, David S, and Hoang, Bang H

Subjects
Biochemistry and Cell Biology, Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Biological Sciences, Cancer, Stem Cell Research - Nonembryonic - Human, Stem Cell Research, 5.1 Pharmaceuticals, Aetiology, 2.1 Biological and endogenous factors, Development of treatments and therapeutic interventions, Clinical Sciences, Oncology & Carcinogenesis, Biochemistry and cell biology, Oncology and carcinogenesis
Abstract

Synovial sarcoma (SS) is an aggressive soft-tissue cancer with a poor prognosis and a propensity for local recurrence and distant metastasis. In this study, we investigated whether S phase kinase-associated protein (Skp2) plays an oncogenic role in tumor initiation, progression, and metastasis of SS. Our study revealed that Skp2 is frequently overexpressed in SS specimens and SS18-SSX transgenic mouse tumors, as well as correlated with clinical stages. Next, we identified that genetic depletion of Skp2 reduced mesenchymal and stemness markers, and inhibited the invasive and proliferative capacities of SS cell lines. Furthermore, Skp2 depletion markedly suppressed the growth of SS xenografts tumors. Treatment of SS cell lines with the skp2 inhibitor flavokawain A (FKA) reduced Skp2 expression in a dose-dependent manner and resulted in cell cycle arrest and apoptosis. FKA also suppressed the invasion and tumor-initiating properties in SS, similar to the effects of Skp2 knockdown. In addition, a combination of FKA and conventional chemotherapy showed a synergistic therapeutic efficacy. Taken together, our results suggest that Skp2 plays an essential role in the biology of SS by promoting the mesenchymal state and cancer stemness. Given that chemotherapy resistance is often associated with cancer stemness, strategies of combining Skp2 inhibitors with conventional chemotherapy in SS may be desirable.

Published
2020

35. Adverse childhood experiences (ACEs), cell-mediated immunity, and survival in the context of cancer

Author

Steel, Jennifer L, Antoni, Michael, Pathak, Ritambhara, Butterfield, Lisa H, Vodovotz, Yoram, Savkova, Alexandra, Wallis, Marsh, Wang, Yisi, Jing, Hui, Grammer, Elizabeth, Burke, Robin, Brady, Mya, and Geller, David A

Subjects
Biomedical and Clinical Sciences, Immunology, Mental Health, Cancer, Patient Safety, 2.1 Biological and endogenous factors, Inflammatory and immune system, Good Health and Well Being, Adverse Childhood Experiences, Child, Female, Humans, Immunity, Cellular, Male, Neoplasms, Parents, Surveys and Questionnaires, Adverse childhood experiences, Trauma, Immunity, Neurosciences, Psychology, Neurology & Neurosurgery, Biological psychology
Abstract

PurposeAdverse childhood experiences (ACEs) have been shown to be associated with increased risk of mortality. The biobehavioral mechanisms linking adverse events and survival in cancer patients remain unclear. The aims of the study were to: (1) examine the rates and types of early adverse events in patients diagnosed with cancer; (2) investigate the association of adverse events with circulating cytokines, representing immune status of the patient; and (3) test whether immune markers mediated the association between early adverse events and survival while adjusting for other factors that are associated with immunity (e.g., fatigue) and survival (e.g., depression).Patients and methodsThe patients were recruited from an outpatient oncology clinic. Patients were administered a battery of questionnaires including the Traumatic Events Survey and the Center for Epidemiological Studies-Depression scale. Blood was collected and serum levels of cytokines were assessed to characterize immune status. Descriptive statistics, Mann-Whitney U tests and Cox regression were performed to address study aims.ResultsOf the 408 patients, 66% reported at least one ACE. After adjusting for demographic, disease-specific factors, and psychological/behavioral factors; having had a major upheaval between parents during childhood or adolescence was associated with poorer survival [β = -0.702, HR = 0.496, p = 0.034]. Lower levels of interleukin-2 (IL-2) explained, in part, the link between this early adverse event and poorer survival as when IL-2 was entered into the model, a major upheaval between one's parents and survival was no longer significant [β = -0.612, HR = 0.542, p = 0.104].ConclusionHaving experienced an ACE was associated with lower IL-2 levels-a growth factor for anti-inflammatory T-regulatory lymphocytes-central in contemporary immunotherapy, as well as poorer survival in those diagnosed with cancer. Since lower IL-2 levels also explained, in part, the link between the ACE involving parental upheaval and survival, there is support for a psychoneuroimmunological model of disease course in this vulnerable population.

Published
2020

36. Impact of body mass index on perioperative outcomes of laparoscopic major hepatectomies

Author

Prieto, Mikel, De Meyere, Celine, Lee, Kit-Fai, Ng, Kelvin K., Salimgereeva, Diana, Alikhanov, Ruslan, Lee, Lip-Seng, Jang, Jae Young, Kojima, Masayuki, Kruger, Jaime Arthur Pirola, Lopez-Lopez, Victor, Robert, Margarida Casellas I., Montalti, Roberto, Giglio, Mariano, Lee, Boram, Wang, Hao-Ping, Saleh, Mansour, Yu, Shian, Vani, Simone, Ardito, Francesco, Giustizieri, Ugo, Citterio, Davide, Mocchegiani, Federico, Colasanti, Marco, Guzmán, Yoelimar, Labadie, Kevin P., Conticchio, Maria, Dogeas, Epameinondas, Kauffmann, Emanuele F., Giuffrida, Mario, Sommacale, Daniele, Laurent, Alexis, Magistri, Paolo, Mishima, Kohei, Krenzien, Felix, Kadam, Prashant, Lai, Eric C.H., Ghotbi, Jacob, Fretland, Åsmund Avdem, Forchino, Fabio, Mazzotta, Alessandro, Berardi, Giammauro, Kingham, T. Peter, Zhang, Wanguang, Syn, Nicholas L., Koh, Ye-Xin, Jaber, Bashar, Aghayan, Davit L., Siow, Tiing Foong, Lim, Chetana, Scatton, Olivier, Herman, Paulo, Coelho, Fabricio Ferreira, Marino, Marco V., Mazzaferro, Vincenzo, Chiow, Adrian K.H., Sucandy, Iswanto, Ivanecz, Arpad, Choi, Sung Hoon, Lee, Jae Hoon, Gastaca, Mikel, Vivarelli, Marco, Giuliante, Felice, Dalla Valle, Bernardo, Ruzzenente, Andrea, Yong, Chee-Chien, Chen, Zewei, Yin, Mengqiu, Fondevila, Constantino, Efanov, Mikhail, Morise, Zenichi, Di Benedetto, Fabrizio, Brustia, Raffaele, Dalla Valle, Raffaele, Boggi, Ugo, Geller, David, Belli, Andrea, Memeo, Riccardo, Gruttadauria, Salvatore, Mejia, Alejandro, Park, James O., Rotellar, Fernando, Choi, Gi-Hong, Robles-Campos, Ricardo, Wang, Xiaoying, Sutcliffe, Robert P., Schmelzle, Moritz, Pratschke, Johann, Chong, Charing C.N., Meurs, Juul, D’Hondt, Mathieu, Monden, Kazuteru, Lopez-Ben, Santiago, Liu, Qu, Liu, Rong, Ferrero, Alessandro, Ettorre, Giuseppe Maria, Cipriani, Federica, Pascual, Franco, Cherqui, Daniel, Zheng, Junhao, Liang, Xiao, Soubrane, Olivier, Wakabayashi, Go, Troisi, Roberto I., Cheung, Tan-To, Kato, Yutaro, Sugioka, Atsushi, D’Silva, Mizelle, Han, Ho-Seong, Nghia, Phan Phuoc, Long, Tran Cong duy, Edwin, Bjørn, Fuks, David, Abu Hilal, Mohammad, Aldrighetti, Luca, Chen, Kuo-Hsin, and Goh, Brian K.P.

Published
2023
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39. Propensity Score-Matching Analysis Comparing Robotic Versus Laparoscopic Limited Liver Resections of the Posterosuperior Segments: An International Multicenter Study

Author

Krenzien, Felix, Schmelzle, Moritz, Pratschke, Johann, Feldbrügge, Linda, Liu, Rong, Liu, Qu, Zhang, Wanguang, Zhao, Joseph J., Tan, Hwee-Leong, Cipriani, Federica, Hoogteijling, Tijs J., Aghayan, Davit L., Fretland, Åsmund A., Siow, Tiing Foong, Lim, Chetana, Scatton, Olivier, Herman, Paulo, Coelho, Fabricio F., Marino, Marco V., Mazzaferro, Vincenzo, Chiow, Adrian K.H., Sucandy, Iswanto, Ivanecz, Arpad, Choi, Sung Hoon, Lee, Jae Hoon, Gastaca, Mikel, Vivarelli, Marco, Giuliante, Felice, Dalla Valle, Bernardo, Ruzzenente, Andrea, Yong, Chee-Chien, Chen, Zewei, Yin, Mengqiu, Fondevila, Constantino, Efanov, Mikhail, Morise, Zenichi, Di Benedetto, Fabrizio, Brustia, Raffaele, Dalla Valle, Raffaele, Boggi, Ugo, Geller, David, Belli, Andrea, Memeo, Riccardo, Gruttadauria, Salvatore, Mejia, Alejandro, Park, James O., Rotellar, Fernando, Choi, Gi-Hong, Robles-Campos, Ricardo, Wang, Xiaoying, Sutcliffe, Robert P., Hasegawa, Kiyoshi, Tang, Chung-Ngai, Chong, Charing C. N., Lee, Kit-Fai, Meurs, Juul, D’Hondt, Mathieu, Monden, Kazuteru, Lopez-Ben, Santiago, Kingham, T. Peter, Ferrero, Alessandro, Ettorre, Giuseppe M., Pascual, Franco, Cherqui, Daniel, Zheng, Junhao, Liang, Xiao, Soubrane, Olivier, Wakabayashi, Go, Troisi, Roberto I., Cheung, Tan-To, Kato, Yutaro, Sugioka, Atsushi, Dokmak, Safi, D’Silva, Mizelle, Han, Ho-Seong, Nghia, Phan Phuoc, Long, Tran Cong duy, Hilal, Mohammad Abu, Chen, Kuo-Hsin, Fuks, David, Aldrighetti, Luca, Edwin, Bjørn, Goh, Brian K. P., Syn, Nicholas L., Prieto, Mikel, De Meyere, Celine, Ng, Kelvin K., Salimgereeva, Diana, Alikhanov, Ruslan, Thiruchelvam, Nita, Jang, Jae Young, Kojima, Masayuki, Kruger, Jaime Arthur Pirola, Lopez-Lopez, Victor, Robert, Margarida Casellas I, Montalti, Roberto, Giglio, Mariano, Lee, Boram, Wang, Hao-Ping, Salleh, Mansour, Yu, Shian, Vani, Simone, Ardito, Francesco, Giustizieri, Ugo, Citterio, Davide, Mocchegiani, Federico, Colasanti, Marco, Berardi, Giammauro, Guzmán, Yoelimar, Labadie, Kevin P., Conticchio, Maria, Dogeas, Epameinondas, Kauffmann, Emanuele F., Giuffrida, Mario, Sommacale, Daniele, Amory, Boris, Magistri, Paolo, Mishima, Kohei, Kadam, Prashant, Lai, Eric C. H., Ghotbi, Jacob, Forchino, Fabio, Mazzotta, Alessandro, Kawaguchi, Yoshikuni, Cauchy, Francois, Karam, Elias, Barbara, Marco, and Pagano, Duilio

Published
2024
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40. Propensity-score Matched and Coarsened-exact Matched Analysis Comparing Robotic and Laparoscopic Major Hepatectomies: An International Multicenter Study of 4822 Cases

Author

Liu, Qu, Zhang, Wanguang, Zhao, Joseph J., Syn, Nicholas L., Cipriani, Federica, Alzoubi, Mohammad, Aghayan, Davit L., Siow, Tiing-Foong, Lim, Chetana, Scatton, Olivier, Herman, Paulo, Coelho, Fabricio Ferreira, Marino, Marco V., Mazzaferro, Vincenzo, Chiow, Adrian K. H., Sucandy, Iswanto, Ivanecz, Arpad, Choi, Sung-Hoon, Lee, Jae Hoon, Prieto, Mikel, Vivarelli, Marco, Giuliante, Felice, Dalla Valle, Bernardo, Ruzzenente, Andrea, Yong, Chee-Chien, Chen, Zewei, Yin, Mengqiu, Fondevila, Constantino, Efanov, Mikhail, Morise, Zenichi, Di Benedetto, Fabrizio, Brustia, Raffaele, Dalla Valle, Raffaele, Boggi, Ugo, Geller, David, Belli, Andrea, Memeo, Riccardo, Gruttadauria, Salvatore, Mejia, Alejandro, Park, James O., Rotellar, Fernando, Choi, Gi-Hong, Robles-Campos, Ricardo, Wang, Xiaoying, Sutcliffe, Robert P., Schmelzle, Moritz, Pratschke, Johann, Tang, Chung-Ngai, Chong, Charing C. N., Lee, Kit-Fai, Meurs, Juul, D’Hondt, Mathieu, Monden, Kazuteru, Lopez-Ben, Santiago, Kingham, Thomas Peter, Ferrero, Alessandro, Ettorre, Giuseppe Maria, Levi Sandri, Giovanni Battista, Saleh, Mansour, Cherqui, Daniel, Zheng, Junhao, Liang, Xiao, Mazzotta, Alessandro, Soubrane, Olivier, Wakabayashi, Go, Troisi, Roberto I., Cheung, Tan-To, Kato, Yutaro, Sugioka, Atsushi, D’Silva, Mizelle, Han, Ho-Seong, Nghia, Phan Phuoc, Long, Tran Cong duy, Edwin, Bjørn, Fuks, David, Chen, Kuo-Hsin, Abu Hilal, Mohammad, Aldrighetti, Luca, Liu, Rong, Goh, Brian K. P., Gastaca, Mikel, De Meyere, Celine, Ng, Kelvin K., Salimgereeva, Diana, Alikhanov, Ruslan, Lee, Lip-Seng, Jang, Jae Young, Kojima, Masayuki, Kruger, Jaime Arthur Pirola, Lopez-Lopez, Victor, Casellas I Robert, Margarida, Roberto, Montalti, Giglio, Mariano, Lee, Boram, Wang, Hao-Ping, Pascual, Franco, Yu, Shian, Vani, Simone, Ardito, Francesco, Giustizieri, Ugo, Citterio, Davide, Mocchegiani, Federico, Colasanti, Marco, Guzmán, Yoelimar, Labadie, Kevin P., Conticchio, Maria, Dogeas, Epameinondas, Kauffmann, Emanuele F., Giuffrida, Mario, Sommacale, Daniele, Laurent, Alexis, Magistri, Paolo, Mishima, Kohei, Krenzien, Felix, Kadam, Prashant, Lai, Eric C. H., Ghotbi, Jacob, Fretland, Åsmund Avdem, and Forchino, Fabio

Published
2023
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43. Contributors

Author

Ashraf, Ambika P., primary, Assadi, Farahnak, additional, Barber, Thomas M., additional, Ceccato, Filippo, additional, Fernandes, Stuti, additional, Fernandesz, Cornelius J., additional, Fleseriu, Maria, additional, Gama, Rousseau, additional, Geller, David S., additional, Goemann, Iuri Martin, additional, Grassi, Guido, additional, Guran, Tulay, additional, Hanna, Fahmy W.F., additional, Hooman, Nakysa, additional, Jansen, Pieter, additional, Jebasingh, Felix, additional, Korbonits, Márta, additional, Maia, Ana Luiza, additional, Mantero, Franco, additional, Mazaheri, Mojgan, additional, Mihai, Gabriela, additional, Nazari, Matthew A., additional, Oduro-Donkor, Dominic, additional, Ordidge, Katherine, additional, Pacak, Karel, additional, Pappachan, Joseph M., additional, Petrák, Ondřej, additional, Ragnarsson, Oskar, additional, Sahdev, Anju, additional, Sanders, Anna, additional, Scholl, Ute I., additional, Seravalle, Gino, additional, Sharbaf, Fatemeh Ghane, additional, Stowasser, Michael, additional, Stratakis, Constantine A., additional, Szwarcbard, Naomi, additional, Thomas, Nihal, additional, Tizianel, Irene, additional, Topliss, Duncan J., additional, Tosun, Busra Gurpinar, additional, Valaiyapathi, Badhma, additional, Varlamov, Elena V., additional, Voltan, Giacomo, additional, Wolley, Martin, additional, and Zelinka, Tomáš, additional

Published
2023
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45. Minimally Invasive Versus Open Liver Resections for Hepatocellular Carcinoma in Patients With Metabolic Syndrome

Author

Berardi, Giammauro, Ivanics, Tommy, Sapisochin, Gonzalo, Ratti, Francesca, Sposito, Carlo, Nebbia, Martina, D’Souza, Daniel M., Pascual, Franco, Tohme, Samer, D’Amico, Francesco Enrico, Alessandris, Remo, Panetta, Valentina, Simonelli, Ilaria, Del Basso, Celeste, Russolillo, Nadia, Fiorentini, Guido, Serenari, Matteo, Rotellar, Fernando, Zimitti, Giuseppe, Famularo, Simone, Hoffman, Daniel, Onkendi, Edwin, Lopez-Ben, Santiago, Caula, Celia, Rompianesi, Gianluca, Chopra, Asmita, Abu Hilal, Mohammed, Torzilli, Guido, Corvera, Carlos, Alseidi, Adnan, Helton, Scott, Troisi, Roberto I., Simo, Kerri, Conrad, Claudius, Cescon, Matteo, Cleary, Sean, Kwon, Choon H. D., Ferrero, Alessandro, Ettorre, Giuseppe M., Cillo, Umberto, Geller, David, Cherqui, Daniel, Serrano, Pablo E., Ferrone, Cristina, Mazzaferro, Vincenzo, Aldrighetti, Luca, and Kingham, T. Peter

Published
2023
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