1. The epidemiology of dermatofibrosarcoma protuberans incidence, metastasis, and death among various population groups: A Surveillance, Epidemiology, and End Results database analysis.
- Author
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Maghfour J, Genelin X, Olson J, Wang A, Schultz L, and Blalock TW
- Subjects
- Adolescent, Adult, Aged, Child, Child, Preschool, Female, Humans, Infant, Male, Middle Aged, Young Adult, Head and Neck Neoplasms epidemiology, Head and Neck Neoplasms mortality, Head and Neck Neoplasms pathology, Incidence, Neoplasm Metastasis, Survival Rate, Tumor Burden, United States epidemiology, Black or African American, White, Dermatofibrosarcoma epidemiology, Dermatofibrosarcoma pathology, Dermatofibrosarcoma mortality, SEER Program, Skin Neoplasms pathology, Skin Neoplasms mortality, Skin Neoplasms epidemiology
- Abstract
Background: Limited information exists regarding the epidemiology, metastasis, and survival of dermatofibrosarcoma protuberans (DFSP)., Objective: To measure DFSP incidence and assess metastasis and survival outcomes., Methods: Incidence rate, overall and DFSP-specific survival outcomes for primary DFSP tumors contained in the Surveillance, Epidemiology, and End Results (SEER) registry were analyzed via quasi-Poisson regression, Cox, and competing risk analyses., Results: DFSP incidence rate was 6.25 (95% CI, 5.93-6.57) cases per million person-years with significantly higher incidence observed among Black individuals than White individuals (8.74 vs 4.53). DFSP with larger tumor size (≥3 cm, odds ratio [OR]: 2.24; 95% CI, 1.62-3.12; P < .001) and tumors located on the head and neck (OR: 4.88; 95% CI, 3.31-7.18; P < .001), and genitalia (OR: 3.16; 95% CI, 1.17-8.52; P = .023) were associated with significantly increased risk of metastasis whereas higher socioeconomic status was associated with significantly decreased risk of metastasis. Larger tumor size (≥3 cm), regardless of location, and age (≥60 years) were associated with significantly worse overall and cancer-specific survival., Limitations: Retrospective design of SEER., Conclusion: DFSP incidence is 2-fold higher among Black than White individuals. The risk of DFSP metastasis is significantly increased with tumor size ≥3 cm and tumors located on head and neck, and genitalia. Larger tumor size (≥ 3 cm), regardless of location, and age (≥60 years) are the most important prognostic indicators of survival., Competing Interests: Conflicts of interest None disclosed., (Copyright © 2024. Published by Elsevier Inc.)
- Published
- 2024
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