Search

In the article the main parts of stomatology were presented and the importance of teeth and oral cavity diseases for the general status of the organism are shown. During systemic diseases treatment phisitian must take in account the oral cavity condition for achievent succesive treatment results.

Мета роботи: дослідити вплив гемофільтрації у хворих після мультиорганних оперативних втручань. Матеріали та методи. Вивчались післяопераційні ускладнення у хворих з мультиорганними оперативними втручаннями. Проводились клініко-інструментальні, біохімічні, клінічні, статистичні дослідження; використовувались кардіомонітор Heaco, апарати ультразвукової діагностики й електрокардіографії. Результати. При проведенні в комплексі інтенсивної терапії гемофільтрації та аналізу її впливу на тяжкість стану за шкалами Sequential Organ Failure Assessment і коми Глазго унаслідок гемофільтрації показники тяжкості стану знизились в 1,2 раза. Висновки. Запропонована методика гемофільтрації дозволила знизити число післяопераційних гнійно-септичних ускладнень в основній групі в 1,4 раза і сприяла зменшенню ризику розвитку синдрому поліорганної дисфункції на 33,8 % в основній групі проти групи порівняння.

We report a case of 66-year-old female patient who presented with unstable angina and New York Heart Association Class III symptoms. Echocardiogram demonstrated wall motion abnormalities in the anterior and inferior walls. Coronary angiography demonstrated a severely diseased right coronary artery (RCA) and anomalous left main (LM) coronary artery arising from the right coronary sinus and courses posterior to the aorta and runs between the aorta and the main pulmonary artery with severe multiple atherosclerotic disease. Patient underwent successful coronary artery bypass grafting and was dismissed in good general status.

Summary The concept of inclusion is implemented in Israeli educational system with introduction of 1988 Special Education Law (SEL). The political, socio-cultural and economical changes improved the general status of people with disabilities in the Arab and Jewish communities. However, the Jewish education system, and the Arab education system in general differ, that applies also to the issue of special needs education. Students with disabilities representing minority groups suffer from additional barriers. The main aim of the article is to discuss the issue of integrating students with disabilities into general education in Arab schools in Israel. The situation of children with special educational needs (mainly with intellectual disabilities) in educational system in Israel is discussed, with focus on children from Palestinian-Arab community. The Arab teachers attitudes and behaviors toward the inclusion and disability are analyzed. Although, the research within the topic is limited, the available results indicate rather negative attitudes of Arab teachers towards disabilities. This state might be partly embedded within the socio-cultural context. The further research within the topic is necessary.

Case Presentation A 44-year-old man consulted in April 2020 for a 1-week persistent left lateral chest pain, increased with deep breathing and change of position. He had left lower limb pain without redness or swelling 2 weeks before presentation. He did not complain of shortness of breath, cough, hemoptysis, syncope, fever, nor general status alteration.

Heart failure (HF) is a major cause of death and hospitalization worldwide. In particular, hospital readmission due to worsened HF occurs frequently after the onset of HF. However, the association of repeated hospital admission with clinical manifestations and outcomes is unclear. The aim of this study was to clarify the serial changes in presentation and clinical course of patients requiring repeated hospital admission due to worsened HF. Among 466,921 patients who were admitted and discharged between January 2010 and March 2018, with the main discharge diagnosis of HF, we studied 5,740 patients who were hospitalized 4 times or more, using the Diagnosis Procedure Combination database. We evaluated serial changes in continuous data using the Jonckheere trend test, and categorical data using the Cochran-Armitage trend test. The median age of the patients was 78 years, and 3,326 patients (58%) were male. Body mass index and Barthel Index decreased with increased numbers of admissions. Patients requiring respiratory support and hemodialysis increased, whereas patients undergoing intra-aortic balloon pumping decreased with increased numbers of admissions. The length of hospital stay was prolonged and the interval between hospitalizations was shortened with increased numbers of hospital admissions. The in-hospital mortality rate was 8.8% at the fourth admission. In conclusion, this is the first large-scale real-world study on the serial changes in characteristics and outcomes of HF patients requiring repeated hospitalization, suggesting that repeated hospitalization might adversely affect the general status of patients with HF and result in a vicious clinical cycle.

Absztrakt: Bevezetés: A colitis ulcerosában szenvedő betegpopuláció 20–30%-a szorul élete során sebészi kezelésre. Napjainkban a proctocolectomia ileoanalis pouch képzésével az általánosan elfogadott műtéti módszer, melynél egyre szélesebb körben alkalmazzák a laparoszkópos technikát. Célkitűzés: Az elmúlt 13 évben szerzett tapasztalatainkat mutatjuk be colitis ulcerosa kezelésében a hagyományos és a minimálisan invazív technika vonatkozásában. Módszer: 2005. január 1. és 2018. május 31. között 89 beteg (48 nő és 41 férfi) került műtétre intézetünkben colitis ulcerosa miatt. A betegek átlagéletkora a laparoszkópos és a nyitott csoportban 45,06 ± 14,4, illetve 39,8 ± 13,4 év volt. Vizsgáltuk a műtétre kerülő betegek általános állapotát, a műtéti beavatkozások korai és késői eredményeit, különös tekintettel a szövődményekre és az életminőség változásaira. Eredmények: Perioperatív időszakban a két csoport ápolási napjainak számában (10,3 ± 3,3 vs. 11,2 ± 3,7) és transzfúziós igényében (2,6 ± 2,2 vs. 2,8 ± 1,7) különbséget nem találtunk, azonban a laparoszkópos műtéteket követően az intenzív osztályon töltött napok száma (2,1 ± 0,9 vs. 2,5 ± 1,6) és a passzázs megindulásának napja (1,2 ± 0,5 vs. 1,6 ± 0,7) szignifikánsan rövidebb volt. Hosszú távú szövődmények, mint a passzázszavar, a septicus állapot, a posztoperatív sérvek és az „egyéb” komplikációk száma a laparoszkópos csoportban szignifikánsan kevesebb volt. Az akut műtéteket vizsgálva a laparoszkópia szignifikáns előnye igazolódott a műtét utáni passzázsrendeződés napjainak kapcsán (1,2 ± 0,4 vs. 1,8 ± 0,7). Következtetés: A colitis ulcerosa sebészi kezelésében a minimálisan invazív technika a nyitott műtétekhez képest kedvezőbb perioperatív eredményeket és hosszú távon jobb életminőséget biztosít, a kevesebb késői szövődmény megjelenésének és a betegek stabilabb pszichés állapotának következtében. Orv Hetil. 2020; 161(33): 1363–1372.

Objective. To conduct a comparison analysis of modern open, classic laparoscopic and separation laparoscopic hernioplastic procedures in treatment of ventral and postoperative ventral hernias. Materials and methods. During 2009 - 2019 yrs on the base of Odessa Regional Clinical Hospital 193 patients, suffering ventral and postoperative ventral hernias were operated. Depending on the hernioplasty method applied all the patients were divided on two groups. In the first one 100 patients were exposed to laparoscopic hernioplasty, including 91 patients - the standard laparoscopic operations. In the second group in 93 patients open hernioplasty was performed. Results. In the first group while using a standard laparoscopic procedures of hernioplasty the average duration of operation have constituted (114.0 ± 7.4) min, recurrence was revealed in 7 patients with large hernias (W3). In the second group the operation duration have constituted (130.0 ± 6.1) min, and recurrence was revealed in 8 patients. Conclusion. The operation method choice ought to be individually adjusted, taking into account the patient general status and age, presence of concurrent pathology, as well as the hernia defect dimensions and localization, in particular.

Objective. To assess the results of treatment involving radiation in combination with magnetotherapy for painful bone metastases in patients with breast cancer.Material and methods. The paper presents data from a prospective study of treatment in 163 patients with bone metastases from breast cancer (a control group included 83 patients; a study group consisted of 80 patients). The metastases were more often localized in the vertebrae. Only radiation therapy was used in the control group and was combined with vortex magnetic field magnetotherapy in the study group.Results. The subjective treatment effect by the presence of pain was more commonly recorded in the study group (100% vs 89.2%; p < 0.05). No significant differences in the treatment effect were found in patients with mild pain. In women with moderate pain, the full treatment effect occurred 1.4 times more frequently in the study group than in the control one; the rate of the partial treatment effect was close in the compared groups, and the patients with no effect were significantly fewer in the study group. In women with severe pain, the full treatment effect was noted in 60.5% and 84.1% in the control and study groups, respectively (p = 0.0163); no effect was recorded in 13.2% in the control group and in 0% in the study group (p = 0.0130); there were 26.6% and 15.9% of cases with a partial effect in the control and study groups, respectively (p = 0.2464). Analysis of the patients’ general status according to the Karnofsky performance scale index showed that the pretreatment index ranged from 50 to 70 points in most patients of the control group. After radiation therapy, the indices improved, rising up to 80 points in one-third of patients. Before the treatment, the index in the study group was the same as in the control one; but after treatment it considerably improved and was even equal to 100 points in 7 patients (3 with mild pain before treatment, 1 with moderate pain, and 3 with severe pain).Conclusion. To improve the results of treating bone metastases, we recommend that radiation therapy be combined with a vortex magnetic field, which enhances the analgesic effect and improves the general condition of the patient and his/her quality of life.

Aims and Objectives We evaluated the safety and effectiveness of reestablishing adequate bile flow in patients with malignant obstruction of multilobar self-expanding uncovered metal stents (SEUMSs) inserted for palliative treatment of malignant hilar stenosis, an otherwise fatal setting. From September 1991 to January 2019, 160 patients (100 men and 60 women; median: 69 [range: 37–87] years) with malignant obstruction of multilobar SEUMSs were treated by percutaneous transhepatic external–internal biliary drainage. All patients were followed in their respective oncology services where they were treated (or not) according to local protocols adapted to their disease and overall general status. Result External–internal biliary drainage was successful in all 160 patients. All patients were discharged within 5 days. Both immediate (4 patients; 2.5%) and late complications (29 patients; 18%) were managed successfully with minimal morbidity and no mortality. After reestablishment of adequate bile flow, the median survival was 191 days (range: 2–5,668 days). Forty-one (25.6%) patients survived for more than 12 months, and 10 (6.2%) survived for more than 3 years. Conclusion In our series, external–internal biliary drainage was safe and effective; it was life-saving and afforded acceptable quality of survival for patients who otherwise would have been left untreated with short-term fatality.

Objective. The chewing group of teeth is intended for equally crusher of food and forming food lump. This group is presented by two kinds of teeth: premolars and molars, and more often affected by caries, because a lot of retention zones are contribute to the active delay of plaque and the appearance of carious cavities. It is happening before 18 years. In the absence of these teeth or badly damaged of the crown part, food is chewed badly and as a result, stomach contain extremely large pieces. But its size is impossible for physiological digestion by the gastrointestinal tract and as a consequence the occurrence of gastrointestinal diseases. According to modern data, to work with lesions of hard tissues of the teeth, namely the chewing group of teeth, it is advisable to use composite light-curing microhybrid materials, which are characterized by particles close to the spherical shape. The aim of this study is determination of the possibility using a budgetary aesthetic composite for restorative restoration of the masticatory group of teeth in patients with a burdened anamnesis. Material and methodology. Was examined 22 people with aesthetic and anatomical disorders of the vestibular and occlusal surface of the hard tissues of the chewing group of teeth (n=154), followed by their recovery. The stability of filling materials was assessed according to Ryge-criteria: color coincidence, discoloration of the marginal segment, marginal adaptation, anatomical shape integrity, restoration surface, secondary caries. Results. Clinical and dental examination showed all the above violations of existing restorations (according to Ryge classification) in patients before restoration manipulations. After 1 week after the restoration, the examination showed that both groups of composites completely restore the anatomical and aesthetic chewing group of teeth and meet all the criteria. After 3 months, the assessmen t of the restoration by the composite of group A and group B did not reveal evidence of secondary caries on the perimeter of the restorations. Clinical and dental examination after 6 months showed minor changes in the restorations of composites of both groups in assessing the stability of color (90.9% and 83.3% in groups A and B) and the stability of surface polishing (89.6% and 81.8%, respectively). Discussion. The main signs of the restoration, which are undergoing changes, are discoloration, as well as the preservation of the smoothness of the surface regardless of the cost and branding of the base material.

Purpose This paper is based on the doctoral study conducted in 2016 at the University of South Africa. The purpose of this study was to investigate how the current state of management of electronic records in Kenya facilitates or undermines implementation of e-government with a view to develop a best-practice framework for management of electronic records in support of e-government. Design/methodology/approach The study used the interpretive research paradigm and adopted qualitative research methodology using phenomenological design. Maximum variation sampling was used to identify the research sample for the study. Findings The findings established that the general status of management of e-records (MER) in government ministries is inadequately positioned to support e-government; use of e-government in Kenya had grown significantly and more ministries were adopting e-government services; although some initiatives have been undertaken to enhance MER, the existing practices for MER require improvement to ensure they adequately support e-government. Research limitations/implications The limitations were access to respondents and the challenge of self-reported data. Practical implications Recommendations and a best-practice framework for managing electronic records in support of e-government have been provided. A proposal for implementation of the recommendations on a priority basis has also been provided. Social implications The study’s contribution to scholarly works and literature in the field resides in its findings and a framework that can be practically adopted for management of e-records in support of e-government. By establishing the nexus between management of e-records and e-government in Kenya, it is hoped that it will provide input to policymakers to consider records managers as key stakeholders in e-government. Originality/value The originality of this study stems from two aspects: original topic and understudied area.

Background Torque teno virus-induced aseptic meningitis has not been documented, although torque teno virus infections still remain under consideration for etiological agents. This study identified a torque teno virus sequence using next generation sequencing and immunoglobulin M response to the torque teno virus antigen, therefore, that would be a comprehensive diagnosis for torque teno virus infection. Case presentation A 2-month-old Japanese boy was brought to our hospital because he was irritable, drowsy, and lethargic. He was admitted based on his test results which indicated the possibility of septic meningitis. He was started on treatment with high-dose antibiotics and steroids. On the third day of hospitalization, he became afebrile with improvement in his general status and was discharged on the sixth day. He had no developmental problems for up to 1 year after discharge. Metagenomic ribonucleic acid-Seq pathogen detection using next generation sequencing of a sample of his cerebrospinal fluid, which was collected at admission, revealed three short reads homologous to those in torque teno virus out of a total of 1,708,516 reads. This finding indicated that our patient was positive compared to the torque teno virus-negative cerebrospinal fluid samples (controls) from 13 other patients. The torque teno virus has been shown to have a whole genome sequence of 2810 nt by polymerase chain reaction. We prepared a recombinant GP2 antigen from torque teno virus and used it to study our patient’s anti-torque teno virus immune response. An anti-GP2 serum immunoglobulin M response was detected, providing further supportive evidence of torque teno virus infection. Conclusions This case speculates that torque teno virus-induced aseptic meningitis has a good course. New technologies like next generation sequencing can help in the identification of such cases, and an accumulation of future cases is expected.

Introduction. Slow fl uctuations in the volume and pressure of liquids in the cranial cavity have been known for a long time and have been studied for more than 100 years. However, their quantitative indicators and their practical signifi cance remain unclear until now due to the diffi culties of research. Nevertheless, it was found that they were connected with the brain activity, which made it possible to use them as one of the physiological indicators in studying the problems of manned space fl ights. Goal of research — to study the possibility of using spectral analysis of slow fl uctuations of the volume of liquids inside the cranium in order to realize the quantitative assessment of their indicators with the use of modern microelectronics and computer technology.Materials and methods. In order to solve this problem we created a complex, in which rheoencephalograph-RG-01 («Mizar») was used as a converter-modulator of physiological signals into electrical oscillations. The device was connected with the ADC (Firm «ADIstrument»), Its software allows to calculate the spectrogram with a sampling rate of 128 kHz. Studies were conducted on volunteers of younger, middle and older age groups. The respiratory rate and the electrocardiography were registered together with the rheoencephalography. Electrodes were fi xed on the volonteers′ fronto-mastoid area.Results. Slow fl uctuations the cranium representan independent physiological phenomenon. The most considerable and valuable were fl uctuations in 0,1–0,3 Hz. It was found that current frequency of 100 or 200 kHz and frequency for quantization of 80–100 kHz was optimal for performing their spectrograms. The structure of such diagram consists of 4–7 peaks with amplitude of 0,4–0,7 units compared with REG pulse amplitude. They depend on age and are characterized by hemispheric asymmetry. Spectral diagrams of slow fl ucation inside cranium are representing inpendent physiological phenomenon. These fl uctuations are not connected by common origin, with heart activity and respiration. They are connected by nature with brain activity and PRM.Conclusion. Can be an informative method for diagnostic and assessment of general status of osteopathic patients well as for the assessment of mechanisms of action of some osteopathic techniques.

The pathological diagnostics of cancer - based on the histological features - is today increasingly completed by molecular profiling at variable depth in an almost evident fashion. Predictive information should cover potential therapeutic targets and/or major resistance mechanisms the nature of which is subject of alteration during the course of the treatment. Mutational profiling recently became technically available by the analysis of circulating free DNA obtained following non-invasive peripheral blood or body fluid sampling. This "liquid biopsy" approach reflects the general status considering the actual tumor burden, irrespective of the intratumoral distribution and anatomical site. However, the dynamics of the liquid compartment relies on tissue-related processes reflected by histological variables. The amount and composition of free DNA seems to be influenced by many factors, including the stage and anatomical localization of the cancer, the relative mass of neoplastic subclones, the growth rate, the stromal and inflammatory component, the extent of tumor cell death and necrosis. The histopathological context should be considered also when analysis of cfDNA is about to replace repeated tumor sampling for molecular follow-up.

Skin and mucous membrane lesions are significant clinical manifestations of HIV infection. Dermatoses associated with HIV infection are characterized by persistent, increasing severity. Atypical symptoms may occur. These dermatoses are resistant to therapy. They are often associated with lymphadenopathy. These criteria are sufficient grounds for supposing the presence of HIV infection, especially when taking into account visceral and systemic abnormalities, as well as the general status of the patient.Up to 92 % of HIV-infected people suffer from various dermatoses. In 72 % of patients, two or more skin diseases occur simultaneously. Skin and mucous membrane lesions in patients with HIV are often one of the first manifestations of HIV infection. Hence, the role of the dermatovenerologist consists in the timely detection of HIV infection. The spectrum of skin lesions in HIV infection is extremely wide. Conventionally, there are three main groups of dermatoses: infectious, non­infectious and neoplastic.Clinical examples were given of skin pathologies manifestation in HIV­infected patients as the first HIV infection display in the patients.Examination on HIV infection was conducted in the clinicodiagnostic laboratory of regional communal establishment «Kryvyi Rih Dermatovenerologic dispensary» with making rapid immunochromatographic tests «Wantai Bio­Pharm» and carrying out immunoassay studies using immunoassay systems for the determination of antibodies to the human immunodeficiency virus of the first and second types «Recombinant-HIV 1,2-MBA MedBioAlliance, Ukraine».HIV-­status in the inspected patients was confirmed by the reference­laboratory of Kryvyi Rih AIDS Prevention and Cont­rol Centre. Clinical cases of HIV infection in patients with various dermatoses were considered, in particular, in a patient with seborrheic dermatitis and disseminated streptoderma, in a patient with pustular psoriasis, in a patient with rosacea. Cases of HIV associated with toxicoderma and urticaria were described.The presence of various opportunistic infections in HIV-infected patients, as well as various dermatological manifestations, requires greater vigilance of dermatologists and family doctors as first-time doctors in order to improve timely diagnosis and treatment effectiveness.

International audience; There exist many different human cancers, but regardless of the cancer type, an early diagnosis is a necessary condition for further optimal outcomes from the disease. Therefore, efficient specific and sensitive cancer biomarkers are urgently needed. This is especially true for the cancers depicting a silent progression, and those only diagnosed in an already metastatic state with a poor survival prognostic. After a rapid overview of the previous methods for cancer diagnosis, the outstanding characteristics of extracellular vesicles (EVs) will be presented, as new interesting candidates for early cancer diagnosis in human biofluid non-invasive liquid biopsy. The present review aims to give the state-of-the-art of the numerous searches of efficient EV-mediated cancer diagnosis. The corresponding literature quest was performed by means of an original approach, using a powerful Expernova Questel big data platform, which was specifically adapted for a literature search on EVs. The chosen collected scientific papers are presented in two parts, the first one drawing up a picture of the current general status of EV-mediated cancer diagnosis and the second one showing recent applications of such EV-mediated diagnosis for six important human-specific cancers, i.e., lung, breast, prostate, colorectal, ovary and pancreatic cancers. However, the promising perspective of finally succeeding in the worldwide quest for the much-needed early cancer diagnosis has to be moderated by the many remaining challenges left to solve before achieving the efficient clinical translation of the constantly increasing scientific knowledge.

Introduction Frantz's tumor of the pancreas is a rare phenomenon, and it accounts for 1–3% of all neoplasms of the pancreas. Its percentage is much higher in younger persons, especially in younger women, as compared to the rest of the population. Presentation of case The present study describes a 32-year-old female patient in whom a preoperative imaging diagnosis confirmed a mass in the junction of the pancreas' body and tail. Based on the anamnesis, the preoperative diagnosis, and the patient's general status, the decision was made to performed laparoscopic enucleation of the pancreatic tumor. The operation and postoperative recovery passed without complications. Definitive histopathological and immunohistochemical findings confirmed a solid pseudopapillary neoplasm of the pancreas. Discussion Depending on the localization and the size of the tumor, surgical options range from typical and atypical resections of the pancreas to minimally invasive surgical procedures, such as local excision and enucleation. Laparoscopic procedures have a comparative advantage in cases of enucleation and resection of the pancreas. The low frequency of recidivation and a favorable prognosis, even after repeated surgery, are additional reasons for favoring the laparoscopic approach over the classical surgical approach. Conclusion A minimally invasive surgical approach should be applied whenever the dimensions and the localization of the tumor permit it, bearing in mind all the benefits and advantages that this surgical technique offers., Highlights • Solid pseudopapillary neoplasm of the pancreas, is known as Frantz's tumor. • Around 1,000 cases of Frantz's tumor have been described. • 32-year-old patient underwent laparoscopic enucleation of an 18 mm pancreatic tumor. • Laparoscopic enucleation is a feasible option for the treatment of these masses.

The Italian Society of Doctors for the Environment – ISDE Italy is an environmental organization of medical doctors. It is an independent, non-profit organization affiliated to the International Society of Doctors for the Environment – ISDE (which has a Consultative Status with WHO and a Consultative General Status with ECOSOC and fosters co-operative efforts with different other international organizations and many NGOs). The main purpose of ISDE Italy is to help defend environment both locally and globally to prevent numerous illnesses, ensure the necessary conditions for health, and improve the quality of life. It aims to educate and update physicians and the general public and stimulate awareness and initiatives by public and private bodies. ISDE Italy collaborates with different national, regional and local organizations, networks and NGOs as well. All ISDE Italy projects follow an integrated model finalized to actions which are generally preceded by training moments.

Purpose This study was conducted to analyze the anxiety levels and attitudes of nursing students for the nursing profession during the COVID‐19 pandemic. Methods Data collection forms were sent online to nursing students of three different state or foundation universities in Turkey. In all, 456 individuals who answered the data collection forms were included in the study. Findings Study results revealed that the total average score for the “Attitude Scale for Nursing Profession” was 162 ± 15.6. The Professional characteristics subdimension score average was 80.64 ± 7.02. Furthermore, the state of choosing nursing profession subdimension score average was 50.05 ± 9.23, whereas the Attitude for the general status of nursing profession subdimension score average was 34.38 ± 2.97. Due to the pandemic, anxiety levels for the nursing profession were 4.86 ± 2.76 (between 0 and 10). It was determined that nursing students who studied in cities where the virus was very common had a more positive attitude toward the profession. Anxiety levels of nursing students studying in cities where the virus impact was moderate and in cities where the virus presence was quite common were higher (p > 0.05). Practical Implications It was found that nursing students had a positive and high‐level attitude toward the nursing profession. Furthermore, the results demonstrated that attitudes toward the nursing profession decreased significantly as anxiety increased.

We present a unique case of multiple junctional vertebra fractures in a single patient requiring surgical intervention, the variety of which has not yet been reported in the literature. A 15-year old female was admitted to our emergency department after a suicide attempt from jumping from the window of a five-floor building. On admission her general status was critical, Glasgow Coma Scale (GCS) was 6, and on painful stimuli she was able to move all four extremities. On her spinal CT, a C1 right arcus fracture, a C7 corpus fracture, an L3 and L5 burst fracture and a right sacrum fracture were detected. The patient also suffered from pneumothorax, pleural effusion and pulmonary contusions. After she was stable and extubated, she did not show any motor or sensory deficits. As the patient still had some pleural effusion and pulmonary contusions, posterior approaches were avoided at first and a C6-T1 anterior stabilization with mini plate-screws was performed. After her pulmonary problems resolved, a series of spinal instrumentation surgeries were performed over the following weeks. A case like this in which multiple traumatic junctional fractures were treated with different surgical techniques has not been reported in the literature before. It is important to emphasize if and when surgical intervention is needed. A multidisciplinary assessment of trauma surgeons, neurosurgeons and anesthesiologists is vital for forming a further treatment plan.

Objective to analyze the sociodemographic, obstetric, type of delivery and professional factors that provided care that can influence the quality of life related to women's health in the immediate puerperium period. Method cross-sectional, correlational study conducted in a reference maternity hospital, with 272 women in the immediate puerperium period hospitalized in the rooming-in accommodation. A sociodemographic, clinical and obstetric questionnaire and the Short Form Health Survey-36 scale were used to assess health-related quality of life. Results regarding age, there was a significant association in the domains functional capacity and general status, with better scores for ages up to 29 years. Regarding education, significance was observed in the functional capacity domain with better scores for 9 to 11 years of schooling. The analysis of obstetric complications showed statistical significance in the general health status domain p

Purpose: Treatment of hypertension has recently shown remarkable advances. It is quite important to survey the current general status of blood pressure (BP) and recent changes to verify whether peo...

We report a case of 66-year-old female patient who presented with unstable angina and New York Heart Association Class III symptoms. Transthoracic Echocardiogram demonstrated severe wall motion abnormalities in the anterior and inferior walls of the heart. Coronary angiography demonstrated a severely diseased right coronary artery and an anomalous left main coronary artery arising from the opposite coronary sinus and courses posterior to the aorta and runs between the aorta and the main pulmonary artery with severe multiple atherosclerotic disease. Patient underwent successful coronary artery bypass grafting and was dismissed in good general status.

This study aimed to assess the masticatory efficiency in patients with a removable dental prosthesis, presenting different systemic, oral and prosthetic states while chewing different foods. The study was conducted on a convenient sample of patients aged 45 and above, with removable prostheses in at least one jaw. Patients were asked to chew samples of digestive biscuits, apple, and carrot, until the sensation of swallowing. The recorded masticatory function parameters were: chewing time, the number of mastication cycles, mean masticatory cycle duration, and chewing frequency. We found out that the masticatory functional parameters registered statistically significant differences according to the chewed food (e.g., generally the highest values were recorded for carrot and lowest for apple), most likely this being in relation to food’s consistency, wetting, and adherence. High positive correlations were found between the chewing time and the number of mastication cycles for all three foods taken into consideration. Higher values for chewing time and number of mastication cycles were found for all foods in patients with complete dentures and overdentures, and while chewing carrot in patients with altered general status and of advanced age. Therefore, it that it takes a different time and number of mastication cycles to complete chewing, in relation to individual and food characteristics, to the systemic, oral and prosthetic patient’s status. The residual teeth number and the type of prosthetic rehabilitation favor the adaptation and improvement of masticatory parameters and can have marker value for masticatory efficiency.

Background and importance Non-ketotic hyperglycinaemia (NKH) is a rare inborn error of glycine metabolism characterised by accumulation of glycine in body fluids and tissues, resulting in neurometabolic symptoms of variable severity. Sodium benzoate is the sodium salt of benzoic acid that conjugates with nitrogen containing glycine to form the molecule hippurate. Hippurate can be excreted by the kidneys, reducing plasma glycine levels. N-methyl-D-aspartate receptor antagonists may ameliorate neurological symptoms although it remains to be established whether they improve long term outcome. Lack of authorised presentations for treatment of rare diseases is an important obstacle that is usually resolved by hospital pharmacy formulations, especially in children. Aim and objectives The aim was to provide an adequate, stable and well accepted oral sodium benzoate formulation for a patient with NKH, to improve her general status Material and methods A 4-year-old girl with severe NKH needed oral treatment with sodium benzoate, although there is no standard oral formulation for children. To find an optimal and suitable solution, a literature search was carried out in the National Library of Medicine’s (MEDLINE) database, including terms ‘sodium benzoate/chemistry’, and ‘administration, oral’ with no other filter. Our national and regional formulation databases were also checked. Results The patient was initially treated with 16 mL, three times a day, sodium benzoate syrup 112.5 mg/mL, but the volume needed was impossible to swallow by the patient due to her clinical status. Subsequently, 2 g sodium benzoate sachets were given with meals (four times a day) but they were not well tolerated. We then dispensed a 250 mg/mL suspension in Ora-Sweet with a stability of 90 days. Despite it being a new formulation for our pharmacy service, glycine levels were reduced from 900–1000 µ/L to 500 µ/L over 2 months. Currently, her clinical situation is stable, and the patient receives 8 g/24 hours of sodium benzoate which is well tolerated. Conclusion and relevance Sodium benzoate oral suspension dispensed with Ora-Sweet seemed to be an adequate solution to NKH treatment in our patient. Although the formulation is a basic operation for hospital pharmacy services, it is essential, especially in children with rare diseases that need orphan drugs. References and/or acknowledgements No conflict of interest.

In this article we will argue that beyond its general status and identity as the supreme law of South Africa, the 1996 constitution2 (hereinafter the constitution) is also a historiographical parad...

Camping industry is growing largely, and in the case of Korea, recently, the demand of camping is increasing greatly. However, in the case of Korea, it is hard to get policy support or regulation efficiently since even the precise situation survey is not grasped. Accordingly, this study conducted a research on the actual condition of the complete enumeration for camping grounds in the whole country under judgment that the related investigation is urgent. It estimated average operation rate and the number in domestic camping grounds drawing effective sample. As a result, it was estimated that 15.4% as average operation rate in domestic camping grounds, 6,071 as number of common employees (62.2%), 3,684 as number of daily employees (37.8%) in total 9,766 (100.0%) employees. This research on the actual condition would contribute to improve convenience and to prevent negligent accidents for users investigating general status and holding facilities together. If the research would be continued, it would be helpful to prepare a standard for safe and diverse camping activities and support for continuing industrial development as grasping economic scale of camping industry.

Parathyroid hormone-related protein (PTHrP), which is released in the presence of malignant disease, is associated with hypercalcemia. Complete resection of the tumor in such patients is rarely performed because of their poor general condition. We herein report a case of lung cancer associated with PTHrP in a patient whose condition dramatically improved after surgery. We also review the literature on the benefits of various surgical options. Although only a few cases of complete resection in such patients have been reported, the mental and physical condition of the patients improved postoperatively and the median survival time was longer than 12 months. A poor general status is frequently considered a contraindication for surgery, even in a palliative setting; however, we conclude that resection of lung cancer may lead to improved symptom control and survival when the patient’s condition is induced by hypercalcemia secondary to PTHrP secretion from the tumor.