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Photothermal therapy (PTT) of nanomaterials is an emerging novel therapeutic strategy for breast cancer. However, there exists an urgent need for appropriate strategies to enhance the antitumor efficacy of PTT and minimize damage to surrounding normal tissues. Piezo1 might be a promising novel photothermal therapeutic target for breast cancer. This study aims to explore the potential role of Piezo1 activation in the hyperthermia therapy of breast cancer cells and investigate the underlying mechanisms. Results showed that the specific agonist of Piezo1 ion channel (Yoda1) aggravated the cell death of breast cancer cells triggered by heat stress in vitro. Reactive oxygen species (ROS) production was significantly increased following heat stress, and Yoda1 exacerbated the rise in ROS release. GSK2795039, an inhibitor of NADPH oxidase 2 (NOX2), reversed the Yoda1-mediated aggravation of cellular injury and ROS generation after heat stress. The in vivo experiments demonstrate the well photothermal conversion efficiency of TiCN under the 1,064 nm laser irradiation, and Yoda1 increases the sensitivity of breast tumors to PTT in the presence of TiCN. Our study reveals that Piezo1 activation might serve as a photothermal sensitizer for PTT, which may develop as a promising therapeutic strategy for breast cancer.

The national image is a overall evaluation and confirmation of a nation, identified by the public at home and abroad. It's the strategic objectives pursued by governments, as well as significant means of seeking national strategic interests. The creation and dissemination of national image is directly related to the international status and influence. There's no doubt that, with rapid development of information technology, it is becoming a new significant approach and method to create the national image through the internet, as well as disseminate it. [ABSTRACT FROM AUTHOR]

The samples of aerated concrete were successfully prepared in line with GB/T 11968-2006 of the A3.5, B06-class by low-silica iron ore tailings as the main raw material, aluminum powder as gas evolution agent. Iron ore tailings, silica sand, lime, cement and gypsum with the optimized ratio (mass ratio) was 40 : 20 : 25 : 10 : 5 in the case of maximizing the use of iron ore tailings, aluminum powder was added at 0.057%, water/solide ratio was 0.57, the static stop curing at 70 °C, the compressive strength and the calculated specific strength of the finished aerated concrete samples with the bulk density of 590 kg/m³ were 4.11 and 6.97 MPa. The major mineral phases in the aerated concrete product were tobermorite with residue quartz and anhydrite. SEM and EDS results show that the finished product to form a network structure by CSH and tobermorite, the compressive strength of aerated concrete samples are effectively improved. [ABSTRACT FROM AUTHOR]