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Background: SAPHO syndrome is recognized as a rare entity with damage to skin and bones due to inflammation. Currently, the treatment for SAPHO syndrome is still a challenge in clinical practice. In this study, an integrated transcriptomics and network pharmacology approach was applied to explore the therapeutic effect and mechanism of Wang‐Bi tablet (WBT) on SAPHO syndrome. Methods: The main components of WBT and their targets, as well as the targets of SAPHO syndrome, were collected from databases. Network visualization was performed using Cytoscape software. The GO and KEGG enrichment analysis was executed by David dataset. Then, the molecular mechanism of WBT improving SAPHO syndrome was validated by transcriptomics of peripheral blood neutrophils in SAPHO syndrome. Finally, the above results were validated by molecular docking. Results: The Network Pharmacology results showed there are 152 core targets for WBT treatment on SAPHO syndrome. RNA‐seq data showed 442 differentially expressed genes (DEGs) in peripheral blood neutrophils of SAPHO patients. Intriguingly, NIK/NF‐kappaB‐, MyD88‐dependent toll‐like receptor‐, and MAPK pathway were included in the enrichment results of network pharmacology and RNA‐seq. Moreover, we verified that the core components of WBT have good affinity with the core targets of NIK/NF‐kappaB‐, MyD88‐dependent toll‐like receptor‐, and MAPK pathway by molecular docking. Conclusions: This study illustrated that the possible mechanisms of WBT against SAPHO syndrome may be related to NIK/NF‐kappaB‐, MyD88‐dependent toll‐like receptor‐, and MAPK pathway, and further experiments are needed to prove these predictions. [ABSTRACT FROM AUTHOR]

This article discusses the importance of magnetic resonance imaging (MRI) in diagnosing and differentiating spondyloarthritis (SpA) from other conditions. The authors emphasize that bone marrow edema in the sacroiliac joint, commonly associated with SpA, can also be seen in tumors, infections, degeneration, and sacroiliac joint gout. To avoid misdiagnosis and mistreatment, rheumatologists need to be familiar with the clinical characteristics and imaging features of different diseases. The article presents a retrospective analysis of 10 cases of lymphoma that mimicked SpA, providing clinical data, laboratory examinations, and imaging features of these patients. It highlights the importance of imaging techniques, such as x-rays, CT scans, and MRI, in diagnosing SpA and detecting bone lymphoma, a rare condition that can mimic the symptoms of SpA. Rheumatologists should be aware of the similarities between SpA and bone lymphoma to ensure accurate diagnosis and appropriate treatment. [Extracted from the article]