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11 results on '"Gennarelli D"'

2. HLA-related genetic risk for coeliac disease

Author

Limongelli, Mg, Bourgey, M, Calcagno, G, Tinto, N, Gennarelli, D, Margaritte-Jeannin, P, Esposito, O, Marano, C, Troncone, R, Spampanato, A, Natale, C, Clerget-Darpoux, F, Sacchetti, L, Greco, L, Génétique épidémiologique et structures des populations humaines (Inserm U535), Epidémiologie, sciences sociales, santé publique (IFR 69), Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris-Sud - Paris 11 (UP11)-École des hautes études en sciences sociales (EHESS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris-Sud - Paris 11 (UP11)-École des hautes études en sciences sociales (EHESS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), SPeS Dipartiment, Università degli studi del Molise, Department of Biochemistry and Medical Biotechnology, Università degli studi di Napoli Federico II, Department of Pediatrics and European Laboratory for the Investigation of Food-Induced Diseases, FRM (Fondation de la Recherche Médicale ), ELFID (European Laboratory for the Investigation of Food-Induced Diseases), CEINGE, Regione Campania, • MIUR (Italian Ministero dell'Istruzione, dell'Università e della Ricerca), Vaillant, Christine, Università degli Studi del Molise = University of Molise (UNIMOL), University of Naples Federico II = Università degli studi di Napoli Federico II, Limongelli, Mg, Bourgey, M, Calcagno, G, Tinto, N, Gennarelli, D, MARGARITTE-JEANNIN, P, Esposito, O, Marano, C, Troncone, R, Spampanato, A, CLERGET- DARPOUX, F, Sacchetti, L, and Greco, L.

Subjects
Male, Parents, Proband, Pediatrics, medicine.medical_specialty, Genotype, Genetic counseling, Genetic Counseling, [SDV.GEN] Life Sciences [q-bio]/Genetics, Coeliac Disease, Risk Assessment, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, HLA-DQ Antigens, Humans, Medicine, Genetic Predisposition to Disease, First-degree relatives, Risk factor, 030304 developmental biology, Family Health, 0303 health sciences, [SDV.GEN]Life Sciences [q-bio]/Genetics, business.industry, Siblings, DQ-typing, Infant, Newborn, Gastroenterology, 3. Good health, HLA, Celiac Disease, Risk Estimate, family screening, Haplotypes, Cohort, Immunology, Female, 030211 gastroenterology & hepatology, first degree relatives, Risk assessment, business, Cohort study, recurrence risk
Abstract

Background: Several studies have shown an elevated prevalence of coeliac disease (CD) in sibs of coeliac patients (risk 8-12%). Aim and method: This study seeks to evaluate the risk that sibs of children with CD will also develop CD. This cohort of 188 Italian families was composed of probands with CD, at least one sib, and both parents. CD status was determined and HLA-DQ genotyping performed for all family members. The study also used a data set of Italian triads (127 probands and both their parents) also genotyped for HLA-DQ. Results: The overall risk that a sib of a CD patient will develop the disease is estimated at 10% in this sample. The risk estimate ranges from 0,1 to 29% when HLA-DQ information of the proband, parents and sib is considered. We found a negligible risk (lower than 1%) for 40% of the sibs of probands, a risk greater than 1% but less than 10% for 30%, and finally a high or very high risk (above 25%) in one third of families. Conclusion: These results make it possible to provide more accurate information to parents with child with CD about the real risk for another child. An antenatal estimate of the order of risk of CD is now possible. Specific follow-up can thus be offered for babies at high risk.

Published
2007
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3. HLA and MICA antibodies and graft outcome in 448 kidney transplanted patients

Author

Piazza A, Poggi E, Ozzella G, Scornajenghi KA, Borrelli L, Gennarelli D, Tisone G, and Adorno D.

Subjects
body regions, surgical procedures, operative
Abstract

It has been suggested that post-transplant development of donor-specific antibodies (DSA) represents a negative prognostic factor in kidney transplantation. This study analysed the impact of post-transplant HLA- and MICA-DSA on kidney graft outcome. A 16-year monitoring of HLA-DSA was performed on 448 kidney transplanted patients by flow cytometric techniques.

Published
2007

8. HLA related genetic risk for coeliac disease

Author

Bourgey, M., primary, Calcagno, G., additional, Tinto, N., additional, Gennarelli, D., additional, Margaritte-Jeannin, P., additional, Greco, L., additional, Limongelli, M. G., additional, Esposito, O., additional, Marano, C., additional, Troncone, R., additional, Spampanato, A., additional, Clerget-Darpoux, F., additional, and Sacchetti, L., additional

Published
2007
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10. GENETIC RISK OF FIRST DEGREE RELATIVES OF COELIAC PATIENTS

Author

M. G. Limongelli, M. Bourgey, G. Calcagno, N. Tinto, D. Gennarelli, P. Margaritte Jeannin, O. Esposito, C. Marano, R. Troncone, A. Spampanato, C. Natale, F. Clerget Darpoux, L. Sacchetti, L. Greco, Limongelli, M. G., Bourgey, M., Calcagno, G., Tinto, N., Gennarelli, D., Margaritte Jeannin, P., Esposito, O., Marano, C., Troncone, R., Spampanato, A., Natale, C., Clerget Darpoux, F., Sacchetti, L., and Greco, L.

Published
2005

11. Hereditary fructose intolerance and celiac disease: a novel genetic association.

Author

Ciacci C, Gennarelli D, Esposito G, Tortora R, Salvatore F, and Sacchetti L

Subjects
Adult, Age Factors, Child, Child, Preschool, Female, Follow-Up Studies, Fructose Intolerance diagnosis, Fructose Metabolism, Inborn Errors complications, Fructose Metabolism, Inborn Errors diagnosis, Fructose Metabolism, Inborn Errors genetics, HLA-DQ Antigens genetics, HLA-DR Antigens genetics, Humans, Incidence, Italy epidemiology, Pedigree, Retrospective Studies, Risk Assessment, Sampling Studies, Severity of Illness Index, Celiac Disease complications, Celiac Disease diagnosis, Fructose Intolerance complications, Fructose Intolerance genetics, Genetic Predisposition to Disease, Mutation
Abstract

Background & Aims: Celiac disease (CD) has been associated with several genetic disorders, but has not been associated with hereditary fructose intolerance (HFI)., Methods: We identified CD in 4 female patients affected by HFI from among 38 Italian HFI patients., Results: Three of these patients were children in whom the CD-associated signs were hypertransaminasemia, failure to thrive, low weight, and short stature, whereas the adult patient had protracted diarrhea notwithstanding a fructose-free diet. The incidence of CD in our group of HFI patients was higher (>10%) than in the general population (1%-3%) (P<.02)., Conclusions: The possibility of an association between these 2 gastrointestinal disorders is important, particularly in the management of HFI patients with persisting symptoms.

Published
2006
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