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4 results on '"Genuíno de Oliveira, Mariana Barros"'

1. NR3C1 gene methylation and cortisol levels in preterm and healthy full-term infants in the first 3 months of life

Author

Chalfun, Georgia, primary, Araújo Brasil, Aline de, additional, Paravidino, Vitor Barreto, additional, Soares-Lima, Sheila Coelho, additional, Souza Almeida Lopes, Monique de, additional, Santos Salú, Margarida dos, additional, Barbosa E dos Santos, Paulo Victor, additional, P da Cunha Trompiere, Ana Carolina, additional, Vieira Milone, Leo Travassos, additional, Rodrigues-Santos, Gustavo, additional, Genuíno de Oliveira, Mariana Barros, additional, Robaina, Jaqueline Rodrigues, additional, Lima-Setta, Fernanda, additional, Reis, Marcelo Martins, additional, Ledo Alves da Cunha, Antônio José, additional, Prata-Barbosa, Arnaldo, additional, and de Magalhães-Barbosa, Maria Clara, additional

Published
2023
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2. Rare genetic variants involved in multisystem inflammatory syndrome in children: a multicenter Brazilian cohort study.

Author

Santos Dos Reis, Bάrbara Carvalho, Soares Faccion, Roberta, Anisio de Carvalho, Flavia Amendola, Cox Moore, Daniella Campelo Batalha, Chaves Zuma, Maria Celia, Plaça, Desirée Rodrigues, Salerno Filgueiras, Igor, Mathias Fonseca, Dennyson Leandro, Cabral-Marques, Otavio, Cesar Bonomo, Adriana, Savino, Wilson, de Paula Freitas, Flάvia Cristina, Faoro, Helisson, Passetti, Fabio, Rodrigues Robaina, Jaqueline, Caino de Oliveira, Felipe Rezende, Novaes Bellinat, Ana Paula, de Seixas Zeitel, Raquel, dos Santos Salú, Margarida, and Genuíno de Oliveira, Mariana Barros

Subjects
MULTISYSTEM inflammatory syndrome in children, GENETIC variation, INTERFERON gamma, EXOMES, MUCOCUTANEOUS lymph node syndrome, INTERFERON receptors, MULTISYSTEM inflammatory syndrome
Abstract

Introduction: Despite the existing data on the Multisystem Inflammatory Syndrome in Children (MIS-C), the factors that determine these patients evolution remain elusive. Answers may lie, at least in part, in genetics. It is currently under investigation that MIS-C patients may have an underlying innate error of immunity (IEI), whether of monogenic, digenic, or even oligogenic origin. Methods: To further investigate this hypothesis, 30 patients with MIS-C were submitted to whole exome sequencing. Results: Analyses of genes associated with MIS-C, MIS-A, severe covid-19, and Kawasaki disease identified twenty-nine patients with rare potentially damaging variants (50 variants were identified in 38 different genes), including those previously described in IFNA21 and IFIH1 genes, new variants in genes previously described in MIS-C patients (KMT2D, CFB, and PRF1), and variants in genes newly associated to MIS-C such as APOL1, TNFRSF13B, and G6PD. In addition, gene ontology enrichment pointed tothe involvement of thirteen major pathways, including complement system, hematopoiesis, immune system development, and type II interferon signaling, that were not yet reported in MIS-C. Discussion: These data strongly indicate that different gene families may favor MIS- C development. Larger cohort studies with healthy controls and other omics approaches, such as proteomics and RNAseq, will be precious to better understanding the disease dynamics. [ABSTRACT FROM AUTHOR]

Published
2023
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3. Mental Health and Emotional Disorders During the COVID-19 Pandemics: Prevalence and Extent in PICU Staff.

Author

Lima-Setta, Fernanda, Leite de Moraes, Claudia, Nunes Costa Silami, Pedro Henrique, Reichenheim, Michael Eduardo, de Mello e Silva, Juliana Freitas, Stochero, Luciane, Genuíno de Oliveira, Mariana Barros, Rodrigues Robaina, Jaqueline, Rodrigues-Santos, Gustavo, Gustavo de Almeida, Carlos, Amoretti, Carolina Friedrich, Novaes Bellinat, Ana Paula, Bromonschenkel Brandão, Igor, Barbosa de Carvalho, Patrícia, Viana Falcão, Ricardo, Gregory, Simone Camera, Lorena Jacques, Melissa de, Sapolnik, Roberto, Lan Jae, Claudia Mei, and Koliski, Adriana

Published
2023
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4. NR3C1 gene methylation and cortisol levels in preterm and healthy full-term infants in the first 3 months of life.

Author

Chalfun, Georgia, Araújo Brasil, Aline de, Paravidino, Vitor Barreto, Soares-Lima, Sheila Coelho, Souza Almeida Lopes, Monique de, Santos Salú, Margarida dos, Barbosa E dos Santos, Paulo Victor, P da Cunha Trompiere, Ana Carolina, Vieira Milone, Leo Travassos, Rodrigues-Santos, Gustavo, Genuíno de Oliveira, Mariana Barros, Robaina, Jaqueline Rodrigues, Lima-Setta, Fernanda, Reis, Marcelo Martins, Ledo Alves da Cunha, Antônio José, Prata-Barbosa, Arnaldo, and de Magalhães-Barbosa, Maria Clara

Published
2022
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