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We describe three cases, in whom DSM-III-R bulimia nervosa developed subsequent to a thyroid disorder. Neither patient previously had had any eating pathology. Marked weight fluctuations occurred during the pretreatment phase and during treatment of the thyroid disorder, and seem to have been an important trigger for the patients' eating disorder. One patient with hypothyroidism abused her prescribed thyroxine in order to induce weight loss.

We report a fully quantitative spectroscopy imaging instrument for wide area detection of early cancer (dysplasia). This instrument provides quantitative maps of tissue biochemistry and morphology, making it a potentially powerful surveillance tool for objective early cancer detection. We describe the design, construction, calibration, and first clinical application of this new system. We demonstrate its accuracy using physical tissue models. We validate its diagnostic ability on a resected colon adenoma, and demonstrate feasibility of in vivo imaging in the oral cavity.

We have developed a quantitative spectroscopic imaging (QSI) system for detecting early cancer. Its effectiveness is demonstrated with ex vivo human colonic mucosa. In addition, clinical data is acquired from the ventral tongue.