Search

Your search keyword '"Georgakakos, Vasileios N."' showing total 9 results
Start Over Author "Georgakakos, Vasileios N."
9 results on '"Georgakakos, Vasileios N."'

3. Jumping translocations in hematological malignancies: a cytogenetic study of five cases

Author

Mancila, Kalliopi N. Georgakakos, Vasileios N. Stavropoulou, Chryssa Spyridonidis, Alexandros Angelopoulou, Maria K. and Vlachadami, Ioanna Katsigiannis, Andreas Roussou, Paraskevi and Pantelias, Gabriel E. Sambani, Constantina

Subjects
hemic and lymphatic diseases
Abstract

Jumping translocations (JT) are rare cytogenetic aberrations in hematological malignancies that include unbalanced translocations involving a donor chromosome arm or chromosome segment that has fused to two or more different recipient chromosomes in different cell lines. We report five cases associated with different hematologic disorders and JT to contribute to the investigation of the origin, pathogenesis, and clinical significance of JT These cases involve JT of 1q in a ease of acute myeloblastic leukemia (AML)-M1, a case of Burkitt lymphoma, and a case of BCR/ABL-positive acute lymphoblastic leukemia, as well as a JT of 13q in a case of AML-M5, and a JT of 11q segment in a case of undifferentiated leukemia. TO Our knowledge, with regard to hematologic malignancies, this study presents the first case of JT associated with AML-M1, the first case of JT involving 13q as a donor chromosome, and the first report of JT involving a segment of 11q containing two copies of the MLL gene, jumping on to two recipient chromosomes in each cell line and resulting in six copies of the MLL gene. Our investigation suggests that JT may not contribute to the pathogenesis but rather to the progression of the disease, and it demonstrates that chromosome band 1q10 as a breakpoint of the donor chromosome 1q is also implicated in AML, not. only in multiple myeloma as it has been known until now. (C) 2008 Elsevier Inc. All rights reserved.

Published
2008

6. The C609T inborn polymorphism in NAD(P)H:quinone oxidoreductase 1 is associated with susceptibility to multiple sclerosis and affects the risk of development of the primary progressive form of the disease

Author

Stavropoulou, Chrysa, primary, Zachaki, Sophia, additional, Alexoudi, Athanasia, additional, Chatzi, Ioanna, additional, Georgakakos, Vasileios N., additional, Terzoudi, Georgia I., additional, Pantelias, Gabriel E., additional, Karageorgiou, Clementine E., additional, and Sambani, Constantina, additional

Published
2011
Full Text
View/download PDF

9. The C609T inborn polymorphism in NAD(P)H:quinone oxidoreductase 1 is associated with susceptibility to multiple sclerosis and affects the risk of development of the primary progressive form of the disease

Author

Stavropoulou, Chrysa, Zachaki, Sophia, Alexoudi, Athanasia, Chatzi, Ioanna, Georgakakos, Vasileios N., Terzoudi, Georgia I., Pantelias, Gabriel E., Karageorgiou, Clementine E., and Sambani, Constantina

Subjects
*OXIDOREDUCTASES, *MULTIPLE sclerosis, *DISEASE progression, *DETOXIFICATION (Alternative medicine), *DISEASE susceptibility, *FREE radicals, *OXIDATIVE stress
Abstract

Abstract: Oxidative stress plays a pivotal role in the pathogenesis of multiple sclerosis (MS). Inactivating polymorphisms of genes encoding detoxification enzymes, such as NAD(P)H:quinone oxidoreductase 1 (NQO1), could influence susceptibility to MS. To test this hypothesis we performed a case–control study in which we compared the distribution of NQO1 genotypes between 231 MS patients and 380 controls, using both PCR–RFLP and real-time PCR assays. Correlations with MS clinical subtype classification and gender were also evaluated. A significantly higher frequency of the homozygous (T/T) and heterozygous (C/T) NQO1 C609T variant genotypes was observed among MS patients compared to controls (P =0.01), with MS patients showing a 1.5-fold increased risk of carrying at least one variant T allele (P =0.009). Interestingly, patients belonging to the primary progressive subgroup exhibited a significantly higher incidence of the heterozygous C/T variant genotype, compared to the other forms of MS (P =0.019). There was no correlation of the NQO1 polymorphism with gender. These results provide the first evidence for a pathogenetic role for the NQO1 C609T polymorphism in MS susceptibility and suggest a possible role for the NQO1 genetic background in the development of primary progressive MS. [Copyright &y& Elsevier]

Published
2011
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results