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2. DNA-sensing inflammasomes cause recurrent atherosclerotic stroke

Author

Cao, Jiayu, Roth, Stefan, Zhang, Sijia, Kopczak, Anna, Mami, Samira, Asare, Yaw, Georgakis, Marios K., Messerer, Denise, Horn, Amit, Shemer, Ruth, Jacqmarcq, Charlene, Picot, Audrey, Green, Jack P., Schlegl, Christina, Li, Xinghai, Tomas, Lukas, Dutsch, Alexander, Liman, Thomas G., Endres, Matthias, Wernsdorf, Saskia R., Fürle, Christina, Carofiglio, Olga, Zhu, Jie, Brough, David, Hornung, Veit, Dichgans, Martin, Vivien, Denis, Schulz, Christian, Dor, Yuval, Tiedt, Steffen, Sager, Hendrik B., Grosse, Gerrit M., and Liesz, Arthur

Published
2024
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4. KCNA2 IgG autoimmunity in neuropsychiatric diseases

Author

Arlt, Friederike A., Miske, Ramona, Machule, Marie-Luise, Broegger Christensen, Peter, Mindorf, Swantje, Teegen, Bianca, Borowski, Kathrin, Buthut, Maria, Rößling, Rosa, Sánchez-Sendín, Elisa, van Hoof, Scott, Cordero-Gómez, César, Bünger, Isabel, Radbruch, Helena, Kraft, Andrea, Ayzenberg, Ilya, Klausewitz, Jaqueline, Hansen, Niels, Timäus, Charles, Körtvelyessy, Peter, Postert, Thomas, Baur-Seack, Kirsten, Rost, Constanze, Brunkhorst, Robert, Doppler, Kathrin, Haigis, Niklas, Hamann, Gerhard, Kunze, Albrecht, Stützer, Alexandra, Maschke, Matthias, Melzer, Nico, Rosenow, Felix, Siebenbrodt, Kai, Stenør, Christian, Dichgans, Martin, Georgakis, Marios K., Fang, Rong, Petzold, Gabor C., Görtler, Michael, Zerr, Inga, Wunderlich, Silke, Mihaljevic, Ivan, Turko, Paul, Schmidt Ettrup, Marianne, Buchholz, Emilie, Foverskov Rasmussen, Helle, Nasouti, Mahoor, Talucci, Ivan, Maric, Hans M., Heinemann, Stefan H., Endres, Matthias, Komorowski, Lars, and Prüss, Harald

Published
2024
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6. Proteogenomic Data Integration Reveals CXCL10 as a Potentially Downstream Causal Mediator for IL-6 Signaling on Atherosclerosis

Author

Prapiadou, Savvina, Živković, Luka, Thorand, Barbara, George, Marc J., van der Laan, Sander W., Malik, Rainer, Herder, Christian, Koenig, Wolfgang, Ueland, Thor, Kleveland, Ola, Aukrust, Pål, Gullestad, Lars, Bernhagen, Jürgen, Pasterkamp, Gerard, Peters, Annette, Hingorani, Aroon D., Rosand, Jonathan, Dichgans, Martin, Anderson, Christopher D., and Georgakis, Marios K.

Published
2024
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7. Proteogenomic Data Integration Reveals CXCL10 as a Potentially Downstream Causal Mediator for IL-6 Signaling on Atherosclerosis

Author

Prapiadou, Savvina, Živković, Luka, Thorand, Barbara, George, Marc J., van der Laan, Sander W., Malik, Rainer, Herder, Christian, Koenig, Wolfgang, Ueland, Thor, Kleveland, Ola, Aukrust, Pål, Gullestad, Lars, Bernhagen, Jürgen, Pasterkamp, Gerard, Peters, Annette, Hingorani, Aroon D., Rosand, Jonathan, Dichgans, Martin, Anderson, Christopher D., and Georgakis, Marios K.

Published
2023
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9. Stroke genetics informs drug discovery and risk prediction across ancestries

Author

Mishra, Aniket, Malik, Rainer, Hachiya, Tsuyoshi, Jürgenson, Tuuli, Namba, Shinichi, Posner, Daniel C., Kamanu, Frederick K., Koido, Masaru, Le Grand, Quentin, Shi, Mingyang, He, Yunye, Georgakis, Marios K., Caro, Ilana, Krebs, Kristi, Liaw, Yi-Ching, Vaura, Felix C., Lin, Kuang, Winsvold, Bendik Slagsvold, Srinivasasainagendra, Vinodh, Parodi, Livia, Bae, Hee-Joon, Chauhan, Ganesh, Chong, Michael R., Tomppo, Liisa, Akinyemi, Rufus, Roshchupkin, Gennady V., Habib, Naomi, Jee, Yon Ho, Thomassen, Jesper Qvist, Abedi, Vida, Cárcel-Márquez, Jara, Nygaard, Marianne, Leonard, Hampton L., Yang, Chaojie, Yonova-Doing, Ekaterina, Knol, Maria J., Lewis, Adam J., Judy, Renae L., Ago, Tetsuro, Amouyel, Philippe, Armstrong, Nicole D., Bakker, Mark K., Bartz, Traci M., Bennett, David A., Bis, Joshua C., Bordes, Constance, Børte, Sigrid, Cain, Anael, Ridker, Paul M., Cho, Kelly, Chen, Zhengming, Cruchaga, Carlos, Cole, John W., de Jager, Phil L., de Cid, Rafael, Endres, Matthias, Ferreira, Leslie E., Geerlings, Mirjam I., Gasca, Natalie C., Gudnason, Vilmundur, Hata, Jun, He, Jing, Heath, Alicia K., Ho, Yuk-Lam, Havulinna, Aki S., Hopewell, Jemma C., Hyacinth, Hyacinth I., Inouye, Michael, Jacob, Mina A., Jeon, Christina E., Jern, Christina, Kamouchi, Masahiro, Keene, Keith L., Kitazono, Takanari, Kittner, Steven J., Konuma, Takahiro, Kumar, Amit, Lacaze, Paul, Launer, Lenore J., Lee, Keon-Joo, Lepik, Kaido, Li, Jiang, Li, Liming, Manichaikul, Ani, Markus, Hugh S., Marston, Nicholas A., Meitinger, Thomas, Mitchell, Braxton D., Montellano, Felipe A., Morisaki, Takayuki, Mosley, Thomas H., Nalls, Mike A., Nordestgaard, Børge G., O’Donnell, Martin J., Okada, Yukinori, Onland-Moret, N. Charlotte, Ovbiagele, Bruce, Peters, Annette, Psaty, Bruce M., Rich, Stephen S., Rosand, Jonathan, Sabatine, Marc S., Sacco, Ralph L., Saleheen, Danish, Sandset, Else Charlotte, Salomaa, Veikko, Sargurupremraj, Muralidharan, Sasaki, Makoto, Satizabal, Claudia L., Schmidt, Carsten O., Shimizu, Atsushi, Smith, Nicholas L., Sloane, Kelly L., Sutoh, Yoichi, Sun, Yan V., Tanno, Kozo, Tiedt, Steffen, Tatlisumak, Turgut, Torres-Aguila, Nuria P., Tiwari, Hemant K., Trégouët, David-Alexandre, Trompet, Stella, Tuladhar, Anil Man, Tybjærg-Hansen, Anne, van Vugt, Marion, Vibo, Riina, Verma, Shefali S., Wiggins, Kerri L., Wennberg, Patrik, Woo, Daniel, Wilson, Peter W. F., Xu, Huichun, Yang, Qiong, Yoon, Kyungheon, Millwood, Iona Y., Gieger, Christian, Ninomiya, Toshiharu, Grabe, Hans J., Jukema, J. Wouter, Rissanen, Ina L., Strbian, Daniel, Kim, Young Jin, Chen, Pei-Hsin, Mayerhofer, Ernst, Howson, Joanna M. M., Irvin, Marguerite R., Adams, Hieab, Wassertheil-Smoller, Sylvia, Christensen, Kaare, Ikram, Mohammad A., Rundek, Tatjana, Worrall, Bradford B., Lathrop, G. Mark, Riaz, Moeen, Simonsick, Eleanor M., Kõrv, Janika, França, Paulo H. C., Zand, Ramin, Prasad, Kameshwar, Frikke-Schmidt, Ruth, de Leeuw, Frank-Erik, Liman, Thomas, Haeusler, Karl Georg, Ruigrok, Ynte M., Heuschmann, Peter Ulrich, Longstreth, W. T., Jung, Keum Ji, Bastarache, Lisa, Paré, Guillaume, Damrauer, Scott M., Chasman, Daniel I., Rotter, Jerome I., Anderson, Christopher D., Zwart, John-Anker, Niiranen, Teemu J., Fornage, Myriam, Liaw, Yung-Po, Seshadri, Sudha, Fernández-Cadenas, Israel, Walters, Robin G., Ruff, Christian T., Owolabi, Mayowa O., Huffman, Jennifer E., Milani, Lili, Kamatani, Yoichiro, Dichgans, Martin, and Debette, Stephanie

Published
2022
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10. The Meta VCI Map consortium for meta‐analyses on strategic lesion locations for vascular cognitive impairment using lesion‐symptom mapping: Design and multicenter pilot study

Author

Weaver, Nick A, Zhao, Lei, Biesbroek, J Matthijs, Kuijf, Hugo J, Aben, Hugo P, Bae, Hee‐Joon, Caballero, Miguel ÁA, Chappell, Francesca M, Chen, Christopher PLH, Dichgans, Martin, Duering, Marco, Georgakis, Marios K, van der Giessen, Ruben S, Gyanwali, Bibek, Hamilton, Olivia KL, Hilal, Saima, Hofe, Elise M vom, de Kort, Paul LM, Koudstaal, Peter J, Lam, Bonnie YK, Lim, Jae‐Sung, Makin, Stephen DJ, Mok, Vincent CT, Shi, Lin, Hernández, Maria C Valdés, Venketasubramanian, Narayanaswamy, Wardlaw, Joanna M, Wollenweber, Frank A, Wong, Adrian, Xin, Xu, consortium, Meta VCI Map, DeCarli, C, Fletcher, EA, Maillard, P, Barnes, J, Sudre, CH, Schott, JM, Ikram, MA, Papma, JM, Steketee, RME, Vernooij, MW, Bordet, R, Lopes, R, Huang, C‐W, Frayne, R, McCreary, CR, Smith, EE, group, Calgary Normative Study, Backes, W, Köhler, S, van Oostenbrugge, RJ, Staals, J, Verhey, F, Cheng, CY, Kalaria, RN, Werring, D, Hsu, JL, Huang, K‐L, van der Grond, J, Jukema, JW, van der Mast, RC, Nijboer, TCW, group, Framingham Heart Study, Yu, K‐H, group, The Dutch Parelsnoer Institute–Neurodegenerative diseases, Schmidt, R, Pirpamer, L, MacIntosh, BJ, Robertson, AD, de Leeuw, F‐E, Tuladhar, AM, Chaturvedi, N, Tillin, T, Brodaty, H, Sachdev, P, group, TABASCO, Barkhof, F, van der Flier, WM, Kappelle, LJ, and Biessels, Geert Jan

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Biomedical Imaging, Atherosclerosis, Clinical Research, Brain Disorders, Acquired Cognitive Impairment, Stroke, Neurosciences, Meta VCI Map consortium, Cerebrovascular disease, Consortium, Data harmonization, Lesion location, Lesion-symptom mapping, Small vessel disease, Support vector regression, Vascular cognitive impairment, Genetics, Biological psychology
Abstract

IntroductionThe Meta VCI Map consortium performs meta-analyses on strategic lesion locations for vascular cognitive impairment using lesion-symptom mapping. Integration of data from different cohorts will increase sample sizes, to improve brain lesion coverage and support comprehensive lesion-symptom mapping studies.MethodsCohorts with available imaging on white matter hyperintensities or infarcts and cognitive testing were invited. We performed a pilot study to test the feasibility of multicenter data processing and analysis and determine the benefits to lesion coverage.ResultsForty-seven groups have joined Meta VCI Map (stroke n = 7800 patients; memory clinic n = 4900; population-based n = 14,400). The pilot study (six ischemic stroke cohorts, n = 878) demonstrated feasibility of multicenter data integration (computed tomography/magnetic resonance imaging) and achieved marked improvement of lesion coverage.DiscussionMeta VCI Map will provide new insights into the relevance of vascular lesion location for cognitive dysfunction. After the successful pilot study, further projects are being prepared. Other investigators are welcome to join.

Published
2019

16. Advanced parental age as risk factor for childhood acute lymphoblastic leukemia: results from studies of the Childhood Leukemia International Consortium

Author

Petridou, Eleni Th, Georgakis, Marios K, Erdmann, Friederike, Ma, Xiaomei, Heck, Julia E, Auvinen, Anssi, Mueller, Beth A, Spector, Logan G, Roman, Eve, Metayer, Catherine, Magnani, Corrado, Pombo-de-Oliveira, Maria S, Ezzat, Sameera, Scheurer, Michael E, Mora, Ana Maria, Dockerty, John D, Hansen, Johnni, Kang, Alice Y, Wang, Rong, Doody, David R, Kane, Eleanor, Rashed, Waffa M, Dessypris, Nick, Schüz, Joachim, Infante-Rivard, Claire, and Skalkidou, Alkistis

Subjects
Epidemiology, Public Health, Health Sciences, Rare Diseases, Pediatric, Cancer, Clinical Research, Hematology, Pediatric Research Initiative, Childhood Leukemia, Pediatric Cancer, Reproductive health and childbirth, Case-Control Studies, Child, Child, Preschool, Female, Humans, Infant, Infant, Newborn, Male, Maternal Age, Parents, Paternal Age, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Pregnancy, Prenatal Exposure Delayed Effects, Risk Factors, Maternal age, Paternal age, Acute lymphoblastic leukemia, Childhood, Risk factors, Case-control, Case–control, Public Health and Health Services
Abstract

Advanced parental age has been associated with adverse health effects in the offspring including childhood (0-14 years) acute lymphoblastic leukemia (ALL), as reported in our meta-analysis of published studies. We aimed to further explore the association using primary data from 16 studies participating in the Childhood Leukemia International Consortium. Data were contributed by 11 case-control (CC) studies (7919 cases and 12,942 controls recruited via interviews) and five nested case-control (NCC) studies (8801 cases and 29,690 controls identified through record linkage of population-based health registries) with variable enrollment periods (1968-2015). Five-year paternal and maternal age increments were introduced in two meta-analyses by study design using adjusted odds ratios (OR) derived from each study. Increased paternal age was associated with greater ALL risk in the offspring (ORCC 1.05, 95% CI 1.00-1.11; ORNCC 1.04, 95% CI 1.01-1.07). A similar positive association with advanced maternal age was observed only in the NCC results (ORCC 0.99, 95% CI 0.91-1.07, heterogeneity I2 = 58%, p = 0.002; ORNCC 1.05, 95% CI 1.01-1.08). The positive association between parental age and risk of ALL was most marked among children aged 1-5 years and remained unchanged following mutual adjustment for the collinear effect of the paternal and maternal age variables; analyses of the relatively small numbers of discordant paternal-maternal age pairs were not fully enlightening. Our results strengthen the evidence that advanced parental age is associated with increased childhood ALL risk; collinearity of maternal with paternal age complicates causal interpretation. Employing datasets with cytogenetic information may further elucidate involvement of each parental component and clarify underlying mechanisms.

Published
2018

19. Proteogenomic Data Integration Reveals CXCL10 as a Potentially Downstream Causal Mediator for IL-6 Signaling on Atherosclerosis

Author

CDL Onderzoek Pasterkamp, Circulatory Health, Centraal Diagnostisch Laboratorium, Prapiadou, Savvina, Živković, Luka, Thorand, Barbara, George, Marc J, van der Laan, Sander W, Malik, Rainer, Herder, Christian, Koenig, Wolfgang, Ueland, Thor, Kleveland, Ola, Aukrust, Pål, Gullestad, Lars, Bernhagen, Jürgen, Pasterkamp, Gerard, Peters, Annette, Hingorani, Aroon D, Rosand, Jonathan, Dichgans, Martin, Anderson, Christopher D, Georgakis, Marios K, CDL Onderzoek Pasterkamp, Circulatory Health, Centraal Diagnostisch Laboratorium, Prapiadou, Savvina, Živković, Luka, Thorand, Barbara, George, Marc J, van der Laan, Sander W, Malik, Rainer, Herder, Christian, Koenig, Wolfgang, Ueland, Thor, Kleveland, Ola, Aukrust, Pål, Gullestad, Lars, Bernhagen, Jürgen, Pasterkamp, Gerard, Peters, Annette, Hingorani, Aroon D, Rosand, Jonathan, Dichgans, Martin, Anderson, Christopher D, and Georgakis, Marios K

Published
2024

20. Mendelian Randomization Applied to Neurology

Author

Gagnon, Eloi, Daghlas, Iyas, Zagkos, Loukas, Sargurupremraj, Muralidharan, Georgakis, Marios K., Anderson, Christopher D., Cronje, Helene T., Burgess, Stephen, Arsenault, Benoit J., Gill, Dipender, Gagnon, Eloi, Daghlas, Iyas, Zagkos, Loukas, Sargurupremraj, Muralidharan, Georgakis, Marios K., Anderson, Christopher D., Cronje, Helene T., Burgess, Stephen, Arsenault, Benoit J., and Gill, Dipender

Abstract

The Mendelian randomization (MR) paradigm allows for causal inferences to be drawn using genetic data. In recent years, the expansion of well-powered publicly available genetic association data related to phenotypes such as brain tissue gene expression, brain imaging, and neurologic diseases offers exciting opportunities for the application of MR in the field of neurology. In this review, we discuss the basic principles of MR, its myriad applications to research in neurology, and potential pitfalls of injudicious applications. Throughout, we provide examples where MR-informed findings have shed light on long-standing epidemiologic controversies, provided insights into the pathophysiology of neurologic conditions, prioritized drug targets, and informed drug repurposing opportunities. With the ever-expanding availability of genome-wide association data, we project MR to become a key driver of progress in the field of neurology. It is therefore paramount that academics and clinicians within the field are familiar with the approach., The Mendelian randomization (MR) paradigm allows for causal inferences to be drawn using genetic data. In recent years, the expansion of well-powered publicly available genetic association data related to phenotypes such as brain tissue gene expression, brain imaging, and neurologic diseases offers exciting opportunities for the application of MR in the field of neurology. In this review, we discuss the basic principles of MR, its myriad applications to research in neurology, and potential pitfalls of injudicious applications. Throughout, we provide examples where MR-informed findings have shed light on long-standing epidemiologic controversies, provided insights into the pathophysiology of neurologic conditions, prioritized drug targets, and informed drug repurposing opportunities. With the ever-expanding availability of genome-wide association data, we project MR to become a key driver of progress in the field of neurology. It is therefore paramount that academics and clinicians within the field are familiar with the approach.

Published
2024

22. Translating Anti-Inflammatory Strategies for Atherosclerosis: Deep Phenotyping, Next-Generation Drug Targets, and Precision Medicine.

Author

Asare, Yaw and Georgakis, Marios K.

Subjects
*REGULATORY T cells, *MAJOR adverse cardiovascular events, *ATHEROSCLEROTIC plaque, *CARDIOVASCULAR system, *POSITRON emission tomography, *METABOLOMICS
Abstract

Atherosclerosis, a condition characterized by inflammation in the arteries, is the main cause of cardiovascular disease (CVD), including heart attacks and strokes. While current treatments focus on lowering cholesterol levels, new anti-inflammatory strategies are being explored as potential therapies for atherosclerosis. These strategies involve targeting the immune system's role in atherosclerosis and have shown promise in reducing CVD risk. However, challenges such as the risk of infections and individual variability in drug response need to be addressed. Advances in technologies like single-cell transcriptomics and PET imaging are aiding in the deeper understanding of the immune landscape of atherosclerosis and the identification of potential drug targets and biomarkers. These developments may lead to personalized therapies for atherosclerosis in the future. [Extracted from the article]

Published
2024
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23. Genetically proxied IL‐6 signaling and risk of Alzheimer's disease and lobar intracerebral hemorrhage: A drug target Mendelian randomization study.

Author

Myserlis, Evangelos Pavlos, Ray, Anushree, Anderson, Christopher D., and Georgakis, Marios K.

Subjects
DISEASE risk factors, BLOOD proteins, ALZHEIMER'S disease, CEREBRAL hemorrhage, CEREBROSPINAL fluid
Abstract

INTRODUCTION: Evidence suggests that higher C‐reactive protein (CRP) is associated with lower risk of Alzheimer's disease (AD) and lobar intracerebral hemorrhage (ICH). Whether interleukin (IL)‐6 signaling, an active pharmacological target upstream of CRP, is associated with these amyloid‐related pathologies remains unknown. METHODS: We used 26 CRP‐lowering variants near the IL‐6 receptor gene to perform Mendelian randomization analyses for AD (111,326 cases, 677,663 controls) and ICH (1545 cases, 1481 controls). We explored the effect of genetically proxied IL‐6 signaling on serum, cerebrospinal fluid (CSF), and brain proteome (971 individuals). RESULTS: Genetically upregulated IL‐6 receptor‐mediated signaling was associated with lower risk of AD (OR per increment in serum logCRP levels: 0.87, 95% CI: 0.79–0.95) and lobar ICH (OR: 0.27, 95% CI: 0.09–0.89). We also found associations with 312, 77, and 79 brain, CSF, and plasma proteins, respectively, some of which were previously implicated in amyloid‐clearing mechanisms. DISCUSSION: Genetic data support that CRP‐lowering through variation in the gene encoding IL‐6 receptor may be associated with amyloid‐related outcomes. Highlights: Genetic variants proxying IL‐6 inhibition are associated with AD and lobar ICH risk.The variants are also associated with amyloid clearing‐related proteomic changes.Whether pharmacologic IL‐6 inhibition is linked to AD or lobar ICH merits further study. [ABSTRACT FROM AUTHOR]

Published
2024
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25. Mendelian Randomization Applied to Neurology

Author

Gagnon, Eloi, primary, Daghlas, Iyas, additional, Zagkos, Loukas, additional, Sargurupremraj, Muralidharan, additional, Georgakis, Marios K., additional, Anderson, Christopher D., additional, Cronje, Helene T., additional, Burgess, Stephen, additional, Arsenault, Benoit J., additional, and Gill, Dipender, additional

Published
2024
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27. Publisher Correction: Stroke genetics informs drug discovery and risk prediction across ancestries

Author

Mishra, Aniket, Malik, Rainer, Hachiya, Tsuyoshi, Jürgenson, Tuuli, Namba, Shinichi, Posner, Daniel C., Kamanu, Frederick K., Koido, Masaru, Le Grand, Quentin, Shi, Mingyang, He, Yunye, Georgakis, Marios K., Caro, Ilana, Krebs, Kristi, Liaw, Yi-Ching, Vaura, Felix C., Lin, Kuang, Winsvold, Bendik Slagsvold, Srinivasasainagendra, Vinodh, Parodi, Livia, Bae, Hee-Joon, Chauhan, Ganesh, Chong, Michael R., Tomppo, Liisa, Akinyemi, Rufus, Roshchupkin, Gennady V., Habib, Naomi, Jee, Yon Ho, Thomassen, Jesper Qvist, Abedi, Vida, Cárcel-Márquez, Jara, Nygaard, Marianne, Leonard, Hampton L., Yang, Chaojie, Yonova-Doing, Ekaterina, Knol, Maria J., Lewis, Adam J., Judy, Renae L., Ago, Tetsuro, Amouyel, Philippe, Armstrong, Nicole D., Bakker, Mark K., Bartz, Traci M., Bennett, David A., Bis, Joshua C., Bordes, Constance, Børte, Sigrid, Cain, Anael, Ridker, Paul M., Cho, Kelly, Chen, Zhengming, Cruchaga, Carlos, Cole, John W., de Jager, Phil L., de Cid, Rafael, Endres, Matthias, Ferreira, Leslie E., Geerlings, Mirjam I., Gasca, Natalie C., Gudnason, Vilmundur, Hata, Jun, He, Jing, Heath, Alicia K., Ho, Yuk-Lam, Havulinna, Aki S., Hopewell, Jemma C., Hyacinth, Hyacinth I., Inouye, Michael, Jacob, Mina A., Jeon, Christina E., Jern, Christina, Kamouchi, Masahiro, Keene, Keith L., Kitazono, Takanari, Kittner, Steven J., Konuma, Takahiro, Kumar, Amit, Lacaze, Paul, Launer, Lenore J., Lee, Keon-Joo, Lepik, Kaido, Li, Jiang, Li, Liming, Manichaikul, Ani, Markus, Hugh S., Marston, Nicholas A., Meitinger, Thomas, Mitchell, Braxton D., Montellano, Felipe A., Morisaki, Takayuki, Mosley, Thomas H., Nalls, Mike A., Nordestgaard, Børge G., O’Donnell, Martin J., Okada, Yukinori, Onland-Moret, N. Charlotte, Ovbiagele, Bruce, Peters, Annette, Psaty, Bruce M., Rich, Stephen S., Rosand, Jonathan, Sabatine, Marc S., Sacco, Ralph L., Saleheen, Danish, Sandset, Else Charlotte, Salomaa, Veikko, Sargurupremraj, Muralidharan, Sasaki, Makoto, Satizabal, Claudia L., Schmidt, Carsten O., Shimizu, Atsushi, Smith, Nicholas L., Sloane, Kelly L., Sutoh, Yoichi, Sun, Yan V., Tanno, Kozo, Tiedt, Steffen, Tatlisumak, Turgut, Torres-Aguila, Nuria P., Tiwari, Hemant K., Trégouët, David-Alexandre, Trompet, Stella, Tuladhar, Anil Man, Tybjærg-Hansen, Anne, van Vugt, Marion, Vibo, Riina, Verma, Shefali S., Wiggins, Kerri L., Wennberg, Patrik, Woo, Daniel, Wilson, Peter W. F., Xu, Huichun, Yang, Qiong, Yoon, Kyungheon, Millwood, Iona Y., Gieger, Christian, Ninomiya, Toshiharu, Grabe, Hans J., Jukema, J. Wouter, Rissanen, Ina L., Strbian, Daniel, Kim, Young Jin, Chen, Pei-Hsin, Mayerhofer, Ernst, Howson, Joanna M. M., Irvin, Marguerite R., Adams, Hieab, Wassertheil-Smoller, Sylvia, Christensen, Kaare, Ikram, Mohammad A., Rundek, Tatjana, Worrall, Bradford B., Lathrop, G. Mark, Riaz, Moeen, Simonsick, Eleanor M., Kõrv, Janika, França, Paulo H. C., Zand, Ramin, Prasad, Kameshwar, Frikke-Schmidt, Ruth, de Leeuw, Frank-Erik, Liman, Thomas, Haeusler, Karl Georg, Ruigrok, Ynte M., Heuschmann, Peter Ulrich, Longstreth, W. T., Jung, Keum Ji, Bastarache, Lisa, Paré, Guillaume, Damrauer, Scott M., Chasman, Daniel I., Rotter, Jerome I., Anderson, Christopher D., Zwart, John-Anker, Niiranen, Teemu J., Fornage, Myriam, Liaw, Yung-Po, Seshadri, Sudha, Fernández-Cadenas, Israel, Walters, Robin G., Ruff, Christian T., Owolabi, Mayowa O., Huffman, Jennifer E., Milani, Lili, Kamatani, Yoichiro, Dichgans, Martin, and Debette, Stephanie

Published
2022
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28. Clinical presentation of young people (10–24 years old) with brain tumors: results from the international MOBI-Kids study

Author

Zumel-Marne, Angela, Kundi, Michael, Castaño-Vinyals, Gemma, Alguacil, Juan, Petridou, Eleni Th, Georgakis, Marios K., Morales-Suárez-Varela, Maria, Sadetzki, Siegal, Piro, Sara, Nagrani, Rajini, Filippini, Graziella, Hutter, Hans-Peter, Dikshit, Rajesh, Woehrer, Adelheid, Maule, Milena, Weinmann, Tobias, Krewski, Daniel, ′t Mannetje, Andrea, Momoli, Franco, Lacour, Brigitte, Mattioli, Stefano, Spinelli, John J., Ritvo, Paul, Remen, Thomas, Kojimahara, Noriko, Eng, Amanda, Thurston, Angela, Lim, Hyungryul, Ha, Mina, Yamaguchi, Naohito, Mohipp, Charmaine, Bouka, Evdoxia, Eastman, Chelsea, Vermeulen, Roel, Kromhout, Hans, and Cardis, Elisabeth

Published
2020
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30. The Meta VCI Map consortium for meta-analyses on strategic lesion locations for vascular cognitive impairment using lesion-symptom mapping: Design and multicenter pilot study

Author

DeCarli, C., Fletcher, E.A., Maillard, P., Barnes, J., Sudre, C.H., Schott, J.M., Ikram, M.A., Papma, J.M., Steketee, R.M.E., Vernooij, M.W., Bordet, R., Lopes, R., Huang, C.-W., Frayne, R., McCreary, C.R., Smith, E.E., Backes, W., Köhler, S., van Oostenbrugge, R.J., Staals, J., Verhey, F., Cheng, C.Y., Kalaria, R.N., Werring, D., Hsu, J.L., Huang, K.-L., van der Grond, J., Jukema, J.W., van der Mast, R.C., Nijboer, T.C.W., Yu, K.-H., Schmidt, R., Pirpamer, L., MacIntosh, B.J., Robertson, A.D., de Leeuw, F.-E., Tuladhar, A.M., Chaturvedi, N., Tillin, T., Brodaty, H., Sachdev, P., Barkhof, F., van der Flier, W.M., Kappelle, L.J., Weaver, Nick A., Zhao, Lei, Biesbroek, J. Matthijs, Kuijf, Hugo J., Aben, Hugo P., Bae, Hee-Joon, Caballero, Miguel Á.A., Chappell, Francesca M., Chen, Christopher P.L.H., Dichgans, Martin, Duering, Marco, Georgakis, Marios K., van der Giessen, Ruben S., Gyanwali, Bibek, Hamilton, Olivia K.L., Hilal, Saima, vom Hofe, Elise M., de Kort, Paul L.M., Koudstaal, Peter J., Lam, Bonnie Y.K., Lim, Jae-Sung, Makin, Stephen D.J., Mok, Vincent C.T., Shi, Lin, Valdés Hernández, Maria C., Venketasubramanian, Narayanaswamy, Wardlaw, Joanna M., Wollenweber, Frank A., Wong, Adrian, Xin, Xu, and Biessels, Geert Jan

Published
2019
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34. Perinatal and early life risk factors for childhood brain tumors: Is instrument-assisted delivery associated with higher risk?

Author

Bourgioti, Charis, Dana, Helen, Papadopoulos, Savvas, Sfakianos, Georgios, Themistocleous, Marios, Stefanaki, Kalliopi, Strantzia, Katerina, Zountsas, Basilios, Vakis, Antonios, Manolitsi, Katerina, Kelekis, Nikolaos, Papathanasiou, Mathilda, Gkantaifi, Areti, Koutzoglou, Michalis, Koletsa, Triantafyllia, Nikas, Ioannis, Zacharoulis, Stergios, Prassopoulos, Panagiotis, Orfanides, George, Panagiotis, Primikiris, Zerris, Vasilios, Friehs, Gerhard, Vyziotis, Alex, Patsouris, Eustratios, Georgakis, Marios K., Dessypris, Nick, Papadakis, Vassilios, Tragiannidis, Athanasios, Bouka, Evdoxia, Hatzipantelis, Emmanuel, Moschovi, Maria, Papakonstantinou, Evgenia, Polychronopoulou, Sophia, Sgouros, Spyridon, Stiakaki, Eftichia, Pourtsidis, Apostolos, Psaltopoulou, Theodora, and Petridou, Eleni Th.

Published
2019
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38. Deep Resequencing of the 1q22 Locus in Non‐Lobar Intracerebral Hemorrhage

Author

Parodi, Livia, primary, Comeau, Mary E., additional, Georgakis, Marios K., additional, Mayerhofer, Ernst, additional, Chung, Jaeyoon, additional, Falcone, Guido J., additional, Malik, Rainer, additional, Demel, Stacie L., additional, Worrall, Bradford B., additional, Koch, Sebastian, additional, Testai, Fernando D., additional, Kittner, Steven J., additional, McCauley, Jacob L., additional, Hall, Christiana E., additional, Mayson, Douglas J., additional, Elkind, Mitchell S.V., additional, James, Michael L., additional, Woo, Daniel, additional, Rosand, Jonathan, additional, Langefeld, Carl D., additional, and Anderson, Christopher D., additional

Published
2023
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42. Persisting inequalities in survival patterns of childhood neuroblastoma in Southern and Eastern Europe and the effect of socio-economic development compared with those of the US

Author

Panagopoulou, Paraskevi, Georgakis, Marios K., Baka, Margarita, Moschovi, Maria, Papadakis, Vassilios, Polychronopoulou, Sophia, Kourti, Maria, Hatzipantelis, Emmanuel, Stiakaki, Eftichia, Dana, Helen, Tragiannidis, Athanasios, Bouka, Evdoxia, Antunes, Luis, Bastos, Joana, Coza, Daniela, Demetriou, Anna, Agius, Domenic, Eser, Sultan, Gheorghiu, Raluca, Šekerija, Mario, Trojanowski, Maciej, Žagar, Tina, Zborovskaya, Anna, Ryzhov, Anton, Dessypris, Nick, Morgenstern, Daniel, and Petridou, Eleni Th

Published
2018
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43. Childhood nephroblastoma in Southern and Eastern Europe and the US: Incidence variations and temporal trends by human development index

Author

Doganis, Dimitrios, Panagopoulou, Paraskevi, Tragiannidis, Athanasios, Georgakis, Marios K., Moschovi, Maria, Polychronopoulou, Sofia, Rigatou, Efthimia, Papakonstantinou, Eugenia, Stiakaki, Eftichia, Dana, Helen, Bouka, Evdoxia, Antunes, Luis, Bastos, Joana, Coza, Daniela, Demetriou, Anna, Agius, Domenic, Eser, Sultan, Ryzhov, Anton, Sekerija, Mario, Trojanowski, Maciej, Zagar, Tina, Zborovskaya, Anna, Perisic, Snezana Zivkovic, Stefanaki, Kalliopi, Dessypris, Nick, and Petridou, Eleni Th.

Published
2018
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47. Carriers of rare damaging CCR2 genetic variants are at lower risk of atherosclerotic disease

Author

Georgakis, Marios K, primary, Malik, Rainer, additional, Hasbani, Natalie R, additional, Shakt, Gabrielle, additional, Morrison, Alanna, additional, Tsao, Noah L, additional, Judy, Renae, additional, Mitchell, Braxton D, additional, Xu, Huichun, additional, Montasser, May E, additional, Do, Ron, additional, Kenny, Eimear, additional, Loos, Ruth J.F., additional, Terry, James G, additional, Carr, John Jeffrey, additional, Bis, Joshua C., additional, Psaty, Bruce M., additional, Longstreth, W T, additional, Young, Kendra, additional, Lutz, Sharon M, additional, Cho, Michael, additional, Broome, Jai, additional, Khan, Alyna T, additional, Wang, Fei Fei, additional, Heard-Costa, Nancy, additional, Seshadri, Sudha, additional, Ramachandran, Vasan, additional, Palmer, Nicholette D., additional, Freedman, Barry I, additional, Bowden, Donald W, additional, Yanek, Lisa R, additional, Kral, Brian G, additional, Becker, Lewis C, additional, Peyser, Patricia A, additional, Bielak, Lawrence F, additional, Ammous, Farah, additional, Carson, April P., additional, Hall, Michael E, additional, Raffield, Laura M, additional, Rich, Steve, additional, Post, Wendy, additional, Tracy, Russell, additional, Taylor, Kent, additional, Guo, Xiuqing, additional, Mahaney, Michael, additional, Curran, Joanne E., additional, Blangero, John, additional, Clarke, Shoa L., additional, Haessler, Jeffrey, additional, Hu, Yao, additional, Assimes, Themistocles L, additional, Kooperberg, Charles, additional, Damrauer, Scott M., additional, Rotter, Jerome, additional, de Vries, Paul S, additional, and Dichgans, Martin, additional

Published
2023
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49. Central nervous system tumours among adolescents and young adults (15–39 years) in Southern and Eastern Europe: Registration improvements reveal higher incidence rates compared to the US

Author

Georgakis, Marios K., Panagopoulou, Paraskevi, Papathoma, Paraskevi, Tragiannidis, Athanasios, Ryzhov, Anton, Zivkovic-Perisic, Snezana, Eser, Sultan, Taraszkiewicz, Łukasz, Sekerija, Mario, Žagar, Tina, Antunes, Luis, Zborovskaya, Anna, Bastos, Joana, Florea, Margareta, Coza, Daniela, Demetriou, Anna, Agius, Domenic, Strahinja, Rajko M., Sfakianos, Georgios, Nikas, Ioannis, Kosmidis, Sofia, Razis, Evangelia, Pourtsidis, Apostolos, Kantzanou, Maria, Dessypris, Nick, and Petridou, Eleni Th.

Published
2017
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