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4,140 results on '"George, Jacob"'

4. A global survey on the use of the international classification of diseases codes for metabolic dysfunction-associated fatty liver disease

Author

Zhang, Huai, Targher, Giovanni, Byrne, Christopher D., Kim, Seung Up, Wong, Vincent Wai-Sun, Valenti, Luca, Glickman, Myer, Ponce, Jaime, Mantzoros, Christos S., Crespo, Javier, Gronbaek, Henning, Yang, Wah, Eslam, Mohammed, Wong, Robert J., Machado, Mariana Verdelho, Yu, Ming-Lung, Ghanem, Omar M., Okanoue, Takeshi, Liu, Jun-Feng, Lee, Yong-ho, Xu, Xiao-Yuan, Pan, Qiuwei, Sui, Meili, Lonardo, Amedeo, Yilmaz, Yusuf, Zhu, Li-Yong, Moreno, Christophe, Miele, Luca, Lupsor-Platon, Monica, Zhao, Lei, LaMasters, Teresa LeAnn, Gish, Robert G., Zhang, Huijie, Nedelcu, Marius, Chan, Wah Kheong, Xia, Ming-Feng, Bril, Fernando, Shi, Jun-Ping, Datz, Christian, Romeo, Stefano, Sun, Jian, Liu, Dan, Sookoian, Silvia, Mao, Yi-Min, Méndez-Sánchez, Nahum, Wang, Xiao-Yan, Pyrsopoulos, Nikolaos T., Fan, Jian-Gao, Fouad, Yasser, Sun, Dan-Qin, Giannini, Cosimo, Chai, Jin, Xia, Ze-Feng, Jun, Dae Won, Li, Guo-Jing, Treeprasertsuk, Sombat, Li, Ying-Xu, Cheung, Tan To, Zhang, Faming, Goh, George Boon-Bee, Furuhashi, Masato, Seto, Wai-Kay, Huang, Hui, Di Sessa, Anna, Li, Qing-Hong, Cholongitas, Evangelos, Zhang, Le, Silveira, Themis Reverbel, Sebastiani, Giada, Adams, Leon A., Chen, Wei, Qi, Xiaolong, Rankovic, Ivan, De Ledinghen, Victor, Lv, Wen-Jie, Hamaguchi, Masahide, Kassir, Radwan, Müller-Wieland, Dirk, Romero-Gomez, Manuel, Xu, Ying, Xu, Yi-Cong, Chen, Shi-Yao, Kermansaravi, Mohammad, Kuchay, Mohammad Shafi, Lefere, Sander, Parmar, Chetan, Lip, Gregory Y. H., Liu, Chun-Jen, Åberg, Fredrik, Lau, George, George, Jacob, Sarin, Shiv Kumar, Zhou, Jing-Ya, and Zheng, Ming-Hua

Published
2024
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5. Asian Pacific Association for the Study of the Liver clinical practice guidelines on liver transplantation

Author

Kim, Dong-Sik, Yoon, Young-In, Kim, Beom Kyung, Choudhury, Ashok, Kulkarni, Anand, Park, Jun Yong, Kim, Jongman, Sinn, Dong Hyun, Joo, Dong Jin, Choi, YoungRok, Lee, Jeong-Hoon, Choi, Ho Joong, Yoon, Ki Tae, Yim, Sun Young, Park, Cheon-Soo, Kim, Deok-Gie, Lee, Hae Won, Choi, Won-Mook, Chon, Young Eun, Kang, Woo-Hyoung, Rhu, Jinsoo, Lee, Jae Geun, Cho, Yuri, Sung, Pil Soo, Lee, Han Ah, Kim, Ji Hoon, Bae, Si Hyun, Yang, Jin Mo, Suh, Kyung-Suk, Al Mahtab, Mamun, Tan, Soek Siam, Abbas, Zaigham, Shresta, Ananta, Alam, Shahinul, Arora, Anil, Kumar, Ashish, Rathi, Pravin, Bhavani, Ruveena, Panackel, Charles, Lee, Kuei Chuan, Li, Jun, Yu, Ming-Lung, George, Jacob, Tanwandee, Tawesak, Hsieh, Sen-Yung, Yong, Chee Chien, Rela, Mohamed, Lin, H. C., Omata, Masao, and Sarin, Shiv Kumar

Published
2024
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6. Cellular heterogeneity of pluripotent stem cell-derived cardiomyocyte grafts is mechanistically linked to treatable arrhythmias

Author

Selvakumar, Dinesh, Clayton, Zoe E., Prowse, Andrew, Dingwall, Steve, Kim, Sul Ki, Reyes, Leila, George, Jacob, Shah, Haisam, Chen, Siqi, Leung, Halina H. L., Hume, Robert D., Tjahjadi, Laurentius, Igoor, Sindhu, Skelton, Rhys J. P., Hing, Alfred, Paterson, Hugh, Foster, Sheryl L., Pearson, Lachlan, Wilkie, Emma, Marcus, Alan D., Jeyaprakash, Prajith, Wu, Zhixuan, Chiu, Han Shen, Ongtengco, Cherica Felize J., Mulay, Onkar, McArthur, Jeffrey R., Barry, Tony, Lu, Juntang, Tran, Vu, Bennett, Richard, Kotake, Yasuhito, Campbell, Timothy, Turnbull, Samual, Gupta, Anunay, Nguyen, Quan, Ni, Guiyan, Grieve, Stuart M., Palpant, Nathan J., Pathan, Faraz, Kizana, Eddy, Kumar, Saurabh, Gray, Peter P., and Chong, James J. H.

Published
2024
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8. Coronal Heating as Determined by the Solar Flare Frequency Distribution Obtained by Aggregating Case Studies

Author

Mason, James Paul, Werth, Alexandra, West, Colin G., Youngblood, Allison A., Woodraska, Donald L., Peck, Courtney, Lacjak, Kevin, Frick, Florian G., Gabir, Moutamen, Alsinan, Reema A., Jacobsen, Thomas, Alrubaie, Mohammad, Chizmar, Kayla M., Lau, Benjamin P., Dominguez, Lizbeth Montoya, Price, David, Butler, Dylan R., Biron, Connor J., Feoktistov, Nikita, Dewey, Kai, Loomis, N. E., Bodzianowski, Michal, Kuybus, Connor, Dietrick, Henry, Wolfe, Aubrey M., Guerrero, Matt, Vinson, Jessica, Starbuck, Peter, Litton, Shelby D, Beck, M. G., Fisch, Jean-Paul, West, Ayana, Muniz, Alexis A., Chavez, Luis, Upthegrove, Zachary T., Runyon, Brenton M., Salazar, J., Kritzberg, Jake E., Murrel, Tyler, Ho, Ella, LaFemina, Quintin Y., Elbashir, Sara I., Chang, Ethan C., Hudson, Zachary A., Nussbaum, Rosemary O., Kennedy, Kellen, Kim, Kevin, Arango, Camila Villamil, Albakr, Mohammed A., Rotter, Michael, Garscadden, A. J., Salcido-Alcontar JR, Antonio, Pearl, Harrison M., Stepaniak, Tyler, Marquez, Josie A., Marsh, Lauren, Andringa, Jesse C, Osogwin, Austin, Shields, Amanda M., Brookins, Sarah, Hach, Grace K., Clausi, Alexis R., Millican, Emily B., Jaimes, Alan A, Graham, Alaina S., Burritt, John J., Perez, J. S., Ramirez, Nathaniel, Suri, Rohan, Myer, Michael S., Kresek, Zoe M., Goldsberry, C. A., Payne, Genevieve K., Jourabchi, Tara, Hu, J., Lucca, Jeffrey, Feng, Zitian, Gilpatrick, Connor B., Khan, Ibraheem A., Warble, Keenan, Sweeney, Joshua D., Dorricott, Philip, Meyer, Ethan, Kothamdi, Yash S., Sohail, Arman S., Grell, Kristyn, Floyd, Aidan, Bard, Titus, Mathieson, Randi M., Reed, Joseph, Cisneros, Alexis, Payne, Matthew P., Jarriel, J. R., Mora, Jacqueline Rodriguez, Sundell, M. E., Patel, Kajal, Alesmail, Mohammad, Alnasrallah, Yousef A, Abdullah, Jumana T., Molina-Saenz, Luis, Tayman, K. E., Brown, Gabriel T., Kerr-Layton, Liana, Berriman-Rozen, Zachary D., Hiatt, Quinn, Kalra, Etash, Ong, Jason, Vadayar, Shreenija, Shannahan, Callie D., Benke, Evan, zhang, Jinhua, Geisman, Jane, Martyr, Cara, Ameijenda, Federico, Akruwala, Ushmi H., Nehring, Molly, Kissner, Natalie, Rule, Ian C., Learned, Tyler, Smith, Alexandra N., Mazzotta, Liam, Rounsefell, Tyndall, Eyeson, Elizabeth A., Shelby, Arlee K., Moll, Tyler S, Menke, Riley, Shahba, Hannan, House Jr., Tony A., Clark, David B., Burns, Annemarie C., de La Beaujardiere, Tristan, Trautwein, Emily D., Plantz, Will, Reeves, Justin, Faber, Ian, Buxton, B. W., Highhouse, Nigel, Landrey, Kalin, Hansen, Connor M, Chen, Kevin, Hales, Ryder Buchanan, Borgerding, Luke R., Guo, Mutian, Crow, Christian J., Whittall, Lloyd C., Simmons, Conor, Folarin, Adeduni, Parkinson, Evan J., Rahn, Anna L., Blevins, Olivia, Morelock, Annalise M., Kelly, Nicholas, Parker, Nathan L., Smith, Kelly, Plzak, Audrey E., Saeb, David, Hares, Cameron T., Parker, Sasha R., McCoy, Andrew, Pham, Alexander V., Lauzon, Megan, Kennedy, Cayla J., Reyna, Andrea B., Acosta, Daniela M. Meza, Cool, Destiny J., Steinbarth, Sheen L., Mendoza-Anselmi, Patricia, Plutt, Kaitlyn E., Kipp, Isabel M, Rakhmonova, M., Brown, Cameron L., Van Anne, Gabreece, Moss, Alexander P., Golden, Olivia, Kirkpatrick, Hunter B., Colleran, Jake R., Sullivan, Brandon J, Tran, Kevin, Carpender, Michael Andrew, Mundy, Aria T., Koenig, Greta, Oudakker, Jessica, Engelhardt, Rasce, Ales, Nolan, Wexler, Ethan Benjamin, Beato, Quinn I, Chen, Lily, Cochran, Brooke, Hill, Paula, Hamilton, Sean R., Hashiro, Kyle, Khan, Usman, Martinez, Alexa M., Brockman, Jennifer L., Mallory, Macguire, Reed, Charlie, Terrile, Richard, Singh, Savi, Watson, James Adam, Creany, Joshua B., Price, Nicholas K., Miften, Aya M., Tran, Bryn, Kamenetskiy, Margaret, Martinez, Jose R., Opp, Elena N., Huang, Jianyang, Fails, Avery M., Belei, Brennan J., Slocum, Ryan, Astalos, Justin, East, Andrew, Nguyen, Lena P., Pherigo, Callie C, East, Andrew N., Li, David Y., Nelson, Maya LI, Taylor, Nicole, Odbayar, Anand, Rives, Anna Linnea, Mathur, Kabir P., Billingsley, Jacob, Polikoff, Hyden, Driscoll, Michael, Wilson, Orion K., Lahmers, Kyle, Toon, Nathaniel J., Lippincott, Sam, Musgrave, Andrew J., Gregory, Alannah H., Pitsuean-Meier, Sedique, Jesse, Trevor, Smith, Corey, Miles, Ethan J., Kainz, Sabrina J. H. T., Ji, Soo Yeun, Nguyen, Lena, Aryan, Maryam, Dinser, Alexis M., Shortman, Jadon, Bastias, Catalina S, Umbricht, Thomas D, Cage, Breonna, Randolph, Parker, Pollard, Matthew, Simone, Dylan M., Aramians, Andrew, Brecl, Ariana E., Robert, Amanda M., Zenner, Thomas, Saldi, Maxwell, Morales, Gavin, Mendez, Citlali, Syed, Konner, Vogel, Connor Maklain, Cone, Rebecca A., Berhanu, Naomi, Carpenter, Emily, Leoni, Cecilia, Bryan, Samuel, Ramachandra, Nidhi, Shaw, Timothy, Lee, E. C., Monyek, Eli, Wegner, Aidan B., Sharma, Shajesh, Lister, Barrett, White, Jamison R., Willard, John S., Sulaiman, S. A, Blandon, Guillermo, Narayan, Anoothi, Ruger, Ryan, Kelley, Morgan A., Moreno, Angel J., Balcer, Leo M, Ward-Chene, N. R. D., Shelby, Emma, Reagan, Brian D., Marsh, Toni, Sarkar, Sucheta, Kelley, Michael P., Fell, Kevin, Balaji, Sahana, Hildebrand, Annalise K., Shoha, Dominick, Nandu, Kshmya, Tucker, Julia, Cancio, Alejandro R., Wang, Jiawei, Rapaport, Sarah Grace, Maravi, Aimee S., Mayer, Victoria A., Miller, Andrew, Bence, Caden, Koke, Emily, Fauntleroy, John T, Doermer, Timothy, Al-Ghazwi, Adel, Morgan, Remy, Alahmed, Mohammed S., Mathavan, Adam Izz Khan Mohd Reduan, Silvester, H. K., Weiner, Amanda M., Liu, Nianzi, Iovan, Taro, Jensen, Alexander V., AlHarbi, Yazeed A., Jiang, Yufan, Zhang, Jiaqi, Jones, Olivia M., Huang, Chenqi, Reh, Eileen N., Alhamli, Dania, Pettine, Joshua, Zhou, Chongrui, Kriegman, Dylan, Yang, Jianing, Ash, Kevin, Savage, Carl, Kaiser, Emily, Augenstein, Dakota N., Padilla, Jacqueline, Stark, Ethan K., Hansen, Joshua A., Kokes, Thomas, Huynh, Leslie, Sanchez-Sanchez, Gustavo, Jeseritz, Luke A., Carillion, Emma L., Vepa, Aditya V., Khanal, Sapriya, Behr, Braden, Martin, Logan S., McMullan, Jesse J., Zhao, Tianwei, Williams, Abigail K., Alqabani, Emeen, Prinster, Gale H., Horne, Linda, Ruggles-Delgado, Kendall, Otto, Grant, Gomez, Angel R., Nguyen, Leonardo, Brumley, Preston J., Venegas, Nancy Ortiz, Varela, Ilian, Brownlow, Jordi, Cruz, Avril, Leiker, Linzhi, Batra, Jasleen, Hutabarat, Abigail P., Nunes-Valdes, Dario, Jameson, Connor, Naqi, Abdulaziz, Adams, Dante Q., Biediger, Blaine B., Borelli, William T, Cisne, Nicholas A., Collins, Nathaniel A., Curnow, Tyler L., Gopalakrishnan, Sean, Griffin, Nicholas F., Herrera, Emanuel, McGarvey, Meaghan V., Mellett, Sarah, Overchuk, Igor, Shaver, Nathan, Stratmeyer, Cooper N., Vess, Marcus T., Juels, Parker, Alyami, Saleh A., Gale, Skylar, Wallace, Steven P., Hunter, Samuel C, Lonergan, Mia C., Stewart, Trey, Maksimuk, Tiffany E., Lam, Antonia, Tressler, Judah, Napoletano, Elena R., Miller, Joshua B., Roy, Marc G., Chanders, Jasey, Fischer, Emmalee, Croteau, A. J., Kuiper, Nicolas A., Hoffman, Alex, DeBarros, Elyse, Curry, Riley T., Brzostowicz, A., Courtney, Jonas, Zhao, Tiannie, Szabo, Emi, Ghaith, Bandar Abu, Slyne, Colin, Beck, Lily, Quinonez, Oliver, Collins, Sarah, Madonna, Claire A., Morency, Cora, Palizzi, Mallory, Herwig, Tim, Beauprez, Jacob N., Ghiassi, Dorsa, Doran, Caroline R., Yang, Zhanchao, Padgette, Hannah M., Dicken, Cyrus A., Austin, Bryce W., Phalen, Ethan J., Xiao, Catherine, Palos, Adler, Gerhardstein, Phillip, Altenbern, Ava L., Orbidan, Dan, Dorr, Jackson A., Rivas, Guillermo A., Ewing, Calvin A, Giebner, B. C., McEntee, Kelleen, Kite, Emily R., Crocker, K. A., Haley, Mark S., Lezak, Adrienne R., McQuaid, Ella, Jeong, Jacob, Albaum, Jonathan, Hrudka, E. M., Mulcahy, Owen T., Tanguma, Nolan C., Oishi-Holder, Sean, White, Zachary, Coe, Ryan W., Boyer, Christine, Chapman, Mitchell G., Fortino, Elise, Salgado, Jose A., Hellweg, Tim, Martinez, Hazelia K., Mitchell, Alexander J., Schubert, Stephanie H., Schumacher, Grace K, Tesdahl, Corey D, Uphoff, C. H., Vassilyev, Alexandr, Witkoff, Briahn, Wolle, Jackson R., Dice, Kenzie A., Behrer, Timothy A., Bowen, Troy, Campbell, Andrew J, Clarkson, Peter C, Duong, Tien Q., Hawat, Elijah, Lopez, Christian, Olson, Nathaniel P., Osborn, Matthew, Peou, Munisettha E., Vaver, Nicholas J., Husted, Troy, Kallemeyn, Nicolas Ian, Spangler, Ava A, Mccurry, Kyle, Schultze, Courtney, Troisi, Thomas, Thomas, Daniel, Ort, Althea E., Singh, Maya A., Soon, Caitlin, Patton, Catherine, Billman, Jayce A., Jarvis, Sam, Hitt, Travis, Masri, Mirna, Albalushi, Yusef J., Schofer, Matthew J, Linnane, Katherine B., Knott, Philip Whiting, Valencia, Whitney, Arias-Robles, Brian A., Ryder, Diana, Simone, Anna, Abrams, Jonathan M., Belknap, Annelene L., Rouse, Charlotte, Reynolds, Alexander, Petric, Romeo S. L., Gomez, Angel A., Meiselman-Ashen, Jonah B., Carey, Luke, Dias, John S., Fischer-White, Jules, Forbes, Aidan E., Galarraga, Gabriela, Kennedy, Forrest, Lawlor, Rian, Murphy, Maxwell J., Norris, Cooper, Quarderer, Josh, Waller, Caroline, Weber, Robert J., Gunderson, Nicole, Boyne, Tom, Gregory, Joshua A., Propper, Henry Austin, von Peccoz, Charles B. Beck, Branch, Donovan, Clarke, Evelyn, Cutler, Libby, Dabberdt, Frederick M., Das, Swagatam, Figueirinhas, John Alfred D., Fougere, Benjamin L., Roy, Zoe A., Zhao, Noah Y., Cox, Corben L., Barnhart, Logan D. W., Craig, Wilmsen B., Moll, Hayden, Pohle, Kyle, Mueller, Alexander, Smith, Elena K., Spicer, Benjamin C., Aycock, Matthew C., Bat-Ulzii, Batchimeg, Murphy, Madalyn C., Altokhais, Abdullah, Thornally, Noah R., Kleinhaus, Olivia R., Sarfaraz, Darian, Barnes, Grant M., Beard, Sara, Banda, David J, Davis, Emma A. B., Huebsch, Tyler J., Wagoner, Michaela, Griego, Justus, Hale, Jack J. Mc, Porter, Trevor J., Abrashoff, Riley, Phan, Denise M., Smith, Samantha M., Srivastava, Ashish, Schlenker, Jared A. W., Madsen, Kasey O., Hirschmann, Anna E., Rankin, Frederick C, Akbar, Zainab A., Blouin, Ethan, Coleman-Plante, Aislinn, Hintsa, Evan, Lookhoff, Emily, Amer, Hamzi, Deng, Tianyue, Dvorak, Peter, Minimo, Josh, Plummer, William C., Ton, Kelly, Solt, Lincoln, AlAbbas, Batool H., AlAwadhi, Areej A., Cooper, Nicholas M., Corbitt, Jessica S, Dunlap, Christian, Johnson, Owen, Malone, Ryan A., Tellez, Yesica, Wallace, Logan, Ta, Michael-Tan D., Wheeler, Nicola H., Ramirez, Ariana C., Huang, Shancheng, Mehidic, Amar, Christiansen, Katherine E, Desai, Om, Domke, Emerson N., Howell, Noah H., Allsbrook, Martin, Alnaji, Teeb, England, Colin, Siles, Nathan, Burton, Nicholas David, Cruse, Zoe, Gilmartin, Dalton, Kim, Brian T., Hattendorf, Elsie, Buhamad, Maryam, Gayou, Lily, Seglem, Kasper, Alkhezzi, Tameem, Hicks, Imari R., Fife, Ryann, Pelster, Lily M., Fix, Alexander, Sur, Sohan N., Truong, Joshua K., Kubiak, Bartlomiej, Bondar, Matthew, Shi, Kyle Z., Johnston, Julia, Acevedo, Andres B., Lee, Junwon, Solorio, William J., Johnston, Braedon Y., McCormick, Tyler, Olguin, Nicholas, Pastor, Paige J., Wilson, Evan M., Trunko, Benjamin L., Sjoroos, Chris, Adams, Kalvyn N, Bell, Aislyn, Brumage-Heller, Grant, Canales, Braden P., Chiles, Bradyn, Driscoll, Kailer H., Hill, Hallie, Isert, Samuel A., Ketterer, Marilyn, Kim, Matthew M., Mewhirter, William J., Phillips, Lance, Phommatha, Krista, Quinn, Megan S., Reddy, Brooklyn J., Rippel, Matthew, Russell, Bowman, Williams, Sajan, Pixley, Andrew M., Gapin, Keala C., Peterson, B., Ruprecht, Collin, Hardie, Isabelle, Li, Isaac, Erickson, Abbey, Gersabeck, Clint, Gopalani, Mariam, Allanqawi, Nasser, Burton, Taylor, Cahn, Jackson R., Conti, Reese, White, Oliver S., Rojec, Stewart, Hogen, Blake A., Swartz, Jason R., Dick, R., Battist, Lexi, Dunn, Gabrielle M., Gasser, Rachel, Logan, Timothy W., Sinkovic, Madeline, Schaller, Marcus T., Heintz, Danielle A., Enrich, Andrew, Sanchez, Ethan S., Perez, Freddy, Flores, Fernando, Kapla, Shaun D., Shockley, Michael C., Phillips, Justin, Rumley, Madigan, Daboub, Johnston, Karsh, Brennan J., Linders, Bridget, Chen, Sam, Do, Helen C., Avula, Abhinav, French, James M., Bertuccio, Chrisanna, Hand, Tyler, Lee, Adrianna J., Neeland, Brenna K, Salazar, Violeta, Andrew, Carter, Barmore, Abby, Beatty, Thomas, Alonzi, Nicholas, Brown, Ryan, Chandler, Olivia M., Collier, Curran, Current, Hayden, Delasantos, Megan E., Bonilla, Alberto Espinosa de los Monteros, Fowler, Alexandra A., Geneser, Julianne R., Gentry, Eleanor, Gustavsson, E. R., Hansson, Jonathan, Hao, Tony Yunfei, Herrington, Robert N., Kelly, James, Kelly, Teagan, Kennedy, Abigail, Marquez, Mathew J., Meillon, Stella, Palmgren, Madeleine L., Pesce, Anneliese, Ranjan, Anurag, Robertson, Samuel M., Smith, Percy, Smith, Trevor J, Soby, Daniel A., Stratton, Grant L., Thielmann, Quinn N., Toups, Malena C., Veta, Jenna S., Young, Trenton J., Maly, Blake, Manzanares, Xander R., Beijer, Joshua, George, Jacob D., Mills, Dylan P., Ziebold, Josh J, Chambers, Paige, Montoya, Michael, Cheang, Nathan M., Anderson, Hunter J., Duncan, Sheridan J., Ehrlich, Lauren, Hudson, Nathan C., Kiechlin, Jack L., Koch, Will, Lee, Justin, Menassa, Dominic, Oakes, S. H., Petersen, Audrey J., Bunsow, J. R. Ramirez, Bay, Joshua, Ramirez, Sacha, Fenwick, Logan D., Boyle, Aidan P., Hibbard, Lea Pearl, Haubrich, Calder, Sherry, Daniel P., Jenkins, Josh, Furney, Sebastian, Velamala, Anjali A., Krueger, Davis J., Thompson, William N., Chhetri, Jenisha, Lee, Alexis Ying-Shan, Ray, Mia G. V., Recchia, John C., Lengerich, Dylan, Taulman, Kyle, Romero, Andres C., Steward, Ellie N., Russell, Sloan, Hardwick, Dillon F., Wootten, Katelynn, Nguyen, Valerie A., Quispe, Devon, Ragsdale, Cameron, Young, Isabel, Atchley-Rivers, N. S., Stribling, Jordin L., Gentile, Julia G, Boeyink, Taylor A., Kwiatkowski, Daniel, Dupeyron, Tomi Oshima, Crews, Anastasia, Shuttleworth, Mitchell, Dresdner, Danielle C., Flackett, Lydia, Haratsaris, Nicholas, Linger, Morgan I, Misener, Jay H., Patti, Samuel, Pine, Tawanchai P., Marikar, Nasreen, Matessi, Giorgio, Routledge, Allie C., Alkaabi, Suhail, Bartman, Jessica L., Bisacca, Gabrielle E., Busch, Celeste, Edwards, Bree, Staudenmier, Caitlyn, Starling, Travis, McVey, Caden, Montano, Maximus, Contizano, Charles J., Taylor, Eleanor, McIntyre, James K., Victory, Andrew, McCammon, Glen S., Kimlicko, Aspen, Sheldrake, Tucker, Shelchuk, Grace, Von Reich, Ferin J., Hicks, Andrew J., O'neill, Ian, Rossman, Beth, Taylor, Liam C., MacDonald, William, Becker, Simone E., Han, Soonhee, O'Sullivan, Cian, Wilcove, Isaac, Brennan, David J., Hanley, Luke C., Hull, Owen, Wilson, Timothy R., Kalmus, Madison H., Berv, Owen A., Harris, Logan Swous, Doan, Chris H, Londres, Nathan, Parulekar, Anish, Adam, Megan M., Angwin, Abigail, Cabbage, Carter C., Colleran, Zachary, Pietras, Alex, Seux, Octave, Oros, Ryan, Wilkinson, Blake C., Nguyen, Khoa D, Trank-Greene, Maedee, Barone, Kevin M., Snyder, G. L., Biehle, Samuel J, Billig, Brennen, Almquist, Justin Thomas, Dixon, Alyssa M., Erickson, Benjamin, Evans, Nathan, Genne, SL, Kelly, Christopher M, Marcus, Serafima M., Ogle, Caleb, Patel, Akhil, Vendetti, Evan, Courtney, Olivia, Deel, Sean, Del Foco, Leonardo, Gjini, Michael, Haines, Jessica, Hoff, Isabelle J., Jones, M. R., Killian, Dominic, Kuehl, Kirsten, Kuester, Chrisanne, Lantz, Maxwell B., Lee, Christian J, Mauer, Graham, McKemey, Finbar K., Millican, Sarah J., Rosasco, Ryan, Stewart, T. C., VanEtten, Eleanor, Derwin, Zachary, Serio, Lauren, Sickler, Molly G., Blake, Cassidy A., Patel, Neil S., Fox, Margaret, Gray, Michael J, Ziegler, Lucas J., Kumar, Aman Priyadarshi, Polly, Madelyn, Mesgina, Sarah, McMorris, Zane, Griffin, Kyle J., Haile, L. N., Bassel, Claire, Dixon, Thomas J., Beattie, Ryan, Houck, Timothy J, Rodgers, Maeve, Trofino, Tyson R., Lukianow, Dax, Smart, Korben, Hall, Jacqueline L., Bone, Lauren, Baldwin, James O., Doane, Connor, Almohsen, Yousef A., Stamos, Emily, Acha, Iker, Kim, Jake, Samour II, Antonio E., Chavali, S., Kanokthippayakun, Jeerakit, Gotlib, Nicholas, Murphy, Ryan C., Archibald, Jack. W., Brimhall, Alexander J, Boyer, Aidan, Chapman, Logan T., Chadda, Shivank, Sibrell, Lisa, Vallery, Mia M., Conroy, Thomas C., Pan, Luke J., Balajonda, Brian, Fuhrman, Bethany E. S., Alkubaisi, Mohamed, Engelstad, Jacob, Dodrill, Joshua, Fuchs, Calvin R., Bullard-Connor, Gigi, Alhuseini, Isehaq, Zygmunt, James C., Sipowicz, Leo, Hayrynen, Griffin A., McGill, Riley M., Keating, Caden J., Hart, Omer, Cyr, Aidan St., Steinsberger, Christopher H., Thoman, Gerig, Wood, Travis M., Ingram, Julia A., Dominguez, J., Georgiades, Nathaniel James, Johnson, Matthew, Johnson, Sawyer, Pedersen, Alexander J., Ralapanawe, Anoush K, Thomas, Jeffrey J., Sato, Ginn A., Reynolds, Hope, Nasser, Liebe, Mizzi, Alexander Z., Damgaard, Olivia, Baflah, Abdulrahman A., Liu, Steven Y., Salindeho, Adam D., Norden, Kelso, Gearhart, Emily E., Krajnak, Zack, Szeremeta, Philip, Amos, Meggan, Shin, Kyungeun, Muckenthaler, Brandon A., Medialdea, Melissa, Beach, Simone, Wilson, Connor B., Adams, Elena R, Aldhamen, Ahmed, Harris, Coyle M., Hesse, Troy M., Golding, Nathan T., Larter, Zachary, Hernandez, Angel, Morales, Genaro, Traxler, Robert B., Alosaimi, Meshal, Fitton, Aidan F., Aaron, James Holland, Lee, Nathaniel F., Liao, Ryan Z., Chen, Judy, French, Katherine V., Loring, Justin, Colter, Aurora, McConvey, Rowan, Colozzi, Michael, Vann, John D., Scheck, Benjamin T., Weigand, Anthony A, Alhabeeb, Abdulelah, Idoine, Yolande, Woodard, Aiden L., Medellin, Mateo M., Ratajczyk, Nicholas O, Tobin, Darien P., Collins, Jack C., Horning, Thomas M., Pellatz, Nick, Pitten, John, Lordi, Noah, Patterson, Alyx, Hoang, Thi D, Zimmermann, Ingrid H, Wang, Hongda, Steckhahn, Daniel, Aradhya, Arvind J., Oliver, Kristin A., Cai, Yijian, Wang, Chaoran, Yegovtsev, Nikolay, Wu, Mengyu, Ganesan, Koushik, Osborne, Andrew, Wickenden, Evan, Meyer, Josephine C., Chaparro, David, Visal, Aseem, Liu, Haixin, Menon, Thanmay S., Jin, Yan, Wilson, John, Erikson, James W., Luo, Zheng, Shitara, Nanako, Nelson, Emma E, Geerdts, T. R., Ortiz, Jorge L Ramirez, and Lewandowski, H. J.

Subjects
Astrophysics - Solar and Stellar Astrophysics
Abstract

Flare frequency distributions represent a key approach to addressing one of the largest problems in solar and stellar physics: determining the mechanism that counter-intuitively heats coronae to temperatures that are orders of magnitude hotter than the corresponding photospheres. It is widely accepted that the magnetic field is responsible for the heating, but there are two competing mechanisms that could explain it: nanoflares or Alfv\'en waves. To date, neither can be directly observed. Nanoflares are, by definition, extremely small, but their aggregate energy release could represent a substantial heating mechanism, presuming they are sufficiently abundant. One way to test this presumption is via the flare frequency distribution, which describes how often flares of various energies occur. If the slope of the power law fitting the flare frequency distribution is above a critical threshold, $\alpha=2$ as established in prior literature, then there should be a sufficient abundance of nanoflares to explain coronal heating. We performed $>$600 case studies of solar flares, made possible by an unprecedented number of data analysts via three semesters of an undergraduate physics laboratory course. This allowed us to include two crucial, but nontrivial, analysis methods: pre-flare baseline subtraction and computation of the flare energy, which requires determining flare start and stop times. We aggregated the results of these analyses into a statistical study to determine that $\alpha = 1.63 \pm 0.03$. This is below the critical threshold, suggesting that Alfv\'en waves are an important driver of coronal heating., Comment: 1,002 authors, 14 pages, 4 figures, 3 tables, published by The Astrophysical Journal on 2023-05-09, volume 948, page 71

Published
2023
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9. SAT-129 Sub-optimal global public health policies and strategies to combat hepatocellular carcinoma

Author

Diaz, Luis Antonio, Norero, Blanca, Corsi, Oscar, Ayares, Gustavo, Idalsoaga, Francisco, García, Sergio, Vázquez, Valeria, Lacalle, Lucas, Lazo, Mariana, Ferreccio, Catterina, Mendizabal, Manuel, Piñero, Federico, Martinez, Edmundo, Ijeoma, Ifeorah, Louvet, Alexandre, Piano, Salvatore, Cortez-Pinto, Helena, Wong, Vincent Wai-Sun, Kulkarni, Anand, Cotter, Thomas, Brahmania, Mayur, roblero, Juan Pablo, Dirchwolf, Melisa, Pollarsky, Florencia, George, Jacob, Stauber, Rudolf E, Francque, Sven, Guerra, Patricia, Oliveira, Claudia, Araujo, Roberta, Álvares-da-Silva, Mario, Blaise, Nkegoum, Abraldes, Juan G, Zheng, Ming-Hua, Toro, Luis, Restrepo, Juan Carlos, Ramirez, Wagner, Grgurević, Ivica, Infante, Mirtha, Mbendi, Charles, Carrera, Enrique, Kassas, Mohamed El, Mahmoud, Abdelmajeed, Tesfaye, Yonas Gedamu, Tadesse, Sewale Anagaw, Akalu, Tiruwork Fekadu, Desalegn, Hailemichael, Allaire, Manon, Patrizia, Carrieri, Schattenberg, Jörn, Aguyire, Joan, Micah, Eileen Akonobea, Tachi, Kenneth, Cardona, Katherine Emilia Maldonado, Sanchez, Abel, Sánchez, Marco, Björnsson, Einar S, Iavarone, Massimo, Okamoto, Ryuichi, Some, Fatuma, Hellani, Mohammad Fadel, Gonzalez, Veronica Enith Prado, Chávez-Tapia, Norberto Carlos, Méndez-Sánchez, Nahum, Mucumbi, Sheila Constância Mabote, Ugiagbe, Rose Ashinedu, Akande, Kolawole, Nwoko, Chinenye, Ezenkwa, Uchenna Simon, Okoye, Ifeoma Joy, Hamid, Saeed Sadiq, Quezada, Julissa Lombardo, Girala, Marcos, Padilla, P Martin, Diaz-Ferrer, Javier, Tagle, Martin, Kukla, Michał, Odeghe, Emuobor, wemimo, Rasheed mumini, Reis, Daniela, Mozgovoi, Sergei, Ismail, Mona, Koller, Tomas, Spearman, Wendy, Elhassan, Moawia, Stal, Per, Pazi, Swaleh, Ocanit, Anthony, Masson, Steven, Dunn, Winston, Kamath, Patrick S, Singal, Ashwani, Debes, Jose, Reig, María, Loomba, Rohit, Bataller, Ramon, Lazarus, Jeffrey, Arrese, Marco, and Arab, Juan Pablo

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Public Health and Health Services, Gastroenterology & Hepatology, Clinical sciences
Published
2023

13. Asia–Pacific association for study of liver guidelines on management of ascites in liver disease

Author

Singh, Virendra, De, Arka, Mehtani, Rohit, Angeli, Paolo, Maiwall, Rakhi, Satapathy, Sanjaya, Singal, Ashwini K., Saraya, Anoop, Sharma, B. C., Eapen, C. E., Rao, P. N., Shukla, Akash, Shalimar, Choudhary, Narendra S., Alcantara-Payawal, Diana, Arora, Vinod, Aithal, Guru, Kulkarni, Anand, Roy, Akash, Shrestha, Ananta, Mamun al Mahtab, Niriella, Madunil A., Siam, Tan Soek, Zhang, Chun-Qing, Huei, Lee Guan, Yu, Ming-Lung, Roberts, Stuart K., Peng, Cheng-Yuan, Chen, Tao, George, Jacob, Wong, Vincent, Yilmaz, Yusuf, Treeprasertsuk, Sombat, Kurniawan, Juferdy, Kim, Seung Up, Younossi, Zobair M., and Sarin, Shiv Kumar

Published
2023
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15. An international multidisciplinary consensus statement on MAFLD and the risk of CVD

Author

Zhou, Xiao-Dong, Targher, Giovanni, Byrne, Christopher D., Somers, Virend, Kim, Seung Up, Chahal, C. Anwar A., Wong, Vincent Wai-Sun, Cai, Jingjing, Shapiro, Michael D., Eslam, Mohammed, Steg, Philippe Gabriel, Sung, Ki-Chul, Misra, Anoop, Li, Jian-Jun, Brotons, Carlos, Huang, Yuli, Papatheodoridis, George V., Sun, Aijun, Yilmaz, Yusuf, Chan, Wah Kheong, Huang, Hui, Méndez-Sánchez, Nahum, Alqahtani, Saleh A., Cortez-Pinto, Helena, Lip, Gregory Y. H., de Knegt, Robert J., Ocama, Ponsiano, Romero-Gomez, Manuel, Fudim, Marat, Sebastiani, Giada, Son, Jang Won, Ryan, John D., Ikonomidis, Ignatios, Treeprasertsuk, Sombat, Pastori, Daniele, Lupsor-Platon, Monica, Tilg, Herbert, Ghazinyan, Hasmik, Boursier, Jerome, Hamaguchi, Masahide, Nguyen, Mindie H., Fan, Jian-Gao, Goh, George Boon-Bee, Al Mahtab, Mamun, Hamid, Saeed, Perera, Nilanka, George, Jacob, and Zheng, Ming-Hua

Published
2023
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16. No child's play: Under-five child feces management in a rural area of Bengaluru Urban District, India

Author

Anissa Mary Thomas Thattil, Twinkle Agrawal, Abdul Kader Surti, Stallon Sebastian, Kiyana Mirza, George Jacob, and Farah Naaz Fathima

Subjects
child, defecation, feces, sanitation, under-five, Public aspects of medicine, RA1-1270
Abstract

Background: Inappropriate feces disposal leads to environmental contamination, and increases the risk of exposure to children. We aimed to estimate the proportion of rural households with knowledge and practice of safe management of feces (SMoF) among under-five children and to identify associated factors. Materials and Methods: A cross-sectional study was conducted in eight villages in Bengaluru Urban district over 2 months, using a face-validated semi-structured interview schedule. SMoF was defined based on five criteria – defecation site, transport tool, feces disposal, cleaning of transport tool, and hand washing. Results: Out of 320 under-five children surveyed, 15.7% were pre-ambulatory and 84.3% were ambulatory. The majority of the caregivers (92.5%) felt that children should defecate in the latrine and only 23.7% were aware that child feces were more infectious than adult feces. SMoF was only practiced by caregivers of ambulatory children (52.6%). Households with older caregivers (P = 0.01) and those living in a pucca house (P = 0.02) with a latrine inside (P = 0.04) were found to practice SMoF. Children of households that practiced unsafe disposal of child feces experienced more diarrheal episodes (P = 0.04). Caregivers >20 years were found to have better odds of SMoF [20–25 years (adjusted odds ratio, aOR: 9.02), 26–30 years (aOR: 12.17), >30 years (aOR: 8.93)] compared to those

Published
2024
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17. Acetabular cup positioning in primary routine total hip arthroplasty—a review of current concepts and technologies

Author

Aravind Sai Sathikumar, George Jacob, Appu Benny Thomas, Jacob Varghese, and Venugopal Menon

Subjects
Acetabular cup positioning, Primary THA, Robotic THA, Patient specific instrumentation, Navigation THA, Spinopelvic relation, Orthopedic surgery, RD701-811
Abstract

Abstract Introduction Total hip arthroplasty (THA) has revolutionized the treatment of hip joint arthritis. With the increased popularity and success of the procedure, research has focused on improving implant survival and reducing surgical complications. Optimal component orientation has been a constant focus with various philosophies proposed. Regardless of the philosophy, achieving an accurate acetabular position for each clinical scenario is crucial. In this paper, we review the recent developments in improving the accuracy and ideal positioning of the acetabular cup in routine primary THA. Methodology A review of the recent scientific literature for acetabular cup placement in primary THA was performed, with available evidence for safe zones, spinopelvic relationship, preoperative planning, patient-specific instrumentation, navigation THA and robotic THA. Conclusion Though the applicability of Lewinnek safe zones has been questioned with an improved understanding of spinopelvic relationships, its role remains in positioning the acetabular cup in a patient with normal spinopelvic alignment and mobility. Evaluation of spinopelvic relationships and accordingly adjusting acetabular anteversion and inclination can significantly reduce the incidence of dislocation in patients with a rigid spine. In using preoperative radiography, the acetabular inclination, anteversion and intraoperative pelvic position should be evaluated. With improving technology and the advent of artificial intelligence, superior and more accurate preoperative planning is possible. Patient-specific instrumentation, navigated and robotic THA have been reported to improve accuracy in acetabular cup positioning as decided preoperatively but any significant clinical advantage over conventional THA is yet to be elucidated.

Published
2023
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21. An international multidisciplinary consensus on pediatric metabolic dysfunction-associated fatty liver disease

Author

Zhang, Le, El-Shabrawi, Mortada, Baur, Louise A., Byrne, Christopher D., Targher, Giovanni, Kehar, Mohit, Porta, Gilda, Lee, Way Seah, Lefere, Sander, Turan, Serap, Alisi, Anna, Weiss, Ram, Faienza, Maria Felicia, Ashraf, Ambika, Sundaram, Shikha S., Srivastava, Anshu, De Bruyne, Ruth, Kang, Yunkoo, Bacopoulou, Flora, Zhou, Yong-Hai, Darma, Andy, Lupsor-Platon, Monica, Hamaguchi, Masahide, Misra, Anoop, Méndez-Sánchez, Nahum, Ng, Nicholas Beng Hui, Marcus, Claude, Staiano, Amanda E., Waheed, Nadia, Alqahtani, Saleh A., Giannini, Cosimo, Ocama, Ponsiano, Nguyen, Mindie H., Arias-Loste, Maria Teresa, Ahmed, Mohamed Rabea, Sebastiani, Giada, Poovorawan, Yong, Al Mahtab, Mamun, Pericàs, Juan M., Reverbel da Silveira, Themis, Hegyi, Peter, Azaz, Amer, Isa, Hasan M., Lertudomphonwanit, Chatmanee, Farrag, Mona Issa, Nugud, Ahmed Abd Alwahab, Du, Hong-Wei, Qi, Ke-Min, Mouane, Nezha, Cheng, Xin-Ran, Al Lawati, Tawfiq, Fagundes, Eleonora D.T., Ghazinyan, Hasmik, Hadjipanayis, Adamos, Fan, Jian-Gao, Gimiga, Nicoleta, Kamal, Naglaa M., Ștefănescu, Gabriela, Hong, Li, Diaconescu, Smaranda, Li, Ming, George, Jacob, and Zheng, Ming-Hua

Published
2024
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25. Repair of osteochondral defects: efficacy of a tissue-engineered hybrid implant containing both human MSC and human iPSC-cartilaginous particles

Author

Shinichi Nakagawa, Wataru Ando, Kazunori Shimomura, David A. Hart, Hiroto Hanai, George Jacob, Ryota Chijimatsu, Seido Yarimitu, Hiromichi Fujie, Seiji Okada, Noriyuki Tsumaki, and Norimasa Nakamura

Subjects
Medicine
Abstract

Abstract Both mesenchymal stromal cells (MSC) and induced pluripotent stem cells (iPSC) offer the potential for repair of damaged connective tissues. The use of hybrid implants containing both human MSC and iPSC was investigated to assess their combined potential to yield enhanced repair of osteochondral defects. Human iPSC-CP wrapped with tissue engineered constructs (TEC) containing human MSC attained secure defect filling with good integration to adjacent tissue in a rat osteochondral injury model. The presence of living MSC in the hybrid implants was required for effective biphasic osteochondral repair. Thus, the TEC component of such hybrid implants serves several critical functions including, adhesion to the defect site via the matrix and facilitation of the repair via live MSC, as well as enhanced angiogenesis and neovascularization. Based on these encouraging studies, such hybrid implants may offer an effective future intervention for repair of complex osteochondral defects.

Published
2023
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26. The fibroblast hormone Endotrophin is a biomarker of mortality in chronic diseases

Author

Genovese, Federica, Bager, Cecilie, Frederiksen, Peder, Vazquez, Dario, Sand, Jannie Marie Bülow, Jenkins, R Gisli, Maher, Toby M., Stewart, Iain D., Molyneaux, Philip L., Fahy, William A, Wain, Louise V., Vestbo, Jørgen, Nanthakumar, Carmel, Shaker, Saher Burhan, Hoyer, Nils, Leeming, Diana Julie, George, Jacob, Trebicka, Jonel, Rasmussen, Daniel Guldager Kring, Hansen, Michael K., Cockwell, Paul, Kremer, Daan, Bakker, Stephan JL, Selby, Nicholas M, Reese-Petersen, Alexander Lynge, González, Arantxa, Núñez, Julio, Rossing, Peter, Nissen, Neel I., Boisen, Mogens Karsbøl, Chen, Inna M., Zhao, Lei, Karsdal, Morten A., and Schuppan, Detlef

Published
2024
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29. N-terminal propeptide of type 3 collagen-based sequential algorithm can identify high-risk steatohepatitis and fibrosis in MAFLD

Author

Tang, Liang-Jie, Li, Gang, Eslam, Mohammed, Zhu, Pei-Wu, Chen, Sui-Dan, Leung, Howard Ho-Wai, Huang, Ou-Yang, Wong, Grace Lai-Hung, Zhou, Yu-Jie, Karsdal, Morten, Leeming, Diana Julie, Jiang, Pei, Wang, Cong, Yuan, Hai-Yang, Byrne, Christopher D., Targher, Giovanni, George, Jacob, Wong, Vincent Wai-Sun, and Zheng, Ming-Hua

Published
2023
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34. Validation of the Blood Test MACK-3 for the Noninvasive Diagnosis of Fibrotic Nonalcoholic Steatohepatitis: An International Study With 1924 Patients

Author

Canivet, Clémence M., Zheng, Ming-Hua, Qadri, Sami, Vonghia, Luisa, Chuah, Kee-Huat, Costentin, Charlotte, George, Jacob, Armandi, Angelo, Adams, Leon A., Lange, Naomi F., Blanchet, Odile, Moal, Valérie, Younes, Ramy, Roux, Marine, Chan, Wah-Kheong, Sturm, Nathalie, Eslam, Mohammed, Bugianesi, Elisabetta, Wang, Zhengyi, Dufour, Jean-François, Francque, Sven, Yki-Järvinen, Hannele, Zheng, Kenneth I., and Boursier, Jérôme

Published
2023
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36. Liver Disease and Poor Adherence Limit Hepatitis C Cure: A Real-World Australian Treatment Cohort

Author

Clark, Paul J., Valery, Patricia C., Strasser, Simone I., Weltman, Martin, Thompson, Alexander J., Levy, Miriam, Leggett, Barbara, Zekry, Amany, Rong, Julian, Angus, Peter, George, Jacob, Bollipo, Steven, McGarity, Bruce, Sievert, William, Macquillan, Gerry, Tse, Edmund, Nicoll, Amanda, Wade, Amanda, Chu, Geoff, Harding, Damian, Cheng, Wendy, Farrell, Geoff, and Roberts, Stuart K.

Published
2023
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37. Discrimination Among Multiple Cutaneous and Proprioceptive Hand Percepts Evoked by Nerve Stimulation with Utah Slanted Electrode Arrays in Human Amputees

Author

Page, David M., Wendelken, Suzanne M., Davis, Tyler S., Kluger, David T., Hutchinson, Douglas T., George, Jacob A., and Clark, Gregory A.

Subjects
Quantitative Biology - Neurons and Cognition, Computer Science - Robotics
Abstract

Objective: This paper aims to demonstrate functional discriminability among restored hand sensations with different locations, qualities, and intensities that are evoked by microelectrode stimulation of residual afferent fibers in human amputees. Methods: We implanted a Utah Slanted Electrode Array (USEA) in the median and ulnar residual arm nerves of three transradial amputees and delivered stimulation via different electrodes and at different frequencies to produce various locations, qualities, and intensities of sensation on the missing hand. Blind discrimination trials were performed to determine how well subjects could discriminate among these restored sensations. Results: Subjects discriminated among restored sensory percepts with varying cutaneous and proprioceptive locations, qualities, and intensities in blind trials, including discrimination among up to 10 different location-intensity combinations (15/30 successes, p < 0.0005). Variations in the site of stimulation within the nerve, via electrode selection, enabled discrimination among up to 5 locations and qualities (35/35 successes, p < 0.0001). Variations in the stimulation frequency enabled discrimination among 4 different intensities at the same location (13/20 successes, p < 0.005). One subject discriminated among simultaneous, alternating, and isolated stimulation of two different USEA electrodes, as may be desired during multi-sensor closed-loop prosthesis use (20/25 successes, p < 0.001). Conclusion: USEA stimulation enables encoding of a diversity of functionally discriminable sensations with different locations, qualities, and intensities. Significance: These percepts provide a potentially rich source of sensory feedback that may enhance performance and embodiment during multi-sensor, closed-loop prosthesis use., Comment: 19 pages

Published
2020

38. Inexpensive surface electromyography sleeve with consistent electrode placement enables dexterous and stable prosthetic control through deep learning

Author

George, Jacob A., Neibling, Anna, Paskett, Michael D., and Clark, Gregory A.

Subjects
Computer Science - Robotics, Computer Science - Computer Vision and Pattern Recognition, Quantitative Biology - Neurons and Cognition
Abstract

The dexterity of conventional myoelectric prostheses is limited in part by the small datasets used to train the control algorithms. Variations in surface electrode positioning make it difficult to collect consistent data and to estimate motor intent reliably over time. To address these challenges, we developed an inexpensive, easy-to-don sleeve that can record robust and repeatable surface electromyography from 32 embedded monopolar electrodes. Embedded grommets are used to consistently align the sleeve with natural skin markings (e.g., moles, freckles, scars). The sleeve can be manufactured in a few hours for less than $60. Data from seven intact participants show the sleeve provides a signal-to-noise ratio of 14, a don-time under 11 seconds, and sub-centimeter precision for electrode placement. Furthermore, in a case study with one intact participant, we use the sleeve to demonstrate that neural networks can provide simultaneous and proportional control of six degrees of freedom, even 263 days after initial algorithm training. We also highlight that consistent recordings, accumulated over time to establish a large dataset, significantly improve dexterity. These results suggest that deep learning with a 74-layer neural network can substantially improve the dexterity and stability of myoelectric prosthetic control, and that deep-learning techniques can be readily instantiated and further validated through inexpensive sleeves/sockets with consistent recording locations., Comment: MEC2020

Published
2020

39. Bilaterally Mirrored Movements Improve the Accuracy and Precision of Training Data for Supervised Learning of Neural or Myoelectric Prosthetic Control

Author

George, Jacob A., Tully, Troy N., Colgan, Paul C., and Clark, Gregory A.

Subjects
Computer Science - Robotics, Quantitative Biology - Neurons and Cognition
Abstract

Intuitive control of prostheses relies on training algorithms to correlate biological recordings to motor intent. The quality of the training dataset is critical to run-time performance, but it is difficult to label hand kinematics accurately after the hand has been amputated. We quantified the accuracy and precision of labeling hand kinematics for two different approaches: 1) assuming a participant is perfectly mimicking predetermined motions of a prosthesis (mimicked training), and 2) assuming a participant is perfectly mirroring their contralateral hand during identical bilateral movements (mirrored training). We compared these approaches in non-amputee individuals, using an infrared camera to track eight different joint angles of the hands in real-time. Aggregate data revealed that mimicked training does not account for biomechanical coupling or temporal changes in hand posture. Mirrored training was significantly more accurate and precise at labeling hand kinematics. However, when training a modified Kalman filter to estimate motor intent, the mimicked and mirrored training approaches were not significantly different. The results suggest that the mirrored training approach creates a more faithful but more complex dataset. Advanced algorithms, more capable of learning the complex mirrored training dataset, may yield better run-time prosthetic control., Comment: IEEE EMBC 2020

Published
2020

40. Intensity Discriminability of Electrocutaneous and Intraneural Stimulation Pulse Frequency in Intact Individuals and Amputees

Author

George, Jacob A., Brinton, Mark R., Colgan, Paul C., Colvin, Garrison K., Bensmaia, Sliman J., and Clark, Gregory A.

Subjects
Quantitative Biology - Neurons and Cognition, Computer Science - Robotics
Abstract

Electrical stimulation of residual nerves can be used to provide amputees with intuitive sensory feedback. An important aspect of this artificial sensory feedback is the ability to convey the magnitude of tactile stimuli. Using classical psychophysical methods, we quantified the just-noticeable differences for electrocutaneous stimulation pulse frequency in both intact participants and one transradial amputee. For the transradial amputee, we also quantified the just-noticeable difference of intraneural microstimulation pulse frequency via chronically implanted Utah Slanted Electrode Arrays. We demonstrate that intensity discrimination is similar across conditions: intraneural microstimulation of the residual nerves, electrocutaneous stimulation of the reinnervated skin on the residual limb, and electrocutaneous stimulation of intact hands. We also show that intensity discrimination performance is significantly better at lower pulse frequencies than at higher ones - a finding that's unique to electrocutaneous and intraneural stimulation and suggests that supplemental sensory cues may be present at lower pulse frequencies. These results can help guide the implementation of artificial sensory feedback for sensorized bionic arms., Comment: IEEE EMBC 2020

Published
2020

41. Inexpensive and Portable System for Dexterous High-Density Myoelectric Control of Multiarticulate Prostheses

Author

George, Jacob A., Radhakrishnan, Sridharan, Brinton, Mark R., and Clark, Gregory A.

Subjects
Computer Science - Robotics, Quantitative Biology - Neurons and Cognition
Abstract

Multiarticulate bionic arms are now capable of mimicking the endogenous movements of the human hand. 3D-printing has reduced the cost of prosthetic hands themselves, but there is currently no low-cost alternative to dexterous electromyographic (EMG) control systems. To address this need, we developed an inexpensive (~$675) and portable EMG control system by integrating low-cost microcontrollers with an EMG acquisition device. We validated signal acquisition by comparing the signal-to-noise ratio (SNR) of our system with that of a high-end research-grade system. We also demonstrate the ability to use the low-cost control system for proportional and independent control of various prosthetic hands in real-time. We found that the SNR of the low-cost control system was statistically no worse than 44% of the SNR of a research-grade control system. The RMSEs of predicted hand movements (from a modified Kalman filter) were typically a few percent better than, and not more than 6% worse than, RMSEs of a research-grade system for up to six degrees of freedom when only relatively few (six) EMG electrodes were used. However, RMSEs were generally higher than RMSEs of research-grade systems that utilize considerably more (32) EMG electrodes, guiding future work towards increasing electrode count. Successful instantiation of this low-cost control system constitutes an important step towards the commercialization and wide-spread availability of dexterous bionic hands., Comment: IEEE EMBC 2020

Published
2020

42. A Modular Transradial Bypass Socket for Surface Myoelectric Prosthetic Control in Non-Amputees

Author

Paskett, Michael D., Olsen, Nathaniel R., George, Jacob A., Kluger, David T., Brinton, Mark R., Davis, Tyler S., Duncan, Christopher C., and Clark, Gregory A.

Subjects
Computer Science - Robotics, Quantitative Biology - Neurons and Cognition
Abstract

Bypass sockets allow researchers to perform tests of prosthetic systems from the prosthetic user's perspective. We designed a modular upper-limb bypass socket with 3D-printed components that can be easily modified for use with a variety of terminal devices. Our bypass socket preserves access to forearm musculature and the hand, which are necessary for surface electromyography and to provide substituted sensory feedback. Our bypass socket allows a sufficient range of motion to complete tasks in the frontal working area, as measured on non-amputee participants. We examined the performance of non-amputee participants using the bypass socket on the original and modified Box and Block Tests. Participants moved 11.3 +/- 2.7 and 11.7 +/- 2.4 blocks in the original and modified Box and Block Tests (mean +/- SD), respectively, within the range of reported scores using amputee participants. Range-of-motion for users wearing the bypass socket meets or exceeds most reported range-of-motion requirements for activities of daily living. The bypass socket was originally designed with a freely rotating wrist; we found that adding elastic resistance to user wrist rotation while wearing the bypass socket had no significant effect on motor decode performance. We have open-sourced the design files and an assembly manual for the bypass socket. We anticipate that the bypass socket will be a useful tool to evaluate and develop sensorized myoelectric prosthesis technology., Comment: 8 pages, 5 figures

Published
2019
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43. Intuitive Neuromyoelectric Control of a Dexterous Bionic Arm Using a Modified Kalman Filter

Author

George, Jacob A., Davis, Tyler S., Brinton, Mark R., and Clark, Gregory A.

Subjects
Quantitative Biology - Neurons and Cognition, Computer Science - Robotics
Abstract

Background: Multi-articulate prostheses are capable of performing dexterous hand movements. However, clinically available control strategies fail to provide users with intuitive, independent and proportional control over multiple degrees of freedom (DOFs) in real-time. New Method: We detail the use of a modified Kalman filter (MKF) to provide intuitive, independent and proportional control over six-DOF prostheses such as the DEKA "LUKE" Arm. Input features include neural firing rates recorded from Utah Slanted Electrode Arrays and mean absolute value of intramuscular electromyographic (EMG) recordings. Ad-hoc modifications include thresholds and non-unity gains on the output of a Kalman filter. Results: We demonstrate that both neural and EMG data can be combined effectively. We also highlight that modifications can be optimized to significantly improve performance relative to an unmodified Kalman filter. Thresholds significantly reduced unintended movement and promoted more independent control of the different DOFs. Gain were significantly greater than one and served to amplify participant effort. Optimal modifications can be determined quickly offline and translate to functional improvements online. Using a portable take-home system, participants performed various activities of daily living. Comparison with Existing Methods: In contrast to pattern recognition, the MKF allows users to continuously modulate their force output, which is critical for fine dexterity. The MKF is also computationally efficient and can be trained in less than five minutes. Conclusions: The MKF can be used to explore the functional and psychological benefits associated with long-term, at-home control of dexterous prosthetic hands., Comment: 10 figures. Accepted in J. Neurosci. Methods (2019)

Published
2019

44. A randomised controlled trial of Standard Of Care versus RadioAblaTion in Early Stage HepatoCellular Carcinoma (SOCRATES HCC)

Author

Wigg, Alan, Tibballs, Jonathan, Woodman, Richard, Stuart, Katherine, Le, Hien, Roberts, Stuart K., Olynyk, John K., Strasser, Simone I., Wallace, Michael, Martin, Jarad, Haworth, Annette, Hardcastle, Nicholas, Loo, Kee Fong, Tang, Colin, Lee, Yoo Young, Chu, Julie, De Abreu Lourenco, Richard, Koukourou, Adam, De Boo, Diederick, McLean, Kate, Buck, Jackie, Sawhney, Rohit, Nicoll, Amanda, Dev, Anouk, Wood, Marnie, Braund, Alicia, Weltman, Martin, Khor, Richard, Levy, Miriam, Wang, Tim, Potter, Michael, Haridy, James, Raj, Ashok, Duncan, Oliver, Zekry, Amany, Collier, Natalie, O’Beirne, James, Holliday, Catherine, Trada, Yuvnik, Tronidjaja, Jaw, George, Jacob, and Pryor, David

Published
2024
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46. A phase IIa active-comparator-controlled study to evaluate the efficacy and safety of efinopegdutide in patients with non-alcoholic fatty liver disease

Author

Bruzone, Santiago Oscar, Coronel, Maria Jimena, Gruz, Fernando M., MacKinnon, Ignacio, George, Jacob, Muller, Kate, Lee, Samuel S., Caussy, Cyrielle, Petit, Jean Michel, Ari, Ziv Ben, Braun, Marius, Katchman, Helena, Lurie, Yoav, Veitsman, Ella, Zuckerman, Eli, Aghemo, Alessio, Basili, Stenfania, Fracanzani, Anna Ludovica, Pietrangelo, Antonello, Sacerdoti, David, Rubio Arce, Jose Francisco, de Guevara Cetina, Alma Laura Ladron, Chavez-Tapia, Norberto Carlos, Reyes, Eira Cerda, Pinzon Te, Lourdes Lol-Be, Baker, John R., Ngu, Jeffrey, Orr, David, Janczewska, Ewa, Matusik, Pawel, Stanislaw Sadurski, Maciej Murawski, Akinina, Anna Valerievna, Alpenidze, Diana Nodarievna, Bogomolov, Pavel, Ermakova, Polina Yurievna, Golovach, Albina V., Kim, Sang Gyune, Lee, Jin-Woo, Paik, Yong Han, Park, Jun Yong, Yeon, Jong Eun, Blasco, Victor Vargas, Madueno, Francisco Jose Tinahones, Panero, Jose Luis Calleja, Perez, Esther Molina, Romero-Gómez, Manuel, Cheng, Pin-Nan, Jeng, Wen-Juei, Liu, Chun-Jen, Akyuz, Filiz, Balaban, Hatice Yasemin, Basaranoglu, Metin, Demir, Tevfik, Idilman, Ramazan, Karakan, Tarkan, Gyrina, Olga, Kolesnikova, Olena Vadimivna, Pyvovar, Sergiy M., Oliinyk, Oleksandr, Skrypnyk, Igor, Bassan, Isaac, Bowman, William Kelly, Denham, Douglas Scott, Ghalib, Reem, Lawitz, Eric J., Lucas, Kathryn Jean, Mohseni, Rizwana H., Sanchez, William Eduardo, Vierling, John Moore, Lawitz, Eric, Shankar, R. Ravi, Chaudhri, Eirum, Liu, Jie, Lam, Raymond L.H., Kaufman, Keith D., and Engel, Samuel S.

Published
2023
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47. Liver biopsy-based validation, confirmation and comparison of the diagnostic performance of established and novel non-invasive steatotic liver disease indexes: Results from a large multi-center study

Author

Kouvari, Matina, Valenzuela-Vallejo, Laura, Guatibonza-Garcia, Valentina, Polyzos, Stergios A., Deng, Yixiang, Kokkorakis, Michail, Agraz, Melih, Mylonakis, Sophia C., Katsarou, Angeliki, Verrastro, Ornella, Markakis, Georgios, Eslam, Mohammed, Papatheodoridis, Georgios, George, Jacob, Mingrone, Geltrude, and Mantzoros, Christos S.

Published
2023
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49. A global research priority agenda to advance public health responses to fatty liver disease

Author

Lazarus, Jeffrey V., Mark, Henry E., Allen, Alina M., Arab, Juan Pablo, Carrieri, Patrizia, Noureddin, Mazen, Alazawi, William, Alkhouri, Naim, Alqahtani, Saleh A., Arrese, Marco, Bataller, Ramon, Berg, Thomas, Brennan, Paul N., Burra, Patrizia, Castro-Narro, Graciela E., Cortez-Pinto, Helena, Cusi, Kenneth, Dedes, Nikos, Duseja, Ajay, Francque, Sven M., Hagström, Hannes, Huang, Terry T-K., Wajcman, Dana Ivancovsky, Kautz, Achim, Kopka, Christopher J., Krag, Aleksander, Miller, Veronica, Newsome, Philip N., Rinella, Mary E., Romero, Diana, Sarin, Shiv Kumar, Silva, Marcelo, Spearman, C. Wendy, Tsochatzis, Emmanuel A., Valenti, Luca, Villota-Rivas, Marcela, Zelber-Sagi, Shira, Schattenberg, Jörn M., Wong, Vincent Wai-Sun, Younossi, Zobair M., Aberg, Fredrik, Adams, Leon, Al-Naamani, Khalid, Albadawy, Reda M., Alexa, Zinaida, Allison, Michael, Alnaser, Faisal A., Alswat, Khalid, Alvares-da-Silva, Mario Reis, Alvaro, Domenico, Alves-Bezerra, Michele, Andrade, Raul J., Anstee, Quentin M., Awuku, Yaw Asante, Baatarkhuu, Oidov, Baffy, Gyorgy, Bakieva, Shokhista, Bansal, Meena B., Barouki, Robert, Batterham, Rachel L., Behling, Cynthia, Belfort-DeAguiar, Renata, Berzigotti, Annalisa, Betel, Michael, Bianco, Cristiana, Bosi, Emanuele, Boursier, Jerome, Brunt, Elizabeth M., Bugianesi, Elisabetta, Byrne, Christopher J., Cabrera Cabrejos, Maria Cecilia, Caldwell, Stephen, Carr, Rotonya, Castellanos Fernández, Marlen Ivón, Castera, Laurent, Castillo-López, Maria Gabriela, Caussy, Cyrielle, Cerda-Reyes, Eira, Ceriello, Antonio, Chan, Wah- Kheong, Chang, Yoosoo, Charatcharoenwitthaya, Phunchai, Chavez-Tapia, Norberto, Chung, Raymond T., Colombo, Massimo, Coppell, Kirsten, Cotrim, Helma P., Craxi, Antonio, Crespo, Javier, Dassanayake, Anuradha, Davidson, Nicholas O., De Knegt, Robert, de Ledinghen, Victor, Demir, Münevver, Desalegn, Hailemichael, Diago, Moises, Dillon, John F., Dimmig, Bruce, Dirac, M. Ashworth, Dirchwolf, Melisa, Dufour, Jean-François, Dvorak, Karel, Ekstedt, Mattias, El-Kassas, Mohamed, Elsanousi, Osama M., Elsharkawy, Ahmed M., Elwakil, Reda, Eskridge, Wayne, Eslam, Mohammed, Esmat, Gamal, Fan, Jian- Gao, Ferraz, Maria Lucia, Flisiak, Robert, Fortin, Davide, Fouad, Yasser, Freidman, Scott L., Fuchs, Michael, Gadano, Adrian, Gastaldelli, Amalia, Geerts, Anja, Geier, Andreas, George, Jacob, Gerber, Lynn H., Ghazinyan, Hasmik, Gheorghe, Liana, Kile, Denise Giangola, Girala, Marcos, Boon Bee, George Goh, Goossens, Nicolas, Graupera, Isabel, Grønbæk, Henning, Hamid, Saeed, Hebditch, Vanessa, Henry, Zachary, Hickman, Ingrid J., Hobbs, L. Ansley, Hocking, Samantha L., Hofmann, Wolf Peter, Idilman, Ramazan, Iruzubieta, Paula, Isaacs, Scott, Isakov, Vasily A., Ismail, Mona H., Jamal, Mohammad H., Jarvis, Helen, Jepsen, Peter, Jornayvaz, François, Sudhamshu, K.C., Kakizaki, Satoru, Karpen, Saul, Kawaguchi, Takumi, Keating, Shelley E., Khader, Yousef, Kim, Seung Up, Kim, Won, Kleiner, David E., Koek, Ger, Joseph Komas, Narcisse Patrice, Kondili, Loreta A., Koot, Bart G., Korenjak, Marko, Kotsiliti, Eleni, Koulla, Yiannoula, Kugelmas, Carina, Kugelmas, Marcelo, Labidi, Asma, Lange, Naomi F., Lavine, Joel E., Lazo, Mariana, Leite, Nathalie, Lin, Han-Chieh, Lkhagvaa, Undram, Long, Michelle T., Lopez-Jaramillo, Patricio, Lozano, Adelina, Macedo, Maria Paula, Malekzadeh, Reza, Marchesini, Giulio, Marciano, Sebastian, Martinez, Kim, Martínez Vázquez, Sophia E., Mateva, Lyudmila, Mato, José M., Nlombi, Charles Mbendi, McCary, Alexis Gorden, McIntyre, Jeff, McKee, Martin, Mendive, Juan M., Mikolasevic, Ivana, Miller, Pamela S., Milovanovic, Tamara, Milton, Terri, Moreno-Alcantar, Rosalba, Morgan, Timothy R., Motala, Ayesha, Muris, Jean, Musso, Carla, Nava-González, Edna J., Negro, Francesco, Nersesov, Alexander V., Neuschwander-Tetri, Brent A., Nikolova, Dafina, Norris, Suzanne, Novak, Katja, Ocama, Ponsiano, Ong, Janus P., Ong-Go, Arlinking, Onyekwere, Charles, Padilla, Martin, Pais, Raluca, Pan, Calvin, Panduro, Arturo, Panigrahi, Manas K., Papatheodoridis, Georgios, Paruk, Imran, Patel, Keyur, Gonçalves, Carlos Penha, Figueroa, Marlene Pérez, Pérez-Escobar, Juanita, Pericàs, Juan M., Perseghin, Gianluca, Pessoa, Mário Guimarães, Petta, Salvatore, Marques Souza de Oliveira, Claudia Pinto, Prabhakaran, Dorairaj, Pyrsopoulous, Nikolaos, Rabiee, Atoosa, Ramji, Alnoor, Ratziu, Vlad, Ravendhran, Natarajan, Ray, Katrina, Roden, Michael, Romeo, Stefano, Romero-Gómez, Manuel, Rotman, Yaron, Rouabhia, Samir, Rowe, Ian A., Sadirova, Shakhlo, Alkhatry, Maryam Salem, Salupere, Riina, Satapathy, Sanjaya K., Schwimmer, Jeffrey B., Sebastiani, Giada, Seim, Lynn, Seki, Yosuke, Serme, Abdel Karim, Shapiro, David, Sharvadze, Lali, Shaw, Jonathan E., Shawa, Isaac Thom, Shenoy, Thrivikrama, Shibolet, Oren, Shimakawa, Yusuke, Shubrook, Jay H., Singh, Shivaram Prasad, Sinkala, Edford, Skladany, Lubomir, Skrypnyk, Igor, Song, Myeong Jun, Sookoian, Silvia, Sridharan, Kannan, Stefan, Norbert, Stine, Jonathan G., Stratakis, Nikolaos, Sheriff, Dhastagir Sultan, Sundaram, Shikha S., Svegliati-Baroni, Gianluca, Swain, Mark G., Tacke, Frank, Taheri, Shahrad, Tan, Soek-Siam, Tapper, Elliot B., Targher, Giovanni, Tcaciuc, Eugen, Thiele, Maja, Tiniakos, Dina, Tolmane, Ieva, Torre, Aldo, Torres, Esther A., Treeprasertsuk, Sombat, Trenell, Michael, Turcan, Svetlana, Turcanu, Adela, Valantinas, Jonas, van Kleef, Laurens A., Velarde Ruiz Velasco, Jose Antonio, Vesterhus, Mette, Vilar-Gomez, Eduardo, Waked, Imam, Wattacheril, Julia, Wedemeyer, Heiner, Wilkins, Fonda, Willemse, José, Wong, Robert J., Yilmaz, Yusuf, Yki-Järvinen, Hannele, Yu, Ming-Lung, Yumuk, Volkan, Zeybel, Müjdat, Zheng, Kenneth I., Zheng, Ming-Hua, and Huang, Terry T.-K.

Published
2023
Full Text
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