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3 results on '"George Studzinski"'

1. TRIPHOSPHOPYRIDINE NUCLEOTIDE-LINKED DEHYDROGENASES IN THE ADRENAL CORTEX IN MAN; THE EFFECT OF CORTICOTROPHIN AND THE DISTRIBUTION OF ENZYMES

Author

T. Symington, George Studzinski, and J. K. Grant

Subjects
chemistry.chemical_classification, endocrine system, medicine.medical_specialty, Adrenal cortex, Endocrinology, Diabetes and Metabolism, General Medicine, Adrenocorticotropic hormone, Endocrinology, medicine.anatomical_structure, Enzyme, Adrenocorticotropic Hormone, chemistry, Internal medicine, Adrenal Cortex, medicine, Distribution (pharmacology), Nucleotide, Oxidoreductases, NADP, hormones, hormone substitutes, and hormone antagonists
Abstract

Four TPN linked dehydrogenases – Isocitric Dehydrogenase, Glucose-6-phosphate Dehydrogenase, 6 Phosphogluconic Dehydrogenase and the Malic Enzyme – were studied in human adrenal cortex and found to be present almost exclusively in the soluble part of the cell sap. The effect of corticotrophin on these enzymes was studied by comparing the enzyme activities in the cortex of the adrenal glands removed before and after corticotrophin administration. Glucose-6-phosphate dehydrogenase showed marked increase in activity after corticotrophin administration. This increase was not parallel to the concomitant weight increase occurring in the adrenal gland. Glucose-6-phosphate dehydrogenase is uniformly distributed in the »normal« adrenal cortex. After corticotrophin administration however the increase takes place principally in the middle third of the cortex. These findings are discussed in relation to the current theories of the mechanism of corticotrophin action.

Published
1962

2. Apoptosis : A Practical Approach

Author

George Studzinski and George Studzinski

Subjects
Apoptosis, Apoptosis--Laboratory manuals
Abstract

This text is designed to provide conceptual outlines and detailed procedures for basic and advanced studies of cell death by apoptosis. Chapters on the recognition of apoptosis as distinguished from necrosis and nonspecific cell DNA damage, are followed by a systematic examination of the established and the principal novel methodologies utilized by some leading laboratories conducting research on apoptosis. The organization is on the lines of signalling for apoptosis, the apoptotic cascade, and the execution of apoptosis. A wide variety of procedures are provided which will enable the reader to participate in cutting-edge research.

Published
1999

3. Cell Growth, Differentiation and Senescence : A Practical Approach

Author

George Studzinski and George Studzinski

Subjects
Cell differentiation, Cell death--Laboratory manuals, Cells--Growth--Research--Laboratory manuals, Cell differentiation--Laboratory manuals
Abstract

There are three main themes running through this volume. First, basic methods for measurement of cell proliferation are introduced and explained with reference to various systems, primarily in vitro, but in vivo procedures are also illustrated. The second theme is growth signalling, and is exemplified by methods for the analysis of transduction pathways for growth, beginning at the cell membrane and leading to the cell nucleus. The last theme presented here is growth cessation, illustrated by several systems for induction of cell differentiation, and of cell senescence. The emphasis throughout the book is on human cell systems, making it particularly relevant to scientists interested in human disease, especially cancer. Importantly, well proved methods for studying cell growth are supplemented by some novel approaches, e.g., studies of cell cycle checkpoints, cell spheroids, and nuclear architecture. Only two chapters have been retained, in an updated form from Cell Growth and Apoptosis, the predecessor volume. The book is written by a team of scientists highly experienced in procedures they describe, and offer details and hints found valuable in their own laboratories; thus, variants of the same general methods can be found in different chapters. These should be helpful to beginning as well as experienced investigators, and are designed to stimulate new approaches to old and new questions.

Published
1999

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