2,121 results on '"Georgiadis, P."'
Search Results
2. Absence of anomalous dissipation for weak solutions of the Maxwell--Stefan system
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Berselli, Luigi C., Georgiadis, Stefanos, and Tzavaras, Athanasios E.
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Mathematics - Analysis of PDEs - Abstract
In this paper we give a short and self-contained proof of the fact that weak solutions to the Maxwell-Stefan system automatically satisfy an entropy equality, establishing the absence of anomalous dissipation.
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- 2024
3. Adaptive estimation of the $\mathbb{L}_2$-norm of a probability density and related topics II. Upper bounds via the oracle approach
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Cleanthous, Galatia, Georgiadis, Athanasios G., and Lepski, Oleg V.
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Mathematics - Statistics Theory ,62G05, 62G20 - Abstract
This is the second part of the research project initiated in Cleanthous et al (2024). We deal with the problem of the adaptive estimation of the $\mathbb{L}_2$-norm of a probability density on $\mathbb{R}^d$, $d\geq 1$, from independent observations. The unknown density is assumed to be uniformly bounded by unknown constant and to belong to the union of balls in the isotropic/anisotropic Nikolskii's spaces. In Cleanthous et al (2024) we have proved that the optimally adaptive estimators do no exist in the considered problem and provided with several lower bounds for the adaptive risk. In this part we show that these bounds are tight and present the adaptive estimator which is obtained by a data-driven selection from a family of kernel-based estimators. The proposed estimation procedure as well as the computation of its risk are heavily based on new concentration inequalities for decoupled $U$-statistics of order two established in Section 4. It is also worth noting that all our results are derived from the unique oracle inequality which may be of independent interest.
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- 2024
4. Adaptive estimation of $\mathbb{L}_2$-norm of a probability density and related topics I. Lower bounds
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Cleanthous, Galatia, Georgiadis, Athanasios G., and Lepski, Oleg V.
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Mathematics - Statistics Theory ,62G05, 62G20 - Abstract
We deal with the problem of the adaptive estimation of the $\mathbb{L}_2$-norm of a probability density on $\mathbb{R}^d$, $d\geq 1$, from independent observations. The unknown density is assumed to be uniformly bounded and to belong to the union of balls in the isotropic/anisotropic Nikolskii's spaces. We will show that the optimally adaptive estimators over the collection of considered functional classes do no exist. Also, in the framework of an abstract density model we present several generic lower bounds related to the adaptive estimation of an arbitrary functional of a probability density. These results having independent interest have no analogue in the existing literature. In the companion paper Cleanthous et al (2024) we prove that established lower bounds are tight and provide with explicit construction of adaptive estimators of $\mathbb{L}_2$-norm of the density.
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- 2024
5. Neurostructural subgroup in 4291 individuals with schizophrenia identified using the subtype and stage inference algorithm.
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Jiang, Yuchao, Luo, Cheng, Wang, Jijun, Palaniyappan, Lena, Chang, Xiao, Xiang, Shitong, Zhang, Jie, Duan, Mingjun, Huang, Huan, Gaser, Christian, Nemoto, Kiyotaka, Miura, Kenichiro, Hashimoto, Ryota, Westlye, Lars, Richard, Genevieve, Fernandez-Cabello, Sara, Parker, Nadine, Andreassen, Ole, Kircher, Tilo, Nenadić, Igor, Stein, Frederike, Thomas-Odenthal, Florian, Teutenberg, Lea, Usemann, Paula, Dannlowski, Udo, Hahn, Tim, Grotegerd, Dominik, Meinert, Susanne, Lencer, Rebekka, Tang, Yingying, Zhang, Tianhong, Li, Chunbo, Yue, Weihua, Zhang, Yuyanan, Yu, Xin, Zhou, Enpeng, Lin, Ching-Po, Tsai, Shih-Jen, Rodrigue, Amanda, Glahn, David, Pearlson, Godfrey, Blangero, John, Karuk, Andriana, Pomarol-Clotet, Edith, Salvador, Raymond, Fuentes-Claramonte, Paola, Garcia-León, María, Spalletta, Gianfranco, Piras, Fabrizio, Vecchio, Daniela, Banaj, Nerisa, Cheng, Jingliang, Liu, Zhening, Yang, Jie, Gonul, Ali, Uslu, Ozgul, Burhanoglu, Birce, Uyar Demir, Aslihan, Rootes-Murdy, Kelly, Calhoun, Vince, Sim, Kang, Green, Melissa, Quidé, Yann, Chung, Young, Kim, Woo-Sung, Sponheim, Scott, Demro, Caroline, Ramsay, Ian, Iasevoli, Felice, de Bartolomeis, Andrea, Barone, Annarita, Ciccarelli, Mariateresa, Brunetti, Arturo, Cocozza, Sirio, Pontillo, Giuseppe, Tranfa, Mario, Park, Min, Kirschner, Matthias, Georgiadis, Foivos, Kaiser, Stefan, Van Rheenen, Tamsyn, Rossell, Susan, Hughes, Matthew, Woods, William, Carruthers, Sean, Sumner, Philip, Ringin, Elysha, Spaniel, Filip, Skoch, Antonin, Tomecek, David, Homan, Philipp, Homan, Stephanie, Omlor, Wolfgang, Cecere, Giacomo, Nguyen, Dana, Preda, Adrian, Thomopoulos, Sophia, Jahanshad, Neda, Cui, Long-Biao, and Yao, Dezhong
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Humans ,Schizophrenia ,Male ,Female ,Adult ,Algorithms ,Magnetic Resonance Imaging ,Gray Matter ,Machine Learning ,Middle Aged ,Brain ,Cross-Sectional Studies ,Europe ,Neuroimaging ,Reproducibility of Results ,North America ,Hippocampus - Abstract
Machine learning can be used to define subtypes of psychiatric conditions based on shared biological foundations of mental disorders. Here we analyzed cross-sectional brain images from 4,222 individuals with schizophrenia and 7038 healthy subjects pooled across 41 international cohorts from the ENIGMA, non-ENIGMA cohorts and public datasets. Using the Subtype and Stage Inference (SuStaIn) algorithm, we identify two distinct neurostructural subgroups by mapping the spatial and temporal trajectory of gray matter change in schizophrenia. Subgroup 1 was characterized by an early cortical-predominant loss with enlarged striatum, whereas subgroup 2 displayed an early subcortical-predominant loss in the hippocampus, striatum and other subcortical regions. We confirmed the reproducibility of the two neurostructural subtypes across various sample sites, including Europe, North America and East Asia. This imaging-based taxonomy holds the potential to identify individuals with shared neurobiological attributes, thereby suggesting the viability of redefining existing disorder constructs based on biological factors.
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- 2024
6. Connectome architecture shapes large-scale cortical alterations in schizophrenia: a worldwide ENIGMA study.
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Georgiadis, Foivos, Larivière, Sara, Glahn, David, Hong, L, Kochunov, Peter, Mowry, Bryan, Loughland, Carmel, Pantelis, Christos, Henskens, Frans, Green, Melissa, Cairns, Murray, Michie, Patricia, Rasser, Paul, Catts, Stanley, Tooney, Paul, Scott, Rodney, Schall, Ulrich, Carr, Vaughan, Quidé, Yann, Krug, Axel, Stein, Frederike, Nenadić, Igor, Brosch, Katharina, Kircher, Tilo, Gur, Raquel, Gur, Ruben, Satterthwaite, Theodore, Karuk, Andriana, Pomarol-Clotet, Edith, Radua, Joaquim, Fuentes-Claramonte, Paola, Salvador, Raymond, Spalletta, Gianfranco, Voineskos, Aristotle, Sim, Kang, Crespo-Facorro, Benedicto, Tordesillas Gutiérrez, Diana, Ehrlich, Stefan, Crossley, Nicolas, Grotegerd, Dominik, Repple, Jonathan, Lencer, Rebekka, Dannlowski, Udo, Calhoun, Vince, Rootes-Murdy, Kelly, Demro, Caroline, Ramsay, Ian, Sponheim, Scott, Schmidt, Andre, Borgwardt, Stefan, Tomyshev, Alexander, Lebedeva, Irina, Höschl, Cyril, Spaniel, Filip, Preda, Adrian, Nguyen, Dana, Uhlmann, Anne, Stein, Dan, Howells, Fleur, Temmingh, Henk, Diaz Zuluaga, Ana, López Jaramillo, Carlos, Iasevoli, Felice, Ji, Ellen, Homan, Stephanie, Omlor, Wolfgang, Homan, Philipp, Kaiser, Stefan, Seifritz, Erich, Misic, Bratislav, Valk, Sofie, Thompson, Paul, Van Erp, Theodorus, Turner, Jessica, Bernhardt, Boris, and Kirschner, Matthias
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Humans ,Schizophrenia ,Connectome ,Adult ,Female ,Male ,Magnetic Resonance Imaging ,Cerebral Cortex ,Nerve Net ,Brain ,Middle Aged ,Neural Pathways ,Young Adult - Abstract
Schizophrenia is a prototypical network disorder with widespread brain-morphological alterations, yet it remains unclear whether these distributed alterations robustly reflect the underlying network layout. We tested whether large-scale structural alterations in schizophrenia relate to normative structural and functional connectome architecture, and systematically evaluated robustness and generalizability of these network-level alterations. Leveraging anatomical MRI scans from 2439 adults with schizophrenia and 2867 healthy controls from 26 ENIGMA sites and normative data from the Human Connectome Project (n = 207), we evaluated structural alterations of schizophrenia against two network susceptibility models: (i) hub vulnerability, which examines associations between regional network centrality and magnitude of disease-related alterations; (ii) epicenter mapping, which identifies regions whose typical connectivity profile most closely resembles the disease-related morphological alterations. To assess generalizability and specificity, we contextualized the influence of site, disease stages, and individual clinical factors and compared network associations of schizophrenia with that found in affective disorders. Our findings show schizophrenia-related cortical thinning is spatially associated with functional and structural hubs, suggesting that highly interconnected regions are more vulnerable to morphological alterations. Predominantly temporo-paralimbic and frontal regions emerged as epicenters with connectivity profiles linked to schizophrenias alteration patterns. Findings were robust across sites, disease stages, and related to individual symptoms. Moreover, transdiagnostic comparisons revealed overlapping epicenters in schizophrenia and bipolar, but not major depressive disorder, suggestive of a pathophysiological continuity within the schizophrenia-bipolar-spectrum. In sum, cortical alterations over the course of schizophrenia robustly follow brain network architecture, emphasizing marked hub susceptibility and temporo-frontal epicenters at both the level of the group and the individual. Subtle variations of epicenters across disease stages suggest interacting pathological processes, while associations with patient-specific symptoms support additional inter-individual variability of hub vulnerability and epicenters in schizophrenia. Our work outlines potential pathways to better understand macroscale structural alterations, and inter- individual variability in schizophrenia.
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- 2024
7. A Note on Asynchronous Challenges: Unveiling Formulaic Bias and Data Loss in the Hayashi-Yoshida Estimator
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Georgiadis, Evangelos
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Statistics - Machine Learning ,Computer Science - Machine Learning ,Mathematics - Combinatorics ,Mathematics - Probability - Abstract
The Hayashi-Yoshida (\HY)-estimator exhibits an intrinsic, telescoping property that leads to an often overlooked computational bias, which we denote,formulaic or intrinsic bias. This formulaic bias results in data loss by cancelling out potentially relevant data points, the nonextant data points. This paper attempts to formalize and quantify the data loss arising from this bias. In particular, we highlight the existence of nonextant data points via a concrete example, and prove necessary and sufficient conditions for the telescoping property to induce this type of formulaic bias.Since this type of bias is nonexistent when inputs, i.e., observation times, $\Pi^{(1)} :=(t_i^{(1)})_{i=0,1,\ldots}$ and $\Pi^{(2)} :=(t_j^{(2)})_{j=0,1,\ldots}$, are synchronous, we introduce the (a,b)-asynchronous adversary. This adversary generates inputs $\Pi^{(1)}$ and $\Pi^{(2)}$ according to two independent homogenous Poisson processes with rates a>0 and b>0, respectively. We address the foundational questions regarding cumulative minimal (or least) average data point loss, and determine the values for a and b. We prove that for equal rates a=b, the minimal average cumulative data loss over both inputs is attained and amounts to 25\%. We present an algorithm, which is based on our theorem, for computing the exact number of nonextant data points given inputs $\Pi^{(1)}$ and $\Pi^{(2)}$, and suggest alternative methods. Finally, we use simulated data to empirically compare the (cumulative) average data loss of the (\HY)-estimator., Comment: submitted. 15 pages, 1 appendix, 4 figures, 1 table, 1 algo
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- 2024
8. Organizational Resilience through the Philosophical Lens of Aristotelian and Heraclitean Philosophy
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Georgiadis, Vasileios and Sarigiannidis, Lazaros
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- 2024
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9. Safety, structure and function five years after hESC-RPE patch transplantation in acute neovascular AMD with submacular haemorrhage
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Soomro, Taha, Georgiadis, Odysseus, Coffey, Peter J., and da Cruz, Lyndon
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- 2024
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10. Structural brain abnormalities and aggressive behaviour in schizophrenia: Mega-analysis of data from 2095 patients and 2861 healthy controls via the ENIGMA consortium
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Lamsma, Jelle, Raine, Adrian, Kia, Seyed M, Cahn, Wiepke, Arold, Dominic, Banaj, Nerisa, Barone, Annarita, Brosch, Katharina, Brouwer, Rachel, Brunetti, Arturo, Calhoun, Vince D, Chew, Qian H, Choi, Sunah, Chung, Young-Chul, Ciccarelli, Mariateresa, Cobia, Derin, Cocozza, Sirio, Dannlowski, Udo, Dazzan, Paola, de Bartolomeis, Andrea, Di Forti, Marta, Dumais, Alexandre, Edmond, Jesse T, Ehrlich, Stefan, Evermann, Ulrika, Flinkenflügel, Kira, Georgiadis, Foivos, Glahn, David C, Goltermann, Janik, Green, Melissa J, Grotegerd, Dominik, Guerrero-Pedraza, Amalia, Ha, Minji, Hong, Elliot L, Pol, Hilleke Hulshoff, Iasevoli, Felice, Kaiser, Stefan, Kaleda, Vasily, Karuk, Andriana, Kim, Minah, Kircher, Tilo, Kirschner, Matthias, Kochunov, Peter, Kwon, Jun Soo, Lebedeva, Irina, Lencer, Rebekka, Marques, Tiago R, Meinert, Susanne, Murray, Robin, Nenadić, Igor, Nguyen, Dana, Pearlson, Godfrey, Piras, Fabrizio, Pomarol-Clotet, Edith, Pontillo, Giuseppe, Potvin, Stéphane, Preda, Adrian, Quidé, Yann, Rodrigue, Amanda, Rootes-Murdy, Kelly, Salvador, Raymond, Skoch, Antonin, Sim, Kang, Spalletta, Gianfranco, Spaniel, Filip, Stein, Frederike, Thomas-Odenthal, Florian, Tikàsz, Andràs, Tomecek, David, Tomyshev, Alexander, Tranfa, Mario, Tsogt, Uyanga, Turner, Jessica A, van Erp, Theo GM, van Haren, Neeltje EM, van Os, Jim, Vecchio, Daniela, Wang, Lei, Wroblewski, Adrian, and Nickl-Jockschat, Thomas
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Biological Psychology ,Pharmacology and Pharmaceutical Sciences ,Biomedical and Clinical Sciences ,Psychology ,Schizophrenia ,Brain Disorders ,Neurosciences ,Biomedical Imaging ,Serious Mental Illness ,Mental Health ,Mental Illness ,Mental health - Abstract
BACKGROUND: Schizophrenia is associated with an increased risk of aggressive behaviour, which may partly be explained by illness-related changes in brain structure. However, previous studies have been limited by group-level analyses, small and selective samples of inpatients and long time lags between exposure and outcome. METHODS: This cross-sectional study pooled data from 20 sites participating in the international ENIGMA-Schizophrenia Working Group. Sites acquired T1-weighted and diffusion-weighted magnetic resonance imaging scans in a total of 2095 patients with schizophrenia and 2861 healthy controls. Measures of grey matter volume and white matter microstructural integrity were extracted from the scans using harmonised protocols. For each measure, normative modelling was used to calculate how much patients deviated (in z-scores) from healthy controls at the individual level. Ordinal regression models were used to estimate the associations of these deviations with concurrent aggressive behaviour (as odds ratios [ORs] with 99% confidence intervals [CIs]). Mediation analyses were performed for positive symptoms (i.e., delusions, hallucinations and disorganised thinking), impulse control and illness insight. Aggression and potential mediators were assessed with the Positive and Negative Syndrome Scale, Scale for the Assessment of Positive Symptoms or Brief Psychiatric Rating Scale. RESULTS: Aggressive behaviour was significantly associated with reductions in total cortical volume (OR [99% CI] = 0.88 [0.78, 0.98], p = .003) and global white matter integrity (OR [99% CI] = 0.72 [0.59, 0.88], p = 3.50 × 10-5) and additional reductions in dorsolateral prefrontal cortex volume (OR [99% CI] = 0.85 [0.74, 0.97], p =.002), inferior parietal lobule volume (OR [99% CI] = 0.76 [0.66, 0.87], p = 2.20 × 10-7) and internal capsule integrity (OR [99% CI] = 0.76 [0.63, 0.92], p = 2.90 × 10-4). Except for inferior parietal lobule volume, these associations were largely mediated by increased severity of positive symptoms and reduced impulse control. CONCLUSIONS: This study provides evidence that the co-occurrence of positive symptoms, poor impulse control and aggressive behaviour in schizophrenia has a neurobiological basis, which may inform the development of therapeutic interventions.
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- 2024
11. Spaces of distributions on product metric spaces associated with operators
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Georgiadis, Athanasios G., Kyriazis, George, and Petrushev, Pencho
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Mathematics - Functional Analysis ,Mathematics - Classical Analysis and ODEs - Abstract
We lay down the foundation of the theory of spaces of distributions on the product $X_1\times X_2$ of doubling metric measure spaces $X_1$, $X_2$ in the presence of non-negative self-adjoint operators $L_1$, $L_2$, whose heat kernels have Gaussian localization and the Markov property. This theory includes the development of two-parameter functional calculus induced by $L_1, L_2$, integral operators with highly localized kernels, test functions and distributions associated to $L_1, L_2$, spectral spaces accompanied by maximal Peetre and Nikolski type inequalities. Hardy spaces are developed in this two-parameter product setup. Two types of Besov and Triebel-Lizorkin spaces are introduced and studied: ordinary spaces and spaces with dominating mixed smoothness, with emphasis on the latter. Embedding results are obtained and spectral multiplies are developed.
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- 2023
12. Alignment via friction for nonisothermal multicomponent fluid systems
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Georgiadis, Stefanos and Tzavaras, Athanasios E.
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Mathematics - Analysis of PDEs ,Mathematical Physics - Abstract
The derivation of an approximate Class-I model for nonisothermal multicomponent systems of fluids, as the high-friction limit of a Class-II model is justified, by validating the Chapman-Enskog expansion performed from the Class-II model towards the Class-I model. The analysis proceeds by comparing two thermomechanical theories via relative entropy.
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- 2023
13. Renormalized solutions for the Maxwell--Stefan system with an application to uniqueness of weak solutions
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Georgiadis, Stefanos, Kim, Hoyoun, and Tzavaras, Athanasios E.
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Mathematics - Analysis of PDEs ,35D99, 35Q35, 76N10, 76R50, 76T30 - Abstract
We give conditions that guarantee uniqueness of renormalized solutions for the Maxwell-Stefan system. The proof is based on an identity for the evolution of the symmetrized relative entropy. Using the method of doubling the variables we derive the identity for two renormalized solutions and use information on the spectrum of the Maxwell-Stefan matrix to estimate the symmetrized relative entropy and show uniqueness. We then show that weak solutions for the Maxwell-Stefan system have sufficient regularity to produce renormalized solutions. Combining the two results yields a uniqueness result for weak solutions of the Maxwell-Stefan system with bounded fluxes.
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- 2023
14. $2$-Fault-Tolerant Strong Connectivity Oracles
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Georgiadis, Loukas, Kosinas, Evangelos, and Tsokaktsis, Daniel
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Computer Science - Data Structures and Algorithms - Abstract
We study the problem of efficiently answering strong connectivity queries under two vertex failures. Given a directed graph $G$ with $n$ vertices, we provide a data structure with $O(nh)$ space and $O(h)$ query time, where $h$ is the height of a decomposition tree of $G$ into strongly connected subgraphs. This immediately implies data structures with $O(n \log{n})$ space and $O(\log{n})$ query time for graphs of constant treewidth, and $O(n^{3/2})$ space and $O(\sqrt{n})$ query time for planar graphs. For general directed graphs, we give a refined version of our data structure that achieves $O(n\sqrt{m})$ space and $O(\sqrt{m})$ query time, where $m$ is the number of edges of the graph. We also provide some simple BFS-based heuristics that seem to work remarkably well in practice. In the experimental part, we first evaluate various methods to construct a decomposition tree with small height $h$ in practice. Then we provide efficient implementations of our data structures, and evaluate their empirical performance by conducting an extensive experimental study on graphs taken from real-world applications., Comment: Conference version to appear in the proceedings of ALENEX 2024
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- 2023
15. Cardiocondyla obscurior, a new alien ant in Crete (Hymenoptera, Formicidae)
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Schifani, Enrico, Georgiadis, Christos, and Menchetti, Mattia
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Greece ,exotic species ,Mediterranean islands ,Cardiocondyla wroughtonii group ,Myrmicinae - Abstract
We report for the first time the occurrence of the alien ant Cardiocondyla obscurior Wheeler, 1929 on the Greek island of Crete. Cardiocondyla obscurior is one of many congeneric taxa with worldwide success as tramp species, having attained a cosmopolitan distribution while having Indomalayan origins. It was first detected in Europe in 1999, and since 2015 it has started to be found outdoors in Southern European countries. Our record is the first in Europe in which the species is observed to be established outdoors in an agricultural area instead of an urban environment. Introduced Cardiocondyla ants are generally thought to have little ecological impact, although targeted studies have been lacking. Cardiocondyla obscurior is the third species of its genus to be found on the island of Crete, which is characterized by a remarkable ant diversity.
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- 2024
16. Highlighting overlooked biodiversity through online platforms: The 'Chalcid Wasps of Cyprus' website
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Evangelos Koutsoukos, Jakovos Demetriou, Christos Georgiadis, Mircea-Dan Mitroiu, Stephen Compton, and Angeliki Martinou
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awareness raising tool ,biodiversity ,Chalcidoidea ,Biology (General) ,QH301-705.5 - Abstract
Biodiversity data platforms including databases, websites and data repositories underpin conservation efforts by collecting spatiotemporal data of discovered native and alien species and maps of their distributions. Chalcid wasps (Hymenoptera, Chalcidoidea) are one of the most diverse insect groups estimated to include half a million species. Being mostly parasitoids of other arthropods, they have been successfully used as biological control agents against serious agricultural pests worldwide. In Cyprus, only 124 species of chalcid wasps have been recorded, with 53 species being alien to the island. Their true biodiversity is predicted to be much larger because the island is both under-sampled and under-researched. A number of biodiversity data platforms focusing on the biodiversity of Cyprus are currently online; however, an online platform dedicated on the chalcid wasps of Cyprus is lacking. In the framework of the Darwin Plus Fellowship (DPLUS202) “Species richness and biological invasions of Chalcid wasps in Akrotiri Peninsula”, the “Chalcid wasps of Cyprus” website (https://sites.google.com/view/chalcidwaspscyprus) is presented. This online, dynamic database aims to: (1) raise public awareness regarding a rather neglected and yet ecologically important insect group, (2) provide data on the morphology, ecology and biodiversity of Chalcidoidea on Cyprus, as well as (3) promote conservation needs by setting a baseline for the future assessment of both native and alien chalcid wasp species. This online platform will be regularly revised in order to provide an up-to-date, user-friendly digital environment to the scientific community, policy-makers and citizens.
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- 2024
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17. Proton exchange membrane-like alkaline water electrolysis using flow-engineered three-dimensional electrodes
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Fernando Rocha, Christos Georgiadis, Kevin Van Droogenbroek, Renaud Delmelle, Xavier Pinon, Grzegorz Pyka, Greet Kerckhofs, Franz Egert, Fatemeh Razmjooei, Syed-Asif Ansar, Shigenori Mitsushima, and Joris Proost
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Science - Abstract
Abstract For high rate water electrolysers, minimising Ohmic losses through efficient gas bubble evacuation away from the active electrode is as important as minimising activation losses by improving the electrode’s electrocatalytic properties. In this work, by a combined experimental and computational fluid dynamics (CFD) approach, we identify the topological parameters of flow-engineered 3-D electrodes that direct their performance towards enhanced bubble evacuation. In particular, we show that integrating Ni-based foam electrodes into a laterally-graded bi-layer zero-gap cell configuration allows for alkaline water electrolysis to become Proton Exchange Membrane (PEM)-like, even when keeping a state-of-the-art Zirfon diaphragm. Detailed CFD simulations, explicitly taking into account the entire 3-D electrode and cell topology, show that under a forced uniform upstream electrolyte flow, such a graded structure induces a high lateral velocity component in the direction normal to and away from the diaphragm. This work is therefore an invitation to start considering PEM-like cell designs for alkaline water electrolysis as well, in particular the use of square or rectangular electrodes in flow-through type electrochemical cells.
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- 2024
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18. Three results on the Energy conservation for the 3D Euler equations
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Berselli, Luigi C. and Georgiadis, Stefanos
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Mathematics - Analysis of PDEs ,Mathematical Physics - Abstract
We consider the 3D Euler equations for incompressible homogeneous fluids and we study the problem of energy conservation for weak solutions in the space-periodic case. First, we prove the energy conservation for a full scale of Besov spaces, by extending some classical results to a wider range of exponents. Next, we consider the energy conservation in the case of conditions on the gradient, recovering some results which were known, up to now, only for the Navier-Stokes equations and for weak solutions of the Leray-Hopf type. Finally, we make some remarks on the Onsager singularity problem, identifying conditions which allow to pass to the limit from solutions of the Navier-Stokes equations to solution of the Euler ones, producing weak solutions which are energy conserving.
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- 2023
19. Raster Interval Object Approximations for Spatial Intersection Joins
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Georgiadis, Thanasis, Zacharatou, Eleni Tzirita, and Mamoulis, Nikos
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Computer Science - Databases - Abstract
Spatial join processing techniques that identify intersections between complex geometries (e.g.,polygons) commonly follow a two-step filter-and-refine pipeline; the filter step evaluates the query predicate on the minimum bounding rectangles (MBRs) of objects and the refinement step eliminates false positives by applying the query on the exact geometries. We propose a raster intervals approximation of object geometries and introduce a powerful intermediate step in pipeline. In a preprocessing phase, our method (i) rasterizes each object geometry using a fine grid, (ii) models groups of nearby cells that intersect the polygon as an interval, and (iii) encodes each interval by a bitstring that captures the overlap of each cell in it with the polygon. Going one step further, we improve our approach to approximate each object by two sets of intervals that succintly capture the raster cells which (i) intersect with the object and (ii) are fully contained in the object. Using this representation, we show that we can verify whether two polygons intersect by a sequence of joins between the interval sets that take linear time. Our approximations can effectively be compressed and can be customized for use on partitioned data and polygons of varying sizes, rasterized at different granularities. Finally, we propose a novel algorithm that computes the interval approximation of a polygon without fully rasterizing it first, rendering the computation of approximations orders of magnitude faster. Experiments on real data demonstrate the effectiveness and efficiency of our proposal over previous work., Comment: 34 pages
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- 2023
20. TrickVOS: A Bag of Tricks for Video Object Segmentation
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Skartados, Evangelos, Georgiadis, Konstantinos, Yucel, Mehmet Kerim, Ioannis, Koskinas, Domi, Armando, Drosou, Anastasios, Manganelli, Bruno, and Saa-Garriga, Albert
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Computer Science - Computer Vision and Pattern Recognition - Abstract
Space-time memory (STM) network methods have been dominant in semi-supervised video object segmentation (SVOS) due to their remarkable performance. In this work, we identify three key aspects where we can improve such methods; i) supervisory signal, ii) pretraining and iii) spatial awareness. We then propose TrickVOS; a generic, method-agnostic bag of tricks addressing each aspect with i) a structure-aware hybrid loss, ii) a simple decoder pretraining regime and iii) a cheap tracker that imposes spatial constraints in model predictions. Finally, we propose a lightweight network and show that when trained with TrickVOS, it achieves competitive results to state-of-the-art methods on DAVIS and YouTube benchmarks, while being one of the first STM-based SVOS methods that can run in real-time on a mobile device., Comment: Accepted to ICIP 2023
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- 2023
21. Accelerated, physics-inspired inference of skeletal muscle microstructure from diffusion-weighted MRI
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Naughton, Noel, Cahoon, Stacey, Sutton, Brad, and Georgiadis, John G.
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Physics - Medical Physics ,Computer Science - Machine Learning - Abstract
Muscle health is a critical component of overall health and quality of life. However, current measures of skeletal muscle health take limited account of microstructural variations within muscle, which play a crucial role in mediating muscle function. To address this, we present a physics-inspired, machine learning-based framework for the non-invasive and in vivo estimation of microstructural organization in skeletal muscle from diffusion-weighted MRI (dMRI). To reduce the computational expense associated with direct numerical simulations of dMRI physics, a polynomial meta-model is developed that accurately represents the input/output relationships of a high-fidelity numerical model. This meta-model is used to develop a Gaussian process (GP) model to provide voxel-wise estimates and confidence intervals of microstructure organization in skeletal muscle. Given noise-free data, the GP model accurately estimates microstructural parameters. In the presence of noise, the diameter, intracellular diffusion coefficient, and membrane permeability are accurately estimated with narrow confidence intervals, while volume fraction and extracellular diffusion coefficient are poorly estimated and exhibit wide confidence intervals. A reduced-acquisition GP model, consisting of one-third the diffusion-encoding measurements, is shown to predict parameters with similar accuracy to the original model. The fiber diameter and volume fraction estimated by the reduced GP model is validated via histology, with both parameters within their associated confidence intervals, demonstrating the capability of the proposed framework as a promising non-invasive tool for assessing skeletal muscle health and function., Comment: 11 pages, 5 figures, 2 tables
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- 2023
22. Two neurostructural subtypes: results of machine learning on brain images from 4,291 individuals with schizophrenia
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Jiang, Yuchao, Luo, Cheng, Wang, Jijun, Palaniyappan, Lena, Chang, Xiao, Xiang, Shitong, Zhang, Jie, Duan, Mingjun, Huang, Huan, Gaser, Christian, Nemoto, Kiyotaka, Miura, Kenichiro, Hashimoto, Ryota, Westlye, Lars T, Richard, Genevieve, Fernandez-Cabello, Sara, Parker, Nadine, Andreassen, Ole A, Kircher, Tilo, Nenadić, Igor, Stein, Frederike, Thomas-Odenthal, Florian, Teutenberg, Lea, Usemann, Paula, Dannlowski, Udo, Hahn, Tim, Grotegerd, Dominik, Meinert, Susanne, Lencer, Rebekka, Tang, Yingying, Zhang, Tianhong, Li, Chunbo, Yue, Weihua, Zhang, Yuyanan, Yu, Xin, Zhou, Enpeng, Lin, Ching-Po, Tsai, Shih-Jen, Rodrigue, Amanda L, Glahn, David, Pearlson, Godfrey, Blangero, John, Karuk, Andriana, Pomarol-Clotet, Edith, Salvador, Raymond, Fuentes-Claramonte, Paola, Garcia-León, María Ángeles, Spalletta, Gianfranco, Piras, Fabrizio, Vecchio, Daniela, Banaj, Nerisa, Cheng, Jingliang, Liu, Zhening, Yang, Jie, Gonul, Ali Saffet, Uslu, Ozgul, Burhanoglu, Birce Begum, Demir, Aslihan Uyar, Rootes-Murdy, Kelly, Calhoun, Vince D, Sim, Kang, Green, Melissa, Quidé, Yann, Chung, Young Chul, Kim, Woo-Sung, Sponheim, Scott R, Demro, Caroline, Ramsay, Ian S, Iasevoli, Felice, de Bartolomeis, Andrea, Barone, Annarita, Ciccarelli, Mariateresa, Brunetti, Arturo, Cocozza, Sirio, Pontillo, Giuseppe, Tranfa, Mario, Park, Min Tae M, Kirschner, Matthias, Georgiadis, Foivos, Kaiser, Stefan, Van Rheenen, Tamsyn E, Rossell, Susan L, Hughes, Matthew, Woods, William, Carruthers, Sean P, Sumner, Philip, Ringin, Elysha, Spaniel, Filip, Skoch, Antonin, Tomecek, David, Homan, Philipp, Homan, Stephanie, Omlor, Wolfgang, Cecere, Giacomo, Nguyen, Dana D, Preda, Adrian, Thomopoulos, Sophia, Jahanshad, Neda, Cui, Long-Biao, and Yao, Dezhong
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Biological Psychology ,Biomedical and Clinical Sciences ,Psychology ,Machine Learning and Artificial Intelligence ,Mental Illness ,Clinical Research ,Brain Disorders ,Serious Mental Illness ,Neurosciences ,Schizophrenia ,Mental Health ,Behavioral and Social Science ,Biomedical Imaging ,Mental health ,Good Health and Well Being ,ENIGMA ,artificial intelligence ,brain gray matter ,schizophrenia ,structural MRI ,subtype - Abstract
Machine learning can be used to define subtypes of psychiatric conditions based on shared clinical and biological foundations, presenting a crucial step toward establishing biologically based subtypes of mental disorders. With the goal of identifying subtypes of disease progression in schizophrenia, here we analyzed cross-sectional brain structural magnetic resonance imaging (MRI) data from 4,291 individuals with schizophrenia (1,709 females, age=32.5 years±11.9) and 7,078 healthy controls (3,461 females, age=33.0 years±12.7) pooled across 41 international cohorts from the ENIGMA Schizophrenia Working Group, non-ENIGMA cohorts and public datasets. Using a machine learning approach known as Subtype and Stage Inference (SuStaIn), we implemented a brain imaging-driven classification that identifies two distinct neurostructural subgroups by mapping the spatial and temporal trajectory of gray matter (GM) loss in schizophrenia. Subgroup 1 (n=2,622) was characterized by an early cortical-predominant loss (ECL) with enlarged striatum, whereas subgroup 2 (n=1,600) displayed an early subcortical-predominant loss (ESL) in the hippocampus, amygdala, thalamus, brain stem and striatum. These reconstructed trajectories suggest that the GM volume reduction originates in the Broca's area/adjacent fronto-insular cortex for ECL and in the hippocampus/adjacent medial temporal structures for ESL. With longer disease duration, the ECL subtype exhibited a gradual worsening of negative symptoms and depression/anxiety, and less of a decline in positive symptoms. We confirmed the reproducibility of these imaging-based subtypes across various sample sites, independent of macroeconomic and ethnic factors that differed across these geographic locations, which include Europe, North America and East Asia. These findings underscore the presence of distinct pathobiological foundations underlying schizophrenia. This new imaging-based taxonomy holds the potential to identify a more homogeneous sub-population of individuals with shared neurobiological attributes, thereby suggesting the viability of redefining existing disorder constructs based on biological factors.
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- 2023
23. Proton exchange membrane-like alkaline water electrolysis using flow-engineered three-dimensional electrodes
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Rocha, Fernando, Georgiadis, Christos, Van Droogenbroek, Kevin, Delmelle, Renaud, Pinon, Xavier, Pyka, Grzegorz, Kerckhofs, Greet, Egert, Franz, Razmjooei, Fatemeh, Ansar, Syed-Asif, Mitsushima, Shigenori, and Proost, Joris
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- 2024
- Full Text
- View/download PDF
24. Author Correction: scCircle-seq unveils the diversity and complexity of extrachromosomal circular DNAs in single cells
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Chen, Jinxin Phaedo, Diekmann, Constantin, Wu, Honggui, Chen, Chong, Della Chiara, Giulia, Berrino, Enrico, Georgiadis, Konstantinos L., Bouwman, Britta A. M., Virdi, Mohit, Harbers, Luuk, Bellomo, Sara Erika, Marchiò, Caterina, Bienko, Magda, and Crosetto, Nicola
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- 2024
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25. scCircle-seq unveils the diversity and complexity of extrachromosomal circular DNAs in single cells
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Chen, Jinxin Phaedo, Diekmann, Constantin, Wu, Honggui, Chen, Chong, Della Chiara, Giulia, Berrino, Enrico, Georgiadis, Konstantinos L., Bouwman, Britta A. M., Virdi, Mohit, Harbers, Luuk, Bellomo, Sara Erika, Marchiò, Caterina, Bienko, Magda, and Crosetto, Nicola
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- 2024
- Full Text
- View/download PDF
26. Improving the surface quality of AlMgSi1 alloy with the selection of the appropriate vibration grinding stones
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Engler, Carsten, Georgiadis, Anthimos, Lange, Dirk, and Meier, Nicolas
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- 2024
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27. Abbreviated Dialectical Behavior Therapy Virtual Skills Group for Caregivers of Adolescents: An Exploratory Study of Service User and Clinical Outcomes
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Hare, Megan, Conroy, Kristina, Georgiadis, Christopher, and Shaw, Ashley M.
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- 2024
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28. The Swiss Spinal Cord Injury Cohort Study (SwiSCI) biobank: from concept to reality
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Zeh, Ramona M., Glisic, Marija, Capossela, Simona, Bertolo, Alessandro, Valido, Ezra, Jordan, Xavier, Hund-Georgiadis, Margret, Pannek, Jürgen, Eriks-Hoogland, Inge, Stucki, Gerold, and Stoyanov, Jivko
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- 2024
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29. Establishing the link: Does web traffic from various marketing channels influence direct traffic source purchases?
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Filippou, Georgios, Georgiadis, Athanasios G., and Jha, Ashish Kumar
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- 2024
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30. Pointwise density estimation on metric spaces and applications in seismology
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Cleanthous, G., Georgiadis, Athanasios G., and White, P. A.
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- 2024
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31. A Fractional Viscoelastic Model Of The Axon In Brain White Matter
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Pasupathy, Parameshwaran, Georgiadis, John G, and Pelegri, Assimina A
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Physics - Applied Physics - Abstract
Traumatic axonal injury occurs when loads experienced on the tissue-scale are transferred to the individual axons. Mechanical characterization of axon deformation especially under dynamic loads however is extremely difficult owing to their viscoelastic properties. The viscoelastic characterization of axon properties that are based on interpretation of results from in-vivo brain Magnetic Resonance Elastography (MRE) are dependent on the specific frequencies used to generate shear waves with which measurements are made. In this study, we aim to develop a fractional viscoelastic model to characterize the time dependent behavior of the properties of the axons in a composite white matter (WM) model. The viscoelastic powerlaw behavior observed at the tissue level is assumed to exist across scales, from the continuum macroscopic level to that of the microstructural realm of the axons. The material parameters of the axons and glia are fitted to a springpot model. The 3D fractional viscoelastic springpot model is implemented within a finite element framework. The constitutive equations defining the fractional model are coded using a vectorized user defined material (VUMAT) subroutine in ABAQUS finite element software. Using this material characterization, representative volume elements (RVE) of axons embedded in glia with periodic boundary conditions are developed and subjected to a relaxation displacement boundary condition. The homogenized orthotropic fractional material properties of the axon-matrix system as a function of the volume fraction of axons in the ECM are extracted by solving the inverse problem., Comment: Accepted for publication at the 12th International Conference on Mathematical Modeling in Physical Sciences
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- 2023
32. Pointwise density estimation on metric spaces and applications in seismology
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Cleanthous, Galatia, Georgiadis, Athanasios G., and White, Philip A.
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Mathematics - Statistics Theory ,Statistics - Applications - Abstract
We are studying the problem of estimating density in a wide range of metric spaces, including the Euclidean space, the sphere, the ball, and various Riemannian manifolds. Our framework involves a metric space with a doubling measure and a self-adjoint operator, whose heat kernel exhibits Gaussian behaviour. We begin by reviewing the construction of kernel density estimators and the related background information. As a novel result, we present a pointwise kernel density estimation for probability density functions that belong to general H\"{o}lder spaces. The study is accompanied by an application in Seismology. Precisely, we analyze a globally-indexed dataset of earthquake occurrence and compare the out-of-sample performance of several approximated kernel density estimators indexed on the sphere.
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- 2023
33. Global existence of weak solutions and weak-strong uniqueness for nonisothermal Maxwell-Stefan systems
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Georgiadis, Stefanos and Jüngel, Ansgar
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Mathematics - Analysis of PDEs - Abstract
The dynamics of multicomponent gas mixtures with vanishing barycentric velocity is described by Maxwell-Stefan equations with mass diffusion and heat conduction. The equations consist of the mass and energy balances, coupled to an algebraic system that relates the partial velocities and driving forces. The global existence of weak solutions to this system in a bounded domain with no-flux boundary conditions is proved by using the boundedness-by-entropy method. A priori estimates are obtained from the entropy inequality which originates from the consistent thermodynamic modeling. Furthermore, the weak-strong uniqueness property is shown by using the relative entropy method.
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- 2023
34. LP-IOANet: Efficient High Resolution Document Shadow Removal
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Georgiadis, Konstantinos, Yucel, M. Kerim, Skartados, Evangelos, Dimaridou, Valia, Drosou, Anastasios, Saa-Garriga, Albert, and Manganelli, Bruno
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Computer Science - Computer Vision and Pattern Recognition - Abstract
Document shadow removal is an integral task in document enhancement pipelines, as it improves visibility, readability and thus the overall quality. Assuming that the majority of practical document shadow removal scenarios require real-time, accurate models that can produce high-resolution outputs in-the-wild, we propose Laplacian Pyramid with Input/Output Attention Network (LP-IOANet), a novel pipeline with a lightweight architecture and an upsampling module. Furthermore, we propose three new datasets which cover a wide range of lighting conditions, images, shadow shapes and viewpoints. Our results show that we outperform the state-of-the-art by a 35% relative improvement in mean average error (MAE), while running real-time in four times the resolution (of the state-of-the-art method) on a mobile device., Comment: ICASSP 2023
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- 2023
35. On 2-strong connectivity orientations of mixed graphs and related problems
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Georgiadis, Loukas, Kefallinos, Dionysios, and Kosinas, Evangelos
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Computer Science - Data Structures and Algorithms ,Mathematics - Combinatorics - Abstract
A mixed graph $G$ is a graph that consists of both undirected and directed edges. An orientation of $G$ is formed by orienting all the undirected edges of $G$, i.e., converting each undirected edge $\{u,v\}$ into a directed edge that is either $(u,v)$ or $(v,u)$. The problem of finding an orientation of a mixed graph that makes it strongly connected is well understood and can be solved in linear time. Here we introduce the following orientation problem in mixed graphs. Given a mixed graph $G$, we wish to compute its maximal sets of vertices $C_1,C_2,\ldots,C_k$ with the property that by removing any edge $e$ from $G$ (directed or undirected), there is an orientation $R_i$ of $G\setminus{e}$ such that all vertices in $C_i$ are strongly connected in $R_i$. We discuss properties of those sets, and we show how to solve this problem in linear time by reducing it to the computation of the $2$-edge twinless strongly connected components of a directed graph. A directed graph $G=(V,E)$ is twinless strongly connected if it contains a strongly connected spanning subgraph without any pair of antiparallel (or twin) edges. The twinless strongly connected components (TSCCs) of a directed graph $G$ are its maximal twinless strongly connected subgraphs. A $2$-edge twinless strongly connected component (2eTSCC) of $G$ is a maximal subset of vertices $C$ such that any two vertices $u, v \in C$ are in the same twinless strongly connected component of $G \setminus e$, for any edge $e$. These concepts are motivated by several diverse applications, such as the design of road and telecommunication networks, and the structural stability of buildings.
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- 2023
36. Neurostructural subgroup in 4291 individuals with schizophrenia identified using the subtype and stage inference algorithm
- Author
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Yuchao Jiang, Cheng Luo, Jijun Wang, Lena Palaniyappan, Xiao Chang, Shitong Xiang, Jie Zhang, Mingjun Duan, Huan Huang, Christian Gaser, Kiyotaka Nemoto, Kenichiro Miura, Ryota Hashimoto, Lars T. Westlye, Genevieve Richard, Sara Fernandez-Cabello, Nadine Parker, Ole A. Andreassen, Tilo Kircher, Igor Nenadić, Frederike Stein, Florian Thomas-Odenthal, Lea Teutenberg, Paula Usemann, Udo Dannlowski, Tim Hahn, Dominik Grotegerd, Susanne Meinert, Rebekka Lencer, Yingying Tang, Tianhong Zhang, Chunbo Li, Weihua Yue, Yuyanan Zhang, Xin Yu, Enpeng Zhou, Ching-Po Lin, Shih-Jen Tsai, Amanda L. Rodrigue, David Glahn, Godfrey Pearlson, John Blangero, Andriana Karuk, Edith Pomarol-Clotet, Raymond Salvador, Paola Fuentes-Claramonte, María Ángeles Garcia-León, Gianfranco Spalletta, Fabrizio Piras, Daniela Vecchio, Nerisa Banaj, Jingliang Cheng, Zhening Liu, Jie Yang, Ali Saffet Gonul, Ozgul Uslu, Birce Begum Burhanoglu, Aslihan Uyar Demir, Kelly Rootes-Murdy, Vince D. Calhoun, Kang Sim, Melissa Green, Yann Quidé, Young Chul Chung, Woo-Sung Kim, Scott R. Sponheim, Caroline Demro, Ian S. Ramsay, Felice Iasevoli, Andrea de Bartolomeis, Annarita Barone, Mariateresa Ciccarelli, Arturo Brunetti, Sirio Cocozza, Giuseppe Pontillo, Mario Tranfa, Min Tae M. Park, Matthias Kirschner, Foivos Georgiadis, Stefan Kaiser, Tamsyn E. Van Rheenen, Susan L. Rossell, Matthew Hughes, William Woods, Sean P. Carruthers, Philip Sumner, Elysha Ringin, Filip Spaniel, Antonin Skoch, David Tomecek, Philipp Homan, Stephanie Homan, Wolfgang Omlor, Giacomo Cecere, Dana D. Nguyen, Adrian Preda, Sophia I. Thomopoulos, Neda Jahanshad, Long-Biao Cui, Dezhong Yao, Paul M. Thompson, Jessica A. Turner, Theo G. M. van Erp, Wei Cheng, ENIGMA Schizophrenia Consortium, Jianfeng Feng, and ZIB Consortium
- Subjects
Science - Abstract
Abstract Machine learning can be used to define subtypes of psychiatric conditions based on shared biological foundations of mental disorders. Here we analyzed cross-sectional brain images from 4,222 individuals with schizophrenia and 7038 healthy subjects pooled across 41 international cohorts from the ENIGMA, non-ENIGMA cohorts and public datasets. Using the Subtype and Stage Inference (SuStaIn) algorithm, we identify two distinct neurostructural subgroups by mapping the spatial and temporal ‘trajectory’ of gray matter change in schizophrenia. Subgroup 1 was characterized by an early cortical-predominant loss with enlarged striatum, whereas subgroup 2 displayed an early subcortical-predominant loss in the hippocampus, striatum and other subcortical regions. We confirmed the reproducibility of the two neurostructural subtypes across various sample sites, including Europe, North America and East Asia. This imaging-based taxonomy holds the potential to identify individuals with shared neurobiological attributes, thereby suggesting the viability of redefining existing disorder constructs based on biological factors.
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- 2024
- Full Text
- View/download PDF
37. Alignment via Friction for Nonisothermal Multicomponent Fluid Systems
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Georgiadis, Stefanos and Tzavaras, Athanasios E.
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- 2024
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38. Three results on the energy conservation for the 3D Euler equations
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Berselli, Luigi C. and Georgiadis, Stefanos
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- 2024
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39. Correction: Development of an optimized AAV2/5 gene therapy vector for Leber congenital amaurosis owing to defects in RPE65
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Georgiadis, A., Duran, Y., Ribeiro, J., Abelleira-Hervas, L., Robbie, S. J., Sünkel-Laing, B., Fourali, S., Gonzalez-Cordero, A., Cristante, E., Michaelides, M., Bainbridge, J. W. B., Smith, A. J., and Ali, R. R.
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- 2024
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40. Gamification Design Patterns for User Engagement
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Triantafyllou, Serafeim A. and Georgiadis, Christos K.
- Abstract
The rapid development of technology in today's times make business' survival a rather complex task. It is therefore necessary for the specialized organization and administration of each company to differentiate and strengthen its competitive advantages. Gamification is an established practice in many business domains and can enforce employees to engage in business processes and change aspects of their behavior. Even though numerous gamification patterns that are described in literature have been used so far by businesses to various working environments, the outcomes were not the best possible that we would expect in terms of their right utilization to business non-game contexts. Thus, there is need for concise gamification patterns that can offer right guidance to game designers in business. Gamification design patterns can provide a distilled knowledge of techniques of how to design object-oriented software. This paper aims to address this gap in existing literature by describing new gamification design patterns, classifying them according to specific criteria and providing new information to this research domain. Our study is a descriptive literature review and is based on review of previous works. This descriptive literature review tries to give a better understanding by proposing new gamification design patterns in the continuously evolving research domain of gamification design patterns.
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- 2022
41. Non-isothermal multicomponent flows with mass diffusion and heat conduction
- Author
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Georgiadis, Stefanos, Jüngel, Ansgar, and Tzavaras, Athanasios
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Mathematics - Analysis of PDEs - Abstract
A type-I model of non-isothermal multicomponent systems of gases describing mass diffusive and heat conductive phenomena is presented. The derivation of the model and a convergence result among thermomechanical theories in the smooth regime are discussed. Furthermore, the global-in-time existence of weak solutions and the weak-strong uniqueness property are established for the corresponding system with zero barycentric velocity., Comment: Submitted to the Proceedings of XVIII International Conference on Hyperbolic Problems: Theory, Numerics, Applications (HYP2022)
- Published
- 2023
42. Asynchronously Trained Distributed Topographic Maps
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Siddiqui, Abbas and Georgiadis, Dionysios
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Computer Science - Machine Learning ,Computer Science - Artificial Intelligence ,Computer Science - Neural and Evolutionary Computing ,I.2 ,I.4 - Abstract
Topographic feature maps are low dimensional representations of data, that preserve spatial dependencies. Current methods of training such maps (e.g. self organizing maps - SOM, generative topographic maps) require centralized control and synchronous execution, which restricts scalability. We present an algorithm that uses $N$ autonomous units to generate a feature map by distributed asynchronous training. Unit autonomy is achieved by sparse interaction in time \& space through the combination of a distributed heuristic search, and a cascade-driven weight updating scheme governed by two rules: a unit i) adapts when it receives either a sample, or the weight vector of a neighbor, and ii) broadcasts its weight vector to its neighbors after adapting for a predefined number of times. Thus, a vector update can trigger an avalanche of adaptation. We map avalanching to a statistical mechanics model, which allows us to parametrize the statistical properties of cascading. Using MNIST, we empirically investigate the effect of the heuristic search accuracy and the cascade parameters on map quality. We also provide empirical evidence that algorithm complexity scales at most linearly with system size $N$. The proposed approach is found to perform comparably with similar methods in classification tasks across multiple datasets., Comment: 11 Pages, 8 Figures
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- 2023
43. On maximal k-edge-connected subgraphs of undirected graphs
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Georgiadis, Loukas, Italiano, Giuseppe F., Kosinas, Evangelos, and Pattanayak, Debasish
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Computer Science - Data Structures and Algorithms - Abstract
We show how to find and efficiently maintain maximal k-edge-connected subgraphs in undirected graphs. In particular, we provide the following results. (1) A general framework for maintaining the maximal k-edge-connected subgraphs upon insertions of edges or vertices, by successively partitioning the graph into its k-edge-connected components. This defines a decomposition tree, which can be maintained by using algorithms for the incremental maintenance of the k-edge-connected components as black boxes at every level of the tree. (2) As an application of this framework, we provide two algorithms for the incremental maintenance of the maximal $3$-edge-connected subgraphs. These algorithms allow for vertex and edge insertions, interspersed with queries asking whether two vertices belong to the same maximal $3$-edge-connected subgraph. The first algorithm has $O(m\alpha(m,n) + n^2\log^2 n)$ total running time and uses $O(n)$ space, where $m$ is the number of edge insertions and queries, and $n$ is the total number of vertices inserted. The second algorithm performs the same operations in faster $O(m\alpha(m,n) + n^2\alpha(n,n))$ time in total, using $O(n^2)$ space. (3) We provide efficient constructions of sparse subgraphs that have the same maximal k-edge-connected subgraphs as the original graph. These are useful in speeding up computations involving the maximal k-edge-connected subgraphs in dense undirected graphs. (4) We give two deterministic algorithms for computing the maximal k-edge-connected subgraphs in undirected graphs, with running times $O(m+k^{O(1)}n\sqrt{n}\mathrm{polylog}(n))$ and $O(m+k^{O(k)}n\sqrt{n}\log{n})$, respectively. (5) A fully dynamic algorithm for maintaining information about the maximal k-edge-connected subgraphs for fixed k. Our update bounds are $O(n\sqrt{n}\log{n})$ worst-case time, and we achieve constant time for maximal k-edge-connected subgraph queries.
- Published
- 2022
44. Holocene alluvial dynamics, soil erosion and settlement in the uplands of Macedonia (Greece): New geoarchaeological insights from Xerolakkos in Grevena
- Author
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Giannis Apostolou, Alfredo Mayoral, Konstantina Venieri, Sofia Dimaki, Arnau Garcia-Molsosa, Mercourios Georgiadis, and Hector A. Orengo
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Soil erosion ,Socio-environmental interaction ,Alluvial geoarchaeology ,Holocene rapid climatic changes (RCC) ,8.2 kyr BP event ,Ancient Macedonia ,Geography. Anthropology. Recreation ,Archaeology ,CC1-960 - Abstract
This paper addresses the interplay between Holocene landscape evolution and human settlement dynamics, drawing new evidence from the alluvial history of Xerolakkos, a continental stream in Grevena (Western Macedonia, Greece). We developed an integrated geoarchaeological survey combining remote sensing geomorphological mapping, litho-stratigraphic analysis and radiocarbon dating with the site evidence of a new archaeological survey. Results revealed four major alluviation phases, corresponding to 1) the beginning of the Holocene until the Early Neolithic (∼6300/6200 BCE), 2) the end of the Early and the Middle Neolithic (∼6000–5400 BCE), 3) from the Middle Bronze Age to the Late Roman period (∼1800 BCE – 500 CE), and 4) during the Byzantine and Ottoman eras (∼500–1800 CE), all separated by phases of floodplain incision. Furthermore, the effects of several Holocene Rapid Climatic Changes (RCC) are traced and discussed together with potential human responses; we also provide the first alluvial sequence recording the ∼6200 BCE (8.2 kyr BP) event in the Balkans. While the climate and the local geomorphological setting are considered the primary drivers behind instability and erosion during the Early and Middle Holocene, a landscape change starting in the Middle Bronze Age (after ∼1800 BCE) followed by a re-organisation of the rural economy in the Roman period suggests the increasing involvement of anthropogenic forcing which, by the Ottoman period, evolved into a dynamic situation between climatic variability and adaptive land management. Finally, we demonstrate how soil erosion in the upper catchment constitutes a serious taphonomic bias when studying the regional archaeological record.
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- 2024
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- View/download PDF
45. Brain ageing in schizophrenia: evidence from 26 international cohorts via the ENIGMA Schizophrenia consortium.
- Author
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Constantinides, Constantinos, Han, Laura KM, Alloza, Clara, Antonucci, Linda Antonella, Arango, Celso, Ayesa-Arriola, Rosa, Banaj, Nerisa, Bertolino, Alessandro, Borgwardt, Stefan, Bruggemann, Jason, Bustillo, Juan, Bykhovski, Oleg, Calhoun, Vince, Carr, Vaughan, Catts, Stanley, Chung, Young-Chul, Crespo-Facorro, Benedicto, Díaz-Caneja, Covadonga M, Donohoe, Gary, Plessis, Stefan Du, Edmond, Jesse, Ehrlich, Stefan, Emsley, Robin, Eyler, Lisa T, Fuentes-Claramonte, Paola, Georgiadis, Foivos, Green, Melissa, Guerrero-Pedraza, Amalia, Ha, Minji, Hahn, Tim, Henskens, Frans A, Holleran, Laurena, Homan, Stephanie, Homan, Philipp, Jahanshad, Neda, Janssen, Joost, Ji, Ellen, Kaiser, Stefan, Kaleda, Vasily, Kim, Minah, Kim, Woo-Sung, Kirschner, Matthias, Kochunov, Peter, Kwak, Yoo Bin, Kwon, Jun Soo, Lebedeva, Irina, Liu, Jingyu, Mitchie, Patricia, Michielse, Stijn, Mothersill, David, Mowry, Bryan, de la Foz, Víctor Ortiz-García, Pantelis, Christos, Pergola, Giulio, Piras, Fabrizio, Pomarol-Clotet, Edith, Preda, Adrian, Quidé, Yann, Rasser, Paul E, Rootes-Murdy, Kelly, Salvador, Raymond, Sangiuliano, Marina, Sarró, Salvador, Schall, Ulrich, Schmidt, André, Scott, Rodney J, Selvaggi, Pierluigi, Sim, Kang, Skoch, Antonin, Spalletta, Gianfranco, Spaniel, Filip, Thomopoulos, Sophia I, Tomecek, David, Tomyshev, Alexander S, Tordesillas-Gutiérrez, Diana, van Amelsvoort, Therese, Vázquez-Bourgon, Javier, Vecchio, Daniela, Voineskos, Aristotle, Weickert, Cynthia S, Weickert, Thomas, Thompson, Paul M, Schmaal, Lianne, van Erp, Theo GM, Turner, Jessica, Cole, James H, ENIGMA Schizophrenia Consortium, Dima, Danai, and Walton, Esther
- Subjects
ENIGMA Schizophrenia Consortium ,Brain ,Humans ,Magnetic Resonance Imaging ,Prospective Studies ,Schizophrenia ,Aging ,Adolescent ,Adult ,Aged ,Middle Aged ,Female ,Male ,Young Adult ,Mental Health ,Serious Mental Illness ,Brain Disorders ,Neurosciences ,Biomedical Imaging ,Clinical Research ,Behavioral and Social Science ,Neurological ,Mental health ,Good Health and Well Being ,Biological Sciences ,Medical and Health Sciences ,Psychology and Cognitive Sciences ,Psychiatry - Abstract
Schizophrenia (SZ) is associated with an increased risk of life-long cognitive impairments, age-related chronic disease, and premature mortality. We investigated evidence for advanced brain ageing in adult SZ patients, and whether this was associated with clinical characteristics in a prospective meta-analytic study conducted by the ENIGMA Schizophrenia Working Group. The study included data from 26 cohorts worldwide, with a total of 2803 SZ patients (mean age 34.2 years; range 18-72 years; 67% male) and 2598 healthy controls (mean age 33.8 years, range 18-73 years, 55% male). Brain-predicted age was individually estimated using a model trained on independent data based on 68 measures of cortical thickness and surface area, 7 subcortical volumes, lateral ventricular volumes and total intracranial volume, all derived from T1-weighted brain magnetic resonance imaging (MRI) scans. Deviations from a healthy brain ageing trajectory were assessed by the difference between brain-predicted age and chronological age (brain-predicted age difference [brain-PAD]). On average, SZ patients showed a higher brain-PAD of +3.55 years (95% CI: 2.91, 4.19; I2 = 57.53%) compared to controls, after adjusting for age, sex and site (Cohen's d = 0.48). Among SZ patients, brain-PAD was not associated with specific clinical characteristics (age of onset, duration of illness, symptom severity, or antipsychotic use and dose). This large-scale collaborative study suggests advanced structural brain ageing in SZ. Longitudinal studies of SZ and a range of mental and somatic health outcomes will help to further evaluate the clinical implications of increased brain-PAD and its ability to be influenced by interventions.
- Published
- 2023
46. Adaptive Mask-based Pyramid Network for Realistic Bokeh Rendering
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Georgiadis, Konstantinos, Saà-Garriga, Albert, Yucel, Mehmet Kerim, Drosou, Anastasios, and Manganelli, Bruno
- Subjects
Computer Science - Computer Vision and Pattern Recognition - Abstract
Bokeh effect highlights an object (or any part of the image) while blurring the rest of the image, and creates a visually pleasant artistic effect. Due to the sensor-based limitations on mobile devices, machine learning (ML) based bokeh rendering has gained attention as a reliable alternative. In this paper, we focus on several improvements in ML-based bokeh rendering; i) on-device performance with high-resolution images, ii) ability to guide bokeh generation with user-editable masks and iii) ability to produce varying blur strength. To this end, we propose Adaptive Mask-based Pyramid Network (AMPN), which is formed of a Mask-Guided Bokeh Generator (MGBG) block and a Laplacian Pyramid Refinement (LPR) block. MGBG consists of two lightweight networks stacked to each other to generate the bokeh effect, and LPR refines and upsamples the output of MGBG to produce the high-resolution bokeh image. We achieve i) via our lightweight, mobile-friendly design choices, ii) via the stacked-network design of MGBG and the weakly-supervised mask prediction scheme and iii) via manually or automatically editing the intensity values of the mask that guide the bokeh generation. In addition to these features, our results show that AMPN produces competitive or better results compared to existing methods on the EBB! dataset, while being faster and smaller than the alternatives., Comment: ECCV 2022 Advances in Image Manipulation Workshop. See the workshop website for posters and recordings
- Published
- 2022
47. Learning from Adolescents and Caregivers to Enhance Acceptability and Engagement Within Virtual Dialectical Behavior Therapy for Adolescents Skills Groups: A Qualitative Study
- Author
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Conroy, Kristina, Kehrer, Sabrina M., Georgiadis, Christopher, Hare, Megan, Ringle, Vanesa Mora, and Shaw, Ashley M.
- Published
- 2024
- Full Text
- View/download PDF
48. Antibodies against oxidized LDL and atherosclerosis in rheumatoid arthritis patients treated with biological agents: a prospective controlled study
- Author
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Papamichail, G. V., Georgiadis, A. N., Tellis, C. C., Rapti, I., Markatseli, T. E., Xydis, V. G., Tselepis, A. D., Drosos, A. A., and Voulgari, P. V.
- Published
- 2024
- Full Text
- View/download PDF
49. Adjunct fixation in upper extremity long bone fracture plating
- Author
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Georgiadis, Gregory M., Khan, Omar, and Redfern, Roberta E.
- Published
- 2023
- Full Text
- View/download PDF
50. School and learning contexts during the COVID-19 pandemic: Implications for child and youth mental health
- Author
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Tsujimoto, Kimberley C., Cost, Katherine Tombeau, LaForge-MacKenzie, Kaitlyn, Anagnostou, Evdokia, Birken, Catherine S., Charach, Alice, Monga, Suneeta, Kelly, Elizabeth, Nicolson, Rob, Georgiadis, Stelios, Lee, Nicole, Osokin, Konstantin, Arnold, Paul, Schachar, Russell, Burton, Christie, Crosbie, Jennifer, and Korczak, Daphne J.
- Published
- 2023
- Full Text
- View/download PDF
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