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9. Surgical and Perioperative Considerations for the Treatment of Cataract in Eyes with Glaucoma: A Literature Review

Author

Tsakiris, Kleonikos, Kontadakis, George, Georgoudis, Panagiotis, Gatzioufas, Zisis, and Vergados, Athanasios

Subjects
genetic structures, Article Subject, sense organs, eye diseases
Abstract

Cataract surgery in the presence of glaucoma poses certain challenges that need to be addressed to offer the maximum benefit without complications. In this paper, we are reviewing the preoperative assessment, surgical options, the planning, and postoperative care. Cataract surgery can help reduce the intraocular pressure alone or combined with MIGS. When performed in patients with glaucoma, it can transiently increase the intraocular pressure and later on decrease the IOP to levels lower than the postoperative. The preoperative IOP and biometric characteristics are the main predictors of the postoperative course of IOP. The combination of cataract surgery with trabeculectomy remains controversial, in terms of best timing of each operation.

Published
2021
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11. Dexamethasone intravitreal implant (OZURDEX®) for macular edema secondary to noninfectious uveitis: a review of the literature

Author

Massa, Horace, Georgoudis, Panagiotis, and Panos, Georgios D

Subjects
Uveitis, Macular edema, Ozurdex, Ocular inflammation, Dexamethasone intravitreal implant, Steroid, ddc:616.8
Abstract

Macular edema (ME) is the leading cause of visual loss in uveitis and may persist long after ocular inflammation has been resolved. Local steroids are the first line treatment for uveitis and uveitic ME. Dexamethasone intravitreal implant (OZURDEX((R)); Allergan, Inc., CA, USA) has been used to treat diabetic ME and ME secondary to retinal vein occlusion. Recent studies have also demonstrated that Ozurdex may be effective treatment for patients with persistent uveitic ME. In this review, we present the results of the real word studies concerning the efficacy and safety of Ozurdex for the treatment of uveitic ME.

Published
2019

15. [Untitled]

Author

Georgoudis, Panagiotis E.

Subjects
Χαμιλτονιανη του Bohr, Πρότυπο Αλληλεπιδρώντων Μποζονίων, Παράγοντας συμμορφοποίησης, conformal factor, Interacting Boson Model, Πυρηνική Δομή, Συλλογικά Πρότυπα, Deformation-Dependent Mass, Nuclear Structure, Collective models, Μάζα εξαρτημένη από τη παραμόρφωση, γ-unstable and axially symmetric nuclei, Υπερσυμμετρική κβαντομηχανική, Supersymmetric Quantum Mechanics, Ασταθείς ως προς γ και αξονικά συμμετρικοί πυρήνες, Bohr Hamiltonian
Abstract

138 σ., Σε αυτή τη διδακτορική διατριβή η Χαμιλτονιανή του Bohr τροποποιείται αφήνοντας τη παράμετρο μάζας να εξαρτάται από τη θέση (τετραπολική παραμόρφωση), ακολουθώντας τη μέθοδο των Quesne και Tkachuk. Η ακριβής επιλυσιμότητα της προκύπτουσας Χαμιλτονιανής επιτυγχάνεται με μεθόδους υπερσυμμετρικής κβανοτμηχανικής. Αποδεικνύεται ότι για μια ειδική επιλογή των παραμέτρων που εισάγουν οι Quesne και Tkachuk η εξάρτηση της μάζας από τη θέση ισοδυναμεί με ένα παράγοντα συμμορφοποίησης (conformal factor). Με αυτό το τρόπο προτείνεται ένα γεωμετρικό πλαίσιο για την ανάλυση της σχέσης της Χαμιλτονιανής Bohr με το πρότυπο των αλληλεπιδρώντων μποζονίων (Interacting Boson Model) της πυρηνικης δομής., In this doctoral dissertation the Bohr Hamiltonian is modified by letting the mass parameter to depend on the position (quadrupole deformation), following the method of Quesne and Tkachuk. The exact solvability of the deformation-dependent mass Bohr Hamiltonian is achieved by supersymmetric quantum mechanics. It is proved that for a special choice of the parameters of Quesne and Tkachuk the dependence of the mass on the position is equivalent to a conformal factor. In this way a geometrical framework is proposed for the analysis of the relation of the Bohr Hamiltonian to the Interacting Boson Model of nuclear structure.

Published
2015
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16. Συλλογικά πυρηνικά πρότυπα με μάζα εξαρτημένη από τη παραμόρφωση επιλύσιμα με μεθόδους υπερσυμμερικής κβαντομηχανικής

Author

Georgoudis, Panagiotis E., Κουτσούμπας, Γεώργιος, Μπονάτσος, Διονύσης, Παπαδόπουλος, Κωνσταντίνος, Κόκκορης, Μιχάλης, Λαλαζήσης, Γεώργιος, Μαυρομμάτη, Ειρήνη, Φλωράτος, Εμμανουήλ, and Εθνικό Μετσόβιο Πολυτεχνείο. Σχολή Εφαρμοσμένων Μαθηματικών & Φυσικών Επιστημών. Τομέας Φυσικής.

Subjects
Χαμιλτονιανη του Bohr, Πρότυπο Αλληλεπιδρώντων Μποζονίων, Παράγοντας συμμορφοποίησης, conformal factor, Interacting Boson Model, Πυρηνική Δομή, Συλλογικά Πρότυπα, Deformation-Dependent Mass, Nuclear Structure, Collective models, Μάζα εξαρτημένη από τη παραμόρφωση, γ-unstable and axially symmetric nuclei, Υπερσυμμετρική κβαντομηχανική, Supersymmetric Quantum Mechanics, Ασταθείς ως προς γ και αξονικά συμμετρικοί πυρήνες, Bohr Hamiltonian
Abstract

138 σ., Σε αυτή τη διδακτορική διατριβή η Χαμιλτονιανή του Bohr τροποποιείται αφήνοντας τη παράμετρο μάζας να εξαρτάται από τη θέση (τετραπολική παραμόρφωση), ακολουθώντας τη μέθοδο των Quesne και Tkachuk. Η ακριβής επιλυσιμότητα της προκύπτουσας Χαμιλτονιανής επιτυγχάνεται με μεθόδους υπερσυμμετρικής κβανοτμηχανικής. Αποδεικνύεται ότι για μια ειδική επιλογή των παραμέτρων που εισάγουν οι Quesne και Tkachuk η εξάρτηση της μάζας από τη θέση ισοδυναμεί με ένα παράγοντα συμμορφοποίησης (conformal factor). Με αυτό το τρόπο προτείνεται ένα γεωμετρικό πλαίσιο για την ανάλυση της σχέσης της Χαμιλτονιανής Bohr με το πρότυπο των αλληλεπιδρώντων μποζονίων (Interacting Boson Model) της πυρηνικης δομής., In this doctoral dissertation the Bohr Hamiltonian is modified by letting the mass parameter to depend on the position (quadrupole deformation), following the method of Quesne and Tkachuk. The exact solvability of the deformation-dependent mass Bohr Hamiltonian is achieved by supersymmetric quantum mechanics. It is proved that for a special choice of the parameters of Quesne and Tkachuk the dependence of the mass on the position is equivalent to a conformal factor. In this way a geometrical framework is proposed for the analysis of the relation of the Bohr Hamiltonian to the Interacting Boson Model of nuclear structure., Παναγιώτης Ε. Γεωργουδής

Published
2014
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18. A pharmacological modification of pain and epithelial healing in contemporary transepithelial all-surface laser ablation (ASLA)

Author

Aslanides,Ioannis, Selimis,Vasileios, Bessis,Nikolaos, Georgoudis,Panagiotis, Aslanides,Ioannis, Selimis,Vasileios, Bessis,Nikolaos, and Georgoudis,Panagiotis

Abstract

Ioannis M Aslanides, Vasilis D Selimis, Nikolaos V Bessis, Panagiotis N Georgoudis Emmetropia Mediterranean Eye Institute, Heraklion, Crete, Greece Purpose: We report our experience with the use of the matrix regenerating agent (RGTA) Cacicol® after reverse transepithelial all-surface laser ablation (ASLA)-SCHWIND to assess the safety, efficacy, pain, and epithelial healing.Methods: Forty eyes of 20 myopic patients were prospectively recruited to a randomized fellow eye study. Patients underwent transepithelial ASLA in both eyes, with one of the eyes randomly assigned to the use of the RGTA Cacicol. Postoperative pain and vision were subjectively assessed with the use of a questionnaire on the operative day, at 24 hours, 48 hours and 72 hours. Epithelial defect area size was measured at 24 hours, 48 hours, and 72 hours. Uncorrected distance visual acuity (UDVA) and corrected distance visual acuity (CDVA) were assessed at 1 month.Results: Mean UDVA at 1 month was LogMAR 0.028. The epithelial defect area was 10.91 mm2 and 13.28 mm2 at 24 hours and 1.39 mm2 and 1.24 mm2 at 48 hours for treated and nontreated eyes, respectively. Overall, 50% and 65% of treated and nontreated eyes healed by 48 hours. There was no statistically significant difference in the subjective vision between the groups, although vision of patients in the RGTA group was reported to be better. Pain scores were better at 24 hours and 48 hours in the RGTA group but with no statistically significant difference.Conclusion: The use of RGTA Cacicol shows faster epithelial recovery after transepithelial ASLA for myopia. Subjectively reported scores of pain and subjective vision were better in the RGTA group, although the difference was not statistically significant. There seems to be a consensual acceleration of epithelial healing even in eyes that did not receive treatment. There were no adverse events and no incidents of inflammation, delayed healing, or haze. Keywords: matrix regenerating agent

Published
2015

19. Εκφυλισμοί και συμμετρίες στην κρίσιμη περιοχή του Interacting Boson Model

Author

Georgoudis, Panagiotis E., Κουτσούμπας, Γεώργιος, Παπαδόπουλος, Κωνσταντίνος, Μπονάτσος, Διονύσιος, and Εθνικό Μετσόβιο Πολυτεχνείο. Σχολή Εφαρμοσμένων Μαθηματικών και Φυσικών Επιστημών. Τομέας Φυσικής

Subjects
Κβαντκές μεταβολές φάσης, Σύνδεση IBM και Bohr, Αριθμητικοί υπολογισμοί στο κρίσιμο σημείο, Πυρηνική δομή, Συμμετρίες κρίσιμου σημείου
Abstract

88 σ., Εθνικό Μετσόβιο Πολυτεχνείο--Μεταπτυχιακή Εργασία. Διεπιστημονικό-Διατμηματικό Πρόγραμμα Μεταπτυχιακών Σπουδών (Δ.Π.Μ.Σ.) "Φυσική και Τεχνολογικές Εφαρμογές", Εκφυλισμοί και συμμετρίες στη κρίσιμη περιοχή του Interacting Boson Model, Παναγιώτης Ε. Γεωργουδής

Published
2011
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22. Single-step transepithelial ASLA (SCHWIND) with mitomycin-C for the correction of high myopia: long term follow-up

Author

Aslanides,Ioannis, Georgoudis,Panagiotis, Selimis,Vasilis, Mukherjee,Achyut, Aslanides,Ioannis, Georgoudis,Panagiotis, Selimis,Vasilis, and Mukherjee,Achyut

Abstract

Ioannis M Aslanides, Panagiotis N Georgoudis, Vasilis D Selimis, Achyut N Mukherjee Emmetropia Mediterranean Eye Institute, Heraklion, Crete, Greece Purpose: We wanted to compare the outcomes of single-step modified transepithelial photorefractive keratectomy (tPRK) termed a SCHWIND all surface laser ablation (ASLA) versus conventional alcohol-assisted photorefractive keratectomy (PRK) and laser-assisted in situ keratomileusis (LASIK) for the correction of higher myopia of 6.00 diopters (D) or more, in an area with high risk of haze due to high intensity of sunlight.Methods: We used a prospective interventional cohort with matched retrospective control groups. Patients with >6 D myopia and <3.5 D of astigmatism were included. All treatments were performed with the SCHWIND Amaris system using aspheric ablation profiles. Mitomycin C was used in all PRK and ASLA cases. Outcomes were postoperative refraction, visual acuity, stability, and complications. The follow-up period was up to 12 months.Results: In total, 101 eyes were included after exclusions. Mean preoperative spherical equivalent refraction was −7.9 D, −8.2 D, and −7.4 D in the ASLA (n=41), PRK (n=29), and LASIK (n=31) groups. Mean postoperative spherical equivalent at 12 months postoperatively was −0.1 (standard deviation [SD]: 0.34), −0.2 (SD: 0.59), and −0.08 (SD: 0.36) in the ASLA, PRK, and LASIK groups, with 91.4%, 85.7%, and 83.9% within 0.5 D of target, respectively. Refractive outcomes and regression at 12 months did not vary among groups (P>0.05). Mean logMAR (logarithm of the minimum angle of resolution) uncorrected distance visual acuity at 12 months was 0.00 (SD: 0.05), 0.06 (SD: 0.1), and 0.05 (SD: 0.09) in the ASLA, PRK, and LASIK groups, with significantly better vision in the tPRK group versus LASIK (P=0.01) and PRK (P=0.01) groups.Conclusion: ASLA (SCHWIND) tPRK with mitomycin

Published
2014

25. Primary Pterygium Excision Surgery: Analysis of Risk Factors and Clinical Outcomes.

Author

Arun K, Grillon F, and Georgoudis P

Abstract

Purpose To evaluate clinical outcomes of primary pterygium excision surgery and analyze risk factors for pterygium recurrence. Setting Eye Treatment Centre, Cornea and External Diseases Service, Whipps Cross Hospital, London, United Kingdom. Methods Retrospective case series of eyes undergoing primary pterygium excision between August 2017 and July 2022. Patients who underwent "pterygium excision" documented in the electronic patient record system were identified. Patients with recurrent pterygium and those lost-to-follow-up were excluded. The duration of follow-up, type of surgery performed (primary conjunctival closure, conjunctival autograft, and amniotic membrane transplantation), recurrences with respect to the type of surgery performed, and postoperative complications were collected and analyzed. Results In total, 83 eyes (from 79 patients) were included. The mean age of our patient cohort was 59.3 ± 5.9 years. The most common ethnic distribution was Black Caribbean (15.7%). Conjunctival autograft was performed in 76 eyes (91.6%), primary conjunctival closure was performed in five eyes (6%) and amniotic membrane transplantation was performed in two eyes (2.4%). The recurrence rate with conjunctival autograft was 1.3% with a median time to recurrence of 2.98 months. Recurrence was significantly more common in patients below the age of 40 years (p=0.03). Recurrence was not significantly associated with gender (p=0.23), ethnicity (p=0.17), or grade of surgeon (p=0.38).  Conclusion Our findings demonstrate the effectiveness of conjunctival autograft with fibrin glue fixation for the surgical management of primary pterygium. Recurrence was found to be significantly more common in patients under the age of 40 years old. However, recurrence was not associated with ethnicity, gender, or surgeon grade., Competing Interests: The authors have declared that no competing interests exist., (Copyright © 2024, Arun et al.)

Published
2024
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26. Dexamethasone intravitreal implant (OZURDEX ® ) for macular edema secondary to noninfectious uveitis: a review of the literature.

Author

Massa H, Georgoudis P, and Panos GD

Subjects
Cataract chemically induced, Cataract epidemiology, Clinical Trials as Topic, Dexamethasone adverse effects, Disease Progression, Drug Implants adverse effects, Glucocorticoids adverse effects, Humans, Intraocular Pressure drug effects, Intravitreal Injections adverse effects, Macular Edema immunology, Treatment Outcome, Uveitis complications, Uveitis diagnosis, Uveitis immunology, Dexamethasone administration & dosage, Drug Implants administration & dosage, Glucocorticoids administration & dosage, Macular Edema drug therapy, Uveitis drug therapy
Abstract

Macular edema (ME) is the leading cause of visual loss in uveitis and may persist long after ocular inflammation has been resolved. Local steroids are the first line treatment for uveitis and uveitic ME. Dexamethasone intravitreal implant (OZURDEX ® ; Allergan, Inc., CA, USA) has been used to treat diabetic ME and ME secondary to retinal vein occlusion. Recent studies have also demonstrated that Ozurdex may be effective treatment for patients with persistent uveitic ME. In this review, we present the results of the real word studies concerning the efficacy and safety of Ozurdex for the treatment of uveitic ME.

Published
2019
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