1. Immunogenicity of, and immunologic memory to, a reduced primary schedule of meningococcal C-tetanus toxoid conjugate vaccine in infants in the United kingdom
- Author
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Keith Cartwright, Rukhsana Rahim, Elizabeth L. Miller, Geraldine Allan, Jo Southern, Christine Riley, Ray Borrow, Gouri Lal, Nick Andrews, Adam Finn, David Goldblatt, and Lindsey Ashton
- Subjects
Male ,Blood Bactericidal Activity ,Immunology ,Antibody Affinity ,Immunization, Secondary ,Meningococcal Vaccines ,Meningococcal vaccine ,In Vitro Techniques ,Neisseria meningitidis ,Meningococcal disease ,Microbiology ,Conjugate vaccine ,medicine ,Tetanus Toxoid ,Animals ,Humans ,Avidity ,Immunization Schedule ,Tetanus ,business.industry ,Immunogenicity ,Diphtheria ,Toxoid ,Infant ,medicine.disease ,Antibodies, Bacterial ,United Kingdom ,Infectious Diseases ,Immunoglobulin G ,Microbial Immunity and Vaccines ,Parasitology ,Female ,Rabbits ,business ,Immunologic Memory - Abstract
It has been previously shown that one of the three meningococcal C conjugate (MCC) vaccines introduced in the United Kingdom proved highly immunogenic after the first dose of a three-dose schedule, with evidence of immune memory after dose 3. Thus, in infants a one- or two-dose schedule of this MCC vaccine, conjugated to tetanus toxoid (TT), may suffice. Healthy infants ( n = 586) were randomized to receive either one (group 1), two (group 2), or three (group 3) doses of MCC-TT vaccine with a 10-μg polysaccharide booster given at 13 to 14 months of age. Serum bactericidal antibody (SBA) levels were measured by utilizing rabbit complement (rSBA), meningococcal C-specific immunoglobulin G (IgG), and avidity indices (AIs). For groups 1, 2, and 3, the percentages of infants with an rSBA level of ≥8 against strain C11 were 98.4, 100, and 99.4%, respectively. Infants in group 1 with prevaccination rSBA titers of ≥8 had post-primary MCC rSBA geometric mean titers (GMTs) significantly lower than those infants with prevaccination rSBA titers of
- Published
- 2003