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3 results on '"Gerard J.J. van Doornum"'

1. Response to Imported Case of Marburg Hemorrhagic Fever, the Netherlands

Author

Aura Timen, Marion P.G. Koopmans, Ann C.T.M. Vossen, Gerard J.J. van Doornum, Stephan Günther, Franchette van den Berkmortel, Kees M. Verduin, Sabine Dittrich, Petra Emmerich, Albert D.M.E. Osterhaus, Jaap T. van Dissel, and Roel A. Coutinho

Subjects
Marburg virus diseases, hemorrhagic fever, exposure, contacts, temperature monitoring, filovirus, Medicine, Infectious and parasitic diseases, RC109-216
Abstract

On July 10, 2008, Marburg hemorrhagic fever was confirmed in a Dutch patient who had vacationed recently in Uganda. Exposure most likely occurred in the Python Cave (Maramagambo Forest), which harbors bat species that elsewhere in Africa have been found positive for Marburg virus. A multidisciplinary response team was convened to perform a structured risk assessment, perform risk classification of contacts, issue guidelines for follow-up, provide information, and monitor the crisis response. In total, 130 contacts were identified (66 classified as high risk and 64 as low risk) and monitored for 21 days after their last possible exposure. The case raised questions specific to international travel, postexposure prophylaxis for Marburg virus, and laboratory testing of contacts with fever. We present lessons learned and results of the follow-up serosurvey of contacts and focus on factors that prevented overreaction during an event with a high public health impact.

Published
2009
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2. Seroepidemiology of human papillomavirus type 73: A sexually transmitted low-risk virus

Author

Joakim Dillner, Keng-Ling Wallin, Ingegerd Kallings, Gerard J.J. van Doornum, John T. Schiller, Fredrik Wiklund, Göran Hallmans, and Agneta Andersson-Ellström

Subjects
Cervical cancer, Cancer Research, education.field_of_study, business.industry, Population, Prevalence, virus diseases, medicine.disease, Virology, female genital diseases and pregnancy complications, Serology, medicine.anatomical_structure, Oncology, Immunology, medicine, Seroprevalence, Viral disease, Risk factor, education, business, Cervix
Abstract

Human papillomavirus type 73 (HPV 73) has been detected in some invasive cervical cancers and has been cloned from a squamous-cell carcinoma of the esophagus, but the epidemiology of this infection and its associated risk of cancer is unknown. We investigated the seroepidemiology of this virus using virus-like particles. The IgG response to HPV 73 appeared to be HPV type-specific, since a comparison of HPV 73 antibody levels before and after infection with HPV 6, 11, 16, 18 or 33 found no evidence of cross-induction of HPV 73 antibodies and since there was little correlation between the antibody levels to HPV 73 and the other 5 investigated HPV types. In both a cross-sectional serosurvey that included 274 women and a 7-year follow-up study that enrolled 98 women, HPV 73 seropositivity was found to be strongly dependent on the number of lifetime sexual partners [OR for > 4 vs. 0 to 1 partners: 6.0 (95%CI: 1.4–53.6) and 7.9 (95% CI: 2.8–28.3), respectively]. Finally, the risk for HPV 73 seropositive women to develop CIN was investigated in a prospective study nested in a cohort of 15,234 Swedish women. The population-based HPV 73 seroprevalence in Sweden was 14%. No excess risk for CIN was found (OR: 0.77). We conclude that HPV 73 is a mainly sexually transmitted, probably mostly transient, infection that does not confer any measurably increased risk for CIN development. Int. J. Cancer 85:353–357, 2000. ©2000 Wiley-Liss, Inc.

Published
2000
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3. Human metapneumovirus infection in hospital referred South African children (The study was approved by the University of Stellenbosch medical ethical committee and informed consent was obtained from all children's parents or legal guardians for participation in our study and for HIV testing specifically, after pre-test HIV counseling.) Frank F.A. Ijpma and Dennis Beekhuis contributed equally to this study.) This study was performed in part at the Department of Paediatrics and Child Health, Tygerberg Children's Hospital, Parow, South Africa and at the Department of Virology, Erasmus University Hospital, Rotterdam, The Netherlands.)

Author

Frank F.A. IJpma, Dennis Beekhuis, Mark F. Cotton, Clarissa H. Pieper, Jan L.L. Kimpen, Bernadette G. van den Hoogen, Gerard J.J. van Doornum, and D.M.E. Osterhaus

Published
2004

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