804 results on '"Gerardin P"'
Search Results
2. The hadronic light-by-light contribution to the muon $g{-}2$ using staggered fermions at the physical point
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Zimmermann, Christian and Gérardin, Antoine
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High Energy Physics - Lattice - Abstract
Hadronic contributions dominate the uncertainty of the Standard Model prediction for the anomalous magnetic moment of the muon. In this work, we present results on the hadronic light-by-light contribution obtained from the evaluation of the hadronic four-point function of electromagnetic currents using the position-space formalism developed by the Mainz group. The simulations are performed with staggered fermions directly at the physical point. Several physical volumes are used to estimate finite volume effects. This direct lattice study is supplemented by considering the contribution of the light pseudoscalar pole in both finite and infinite volumes, where we reuse the pseudoscalar transition form factors that have been evaluated in previous simulations on the same ensembles., Comment: 7 pages, 6 figures, LATTICE2024 conference proceedings, submitted to PoS
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- 2024
3. Lattice QCD calculation of the $\eta$ and $\eta^{\prime}$ meson masses at the physical point using rooted staggered fermions
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Verplanke, Willem E. A., Fodor, Zoltan, Gerardin, Antoine, Guenther, Jana N., Lellouch, Laurent, Szabo, Kalman K., Toth, Balint C., and Varnhorst, Lukas
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High Energy Physics - Lattice ,High Energy Physics - Phenomenology - Abstract
We present a lattice calculation of the $\eta$ and $\eta^{\prime}$ meson masses at the physical point and in the continuum limit, based on $N_f = 2+1+1$ flavors of rooted staggered quarks. Our analysis includes gauge ensembles at the physical pion and kaon masses spread over six lattice spacings in the range [0.064-0.1315]~fm. Our main results read $m_{\eta} = 543.5(5.6)~$MeV and $m_{\eta^{\prime}} = 986(38)~$MeV, consistent with the experimental values. This is an important numerical test that supports the validity of the fourth root procedure used in the staggered quark formalism. This calculation was the first step towards extracting the pseudoscalar transition form factors of the $\eta$ and $\eta^{\prime}$ mesons that play a crucial role in the hadronic light-by-light contribution to the muon $g-2$., Comment: 19 pages, 12 figures
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- 2024
4. High precision calculation of the hadronic vacuum polarisation contribution to the muon anomaly
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Boccaletti, A., Borsanyi, Sz., Davier, M., Fodor, Z., Frech, F., Gerardin, A., Giusti, D., Kotov, A. Yu., Lellouch, L., Lippert, Th., Lupo, A., Malaescu, B., Mutzel, S., Portelli, A., Risch, A., Sjo, M., Stokes, F., Szabo, K. K., Toth, B. C., Wang, G., and Zhang, Z.
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High Energy Physics - Lattice ,High Energy Physics - Phenomenology ,High Energy Physics - Theory - Abstract
We present a new lattice QCD calculation of the leading order hadronic vacuum polarization contribution to the muon anomalous magnetic moment $a_\mu$. We reduce uncertainties compared to our earlier computation by $40\%$, arXiv:2002.12347. We perform simulations on finer lattices allowing for an even more accurate continuum extrapolation. We also include a small, long-distance contribution obtained using input from experiments in a low-energy regime where they all agree. Combined with other standard model contributions our result leads to a prediction that differs from the measurement of $a_\mu$ by only 0.9 standard deviations. This provides a remarkable validation of the standard model to 0.37ppm., Comment: 55 pages, 31 figures
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- 2024
5. The PolarKID project: polarization measurements with KIDs for the next generation of CMB telescopes
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Savorgnano, Sofia, Bounmy, Julien, Bourrion, Olivier, Calvo, Martino, Catalano, Andrea, Choulet, Olivier, Garde, Gregory, Gerardin, Anne, Kusulja, Mile, Perez, Juan Francisco Macias, Monfardini, Alessandro, Tourres, Damien, and Vezzu, Francis
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Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
The goal of the PolarKID project is testing a new method for the measurement of polarized sources, in order to identify all the possible instrumental systematic effects that could impact the detection of CMB B-modes of polarization. It employs the KISS (KIDs Interferometer Spectrum Survey) instrument coupled to a sky simulator and to sources such as point-like black bodies (simulating planets), a dipole (extended source) and a polarizer. We use filled-arrays Lumped Element Kinetic Inductance Detectors (LEKIDs) since they have multiple advantages when observing both in a photometry and in a polarimetry configuration, Comment: 8 pages, 1 figure, Proceeding of the SPIE conference Millimeter, Submillimeter, and Far-Infrared Detectors and Instrumentation for Astronomy XII, SPIE Astronomical Telescopes + Instrumentation 2024
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- 2024
6. Aluminum nuclear demagnetization refrigerator for powerful continuous cooling
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Raba, Matthias, Triqueneaux, Sébastien, Butterworth, James, Schmoranzer, David, Barria, Emilio, Debray, Jérôme, Donnier-Valentin, Guillaume, Gandit, Thibaut, Gerardin, Anne, Goupy, Johannes, Tissot, Olivier, Collin, Eddy, and Fefferman, Andrew
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Physics - Instrumentation and Detectors - Abstract
Many laboratories routinely cool samples to 10 mK, but relatively few can cool condensed matter below 1 mK. Easy access to the microkelvin range would propel fields such as quantum sensors and quantum materials. Such temperatures are achieved with adiabatic nuclear demagnetization. Existing nuclear demagnetization refrigerators (NDR) are ``single-shot'', and the recycling time is incompatible with some sub-mK experiments. Furthermore, a high cooling power is required to overcome the excess heat load of order nW on NDR pre-cooled by cryogen-free dilution refrigerators. We report the performance of an aluminum NDR designed for powerful cooling when part of a dual stage continuous NDR (CNDR). Its thermal resistance is minimized to maximize the cycling rate of the CNDR and consequently its cooling power. At the same time, its susceptibility to eddy current heating is minimized. A CNDR based on two of the aluminum NDR presented here would achieve a cooling power of approximately 40 nW at 560 $\mu$K less than six days after cooling from room temperature, with a small offset in electronic temperature that decreases as the time-dependent heat load decays.
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- 2024
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7. Superior performance of nickel doped vanadium pentoxide nanoparticles and their photocatalytic, antibacterial and antioxidant activities
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Remila, A., Shally, V., Parvathiraja, C., Darwin, T., Dharshini, M. Priya, Jayam, T. Gerardin, Wabaidur, Saikh M., and Siddiqui, Masoom Raza
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- 2024
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8. A strategy for B-physics observables in the continuum limit
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Conigli, Alessandro, Frison, Julien, Fritzsch, Patrick, Gérardin, Antoine, Heitger, Jochen, Herdoiza, Gregorio, Kuberski, Simon, Pena, Carlos, Simma, Hubert, and Sommer, Rainer
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High Energy Physics - Lattice ,High Energy Physics - Phenomenology - Abstract
In a somewhat forgotten paper [1] it was shown how to perform interpolations between relativistic and static computations in order to obtain results for heavy-light observables for masses from, say, $m_{\rm charm}$ to $m_{\rm bottom}$. All quantities are first continuum extrapolated and then interpolated in $1/m_h=1/m_{\rm heavy}$. Large volume computations are combined with finite volume ones where a relativistic bottom quark is accessible with small $am_{\rm bottom}$. We discuss how this strategy is extended to semi-leptonic form factors and other quantities of phenomenological interest. The essential point is to form quantities where the limit $m_h\to\infty$ is approached with power corrections O$(1/m_h)$ only. Perturbative corrections $\sim\alpha_s(m_h)^{\gamma+n}$ are cancelled in the construction of the observables. We also point out how such an approach can help to control systematics in semi-leptonic decays with just large volume data. First numerical results with $N_f = 2 + 1$ and lattice spacings down to 0.039 fm are presented in [2]., Comment: Lattice 2023 talk
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- 2023
9. $m_B$ and $f_{B^{(\star)}}$ in $2+1$ flavour QCD from a combination of continuum limit static and relativistic results
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Conigli, Alessandro, Frison, Julien, Fritzsch, Patrick, Gérardin, Antoine, Heitger, Jochen, Herdoiza, Gregorio, Kuberski, Simon, Pena, Carlos, Simma, Hubert, and Sommer, Rainer
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High Energy Physics - Lattice ,High Energy Physics - Phenomenology - Abstract
We present preliminary results for B-physics from a combination of non-perturbative results in the static limit with relativistic computations satisfying $am_{\mathrm{heavy}}\ll 1$. Relativistic measurements are carried out at the physical b-quark mass using the Schr\"{o}dinger Functional in a $0.5 \ \mathrm{fm}$ box. They are connected to large volume observables through step scaling functions that trace the mass dependence between the physical charm region and the static limit, such that B-physics results can be obtained by interpolation; the procedure is designed to exactly cancel the troublesome $\alpha_s(m_{\mathrm{heavy}})^{n+\gamma}$ corrections to large mass scaling. Large volume computations for both static and relativistic quantities use CLS $N_f=2+1$ ensembles at $m_u=m_d=m_s$, and with five values of the lattice spacing down to $0.039$ fm. Our preliminary results for the b-quark mass and leptonic decay constants have competitive uncertainties, which are furthermore dominated by statistics, allowing for substantial future improvement. Here we focus on numerical results, while the underlying strategy is discussed in a companion contribution., Comment: Lattice 2023 talk
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- 2023
10. Investigation of the hadronic light-by-light contribution to the muon $g{-}2$ using staggered fermions
- Author
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Zimmermann, Christian and Gérardin, Antoine
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High Energy Physics - Lattice ,High Energy Physics - Phenomenology - Abstract
Hadronic contributions dominate the uncertainty of the standard model prediction for the anomalous magnetic moment of the muon. In this work, we describe an ongoing lattice calculation of the hadronic light-by-light contribution, performed with staggered fermions. The presence of quarks with different tastes complicates the analysis of the position-space correlation function. We present a suitable adaption of the "Mainz method". As a first numerical test, we reproduce the well-known lepton-loop contribution. Results at a single lattice spacing for the light quark contribution, using two volumes, are then discussed. Our study of the long distance behavior and finite-volume effects is supplemented by considering the contribution of the light pseudoscalar-pole. The corresponding transition form factors have been evaluated in previous simulations on the same ensembles., Comment: 7 pages, 6 figures, LATTICE2023 conference proceedings, submitted to PoS
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- 2023
11. Status update: $\pi^0\to \gamma^\ast \gamma^\ast$ transition form factor on CLS ensembles
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Koponen, Jonna, Gérardin, Antoine, Meyer, Harvey B., Ottnad, Konstantin, and von Hippel, Georg
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High Energy Physics - Lattice - Abstract
In this report we present the status of the Mainz group's lattice QCD calculation of the pion transition form factor, which describes the interaction of an on-shell pion with two off-shell photons. This form factor is the main ingredient in the calculation of the pion-pole contribution to hadronic light-by-light scattering in the muon $g-2$. We use the $N_f = 2 + 1$ CLS gauge ensembles, and we update our previous work by including a physical pion mass ensemble (E250). We compute the transition form factor in a moving frame as well as in the pion rest frame in order to have access to a wider range of photon virtualities. In addition to the quark-line connected correlator we also compute the quark-line disconnected diagrams that contribute to the form factor. At the final stage of the analysis, the result on E250 will be combined with the previous work published in 2019 to extrapolate the form factor to the continuum and to physical quark masses., Comment: Proceedings of the 40th International Symposium on Lattice Field Theory (Lattice 2023), July 31st - August 4th, 2023, Fermilab, Batavia, Illinois, USA
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- 2023
12. Early-onset anorexia nervosa: a scoping review and management guidelines
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Ayrolles, Anaël, Clarke, Julia, Godart, Nathalie, André-Carletti, Céline, Barbe, Clémentine, Bargiacchi, Anne, Blanchet, Corinne, Bergametti, Florence, Bertrand, Valérie, Caldagues, Emmanuelle, Caquard, Marylene, Castellotti, Danielle, Delorme, Richard, Dreno, Laurence, Landou, Dominique Feneon, Gerardin, Priscille, Guessoum, Selim, Gicquel, Ludovic, Léger, Juliane, Legras, Stéphanie, Noel, Lucile, Fjellestad-Paulsen, Anne, Poncet-Kalifa, Hélène, Bat-Pitault, Flora, and Stordeur, Coline
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- 2024
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13. Borderline personality disorder and post-traumatic stress disorder in adolescents: protocol for a comparative study of borderline personality disorder with and without comorbid post-traumatic stress disorder (BORDERSTRESS-ADO)
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Riou, Maëlle, Duclos, Harmony, Leribillard, Méline, Parienti, Jean-Jacques, Segobin, Shailendra, Viard, Armelle, Apter, Gisèle, Gerardin, Priscille, Guillery, Bérengère, and Guénolé, Fabian
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- 2024
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14. Frequency of polymorphisms in the IKZF1 and CDKN2A/2B genes and descriptive analysis in pediatric patients with acute lymphoblastic leukemia: a multicenter hospital-based prevalence study in Rio De Janeiro
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da Rocha Figueiredo, Ariadne, da Conceição Barbosa, Thayana, Emerenciano, Mariana, and Land, Marcelo Gerardin Poirot
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- 2024
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15. Diagnostic performance of an ultra-sensitive RDT and a conventional RDT in malaria mass testing, treatment and tracking interventions in southern Ghana
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Amoah, Linda Eva, Cheng, Ndong Ignatius, Acquah, Festus Kojo, Adu-Amankwah, Susan, Bredu, Dorcas Gyama, Mensah, Benedicta A., Anang, Sherik-fa, Abban, Bernice Cubson, Busayomi, Abena, Kwarpong, Sebastian Shine, Tey, Prosper Kofi, Cudjoe, Elizabeth, Asamoah, Alexander, Holden, Tobias McKenzie, Gerardin, Jaline, Nonvignon, Justice, and Ahorlu, Collins
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- 2024
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16. AI powered quantification of nuclear morphology in cancers enables prediction of genome instability and prognosis
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Abel, John, Jain, Suyog, Rajan, Deepta, Padigela, Harshith, Leidal, Kenneth, Prakash, Aaditya, Conway, Jake, Nercessian, Michael, Kirkup, Christian, Javed, Syed Ashar, Biju, Raymond, Harguindeguy, Natalia, Shenker, Daniel, Indorf, Nicholas, Sanghavi, Darpan, Egger, Robert, Trotter, Benjamin, Gerardin, Ylaine, Brosnan-Cashman, Jacqueline A., Dhoot, Aditya, Montalto, Michael C., Parmar, Chintan, Wapinski, Ilan, Khosla, Archit, Drage, Michael G., Yu, Limin, and Taylor-Weiner, Amaro
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- 2024
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17. “Naloxone? Not for me!” First cross-assessment by patients and healthcare professionals of the risk of opioid overdose
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Aquizerate, Aurélie, Rousselet, Morgane, Cochard, Axel, Guerlais, Marylène, Gerardin, Marie, Lefebvre, Emilie, Duval, Mélanie, Laforgue, Edouard-Jules, and Victorri-Vigneau, Caroline
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- 2024
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18. Early-onset anorexia nervosa: a scoping review and management guidelines
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Anaël Ayrolles, Julia Clarke, Nathalie Godart, Céline André-Carletti, Clémentine Barbe, Anne Bargiacchi, Corinne Blanchet, Florence Bergametti, Valérie Bertrand, Emmanuelle Caldagues, Marylene Caquard, Danielle Castellotti, Richard Delorme, Laurence Dreno, Dominique Feneon Landou, Priscille Gerardin, Selim Guessoum, Ludovic Gicquel, Juliane Léger, Stéphanie Legras, Lucile Noel, Anne Fjellestad-Paulsen, Hélène Poncet-Kalifa, Flora Bat-Pitault, and Coline Stordeur
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Childhood ,Diagnosis ,Management ,Recommendation ,Early-onset anorexia nervosa ,Psychiatry ,RC435-571 - Abstract
Abstract Background Anorexia nervosa (AN) is a serious multifactorial eating disorder characterized by insufficient nutritional intake to maintain a minimum normal weight for one's age and height, a fear of gaining weight and a distorted body image. It affects mainly adolescents, but a decreased age at diagnosis has been reported, leading to the definition of a rare form of AN called early-onset or prepubertal anorexia nervosa (EOAN; ORPHA 525738), with reported epidemiological and clinical specificity. Current knowledge and specific treatments for this particular condition remain scarce. We aim to summarize the literature review and synthesize actual knowledge on EOAN for preliminary guidelines to harmonize the diagnosis, treatment and follow-up. Methods A scoping literature review was performed from 2010-2021 using PubMed, Web of Science, PsycInfo and Cochrane via the following search terms: (anorexia nervosa) AND (early-onset OR premenarchal OR prepubertal OR childhood). International guidelines were screened for additional hits. Data extraction was limited to findings relevant to the key topic questions: epidemiology and clinical specificities section, diagnosis and initial evaluation section, treatment section, and follow-up and prognosis section. Results A total of 1257 titles were retrieved via the initial search strategy. Finally, 42 records were included in the present article (30 articles and 11 international guidelines and 1 literature review). We identified 15 articles relevant for the epidemiology and clinical specificities section, 11 for the diagnosis and initial evaluation section, 3 for the treatment section, and 1 for the follow-up and prognosis section. Despite the growing literature on the epidemiological and clinical features of EOAN, knowledge of specific treatments and prognoses remains scarce in the absence of extensive standardized data collection and few age-specific clinical research protocols. Current international guidelines generally extrapolate strategies proposed for adolescents and young adults to children with a low level of evidence. Conclusions Continuing research efforts in this specific younger population is needed to validate child-specific care strategies, enabling the establishment of age-appropriate recommendations with a higher level of evidence targeting specific determinants and clinical specificities of EOAN.
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- 2024
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19. Borderline personality disorder and post-traumatic stress disorder in adolescents: protocol for a comparative study of borderline personality disorder with and without comorbid post-traumatic stress disorder (BORDERSTRESS-ADO)
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Maëlle Riou, Harmony Duclos, Méline Leribillard, Jean-Jacques Parienti, Shailendra Segobin, Armelle Viard, Gisèle Apter, Priscille Gerardin, Bérengère Guillery, and Fabian Guénolé
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Adolescent ,Female ,Post-traumatic stress disorder ,Neuroanatomy ,Borderline personality disorder ,Comorbidity ,Psychiatry ,RC435-571 - Abstract
Abstract Background Borderline Personality Disorder (BPD) is a prevalent and debilitating psychiatric condition often accompanied by Post-Traumatic Stress Disorder (PTSD), with a substantial prevalence of trauma history among affected individuals. The clinical, cognitive, and cerebral parallels shared with PTSD suggest a trauma-related etiology for BPD. Studies consistently demonstrate a reduction in hippocampal volume in individuals with BPD, echoing findings in PTSD. However, the interpretation of this shared neurobiological profile remains contentious, with ongoing debates regarding the independence of these pathologies or the potential exacerbation of diminished hippocampal volume in BPD due to concurrent PTSD. Differential impacts on hippocampal subfields across both disorders may further complicate interpretation, suggesting the volume of hippocampal subfields as a potential discriminant biomarker. This study aims to characterize the multidimensional specific and shared profiles of BPD and PTSD-related alterations, with a particular emphasis on hippocampal subfields during adolescence, a crucial period in BPD development. Methods This study focuses on female adolescents, who are more prevalent in the BPD population. Participants are categorized into three groups: BPD, BPD with comorbid PTSD, and a control group of matched healthy individuals. Data collection encompasses clinical, cognitive, and neuroimaging domains commonly affected in both disorders, utilizing various imaging markers (including gray matter macrostructure, white matter microstructural integrity, and regional functional connectivity). Discussion This study examines adolescent BPD with and without comorbid PTSD on clinical, neuroimaging, and cognitive levels. It is the first to use a comprehensive multi-modal approach within the same sample. Additionally, it uniquely explores hippocampal subfield volume differences in adolescents. Analysis of the relationship between the investigated domains and the effects of PTSD comorbidity will elucidate specific and shared alteration profiles in both disorders. Trial registration IDRCB number 2019-A00366-51 / clinicaltrials.gov ID: NCT0485274. Registered on 21/04/2021.
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- 2024
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20. Gallbladder Burkitt’s Lymphoma: A Literature Review Including a Case Report in a Child Living with HIV
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Nathalia Lopez Duarte, Ana Paula Silva Bueno, Bárbara Sarni Sanches, Gabriella Alves Ramos, Layanara Albino Batista, Thalita Fernandes de Abreu, Marcelo Gerardin Poirot Land, and Cristiane Bedran Milito
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Burkitt’s lymphoma ,gallbladder ,malignant lymphoma ,gallbladder cancer ,HIV ,pediatric ,Other systems of medicine ,RZ201-999 - Abstract
Malignant lymphoma is an unusual form of gallbladder neoplasm. Almost all these tumors are diffuse large B-cell lymphomas or mucosa-associated lymphoid tissue-type lymphomas. Herein, we present a literature review of gallbladder Burkitt’s lymphoma (BL) cases that includes also an unpublished case in an HIV-infected child, observed by our center. The patient (a five-year-old black female child) attended the Federal Hospital of Lagoa, Rio de Janeiro, Brazil, underwent cholecystectomy, and the postoperative pathological analysis of the gallbladder revealed a diagnosis of BL (EBV-positive). Also, HIV serology was performed and returned positive. She was transferred to the Martagão Gesteira Institute of Pediatrics and Childcare for oncological treatment, dying from sepsis and disease progression about 18 months later. The patient did not undergo ART/cART. Previous cases of gallbladder BL were herein described and analyzed to characterize the clinicopathological features and possible similarities. BL can occur in the gallbladder both in the context of HIV infection and in the pediatric population. A biopsy is mandatory in cases with suggestive findings of lymphoma, and an early diagnosis can change the course of the disease. Furthermore, the case highlights the importance of an early initiation of ART/cART in people living with HIV (PLWH), especially in children.
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- 2024
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21. Development of an integrated analytical platform for clay mineral separation, characterization and K–Ar dating
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M. Gerardin, G. Milesi, J. Mercadier, M. Cathelineau, and D. Bartier
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Geophysics. Cosmic physics ,QC801-809 - Abstract
Isotopic dating is a valuable method to constrain the timing of lithospheric processes: geodynamic episodes, ore deposition and geothermal regimes. The K–Ar dating technique has the main advantage of being applied to ubiquitous K-bearing minerals that crystallize at various temperatures, from magmatic to low temperatures. Clays are of significant interest among all K-bearing minerals, as they crystallize during various hydrothermodynamic processes. Nonetheless, the dating of illites by the K–Ar method is not straightforward. K–Ar dates on illite usually rely on a mixed isotopic signal referring to various illitic populations that might have experienced isotopic resetting or recrystallization processes. Therefore, reliable K–Ar dates on illite depend on (1) the grain size separation of large numbers of clay fractions; (2) the study of the morphology, mineralogy and crystallography; (3) the determination of precise K–Ar dates on each clay size fraction; and (4) the meaningful interpretation of ages using either end-member ages or the illite age analysis (IAA) method. This paper describes the instrumentation and methods recently developed at the GeoRessources laboratory of the University of Lorraine to obtain valuable ages on illite mixtures.
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- 2024
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22. Frequency of polymorphisms in the IKZF1 and CDKN2A/2B genes and descriptive analysis in pediatric patients with acute lymphoblastic leukemia: a multicenter hospital-based prevalence study in Rio De Janeiro
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Ariadne da Rocha Figueiredo, Thayana da Conceição Barbosa, Mariana Emerenciano, and Marcelo Gerardin Poirot Land
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SNP ,Polymorphisms ,ALL ,B-ALL ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Background Acute lymphoblastic leukemia (ALL) is the most common childhood cancer, and B-cell ALL (B-ALL) is the most common subtype. The understanding of ALL has advanced significantly in recent years due to genomic sequencing, which has made it possible to identify genetic variants and detect the association between “single nucleotide polymorphisms” (SNP) and certain diseases. Methods We evaluated 126 patients diagnosed with B-ALL in hospitals in Rio de Janeiro. We described the frequency of polymorphisms in the IKZF1, CDKN2A/2B genes, the contribution of these genetic variants in pediatric ALL, and compared them with the general population of Rio de Janeiro. Results We demonstrated that the SNPs rs3731217, rs4132601, and rs11978267 were more frequent in patients with B-ALL. Conclusions These findings contribute to a more complete understanding of B-ALL. They can guide future studies, bringing new perspectives on personalized therapies with reduced side effects and optimization efficacy of B-ALL treatment in children.
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- 2024
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23. NSF RESUME HPC Workshop: High-Performance Computing and Large-Scale Data Management in Service of Epidemiological Modeling
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Stevens, Abby, Ozik, Jonathan, Chard, Kyle, Gerardin, Jaline, and Wozniak, Justin M.
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Computer Science - Computers and Society - Abstract
The NSF-funded Robust Epidemic Surveillance and Modeling (RESUME) project successfully convened a workshop entitled "High-performance computing and large-scale data management in service of epidemiological modeling" at the University of Chicago on May 1-2, 2023. This was part of a series of workshops designed to foster sustainable and interdisciplinary co-design for predictive intelligence and pandemic prevention. The event brought together 31 experts in epidemiological modeling, high-performance computing (HPC), HPC workflows, and large-scale data management to develop a shared vision for capabilities needed for computational epidemiology to better support pandemic prevention. Through the workshop, participants identified key areas in which HPC capabilities could be used to improve epidemiological modeling, particularly in supporting public health decision-making, with an emphasis on HPC workflows, data integration, and HPC access. The workshop explored nascent HPC workflow and large-scale data management approaches currently in use for epidemiological modeling and sought to draw from approaches used in other domains to determine which practices could be best adapted for use in epidemiological modeling. This report documents the key findings and takeaways from the workshop.
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- 2023
24. Hadronic vacuum polarization: comparing lattice QCD and data-driven results in systematically improvable ways
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Davier, Michel, Fodor, Zoltan, Gerardin, Antoine, Lellouch, Laurent, Malaescu, Bogdan, Stokes, Finn M., Szabo, Kalman K., Toth, Balint C., Varnhorst, Lukas, and Zhang, Zhiqing
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High Energy Physics - Phenomenology ,High Energy Physics - Experiment ,High Energy Physics - Lattice - Abstract
The precision with which hadronic vacuum polarization (HVP) is obtained determines how accurately important observables, such as the muon anomalous magnetic moment, a_\mu, or the low-energy running of the electromagnetic coupling, \alpha, are predicted. The two most precise approaches for determining HVP are: dispersive relations combined with e+e- to hadrons cross-section data, and lattice QCD. However, the results obtained in these two approaches display significant tensions, whose origins are not understood. Here we present a framework that sheds light on this issue and, if the two approaches can be reconciled, allows them to be combined. Via this framework, we test the hypothesis that the tensions can be explained by modifying the R-ratio in different intervals of center-of-mass energy sqrt(s). As ingredients, we consider observables that have been precisely determined in both approaches. These are the leading hadronic contributions to a_\mu, to the so-called intermediate window observable and to the running of \alpha between spacelike virtualities 1GeV^2 and 10GeV^2 (for which only a preliminary lattice result exists). Our tests take into account all uncertainties and correlations, as well as uncertainties on uncertainties in the lattice results. Among our findings, the most striking is that results obtained in the two approaches can be made to agree for all three observables by modifying the \rho peak in the experimental spectrum. In particular, we find that this requires a common ~5\% increase in the contributions of the peak to each of the three observables. This finding is robust against the presence or absence of one of the constraining observables. However, such an increase is much larger than the uncertainties on the measured R-ratio. We also discuss a variety of generalizations of the methods used here, as well as the limits in the information that can be extracted..., Comment: 38 pages, 8 figures
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- 2023
25. Bimanual coordinated motor skill learning in patients with a chronic cerebellar stroke
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Gathy, Estelle, Cadiat, Ninon, Gerardin, Eloïse, Lambert, Julien, Herman, Benoît, Leeuwerck, Mie, Bihin, Benoît, and Vandermeeren, Yves
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- 2024
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26. Improved statistical benchmarking of digital pathology models using pairwise frames evaluation
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Gerardin, Ylaine, Shamshoian, John, Shen, Judy, Le, Nhat, Prezioso, Jamie, Abel, John, Finberg, Isaac, Borders, Daniel, Biju, Raymond, Nercessian, Michael, Prasad, Vaed, Lee, Joseph, Wyman, Spencer, Gupta, Sid, Emerson, Abigail, Rahsepar, Bahar, Sanghavi, Darpan, Leung, Ryan, Yu, Limin, Khosla, Archit, and Taylor-Weiner, Amaro
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Computer Science - Computer Vision and Pattern Recognition ,Computer Science - Machine Learning - Abstract
Nested pairwise frames is a method for relative benchmarking of cell or tissue digital pathology models against manual pathologist annotations on a set of sampled patches. At a high level, the method compares agreement between a candidate model and pathologist annotations with agreement among pathologists' annotations. This evaluation framework addresses fundamental issues of data size and annotator variability in using manual pathologist annotations as a source of ground truth for model validation. We implemented nested pairwise frames evaluation for tissue classification, cell classification, and cell count prediction tasks and show results for cell and tissue models deployed on an H&E-stained melanoma dataset., Comment: 10 pages, 7 figures
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- 2023
27. Impact of translation on biomedical information extraction from real-life clinical notes
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Gérardin, Christel, Xiong, Yuhan, Wajsbürt, Perceval, Carrat, Fabrice, and Tannier, Xavier
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Computer Science - Computation and Language - Abstract
The objective of our study is to determine whether using English tools to extract and normalize French medical concepts on translations provides comparable performance to French models trained on a set of annotated French clinical notes. We compare two methods: a method involving French language models and a method involving English language models. For the native French method, the Named Entity Recognition (NER) and normalization steps are performed separately. For the translated English method, after the first translation step, we compare a two-step method and a terminology-oriented method that performs extraction and normalization at the same time. We used French, English and bilingual annotated datasets to evaluate all steps (NER, normalization and translation) of our algorithms. Concerning the results, the native French method performs better than the translated English one with a global f1 score of 0.51 [0.47;0.55] against 0.39 [0.34;0.44] and 0.38 [0.36;0.40] for the two English methods tested. In conclusion, despite the recent improvement of the translation models, there is a significant performance difference between the two approaches in favor of the native French method which is more efficient on French medical texts, even with few annotated documents., Comment: 26 pages, 2 figures, 5 tables
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- 2023
28. Detecting automatically the layout of clinical documents to enhance the performances of downstream natural language processing
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Gérardin, Christel, Wajsbürt, Perceval, Dura, Basile, Calliger, Alice, Moucher, Alexandre, Tannier, Xavier, and Bey, Romain
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Computer Science - Computation and Language - Abstract
Objective:Develop and validate an algorithm for analyzing the layout of PDF clinical documents to improve the performance of downstream natural language processing tasks. Materials and Methods: We designed an algorithm to process clinical PDF documents and extract only clinically relevant text. The algorithm consists of several steps: initial text extraction using a PDF parser, followed by classification into categories such as body text, left notes, and footers using a Transformer deep neural network architecture, and finally an aggregation step to compile the lines of a given label in the text. We evaluated the technical performance of the body text extraction algorithm by applying it to a random sample of documents that were annotated. Medical performance was evaluated by examining the extraction of medical concepts of interest from the text in their respective sections. Finally, we tested an end-to-end system on a medical use case of automatic detection of acute infection described in the hospital report. Results:Our algorithm achieved per-line precision, recall, and F1 score of 98.4, 97.0, and 97.7, respectively, for body line extraction. The precision, recall, and F1 score per document for the acute infection detection algorithm were 82.54 (95CI 72.86-91.60), 85.24 (95CI 76.61-93.70), 83.87 (95CI 76, 92-90.08) with exploitation of the results of the advanced body extraction algorithm, respectively. Conclusion:We have developed and validated a system for extracting body text from clinical documents in PDF format by identifying their layout. We were able to demonstrate that this preprocessing allowed us to obtain better performances for a common downstream task, i.e., the extraction of medical concepts in their respective sections, thus proving the interest of this method on a clinical use case., Comment: 22 pages, 5 figures
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- 2023
29. Lattice calculation of the $\pi^0$, $\eta$ and $\eta^{\prime}$ transition form factors and the hadronic light-by-light contribution to the muon $g-2$
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Gérardin, Antoine, Verplanke, Willem E. A., Wang, Gen, Fodor, Zoltan, Guenther, Jana N., Lellouch, Laurent, Szabo, Kalman K., and Varnhorst, Lukas
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High Energy Physics - Lattice ,High Energy Physics - Phenomenology - Abstract
In this paper we present a first ab-initio calculation of the $\pi^0$, $\eta$ and $\eta^{\prime}$ transition form factors performed with physical light-quark masses. We provide a complete parametrization of the form factors that includes both single and double-virtual kinematics. Our results are compared with experimental measurements of the form factors in the space-like region and with the measured two-photon decay widths. In a second step, our parametrizations of the transition form factors are used to compute the dominant pseudoscalar-pole contributions to the hadronic light-by-light scattering in the muon $g-2$. Our final result reads $a_{\mu}^{\rm hlbl, ps-pole} = (85.1 \pm 5.2) \times 10^{-11}$. Although the pion-pole is dominant, we confirm that, together, the $\eta$ and $\eta^{\prime}$ provide roughly half of its contribution., Comment: 29 pages, 16 figures. Typos corrected. Add figure 6
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- 2023
30. Diagnostic performance of an ultra-sensitive RDT and a conventional RDT in malaria mass testing, treatment and tracking interventions in southern Ghana
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Linda Eva Amoah, Ndong Ignatius Cheng, Festus Kojo Acquah, Susan Adu-Amankwah, Dorcas Gyama Bredu, Benedicta A. Mensah, Sherik-fa Anang, Bernice Cubson Abban, Abena Busayomi, Sebastian Shine Kwarpong, Prosper Kofi Tey, Elizabeth Cudjoe, Alexander Asamoah, Tobias McKenzie Holden, Jaline Gerardin, Justice Nonvignon, and Collins Ahorlu
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Malaria ,RDT ,Ultra-sensitive ,MTTT ,Ghana ,PET-PCR ,Infectious and parasitic diseases ,RC109-216 - Abstract
Abstract Background Application of numerous malaria control interventions has led to reduction in clinical malaria cases and deaths but also the realisation that asymptomatic parasite carriers play a key role in sustaining transmission. This study assessed the effectiveness of using the Ultra-sensitive NxTek eliminate RDT (uRDT) and conventional SD Bioline HRP2 RDT (cRDT) in diagnosing asymptomatic parasitaemia while measuring the impact of mass testing, treatment and tracking (MTTT) on the prevalence of asymptomatic malaria over a 1-year period in Ghana. Methods A total of 4000 targeted participants from two towns, Obom and Kofi Kwei, with their surrounding villages, were tested for asymptomatic malaria four times over the study period using uRDT (intervention) and the cRDT (control) respectively. Participants carrying malaria parasites were followed by home visit and phone calls for compliance to treatment, and filter paper blood blots collected from participants were used to determine true parasite carriage by PET-PCR. A mathematical model of the study site was developed and used to test the impact of test sensitivity and mass migration on the effect of MTTT. Results The start and end point sensitivities of the cRDT were 48.8% and 41.7% and those for the uRDT were 52.9% and 59.9% respectively. After a year of MTTTs, asymptomatic parasite prevalence, as determined by PCR, did not differ statistically in the control site (40.6% to 40.1%, P = 0.730) but decreased at the intervention site (55.9% to 46.4%, P
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- 2024
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31. Evolution and cleaning of the deposit layers on the lower divertor of WEST fully equipped with ITER grade components
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J. Gerardin, Y. Corre, C. Desgranges, M. Diez, L. Dubus, M. Firdaouss, J. Gaspar, A. Grosjean, C. Guillemaut, C. Hernandez, A. Huart, H. Roche, and S. Vives
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ITER-grade W monoblock ,Erosion-redeposition ,Deposit ,Cleaning ,WEST ,Nuclear engineering. Atomic power ,TK9001-9401 - Abstract
After 3 h of accumulated time from repeated plasma shots during C7 campaign performed in 2023, a deposited layer appeared on the ITER-grade W-monoblock of the lower divertor of WEST, mostly on the high field side. The growth of the deposit was observed during the campaign using infrared cameras, showing a large increase of the area covered by the deposit (x4) in the last two hours of cumulated plasma time. The deposit becomes problematic for the operation as it generates flakes which provoke radiative collapse when entering the plasma. A cleaning of the lower divertor is mandatory. A first cleaning was done using adhesive tape to remove all weakly adhered parts of the deposit. This method was chosen because it was easy to implement and did not generate dusts inside the tokamak. The cleaning enables partial removal of the more lightly adhered deposits but a large fraction remains stuck on the monoblock. A second cleaning was tried during 2024 operation by using the plasma as cleaner. A scenario was developed to put the inner strike line directly on the deposit to heat it and try to remove it by thermal stress. The deposit reaches temperature up to 1560°C but was not removed. The impurities generated were higher than normal operation and decreased during the cleaning session (−50% of light impurities observed at the end of the cleaning discharge session), showing an effect of cleaning by removing impurities from the deposit.
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- 2024
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32. Identification of a double decay length (λqt) heat flux deposition shape with embedded thermal measurement and neural network
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Y. Anquetin, J. Gaspar, Y. Corre, JL. Gardarein, J. Gerardin, P. Malard, F. Rigollet, Q. Tichit, and E. Tsitrone
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Tokamak ,WEST ,Divertor ,Heat flux ,Decay length ,Neural network ,Nuclear engineering. Atomic power ,TK9001-9401 - Abstract
The estimation of the heat flux density distribution profiles in tokamak devices is a very important research topic for edge plasma physics purposes and also to ensure the safety of the machine. In the radial direction, the heat flux exhibits an exponential decay that could be captured by thermal sensors distributed in the plasma facing components. Radially distributed thermal sensors based on Fiber Bragg grating technology have been embedded in the WEST lower divertor to study the heat flux deposition profiles during plasma operation. The comparison between embedded measurements and a 3D finite element model shows a small decay length (5 – 10 mm) on top of a wider heat flux with a decay length around 30 to 50 mm. A tool using neural network has been developed in order to predict the values of the different parameters describing the deposited heat flux from embedded temperature measurements in steady state. A large span of deposited heat fluxes with maximum heat flux ranging from 1 to 9 MW/m2 and decay length from 5 to 50 mm were characterized using this tool over a database of more than 250 experimental L-mode pulses performed in WEST in attached divertor configuration. The comparison of the predicted heat flux parameters values with macroscopic plasma parameters have revealed the appearance of the narrow component with the increase of the divertor power load (Pdiv) with a threshold dependant of the plasma current (IP).
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- 2024
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33. LINFOMA DE BURKITT DE VESÍCULA BILIAR EM UMA CRIANÇA VIVENDO COM HIV: RELATO DE CASO
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Nathalia Lopez Duarte, Cristiane Bedran Milito, Ana Paula Silva Bueno, Bárbara Sarni Sanches, Gabriella Alves Ramos, Layanara Albino Batista, Marcelo Gerardin Poirot Land, and Thalita Fernandes de Abreu
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Infectious and parasitic diseases ,RC109-216 ,Microbiology ,QR1-502 - Abstract
Introdução/objetivos: Linfomas de vesícula biliar são particularmente incomuns. Apenas três relatos documentaram linfomas de Burkitt (LB) de vesícula biliar. Este é um relato de caso de LB de vesícula biliar em uma criança vivendo com HIV, o primeiro na literatura na população pediátrica e em indivíduos que vivem com HIV. Materiais e métodos: Relato de caso de criança do sexo feminino, cinco anos de idade, com LB de vesícula biliar. Paciente acompanhada em dois importantes hospitais federais do Rio de Janeiro, Brasil. Análise morfológica e estudo imunohistoquímico da biópsia realizados conforme a OMS, 2022. Resultados: Paciente previamente hígida e sem história familiar para neoplasias. Nasceu em 03/09/94, parto normal, pré-natal completo. Aleitamento materno exclusivo até os dois anos de idade. Em 16/06/99, iniciou quadro de vômitos, dor abdominal, diarreia, icterícia e prurido, além de sintomas B. Internada no 1° Hospital em 20/06/99, diagnosticada com suboclusão intestinal por Ascaris lumbricoides, e desenvolveu colangite grave dias depois apesar do tratamento com albendazol 400 mg, dose única. Submetida à colecistectomia de emergência em 15/07/99. Exame histopatológico pós-operatório da vesícula em 16/07/99 revelou LB, neoplasia definidora de AIDS. Em 28/07/99, realizada sorologia para HIV (ELISA), positiva, e infecção caracterizada como transmissão vertical. Paciente transferida para o 2° Hospital em 31/07/99 para tratamento oncológico (estágio IVB). Por protocolos do período, não fez uso de profilaxias ou terapia antirretroviral (TARV). Em 23/09/00 encontrava-se em remissão clínica ao término da quimioterapia com m-BACOD e, em 04/10/00, apresentou recidiva em sistema nervoso central. Evoluiu com piora clínica progressiva, falecendo por sepse e progressão da doença em 24/12/00. O bloco de parafina foi reavaliado por hematopatologista em 19/08/22, e o diagnóstico confirmado por análise microscópica e estudo imunohistoquímico conforme a OMS, 2022 (positividade para CD20, CD10, Ki67 99%; EBV + via sonda EBER1). Conclusões: O LB pode ocorrer na vesícula biliar tanto no contexto da infecção pelo HIV como na população pediátrica. O diagnóstico final é obtido através da análise histopatológica da biópsia. Além disso, a TARV deve ser iniciada de forma precoce por estar relacionada à recuperação da contagem de células T CD4+ e, consequentemente, à redução da mortalidade pela imunossupressão pelo HIV – como por infecções oportunistas e neoplasias malignas. Palavras-chave: Linfoma de Burkitt, Vesícula Biliar, Soropositividade para HIV, Infecções por Vírus Epstein-Barr, Pediatria. Conflitos de interesse: Não houve conflitos de interesse. Ética e financiamentos: Não houve conflitos de interesse.
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- 2024
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34. The hadronic running of the electromagnetic coupling and electroweak mixing angle
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José, Teseo San, Wittig, Hartmut, Cè, Marco, Gérardin, Antoine, von Hippel, Georg, Meyer, Harvey B., Miura, Kohtaroh, Ottnad, Konstantin, Risch, Andreas, and Wilhelm, Jonas
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High Energy Physics - Lattice ,High Energy Physics - Phenomenology - Abstract
We present results for the hadronic running of the electromagnetic coupling and the weak mixing angle from simulations of lattice QCD with $N_f=2+1$ flavours of $O(a)$-improved Wilson fermions. Using two different discretisations of the vector current, we compute the quark-connected and -disconnected contributions to the hadronic vacuum polarisation (HVP) functions $\bar{\Pi}^{\gamma\gamma}$ and $\bar{\Pi}^{Z\gamma}$ for spacelike squared momenta $Q^2\leq 7$ $\mathrm{GeV}^2$. Our results are extrapolated to the physical point using ensembles at four lattice spacings, with pion masses ranging from 130 to 420 MeV. We observe a tension of up to 3.5 standard deviations between our lattice results for $\Delta\alpha_{\rm had}^{(5)}(-Q^2)$ and estimates based on the $\textit{R}$-ratio for space-like momenta in the range $Q^2=3-7\,\rm GeV^2$. To obtain an estimate for $\Delta\alpha_\mathrm{had}^{(5)}(M_Z^2)$, we employ the Euclidean split technique. The implications for comparison with global electroweak fits are assessed., Comment: 16 pages, 7 figures, proceedings of the 39th International Symposium on Lattice Field Theory, 8th-13th August 2022, Bonn, Germany
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- 2022
35. Intermediate window observable for the hadronic vacuum polarization contribution to the muon $g-2$ from O$(a)$ improved Wilson quarks
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Cè, Marco, Gérardin, Antoine, von Hippel, Georg, Hudspith, Renwick J., Kuberski, Simon, Meyer, Harvey B., Miura, Kohtaroh, Mohler, Daniel, Ottnad, Konstantin, Paul, Srijit, Risch, Andreas, José, Teseo San, and Wittig, Hartmut
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High Energy Physics - Lattice ,High Energy Physics - Phenomenology - Abstract
Following the publication of the new measurement of the anomalous magnetic moment of the muon, the discrepancy between experiment and the theory prediction from the $g-2$ theory initiative has increased to $4.2\,\sigma$. Recent lattice QCD calculations predict values for the hadronic vacuum polarization contribution that are larger than the data-driven estimates, bringing the Standard Model prediction closer to the experimental measurement. Euclidean time windows in the time-momentum representation of the hadronic vacuum polarization contribution to the muon $g-2$ can help clarify the discrepancy between the phenomenological and lattice predictions. We present our calculation of the intermediate distance window contribution using $N_\mathrm{f}=2+1$ flavors of O$(a)$ improved Wilson quarks. We employ ensembles at six lattice spacings below $0.1\,$fm and pion masses down to the physical value. We present a detailed study of the continuum limit, using two discretizations of the vector current and two independent sets of improvement coefficients. Our result at the physical point displays a tension of $3.9\,\sigma$ with a recent evaluation of the intermediate window based on the data-driven method., Comment: 10 pages, 5 figures, Proceedings of the 39th International Symposium on Lattice Field Theory, 8th-13th August 2022, Bonn, Germany
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- 2022
36. The hadronic running of the electroweak couplings from lattice QCD
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Cè, Marco, Gérardin, Antoine, von Hippel, Georg, Meyer, Harvey B., Miura, Kohtaroh, Ottnad, Konstantin, Risch, Andreas, José, Teseo San, and Wittig, Hartmut
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High Energy Physics - Lattice ,High Energy Physics - Phenomenology - Abstract
The energy dependency (running) of the strength of electromagnetic interactions $\alpha$ plays an important role in precision tests of the Standard Model. The running of the former to the $Z$ pole is an input quantity for global electroweak fits, while the running of the mixing angle is susceptible to the effects of Beyond Standard Model physics, particularly at low energies. We present a computation of the hadronic vacuum polarization (HVP) contribution to the running of these electroweak couplings at the non-perturbative level in lattice QCD, in the space-like regime up to $Q^2$ momentum transfers of $7\,\mathrm{GeV}^2$. This quantity is also closely related to the HVP contribution to the muon $g-2$. We observe a tension of up to $3.5$ standard deviation between our lattice results for $\Delta\alpha^{(5)}_{\mathrm{had}}(-Q^2)$ and estimates based on the $R$-ratio for $Q^2$ in the $3$ to $7\,\mathrm{GeV}^2$ range. The tension is, however, strongly diminished when translating our result to the $Z$ pole, by employing the Euclidean split technique and perturbative QCD, which yields $\Delta\alpha^{(5)}_{\mathrm{had}}(M_Z^2)=0.027\,73(15)$. This value agrees with results based on the $R$-ratio within the quoted uncertainties, and can be used as an alternative to the latter in global electroweak fits., Comment: 6 pages, 2 figures, v2: accepted version with minor changes, talk presented at the 41st International Conference on High Energy physics - ICHEP2022
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- 2022
37. Pseudoscalar transition form factors and the hadronic light-by-light contribution to the muon $g-2$
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Gérardin, Antoine, Guenther, Jana N., Varnhorst, Lukas, and Verplanke, Willem E. A.
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High Energy Physics - Lattice ,High Energy Physics - Experiment ,High Energy Physics - Phenomenology - Abstract
We report on our progress toward the computation of the $\pi^0$, $\eta$ and $\eta^{\prime}$ transition form factors using staggered quarks on $N_f=2+1+1$ gauge ensembles generated by the Budapest-Marseille-Wuppertal collaboration. These form factors are essential ingredients to evaluate the pseudoscalar-pole contributions to the hadronic light-by-light scattering in the muon $g-2$. Preliminary results for the pseudoscalar-pole contributions are presented, at finite lattice spacing, for all three light mesons., Comment: 10 pages, 7 figures, contribution to the 39th International Symposium on Lattice Field Theory
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- 2022
38. Hadronic light-by-light scattering contribution to the muon $g-2$ from lattice QCD: semi-analytical calculation of the QED kernel
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Asmussen, Nils, Chao, En-Hung, Gérardin, Antoine, Green, Jeremy R., Hudspith, Renwick J., Meyer, Harvey B., and Nyffeler, Andreas
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High Energy Physics - Lattice ,High Energy Physics - Phenomenology ,High Energy Physics - Theory - Abstract
Hadronic light-by-light scattering is one of the virtual processes that causes the gyromagnetic factor $g$ of the muon to deviate from the value of two predicted by Dirac's theory. This process makes one of the largest contributions to the uncertainty of the Standard Model prediction for the muon $(g-2)$. Lattice QCD allows for a first-principles approach to computing this non-perturbative effect. In order to avoid power-law finite-size artifacts generated by virtual photons in lattice simulations, we follow a coordinate-space approach involving a weighted integral over the vertices of the QCD four-point function of the electromagnetic current carried by the quarks. Here we present in detail the semi-analytical calculation of the QED part of the amplitude, employing position-space perturbation theory in continuous, infinite four-dimensional Euclidean space. We also provide some useful information about a computer code for the numerical implementation of our approach that has been made public at https://github.com/RJHudspith/KQED., Comment: 84 pages, 13 figures; text matches the published version
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- 2022
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39. Lumacaftor/Ivacaftor Population Pharmacokinetics in Pediatric Patients with Cystic Fibrosis: A First Step Toward Personalized Therapy
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Bouazza, Naïm, Urien, Saïk, Foissac, Frantz, Choupeaux, Laure, Lui, Gabrielle, Froelicher Bournaud, Léo, Rouillon, Steeve, Zheng, Yi, Bardin, Emmanuelle, Stremler, Nathalie, Bessaci, Katia, Bihouee, Tiphaine, Coirier-Duet, Emmanuelle, Marguet, Christophe, Deneuville, Eric, Laurans, Muriel, Reix, Philippe, Gerardin, Michèle, Mittaine, Marie, Epaud, Ralph, Thumerelle, Caroline, Weiss, Laurence, Berthaud, Romain, Semeraro, Michaela, Treluyer, Jean-Marc, Benaboud, Sihem, and Sermet-Gaudelus, Isabelle
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- 2024
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40. AI powered quantification of nuclear morphology in cancers enables prediction of genome instability and prognosis
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John Abel, Suyog Jain, Deepta Rajan, Harshith Padigela, Kenneth Leidal, Aaditya Prakash, Jake Conway, Michael Nercessian, Christian Kirkup, Syed Ashar Javed, Raymond Biju, Natalia Harguindeguy, Daniel Shenker, Nicholas Indorf, Darpan Sanghavi, Robert Egger, Benjamin Trotter, Ylaine Gerardin, Jacqueline A. Brosnan-Cashman, Aditya Dhoot, Michael C. Montalto, Chintan Parmar, Ilan Wapinski, Archit Khosla, Michael G. Drage, Limin Yu, and Amaro Taylor-Weiner
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Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract While alterations in nucleus size, shape, and color are ubiquitous in cancer, comprehensive quantification of nuclear morphology across a whole-slide histologic image remains a challenge. Here, we describe the development of a pan-tissue, deep learning-based digital pathology pipeline for exhaustive nucleus detection, segmentation, and classification and the utility of this pipeline for nuclear morphologic biomarker discovery. Manually-collected nucleus annotations were used to train an object detection and segmentation model for identifying nuclei, which was deployed to segment nuclei in H&E-stained slides from the BRCA, LUAD, and PRAD TCGA cohorts. Interpretable features describing the shape, size, color, and texture of each nucleus were extracted from segmented nuclei and compared to measurements of genomic instability, gene expression, and prognosis. The nuclear segmentation and classification model trained herein performed comparably to previously reported models. Features extracted from the model revealed differences sufficient to distinguish between BRCA, LUAD, and PRAD. Furthermore, cancer cell nuclear area was associated with increased aneuploidy score and homologous recombination deficiency. In BRCA, increased fibroblast nuclear area was indicative of poor progression-free and overall survival and was associated with gene expression signatures related to extracellular matrix remodeling and anti-tumor immunity. Thus, we developed a powerful pan-tissue approach for nucleus segmentation and featurization, enabling the construction of predictive models and the identification of features linking nuclear morphology with clinically-relevant prognostic biomarkers across multiple cancer types.
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- 2024
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41. Consistency in Young’s Modulus of Powders: A Review with Experiments
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Maria-Graciela Cares-Pacheco, Ellen Cordeiro-Silva, Fabien Gerardin, and Veronique Falk
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Young’s modulus ,elasticity ,compression ,compaction ,vibration ,porosity ,Chemistry ,QD1-999 - Abstract
This review, complemented by empirical investigations, delves into the intricate world of industrial powders, examining their elastic properties through diverse methodologies. The study critically assesses Young’s modulus (E) across eight different powder samples from various industries, including joint filler, wheat flour, wheat starch, gluten, glass beads, and sericite. Employing a multidisciplinary approach, integrating uniaxial compression methodologies—both single and cyclic—with vibration techniques, has revealed surprising insights. Particularly notable is the relationship between porosity and Young’s modulus, linking loose powders to the compacts generated under compression methods. Depending on the porosity of the powder bed, Young’s modulus can vary from a few MPa (loose powder) to several GPa (tablet), following an exponential trend. The discussion emphasizes the necessity of integrating various techniques, with a specific focus on the consolidation state of the powder bed, to achieve a comprehensive understanding of bulk elasticity. This underscores the need for low-consolidation methodologies that align more closely with powder technologies and unit operations such as conveying, transport, storage, and feeding. In conclusion, the study suggests avenues for further research, highlighting the importance of exploring bulk elastic properties in loose packing conditions, their relation with flowability, alongside the significance of powder conditioning.
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- 2024
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42. Forward light-by-light scattering and electromagnetic correction to hadronic vacuum polarization
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Biloshytskyi, Volodymyr, Chao, En-Hung, Gérardin, Antoine, Green, Jeremy R., Hagelstein, Franziska, Meyer, Harvey B., Parrino, Julian, and Pascalutsa, Vladimir
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High Energy Physics - Lattice ,High Energy Physics - Phenomenology - Abstract
Lattice QCD calculations of the hadronic vacuum polarization (HVP) have reached a precision where the electromagnetic (e.m.) correction can no longer be neglected. This correction is both computationally challenging and hard to validate, as it leads to ultraviolet (UV) divergences and to sizeable infrared (IR) effects associated with the massless photon. While we precisely determine the UV divergence using the operator-product expansion, we propose to introduce a separation scale $\Lambda\sim400\;$MeV into the internal photon propagator, whereby the calculation splits into a short-distance part, regulated in the UV by the lattice and in the IR by the scale $\Lambda$, and a UV-finite long-distance part to be treated with coordinate-space methods, thereby avoiding power-law finite-size effects altogether. In order to predict the long-distance part, we express the UV-regulated e.m. correction to the HVP via the forward hadronic light-by-light (HLbL) scattering amplitude and relate the latter via a dispersive sum rule to $\gamma^*\gamma^*$ fusion cross-sections. Having tested the relation by reproducing the two-loop QED vacuum polarization (VP) from the tree-level $\gamma^*\gamma^*\to e^+e^-$ cross-section, we predict the expected lattice-QCD integrand resulting from the $\gamma^*\gamma^*\to\pi^0$ process., Comment: 29 pages, 6 figures; text matches the published version
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- 2022
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43. Balloon pulmonary angioplasty for proximal chronic thromboembolic pulmonary hypertension in patients ineligible for pulmonary endarterectomy
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Justin Issard, Elie Fadel, Samuel Dolidon, Benoit Gerardin, Dominique Fabre, Delphine Mitilian, Olaf Mercier, Mitja Jevnikar, Xavier Jais, Marc Humbert, and Philippe Brenot
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morbidity ,pulmonary endarterectomy ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 ,Diseases of the respiratory system ,RC705-779 - Abstract
Abstract Balloon pulmonary angioplasty (BPA) to treat chronic thromboembolic pulmonary hypertension (CTEPH) is generally reserved for distal obstruction precluding pulmonary endarterectomy (PEA) but can be used in patients with proximal disease who are at high surgical risk or refuse surgery. This single‐center retrospective study compared BPA efficacy in patients with proximal versus distal CTEPH. Of the 478 patients, 36 had proximal disease, follow‐up was 11.6 months and mean number of BPA 6. After BPA, PVR, and mean pulmonary artery pressure decreased significantly in the proximal and distal groups (from 6.5 to 4.0 WU and 39 to 31 mmHg and from 7.6 to 3.8 WU and 44 to 31 mmHg, respectively, p
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- 2024
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44. Window observable for the hadronic vacuum polarization contribution to the muon $g-2$ from lattice QCD
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Cè, Marco, Gérardin, Antoine, von Hippel, Georg, Hudspith, Renwick J., Kuberski, Simon, Meyer, Harvey B., Miura, Kohtaroh, Mohler, Daniel, Ottnad, Konstantin, Paul, Srijit, Risch, Andreas, José, Teseo San, and Wittig, Hartmut
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High Energy Physics - Lattice ,High Energy Physics - Phenomenology - Abstract
Euclidean time windows in the integral representation of the hadronic vacuum polarization contribution to the muon $g-2$ serve to test the consistency of lattice calculations and may help in tracing the origins of a potential tension between lattice and data-driven evaluations. In this paper, we present results for the intermediate time window observable computed using O($a$) improved Wilson fermions at six values of the lattice spacings below 0.1\,fm and pion masses down to the physical value. Using two different sets of improvement coefficients in the definitions of the local and conserved vector currents, we perform a detailed scaling study which results in a fully controlled extrapolation to the continuum limit without any additional treatment of the data, except for the inclusion of finite-volume corrections. To determine the latter, we use a combination of the method of Hansen and Patella and the Meyer-Lellouch-L\"uscher procedure employing the Gounaris-Sakurai parameterization for the pion form factor. We correct our results for isospin-breaking effects via the perturbative expansion of QCD+QED around the isosymmetric theory. Our result at the physical point is $a_\mu^{\mathrm{win}}=(237.30\pm0.79_{\rm stat}\pm1.22_{\rm syst})\times10^{-10}$, where the systematic error includes an estimate of the uncertainty due to the quenched charm quark in our calculation. Our result displays a tension of 3.9$\sigma$ with a recent evaluation of $a_\mu^{\mathrm{win}}$ based on the data-driven method., Comment: 43 pages, 9 figures, 10 tables; version accepted for publication: extended discussion of finite-volume corrections. Results and conclusions unchanged
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- 2022
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45. The charm-quark contribution to light-by-light scattering in the muon $(g-2)$ from lattice QCD
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Chao, En-Hung, Hudspith, Renwick J., Gérardin, Antoine, Green, Jeremy R., and Meyer, Harvey B.
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High Energy Physics - Lattice ,High Energy Physics - Phenomenology - Abstract
We compute the hadronic light-by-light scattering contribution to the muon $g-2$ from the charm quark using lattice QCD. The calculation is performed on ensembles generated with dynamical $(u,d,s)$ quarks at the SU(3)$_{\rm f}$ symmetric point with degenerate pion and kaon masses of around 415 MeV. It includes the connected charm contribution, as well as the leading disconnected Wick contraction, involving the correlation between a charm and a light-quark loop. Cutoff effects turn out to be sizeable, which leads us to use lighter-than-physical charm masses, to employ a broad range of lattice spacings reaching down to 0.039 fm and to perform a combined charm-mass and continuum extrapolation. We use the $\eta_c$ meson to define the physical charm-mass point and obtain a final value of $a_\mu^{\rm HLbL,c} = (2.8\pm 0.5) \times 10^{-11}$, whose uncertainty is dominated by the systematics of the extrapolation. Our result is consistent with the estimate based on a simple charm-quark loop, whilst being free of any perturbative scheme dependence on the charm mass. The mixed charm-light disconnected contraction contributes a small negative amount to the final value., Comment: 21 pages, 8 figures, 9 tables
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- 2022
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46. 'Naloxone? Not for me!' First cross-assessment by patients and healthcare professionals of the risk of opioid overdose
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Aurélie Aquizerate, Morgane Rousselet, Axel Cochard, Marylène Guerlais, Marie Gerardin, Emilie Lefebvre, Mélanie Duval, Edouard-Jules Laforgue, and Caroline Victorri-Vigneau
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Naloxone ,Opioid overdose ,Cross-assessment ,Opioid substitution treatment ,Public aspects of medicine ,RA1-1270 - Abstract
Abstract Background Opioid-related mortality is a rising public health concern in France, where opioids were in 2021 implicated in 75% of overdose deaths. Opioid substitution treatment (OST) was implicated in almost half of deaths related to substance and drug abuse. Although naloxone could prevent 80% of these deaths, there are a number of barriers to the distribution of take-home naloxone (THN) among opioid users in France. This study is the first one which compares patients' self-assessment of the risk of future opioid overdose with the hetero-assessment provided by healthcare professionals in a population of individuals eligible for naloxone. Methods This was a multicenter descriptive observational study carried out in pharmacies across the Pays de la Loire region (France) during April and May 2022. All adult patients who visited a participating pharmacy for a prescription of OST and provided oral informed consent were enrolled in the study. Retrospective data were collected through cross-sectional interviews conducted by the pharmacist with the patient, utilizing an ad hoc questionnaire. The patient’s self-assessment of overdose risk was evaluated using a Likert scale from 0 to 10. The pharmacist relied on the presence or absence of overdose risk situations defined by the French Health Authority (HAS). The need to hold THN was assessed using a composite criterion. Results A total of 34 patients were interviewed; near one third were aware of the existence of THN and a minority had THN in their possession. Out of the 34 participants, 29 assessed their own risk of future opioid overdose: 65.5% reported having zero risk, while 6.9% believed they had a high risk. Nevertheless, at least one risk situation of opioid overdose was identified according to HAS criteria in 73.5% of the participants (n = 25). Consequently, 55% of the participants underestimated their risk of experiencing a future opioid overdose. Yet, dispensing THN has been judged necessary for 88.2% of the participants. Conclusion This study underscored the imperative need to inform not only healthcare professionals but also the patients and users themselves on the availability of THN and the risk situations of opioid overdose.
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- 2024
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47. Prospects for precise predictions of $a_\mu$ in the Standard Model
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Colangelo, G., Davier, M., El-Khadra, A. X., Hoferichter, M., Lehner, C., Lellouch, L., Mibe, T., Roberts, B. L., Teubner, T., Wittig, H., Ananthanarayan, B., Bashir, A., Bijnens, J., Blum, T., Boyle, P., Bray-Ali, N., Caprini, I., Calame, C. M. Carloni, Catà, O., Cè, M., Charles, J., Christ, N. H., Curciarello, F., Danilkin, I., Das, D., Deineka, O., Della Morte, M., Denig, A., DeTar, C. E., Dominguez, C. A., Eichmann, G., Fischer, C. S., Gérardin, A., Giusti, D., Golterman, M., Gottlieb, Steven, Gülpers, V., Hagelstein, F., Hayakawa, M., Hermansson-Truedsson, N., Hoid, B. -L., Holz, S., Izubuchi, T., Jüttner, A., Keshavarzi, A., Knecht, M., Kronfeld, A. S., Kubis, B., Kupść, A., Lahert, S., Liu, K. F., Lüdtke, J., Lynch, M., Malaescu, B., Maltman, K., Marciano, W., Marinković, M. K., Masjuan, P., Meyer, H. B., Müller, S. E., Neil, E. T., Passera, M., Pepe, M., Peris, S., Petrov, A. A., Procura, M., Raya, K., Rebhan, A., Risch, A., Rodríguez-Sánchez, A., Roig, P., Sánchez-Puertas, P., Simula, S., Stoffer, P., Stokes, F. M., Sugar, R., Tsang, J. T., van de Water, R. S., Avilés-Casco, A. Vaquero, Venanzoni, G., von Hippel, G. M., and Zhang, Z.
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High Energy Physics - Phenomenology ,High Energy Physics - Experiment ,High Energy Physics - Lattice ,Nuclear Experiment ,Nuclear Theory - Abstract
We discuss the prospects for improving the precision on the hadronic corrections to the anomalous magnetic moment of the muon, and the plans of the Muon $g-2$ Theory Initiative to update the Standard Model prediction., Comment: Contribution to the US Community Study on the Future of Particle Physics (Snowmass 2021)
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- 2022
48. Weight of single and recurrent scattering in the reflection matrix of complex media
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Brütt, Cécile, Aubry, Alexandre, Gérardin, Benoît, Derode, Arnaud, and Prada, Claire
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Physics - Applied Physics ,Condensed Matter - Disordered Systems and Neural Networks - Abstract
In a heterogeneous medium, the wavefield can be decomposed as an infinite series known as the Born expansion. Each term of the Born expansion corresponds to a scattering order, it is thus theoretically possible to discriminate single and multiple scattering field components. Experimentally, what is actually measured is the total field in which all scattering orders interfere. Conventional imaging methods usually rely on the assumption that the multiple scattering contribution can be disregarded. In a back-scattering configuration, this assumption is valid for small depths, and begins to fail for depths larger than the scattering mean-free path $\ell_s$. It is therefore a key issue to estimate the relative amount of single and multiple scattering in experimental data. To this end, a single scattering estimator $\hat{\rho}$ computed from the reflection matrix has been introduced in order to assess the weight of single scattering in the backscattered wavefield. In this article, the meaning of this estimator is investigated and a particular attention is given to recurrent scattering. In a diffraction-limited experiment, a multiple scattering sequence is said to be recurrent if the first and last scattering events occur in the same resolution cell. Recurrent scattering is shown to be responsible for correlations between single scattering and higher scattering orders of the Born expansion, inducing a bias to the estimator $\hat{\rho}$ that should rather be termed confocal scattering ratio. Interestingly, a more robust estimator is built by projecting the reflection matrix in a focused basis. The argument is sustained by numerical simulations as well as ultrasonic data obtained around 1.5~MHz in a model medium made of nylon rods immersed in water. From a more general perspective, this work raises fundamental questions about the impact of recurrent scattering on wave imaging., Comment: 17 pages, 11 figures
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- 2022
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49. The hadronic running of the electromagnetic coupling and the electroweak mixing angle from lattice QCD
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Cè, Marco, Gérardin, Antoine, von Hippel, Georg, Meyer, Harvey B., Miura, Kohtaroh, Ottnad, Konstantin, Risch, Andreas, José, Teseo San, Wilhelm, Jonas, and Wittig, Hartmut
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High Energy Physics - Lattice ,High Energy Physics - Phenomenology - Abstract
We compute the hadronic running of the electromagnetic and weak couplings in lattice QCD with $N_{\mathrm{f}}=2+1$ flavors of $\mathcal{O}(a)$ improved Wilson fermions. Using two different discretizations of the vector current, we compute the quark-connected and -disconnected contributions to the hadronic vacuum polarization (HVP) functions $\bar{\Pi}^{\gamma\gamma}$ and $\bar{\Pi}^{\gamma Z}$ for Euclidean squared momenta $Q^2\leq 7\,\mathrm{GeV}^2$. Gauge field ensembles at four values of the lattice spacing and several values of the pion mass, including its physical value, are used to extrapolate the results to the physical point. The ability to perform an exact flavor decomposition allows us to present the most precise determination to date of the $\mathrm{SU}(3)$-flavor-suppressed HVP function $\bar{\Pi}^{08}$ that enters the running of $\sin^2\theta_{\mathrm{W}}$. Our results for $\bar{\Pi}^{\gamma\gamma}$, $\bar{\Pi}^{\gamma Z}$ and $\bar{\Pi}^{08}$ are presented in terms of rational functions for continuous values of $Q^2$ below $7 \,\mathrm{GeV}^2$. We observe a tension of up to $3.5$ standard deviation between our lattice results for $\Delta\alpha^{(5)}_{\mathrm{had}}(-Q^2)$ and estimates based on the $R$-ratio for space-like momenta in the range $3$--$7\,\mathrm{GeV}^2$. The tension is, however, strongly diminished when translating our result to the $Z$ pole, by employing the Euclidean split technique and perturbative QCD, which yields $\Delta\alpha^{(5)}_{\mathrm{had}}(M_Z^2)=0.027\,73(15)$ and agrees with results based on the $R$-ratio within the quoted uncertainties., Comment: 63 pages, 17 figures, 11 tables. v2: version accepted for publication in JHEP
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- 2022
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50. Effect of Virtual Aortic Arch Reconstruction After Norwood Procedure on Cardiac Function, Energy Efficiency, and Wall Shear Stress from Multiscale Simulations
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Blanch-Granada, Aloma, Samyn, Margaret M., Handler, Stephanie S., Gerardin, Jennifer F, Goot, Benjamin, Hraška, Viktor, Cava, Joseph R., and LaDisa, Jr, John F.
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- 2023
- Full Text
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