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14 results on '"Gerasymchuk, Marta"'

3. Psilocybin and Eugenol Reduce Inflammation in Human 3D EpiIntestinal Tissue.

Author

Robinson, Gregory Ian, Li, Dongping, Wang, Bo, Rahman, Tahiat, Gerasymchuk, Marta, Hudson, Darryl, Kovalchuk, Olga, and Kovalchuk, Igor

Subjects
PSILOCYBIN, SEROTONIN, EUGENOL, INFLAMMATORY bowel diseases, TUMOR necrosis factors, TRP channels, SEROTONIN receptors
Abstract

Inflammation plays a pivotal role in the development and progression of inflammatory bowel disease (IBD), by contributing to tissue damage and exacerbating the immune response. The investigation of serotonin receptor 2A (5-HT2A) ligands and transient receptor potential (TRP) channel ligands is of significant interest due to their potential to modulate key inflammatory pathways, mitigate the pathological effects of inflammation, and offer new avenues for therapeutic interventions in IBD. This study investigates the anti-inflammatory effects of 5-HT2A ligands, including psilocybin, 4-AcO-DMT, and ketanserin, in combination with TRP channel ligands, including capsaicin, curcumin, and eugenol, on the inflammatory response induced by tumor necrosis factor (TNF)-α and interferon (IFN)-γ in human 3D EpiIntestinal tissue. Enzyme-linked immunosorbent assay was used to assess the expression of pro-inflammatory markers TNF-α, IFN-γ, IL-6, IL-8, MCP-1, and GM-CSF. Our results show that psilocybin, 4-AcO-DMT, and eugenol significantly reduce TNF-α and IFN-γ levels, while capsaicin and curcumin decrease these markers to a lesser extent. Psilocybin effectively lowers IL-6 and IL-8 levels, but curcumin, capsaicin, and 4-AcO-DMT have limited effects on these markers. In addition, psilocybin can significantly decrease MCP-1 and GM-CSF levels. While ketanserin lowers IL-6 and GM-CSF levels, there are no effects seen on TNF-α, IFN-γ, IL-8, or MCP-1. Although synergistic effects between 5-HT2A and TRP channel ligands are minimal in this study, the results provide further evidence of the anti-inflammatory effects of psilocybin and eugenol. Further research is needed to understand the mechanisms of action and the feasibility of using these compounds as anti-inflammatory therapies for conditions like IBD. [ABSTRACT FROM AUTHOR]

Published
2023
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5. Sex-Dependent Skin Aging and Rejuvenation Strategies

Author

Gerasymchuk, Marta, primary, Robinson, Gregory Ian, additional, Vardinska, Nataliia, additional, Ayedun, Samuel Abiola, additional, Alozie, Sandra Chinwe, additional, Robinson, John Wesley, additional, Kovalchuk, Olga, additional, and Kovalchuk, Igor, additional

Published
2023
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6. The Effect of Combined Treatment of Psilocybin and Eugenol on Lipopolysaccharide-Induced Brain Inflammation in Mice

Author

Zanikov, Timur, primary, Gerasymchuk, Marta, additional, Ghasemi Gojani, Esmaeel, additional, Robinson, Gregory Ian, additional, Asghari, Shima, additional, Groves, Alyssa, additional, Haselhorst, Lucie, additional, Nandakumar, Sanjana, additional, Stahl, Cora, additional, Cameron, Mackenzie, additional, Li, Dongping, additional, Rodriguez-Juarez, Rocio, additional, Snelling, Alexandra, additional, Hudson, Darryl, additional, Fiselier, Anna, additional, Kovalchuk, Olga, additional, and Kovalchuk, Igor, additional

Published
2023
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8. Copper sulphate inhibits Penicillium olsoniigrowth and conidiogenesis on Cannabis sativa

Author

Farahmand, Hamed, Robinson, Gregory Ian, Gerasymchuk, Marta, and Kovalchuk, Igor

Abstract

Fungal infections of Cannabis sativaare common and can severely affect yields, however, few studies have examined the use of fungicides for cannabis production. Copper (II) sulphate is an age-old fungicide that has been used to impede fungal diseases in multiple crops. This study aims to test the efficacy of copper sulphate against common cannabis fungal pathogens. Fungi were isolated from cannabis leaves and the most prevalent fungal pathogen obtained was Penicillium olsonii. P. olsoniiwas grown in vitroon potato dextrose agar (PDA) supplemented with various concentrations of copper sulphate (0–300 mg/L). The lowest concentration with a significant decrease in growth was 75 mg/L, while the half maximal effective concentration (EC50) and minimum inhibitory concentration (MIC) was calculated to be 73.1 mg/L and 474.9 mg/L, respectively. Healthy cannabis plants were inoculated with P. olsoniiand sprayed biweekly with copper sulphate (0 or 100 mg/L). After four weeks of foliar applications, genomic DNA was isolated from infected cannabis leaves and qPCR analysis showed P. olsoniilevels were significantly lower when treated with copper sulphate (100 mg/L) compared to the control. Conidia from infected leaves were isolated, stained, and counted. Copper sulphate treatment significantly reduced conidiogenesis compared to the control. This is the first report showing foliar applications of copper sulphate on C. sativacan reduce fungal disease and prevent the deterioration of cannabis yields.

Published
2023
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