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4 results on '"Gereon Schaelte"'

1. Genome-wide association study of myocardial infarction, atrial fibrillation, acute stroke, acute kidney injury and delirium after cardiac surgery – a sub-analysis of the RIPHeart-Study

Author

Sabine Westphal, Christian Stoppe, Matthias Gruenewald, Berthold Bein, Jochen Renner, Jochen Cremer, Mark Coburn, Gereon Schaelte, Andreas Boening, Bernd Niemann, Frank Kletzin, Jan Roesner, Ulrich Strouhal, Christian Reyher, Rita Laufenberg-Feldmann, Marion Ferner, Ivo F. Brandes, Martin Bauer, Andreas Kortgen, Sebastian N. Stehr, Maria Wittmann, Georg Baumgarten, Rafael Struck, Tanja Meyer-Treschan, Peter Kienbaum, Matthias Heringlake, Julika Schoen, Michael Sander, Sascha Treskatsch, Thorsten Smul, Ewa Wolwender, Thomas Schilling, Frauke Degenhardt, Andre Franke, Soeren Mucha, Lukas Tittmann, Madeline Kohlhaas, Georg Fuernau, Oana Brosteanu, Dirk Hasenclever, Kai Zacharowski, Patrick Meybohm, and RIPHeart-Study Collaborators

Subjects
Genome-wide association study, Cardiac surgery, Atrial fibrillation, Delirium, Myocardial infarction, Acute kidney injury, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Abstract Background The aim of our study was the identification of genetic variants associated with postoperative complications after cardiac surgery. Methods We conducted a prospective, double-blind, multicenter, randomized trial (RIPHeart). We performed a genome-wide association study (GWAS) in 1170 patients of both genders (871 males, 299 females) from the RIPHeart-Study cohort. Patients undergoing non-emergent cardiac surgery were included. Primary endpoint comprises a binary composite complication rate covering atrial fibrillation, delirium, non-fatal myocardial infarction, acute renal failure and/or any new stroke until hospital discharge with a maximum of fourteen days after surgery. Results A total of 547,644 genotyped markers were available for analysis. Following quality control and adjustment for clinical covariate, one SNP reached genome-wide significance (PHLPP2, rs78064607, p = 3.77 × 10− 8) and 139 (adjusted for all other outcomes) SNPs showed promising association with p

Published
2019
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2. RIPHeart (Remote Ischemic Preconditioning for Heart Surgery) Study: Myocardial Dysfunction, Postoperative Neurocognitive Dysfunction, and 1 Year Follow‐Up

Author

Patrick Meybohm, Madeline Kohlhaas, Christian Stoppe, Matthias Gruenewald, Jochen Renner, Berthold Bein, Martin Albrecht, Jochen Cremer, Mark Coburn, Gereon Schaelte, Andreas Boening, Bernd Niemann, Michael Sander, Jan Roesner, Frank Kletzin, Haitham Mutlak, Sabine Westphal, Rita Laufenberg‐Feldmann, Marion Ferner, Ivo F. Brandes, Martin Bauer, Sebastian N. Stehr, Andreas Kortgen, Maria Wittmann, Georg Baumgarten, Tanja Meyer‐Treschan, Peter Kienbaum, Matthias Heringlake, Julika Schoen, Sascha Treskatsch, Thorsten Smul, Ewa Wolwender, Thomas Schilling, Georg Fuernau, Holger Bogatsch, Oana Brosteanu, Dirk Hasenclever, and Kai Zacharowski

Subjects
cardio‐vascular surgery, ischemia/reperfusion injury, remote ischemic preconditioning, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

BackgroundRemote ischemic preconditioning (RIPC) has been suggested to protect against certain forms of organ injury after cardiac surgery. Previously, we reported the main results of RIPHeart (Remote Ischemic Preconditioning for Heart Surgery) Study, a multicenter trial randomizing 1403 cardiac surgery patients receiving either RIPC or sham‐RIPC. Methods and ResultsIn this follow‐up paper, we present 1‐year follow‐up of the composite primary end point and its individual components (all‐cause mortality, myocardial infarction, stroke and acute renal failure), in a sub‐group of patients, intraoperative myocardial dysfunction assessed by transesophageal echocardiography and the incidence of postoperative neurocognitive dysfunction 5 to 7 days and 3 months after surgery. RIPC neither showed any beneficial effect on the 1‐year composite primary end point (RIPC versus sham‐RIPC 16.4% versus 16.9%) and its individual components (all‐cause mortality [3.4% versus 2.5%], myocardial infarction [7.0% versus 9.4%], stroke [2.2% versus 3.1%], acute renal failure [7.0% versus 5.7%]) nor improved intraoperative myocardial dysfunction or incidence of postoperative neurocognitive dysfunction 5 to 7 days (67 [47.5%] versus 71 [53.8%] patients) and 3 months after surgery (17 [27.9%] versus 18 [27.7%] patients), respectively. ConclusionsSimilar to our main study, RIPC had no effect on intraoperative myocardial dysfunction, neurocognitive function and long‐term outcome in cardiac surgery patients undergoing propofol anesthesia. Clinical Trial RegistrationURL: https://www.clinicaltrials.gov. Unique identifier: NCT01067703.

Published
2018
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3. Combining Minimally Invasive Surgery With Ultra-Fast-Track Anesthesia in HeartMate 3 Patients: A Pilot Study

Author

Usaama Ahmad, Mohammad Amen Khattab, Gereon Schaelte, Andreas Goetzenich, Ann C. Foldenauer, Ajay Moza, Lachmandath Tewarie, Christian Stoppe, Rüdiger Autschbach, Heike Schnoering, Rashad Zayat, and Publica

Subjects
Heart Failure, heart-assist devices, Treatment Outcome, Minimally Invasive Surgical Procedures, Anesthesia, pilot projects, humans, Cardiology and Cardiovascular Medicine, propensity score, Retrospective Studies, sternotomy
Abstract

Background: Minimally invasive surgery for left ventricular assist device implantation may have advantages over conventional sternotomy (CS). Additionally, ultra-fast-track anesthesia has been linked to better outcomes after cardiac surgery. This study summarizes our early experience of combining minimally invasive surgery with ultra-fast-track anesthesia (MIFTA) in patients receiving HeartMate 3 devices and compares the outcomes between MIFTA and CS. Methods: From October 2015 to January 2019, 18 of 49 patients with Interagency Registry for Mechanically Assisted Circulatory Support profiles >1 underwent MIFTA for HeartMate 3 implantation. For bias reduction, propensity scores were calculated and used as a covariate in a regression model to analyze outcomes. Weighted parametric survival analysis was performed. Results: In the MIFTA group, intensive care unit stays were shorter (mean difference, 8 days [95% CI, 4–13]; P P =0.016, respectively). At 6 and 12 hours postoperatively, MIFTA patients had a better hemodynamic performance with lower pulmonary wedge pressure (mean difference, 2.23 mm Hg [95% CI, 0.41–4.06]; P =0.028) and a higher right ventricular stroke work index (mean difference, −1.49 g·m/m 2 per beat [95% CI, −2.95 to −0.02]; P =0.031). CS patients had a worse right heart failure–free survival rate (hazard ratio, 2.35 [95% CI, 0.96–5.72]; P Conclusions: Compared with CS, MIFTA is a beneficial approach for non–Interagency Registry for Mechanically Assisted Circulatory Support 1 HeartMate 3 patients with lower adverse event incidences, better hemodynamic performance, and preserved right heart function. Future large multicentric investigations are required to verify MIFTA’s effects on outcomes.

Published
2022
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4. Genome-wide association study of myocardial infarction, atrial fibrillation, acute stroke, acute kidney injury and delirium after cardiac surgery - a sub-analysis of the RIPHeart-Study

Author

Sabine, Westphal, Christian, Stoppe, Matthias, Gruenewald, Berthold, Bein, Jochen, Renner, Jochen, Cremer, Mark, Coburn, Gereon, Schaelte, Andreas, Boening, Bernd, Niemann, Frank, Kletzin, Jan, Roesner, Ulrich, Strouhal, Christian, Reyher, Rita, Laufenberg-Feldmann, Marion, Ferner, Ivo F, Brandes, Martin, Bauer, Andreas, Kortgen, Sebastian N, Stehr, Maria, Wittmann, Georg, Baumgarten, Rafael, Struck, Tanja, Meyer-Treschan, Peter, Kienbaum, Matthias, Heringlake, Julika, Schoen, Michael, Sander, Sascha, Treskatsch, Thorsten, Smul, Ewa, Wolwender, Thomas, Schilling, Frauke, Degenhardt, Andre, Franke, Soeren, Mucha, Lukas, Tittmann, Madeline, Kohlhaas, Georg, Fuernau, Oana, Brosteanu, Dirk, Hasenclever, Kai, Zacharowski, Patrick, Meybohm, and Norbert, Roewer

Subjects
Male, lcsh:Diseases of the circulatory (Cardiovascular) system, Myocardial Infarction, 030204 cardiovascular system & hematology, 0302 clinical medicine, Risk Factors, Atrial Fibrillation, Clinical endpoint, Phosphoprotein Phosphatases, Multicenter Studies as Topic, 030212 general & internal medicine, Myocardial infarction, Stroke, Randomized Controlled Trials as Topic, Acute kidney injury, Atrial fibrillation, Acute Kidney Injury, Middle Aged, Cardiac surgery, 3. Good health, Treatment Outcome, Cohort, Cardiology, Dual-Specificity Phosphatases, Female, medicine.symptom, Cardiology and Cardiovascular Medicine, Research Article, medicine.medical_specialty, Genome-wide association study, Polymorphism, Single Nucleotide, 03 medical and health sciences, Internal medicine, medicine, Humans, Genetic Predisposition to Disease, Cardiac Surgical Procedures, Aged, business.industry, HSC70 Heat-Shock Proteins, Delirium, Ryanodine Receptor Calcium Release Channel, medicine.disease, Cytoskeletal Proteins, lcsh:RC666-701, Mitogen-Activated Protein Kinase Phosphatases, business
Abstract

Background The aim of our study was the identification of genetic variants associated with postoperative complications after cardiac surgery. Methods We conducted a prospective, double-blind, multicenter, randomized trial (RIPHeart). We performed a genome-wide association study (GWAS) in 1170 patients of both genders (871 males, 299 females) from the RIPHeart-Study cohort. Patients undergoing non-emergent cardiac surgery were included. Primary endpoint comprises a binary composite complication rate covering atrial fibrillation, delirium, non-fatal myocardial infarction, acute renal failure and/or any new stroke until hospital discharge with a maximum of fourteen days after surgery. Results A total of 547,644 genotyped markers were available for analysis. Following quality control and adjustment for clinical covariate, one SNP reached genome-wide significance (PHLPP2, rs78064607, p = 3.77 × 10− 8) and 139 (adjusted for all other outcomes) SNPs showed promising association with p

Published
2018

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