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3. TECHNOLOGICAL DIGITAL RESOURCES AND THE WORK WITH GENRES IN EFL TEXTBOOKS.

Author

VIEIRA, Gicele Vergine and GERLACH, Alana Motta

Subjects
ONLINE social networks, GENRE studies, VIDEO editing, TEXTBOOKS, STUDENT development, ELECTRONIC textbooks
Abstract

Copyright of Revista EntreLínguas is the property of Revista EntreLinguas and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2024

4. A gamificação na era da cultura digital: uma proposta didática para o ensino de Língua Inglesa

Author

Motta Gerlach, Alana and Nunes Batista, Bruno

Subjects
Gamificação na educação, Games e educação, Ensino e aprendizagem de línguas, Ensino de Língua Inglesa
Abstract

This work presents an investigation on the influence of games on the daily lives of the digital natives. It is proposed from this research, reflections on the phenomenon of gamification applied to education and its possibilities of insertion in didactic proposals for English Teaching. The intention was to problematize and contextualize this phenomenon from the reality experienced by high school students and, from this contribution, suggest possibilities of gamification application in English language teaching. This contextualization was based on the results of dialogues and issues from a gathering of data, carried out with integrated high school students, which investigated the interest of these students for games, in addition to its possible applicability in the classes. Afterwards the considerations that started from gathering of data, a path was proposed for the construction of gamified didactic proposals, as well as a reflection on the possible combination of gamification with the Task-Based Language Teaching Approach (TBLT - Task Based Learning Teaching) simultaneous with the use of digital technological resources. Beyond the discussions, the intention is to contribute to the construction of innovative English Language teaching proposals, aimed the motivation and engagement of the students that belong to the digital culture age, to a more significant, effective and critical participation in English language classes., Este trabalho apresenta uma investigação sobre influência dos games no cotidiano dos nativos digitais. A partir desta investigação, propõe-se reflexões sobre o fenômeno da gamificação aplicado à educação e suas possibilidades de inserção em propostas didáticas para o ensino de Língua Inglesa. A intenção foi problematizar e contextualizar esse fenômeno a partir da realidade vivenciada por estudantes do ensino médio e, a partir desta contribuição, traçar possibilidades de aplicação da gamificação no ensino de Língua Inglesa. Essa contextualização se deu a partir do resultado de discussões e problematização de uma coleta de dados realizada com alunos do ensino médio integrado, a qual investigou o interesse desses alunos pelos games, além de sua possível aplicabilidade nas aulas. Após as reflexões que partiram da coleta de dados, propôs-se um caminho para a construção de propostas didáticas gamificadas, além de uma reflexão sobre a possível junção da gamificação com a abordagem de ensino de línguas baseada em tarefas (TBLT – Task Based Learning Teaching), concomitante ao uso de recursos tecnológicos digitais. Dadas as reflexões, a intenção é contribuir com a construção de propostas de ensino inovadoras para o ensino de Língua Inglesa, que visem motivar e engajar os alunos que pertencem a era da cultura digital, a uma participação mais significativa, efetiva e crítica em aulas de Língua Inglesa.

Published
2021

5. Evaluating [225Ac]Ac-FAPI-46 for the treatment of soft-tissue sarcoma in mice.

Author

Taddio, Marco F., Doshi, Suraj, Masri, Marwan, Jeanjean, Pauline, Hikmat, Firas, Gerlach, Alana, Nyiranshuti, Lea, Rosser, Ethan W., Schaue, Dorthe, Besserer-Offroy, Elie, Carlucci, Giuseppe, Radu, Caius G., Czernin, Johannes, Lückerath, Katharina, and Mona, Christine E.

Subjects
*CANCER treatment, *IMMUNE checkpoint proteins, *TUMOR growth, *MICE, *PATIENT selection, *IMMUNOGLOBULINS
Abstract

Purpose: Fibroblast Activation Protein (FAP) is an emerging theranostic target that is highly expressed on cancer-associated fibroblasts and on certain tumor cells including sarcoma. We investigated the anti-tumor efficacy of [225Ac]Ac-FAPI-46 as monotherapy or in combination with immune checkpoint blockade (ICB) in immunocompetent murine models of sarcoma sensitive or resistant to ICB.[68Ga]Ga- and [225Ac]Ac-FAPI-46 were tested in subcutaneous FAP+ FSA fibrosarcoma bearing C3H/Sed/Kam mice. The efficacy of up to three cycles of 60 kBq [225Ac]Ac-FAPI-46 was evaluated as monotherapy and in combination with an anti-PD-1 antibody. Efficacy of [225Ac]Ac-FAPI-46 and/or ICB was further compared in FAP-overexpressing FSA (FSA-F) tumors that were sensitive to ICB or rendered ICB-resistant by tumor-induction in the presence of Abatacept.[225Ac]Ac-FAPI-46 was well tolerated up to 3 × 60 kBq but had minimal effect on FSA tumor growth. The combination of three cycles [225Ac]Ac-FAPI-46 and ICB resulted in growth delay in 55% of mice (6/11) and partial tumor regression in 18% (2/11) of mice. In FSA-F tumors with FAP overexpression, both [225Ac]Ac-FAPI-46 and ICB were effective without additional benefits from the combination. In locally immunosuppressed and ICB resistant FAP-F tumors, however, [225Ac]Ac-FAPI-46 restored responsiveness to ICB, resulting in significant tumor regression and tumor-free survival of 56% of mice in the combination group up to 60 days post treatment.[225Ac]Ac-FAPI-46 efficacy is correlated with tumoral FAP expression levels and can restore responsiveness to PD-1 ICB. These data illustrate that careful patient selection based on target expression and rationally designed combination therapies are critically important to maximize the therapeutic impact of FAP-targeting radioligands.Methods: Fibroblast Activation Protein (FAP) is an emerging theranostic target that is highly expressed on cancer-associated fibroblasts and on certain tumor cells including sarcoma. We investigated the anti-tumor efficacy of [225Ac]Ac-FAPI-46 as monotherapy or in combination with immune checkpoint blockade (ICB) in immunocompetent murine models of sarcoma sensitive or resistant to ICB.[68Ga]Ga- and [225Ac]Ac-FAPI-46 were tested in subcutaneous FAP+ FSA fibrosarcoma bearing C3H/Sed/Kam mice. The efficacy of up to three cycles of 60 kBq [225Ac]Ac-FAPI-46 was evaluated as monotherapy and in combination with an anti-PD-1 antibody. Efficacy of [225Ac]Ac-FAPI-46 and/or ICB was further compared in FAP-overexpressing FSA (FSA-F) tumors that were sensitive to ICB or rendered ICB-resistant by tumor-induction in the presence of Abatacept.[225Ac]Ac-FAPI-46 was well tolerated up to 3 × 60 kBq but had minimal effect on FSA tumor growth. The combination of three cycles [225Ac]Ac-FAPI-46 and ICB resulted in growth delay in 55% of mice (6/11) and partial tumor regression in 18% (2/11) of mice. In FSA-F tumors with FAP overexpression, both [225Ac]Ac-FAPI-46 and ICB were effective without additional benefits from the combination. In locally immunosuppressed and ICB resistant FAP-F tumors, however, [225Ac]Ac-FAPI-46 restored responsiveness to ICB, resulting in significant tumor regression and tumor-free survival of 56% of mice in the combination group up to 60 days post treatment.[225Ac]Ac-FAPI-46 efficacy is correlated with tumoral FAP expression levels and can restore responsiveness to PD-1 ICB. These data illustrate that careful patient selection based on target expression and rationally designed combination therapies are critically important to maximize the therapeutic impact of FAP-targeting radioligands.Results: Fibroblast Activation Protein (FAP) is an emerging theranostic target that is highly expressed on cancer-associated fibroblasts and on certain tumor cells including sarcoma. We investigated the anti-tumor efficacy of [225Ac]Ac-FAPI-46 as monotherapy or in combination with immune checkpoint blockade (ICB) in immunocompetent murine models of sarcoma sensitive or resistant to ICB.[68Ga]Ga- and [225Ac]Ac-FAPI-46 were tested in subcutaneous FAP+ FSA fibrosarcoma bearing C3H/Sed/Kam mice. The efficacy of up to three cycles of 60 kBq [225Ac]Ac-FAPI-46 was evaluated as monotherapy and in combination with an anti-PD-1 antibody. Efficacy of [225Ac]Ac-FAPI-46 and/or ICB was further compared in FAP-overexpressing FSA (FSA-F) tumors that were sensitive to ICB or rendered ICB-resistant by tumor-induction in the presence of Abatacept.[225Ac]Ac-FAPI-46 was well tolerated up to 3 × 60 kBq but had minimal effect on FSA tumor growth. The combination of three cycles [225Ac]Ac-FAPI-46 and ICB resulted in growth delay in 55% of mice (6/11) and partial tumor regression in 18% (2/11) of mice. In FSA-F tumors with FAP overexpression, both [225Ac]Ac-FAPI-46 and ICB were effective without additional benefits from the combination. In locally immunosuppressed and ICB resistant FAP-F tumors, however, [225Ac]Ac-FAPI-46 restored responsiveness to ICB, resulting in significant tumor regression and tumor-free survival of 56% of mice in the combination group up to 60 days post treatment.[225Ac]Ac-FAPI-46 efficacy is correlated with tumoral FAP expression levels and can restore responsiveness to PD-1 ICB. These data illustrate that careful patient selection based on target expression and rationally designed combination therapies are critically important to maximize the therapeutic impact of FAP-targeting radioligands.Conclusion: Fibroblast Activation Protein (FAP) is an emerging theranostic target that is highly expressed on cancer-associated fibroblasts and on certain tumor cells including sarcoma. We investigated the anti-tumor efficacy of [225Ac]Ac-FAPI-46 as monotherapy or in combination with immune checkpoint blockade (ICB) in immunocompetent murine models of sarcoma sensitive or resistant to ICB.[68Ga]Ga- and [225Ac]Ac-FAPI-46 were tested in subcutaneous FAP+ FSA fibrosarcoma bearing C3H/Sed/Kam mice. The efficacy of up to three cycles of 60 kBq [225Ac]Ac-FAPI-46 was evaluated as monotherapy and in combination with an anti-PD-1 antibody. Efficacy of [225Ac]Ac-FAPI-46 and/or ICB was further compared in FAP-overexpressing FSA (FSA-F) tumors that were sensitive to ICB or rendered ICB-resistant by tumor-induction in the presence of Abatacept.[225Ac]Ac-FAPI-46 was well tolerated up to 3 × 60 kBq but had minimal effect on FSA tumor growth. The combination of three cycles [225Ac]Ac-FAPI-46 and ICB resulted in growth delay in 55% of mice (6/11) and partial tumor regression in 18% (2/11) of mice. In FSA-F tumors with FAP overexpression, both [225Ac]Ac-FAPI-46 and ICB were effective without additional benefits from the combination. In locally immunosuppressed and ICB resistant FAP-F tumors, however, [225Ac]Ac-FAPI-46 restored responsiveness to ICB, resulting in significant tumor regression and tumor-free survival of 56% of mice in the combination group up to 60 days post treatment.[225Ac]Ac-FAPI-46 efficacy is correlated with tumoral FAP expression levels and can restore responsiveness to PD-1 ICB. These data illustrate that careful patient selection based on target expression and rationally designed combination therapies are critically important to maximize the therapeutic impact of FAP-targeting radioligands. [ABSTRACT FROM AUTHOR]

Published
2024
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