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The aim of this study was to determine the accuracy of the pre-surgical assessment of the mandible using cone beam computed tomography (CBCT) images. For surgical procedures in the mandible, it is important to determine the position of the mandibular canal in order to avoid damage to the inferior alveolar nerve (IAN). The best method to investigate this nerve is with the help of panoramic reconstructed images combined with cross-sectional reconstructed images. To protect the IAN during treatment, this research indicates that a minimal safety zone of 1.13 mm is advisable. When distances were being measured, a larger exaggeration of reality was observed with small distances. It appears that (semi)automatic tracing methods of the mandibular canal still cannot be used in clinical practice. When a CBCT scan reveals a lingual position of the mandibular canal in combination with a narrowing of the mandibular canal at the contact point with the root of a third molar the risk of damaging the IAN increases. CBCT imaging should only be applied in specific cases.

Purpose: The aims of this study were to investigate the effectiveness of cone beam computed tomography (CBCT) compared to panoramic radiography (PR), prior to mandibular third molar removal, in reducing patient morbidity, and to identify risk factors associated with inferior alveolar nerve (IAN) injury., Material and Methods: This multicentre, randomised, controlled trial was performed at three centres in the Netherlands. Adults with an increased risk for IAN injury, as diagnosed from PR, were included in the study. In one arm of the study, patients underwent an additional CBCT prior to third molar surgery. In a second arm of the study, no additional radiographs were acquired. The primary outcome measure was the number of patient-reported altered sensations 1 week after surgery. As secondary outcome measures, the number of patients with objective IAN injury, with long-term (>6 months) IAN injury, the occurrence of other postoperative complications, the Oral Health Related Quality of Life-14 (OHIP-14) questionnaire responses, postoperative pain (visual analogue scale score), duration of surgery, number of emergency visits, and number of missed days of work or study were scored., Results: A total of 268 patients with 320 mandibular third molars were analysed according to the intention-to-treat principle. The overall incidence of IAN injury 1 week after surgery was 6.3%. No significant differences between CBCT and PR for temporary IAN injury (p = 0.64) and all other secondary outcomes were registered. A lingual position of the mandibular canal (MC) and narrowing, in which the diameter of the MC lumen was decreased at the contact area between the MC and the roots, were significant risk factors for temporary IAN injury., Conclusion: Although CBCT is a valuable diagnostic adjunct for identification of an increased risk for IAN injury, the use of CBCT does not translate into a reduction of IAN injury and other postoperative complications, after removal of the complete mandibular third molar. In these selected cases of a high risk for IAN injury, an alternative strategy, such as monitoring or a coronectomy, might be more appropriate. (http://clinicaltrials.gov, NCT02071030)., (Copyright © 2015 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.)

We aimed to investigate the effectiveness of software for automatically tracing the mandibular canal on data from cone-beam computed tomography (CT). After the data had been collected from one dentate and one edentate fresh cadaver head, both a trained Active Shape Model (ASM) and an Active Appearance Model (AAM) were used to automatically segment the canals from the mandibular to the mental foramen. Semiautomatic segmentation was also evaluated by providing the models with manual annotations of the foramina. To find out if the tracings were in accordance with the actual anatomy, we compared the position of the automatic mandibular canal segmentations, as displayed on cross-sectional cone-beam CT views, with histological sections of exactly the same region. The significance of differences between results were analysed with the help of Fisher's exact test and Pearson's correlation coefficient. When tracings based on AAM and ASM were used, differences between cone-beam CT and histological measurements varied up to 3.45mm and 4.44mm, respectively. Manual marking of the mandibular and mental foramina did not improve the results, and there were no significant differences (p=0.097) among the methods. The accuracy of automatic segmentation of the mandibular canal by the AAM and ASM methods is inadequate for use in clinical practice., (Copyright © 2014 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.)

Purpose: To establish the accuracy of cone-beam computed tomographic (CBCT) views in determining the position and diameter of the mandibular canal., Materials and Methods: Two freshly frozen cadaver heads, 1 dentate and 1 edentate, were used to acquire CBCT scans. Measurements on cross-sectional CBCT images were compared with measurements on digitized histologic sections of the same regions in the mandibles. The Student t test was used for statistical analysis., Results: Comparing CBCT with histologic measurements showed that the position of the mandibular canal differed up to 0.47 mm (standard deviation, 0.29 mm). Mandibular canal diameters were up to 22.8% smaller in the CBCT planes. For the dentate jaw, these differences were statistically significant., Conclusion: To be safe, when assessing the mandibular canal position on CBCT views, a 0.76-mm deviation should be taken into account. Because the diameter of the mandibular canal is displayed smaller, an enlargement by 0.74 mm is recommended., (Copyright © 2014 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved.)

Objectives: The purpose of this study was to determine the accuracy of Cone Beam Computerized Tomography (CBCT) reconstructions in displaying bone surface size and cortical layer thickness., Materials and Methods: Two fresh frozen cadaver heads were scanned using a CBCT (i-CAT(™) 3D Imaging System; Imaging Sciences International Inc.). The mandibles were sectioned and digitalized for histological evaluation. Dimensions as measured on these sections were compared with CBCT measurements of the same region with the use of 3D image-based planning software (Procera System NobelGuide(™); Nobel Biocare). To allow optimal comparison between histological and CBCT sections, reference markers were placed into the mandibles. The Student t-test was utilized to analyze the data. Differences with P-values <0.05 were considered significant., Results: The total height and width of the mandibular body, as measured on CBCT views, were larger compared with the histological values with a maximum difference of 0.33 mm (SD ± 0.34). Cortical thickness measurements were significantly thicker on CBCT sections (P < 0.006) with absolute differences ranging up to ±0.63 mm (SD ±0.28) and relative differences ranging up to 82.6%., Conclusion: CBCT images (i-CAT 3D Imaging System), viewed on the planning software Procera System NobelGuide, tend to overestimate the anatomical truth in assessing both bone height and width; especially cortical thicknesses are depicted thicker than in reality. When using CBCT images for presurgical assessment, one should be aware of this phenomenon of exaggeration of dimensions., (© 2012 John Wiley & Sons A/S.)

Purpose: To investigate the reproducibility of 3 different tracing methods to determine a reliable method to define the proper anatomical position of the mandibular canal based on cone beam computed tomography (CBCT) data., Materials and Methods: Five dentate and 5 edentate patients were selected at random from the CBCT database. Two independent observers traced both the left and the right mandibular canal using 3-dimensional image-based planning software (Procera System NobelGuide; Nobel Biocare, Göteborg, Sweden). All mandibular canals were traced using 3 different methods. Method I was based on coronal views, also known as cross-sections. Panorama-like reconstructions were the starting point for method II. The third method combined methods I and II., Results: With respect to interobserver reliability, no significant difference (P = .34) for the various methods was observed. The reproducibility was better in edentate than in dentate jaws (P = .0015). The difference between 2 tracings was the lowest for the combined method: within a range of 1.3 mm in 95% of the course of the canal. The most obvious deviations were mainly seen in the anterior part of the canal., Conclusions: The best reproducible method for mandibular canal tracing is the combined method III. Between observers, still a mean 95th percentile deviation threshold of 1.3 mm (SD 0.384) is noted, indicating that a safety zone of 1.7 mm should be respected. When planning surgery on CBCT-based data, surgeons should be aware of the obvious deviations located in the region of the anterior loop of the canal., (2010 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved.)

Introduction: Orbital cellulitis is an uncommon, potentially devastating condition that, when not promptly and adequately treated, can lead to serious sequelae. The presenting clinical signs are proptosis, swelling, ophthalmoplegia, pain and redness of the peri-orbital tissues. A number of cases have been reported in which these symptoms have been mistakenly interpreted as being secondary to an orbital infection whilst, in fact, other pathology was present., Discussion: We add another case in which, on clinical grounds and after radiological assessment and laboratory tests, a working diagnosis of orbital cellulitis of the left eye was made. It was only after histopathological analysis of a soft tissue specimen from the maxillary sinus that a diagnosis of an AIDS-related plasmablastic lymphoma was made. The patient was referred to the department of haematology where chemotherapeutic treatment for the lymphoma and the HIV infection was started. This case report adds another differential diagnosis of orbital cellulitis to the existing literature.

Radiotherapy is used in the setting of curative treatment for head and neck cancer. Xerostomia and related problems occur when major salivary glands are included in the irradiation fields. This reduces quality of life (QOL). Hyperbaric oxygen therapy (HBOT) is a well accepted treatment or prevention modality for osteoradionecrosis of the jawbones and soft-tissue necrosis. It is unknown if and to what extent HBOT influences xerostomia and xerostomia-related QOL. To address this, a prospective study was conducted. Twenty-one patients who underwent radiotherapy for an oral or oropharyngeal carcinoma completed a European Organization for Research and Treatment of Cancer QOL questionnaire before HBOT, as part of the treatment/prevention of osteoradionecrosis, and 1 and 2 years after HBOT. Swallowing-related problems significantly decreased in time, and there was a reported subjective increase in saliva quantity and an improvement in sense of taste. The results suggest that HBOT may positively influence these long-term radiotherapy sequelae.