Search

Your search keyword '"Geroldi, D."' showing total 213 results
Start Over Author "Geroldi, D."
213 results on '"Geroldi, D."'

17. Neuro Endocrinol Lett: An open-label trial of L-5-hydroxytryptophan in subjects with romantic stress

Author

Emanuele, E., Bertona, M., Minoretti, P., and Geroldi, D.

Subjects
Tryptophan -- Physiological aspects -- Research -- Health aspects, Serotonin -- Health aspects -- Research -- Physiological aspects, Stress (Psychology) -- Care and treatment -- Drug therapy -- Research, Health
Abstract

This open-label trial assessed the clinical efficacy of L-5-hydroxytryptophan (5-HTP), a natural serotonin precursor, in nondepressed young subjects with high levels of romantic stress. Since both neurotrophins and serotonin have [...]

Published
2011

27. The M694V variant of the familial mediterranean fever gene ss associated with sporadic early-onset Alzheimer's disease in an Italian population sample.

Author

Arra M, Emanuele E, Martinelli V, Minoretti P, Bertona M, and Geroldi D

Abstract

Background: Inflammation is deemed to play a crucial role in the pathogenesis of Alzheimer's disease (AD). We sought to determine whether the proinflammatory M694V mutation of pyrin, the gene responsible for familial Mediterranean fever, could lead to an increased risk for AD. Methods: We compared the M694V variant genotypes in 378 sporadic AD patients and 384 healthy control subjects of Italian descent. Results: After adjustment for potential confounders, the M694V mutation was found to be associated with an increased risk for AD in subjects with an age at onset of 65 years or younger (multivariate-adjusted odds ratio, OR: 3.01, 95% confidence interval, CI: 1.24-6.72, p = 0.021), but not in patients with an age at onset older than 65 years (multivariate-adjusted OR: 0.81, 95% CI: 0.34-1.99, p = 0.847). Kaplan-Meier analysis indicated that AD patients bearing the M694V mutation presented with disease onset 7 years earlier than carriers of the wild-type genotype (log rank = 41.61, p < 0.001). Conclusion: Our data indicate that the M694V sequence variant in the pyrin gene might influence the age at onset of AD in the Italian population. Copyright © 2007 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]

Published
2006

39. Enhanced antithrombotic mechanisms in patients with maturity-onset diabetes mellitus without thromboembolic complications

Author

Edoardo Ascari, Ettore Ferrari, Guido Grignani, Gabriella Gamba, Geroldi D, Solerte B, and Pacchiarini L

Subjects
Male, medicine.medical_specialty, Antifibrinolytic, medicine.drug_class, Antithrombin III, Gastroenterology, Veins, Hba1c level, Plasminogen Activators, Diabetes mellitus, Internal medicine, Antithrombotic, von Willebrand Factor, medicine, Diabetes Mellitus, Humans, In patient, Antigens, Aged, Factor VIII, business.industry, Fibrinolysis, Biological activity, Hemoglobin A, Hematology, Disseminated Intravascular Coagulation, Middle Aged, medicine.disease, Constriction, Basal (medicine), Female, Maturity-Onset Diabetes, business
Abstract

SummarySome haemostatic parameters have been evaluated in a group of rigorously selected patients with maturity-onset diabetes mellitus without thromboembolic complications and in apparently normal subjects of the same age before and after the venous occlusion test (VOT).In basal conditions diabetics had higher levels of AT III as biological activity and higher fibrinolytic and antifibrinolytic activities than controlsAfter VOT, F VIII R:Ag increased significantly in both groups, more markedly in controls than in diabetics, while F VIII: C showed no modification.Also AT III R:Ag increased after the test, but such variation was significant only in diabetics; on the contrary, the biological activity of AT III was always significantly decreased after the test.After VOT there were also in both groups highly significant increases in the fibrinolytic and antifibrinolytic activities.Finally, HbA1c levels directly correlated with AT III as biological activity before VOT, but with no other parameter either before or after the test.These data suggest the existence in patients with diabetes mellitus without thromboembolic complications of an activated protective mechanism against intravascular clotting.

Published
1981

44. LAV antibodies and IgG subclasses in haemophilia

Author

Geroldi D, G Ippoliti, Edoardo Ascari, Gabriella Gamba, Maria Antonietta Avanzini, and A Plebani

Subjects
LAV antibodies, LAV Antibodies, business.industry, Immunology, medicine, haemophilia, Hematology, Igg subclasses, IgG subclasses, Haemophilia, medicine.disease, business

Catalog

Books, media, physical & digital resources
See catalog results