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1. [Expression of cytoskeleton genes in culture of human mesenchymal stromal cells in different periods of simulating the effects of microgravity].

Author

Gershkovich PM, Gershkovich IuG, and Buravkova LB

Subjects
Adaptation, Physiological, Bone Marrow Cells metabolism, Cells, Cultured, Humans, Stromal Cells metabolism, Cytoskeletal Proteins genetics, Cytoskeleton metabolism, Gene Expression Regulation, Mesenchymal Stem Cells metabolism, Weightlessness Simulation adverse effects
Abstract

Simulation of microgravity for cultivated multipotent mesenchymal stromal cells (MSCs) from human marrow changes transiently expression of genes associated with actin cytoskeleton; the effect fades away partially in 120 hrs. following microgravity and completely after 24-hr cell readaptation to static conditions. These changes in expression of some cytoskeleton genes seem to predetermine their reaction to simulated microgravity, and therefore inhibition of MSCs differentiation potential.

Published
2011

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