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8 results on '"Geuns, R.J. van"'

1. Serial Assessment of Tissue Precursors and Progression of Coronary Calcification Analyzed by Fusion of IVUS and OCT 5-Year Follow-Up of Scaffolded and Nonscaffolded Arteries

Author

Zeng, Y.P., Tateishi, H., Cavalcante, R., Tenekecioglu, E., Suwannasom, P., Sotomi, Y., Collet, C., Nie, S.P., Jonker, H., Dijkstra, J., Radu, M.D., Raber, L., McClean, D.R., Geuns, R.J. van, Christiansen, E.H., Fahrni, T., Koolen, J., Onuma, Y., Bruining, N., Serruys, P.W., Cardiology, Graduate School, ACS - Amsterdam Cardiovascular Sciences, ACS - Heart failure & arrhythmias, and Surgery

Subjects
calcification, fusion, Vascular damage Radboud Institute for Health Sciences [Radboudumc 16], Journal Article, bioresorbable vascular scaffold
Abstract

OBJECTIVES The aim of this study was to assess calcium growth with fused grayscale intravascular ultrasound (IVUS), IVUS-virtual histology, and optical coherence tomography (OCT) from baseline to 5-year follow-up in patients treated with bioresorbable vascular scaffolds. BACKGROUND IVUS and OCT have individual strengths in assessing plaque composition and volume. Fusion of images obtained using these methods could potentially aid in coronary plaque assessment. METHODS Anatomic landmarks and endoluminal radiopaque markers were used to fuse OCT and IVUS images and match baseline and follow-up. RESULTS Seventy-two IVUS-virtual histology and OCT paired matched cross-sectional in-and out-scaffold segments were fused at baseline and follow-up. In total, 46 calcified plaques at follow-up were detected using the fusion method (33 in-scaffold, 13 out-scaffold), showing either calcium progression (52.2%) or de novo calcifications (47.8%). On OCT, calcification volume increased from baseline to follow-up by 2.3 +/- 2.4 mm(3) (p = 0.001). The baseline virtual histologic tissue precursors of dense calcium at follow-up were necrotic core in 73.9% and fibrous or fibrofatty plaque in 10.9%. In 15.2%, calcium was already present at baseline. Precursors on OCT were lipid pool in 71.2%, fibrous plaque in 4.3%, and fibrocalcific plaque in 23.9%. CONCLUSIONS The use of OCT and IVUS fusion imaging shows similar calcium growth in-and out-scaffold segments. Necrotic core is the most frequent precursor of calcification. The scaffold resorption process creates a tissue layer that re-caps the calcified plaques. (Absorb Clinical Investigation, Cohort B [ABSORB B]; NCT00856856) (C) 2017 by the American College of Cardiology Foundation

Published
2017
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6. Temporal Evolution of Strut Light Intensity After Implantation of Bioresorbable Polymeric Intracoronary Scaffolds in the ABSORB Cohort B Trial - An Application of a New Quantitative Method Based on Optical Coherence Tomography

Author

Nakatani, S., Onuma, Y., Ishibashi, Y., Eggermont, J., Zhang, Y.J., Campos, C.M., Cho, Y.K., Liu, S.N., Dijkstra, J., Reiber, J.H.C., Perkins, L., Sheehy, A., Veldhof, S., Rapoza, R., Es, G.A. van, Garcia-Garcia, H.M., Geuns, R.J. van, Serruys, P.W., and ABSORB Cohort B Investigators

Subjects
Light intensity analysis, Bioresorbable vascular scaffold, Optical coherence tomography, Bioresorption, Coronary artery disease
Published
2014

7. Ascending aortic diameters in congenital aortic stenosis: cardiac magnetic resonance versus transthoracic echocardiography

Author

Linde, D. van der, Rossi, A. de, Yap, S.C., McGhie, J.S., Bosch, A.E. van den, Kirschbaum, S.W., Russo, B., Dijk, A.P.J. van, Moelker, A., Krestin, G.P., Geuns, R.J. van, Roos-Hesselink, J.W., Linde, D. van der, Rossi, A. de, Yap, S.C., McGhie, J.S., Bosch, A.E. van den, Kirschbaum, S.W., Russo, B., Dijk, A.P.J. van, Moelker, A., Krestin, G.P., Geuns, R.J. van, and Roos-Hesselink, J.W.

Abstract

Item does not contain fulltext, OBJECTIVES/BACKGROUND: Congenital aortic stenosis (AS) is the most common obstructive left heart lesion in the young adult population and often complicated by aortic dilatation. Our objective was to evaluate accuracy of aortic imaging with transthoracic echocardiography (TTE) compared with cardiac magnetic resonance (CMR). METHODS: Aortic diameters were measured at 4 levels by CMR and TTE. Agreement and concordance were assessed by Pearson's correlation and Bland-Altman analysis. RESULTS: Fifty-nine patients (age 33 +/- 8 years; 66% male) with congenital AS and a bicuspid aortic valve (BAV) were included. Aortic diameters were generally smaller with TTE than with CMR. The best correlation was found at the level of the sinotubular junction (R(2) = 0.78) with a bias of 1.46 mm (limits of agreement: -5.47 to +8.39 mm). In patients with an aortic aneurysm >40 mm (n = 29) the correlation and agreement between TTE and CMR were found to be less good when compared with patients with normal aortic diameters, especially at the level of the proximal ascending aorta. The correlation and agreement between both imaging modalities were better in patients with type 1 BAV compared with type 2 BAV. Intra- and interobserver variability was smaller with CMR (1.8-5.9%) compared with TTE (6.9-15.0%). CONCLUSIONS: CMR was found to be superior to TTE for imaging of the aorta in patients with congenital AS, especially at the level of the proximal ascending aorta when an aortic aneurysm is present. Therefore, ideally CMR should be performed at least once to ensure an ascending aortic aneurysm is not missed.

Published
2013

8. In vivo assessment of three dimensional coronary anatomy using electron beam computed tomography after intravenous contrast administration

Author

Rensing, B.J., Geuns, R.J. van, Ooijen, P.M.A. van, Feyter, P.J. de, Bongaerts, A.H.H., and Oudkerk, M.

Abstract

Intravenous coronary angiography with electron beam computed tomography (EBCT) allows for the non-invasive visualisation of coronary arteries. With dedicated computer hardware and software, three dimensional renderings of the coronary arteries can be constructed, starting from the individual transaxial tomograms. This article describes image acquisition, postprocessing techniques, and the results of clinical studies. EBCT coronary angiography is a promising coronary artery imaging technique. Currently it is a reasonably robust technique for the visualisation and assessment of the left main and left anterior descending coronary artery. The right and circumflex coronary arteries can be visualised less consistently. Improvements in image acquisition and postprocessing techniques are expected to improve visualisation and diagnostic accuracy of the technique.

Published
1999

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